title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Development of an online sulfur-oxidizing bacteria biosensor for the monitoring of water toxicity. | A toxicity monitoring system based on the metabolic properties of sulfur-oxidizing bacteria (SOB) in continuous and fed-batch modes has been applied for the detection of nitrite (NO2 (-)-N). In this study, the effects of different concentrations of NO2 (-)-N (0.1 to 5 mg/L) on the SOB bioreactors were tested. We found ... | 25,253,265 | [
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Novel approaches for the treatment of psychostimulant and opioid abuse - focus on opioid receptor-based therapies. | Psychostimulant and opioid addiction are poorly treated. The majority of abstinent users relapse back to drug-taking within a year of abstinence, making 'anti-relapse' therapies the focus of much current research. There are two fundamental challenges to developing novel treatments for drug addiction. First, there are t... | 25,253,272 | [
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Comparison of the safety and efficacy of anterior 'skip' corpectomy versus posterior decompression in the treatment of cervical spondylotic myelopathy. | The aim of this study was to compare the therapeutic effects of anterior 'skip' corpectomy with posterior decompression for treating four-level cervical spondylotic myelopathy. Operation time and blood loss during the operation for the anterior and posterior approach groups were recorded. Patients were examined with ce... | 25,253,289 | [
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Putting the 6Cs into Practice: Conversation Cards Holt Lynda Putting the 6Cs into Practice: Conversation Cards £14.99 9780992693848 0992693845 Fink in Organisations Second edition 52 cards [Formula: see text]. | IN ITS drive to ensure core values are at the heart of the NHS and the public health and care sectors, the Department of Health produced a three-year vision and strategy for nursing, midwifery and care staff aimed at compassion in practice. | 25,253,321 | [
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Does self-scheduling increase nurses' job satisfaction? An integrative literature review. | Flexible work schedules give nurses the freedom and control to manage the demands of work and home, allow organisations to meet their staffing needs and can improve job satisfaction. This article reports the results of an integrative review of published peer-reviewed research and personal narratives that examined nurse... | 25,253,331 | [
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Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies. | The HIV-1 surface envelope glycoprotein (Env) trimer mediates entry into CD4(+) CCR5(+) host cells. Env possesses conserved antigenic determinants, such as the gp120 primary receptor CD4 binding site (CD4bs), a known neutralization target. Env also contains variable regions and protein surfaces occluded within the trim... | 25,253,346 | [
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Ascites and spontaneous bacterial peritonitis: recommendations from two United States centers. | Cirrhosis affects millions of people throughout the world. Two of the most serious complications of liver cirrhosis are ascites and spontaneous bacterial peritonitis (SBP). The development of ascites is related to the severity of portal hypertension and is an indicator of increased mortality. Although sodium restrictio... | 25,253,362 | [
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Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats. | Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-α) s... | 25,253,365 | [
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Heteroarylboronates in rhodium-catalyzed 1,4-addition to enones. | Rhodium(I)-catalyzed 1,4-addition of aryl and alkenylboronic acids to α,β-unsaturated carbonyl compounds is well established, but the transfer of heteroaryl residues in this reaction remains underdeveloped. We have studied heteroaryl MIDA and pinacol boronates as alternatives to the labile boronic acid counterparts. Un... | 25,253,388 | [
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Sequence-motif detection of NAD(P)-binding proteins: discovery of a unique antibacterial drug target. | Many enzymes use nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphate (NAD(P)) as essential coenzymes. These enzymes often do not share significant sequence identity and cannot be easily detected by sequence homology. Previously, we determined all distinct locally conserved pyrophosphate-bin... | 25,253,464 | [
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Dynamic changes of twitchlike responses to successive stimuli studied by decomposition of motor unit tetanic contractions in rat medial gastrocnemius. | Unfused tetanic contractions evoked by trains of stimuli at variable interpulse intervals (IPIs) were recorded for 10 fast fatigable (FF), 10 fast resistant (FR), and 10 slow (S) motor units (MUs) and subsequently decomposed with a mathematical algorithm into trains of twitch-shape responses to successive stimuli. The ... | 25,253,476 | [
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The neural basis of tactile motion perception. | The manipulation of objects commonly involves motion between object and skin. In this review, we discuss the neural basis of tactile motion perception and its similarities with its visual counterpart. First, much like in vision, the perception of tactile motion relies on the processing of spatiotemporal patterns of act... | 25,253,479 | [
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Acute onset and rapid progression of multiple organ failure in a young adult with undiagnosed disseminated colonic adenocarcinoma. | Colourectal cancer (CRC) is the fourth most common cause of death from cancer worldwide. While rates for CRC in adults age 50 and older have been declining, incidence rates in young adults, a population routinely not screened, has been increasing. We report a rare case of high-grade CRC in a previously healthy 27-year-... | 25,253,481 | [
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Bifidobacterium--friend or foe? A case of urinary tract infection with Bifidobacterium species. | Bifidobacterium-a commensal of the human intestine is considered non-pathogenic and has been advocated as a probiotic due to its potential beneficial effects. However, there have been case reports implicating bifidobacteria as pathogenic agents in a variety of different infectious conditions. We discuss here one such c... | 25,253,483 | [
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Musical hallucinations responding to a further increase of carbamazepine. | A 73-year-old woman outpatient with mild cognitive impairment, parasomnia and depressive state with musical hallucinations failed to respond to 400 mg/day of valproate. Once she was admitted to a university hospital, her musical hallucinations partially responded to 1 mg/day of clonazepam and sufficiently improved on 1... | 25,253,486 | [
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The perception of nanotechnology and nanomedicine: a worldwide social media study. | We explore at a world level the awareness of nanotechnology expressed through the most popular online social media: Facebook. We aimed at identifying future trends, the most interested countries and the public perception of ethics, funding and economic issues. We found that graphene and carbon nanotubes are the most fo... | 25,253,496 | [
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Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment. | Combination therapy for cancer patients is an important standard of care protocol because it can elicit synergistic therapeutic effects and reduce systemic toxicity by simultaneously modulating multiple cell-signaling pathways and overcoming multidrug resistance. Nanocarriers are expected to play a major role in delive... | 25,253,498 | [
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Synthetic and bioinspired cage nanoparticles for drug delivery. | Nanotechnology has the potential to revolutionize drug delivery, but still faces some limitations. One of the main issues regarding conventional nanoparticles is their poor drug-loading and their early burst release. Thus, to overcome these problems, researchers have taken advantage of the host-guest interactions that ... | 25,253,501 | [
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Conduction abnormality and arrhythmia after transcatheter closure of atrial septal defect. | The aim of this study was to prospectively perform ambulatory 24-h ECG monitoring to assess the effects of transcatheter closure of atrial septal defect (ASD). A total of 235 consecutive subjects (female, n=163; male, n=72; age, 44.6±14.4 years) were enrolled in the study, who were due undergo ASD closure. Holter monit... | 25,253,507 | [
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Probing the rate-limiting step for intramolecular transfer of a transcription factor between specific sites on the same DNA molecule by (15)Nz-exchange NMR spectroscopy. | The kinetics of translocation of the homeodomain transcription factor HoxD9 between specific sites of the same or opposite polarities on the same DNA molecule have been studied by (15)Nz-exchange NMR spectroscopy. We show that exchange occurs by two facilitated diffusion mechanisms: a second-order intermolecular exchan... | 25,253,516 | [
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Immunological disorders of diabetes mellitus in experimental rat models. | A comprehensive understanding of the pathogenic mechanism is the prerequisite for proper disease management. However, the mechanisms of diabetes mellitus and diabetic complication remain extremely complicated and unresolved. While immune reactions are involved in the pathogenesis of diabetes and diabetic complication, ... | 25,253,518 | [
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Delineating fibronectin bioadhesive micropatterns by photochemical immobilization of polystyrene and poly(vinylpyrrolidone). | Bioadhesive micropatterns, capable of laterally confining cells to a 2D lattice, have proven effective in simulating the in vivo tissue environment. They reveal fundamental aspects of the role of adhesion in cell mechanics, proliferation, and differentiation. Here we present an approach based on photochemistry for the ... | 25,253,530 | [
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Novel N-amidinopiperidine-based proteasome inhibitor preserves dendritic cell functionality and rescues their Th1-polarizing capacity in Ramos-conditioned tumor environment. | The tumor microenvironment represents a burden that hampers the proper activation of immune cells, including the dendritic cells (DCs). It is, therefore, desired that the important characteristics of a given anticancer drug candidate be seen as consisting not solely of its antitumor properties, but that it also lacks p... | 25,253,531 | [
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Direct enzyme-substrate affinity determination by real-time hyperpolarized (13)C-MRS. | A specialized kinetic analysis of real-time hyperpolarized [1,1,2,2-D4, 1-(13)C]choline (13)C-magnetic resonance spectroscopy enabled the determination of initial rates of metabolic enzyme activity (choline oxidase), enzyme-substrate affinity (Km), and inhibition. In a clinical MRI scanner, metabolite levels lower than... | 25,253,534 | [
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Correlation analysis of STAT3 and VEGF expression and eosinophil infiltration in nasal polyps. | The expression and distribution of signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), and vascular endothelial growth factor (VEGF), as well as eosinophil infiltration in nasal polyps was detected to examine their roles and correlations in the nasal polyp pathogenesis. Using the... | 25,253,546 | [
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Multifocal electroretinography in subjects with age-related macular degeneration. | To evaluate retinal function objectively in subjects with different stages of age-related macular degeneration (AMD) using multifocal electroretinography (mfERG) and compare it with age-matched control group. A total of 42 subjects with AMD and 37 age-matched healthy control group aged over 55 years were included in th... | 25,253,559 | [
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Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome. | Antiphospholipid syndrome (APS) is an autoimmune condition that is diagnosed by the presence of at least one of the clinical manifestations (thrombosis and/or pregnancy failure) and one of antiphospholipid antibodies (aPL) laboratory tests. The most relevant aPL are lupus anticoagulant (LA), anti-beta2 glycoprotein I (... | 25,253,571 | [
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Current and investigational drugs for the prevention of migraine in adults and children. | There are only a handful of drugs that have been submitted for and received an indication for the preventative treatment of migraine by the US Food and Drug Administration, as well as international governmental regulatory agencies. However, there are a wide variety of agents that are used for this indication with diffe... | 25,253,573 | [
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Structure-based inhibition of protein-protein interactions. | Protein-protein interactions (PPIs) are emerging as attractive targets for drug design because of their central role in directing normal and aberrant cellular functions. These interactions were once considered "undruggable" because their large and dynamic interfaces make small molecule inhibitor design challenging. How... | 25,253,637 | [
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Effects of neonatal exposure to the flame retardant tetrabromobisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term potentiation and synaptic protein levels in mice. | Brominated flame retardants such as tetrabromobisphenol-A (TBBPA) may exert (developmental) neurotoxic effects. However, data on (neuro)toxicity of halogen-free flame retardants (HFFRs) are scarce. Recent in vitro studies indicated a high neurotoxic potential for some HFFRs, e.g., zinc stannate (ZS), whereas the neurot... | 25,253,649 | [
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Phase I/II randomized trial of safety and immunogenicity of LIPO-5 alone, ALVAC-HIV (vCP1452) alone, and ALVAC-HIV (vCP1452) prime/LIPO-5 boost in healthy, HIV-1-uninfected adult participants. | Finding an effective human immunodeficiency virus type 1 (HIV-1) vaccine remains a major global health priority. In a phase I/II, placebo-controlled trial, healthy, HIV-1-negative adults were randomized to receive one of 5 vaccine regimens: LIPO-5 (combination of 5 lipopeptides) alone (250 μg), ALVAC-HIV (vCP1452) alon... | 25,253,665 | [
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Clinical characteristics and antiretroviral treatment of older HIV-infected patients. | The number of Human Immunodeficiency Virus (HIV) patients aged 50 years or over is growing year on year, due to both late diagnoses and the chronicity of the illness. This increase is a new phenomenon. To describe the clinical and epidemiological characteristics of the older HIV infected population and determine if the... | 25,253,678 | [
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Distinct Patterns of Everyday Executive Function Problems Distinguish Children With Tourette Syndrome From Children With ADHD or Autism Spectrum Disorders. | The aim is to investigate the everyday executive function (EF) in children with Tourette syndrome (TS), Inattentive or Combined presentations of ADHD (ADHD-I/ADHD-C), autism spectrum disorders (ASD), and typically developing children (TDC). Nineteen TS, 33 ADHD-C, 43 ADHD-I, 34 ASD, and 50 TDC participated (8-17 years)... | 25,253,683 | [
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Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway. | The obligate intracellular human pathogen Chlamydia trachomatis is the etiological agent of blinding trachoma and sexually transmitted disease. Genomic sequencing of Chlamydia indicated this medically important bacterium was not exclusively dependent on the host cell for energy. In order for the electron transport chai... | 25,253,688 | [
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Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy. | Renal fibrosis is responsible for progressive renal diseases that cause chronic renal failure. Sfrp1 (secreted Frizzled-related protein 1) is highly expressed in kidney, although little is known about connection between the protein and renal diseases. Here, we focused on Sfrp1 to investigate its roles in renal fibrosis... | 25,253,698 | [
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Coordination and plasticity in leaf anatomical traits of invasive and native vine species. | • Plant invasiveness can be promoted by higher values of adaptive traits (e.g., photosynthetic capacity, biomass accumulation), greater plasticity and coordination of these traits, and by higher and positive relative influence of these functionalities on fitness, such as increasing reproductive output. However, the dat... | 25,253,703 | [
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An agent-based model for mRNA export through the nuclear pore complex. | mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood. The density of export receptors that must bind an mRNA to ensure export, as well as how receptor distribution affects transport dynamics, is not kno... | 25,253,717 | [
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Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | Platelet-activating factor (PAF), a potent phospholipid activator of inflammation that signals through its cognate receptor (platelet-activating factor receptor, PTAFR), has been shown to induce preterm delivery in mice. Toll-like receptors (TLRs) are transmembrane receptors that mediate innate immunity. We have shown ... | 25,253,732 | [
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Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities. | Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are oocyte-secreted paralogs of the transforming growth factor beta (TGFbeta) superfamily. In mammals, these two growth factors play critical roles in folliculogenesis. As previously reported, an arginine in the pre-helix loop of GDF5 defi... | 25,253,739 | [
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Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes. | To measure the reproducibility of retinal oxygen saturation (SaO2) levels among treated glaucomatous eyes and normal controls in a prospective non-randomised study. Patients with perimetric glaucoma (PG) and normal controls were included. Exclusion criteria for both groups included visual acuity <20/30, unreliable v... | 25,253,765 | [
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Triple-negative breast cancer patients treated at MD Anderson Cancer Center in phase I trials: improved outcomes with combination chemotherapy and targeted agents. | Patients with metastatic triple-negative breast cancer (TNBC) have poor treatment outcomes. We reviewed the electronic records of consecutive patients with metastatic TNBC treated in phase I clinic at MD Anderson Cancer Center (Houston, TX) between Augu st 2005 and May 2012. One hundred and six patients received at lea... | 25,253,784 | [
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Clinical laboratory response to a mock outbreak of invasive bacterial infections: a preparedness study. | Large hospital-based clinical laboratories must be prepared to rapidly investigate potential infectious disease outbreaks. To challenge the ability of our molecular diagnostics laboratory to use whole-genome sequencing in a potential outbreak scenario and identify impediments to these efforts, we studied 84 invasive se... | 25,253,790 | [
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A Tradeoff Between Accuracy and Flexibility in a Working Memory Circuit Endowed with Slow Feedback Mechanisms. | Recent studies have shown that reverberation underlying mnemonic persistent activity must be slow, to ensure the stability of a working memory system and to give rise to long neural transients capable of accumulation of information over time. Is the slower the underlying process, the better? To address this question, w... | 25,253,801 | [
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Effects of maternal protein or energy restriction during late gestation on immune status and responses to lipopolysaccharide challenge in postnatal young goats. | Knowledge of maternal malnutrition of ruminants and effects on development of the immune system of their offspring is lacking. A study was conducted to investigate the effects of maternal protein or energy restriction during late gestation on immune status of their offspring at different ages. Sixty-three pregnant goat... | 25,253,814 | [
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Predicting microbial protein synthesis in beef cattle: relationship to intakes of total digestible nutrients and crude protein. | Prediction of microbial CP (MCP) synthesis in the rumen is an integral part of the MP system. For the NRC beef model, MCP is calculated as 0.13 multiplied by TDN intake (TDNI), with adjustment for physically effective NDF (peNDF) concentrations less than 20%. Despite its application for nearly 2 decades, MCP prediction... | 25,253,815 | [
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Characteristics of patients with graves disease and intrathyroid hypovascularity compared to painless thyroiditis. | The purpose of this study was to assess the frequency and sonographic and laboratory characteristics of Graves disease with intrathyroid hypovascularity in Japanese patients and to compare these characteristics in patients with painless thyroiditis. A total of 194 consecutive patients with Graves disease and 21 patient... | 25,253,825 | [
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Targeted neonatal echocardiography services: need for standardized training and quality assurance. | Targeted neonatal echocardiography refers to a focused assessment of myocardial performance and hemodynamics directed by a specific clinical question. It has become the standard of care in many parts of the world, but practice is variable, and there has been a lack of standardized training and evaluation to date. Targe... | 25,253,831 | [
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SonoGames: an innovative approach to emergency medicine resident ultrasound education. | SonoGames was created by the Academy of Emergency Ultrasound for the 2012 annual meeting of the Society for Academic Emergency Medicine. The assessment of resident knowledge and of the performance of point-of-care ultrasound examinations is an integral component of ultrasound education and is required in emergency medi... | 25,253,832 | [
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Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130. | After nerve injury, adult sensory neurons can regenerate peripheral axons and reconnect with their target tissue. Initiation of outgrowth, as well as elongation of neurites over long distances, depends on the signaling of receptors for neurotrophic growth factors. Here, we investigated the importance of gp130, the sign... | 25,253,866 | [
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Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates. | Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance-drug interaction assessment are lacking. This deficiency is due in part to challenges unique to dietary substances, a lack of requisite human-derived dat... | 25,253,884 | [
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Grain setting defect1, encoding a remorin protein, affects the grain setting in rice through regulating plasmodesmatal conductance. | Effective grain filling is one of the key determinants of grain setting in rice (Oryza sativa). Grain setting defect1 (GSD1), which encodes a putative remorin protein, was found to affect grain setting in rice. Investigation of the phenotype of a transfer DNA insertion mutant (gsd1-Dominant) with enhanced GSD1 expressi... | 25,253,885 | [
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Perinatal Risks in "Late Motherhood" Defined Based On Parity and Preterm Birth Rate - an Analysis of the German Perinatal Survey (20th Communication). | <bAim:</b "Late motherhood" is associated with greater perinatal risks but the term lacks precise definition. We present an approach to determine what "late motherhood" associated with "high risk" is, based on parity and preterm birth rate. <bMaterials and Methods:</b Using data from the German Perinatal Survey of 1998... | 25,253,904 | [
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The Effect of High Dose Methylprednisolone on Experimental Ovarian Torsion/Reperfusion Injury in Rats. | <bPurpose:</b Aim of the study was to evaluate the effects of high dose methylprednisolone on experimental ovarian torsion-detorsion injury in rats. <bMaterials and Methods:</b Twenty-two Sprague-Dawley rats were randomly divided into three groups. Group 1 (ischemia group, 8 rats) were subjected to left adnexal torsion... | 25,253,907 | [
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Toxicological and pathological review of concurrent occurrence of nitrite toxicity and Swine Fever in pigs. | Plant associated nitrate/nitrite poisoning in buffalo, cattle, goat and sheep had been reported from various parts of the world. Horses and pigs are considered less susceptible to nitrate poisoning. In this study epidemiology of rare outbreak of nitrate poisoning in combination with classical swine fever in a small pig... | 25,253,929 | [
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0.0856746,
0.6473421,
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... |
Pharmacodynamic Interaction of Green Tea Extract with Hydrochlorothiazide against Cyclophosphamide-Induced Myocardial Damage. | Treatment of ischemic hypertensive patients with hydrochlorothiazide can precipitate cardiac arrhythmias. Green tea by virtue of its antioxidant potential is responsible for cardio-protective activity. The present study was undertaken to evaluate the pharmacodynamic interaction of green tea extract with hydrochlorothia... | 25,253,931 | [
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A study of clinical profile of snake bite at a tertiary care centre. | Snake bite is an important occupational and rural hazard because India has always been a land of Exotic snakes. In Maharashtra, common poisonous snakes are Cobra, Russell's Viper, Saw Scaled Viper, and Krait. It is a fact that inspite of heavy morbidity and mortality, very little attention is paid by the clinicians to ... | 25,253,932 | [
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0.5267835,
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Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training. | To evaluate the efficacy of botulinum toxin type A injection to the puborectalis and external sphincter muscle in the treatment of patients with anismus unresponsive to simple biofeedback training. This retrospective study included 31 patients suffering from anismus who were unresponsive to simple biofeedback training.... | 25,253,964 | [
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Successful esophagectomy in a patient with combined esophageal cancer and hemophilia B. | Patients with esophageal cancer often require esophagectomy with esophagogastrostomy. However, the incidence of complications, such as hemorrhage, during operations for esophageal cancer is high, even with minimally invasive surgery. Without the appropriate interventions, the risk of major intraoperative and postoperat... | 25,253,980 | [
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Multiplex bead array assay of plasma cytokines in type 2 diabetes mellitus with diabetic retinopathy. | The aim of this study was to assess the roles of plasma cytokines in diabetic retinopathy (DR) and their relationship with the severity of DR. This study included 59 diabetic patients and 19 non-diabetic controls. The plasma concentrations of endothelial growth factor (EGF), eotaxin, fibroblast growth factor 2 (FGF-2),... | 25,253,986 | [
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Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. | Androgenetic alopecia (AGA) is the most common form of hair loss. Clinically observed hair loss is due to the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesi... | 25,254,005 | [
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Impact of chronic kidney disease and anemia on physical function in patients with chronic heart failure. | The aim of this study was to confirm the effects of chronic kidney disease (CKD) and anemia on physical function and to clarify whether the interaction between CKD and anemia has an additive effect. Eligible subjects were chronic heart failure (HF) patients who were discharged between March 2007 and August 2009. A tota... | 25,254,028 | [
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Aging and others' pain processing: implications for hospitalization. | Objectives. While self-pain perception has been widely investigated in aging, the perception as well as memory of pain in others has received little attention. Methods. The study was designed as a cross-sectional behavioral study in which a group of 41 younger and a group of 41 older adults evaluated a series of valenc... | 25,254,040 | [
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Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid. | Background. Most patients with a preoperative diagnosis of thyroid follicular neoplasm (FN) undergo diagnostic surgery to determine whether the nodule is benign or malignant. Point mutations at NRAS codon 61 are the most common mutations observed in FN. However, the clinical significance of NRAS mutation remains unclea... | 25,254,041 | [
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Positive relationship between total antioxidant status and chemokines observed in adults. | Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults. We as... | 25,254,081 | [
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Resolving the paradox for protein aggregation diseases: a common mechanism for aggregated proteins to initially attack membranes without needing aggregates. | Paradoxically, aggregation of specific proteins is characteristic of many human diseases and aging, yet aggregates have been found to be unnecessary for initiating pathogenesis. Here we determined the NMR topology and dynamics of a helical mutant in a membrane environment transformed from the 125-residue cytosolic all-... | 25,254,094 | [
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An analysis on the entity annotations in biological corpora. | Collection of documents annotated with semantic entities and relationships are crucial resources to support development and evaluation of text mining solutions for the biomedical domain. Here I present an overview of 36 corpora and show an analysis on the semantic annotations they contain. Annotations for entity types ... | 25,254,099 | [
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Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients. | Some somatic single nucleotide variants (SNVs) are thought to be pathogenic, leading to neurological disease. We hypothesized that heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), an autoantigen associated with multiple sclerosis (MS) would contain SNVs. MS patients develop antibodies to hnRNP A1 (293-304), an ... | 25,254,102 | [
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False memory susceptibility is correlated with categorisation ability in humans. | Our memory is often surprisingly inaccurate, with errors ranging from misremembering minor details of events to generating illusory memories of entire episodes. The pervasiveness of such false memories generates a puzzle: in the face of selection pressure for accuracy of memory, how could such systematic failures have ... | 25,254,105 | [
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Strategies of the honeybee Apis mellifera during visual search for vertical targets presented at various heights: a role for spatial attention? | When honeybees are presented with a colour discrimination task, they tend to choose swiftly and accurately when objects are presented in the ventral part of their frontal visual field. In contrast, poor performance is observed when objects appear in the dorsal part. Here we investigate if this asymmetry is caused by fi... | 25,254,109 | [
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A systematic review of cognitive remediation therapy for anorexia nervosa - development, current state and implications for future research and clinical practice. | To systematically review studies of cognitive remediation therapy (CRT) for anorexia nervosa (AN), and to discuss findings with references to clinical practice and future research. The literature was reviewed using the PubMed, Web of Science and PsycINFO search terms "cognitive remediation therapy" AND "anorexia nervos... | 25,254,110 | [
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Perceived cognitive decline in multiple sclerosis impacts quality of life independently of depression. | Background/Aim. The aim of this study is to examine the effects of perceived cognitive dysfunction and of depression, on self-reported QoL, in a Greek population sample of MS patients. Methods. One hundred outpatients diagnosed with MS completed the Short-Form-36 Health Survey (SF-36), as well as the Perceived Deficits... | 25,254,118 | [
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Modulation at age of onset in tunisian huntington disease patients: implication of new modifier genes. | Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The causative mutation is an expansion of more than 36 CAG repeats in the first exon of IT15 gene. Many studies have shown that the IT15 interacts with several modifier genes to regulate the age at onset (AO) of HD. Our study aims to investi... | 25,254,119 | [
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Complete bilateral gemination of maxillary incisors with separate root canals. | Developmental anomalies in the hard tissue are seen frequently in dental practice. Gemination and fusion are the most commonly encountered anomalies, and distinction between the two is always challenging. Gemination, also called double tooth, is an anomaly exhibiting two joined crowns and usually a single root. It repr... | 25,254,121 | [
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A New Approach in Risk Stratification by Coronary CT Angiography. | For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks. CCTA can provide more information incorporating the presence, extent, and severity of CAD; coronary plaque burden; and cha... | 25,254,142 | [
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Silent no more: Endogenous small RNA pathways promote gene expression. | Endogenous small RNA pathways related to RNA interference (RNAi) play a well-documented role in protecting host genomes from the invasion of foreign nucleic acids. In C. elegans, the PIWI type Argonaute, PRG-1, through an association with 21U-RNAs, mediates a genome surveillance process by constantly scanning the genom... | 25,254,148 | [
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Fever management: Evidence vs current practice. | Fever is a very common complaint in children and is the single most common non-trauma-related reason for a visit to the emergency department. Parents are concerned about fever and it's potential complications. The biological value of fever (i.e., whether it is beneficial or harmful) is disputed and it is being vigorous... | 25,254,165 | [
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Oral hygiene and gingival health status of children with Down syndrome in Yemen: A cross-sectional study. | The objective of the present study was to assess the oral hygiene and gingival health status among Yemeni children with Down syndrome. The study sample comprised 101 children with Down syndrome attending special needs schools in Sana'a, Yemen. The calculus index (CI), plaque index (PI), and the gingival index (GI) were... | 25,254,190 | [
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Effectiveness of different tooth brushing techniques on the removal of dental plaque in 6-8 year old children of Gulbarga. | This study was undertaken to evaluate the respective effectiveness of the horizontal scrub, Fones, and modified Bass methods demonstrated on the cast to individual child within the classroom setting. A total of 180 healthy children studying in 1(st) and 2(nd) grades in the age range of 6-8 years were randomly selected ... | 25,254,196 | [
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Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials. | The latest European guidelines for the management of hemorrhagic shock suggest the use of vasopressors (norepinephrine) in order to restore an adequate mean arterial pressure when fluid resuscitation therapy fails to restore blood pressure. The administration of arginine vasopressin (AVP), or its analogue terlipressin,... | 25,254,206 | [
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Autogenerator-based modelling framework for development of strategic games simulations: rational pigs game extended. | When considering strategic games from the conceptual perspective that focuses on the questions of participants' decision-making rationality, the very issues of modelling and simulation are rarely discussed. The well-known Rational Pigs matrix game has been relatively intensively analyzed in terms of reassessment of the... | 25,254,228 | [
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Low complexity mode decision for 3D-HEVC. | High efficiency video coding- (HEVC-) based 3D video coding (3D-HEVC) developed by joint collaborative team on 3D video coding (JCT-3V) for multiview video and depth map is an extension of HEVC standard. In the test model of 3D-HEVC, variable coding unit (CU) size decision and disparity estimation (DE) are introduced t... | 25,254,237 | [
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A synthesized heuristic task scheduling algorithm. | Aiming at the static task scheduling problems in heterogeneous environment, a heuristic task scheduling algorithm named HCPPEFT is proposed. In task prioritizing phase, there are three levels of priority in the algorithm to choose task. First, the critical tasks have the highest priority, secondly the tasks with longer... | 25,254,244 | [
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-0.3627226,
0.3953541,
-0.545022,
0.1807838,
-0.4848788,
-0.03725008,
-0.2643681,
-0.09134149,
-0.01795539,
0.266023,
-0.04506258,... |
A new look at the coefficients of a reciprocal generating function. | We study a special property of free cumulants. We prove that coefficients of a reciprocal generating function correspond to "free cumulants with the first two elements in the same block." | 25,254,253 | [
0.07025107,
0.03710701,
-0.269802,
-0.02482281,
0.03511435,
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0.08989069,
0.204219,
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0.3841936,
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0... |
Network anomaly detection system with optimized DS evidence theory. | Network anomaly detection has been focused on by more people with the fast development of computer network. Some researchers utilized fusion method and DS evidence theory to do network anomaly detection but with low performance, and they did not consider features of network-complicated and varied. To achieve high detec... | 25,254,258 | [
0.2448774,
0.1957836,
0.05381065,
0.01899818,
0.3003855,
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-0.408101,... |
Reflections: Neurology and The Humanities. The case of the locked house. The finished mystery. | After the death in 2012 of Dr. Robert Joynt, who served Neurology® as CPC Section Editor, an unfinished manuscript was found on his computer. It would have been his sixth Sherlock Holmes pastiche. Intrigued by the story but deflated at the lack of an ending, the editors published the case in the September 10, 2013, iss... | 25,254,262 | [
-0.323674,
-0.09619537,
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0.3371472,
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0.1073959,
0.07356472,
0.08771521,
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0.3311483,
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... |
Field note: comparative efficacy of a woody evapotranspiration landfill cover following the removal of aboveground biomass. | Woody vegetation cultivated for moisture management on evapotranspiration (ET) landfill covers could potentially serve a secondary function as a biomass crop. However, research is required to evaluate the extent to which trees could be harvested from ET covers without significantly impacting their moisture management f... | 25,254,294 | [
-0.06115075,
0.2040195,
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0.3110922,
0.182418,
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0.4499202,
0.0265741... |
Proteomic study of pilocytic astrocytoma pediatric brain tumor intracystic fluid. | Liquid chromatography in coupling with high-resolution ESI-LTQ-Orbitrap mass spectrometry was applied for a proteomic study of pediatric pilocytic astrocytoma brain tumor intracystic fluid by an integrated top-down/bottom-up platform. Both of the proteomic strategies resulted complementary and support each other in con... | 25,254,300 | [
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An efficient approach for preprocessing data from a large-scale chemical sensor array. | In this paper, an artificial olfactory system (Electronic Nose) that mimics the biological olfactory system is introduced. The device consists of a Large-Scale Chemical Sensor Array (16; 384 sensors, made of 24 different kinds of conducting polymer materials)that supplies data to software modules, which perform advance... | 25,254,304 | [
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0.12158,
0.1022776,
-0.05182813,
-0.02659572,
-0.1864456,
0.06... |
Barrier properties to surrogates of hydrogenated carbon nano-films deposited on PET by plasma-enhanced chemical vapour deposition. | Poly(ethylene terephthalate) resin was contaminated with a series of surrogates using a US Food and Drug Administration protocol. The contaminated samples were coated with two different kinds of hydrogenated amorphous carbon thin films (a-C:H): one with diamond-like hydrogenated amorphous carbon and another with polyme... | 25,254,307 | [
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0.08252027... |
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. | Long-QT syndrome mutations can cause syncope and sudden death by prolonging the cardiac action potential (AP). Ion channels affected by mutations are various, and the influences of cellular calcium cycling on LQTS cardiac events are unknown. To better understand LQTS arrhythmias, we performed current-clamp and intracel... | 25,254,341 | [
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Centre-based day care for children younger than five years of age in low- and middle-income countries. | Because of poverty, children and families in low- and middle-income countries often face significant impediments to health and well-being. Centre-based day care services may influence the development of children and the economic situation of parents by providing good quality early childhood care and by freeing parents ... | 25,254,354 | [
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0.1997529,
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0.1148733,
0.3518998,
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0.3230226,
-0.02557935,
0.2254177,
-0.11721... |
Controlled incremental filtration: a simplified approach to design and fabrication of high-throughput microfluidic devices for selective enrichment of particles. | The number of microfluidic strategies aimed at separating particles or cells of a specific size within a continuous flow system continues to grow. The wide array of biomedical and other applications that would benefit from successful development of such technology has motivated the extensive research in this area over ... | 25,254,358 | [
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0.3013934,
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Evaluation of biochemical, hematological and parasitological parameters of protein-deficient hamsters infected with Ancylostoma ceylanicum. | Hookworms infect millions of people worldwide and can cause severe clinical symptoms in their hosts. Prospective cohort studies in Brazil show high rates of hookworm reinfection in malnourished children compared to well-nourished children, despite previous treatment. Additionally, soil-transmitted helminth (STH) infect... | 25,254,370 | [
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0.1065146,
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0.4224091,
-0.19653... |
Systemic hypertension as a risk factor for open-angle glaucoma: a meta-analysis of population-based studies. | Systemic hypertension is thought to increase the risk for developing open-angle glaucoma (OAG) through several mechanisms. However, previous epidemiological studies have shown conflicting results regarding this potential association. We systematically evaluated this issue by conducting a meta-analysis of population-bas... | 25,254,373 | [
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... |
Selection of nectar plants for use in ecological engineering to promote biological control of rice pests by the predatory bug, Cyrtorhinus lividipennis, (Heteroptera: Miridae). | Ecological engineering for pest management involves the identification of optimal forms of botanical diversity to incorporate into a farming system to suppress pests, by promoting their natural enemies. Whilst this approach has been extensively researched in many temperate crop systems, much less has been done for rice... | 25,254,377 | [
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0.1304279,
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0.152511,
0.42304,
-0.1302189... |
Household transmission of influenza A(H1N1)pdm09 in the pandemic and post-pandemic seasons. | The transmission of influenza viruses occurs person to person and is facilitated by contacts within enclosed environments such as households. The aim of this study was to evaluate secondary attack rates and factors associated with household transmission of laboratory-confirmed influenza A(H1N1)pdm09 in the pandemic and... | 25,254,376 | [
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0.13023,
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... |
Sedative-hypnotics are widely abused by drivers apprehended for driving under the influence of drugs. | Sedative-hypnotics are commonly encountered in drivers apprehended for driving under the influence of drugs (DUID). Previous research has mainly concentrated on the residual effects of the drugs. In this study, the extent of sleep medication use and abuse among drivers apprehended on suspicion of DUID was assessed. Add... | 25,254,415 | [
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0.03838779,
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... |
Development of a population PK model of tacrolimus for adaptive dosage control in stable kidney transplant patients. | Tacrolimus pharmacokinetics (PK) presents a high variability that hampers its therapeutic use. The aims of this study are to: (1) develop a population pharmacokinetic (PPK) model for tacrolimus and to identify the factors that contribute to the variability of tacrolimus PK in renal transplant patients; and (2) to estab... | 25,254,416 | [
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0.2405551,
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SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. | SAM-pointed domain-containing ETS transcription factor (SPDEF) is expressed in normal prostate epithelium. While its expression changes during prostate carcinogenesis (PCa), the role of SPDEF in prostate cancer remains controversial due to the lack of genetic mouse models. In present study, we generated transgenic mice... | 25,254,494 | [
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Rapid determination of cell mass and density using digitally controlled electric field in a microfluidic chip. | The density of a single cell is a fundamental property of cells. Cells in the same cycle phase have similar volume, but the differences in their mass and density could elucidate each cell's physiological state. Here we report a novel technique to rapidly measure the density and mass of a single cell using an optically ... | 25,254,511 | [
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0.09175666,
0.06207911,
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0.4184324,
0.1609533,
-0.020911... |
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