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Hepatitis C virus genotype distribution in Turkey remains unchanged after a decade: performance of phylogenetic analysis of the NS5B, E1, and 5'UTR regions in genotyping efficiency.
Hepatitis C virus (HCV) genotyping has a considerable effect on therapy. The aim was to determine the change in prevalence of HCV genotypes in Turkey during the last decade and to compare the performance of DNA sequencing of different targets in the HCV genome (NS5B, E1, and 5'UTR). Five hundred HCV RNA-positive patien...
25,254,523
[ 0.05198399, 0.06474131, -0.08686824, -0.005185695, 0.1799424, -0.1697047, -0.04814534, 0.05578526, -0.01312249, 0.02036652, 0.07890669, 0.01633085, 0.1297498, 0.2485783, -0.1560901, -0.1106823, 0.08670584, 0.1479718, 0.3013196, 0.07080546, 0.260276, 0.09972032, 0.00800873...
Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension.
Pulmonary arterial hypertension (PAH) that occurs in the setting of cirrhosis and portal hypertension is referred to as portopulmonary hypertension (PPHTN). Liver transplantation (LTx) is curative, but the presence of moderate-to-severe PPHTN may be a contraindication for transplantation because of the elevated risk of...
25,254,528
[ 0.03455498, -0.03179017, -0.1935116, -0.01232948, 0.1469886, 0.1225013, 0.06151428, -0.0213047, -0.0811369, 0.03493387, 0.161777, 0.02261123, -0.1870297, 0.04247476, -0.3905666, -0.2348003, -0.1041175, 0.0799423, 0.06454043, -0.06681811, 0.02079961, 0.5227214, 0.06181836,...
Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma: CRHR1 as a potent prognostic factor.
Corticotropin-releasing hormone (CRH), a major regulator of the stress response, regulates various biological functions through its interaction with CRH receptors 1 (CRHR1) and 2 (CRHR2). CRH, CRHR1, and CRHR2 have recently been reported in several types of carcinoma, but the significance of these proteins has remained...
25,254,562
[ 0.1891228, -0.2777379, 0.09451172, -0.2753941, -0.2362584, -0.140773, 0.1296443, 0.2793103, 0.2726288, 0.3100853, 0.2985038, -0.1124752, -0.27008, -0.0704933, 0.01388581, -0.3073177, 0.2243929, 0.169761, 0.1567601, 0.2348474, 0.1372321, 0.2358955, -0.2630866, -0.0608114...
The association of direct thrombin inhibitor anticoagulants with cardiac thromboses.
Direct thrombin inhibitor (anti-factor IIa) anticoagulants, now established for treatment and prevention of cardiac thromboembolism and VTE, have been repeatedly associated with a significantly increased frequency of thrombosis on abnormal cardiac endothelium when compared head-to-head with indirectly acting therapeuti...
25,254,608
[ 0.05905704, 0.2583573, -0.1283179, -0.1970018, 0.2306105, -0.02527179, 0.2085239, 0.1771386, -0.2362362, 0.05328011, 0.001226467, 0.3601122, 0.1119448, -0.2193622, -0.01771907, 0.0003001005, -0.2777851, 0.03689807, -0.05506515, 0.06614555, 0.1252142, 0.2471527, -0.1914693...
Suicide by gases in England and Wales 2001-2011: evidence of the emergence of new methods of suicide.
Increases in suicide deaths by gassing, particularly carbon monoxide poisoning from burning barbecue charcoal, have occurred in many parts of East Asia and resulted in rises in overall suicide rates in some countries. Recent trends in gas poisoning suicides outside Asia have received little attention. We analysed suici...
25,254,616
[ -0.5730509, 0.272774, 0.2080465, 0.1281398, -0.1761314, 0.07179167, -0.3389378, -0.5606151, -0.1355718, 0.2356347, 0.1514456, 0.05395068, -0.0008322218, 0.2700126, 0.2370071, -0.2428874, 0.2081825, 0.1442971, 0.5839663, -0.01855086, -0.07856029, 0.5637137, -0.1368784, -...
Novel approaches to combat bacterial biofilms.
Biofilms formed by pathogenic bacteria and fungi are associated with a wide range of diseases, from device-related infections (such as catheters or prosthetic joints) to chronic infections occurring on native tissues (such as lung infections in cystic fibrosis patients). Biofilms are therefore responsible for an import...
25,254,624
[ -0.03538279, 0.2109367, 0.1781314, 0.2496626, -0.2051969, 0.01164379, -0.1348244, 0.119734, 0.03537396, -0.02428067, 0.001192116, -0.1240235, -0.05481606, -0.01386334, -0.2217893, 0.07297298, -0.504616, 0.2784867, 0.002317794, -0.09448456, 0.05206196, 0.1160009, -0.135665...
A rapid, sensitive and selective electrochemical biosensor with concanavalin A for the preemptive detection of norovirus.
Norovirus (NoV) is a foodborne pathogen that can cause sporadic and epidemic gastrointestinal diseases. Rapid screening is crucial to promptly identify the presence of NoV and prevent food poisoning. Here, we present a sensitive, selective, and rapid electrochemical biosensor for the detection of NoV. The proposed elec...
25,254,625
[ -0.1445422, -0.149825, -0.09127825, 0.3103561, -0.09490747, 0.08690339, -0.2359289, 0.09235143, -0.1222831, 0.2015831, 0.1503187, 0.2375374, 0.4230411, 0.115284, -0.1702652, -0.08853177, -0.6097656, 0.1060295, -0.03230744, -0.2029195, 0.07987576, 0.2081128, 0.07378669, ...
Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.
The non-essential amino acid, glutamine, exerts pleiotropic effects on cell metabolism, signalling and stress resistance. Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, interleukin-8 (IL-8). Glu...
25,254,627
[ 0.0534256, 0.1824973, 0.02991941, 0.02309888, -0.03498943, -0.2136335, 0.01747153, -0.1820945, -0.02169258, 0.226561, -0.3108461, -0.1254889, -0.1074459, 0.2053979, -0.08709439, 0.05032817, -0.3081405, 0.2462315, -0.1166852, 0.02242483, -0.06895018, 0.0712818, 0.02021135,...
Intra- and inter-pandemic variations of antiviral, antibiotics and decongestants in wastewater treatment plants and receiving rivers.
The concentration of eleven antibiotics (trimethoprim, oxytetracycline, ciprofloxacin, azithromycin, cefotaxime, doxycycline, sulfamethoxazole, erythromycin, clarithromycin, ofloxacin, norfloxacin), three decongestants (naphazoline, oxymetazoline, xylometazoline) and the antiviral drug oseltamivir's active metabolite, ...
25,254,643
[ -0.1457033, 0.1276916, -0.1875429, -0.1836244, -0.2892832, -0.3166263, -0.05069225, 0.04806164, 0.03378164, -0.1560794, 0.142079, -0.3091719, 0.2903137, 0.298454, -0.2140547, -0.1224232, 0.05483087, 0.2664909, 0.04416975, 0.1646657, -0.1517807, 0.1210531, 0.003710103, -...
The comparative photodegradation activities of pentachlorophenol (PCP) and polychlorinated biphenyls (PCBs) using UV alone and TiO2-derived photocatalysts in methanol soil washing solution.
Photochemical treatment is increasingly being applied to remedy environmental problems. TiO2-derived catalysts are efficiently and widely used in photodegradation applications. The efficiency of various photochemical treatments, namely, the use of UV irradiation without catalyst or with TiO2/graphene-TiO2 photodegradat...
25,254,664
[ -0.06348151, 0.2596121, -0.1939557, -0.2462577, -0.004293968, -0.04107016, -0.2603942, -0.01434615, -0.1279975, 0.2425475, -0.06246521, -0.1765673, -0.2019189, 0.2254221, -0.1367683, 0.0994192, -0.6293565, 0.3247734, -0.1344702, 0.1786037, 0.0698478, 0.2386337, -0.134061,...
Maximal strength, muscular endurance and inflammatory biomarkers in young adult men.
The aim was to study associations of maximal strength and muscular endurance with inflammatory biomarkers independent of cardiorespiratory fitness in those with and without abdominal obesity. 686 young healthy men participated (25±5 years). Maximal strength was measured via isometric testing using dynamo-meters to dete...
25,254,894
[ -0.06943628, 0.1404428, -0.04294637, -0.05390272, 0.1842831, -0.4720998, -0.5167893, -0.01761159, -0.2202955, -0.217692, 0.1320898, -0.1083044, 0.01857325, 0.03973254, -0.5003858, -0.09937264, -0.507742, -0.2415368, -0.1147018, -0.1025125, -0.382691, -0.2248196, -0.26997,...
A method of analysis for T-2 toxin and neosolaniol by UPLC-MS/MS in apple fruit inoculated with Trichothecium roseum.
Trichothecenes are one of the most important groups of mycotoxins produced by Trichothecium roseum, which causes core rot of apple. A reliable and sensitive method was developed and successfully applied for the rapid detection of trichothecenes including T-2 toxin and neosolaniol in harvested apple using UPLC-MS/MS. Af...
25,254,921
[ 0.02727395, 0.1860279, -0.3719199, -0.3526417, -0.1807269, -0.09129019, -0.2211946, 0.2236415, 0.135817, 0.2623825, 0.1616039, 0.2998186, -0.04823951, -0.1252726, -0.5389186, -0.1993275, -0.1885748, 0.2314057, 0.1512542, -0.01344283, 0.07175884, 0.2595012, -0.2392719, -...
Strengthening global health security by developing capacities to deploy medical countermeasures internationally.
In 2014, the United States in partnership with international organizations and nearly 30 partner countries launched the Global Health Security Agenda (GHSA) to accelerate progress to improve prevention, detection, and response capabilities for infectious disease outbreaks that can cause public health emergencies. Objec...
25,254,917
[ -0.2408743, -0.1636241, 0.1663785, -0.4137531, 0.1627127, -0.1572464, -0.1912516, -0.2047212, 0.03699329, 0.04235872, 0.09396286, -0.1840364, -0.1009543, 0.0692164, -0.2089034, -0.1916306, 0.03084082, -0.04189383, -0.09410326, -0.1893895, 0.2073227, -0.04175751, -0.330514...
Mixtec Mexican Amerindians: an HLA alleles study for America peopling, pharmacogenomics and transplantation.
HLA-A, -B and -DRB1 alleles have been studied in a Mixtec Mexican Amerindian population by indirect DNA sequencing. HLA relatedness has been tested by comparing results with other Amerindians and worldwide populations; a total of 15,681 chromosomes have been used. Genetic distances between populations, Neighbour Joinin...
25,254,939
[ 0.1631542, -0.1310308, 0.6574928, 0.02184243, 0.2510762, -0.2072933, -0.1918595, 0.1872124, 0.3039559, -0.1539964, 0.06813031, 0.07354384, 0.115571, -0.05093551, -0.05933677, -0.001651466, 0.15417, 0.1626465, 0.1027586, 0.08201967, 0.444306, 0.2418655, -0.1208467, 0.109...
Adsorption of zwitterionic surfactant on limestone measured with high-performance liquid chromatography: micelle-vesicle influence.
Herein is presented a new methodology to determine the static adsorption of a zwitterionic surfactant on limestone in three different aqueous media [high-performance liquid chromatography (HPLC) water, seawater, and connate water] with the use of HPLC at room temperature and 70 °C. The results showed that, in both HPLC...
25,254,947
[ -0.5578105, 0.1888337, 0.1504993, -0.2136683, -0.2091455, 0.0743973, -0.2573332, -0.1455617, 0.1329426, 0.1479119, -0.07293016, 0.5422816, -0.1090329, -0.1881107, -0.4212134, -0.2595619, -0.6869568, 0.1399153, 0.3232629, 0.3290799, 0.4808781, -0.1951663, -0.03174194, 0....
Low-temperature solution growth of ZnO nanocone/highly oriented nanorod arrays on copper.
Solution-phase approaches to one-dimensional (1D) ZnO nanostructure arrays are appealing because of their good potential for scale-up. Allowing for a wide variety of substrate material compatibility and saving energy, it is very essential to further research the low-temperature growth process of 1D ZnO nanostructure ar...
25,254,950
[ -0.2394061, 0.01742163, 0.1354513, 0.1328479, 0.06531731, -0.05729819, -0.567864, -0.262532, 0.1709358, 0.03585904, -0.01041378, -0.2367148, -0.1211099, -0.03020237, -0.4216107, -0.2857901, 0.005588567, 0.1971831, -0.3309239, 0.09289198, 0.3630834, 0.06779153, -0.00290817...
Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle.
Cancer cachexia is a syndrome of weight loss that results from the selective depletion of skeletal muscle mass and contributes significantly to cancer morbidity and mortality. The driver of skeletal muscle atrophy in cancer cachexia is systemic inflammation arising from both the cancer and cancer treatment. While the i...
25,254,959
[ 0.2539206, -0.1458554, 0.04396847, -0.4310827, 0.05902028, 0.01554176, 0.1517621, 0.0651165, 0.03003046, 0.01496276, 0.03849041, -0.008787009, -0.01304132, 0.005298777, -0.1640106, -0.02598244, -0.3820841, 0.001882164, 0.01454654, 0.1848199, 0.06490282, 0.02745754, -0.067...
Pd-catalyzed α-arylation of trimethylsilyl enolates of α,α-difluoroacetamides.
We report the arylation and heteroarylation of α,α-difluoro-α-(trimethylsilyl)acetamides with aryl and heteroaryl bromides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)2Cy as ligand. A broad range of electronically varied aryl and heteroaryl bromides underwent this transformation to ...
25,254,966
[ -0.1811923, -0.05710483, 0.06647592, 0.06717533, 0.2929291, 0.01262162, -0.4678196, 0.3447427, 0.09367295, 0.2096719, -0.1293939, -0.03979312, 0.1834924, -0.05175149, -0.4332837, -0.2160183, -0.4709468, 0.1580822, -0.03941633, 0.3802586, -0.1388138, 0.07235386, -0.3432048...
Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.
In the negative feedback loop comprising the Neurospora circadian oscillator, the White Collar Complex (WCC) formed from White Collar-1 (WC-1) and White Collar-2 (WC-2) drives transcription of the circadian pacemaker gene frequency (frq). Although FRQ-dependent repression of WCC has been extensively studied, the mechan...
25,254,987
[ 0.07986203, 0.01486799, -0.253031, -0.2213033, -0.1783836, -0.1099201, 0.1305635, 0.161113, 0.3099572, 0.0301333, 0.1830596, 0.1754475, -0.09334729, 0.05382472, -0.3567676, 0.00287475, -0.2461157, -0.1798182, 0.007525535, -0.5343894, 0.1373199, 0.05897325, -0.2250662, -...
Putting it all together: recommendations for improving pain management in plastic surgical procedures-surgical facial rejuvenation.
Postoperative pain is a major concern for patients undergoing facial aesthetic surgery. Aggressive efforts to reduce postoperative pain while avoiding adverse sequelae, such as nausea and vomiting, will result in an improved patient experience. Newer pharmaceuticals, medical devices, and longer-acting local anesthetics...
25,254,992
[ 0.2127695, 0.1896219, -0.2862774, -0.4697634, -0.03473001, -0.3105514, -0.03862734, -0.2110938, 0.1742824, -0.293418, 0.2559235, -0.2847654, 0.01449873, -0.2079411, -0.2565651, -0.04392165, -0.2176151, -0.1500019, 0.3697832, 0.01438891, -0.1826663, -0.0257835, -0.2350655,...
Cardiac evaluation and management before vascular surgery.
The most common and significant morbidity and mortality of vascular surgical procedures remain coronary artery disease, arrhythmia, and heart failure. Cardiac evaluation and medical optimization provide the groundwork for best medical practice in an otherwise high-risk surgical population. The goal of this study is to ...
25,255,034
[ -0.05457417, 0.1278162, -0.3972934, -0.4219158, -0.03581904, -0.3089028, 0.008099303, -0.002435425, 0.1286242, -0.3351436, 0.06662706, 0.1269041, -0.07490754, -0.582465, -0.08311316, 0.1514414, -0.5565036, 0.1696362, 0.2149174, 0.0729631, -0.3231094, 0.2719533, -0.1397132...
Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis of Fusarium verticillioides and maize kernels.
Fusarium verticillioides is one of the most important fungal pathogens causing ear and stalk rot in maize, even if frequently asymptomatic, producing a harmful series of compounds named fumonisins. Plant and fungal oxylipins play a crucial role in determining the outcome of the interaction between the pathogen and its ...
25,255,035
[ 0.0003534951, 0.07188287, 0.1976009, -0.170735, 0.05982361, -0.1133172, 0.06821743, 0.08641052, 0.1016835, -0.2051637, 0.2326263, 0.03844226, 0.06672452, -0.1852476, -0.3693834, 0.08656456, -0.6953016, 0.06634464, 0.02918485, 0.01570552, 0.1384925, 0.05799266, -0.231227, ...
Capture of heliophobic atoms by (4)He nanodroplets: the case of cesium.
Within Density Functional Theory (DFT), we address the capture of a Cs atom by a superfluid helium nanodroplet using models of different complexity. In the simplest model, the Cs-droplet potential is obtained in two extreme approximations, namely the sudden approximation in which one assumes that the density of the dro...
25,255,044
[ -0.3131259, 0.1495344, -0.06109738, 0.227444, 0.07638468, -0.3198531, -0.5374255, -0.2207317, 0.194901, 0.1962823, -0.1452308, 0.0276602, -0.1696001, 0.05303779, -0.6337967, -0.1367912, -0.2594473, 0.03368618, -0.07805927, -0.03957428, 0.160684, 0.1398677, 0.1286933, -0...
Hypothalamic S1P/S1PR1 axis controls energy homeostasis.
Sphingosine 1-phosphate receptor 1 (S1PR1) is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) that has a role in many physiological and pathophysiological processes. Here we show that the S1P/S1PR1 signalling pathway in hypothalamic neurons regulates energy homeostasis in rodents. We demonstrate that S1P...
25,255,053
[ 0.1572752, -0.2606613, -0.1903095, -0.391621, 0.1964696, -0.3341282, -0.09729871, 0.01800014, -0.1536679, -0.2311157, 0.1180523, 0.2233944, -0.1785296, -0.2812287, -0.2797929, -0.03512152, -0.1550902, -0.06315244, -0.005532705, -0.02258971, 0.007880001, 0.2830261, -0.0564...
Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis.
Venous thrombosis (VT) is a significant cause of morbidity and mortality in humans. Surgical animal models are crucial in studies investigating the pathogenesis of this disease and evaluating VT therapies. Because inflammation is critical to both the development and resolution of VT, analgesic medications have the pote...
25,255,071
[ 0.3005482, 0.07020296, -0.3326962, -0.5377588, 0.1937345, -0.295403, 0.2300736, -0.04031717, -0.2822832, -0.3557918, -0.1212658, -0.0649345, -0.1301194, 0.03938894, -0.2042123, -0.09804492, -0.0651162, 0.115315, 0.3874543, 0.5978184, -0.1955862, 0.1928984, -0.2879167, -...
A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging.
A lysosome-targeted fluorescent chemodosimeter, 1, was developed for monitoring endogenous and exogenous H2S by in vivo imaging of HeLa cells, D. melanogaster and C. elegans. In the tests of mutated C. elegans (SRP-6 nulls), chemodosimeter 1 could trace the accumulation of lysosome and lysosomal injury with a high reso...
25,255,077
[ 0.03808244, -0.02809728, -0.08234593, 0.3260997, -0.2339074, 0.07618079, -0.04254586, -0.08674264, 0.1233519, -0.1085833, 0.1604714, 0.5212658, -0.05272746, -0.3146808, 0.1034634, 0.2680509, -0.5576755, 0.1778145, 0.3190562, -0.2492122, 0.3111861, 0.1636631, -0.09293026, ...
Gastroesophageal reflux disease and risk for bipolar disorder: a nationwide population-based study.
Studies have shown that chronic inflammation may play a vital role in the pathophysiology of both gastroesophageal reflux disease (GERD) and bipolar disorder. Among patients with GERD, the risk of bipolar disorder has not been well characterized. We explored the relationship between GERD and the subsequent development ...
25,255,080
[ -0.04830369, -0.2649746, -0.3472657, 0.3048155, 0.156139, -0.03288987, -0.1274897, 0.09284237, -0.2407634, -0.03292795, -0.04959135, 0.09230757, 0.001944966, 0.01134554, 0.1361558, 0.1123597, -0.286994, 0.6645229, 0.03112149, -0.2994457, 0.03976594, 0.01664877, -0.4364566...
A widely used in vitro biofilm assay has questionable clinical significance for enterococcal endocarditis.
Biofilm formation may play an important role in the pathogenesis of infections caused by Enterococcus faecalis, including endocarditis. Most biofilm studies use a polystyrene dish assay to quantify biofilm biomass. However, recent studies of E. faecalis strains in tissue and animal models suggest that polystyrene dish ...
25,255,085
[ -0.1278531, 0.05589874, -0.3666281, 0.06253872, -0.09545144, -0.2077777, 0.1454486, 0.3152549, -0.1884218, -0.1431707, 0.1059814, 0.1714781, 0.04337377, -0.1459437, -0.1470337, -0.07643936, -0.5783716, 0.2640498, -0.1807823, 0.2816165, 0.3054725, 0.2628999, 0.004866884, ...
Nipbl and mediator cooperatively regulate gene expression to control limb development.
Haploinsufficiency for Nipbl, a cohesin loading protein, causes Cornelia de Lange Syndrome (CdLS), the most common "cohesinopathy". It has been proposed that the effects of Nipbl-haploinsufficiency result from disruption of long-range communication between DNA elements. Here we use zebrafish and mouse models of CdLS to...
25,255,084
[ 0.07194383, 0.3228542, 0.00480093, -0.3018881, -0.01512682, -0.02352511, -0.007625796, 0.03699983, 0.2728544, 0.4241599, -0.2132179, 0.1301081, -0.1415918, -0.2687077, -0.3432592, 0.3860647, -0.2006125, -0.1986989, -0.1905597, 0.1311794, 0.6092862, -0.06785526, 0.1170673,...
Gamma delta T cells recognize haptens and mount a hapten-specific response.
The ability to recognize small organic molecules and chemical modifications of host molecules is an essential capability of the adaptive immune system, which until now was thought to be mediated mainly by B cell antigen receptors. Here we report that small molecules, such as cyanine 3 (Cy3), a synthetic fluorescent mol...
25,255,099
[ -0.102417, -0.06854422, -0.350385, 0.06886675, 0.1285212, -0.3214265, -0.17139, 0.4879535, 0.2233844, 0.1617921, 0.03614004, 0.157487, 0.3555325, 0.06819319, -0.6405196, -0.3238127, -0.5414402, 0.284852, 0.0587516, 0.24975, 0.05732032, 0.1779272, -0.2067883, -0.2532152,...
Where the road ends, yaws begins? The cost-effectiveness of eradication versus more roads.
A disabling and disfiguring disease that "begins where the road ends", yaws is targeted by WHO for eradication by the year 2020. The global campaign is not yet financed. To evaluate yaws eradication within the context of the post-2015 development agenda, we perform a somewhat allegorical cost-effectiveness analysis of ...
25,255,131
[ -0.1140979, -0.04325831, -0.09174186, -0.1538724, 0.1741522, -0.1463238, -0.01469342, 0.1339706, 0.2260339, -0.1817973, -0.1865827, -0.2590935, 0.05060587, 0.05291877, -0.366991, -0.01811797, -0.2203515, -0.1120168, -0.1172621, -0.09381614, 0.07929762, 0.54147, -0.1128601...
Efficacy and safety of systemic tacrolimus in high-risk penetrating keratoplasty after graft failure with systemic cyclosporine.
The aim of this study was to investigate the efficacy and safety of systemic tacrolimus for the treatment of eyes that developed graft failure despite treatment with cyclosporine (CsA). Ten eyes of 10 patients who underwent high-risk penetrating keratoplasty (PKP) and developed graft failure despite treatment with syst...
25,255,133
[ 0.1275229, -0.1461326, -0.2275176, -0.3692057, 0.1715838, -0.2202658, -0.01407904, 0.4710395, -0.1187274, -0.5484604, 0.2639775, -0.6455985, -0.0883084, 0.2906686, 0.0688896, -0.2924233, -0.6998444, 0.1405082, 0.1959972, 0.04660697, -0.1113751, 0.5563604, -0.218959, 0.2...
Instrument development of the UNC Dry Eye Management Scale.
Dry eye disease (DED) is a common ocular disease that can have adverse effects on quality of life. Our aim was to develop a single-item questionnaire that is reliable, patient-driven, and clinic friendly to assess DED symptoms and their effect on quality of life to help support the management of patients with DED. An i...
25,255,135
[ -0.27428, -0.1753686, 0.3388236, 0.0708665, 0.02313273, -0.2369892, -0.1329449, 0.2267791, 0.09797034, -0.1423527, 0.2066647, 0.1555595, -0.06119974, -0.2364122, -0.04282911, -0.1570159, -0.583844, 0.0887027, 0.00859185, 0.01780934, -0.1123492, 0.2135629, -0.1667227, 0....
Extraorbital lacrimal gland excision: a reproducible model of severe aqueous tear-deficient dry eye disease.
The aim of this study was to establish and characterize extraorbital lacrimal gland excision (LGE) as a model of aqueous tear-deficient dry eye disease in mice. Female C57BL/6 mice at 6 to 8 weeks of age were randomized to extraorbital LGE, sham surgery, or scopolamine groups. Mice that underwent extraorbital LGE or sh...
25,255,136
[ -0.004970712, -0.5897887, -0.500417, -0.2150361, -0.3113877, -0.4612742, 0.270322, -0.06372755, 0.1515559, -0.06002424, 0.005295103, 0.3670283, 0.09883992, -0.09800074, -0.5495049, 0.1402696, -0.1049972, 0.05390682, -0.1251348, 0.2265977, -0.06877866, -0.004920923, 0.0606...
Chemical fingerprint and metabolic profile analysis of Citrus reticulate 'Chachi' decoction by HPLC-PDA-IT-MS(n) and HPLC-Quadrupole-Orbitrap-MS method.
A method incorporating HPLC-PDA-IT-MS(n) with HPLC-Quadrupole-Orbitrap-MS was developed for the investigation of chemical fingerprint of Citrus reticulate 'Chachi' decoction (CRCD) and metabolic profile of SD rat plasma sample after oral administration of CRCD (1.5 g herb/kg). A total of 27 chemical constituents of CRC...
25,255,155
[ -0.07667659, 0.2742949, -0.1091972, 0.1383564, 0.2208595, -0.02947209, 0.1214314, 0.0862167, 0.3361727, 0.04028517, 0.05562339, 0.2378482, 0.06444518, -0.1257926, -0.4401972, 0.06293337, -0.7060407, 0.09044269, 0.3269613, 0.2070923, 0.1149613, 0.2983251, -0.09054197, -0...
Constipation after thoraco-lumbar fusion surgery.
Thoraco-lumbar posterior fusion surgery is a frequent procedure used for patients with spinal instability due to tumor, trauma or degenerative disease. In the perioperative phase, many patients may experience vomiting, bowel irritation, constipation, or may even show symptoms of adynamic ileus possibly due to immobiliz...
25,255,157
[ -0.01450391, 0.002421231, 0.01661081, -0.128324, -0.376029, -0.5096185, 0.0686786, -0.1823766, -0.193558, -0.4586576, -0.3010558, -0.08053332, -0.01223646, -0.2266181, -0.07331825, -0.04303987, -0.6584879, 0.173805, 0.02739985, 0.08376908, -0.07642588, 0.1526088, -0.25893...
Comparison of echocardiographic measurements in elite and nonelite Arabian endurance horses.
To determine whether echocardiographic variables differed between successful (elite) and less successful (nonelite) Arabian endurance horses. 34 Arabian horses that competed in endurance racing. Horses were assigned to either an elite or nonelite group on the basis of results of a previous competition, and a standardiz...
25,255,178
[ -0.4292506, 0.3245254, -0.06719839, -0.1874084, -0.05882593, -0.6659655, -0.1623662, -0.4304432, -0.1455953, -0.2311839, -0.01676504, 0.2157522, -0.1365055, -0.03323836, -0.2209325, 0.05944279, -0.4646715, 0.2884826, 0.09091058, -0.3899066, -0.2201349, 0.01368659, -0.0712...
Expression of epidermal growth factor receptor and human epidermal growth factor receptor 2 in periocular squamous cell carcinomas of horses.
To determine whether epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) are expressed in periocular squamous cell carcinomas (SCCs) of horses. Biopsy specimens of SCCs from 46 horses. Pathology records were searched retrospectively for biopsy specimens of periocular SCCs obtaine...
25,255,181
[ 0.03610846, -0.2262612, -0.1080127, -0.08590969, -0.05576086, -0.08231514, 0.1754077, 0.02985719, 0.09171396, 0.0478426, -0.02492952, 0.03739844, -0.07696296, 0.1019692, 0.1527112, -0.09201805, -0.175351, 0.4932146, 0.02614288, 0.03124179, 0.200017, 0.1780815, 0.008843232...
Highly-efficient enzymatic conversion of crude algal oils into biodiesel.
Energy-intensive chemical conversion of crude algal oils into biodiesel is a major barrier for cost-effective algal biofuel production. To overcome this problem, we developed an enzyme-based platform for conversion of crude algal oils into fatty acid methyl esters. Crude algal oils were extracted from the oleaginous mi...
25,255,191
[ -0.1460158, -0.009683117, -0.20325, -0.1045051, -0.1021177, -0.1858379, -0.3000512, 0.4063281, 0.2750097, 0.1829368, 0.0264592, -0.4247757, -0.2916165, 0.2411747, -0.1723305, 0.3261404, -0.5869431, 0.2312668, 0.02828313, 0.4375322, 0.3990594, 0.4610275, -0.1404322, 0.04...
Tracing the origin of suspended sediment in a large Mediterranean river by combining continuous river monitoring and measurement of artificial and natural radionuclides.
Delivery of suspended sediment from large rivers to marine environments has important environmental impacts on coastal zones. In France, the Rhone River (catchment area of 98,000 km(2)) is by far the main supplier of sediment to the Mediterranean Sea and its annual solid discharge is largely controlled by flood events....
25,255,199
[ 0.01789961, 0.1632455, 0.0576815, -0.0298355, 0.009968335, -0.3371762, -0.237517, 0.0008008172, 0.193347, 0.3627999, -0.12434, 0.009889817, -0.1144348, 0.04661188, -0.3477742, -0.01770835, -0.3209155, 0.2078986, 0.163238, 0.3077745, 0.2882546, 0.01520263, -0.1727644, 0....
A distinct tethering step is vital for vacuole membrane fusion.
Past experiments with reconstituted proteoliposomes, employing assays that infer membrane fusion from fluorescent lipid dequenching, have suggested that vacuolar SNAREs alone suffice to catalyze membrane fusion in vitro. While we could replicate these results, we detected very little fusion with the more rigorous assay...
25,255,215
[ 0.05891692, -0.1905677, -0.2924095, -0.1685887, 0.1269745, -0.1867487, 0.09899522, 0.1735361, -0.07994457, -0.01415169, -0.02837111, -0.2504454, -0.1903307, -0.2057628, -0.6381653, 0.07343869, -0.6048099, 0.04260373, 0.2397877, -0.03418016, 0.4306913, 0.3723587, -0.077716...
Quantifying the impact and extent of undocumented biomedical synonymy.
Synonymous relationships among biomedical terms are extensively annotated within specialized terminologies, implying that synonymy is important for practical computational applications within this field. It remains unclear, however, whether text mining actually benefits from documented synonymy and whether existing bio...
25,255,227
[ 0.02520257, 0.249983, 0.1294336, 0.3722925, 0.1431069, 0.02628322, 0.144047, 0.2585504, 0.1572159, -0.1981714, -0.2621675, -0.2356147, 0.1101471, -0.2028288, -0.4846704, 0.1041072, -0.2479462, -0.0544427, 0.1714195, -0.08943613, 0.1618365, 0.4414788, 0.04004124, 0.23795...
Choosing Wisely: a neurosurgical perspective on neuroimaging for headaches.
Multiple national initiatives seek to curb spending to address increasing healthcare costs in the United States. The Choosing Wisely initiative is a popular initiative that focuses on reducing healthcare spending by setting guidelines to limit tests and procedures requested by patients and ordered by physicians. To red...
25,255,253
[ -0.2330767, 0.2601246, 0.01395017, -0.3942287, 0.227694, -0.02139003, -0.1996656, -0.09655831, -0.04552178, -0.08048914, 0.115597, 0.3105189, -0.2999038, -0.242923, -0.3678678, 0.04284516, -0.2622014, 0.3777023, -0.004230157, 0.05020364, -0.08238699, 0.02388874, 0.0111078...
Domestic harm and neglect among lesbian, gay, and bisexual older adults.
This study examined harm, hurt, and neglect by caregivers as well as self-neglect and physical and mental health status among 113 lesbian, gay, and bisexual (LGB) older adults aged 60-88 years, who attended community-based social and recreation programs or groups in the United States. Reporting on their experiences wit...
25,255,273
[ -0.3232811, 0.38198, -0.3234153, -0.05377176, -0.01495464, -0.09395527, -0.3748105, -0.3737701, -0.1610545, -0.2979646, 0.1501396, -0.0829214, -0.407565, -0.01489451, 0.3010185, 0.1420095, -0.33102, 0.3547986, 0.3548967, -0.2819109, -0.07459477, 0.5424395, 0.07414401, -...
Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.
Two structurally distinct series of novel, MAPK-activated kinase-2 prevention of activation inhibitors have been discovered by high throughput screening. Preliminary structure-activity relationship (SAR) studies revealed substructural features that influence the selective inhibition of the activation by p38α of the dow...
25,255,283
[ 0.04156566, -0.06070212, 0.01866388, -0.1268155, -0.04872333, 0.1899925, -0.03693498, 0.2032705, 0.2105781, -0.2711475, 0.02819385, -0.2886832, 0.309779, 0.1123025, -0.4006132, 0.0918119, -0.4052191, -0.07013115, -0.1392499, 0.167867, 0.09128348, -0.005339342, -0.2128073,...
Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.
To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured ...
25,255,292
[ -0.000175457, 0.07135567, -0.03012187, -0.144315, 0.1797349, -0.5585181, -0.3236731, 0.1120961, 0.0222893, -0.03945524, 0.1416124, 0.6033563, -0.1098901, 0.02360972, -0.1233553, 0.2635744, -0.2619203, 0.1908357, 0.131013, 0.5586618, -0.09932189, 0.3379412, -0.106419, -0...
Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer.
A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsatellite instability (...
25,255,306
[ 0.1152642, 0.05376769, -0.03851385, -0.2007036, -0.3009456, -0.1207307, 0.0632908, 0.2427842, 0.2686552, 0.04840096, 0.2021311, 0.3868271, -0.001588705, 0.03420944, -0.1913156, -0.1373752, -0.009920179, 0.0354181, 0.09871598, -0.07489543, 0.187561, 0.06559876, -0.09605715...
Hybrid and rogue kinases encoded in the genomes of model eukaryotes.
The highly modular nature of protein kinases generates diverse functional roles mediated by evolutionary events such as domain recombination, insertion and deletion of domains. Usually domain architecture of a kinase is related to the subfamily to which the kinase catalytic domain belongs. However outlier kinases with ...
25,255,313
[ 0.2055476, -0.1290888, 0.2250097, -0.2843411, 0.1724096, -0.3521424, 0.3410486, 0.1203368, 0.1885439, 0.05474823, 0.2066448, -0.200992, -0.0101174, 0.1182283, -0.4140227, 0.03686192, -0.2999741, -0.02595542, 0.2944585, -0.2470499, 0.1810479, 0.0794544, 0.1311581, 0.1880...
Distinct contributions of adverse childhood experiences and resilience resources: a cohort analysis of adult physical and mental health.
Although evidence is rapidly amassing as to the damaging potential of early life adversities on physical and mental health, as yet few investigations provide comparative snapshots of these patterns across adulthood. This population-based study addresses this gap, examining the relationship of adverse childhood experien...
25,255,340
[ -0.2218584, -0.0003539911, -0.2099202, 0.01643474, -0.07999066, -0.2106146, -0.3193553, -0.06201225, -0.02565143, 0.0953942, 0.05514222, -0.08672013, -0.2885936, -0.138292, 0.08582415, 0.1016128, -0.1415129, 0.2997475, 0.2594954, -0.08619618, -0.2614288, 0.08292625, -0.06...
Coagulation phenotypes in septic shock as evaluated by calibrated automated thrombography.
Sepsis induces alterations of coagulation suggesting both hypercoagulable or hypocoagulable features. The result of their combination remains unknown, making it difficult to predict whether one prevails over the other. Thrombin generation tests (TGTs) stand as an interesting tool to establish an integrative phenotype o...
25,255,379
[ 0.240521, 0.4101725, 0.003431028, -0.239217, -0.1327568, -0.06711232, 0.06737368, 0.1303624, 0.1074574, -0.005799494, -0.132669, 0.05581088, -0.1697296, -0.05830979, -0.2196669, -0.1717419, -0.1555675, 0.09187189, 0.1547724, 0.07330102, 0.1811029, 0.1227566, -0.1549309, ...
Potential cost-effectiveness of therapeutic drug monitoring in patients with resistant hypertension.
Nonadherence to drug therapy poses a significant problem in the treatment of patients with presumed resistant hypertension. It has been shown that therapeutic drug monitoring (TDM) is a useful tool for detecting nonadherence and identifying barriers to treatment adherence, leading to effective blood pressure (BP) contr...
25,255,395
[ -0.09735991, 0.07386111, -0.1441454, 0.07808338, -0.03872164, -0.2264777, 0.06522576, -0.007239261, 0.1212578, -0.3452026, -0.03235554, 0.2560433, -0.285866, 0.02205772, -0.3539379, -0.1583785, -0.3832969, 0.2723929, -0.2920575, 0.007236265, 0.02341923, 0.03922509, -0.229...
Outcome of regional lymphadenectomy in accordance with primary tumor location on laparoscopic nephroureterectomy for urothelial carcinoma of the upper urinary tract: a prospective study.
To determine the appropriate template of regional lymph node dissection (LND) at the time of laparoscopic nephroureterectomy (LNU) for patients with clinically node- negative urothelial carcinoma of the upper urinary tract. This prospective study included 45 patients undergoing LND with LNU in accordance with our prosp...
25,255,401
[ 0.15337, -0.1185857, -0.3433587, -0.3456179, -0.04840007, -0.4354487, 0.09640644, -0.003999406, -0.01816708, -0.01327813, 0.05841658, -0.05816497, 0.2180649, -0.2427488, -0.4877178, -0.04018126, 0.07718218, 0.4997408, 0.0308703, 0.095621, 0.2903471, 0.2815596, -0.4792208,...
A cost analysis of the impact of a new intravenous antihypertensive in managing perioperative blood pressure during cardiac surgery.
To examine the impact of intravenous antihypertensive selection on hospital health resource utilization using data from the Evaluation of CLevidipine In the Perioperative Treatment of Hypertension Assessing Safety Events (ECLIPSE) trials. Analysis of ECLIPSE trial data comparing clevidipine to nitroglycerin, sodium nit...
25,255,404
[ -0.2240997, 0.007940522, -0.5695658, 0.01837122, 0.04522, -0.331977, -0.05395182, -0.1193278, 0.2156408, 0.1500805, 0.03199584, 0.3474177, 0.07599159, -0.1606361, -0.08596893, -0.01908739, -0.4604541, -0.03107973, -0.1085283, -0.1618656, 0.02098144, 0.1894476, 0.09074577,...
Management of hemorrhage with the target-specific oral anticoagulants.
The target-specific oral anticoagulants have recently been introduced as alternatives to warfarin for both prophylactic and therapeutic indications. Although their efficacy and side-effect profiles have been favorable, there is significant concern about management of hemorrhage with these agents as there is no direct r...
25,255,409
[ -0.2602369, 0.329294, -0.1508315, -0.1162511, 0.123246, -0.0227156, -0.02619099, 0.02731497, 0.03063507, -0.08049971, -0.02648362, 0.5582741, 0.07163784, -0.2371855, -0.4229421, -0.05355292, -0.3151921, -0.06353899, 0.2395847, -0.3058822, -0.0824641, 0.2628356, -0.2495417...
The likelihood of achieving quantified road safety targets: a binary logistic regression model for possible factors.
In past several decades, many countries have set quantified road safety targets to motivate transport authorities to develop systematic road safety strategies and measures and facilitate the achievement of continuous road safety improvement. Studies have been conducted to evaluate the association between the setting of...
25,255,417
[ -0.04638899, 0.05585535, 0.01217153, 0.2982241, 0.06441271, -0.09403671, -0.2169852, -0.1015437, -0.01166921, -0.2081492, -0.1503772, -0.3957405, 0.08196147, 0.267411, 0.02463433, -0.03092948, -0.5898305, -0.005857883, 0.12888, -0.06150078, 0.134091, 0.2713215, -0.0438058...
Investigation of various types of inverse micelles in nonpolar liquids using transient current measurements.
Transient current measurements are used to characterize a wide variety of charge carriers in nonpolar liquids. The transient current method allows us to obtain both the concentration and mobility of charge carriers and therefore also the hydrodynamic radius using Stokes' law. In this article, five different surfactants...
25,255,418
[ -0.09843818, -0.09109599, 0.07555684, -0.316682, -0.00101238, -0.1029103, -0.183782, -0.2351424, 0.2792761, 0.1679962, -0.2159417, -0.1190564, 0.2130882, 0.06727517, -0.2840896, -0.08859854, -0.5848296, 0.1970791, -0.0490567, -0.1683015, 0.1572476, 0.0106569, 0.2542799, ...
First step into space: performance and morphological evolution of P3HT:PCBM bulk heterojunction solar cells [corrected] under AM0 illumination.
P3HT (poly(3-hexylthiophene-2,5-diyl)):PC61BM ([6,6]-phenyl-C61 butyric acid methyl ester) bulk heterojunction solar cells are fabricated and characterized as a function of solar intensity, temperature, and aging at vacuum conditions under illumination with AM0 illumination for testing potential use in space applicatio...
25,255,423
[ -0.3177931, -0.2726988, 0.03365959, -0.107549, -0.04543734, -0.07703007, -0.1263571, 0.2319946, 0.01485238, 0.04593951, -0.1990123, -0.2377872, 0.156842, -0.2152477, -0.4259053, 0.01466007, -0.03251559, 0.694649, 0.001751496, 0.4595574, 0.4560949, 0.4567441, -0.07611753, ...
Single-dose etomidate does not increase mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials and observational studies.
The effect of single-dose etomidate on mortality in patients with sepsis remains controversial. We systematically reviewed the literature to investigate whether a single dose of etomidate for rapid sequence intubation increased mortality in patients with sepsis. PubMed, Embase, and CENTRAL (Cochrane Central Register of...
25,255,427
[ -0.0281072, -0.1384639, -0.1847487, -0.1908506, 0.06125374, -0.04600926, -0.01816966, -0.2036437, -0.2944132, -0.1762652, -0.06255914, 0.3949049, 0.1775663, 0.2982178, 0.06735581, -0.2447843, -0.5033194, 0.09794594, -0.2187009, -0.006012369, -0.1889573, -0.06471827, -0.04...
Geographical variation in health-related physical fitness and body composition among Chilean 8th graders: a nationally representative cross-sectional study.
In addition to excess adiposity, low cardiorespiratory fitness (CRF) and low musculoskeletal fitness (MSF) are important independent risk factors for future cardio-metabolic disease in adolescents, yet global fitness surveillance in adolescents is poor. The objective of this study was to describe and investigate geogra...
25,255,442
[ -0.07203346, -0.08802974, 0.1700016, 0.01340699, -0.2249054, 0.02207214, -0.1410713, 0.07323158, -0.2702848, -0.3835481, 0.3353088, -0.3013696, 0.1362222, 0.08661804, -0.5983202, -0.3973525, 0.2106751, 0.09811573, 0.2021778, -0.235875, -0.06508806, 0.247165, -0.2754649, ...
Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-β leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice.
The mechanism of cardiac energy production against sustained pressure overload remains to be elucidated. We generated cardiac-specific kinase-dead (kd) calcium/calmodulin-dependent protein kinase kinase-β (CaMKKβ) transgenic (α-MHC CaMKKβkd TG) mice using α-myosin heavy chain (α-MHC) promoter. Although CaMKKβ activity ...
25,255,457
[ -0.09537774, 0.0899592, -0.1565289, 0.02025045, 0.1457326, 0.01758257, 0.2266006, 0.3139654, 0.2624718, 0.07245219, -0.1787332, 0.3577539, 0.03814534, 0.3154756, -0.5078098, 0.1597258, -0.6274698, -0.04342388, -0.05168401, -0.08023956, 0.211016, 0.1253001, -0.3105551, 0...
Tracheal Epstein-Barr virus-associated smooth muscle tumour in an HIV-positive patient.
Epstein-Barr virus-related smooth muscle tumours (EBV-SMTs) are a rare but well recognized non-AIDS-defining malignancy that can also be found in several other immunosuppressed states. Pulmonary involvement of EBV-SMTs is not uncommon, but it can present with multifocal lesions in any anatomical site. The present artic...
25,255,459
[ -0.1287843, -0.1710957, -0.05154352, -0.257051, 0.003859551, -0.1695576, -0.1912391, -0.1062654, 0.07252588, -0.2487809, 0.3574621, -0.04242079, -0.05793482, -0.1663707, -0.6055163, -0.03700583, -0.4594665, 0.02895318, 0.1032274, -0.2432433, -0.3136745, -0.0154557, -0.194...
Correlation of the interleukin-29 levels in crevicular fluid and plasma with the genetic polymorphism in chronic and aggressive periodontitis patients.
To assess the effect of single nucleotide polymorphism (SNP) on the Interleukin (IL-29) quantity in gingival crevicular fluid (GCF) and plasma of chronic and aggressive periodontitis patients. Patients with periodontal health (n=30), chronic generalized periodontitis (n=30) and generalized aggressive periodontitis (n=3...
25,255,471
[ 0.2028491, -0.1562349, -0.002911824, -0.3252403, -0.1769542, -0.04600852, -0.1060964, 0.1092796, -0.07166662, 0.09457412, 0.07012146, 0.2817817, -0.3250786, 0.1085731, -0.108301, -0.4916789, -0.09147578, 0.008410508, 0.0468428, 0.3728439, -0.02237303, 0.3468013, -0.035821...
Besides fibrillization: putative role of the peptide fragment 71-82 on the structural and assembly behavior of α-synuclein.
The fibrillization of α-synuclein (α-syn) is involved in Parkinson's disease, a neurodegenerative disorder that affects four million people in the world. The amino acid sequence 71-82 of this protein (VTGVTAVAQKTV) has appeared to be essential for fibril formation. In the present study, we have investigated the seconda...
25,255,476
[ -0.3609196, 0.02329455, -0.2901758, -0.4570673, 0.2604823, -0.1409861, 0.1722552, -0.03790865, 0.3861061, 0.05941873, -0.01530324, -0.076024, -0.06777727, -0.4613578, -0.06831375, -0.3472216, -0.5927861, 0.04392553, 0.1565224, 0.1449795, 0.3437779, 0.5981315, -0.2463749, ...
Payment or reimbursement for certain medical expenses for Camp Lejeune family members. Interim final rule.
The Department of Veterans Affairs (VA) is promulgating regulations to implement statutory authority to provide payment or reimbursement for hospital care and medical services provided to certain veterans' family members who resided at Camp Lejeune, North Carolina, for at least 30 days during the period beginning on Ja...
25,255,501
[ -0.4107597, -0.1593515, -0.1546018, 0.1091514, 0.3780215, -0.4634179, -0.3019789, 0.2744932, -0.03799416, 0.1585268, -0.1080527, 0.1701857, -0.09538908, 0.05376144, 0.2277309, -0.2270517, 0.1652321, 0.01566059, -0.318346, -0.189658, 0.1888843, 0.1065266, -0.08607199, 0....
[Determination of eight bisphenol diglycidyl ethers in water by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry].
A solid phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method was developed for the determination of eight bisphenol diglycidyl ethers, including bisphenol A diglycidyl ether (BADGE), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE x HCl), bis...
25,255,565
[ -0.06640127, 0.6023942, -0.09135205, -0.1302509, 0.2916907, -0.06150715, -0.3256373, 0.09405699, -0.04528204, 0.1469219, 0.1325197, 0.2002802, 0.06915848, 0.1089433, -0.3816622, -0.2302173, -0.301425, 0.44192, 0.4533366, 0.06961624, 0.1952054, -0.04738485, -0.1968101, -...
Salmonella bacteraemia among healthcare workers and their dependents.
To determine the incidence and resistance pattern of Salmonella infection in healthcare workers and their dependents. The retrospective analysis was conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, and comprised records of employees and their dependents with bacteraemia from January 200...
25,255,579
[ 0.1862236, -0.670594, -0.07153516, -0.4828738, -0.1508687, -0.3913582, -0.005100273, 0.04002235, -0.3561565, -0.003161031, 0.2654205, 0.1923196, -0.1683363, 0.1624877, -0.1261321, -0.4063783, -0.3983756, 0.2115488, -0.4531448, 0.2093573, -0.07799282, -0.01851301, -0.10365...
Perforation of Meckel's diverticulum by foreign body.
Meckel's diverticulum (MD) is a congenital disorder of the gastrointestinal tract that is usually asymptomatic. Perforation of an MD by foreign bodies is an extremely rare cause of acute abdomen in children. We present a rare case of perforation of an MD in a child after eating melon seeds. The patient was treated succ...
25,255,595
[ -0.5222623, -0.1336702, -0.1781111, -0.1467095, 0.3009852, -0.184992, -0.5531068, -0.1675928, 0.1393262, -0.2053533, 0.4272347, 0.2111427, -0.2968903, -0.02192162, 0.01631207, -0.0496995, -0.6852255, -0.1296874, -0.04196229, -0.3449338, 0.3169521, 0.04386014, -0.2676011, ...
[Drainage pathways of the frontal sinus on oblique multi-planar reconstruction CT scans].
Oblique reconstruction CT images of frontal sinus drainage pathways were created with ONIS which is free DICOM viewer software. By placing the slice line of the cross sectional image on the drainage pathway of the frontal sinus in the sagittal view, the key oblique CT image could be generated in 96.9% of 65 normal para...
25,255,645
[ -0.3704372, 0.1495261, 0.3016539, 0.1003089, 0.1326701, -0.4193362, -0.448457, -0.05231219, -0.2196544, 0.1442382, 0.3422512, -0.3913766, -0.3753999, -0.2336393, -0.3343401, -0.3477855, -0.421524, 0.200514, -0.3309911, -0.127617, 0.05179653, 0.2212358, -0.1914905, 0.085...
[Utilization of ultrasonography in the fields of critical care medicine and anesthesiology: preface and comments ].
Recently, with the development of technology, opportunities for the clinical use of ultrasonography are increasing. Regarding this circumstance, the current issue highlights the use of ultrasonography in critical care and anesthesia Chapters include cardiac, lung and abdominal echography, and various perioperative use ...
25,255,655
[ -0.03784401, -0.1788097, -0.2480374, -0.1357473, 0.3027268, 0.1062994, -0.201365, -0.2602368, -0.06880012, -0.06064622, 0.1031205, -0.2914015, -0.0516241, -0.1137497, -0.3791337, -0.06299698, -0.550465, 0.2992965, -0.0452453, -0.2766004, 0.1727538, 0.005223423, -0.0683206...
[FAST for abdominal trauma].
Japanese Association for Acute Medicine and Japanese Association for The Surgery of Trauma developed JATEC (Japan Advanced Trauma Evaluation and Care) course as an off-the-job training to improve trauma care in Japan. In this course, the trauma patients undergo primary survey and secondary survey. FAST (focused assessm...
25,255,658
[ 0.09892342, -0.02193866, -0.08659737, -0.2632093, 0.07103758, -0.05855318, 0.1491828, -0.1062636, 0.05224264, -0.1910173, 0.1735112, -0.1719311, -0.1380602, 0.08889293, -0.6402309, -0.5303046, -0.3798459, 0.3202496, 0.1471861, -0.4329952, 0.2657591, -0.1806748, -0.211146,...
[Transesophageal and intracardiac echocardiography in therapeutic cardiac catheterizations of structural heart disease].
Recently clinical indication of therapeutic cardiac catheterization (CC) is being developed in the field of structural heart disease (SHD) along with the advance and refinement of medical equipment for interventional CC. Echocardiography is an indispensable imaging tool as well as fluoroscopy as a guidance of CC. Trans...
25,255,660
[ -0.28671, 0.1713218, -0.0627688, -0.1331768, -0.1091156, -0.03372031, -0.2188406, -0.176365, -0.06601357, -0.186761, 0.1778605, 0.3011298, -0.201194, -0.352899, -0.1971169, -0.137053, -0.3906848, 0.2898408, -0.1624857, 0.09453321, 0.2527325, 0.3139386, -0.134852, 0.2740...
Multifunctional Au-ZnO plasmonic nanostructures for enhanced UV photodetector and room temperature NO sensing devices.
In this study we report the enhancement of UV photodetection and wavelength tunable light induced NO gas sensing at room temperature using Au-ZnO nanocomposites synthesized by a simple photochemical process. Plasmonic Au-ZnO nanostructures with a size less than the incident wavelength have been found to exhibit a local...
25,255,700
[ 0.09228645, -0.2342501, 0.1859127, 0.1616327, 0.03384905, -0.09771479, -0.5472676, 0.02951784, 0.08179288, -0.1262047, -0.1108275, -0.1699457, 0.1422364, -0.3705238, -0.7811118, -0.2719904, -0.4280205, 0.3244321, 0.09661388, -0.1668851, -0.08961782, 0.06065208, -0.0946525...
Congenital central diabetes insipidus and optic atrophy in a Wolfram newborn: is there a role for WFS1 gene in neurodevelopment?
Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by diabetes mellitus (DM), optic atrophy (OA), central diabetes insipidus (CDI) and deafness (D). The phenotype of the disease has been associated with several mutations in the WFS1 gene, a nuclear gene localized on chromosome 4. S...
25,255,707
[ -0.1940438, -0.4870263, 0.2382886, -0.01481233, -0.1664278, -0.5417062, -0.1401098, -0.12105, 0.4509607, 0.09809808, -0.1471994, 0.3826826, 0.04195514, -0.5379134, -0.2394228, -0.236176, 0.2145495, 0.3088631, -0.02090715, -0.5676052, 0.05365421, -0.1779711, -0.1750015, ...
Long-term oncologic outcomes of radical prostatectomy compared with brachytherapy-based approaches for intermediate- and high-risk prostate cancer.
To review the recently published contemporary long-term outcomes from tertiary care urologic practices comparing brachytherapy-based management strategies and radical prostatectomy (RP) across intermediate- and high-risk groups. Literature was reviewed for the past 5 years under the search terms localized prostate canc...
25,255,713
[ 0.0536808, -0.07718788, -0.4287762, -0.3572176, -0.2104019, -0.327323, 0.08365855, -0.01931028, 0.07997717, 0.08535226, -0.01390228, 0.01658021, -0.1033787, -0.2399673, -0.2246782, -0.2039903, 0.08219884, 0.2224345, 0.2818053, -0.3833961, -0.07362458, 0.2353002, -0.119878...
Toxic myopathy and acute hepatic necrosis in cattle caused by ingestion of Senna obtusifolia (sicklepod; coffee senna) in Brazil.
The epidemiological, clinical and pathological findings of field and experimental Senna obtusifolia (sicklepod; coffee senna) poisoning in cattle are described. The low availability of good quality forage and high rate of infestation of pastures by S. obtusifolia were the factors that led to poisonous plant ingestion. ...
25,255,730
[ -0.101772, -0.1546224, 0.4049229, 0.3578131, -0.4104419, -0.1590625, -0.2430006, -0.1903138, -0.1732853, -0.4649199, 0.1155724, 0.1487933, 0.02780804, 0.05900788, 0.02313684, -0.003928308, -0.3330372, -0.3852399, 0.2264583, 0.1450027, 0.1114257, 0.4101673, -0.2371203, -...
Embryological and molecular development of the adrenal glands.
In this mini review, the embryological and functional development of the adrenal glands is presented from a molecular perspective. While acknowledging that this is a highly complex series of events, the processes are described in simple and broad strokes in a single text for the reader who is interested in this field b...
25,255,746
[ -0.16334, -0.009654759, -0.3396652, -0.4141654, 0.1302179, -0.2596478, -0.1465916, -0.08469424, 0.2173429, 0.1350891, 0.1477308, -0.03004338, -0.1063872, -0.1956413, -0.6121191, -0.02547307, -0.1048188, 0.04925168, -0.01684712, 0.0414664, 0.3962456, 0.1103579, -0.1353678,...
Fermented broth in tyrosinase- and melanogenesis inhibition.
Fermented broth has a long history of applications in the food, pharmaceutical and cosmetic industries. Recently, the use of fermented broth in skin care products is in ascendance. This review investigates the efficacy of fermented broth in inhibiting tyrosinase and melanogenesis. Possible active ingredients and hypopi...
25,255,749
[ -0.03848185, -0.5947748, 0.02254973, -0.1690256, 0.1845979, -0.1670871, -0.3511197, 0.1694761, 0.1896928, -0.163741, 0.1065052, -0.1292158, -0.08961727, 0.241151, -0.3756325, 0.1549404, -0.2806538, 0.2229722, 0.03609345, 0.08160894, 0.4409822, 0.2163052, -0.3257667, -0....
Structure and absolute configuration of 20β-Hydroxyprednisolone, a biotransformed product of predinisolone by the marine endophytic fungus Penicilium lapidosum.
The anti-inflammatory drug predinisolone (1) was reduced to 20β-hydroxyprednisolone (2) by the marine endophytic fungus Penicilium lapidosum isolated from an alga. The structural elucidation of 2 was achieved by 1D- and 2D-NMR, MS, IR data. Although, 2 is a known compound previously obtained through microbial transform...
25,255,760
[ -0.319406, 0.07153712, -0.1225582, 0.2492768, -0.1616717, 0.004661081, -0.1799613, 0.1602127, 0.2617053, 0.00808234, 0.1247229, -0.1367798, -0.1598343, -0.2805154, -0.773954, 0.006687503, -0.5457712, 0.500381, 0.02777359, 0.3019208, 0.256866, 0.2545592, -0.1636455, -0.0...
Challenge and opportunity in evaluating a diffusion-based active bystanding prevention program: Green Dot in high schools.
Increasing attention has recently been paid to the development of prevention programs designed to actively engage bystanders in prevention efforts to reduce the risk of sexual and dating violence; yet, few evaluations have been conducted. Our proposed plan to rigorously evaluate a randomized intervention trial of the G...
25,255,794
[ -0.1054929, 0.6518285, -0.1313053, -0.154977, 0.2996585, -0.2259062, -0.4028635, -0.0433501, 0.1054812, -0.1894003, 0.1367209, 0.06117132, -0.2378612, 0.09958944, -0.3463538, 0.0809041, -0.5077242, 0.3561543, 0.3232707, -0.1685649, 0.06342016, 0.4345918, 0.09182828, 0.1...
Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer.
Sipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood. This prospective trial evaluated the direct immune effects of systemically administered sipuleucel-...
25,255,802
[ 0.259636, -0.1751373, -0.2543125, -0.1696882, -0.2641233, -0.6453313, -0.07123914, 0.5262774, 0.09932207, -0.0719992, -0.02183898, 0.4698112, -0.1028849, -0.07078777, -0.575021, -0.3892264, 0.05169187, -0.05483439, 0.05250486, 0.2629929, -0.1286093, 0.2173191, 0.05269153,...
Variations in CYP78A13 coding region influence grain size and yield in rice.
Grain size is one of the most important determinants of crop yield in cereals. Here, we identified a dominant mutant, big grain2 (bg2-D) from our enhancer-trapping population. Genetic analysis and SiteFinding PCR (polymerase chain reaction) revealed that BG2 encodes a cytochrome P450, OsCYP78A13. Sequence search reveal...
25,255,828
[ 0.05514326, 0.3074701, -0.1233426, -0.1404902, 0.1514115, 0.1111854, 0.1286996, -0.1196542, 0.1976314, -0.07371818, 0.1511457, -0.2282997, 0.05044391, 0.214958, -0.5200045, 0.2332661, -0.5677358, 0.1285332, 0.5495953, 0.1344647, 0.3742072, 0.8058918, -0.2070301, -0.0219...
An exploratory study of domains of parenting concern among mothers who are childhood sexual abuse survivors.
This study conducted an exploratory factor analysis and initial validation of Ruscio's (2001) parenting attitudes questionnaire, which assessed parenting concerns among child sexual abuse survivors. Child sexual abuse survivor mothers (N = 60) reported on their abuse experiences and completed the parenting attitudes qu...
25,255,840
[ -0.02477739, 0.3557525, 0.1482274, -0.3551893, -0.1939096, -0.3085529, -0.346256, -0.2542758, 0.2409612, -0.02404749, 0.01736472, -0.3623899, -0.4358683, 0.04724951, 0.09054576, -0.2584976, -0.1291937, 0.1793134, 0.09252989, -0.03486255, -0.08715182, -0.05182857, 0.248828...
An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest: a propensity-matched study.
Prolonged conventional cardiopulmonary resuscitation (CCPR) is associated with a poor prognosis in out-of-hospital cardiac arrest (OHCA) patients. Alternative methods can be needed to improve the outcome in patients with prolonged CCPR and extracorporeal cardiopulmonary resuscitation (ECPR) can be considered as an alte...
25,255,842
[ -0.1210948, 0.1222672, -0.3732293, -0.4286391, -0.2677287, -0.2504013, -0.04164985, -0.08061353, 0.02986509, 0.165763, 0.04474768, 0.5832992, 0.1165582, -0.06366549, -0.1330898, -0.2058342, -0.2485824, 0.2279578, -0.2746263, 0.04618779, -0.2151048, 0.3240795, 0.107135, ...
The modulating effects of endogenous substances on drug metabolising enzymes and implications for inter-individual variability and quantitative prediction.
The cytochrome P450 family of enzymes play an important role in the metabolism of drugs and other xenobiotics. While genotypic variation can contribute to the inter-individual variability in drug metabolism, individuals sharing the same genotype for an enzyme can still show considerable variability in drug metabolising...
25,255,874
[ -0.1005548, -0.06540616, -0.2635383, 0.03282861, 0.04793293, -0.3294333, -0.02352675, 0.04985836, 0.002667055, -0.1313309, 0.1923362, -0.2084282, 0.2805568, 0.2464975, -0.5094935, 0.1680573, -0.6023444, 0.3168127, 0.02707554, 0.314564, -0.1096598, 0.05649275, -0.3288611, ...
Geometrical and optical benchmarking of copper(II) guanidine-quinoline complexes: insights from TD-DFT and many-body perturbation theory (part II).
Ground- and excited-state properties of copper(II) charge-transfer systems have been investigated starting from density-functional calculations with particular emphasis on the role of (i) the exchange and correlation functional, (ii) the basis set, (iii) solvent effects, and (iv) the treatment of dispersive interaction...
25,255,876
[ -0.1755586, 0.2888546, -0.2032594, -0.1607136, 0.2097674, -0.1897343, -0.03341145, -0.07132729, 0.3283991, 0.09241248, -0.2389762, 0.123178, 0.1456455, 0.3196397, -0.9632396, 0.0715023, -0.2140274, -0.0419019, -0.2489426, 0.3899707, 0.1228711, 0.0899663, 0.01563878, -0....
Stable small quantum dots for synaptic receptor tracking on live neurons.
We developed a coating method to produce functionalized small quantum dots (sQDs), about 9 nm in diameter, that were stable for over a month. We made sQDs in four emission wavelengths, from 527 to 655 nm and with different functional groups. AMPA receptors on live neurons were labeled with sQDs and postsynaptic density...
25,255,882
[ 0.0664871, 0.09378812, 0.04441616, 0.05889636, -0.09698101, -0.163624, -0.2384396, 0.05017424, 0.2173807, 0.00614674, 0.1113874, 0.2360769, -0.1359242, 0.08463536, -0.4153142, -0.04787048, -0.5485398, 0.1568477, -0.1028248, -0.04770901, 0.06644588, 0.3205097, 0.09648605, ...
Multiwall carbon nanotubes directly promote fibroblast-myofibroblast and epithelial-mesenchymal transitions through the activation of the TGF-β/Smad signaling pathway.
A number of studies have demonstrated that MWCNTs induce granuloma formation and fibrotic responses in vivo, and it has been recently reported that MWCNT-induced macrophage activation and subsequent TGF-β secretion contribute to pulmonary fibrotic responses. However, their direct effects against alveolar type-II epithe...
25,255,886
[ -0.3727474, -0.07296095, -0.08014943, -0.07200986, -0.08548237, -0.02209519, -0.3241887, 0.01614011, -0.1782007, 0.2427036, -0.04340703, 0.0244524, -0.1495788, -0.1230673, -0.4100218, -0.04388644, -0.4821164, -0.07171766, -0.03532469, 0.05203515, -0.3472286, 0.2985224, -0...
The clinical anatomy of the conal artery.
Coronary arteries have been extensively described and recognized by gross anatomic studies. However, in the clinical setting, the recognition of the conal artery is essential during coronary angiography, as well as certain congenital heart conditions such as tetralogy of Fallot. In order to provide a complete anatomic ...
25,255,889
[ 0.1287362, -0.02687665, -0.1922939, 0.2304287, 0.03650858, -0.06839343, 0.07960167, 0.1635768, 0.006559464, 0.3353604, 0.1035185, 0.02731075, 0.02687524, -0.3220885, 0.152512, -0.1226638, -0.05762669, 0.272861, 0.1668499, -0.05881375, 0.1150481, 0.5066638, -0.3311998, 0...
Effect of diabetes on hospitalization for ischemic stroke and related in-hospital mortality: a study in Tuscany, Italy, over years 2004-2011.
Incidence of ischemic stroke and associated in-hospital mortality is decreasing in Western populations, while the prevalence of diabetes, a well-known risk factor for ischemic stroke, is progressively rising. This study was aimed at evaluating the effect of diabetes on ischemic stroke hospitalization and in-hospital mo...
25,255,901
[ -0.2121408, 0.02625925, -0.09821979, 0.218361, 0.04904492, -0.2909825, 0.1609812, -0.1219398, -0.1578372, 0.2274017, -0.2904293, 0.2580886, -0.06298228, -0.3654454, 0.0122422, -0.4101052, 0.2806034, 0.3236168, -0.2647357, -0.2203464, -0.00100203, 0.1811155, -0.0868874, ...
Evidence on access to medicines for chronic diseases from household surveys in five low- and middle-income countries.
The 2011 United Nations (UN) General Assembly Political Declaration on Prevention and Control of Non-Communicable Diseases (NCDs) brought NCDs to the global health agenda. Essential medicines are central to treating chronic diseases such as hypertension and diabetes. Our study aimed to quantify access to essential medi...
25,255,920
[ -0.09534234, 0.1565575, 0.1323316, -0.04159178, 0.285491, -0.1818708, -0.005791334, 0.1294302, 0.2306289, -0.1778046, 0.1000747, -0.1329207, 0.02269739, 0.1593039, -0.13382, 0.04340581, 0.08187216, 0.2230589, -0.3363629, -0.1767422, 0.007480503, 0.1184063, -0.1023225, 0...
Silencing of PNPLA6, the neuropathy target esterase (NTE) codifying gene, alters neurodifferentiation of human embryonal carcinoma stem cells (NT2).
Neuropathy target esterase (NTE) is a protein involved in the development of a polyneuropathy caused by exposure to certain organophosphorus compounds. In vivo and in vitro studies have also associated NTE with embryonic development since NTE null mice embryos are non-viable, and silencing the NTE-codifying gene (Pnpla...
25,255,935
[ -0.1602272, -0.3110919, 0.1017601, -0.3331987, -0.02803322, -0.3255022, -0.07663058, 0.05596213, 0.1709448, 0.01181172, 0.3444186, 0.06487783, -0.009560767, -0.3314226, -0.38492, -0.0695403, -0.2501582, 0.02849118, -0.3023176, 0.3502223, -0.02423357, 0.2653412, -0.186887,...
Identification and expression of GnRH2 and GnRH3 in the black sea bass (Centropristis striata), a hermaphroditic teleost.
We cloned two cDNAs for two gonadotropin-releasing hormones, GnRH2 (chicken GnRH-II) and GnRH3 (salmon GnRH), respectively, from the black sea bass (Centropristis striata). Black sea bass are protogynous hermaphroditic teleosts that change from females to males between 2 and 5 years of age. Similar to other GnRH precur...
25,255,937
[ 0.146032, 0.07121712, 0.13688, -0.3064194, -0.1470348, -0.238671, 0.05245208, 0.1361108, 0.1342085, 0.1173223, 0.2889249, -0.1890538, -0.2365239, -0.2006886, -0.1521513, -0.2475506, -0.3922574, 0.2663987, 0.5335853, -0.3539883, 0.3333123, 0.4140968, -0.2052611, -0.35086...
3D GABA imaging with real-time motion correction, shim update and reacquisition of adiabatic spiral MRSI.
Gamma-aminobutyric acid (GABA) and glutamate (Glu) are the major neurotransmitters in the brain. They are crucial for the functioning of healthy brain and their alteration is a major mechanism in the pathophysiology of many neuro-psychiatric disorders. Magnetic resonance spectroscopy (MRS) is the only way to measure GA...
25,255,945
[ -0.09813279, -0.09654931, -0.715809, -0.04406525, 0.1160987, -0.139507, -0.1351838, 0.03525594, -0.0518457, -0.3050112, -0.07762801, 0.08605526, 0.3433897, 0.05245778, -0.7112809, 0.2551205, -0.2909723, -0.1526512, -0.256804, 0.132787, 0.1288249, 0.3238873, 0.04343682, ...
Transcriptome profiling of the testis reveals genes involved in spermatogenesis and marker discovery in the oriental fruit fly, Bactrocera dorsalis.
The testis is a highly specialized tissue that plays a vital role in ensuring fertility by producing spermatozoa, which are transferred to the female during mating. Spermatogenesis is a complex process, resulting in the production of mature sperm, and involves significant structural and biochemical changes in the semin...
25,255,964
[ -0.1766056, -0.06272792, 0.283131, 0.1018143, -0.05277731, -0.3621408, -0.04848379, 0.006425233, 0.06181297, 0.09364053, 0.2476122, -0.1154517, -0.1460576, 0.134813, -0.7193825, 0.3147262, -0.4975899, 0.01515306, 0.1039144, -0.2253838, 0.2249182, 0.3822344, -0.2613475, ...
Protecting worker and public health during responses to catastrophic disasters-learning from the World Trade Center experience.
Despite incremental lessons learned since 9/11, responder and community health remain at unnecessary risk during responses to catastrophic disasters, as evidenced during the BP Deepwater Horizon spill and Hurricanes Katrina, Rita, and Sandy. Much of the health harm that occurs during disaster response, as distinct from...
25,255,981
[ -0.1784191, -0.1746889, 0.05694919, -0.2214501, -0.165235, 0.02994025, -0.2683494, -0.04903387, 0.1613295, -0.1356244, 0.3095904, -0.3143449, 0.001296601, -0.03833329, -0.4178668, -0.04666114, -0.4234608, -0.03444316, 0.1599414, -0.2834197, -0.338879, 0.451264, -0.2351185...
Construction of 3D polymer brushes by dip-pen nanodisplacement lithography: understanding the molecular displacement for ultrafine and high-speed patterning.
Dip-pen nanodisplacement lithography (DNL) is a versatile scanning probe-based technique that can be employed for fabricating ultrafine 3D polymer brushes under ambient conditions. Many fundamental studies and applications require the large-area fabrication of 3D structures. However, the fabrication throughput and unif...
25,256,006
[ -0.09763344, 0.1124657, 0.05600825, 0.3149038, 0.1133966, -0.1108953, -0.5001923, 0.2124614, 0.2202374, 0.4543676, -0.05141795, -0.1150004, -0.06093339, 0.09132033, -0.3340717, -0.271429, -0.3357226, 0.1574286, 0.01946895, -0.09296191, 0.1935067, 0.0002831762, -0.1593901,...
Association between MTHFR C677T polymorphism and congenital heart disease. A family-based meta-analysis.
Congenital heart disease (CHD) is the most common type of birth defect. It is suspected that polymorphisms in folate metabolism are associated with an increased risk of CHD, but the conclusion remains unclear. Studies have reported that the MTHFR C677T polymorphism was associated with the development of structural cong...
25,256,053
[ -0.1681728, 0.047268, -0.2648895, 0.04562562, 0.1194493, -0.092265, 0.009392703, -0.03877322, -0.1852925, 0.07598155, 0.2773451, 0.4758875, -0.1579389, 0.2932287, -0.02171091, -0.2030059, -0.5905411, 0.2228324, -0.07601576, 0.2066646, -0.1051166, 0.4127902, -0.2461534, ...
Multiple independent colonization of the Canary Islands by the winged grasshopper genus Sphingonotus Fieber, 1852.
Volcanic archipelagos represent ideal systems to study processes of colonization, differentiation and speciation. The Canary Islands are one of the best studied archipelagos, being composed of seven main islands with a well-known geological history. Most taxa have colonized these islands stepwise from the African or Ib...
25,256,055
[ -0.02610833, -0.003315421, 0.2000161, -0.1009843, -0.08187114, -0.369563, -0.4249267, -0.1174422, 0.1490161, -0.04408078, -0.08324248, -0.4845946, 0.07374892, -0.2656259, -0.5045353, -0.1358733, -0.5319355, -0.08590095, 0.04026178, -0.1485562, -0.01825557, 0.2156879, -0.0...
Excretion of tectoridin metabolites in rat urine and bile orally administrated at different dosages and their inhibitory activity against aldose reductase.
This study investigated the urinary and biliary excretion of tectoridin, a major active isoflavonoid found in the flowers of Pueraria thomsonii Benth. and the rhizomes of Belamcanda chinensis (L.) DC. Using UHPLC/Q-TOFMS, seven glucuronides and/or sulfated metabolites and four Phase I metabolites were simultaneously qu...
25,256,063
[ 0.07304239, 0.1988285, -0.1478501, 0.1885679, 0.4168667, 0.008049328, -0.1074155, 0.1112992, -0.08303168, 0.00186963, 0.3782766, -0.2912732, 0.04385019, -0.2126595, -0.2535058, 0.1365044, -0.6240625, -0.02915961, 0.07679676, 0.0001141756, 0.3703557, 0.4121647, 0.01242384,...
Microinjection of cocaine- and amphetamine-regulated transcript 55-102 peptide into the nucleus accumbens could modulate anxiety-related behavior in rats.
Cocaine- and amphetamine-regulated transcript (CART) peptide is abundantly expressed in the nucleus accumbens (NAcc) and is involved in stress, anxiety and reward responses. To examine the role of CART peptide in anxiety-related behavior, naïve rats were bilaterally injected with CART 55-102 peptide (0.5, 1.0 or 2.5 µg...
25,256,086
[ -0.008460892, 0.09716328, -0.3397955, -0.03418825, -0.05647561, -0.3952198, -0.225434, -0.1732597, -0.04504411, -0.1452786, 0.09457058, 0.2253625, 0.1304297, 0.1401957, 0.0858268, -0.2662588, -0.4227791, 0.2556802, -0.09120133, 0.007099156, 0.0921306, 0.01654808, 0.229402...