title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Tracking multiple particles in fluorescence time-lapse microscopy images via probabilistic data association. | Tracking subcellular structures as well as viral structures displayed as 'particles' in fluorescence microscopy images yields quantitative information on the underlying dynamical processes. We have developed an approach for tracking multiple fluorescent particles based on probabilistic data association. The approach co... | 25,252,280 | [
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[The evolution of human Y chromosome]. | The human Y chromosome is always intriguing for researchers, because of its role in gender determination and its unusual evolutionary history. The Y chromosome evolves from an autosome, and its evolution has been characterized by massive gene decay. The lack of recombination and protein-coding genes and high content of... | 25,252,301 | [
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[Gene mining of sulfur-containing amino acid metabolic enzymes in soybean]. | The genes of sulfur-containing amino acid synthetases in soybean are essential for the synthesis of sulfur-containing amino acids. Gene mining of these enzymes is the basis for the molecular assistant breeding of high sulfur-containing amino acids in soybean. In this study, using software BioMercator2.1, 113 genes of s... | 25,252,311 | [
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[The practice and discussion of the physical knowledge stepping into genetics teaching]. | Genetics, one of the core courses of biological field, play a key role in biology teaching and research. In fact, there exists high similarity between many genetic knowledge and physical knowledge. Due to strong abstract of genetic contents and the weak basis of genetics, some students lack of interests to study geneti... | 25,252,313 | [
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Chlorine inactivation of hepatitis E virus and human adenovirus 2 in water. | Hepatitis E virus (HEV) is transmitted via the fecal-oral route and has been recognized as a common source of large waterborne outbreaks involving contaminated water in developing countries. Thus, there is the need to produce experimental data on the disinfection kinetics of HEV by chlorine in water samples with divers... | 25,252,347 | [
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[Experience of application of nonsuture electrowelding technologies in thoracic surgery]. | Experience of application of nonsuture electrowelding technologies (NEWT) was analyzed while performing open and miniinvasive thoracoscopic operations in 116 patients. No essential differences were revealed while comparing domestic and foreign electrowelding surgical instruments. Possibility of wide application of NEWT... | 25,252,414 | [
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Avoiding narcotic analgesics in young children. | Recent warnings regarding the use of codeine in young children have triggered changes in postoperative pain management with a trend toward over the counter pain medicines. A summary of the recent FDA warnings and current pain protocols is contained within. | 25,252,426 | [
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Relationship between tooth dimensions and malocclusion. | To observe the difference in dimension of teeth among adult females with and without malocclusion. The cross-sectional study was conducted at Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi, from April 2011 to April 2013, and used non-probability consecutive samplin... | 25,252,487 | [
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Pumpkin seed oil (prostafit) or prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia. | To assess the efficacy of drugs containing herbal extracts in the treatment of Benign Prostatic Hyperplasia. The clinical trial study was performed in 2011-2012 at Imam Reza Hospital, Mashhad, Iran. One hundred patients with Benign Prostatic Hyperplasia were randomly divided into 2 equal groups receiving prostafit and ... | 25,252,490 | [
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Two cases of Creutzfeldt-Jakob disease from an ongoing dementia registry in Pakistan. | Creutzfeldt-Jakob disease (CJD) is a rare prion disease that leads to a rapidly progressive dementia (RPD) and associated neurological features. It is not well documented in our country; therefore its true prevalence in Pakistan is not known. Here we report two cases of sporadic probable CJD seen in our hospital. The f... | 25,252,497 | [
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Awareness among general population attending Civil Hospital Karachi about risk factors associated with infertility. | To evaluate awareness amongst general population attending Civil Hospital Karachi regarding risk factors associated with infertility. A descriptive study was conducted on subjects who were attendants to the patients admitted in Civil Hospital Karachi or had appointment in outpatient department. They were interviewed on... | 25,252,505 | [
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Effectiveness of behavioural management on migraine in adult patients visiting family practice clinics: a randomized controlled trial. | To assess the effectiveness of behavioural management in the treatment of migraine among adult patients. The randomised control trial was conducted from August 2011 to August 2012 at the Aga Khan University Hospital, Karachi, in which adult patients aged 18-65 years were recruited with diagnosis of migraine from five o... | 25,252,515 | [
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Recurrent meningitis in a child with IgG3 subclass deficiency. | Recurrent meningitis is an uncommon life-threatening condition. Here, the case of a 6-year-old boy is reported who had two episodes of meningitis with an IgG3 subclass deficiency. The boy had aseptic meningitis at the age of 3 years, followed by bacterial meningitis at the age of 4 years. Primary immunoglobulin deficie... | 25,252,530 | [
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Thyroid disorders and diabetes. | Thyroid disorders and diabetes mellitus are two of the most common endocrine conditions, which occur with greater frequency along with each other. This communication describes current knowledge about these twin diseases. Epidemiology, clinical features, laboratory abnormalities, screening and therapeutic implication of... | 25,252,531 | [
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[The choice of pancreaticojejunal anastomosis based on the performance experience of 200 operations of pancreaticoduodenal resection]. | Analysis of the surgical treatment results in 200 patients, operated for obstructive diseases of the biliopancreatoduodenal zone, in whom pancreaticoduodenal resection (PDR) was performed in 1991 - 2013 yrs period, were presented. The choice of the pancreaticojejunoanastomosis (PJA) variant in PDR have depended on dime... | 25,252,541 | [
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[Preoperative portal vein embolization: dynamics of portal pressure]. | The pressure dynamics was studied in a portal vein (PV) in patients, suffering focal hepatic pathology, to whom portal vein embolization (PVE) was performed as a stage of preparation to radical hepatic resection. In 236 patients the immediate measurement of pressure in a PV was performed intraoperatively before and aft... | 25,252,551 | [
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[Improvement of approach to performance of lumbar sympathetic blockade in patients with tissue ischemia of the lower extremities]. | New access for performance of sympathic blockade in region of aortal bifurcation, was elaborated, basing on calculations, conducted on 30 spiral computeric tomograms of lumbar and sacral parts of vertebral column. Application of the method permits to escape such complications, as a renal and the main vessels damage, th... | 25,252,554 | [
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[Peculiarities of clinical course and factors impacting the results of surgical treatment of intracerebral hematoma in isolated cranio-cerebral trauma]. | Peculiarities of clinical course of intracerebral hematoma (ICH) in isolated cranio-cerebral trauma (CCT), and factors, influencing the surgical treatment results, were analyzed. Medical histories of 188 injured persons, suffering isolated CCT, were analyzed, in 14 of them ICH was revealed. In isolated CCT the brain co... | 25,252,556 | [
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[Feasibility study of septoplasties and septorhinoplasties in ambulatory surgery]. | Feasibility assessment of septoplasty and septorhinoplasty as ambulatory procedures, from analysis of the activity of a university ENT department. This is a retrospective analysis over 2 years. The demographic data, the distance between the patient's home and the ENT department, the cause of the septal deviation, the e... | 25,252,573 | [
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[Karapandzic flap for reconstruction of extensive defects of the lower lip]. | To discuss advantages and disadvantages of Karapandzic flap for reconstruction of extensive defects of the lower lip. Two clinical observations and a review of the literature are presented. The Karapandzic flap requires only one operating time. The tissue used to reconstruct the lower lip is very close to the resected ... | 25,252,574 | [
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[Nasal tumours of the threshold and vestibule]. | The nasal vestibule tumors are not very frequent. The pronostic can be severe if the first treatment is not effective. The authors present a personnal nine pateints' serie. They point out the clinical aspect, the evolutivity of these tumors and more specially the local extension which can produce recurrencies. The diff... | 25,252,578 | [
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Comparing the risk of developing uveitis in patients initiating anti-tumor necrosis factor therapy for ankylosing spondylitis: an analysis of a large US claims database. | To compare the risk of developing uveitis in patients initiating anti-tumor necrosis factor (anti-TNF) agents (adalimumab, etanercept, and infliximab) for ankylosing spondylitis (AS). Anti-TNF-naive patients with a diagnosis of AS and without a history of uveitis (N = 2115) who subsequently initiated anti-TNF therapy f... | 25,252,590 | [
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A thiazole coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems. | Sequence-specific recognition of DNA by small turn-on fluorescence probes is a promising tool for bioimaging, bioanalytical and biomedical applications. Here, the authors report a novel cell-permeable and red fluorescent hemicyanine-based thiazole coumarin (TC) probe for DNA recognition, nuclear staining and cell cycle... | 25,252,596 | [
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[Ultrasound diagnostics in ophthalmology (standardized echography): part 1: principles and diseases of the eyeball]. | Ultrasound diagnostics has been one of the most important additional diagnostic non-invasive techniques in ophthalmology for many decades and is essential for many intraocular and orbital diseases. When echographic investigations and analysis of the echograms obtained are correctly carried out, ultrasound diagnostics d... | 25,252,599 | [
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The REFLO-STEMI trial comparing intracoronary adenosine, sodium nitroprusside and standard therapy for the attenuation of infarct size and microvascular obstruction during primary percutaneous coronary intervention: study protocol for a randomised controlled trial. | Microvascular obstruction (MVO) secondary to ischaemic-reperfusion injury is an important but underappreciated determinant of short- and longer-term outcome following percutaneous coronary intervention (PCI) treatment of ST-elevation myocardial infarction (STEMI). Several small studies have demonstrated a reduction in ... | 25,252,600 | [
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Improved survival in HPV/p16-positive oropharyngeal cancer patients treated with postoperative radiotherapy. | In the literature, HPV infection and/or p16 positivity have been consistently demonstrated to correlate with improved response rates in oropharyngeal squamous cell carcinoma (OPSCC) patients treated with primary radiotherapy (RT) alone and in combination with chemotherapy. However, the exact role of HPV/p16 positivity ... | 25,252,603 | [
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Associations of macular thickness in spectral-domain OCT with ocular and systemic cardiovascular parameters - the MIPH Eye & Health Study. | Beyond in-vivo histological analysis of retinal tissue, optical coherence tomography (OCT) allows quantitative image analysis. This study evaluates associations of macular retinal thickness measured with spectral-domain OCT (SD-OCT) and ocular and systemic cardiovascular parameters in adult subjects. An epidemiological... | 25,252,606 | [
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Crystal structure of class III chitinase from pomegranate provides the insight into its metal storage capacity. | Chitinase hydrolyzes the β-1,4-glycosidic bond in chitin. In higher plants, this enzyme has been regarded as a pathogenesis-related protein. Recently, we identified a class III chitinase, which functions as a calcium storage protein in pomegranate (Punica granatum) seed (PSC, pomegranate seed chitinase). Here, we solve... | 25,252,615 | [
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Evaluation of pre-induction temperature, cell growth at induction and IPTG concentration on the expression of a leptospiral protein in E. coli using shaking flasks and microbioreactor. | Leptospirosis is a zoonose that is increasingly endemic in built-up areas, especially where there are communities living in precarious housing with poor or non-existent sanitation infrastructure. Leptospirosis can kill, for its symptoms are easily confused with those of other diseases. As such, a rapid diagnosis is req... | 25,252,618 | [
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Adrenal oncocytic phaeochromocytoma with putative adverse histologic features: a unique case report and review of the literature. | Oncocytic phaeochromocytomas are exceedingly rare tumours. To date, there are three reported cases in the literature. This report describes a case of adrenal oncocytic phaeochromocytoma with unique features and malignant potential in a 68-year-old man. The patient presented with an incidental non-functional mass discov... | 25,252,620 | [
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Therapeutic biomarkers in lung neuroendocrine neoplasia. | The well-known classification of neuroendocrine neoplasms of the lung into four major subtypes (including typical and atypical carcinoids and small- and large-cell neuroendocrine carcinomas) has a proven prognostic validity but only partially helps to predict the response to specific therapies. Therapeutic biomarkers a... | 25,252,622 | [
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Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle. | Cancer cells are characterized by a deregulated cell cycle that facilitates abnormal proliferation by allowing cells to by-pass tightly regulated molecular checkpoints such as the G1/S restriction point. To facilitate early diagnosis and the identification of new drug targets, current research efforts focus on studies ... | 25,252,636 | [
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The effects of breast milk storage and freezing procedure on interleukine-10 levels and total antioxidant activity. | To compare interleukine-10 (IL-10) and total antioxidant capacity (TAC) levels after breast milk storage by studying premature and term mothers’ colostrum and mature milk and by analyzing those levels relative to gestational week. Fifty-four colostrum and mature breast milk samples were collected from both premature an... | 25,252,637 | [
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The immune response against Chlamydia suis genital tract infection partially protects against re-infection. | The aim of the present study was to reveal the characteristic features of genital Chlamydia suis infection and re-infection in female pigs by studying the immune response, pathological changes, replication of chlamydial bacteria in the genital tract and excretion of viable bacteria. Pigs were intravaginally infected an... | 25,252,649 | [
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[Autism in the first year]. | At present autism can be diagnosed with a high degree of reliability between the ages of 18 months and 2 years. Yet, the first symptoms are already present long before the diagnosis is made. This has led to a number of retrospective and prospective studies being conducted with the aim of detecting manifestations that a... | 25,252,657 | [
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[Epilepsy and cognition: the role of antiepileptic drugs]. | Multiple factors underlie the cognitive changes associated with epilepsy, including the effect of antiepileptic drug (AED) therapy itself. The use of AEDs in the management of epilepsy requires an ongoing risk-benefit analysis that attempts to maximize seizure control while minimizing adverse cognitive side-effects. Th... | 25,252,666 | [
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p53 as a retrovirus-induced oxidative stress modulator. | Infection of astrocytes by the neuropathogenic mutant of Moloney murine leukemia virus, ts1, exhibits increased levels of reactive oxygen species (ROS) and signs of oxidative stress compared with uninfected astrocytes. Previously, we have demonstrated that ts1 infection caused two separate events of ROS upregulation. T... | 25,252,686 | [
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PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. | BRCA1 promotes homologous recombination-mediated DNA repair (HRR). However, HRR must be tightly regulated to prevent illegitimate recombination. We previously found that BRCA1 HRR function is regulated by the RAP80 complex, but the mechanism was unclear. We have now observed that PARP1 interacts with and poly-ADP-ribos... | 25,252,691 | [
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Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. | NRAS mutation at codons 12, 13, or 61 is associated with transformation; yet, in melanoma, such alterations are nearly exclusive to codon 61. Here, we compared the melanoma susceptibility of an NrasQ61R knock-in allele to similarly designed KrasG12D and NrasG12D alleles. With concomitant p16INK4a inactivation, KrasG12D... | 25,252,692 | [
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Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial. | Remote ischaemic preconditioning (RIPC), using brief cycles of limb ischaemia/reperfusion, is a non-invasive, low-cost intervention that may reduce perioperative myocardial injury (PMI) in patients undergoing cardiac surgery. We investigated whether RIPC can also improve short-term clinical outcomes. One hundred and ei... | 25,252,696 | [
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Disrupted reproduction, estrous cycle, and circadian rhythms in female mice deficient in vasoactive intestinal peptide. | The female reproductive cycle is gated by the circadian timing system and may be vulnerable to disruptions in the circadian system. Prior work suggests that vasoactive intestinal peptide (VIP)-expressing neurons in the suprachiasmatic nucleus (SCN) are one pathway by which the circadian clock can influence the estrous ... | 25,252,712 | [
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An ethnobotanical study of the less known wild edible figs (genus Ficus) native to Xishuangbanna, Southwest China. | The genus Ficus, collectively known as figs, is a key component of tropical forests and is well known for its ethnobotanical importance. In recent decades an increasing number of studies have shown the indigenous knowledge about wild edible Ficus species and their culinary or medicinal value. However, rather little is ... | 25,252,723 | [
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Procedure-dependent construction of two isomers of trimeric self-assembled boronic esters. | A procedure-dependent selective construction of two isomers of trimeric boronic esters was realized. A capsule-like trimeric boronic ester was constructed by the direct connection of two kinds of self-assembled boronic esters via [3+2] cycloaddition, while the tricyclic trimeric boronic ester was obtained by the self-a... | 25,252,724 | [
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[Predictive factors of anxiety disorders]. | Anxiety disorders are among the most frequent mental disorders in Europe (12-month prevalence 14%) and impose a high socioeconomic burden. The pathogenesis of anxiety disorders is complex with an interaction of biological, environmental and psychosocial factors contributing to the overall disease risk (diathesis-stress... | 25,252,735 | [
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[Prognostic and predictively relevant factors for multiple sclerosis]. | The immunotherapy of multiple sclerosis (MS) is currently one of the most dynamic fields in clinical neurology. The comprehensive number of well-established and new innovative treatment options are a challenge for an intensive preoccupation with the differential indications and an activity-driven treatment control. In ... | 25,252,736 | [
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A systematic review of Hepatitis C virus treatment uptake among people who inject drugs in the European Region. | Fifteen million adults in the World Health Organization European Region are estimated to have active hepatitis C infection. Intravenous drug use is a major hepatitis C transmission route in this region, and people who inject drugs (PWID) constitute a high-risk and high-prevalence population. A systematic review was con... | 25,252,742 | [
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High sensitivity cardiac troponin assays in the clinical laboratories. | Immunoassays measuring cardiac troponins I or T have become firmly established as critical tools for diagnosing acute myocardial infarction. While most contemporary assays provide adequate diagnostic performance, the increased sensitivity and precision of the new, high sensitivity assays that have already been introduc... | 25,252,753 | [
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The effect of a mandibular advancement appliance on cervical lordosis in patients with TMD and cervical pain. | A preliminary study to compare cervical lordosis by means of cervical cephalometric analysis, before and after six months of continuous mandibular advancement appliance (MAA) use, and to show how physical therapy posture re-education would improve the cervical lordosis angle. Twenty-two female patients with temporomand... | 25,252,766 | [
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0.4104652,
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0.007171232,
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Factors associated with unhealthy behaviours and health outcomes: a cross-sectional study among Tuscan adolescents (Italy). | We aimed to determine the extent to which three core variables (school environment, peer group and family affluence) were associated with unhealthy behaviours and health outcomes among Tuscan adolescents. The unhealthy behaviours considered were smoking, alcohol consumption, sedentary lifestyle and irregular breakfast ... | 25,252,790 | [
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0.2343779,
0.4723568,
0.1327779,
0.0034... |
Pheromone receptor evolution in the cryptic leafroller species, Ctenopseustis obliquana and C. herana. | How new mate recognition systems evolve when changes are required in both the male and female components remains a conundrum. Here, we investigated the molecular basis of pheromone reception in two species of tortricid (leafroller) moth, Ctenopseustis obliquana and C. herana. Male C. obliquana are attracted to a 90:10 ... | 25,252,791 | [
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0.213... |
PuFFIN--a parameter-free method to build nucleosome maps from paired-end reads. | We introduce a novel method, called PuFFIN, that takes advantage of paired-end short reads to build genome-wide nucleosome maps with larger numbers of detected nucleosomes and higher accuracy than existing tools. In contrast to other approaches that require users to optimize several parameters according to their data (... | 25,252,810 | [
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Global perspectives in hospitalized heart failure: regional and ethnic variation in patient characteristics, management, and outcomes. | Heart failure (HF) is a public health problem of global proportions afflicting more than 25 million patients worldwide. Despite stable or declining per capita hospitalization rates in the USA and several European countries, there are over one million hospitalizations for HF annually in the USA, with similar numbers in ... | 25,252,827 | [
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Identifying biochemical phenotypic differences between cryptic species. | Molecular genetic methods can distinguish divergent evolutionary lineages in what previously appeared to be single species, but it is not always clear what functional differences exist between such cryptic species. We used a metabolomic approach to profile biochemical phenotype (metabotype) differences between two puta... | 25,252,836 | [
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Experimental reduction in dietary omega-3 polyunsaturated fatty acids depresses sperm competitiveness. | The health benefits of diets containing rich sources of long-chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFA) are well documented and include reductions in the risk of several diseases typical of Western societies. The dietary intake of n-3 LC-PUFA has also been linked to fertility, and there is abundant evidenc... | 25,252,837 | [
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A knowledge translation tool improved osteoporosis disease management in primary care: an interrupted time series analysis. | Osteoporosis affects over 200 million people worldwide at a high cost to healthcare systems, yet gaps in management still exist. In response, we developed a multi-component osteoporosis knowledge translation (Op-KT) tool involving a patient-initiated risk assessment questionnaire (RAQ), which generates individualized b... | 25,252,858 | [
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ARYANA: Aligning Reads by Yet Another Approach. | Although there are many different algorithms and software tools for aligning sequencing reads, fast gapped sequence search is far from solved. Strong interest in fast alignment is best reflected in the $10(6) prize for the Innocentive competition on aligning a collection of reads to a given database of reference genome... | 25,252,881 | [
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Stress induced acquisition of somatic embryogenesis in common bean Phaseolus vulgaris L. | Common bean Phaseolus vulgaris L. has been shown to be a recalcitrant plant to induce somatic embryogenesis (SE) under in vitro conditions. We used an alternative strategy to induce SE in common bean based upon the use of a cytokinin (BAP) coupled with osmotic stress adaptation instead of SE response that is induced by... | 25,252,886 | [
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Characterization of the 'Xiangshui' lemon transcriptome by de novo assembly to discover genes associated with self-incompatibility. | Seedlessness is a desirable character in lemons and other citrus species. Seedless fruit can be induced in many ways, including through self-incompatibility (SI). SI is widely used as an intraspecific reproductive barrier that prevents self-fertilization in flowering plants. Although there have been many studies on SI,... | 25,252,890 | [
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Classical against molecular-genetic methods for susceptibility testing of antituberculotics. | Tuberculosis currently belongs to rare respiratory diseases in Slovakia. However, the emergence and spread of multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are major challenges for global tuberculosis control, since the treatment of resistant forms creates both medical ... | 25,252,893 | [
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Antibiotic consumption pattern in the neonatal special care unit before and after implementation of the hospital's antibiotic policy. | Current and detailed knowledge of antibiotic use is essential in order to implement strategies for reducing the overuse of antibiotics. The objective of our study was to determine the effectiveness of the implementation of the hospital antibiotic policy (HAP) by assessing antibiotic consumption in the Special Neonatal ... | 25,252,896 | [
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Quality of life and health care utilization in patients with chronic respiratory diseases. | High quality of life (QoL) may reduce the costs of medical care of chronically ill patients due to lower health care utilization. The purpose of this study was to establish the influence of the QoL of primary care patients with chronic respiratory diseases on the level of health care utilization and the predictors of h... | 25,252,901 | [
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Development of pod borer-resistant transgenic chickpea using a pod-specific and a constitutive promoter-driven fused cry1Ab/Ac gene. | We studied pod-specific msg promoter from soybean and developed different transgenic lines of chickpea expressing fused cry1Ab/Ac constitutively and pod specifically for resistance against the destructive pest Helicoverpa armigera. Crystal (Cry) proteins derived from the soil bacterium Bacillus thuringiensis (Bt) play ... | 25,252,910 | [
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Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression. | Plasmacytoid dendritic cells (pDC) rapidly and massively produce type I IFN and other inflammatory cytokines in response to foreign nucleic acids, thereby indirectly influencing T-cell responses. Moreover, antigen (Ag)-presenting pDCs directly regulate T-cell differentiation. Depending on the immune environment, pDCs e... | 25,252,912 | [
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A recurrent activating PLCG1 mutation in cardiac angiosarcomas increases apoptosis resistance and invasiveness of endothelial cells. | Primary cardiac angiosarcomas are rare tumors with unfavorable prognosis. Pathogenic driver mutations are largely unknown. We therefore analyzed a collection of cases for genomic aberrations using SNP arrays and targeted next-generation sequencing (tNGS) of oncogenes and tumor-suppressor genes. Recurrent gains of chrom... | 25,252,913 | [
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Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. | Increasing evidence supports the critical roles played by adipose tissue in breast cancer progression. Yet, the mediators and mechanisms are poorly understood. Here, we show that breast cancer-associated adipose tissue from freshly isolated tumors promotes F-actin remodeling, cellular scattering, invasiveness, and sphe... | 25,252,914 | [
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Vitamin D suppresses leptin stimulation of cancer growth through microRNA. | Obesity is a pandemic and major risk factor for cancers. The reduction of obesity would have been an effective strategy for cancer prevention, but the reality is that worldwide obesity has kept increasing for decades, remaining a major avoidable cancer risk secondary only to smoke. The present studies suggest that vita... | 25,252,917 | [
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High-risk anatomic variables and plaque characteristics in carotid artery stenting. | To determine anatomic and plaque-related risk factors for patients undergoing carotid artery stenting. A retrospective review of patients from a prospectively maintained database undergoing carotid artery stenting at our institution between 2001 and 2010 was performed. Preoperative imaging studies (ie, ultrasound, comp... | 25,252,921 | [
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Mapping the Shh long-range regulatory domain. | Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms. The Shh gene and well-established regulators are an example of genomic composition in which enhancers reside in a large desert extending into ne... | 25,252,942 | [
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Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation. | Intratumoral immune activation can induce local and systemic antitumor immunity. Imiquimod is a cream-formulated, TLR7 agonist that is Food and Drug Administration approved for the treatment of nonmelanoma skin cancers, but it has limited activity against melanoma. We studied the antitumor activity and mechanism of act... | 25,252,955 | [
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Anterior and posterior corneal curvature: normal values in healthy Iranian population obtained with the Orbscan II. | The objective of study was to determine the normative values of anterior and posterior best fit sphere (A-BFS and P-BFS) measured with Orbscan II Topography System. In this cross-sectional study, patients (age range: 18-40 years) referred to the Khatam Eye Hospital (Mashhad, Iran) were put in an observational cross-sec... | 25,252,965 | [
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Utility of the N-back task in survivors of childhood acute lymphoblastic leukemia. | The N-back task is often used in functional brain imaging studies to activate working memory networks; however, limited information is available on its association to clinical outcomes in children or cancer survivors. A total of 137 survivors of acute lymphoblastic leukemia (ALL; mean current age = 14.3 years, SD = 4.8... | 25,252,969 | [
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... |
Rb suppresses human cone-precursor-derived retinoblastoma tumours. | Retinoblastoma is a childhood retinal tumour that initiates in response to biallelic RB1 inactivation and loss of functional retinoblastoma (Rb) protein. Although Rb has diverse tumour-suppressor functions and is inactivated in many cancers, germline RB1 mutations predispose to retinoblastoma far more strongly than to ... | 25,252,974 | [
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Regulation of RNA polymerase II activation by histone acetylation in single living cells. | In eukaryotic cells, post-translational histone modifications have an important role in gene regulation. Starting with early work on histone acetylation, a variety of residue-specific modifications have now been linked to RNA polymerase II (RNAP2) activity, but it remains unclear if these markers are active regulators ... | 25,252,976 | [
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Incorporating breast cancer care data into clinical assessment. | Participation in the ONS Foundation-supported Breast Cancer Care Quality Measures Set pilot study was an opportunity for staff at a National Cancer Institute-designated comprehensive cancer center to improve their process for introducing a change in practice. The institution's treatment area revised a documentation too... | 25,252,988 | [
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[Elution properties of linezolid bone cement]. | To explore the elution properties of linezolid bone cement so as to guide the clinical application of linezolid bone cement in the treatment of infection after total joint arthroplasty. The specimens of bone cement (40 g each) were divided into 6 groups depending on mixed different contents with linezolid (5 specimens ... | 25,253,015 | [
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β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network. | Recent histopathological studies have shown that neurodegenerative processes in Alzheimer's and Parkinson's Disease develop along neuronal networks and that hallmarks could propagate trans-synaptically through neuronal pathways. The underlying molecular mechanisms are still unknown, and investigations have been impeded... | 25,253,021 | [
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Receiving Instrumental Support in Late Parent-Child Relationships and Parental Depression. | This study investigates the role of gender, functional limitations, and social interaction in the association between instrumental support from adult children and parental depression. We apply self-determination theory to hypothesize about the role of physical needs and social resources on parental depression in a Euro... | 25,253,024 | [
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The Healthy Lifestyle and Personal Control Questionnaire (HLPCQ): a novel tool for assessing self-empowerment through a constellation of daily activities. | The main goal of stress management and health promotion programs is to improve health by empowering people to take control over their lives. Daily health-related lifestyle choices are integral targets of these interventions and critical to evaluating their efficacy. To date, concepts such as self-efficacy, self-control... | 25,253,039 | [
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Biofilm bacterial communities in urban drinking water distribution systems transporting waters with different purification strategies. | Biofilm formation in drinking water distribution systems (DWDS) has many adverse consequences. Knowledge of microbial community structure of DWDS biofilm can aid in the design of an effective control strategy. However, biofilm bacterial community in real DWDS and the impact of drinking water purification strategy remai... | 25,253,043 | [
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Diffusive and non-diffusive photo-induced proton coupled electron transfer from hydrogen bonded phenols to meso-tetrakis-5,10,15,20-pentafluorophenyl porphyrin. | Enhanced reductive fluorescence quenching of meso-tetrakis-5,10,15,20-pentafluorophenyl porphyrin (H2F20TPP) by two different phenols, 4-methoxy phenol (4-MeOPhOH) and 2,6-dimethoxy phenol (2,6-DiMeOPhOH) in the presence of various pyridine bases in dichloromethane solution is studied using steady state and time resolv... | 25,253,044 | [
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Immobilization of phosphorus from water and sediment using zirconium-modified zeolites. | Adding sorbents to sediments has been suggested as an effective technology for contaminated sediment remediation. In this study, a zirconium-modified zeolite (ZrMZ) was prepared, characterized, and used as a sediment amendment to control phosphorus (P) release from eutrophic lake sediments. The efficiency of ZrMZ in im... | 25,253,056 | [
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Therapeutic effects of tibial support braces on posterior stability after posterior cruciate ligament reconstruction with autogenous hamstring tendon graft. | In the patients who have to be in supine position for most of the time after posterior cruciate ligament (PCL) reconstruction, the tibia tends to shift backwards due to the gravity of the lower leg and the tensed hamstring muscle. To observe the effects of tibial support braces on rehabilitation after PCL reconstructio... | 25,253,078 | [
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Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology. | The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells with constitutively act... | 25,253,080 | [
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-0.02965276,
-0.09646012,
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-0.1219176,
-0.1789043,
0.152129,
0.1717726,
0.01846843,
-0.00537408... |
A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data. | Intra-tumor heterogeneity reflects cancer genome evolution and provides key information for diagnosis and treatment. When bulk tumor tissues are profiled for somatic copy number alterations (sCNA) and point mutations, it may be difficult to estimate their cellular fractions when a mutation falls within a sCNA. We prese... | 25,253,082 | [
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Exploring different types of Hatha yoga for patients with cancer. | Yoga has been practiced for more than 5,000 years and is based on the collective experiences of yoga practitioners over time. Western countries and sophisticated medical facilities use this practice as a complementary therapy with standard medical treatments. Yoga has been shown to improve quality of life. Several type... | 25,253,113 | [
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0.2905006,
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Nursing expertise and the evaluation of psychosocial distress in patients with cancer and survivors. | The number of cancer survivors in the United States will continue to grow because of improved screening, early detection practices, and advances in treatment. The cancer experience has a significant impact on the patient and his or her family, which increases the risk for psychosocial distress. Untreated distress exper... | 25,253,116 | [
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Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study. | In acute cough patients, impaired lung function as present in chronic lung conditions like asthma and chronic obstructive pulmonary disease (COPD) are often thought to negatively influence course of disease, but clear evidence is lacking. To investigate the influence of lung function abnormalities on course of disease ... | 25,253,123 | [
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Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. | Several genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1-PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2-MORC4 loci (rs7057398 in RIPPLY1 and rs12... | 25,253,127 | [
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Examination of whole cell galectin binding by solid phase and flow cytometric analysis. | We have utilized simple flow cytometric and fluorescence-based solid phase assays to study the interaction of glycan-binding proteins (GBP) to cell surface glycoconjugates. These methods utilize commonly employed flow cytometry techniques and commercially available streptavidin-coated microplates to immobilize various ... | 25,253,135 | [
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Methods for assessing the effects of galectins on leukocyte trafficking. | Numerous protocols exist for investigating leukocyte recruitment both in vitro and in vivo. Here we describe three of these methods; an in vitro flow chamber assay, intravital microscopy, and zymosan-induced peritonitis, and give details as to how they can be used to study the actions of galectins on this crucial proce... | 25,253,138 | [
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0.304053,
0.08245... |
Examination of the role of galectins in plasma cell differentiation. | Plasma cells are terminally differentiated B cells that develop via the stimulation of mature B cells with various agents such as antigens and mitogens. Recently, we found that plasma cell differentiation can be modulated by galectin-1 and galectin-8; these galectins appear to play additive and redundant roles in promo... | 25,253,139 | [
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... |
A novel, stable, aqueous glucagon formulation using ferulic acid as an excipient. | Commercial glucagon is unstable due to aggregation and degradation. In closed-loop studies, it must be reconstituted frequently. For use in a portable pump for 3 days, a more stable preparation is required. At alkaline pH, curcumin inhibited glucagon aggregation. However, curcumin is not sufficiently stable for long-te... | 25,253,164 | [
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0.06420517,
0.2655918,
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... |
Informant agreement for youth with autism spectrum disorder or intellectual disability: a meta-analysis. | This study investigated informant agreement on emotional and behavior problems and social skills in youth with autism spectrum disorder or intellectual disability using meta-analytic methods. Forty-nine studies were included, consisting of 107 effect sizes. The mean weighted effect size across all raters and all behavi... | 25,253,177 | [
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0.1328831,
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ILP-based maximum likelihood genome scaffolding. | Interest in de novo genome assembly has been renewed in the past decade due to rapid advances in high-throughput sequencing (HTS) technologies which generate relatively short reads resulting in highly fragmented assemblies consisting of contigs. Additional long-range linkage information is typically used to orient, ord... | 25,253,180 | [
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0.1909583,
0.01189005,
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Building capacity to improve respiratory care: the education strategy of the International Primary Care Respiratory Group 2014-2020. | Significant attention has been given to the global burden of noncommunicable diseases including respiratory diseases and the potential of primary care to address this challenge. The International Primary Care Respiratory Group (IPCRG) has a potentially significant role to build capacity through research and education i... | 25,253,230 | [
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Akt recruits Dab2 to albumin endocytosis in the proximal tubule. | Proximal tubule epithelial cells have a highly sophisticated endocytic machinery to retrieve the albumin in the glomerular filtrate. The megalin-cubilin complex and the endocytic adaptor disabled-2 (Dab2) play a pivotal role in albumin endocytosis. We previously demonstrated that protein kinase B (Akt) regulates albumi... | 25,253,241 | [
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0.05581003,
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Luminex(®) multiplex bead suspension arrays for the detection and serotyping of Salmonella spp. | In this chapter we describe two commercially available bead-based molecular assays for detection, identification and serotyping of Salmonella. The xTAG(®) Gastrointestinal Pathogen Panel (GPP) is a qualitative multiplex test for the simultaneous detection of nucleic acids from Salmonella plus 14 other gastroenteritis-c... | 25,253,245 | [
-0.07699782,
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Study of the Stn protein in Salmonella; a regulator of membrane composition and integrity. | Our studies were undertaken to develop new insights into the function of the Salmonella Stn protein. An analysis of total cell membrane protein fraction suggested the possibility that Stn associates with OmpA. This possibility was confirmed by immunogold labeling using anti-OmpA antibody and far-western blotting. From ... | 25,253,253 | [
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... |
Live cell imaging of intracellular Salmonella enterica. | During the intracellular phase of the pathogenic lifestyle, Salmonella enterica massively alters the endosomal system of its host cells. Two hallmarks are the remodeling of phagosomes into the Salmonella-containing vacuole (SCV) as a replicative niche, and the formation of tubular structures, such as Salmonella-induced... | 25,253,257 | [
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In vitro modeling of gallbladder-associated Salmonella spp. colonization. | The host-pathogen interactions occurring in the gallbladder during Salmonella Typhi colonization contribute to typhoid fever pathogenesis during the acute and chronic stages of disease. The gallbladder is the primary reservoir during chronic typhoid carriage. In this organ, Salmonella encounters host-barriers including... | 25,253,258 | [
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