title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Isolation and purification of a small molecular weight hydroxyproline-containing structural glycopeptide from early mammalian granulation tissue. | A small molecular weight structural glycopeptide was solubilized after collagenase digestion of the connective tissue capsule surrounding the 5-day sponge-implant of the rat. The major amino acids are one residue each of aspartic and glutamic acids, proline, hydroxyproline and alanine and two residues of glycine, and the carbohydrates are one residue each of glucose, xylose and hexosamine and two residues of mannose. The sum of the amino acid and carbohydrate residues gives a molecular weight of 1635. Dansylation of the glycopeptide produces a single strongly fluorescent yellow-orange amino-terminal spot, not positively identified. The solubilization of the granuloma glycopeptide by collagenase and its composition are suggestive of its association with an immature form of collagen in early granulation tissue. | 144,581 | [
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[Effect of talliblastine on several hematologic indices]. | The authors carried out a study on the blood formation of healthy experimental animals after treatment with the potential antitumours agent taliblastine in view of clarifying its influence. The experiments were undertaken on inbred mice DVA/2 and rats on the Wistar strain. Taliblastine was administered intraperitonealy: in ice-aingly and in a 5-day course, but in rats only in a 5-day course. The substance was administered after single treatment with doses of LD50 maximal threshold limit dose (MTD), but in the dourses with MTD and 1/2 of MTD. They examined the changes in hemoglobin, number of leucocytes, erythrocytes, thrombocytes and reticulocytes, but in rats-the number of bone-marrow cells as well. The values of hematological indices were determined 24 hours, 10 and 30 days after conclusion of the administration of taliblastine. It was established that taliblastine did not affect substantialy the values of hemoglobine and caused transitory changes in the absolute number of leucocytes and lymphocytes. | 144,597 | [
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The isolation and characterization of differentially phosphorylated fractions of phosphofructokinase from rabbit skeletal muscle. | A preparation of phosphofructokinase from rabbit skeletal muscle is described which exploits the association-dissociation properties of the enzyme. Phosphofructokinase to prepared is partially phosphorylated and may be fractioned into three distinct species with sedimentation coefficients of 30 S, 18 S and 13 S by chromatography of agarose gels, hydroxyapatite or DEAE-cellulose. Measurements of alkali-labile phosphate content (phosphoserine and/or phosphothreonine) show that fractions consisting almost exclusively of 30-S species and fractions consisting predominantly of 18-S and 13-S species contain approximately 0.15 and 0.29 mol of phosphate per phosphofructokinase monomer (Mr = 80000) respectively. The results are interpreted in terms of at least two 13-S components which differ in their phosphate contents and also in their self-association properties. The possible significance of phosphorylation is discussed. | 144,600 | [
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[Mechanism of the hypobilirubinemic action of nicofezon]. | The effect of nicophesone on the processes of cojugation and alkaline phosphatase was studied in tests staged on albino rats and rabbits poisoned with carbon tetrachloride (CCl4). Nicophesone is shown to stimulate conjugation of bilirubin with glucoronic and sulphuric acids and to depress the activity of alkaline phosphatase. The data obtained are considered inasmuch as they concern the hypobilirubinemic action of nicophesone. | 144,607 | [
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[Improved scintigraphic imaging of the adrenals with 6beta-131I-iodomethyl-cholesterol (author's transl)]. | Scintigraphic visualization of the adrenals is greatly improved after substitution of 131I-19-I-Cholesterol by 6beta-131I-Iodomethyl-Cholesterol which was first seen as a radiochemical impurity during the synthesis of 131I-19-Iodocholesterol. The interpretation of the scintigraphic imaging is further improved by application of a cross section through the visualized adrenals. In an animal experiment the radioactivity of the adrenals and to a less degree that of different tissues was found up to four times higher after injection of 6beta-131I-Iodomethyl-Cholesterol than with the applications of 131I-19-Iodocholesterol. The high affinity of the tissue for 6beta-131I-Iodomethyl-Cholesterol results in high radiation exposure of the patients. However, since less activity of 6beta-131I-Iodomethyl-Cholesterol is necessary for visualization of the adrenals the overall radiation is also less than with the application of 131I-Iodocholesterol. Higher stability of the labelled molecule is suggested to be responsible for improved scintigraphic imaging of the adrenals. | 144,660 | [
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[Arthrography of the hand in an accident clinic (author's transl)]. | By 115 arthrographies of the wrist in patients with posttraumatic pain, the importance of the method for diagnosis in injured patients is discussed. It was possible to detect 29 cases with a lesion of the articular disc, 4 patients with ruptured radiocarpal joint and 3 cases with an injury of the distal radioulnar joint. The technique of filling the wrist is described and different manifestations of "normal" arthrogramms are exhibited. | 144,681 | [
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[Side effect of metrizamide and meglumine iocarmate in lumbar myelography. A prospective, parallel, interview study (author's transl)]. | Side effects of metrizamide (Amipaque) and meglumine iocarmate (Dimer-X) were compared in lumbar myelography of 161 patients by a prospective, parallel, interview study. Severe complications were not observed. The percentage pairs of smaller complications were mainly in favour of Dimer-X, but in 2 of the 54 pairs only the difference did raise to a significant level. In one pair there were less symptomless patients after Amipaque-myelography (p less than 0.05) and in another pair the men had more headache after Amipaque-myelography (p less than 0.01). It may be possible to show with larger comparative series, that Amipaque has a tendency to cause more central-subcortical or meningeal-side effects than Dimer-X. | 144,686 | [
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Papular mucinosis. | Most patients previously reported to have papular mucinosis had the generalized lichenoid papular form (scleromyxedema) with abnormal gamma globulin. Microscopic examination of affected skin showed increased acid mucopolysaccharides in the dermis and proliferation of fibroblasts. Our patient had the discrete form of papular mucinosis without abnormal serum gamma globulin but with increased amounts of acid mucopolysaccharides in the dermis and no proliferation of fibroblasts. | 144,708 | [
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Some determinants of the reinforcing and punishing effects of timeout. | Some determinants of the reinforcing and punishing properties of timeout were investigated in two experiments. Experiment I began as an attempt to reduce the frequency of tantrums in a 6-yr-old autistic girl by using timeout. Unexpectedly, the result was a substantial increase in the frequency of tantrums. Using a reversal design, subsequent manipulations showed that the opportunity to engage in self-stimulatory behavior during the timeout period was largely responsible for the increase in tantrums. Experiment II was initiated following the failure of timeout to reduce the spitting and self-injurious behavior of a 16-yr-old retarded boy. Using a multiple-baseline design, the nature of the timein environment was shown to be an important determinant of the effects of timeout. When the timein environment was "enriched", timeout was effective as a punisher. A conception of timeout in terms of the relative reinforcing properties of timein and timeout and their clinical implications are discussed. | 144,719 | [
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Inhibition of proteases in coagulation, kinin-forming and complement systems by alpha2-plasmin inhibitor. | Inhibitory activities of alpha2-plasmin inhibitor against various proteases were investigated. The inhibitor promptly inhibited the esterolytic activity of alpha-chymotrypsin and progressively inhibited the esterolytic or amidolytic activities of bovine plasma kallikrein, bovine thrombin and bovine activated factor X. Heparin had no effect on the reaction of the inhibitor with thrombin or activated factor X. However, the inhibitor had no effect on the activities of human C-1-esterase, papain and snake venom kininogenase. On the basis of its rapid inhibition of kallikrein, alpha2-plasmin inhibitor is considered to exert some regulating effect on kallikrein activity in plasma. | 144,728 | [
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Metabolism of crufomate [(4-tert-butyl-2-chlorophenyl methyl methylphosphormidate)] by the rat. | Fifteen metabolites of crufomate (4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate, I) were identified in the excreta from rats given single oral doses of I. Compound I was not detected in either the urine or the feces. The metabolic reactions observed were N-and O-demethylation, oxidations of the t-butyl moiety, replacement of the H-N-CH3 with an OH moiety, hydrolysis of the phosphoramidate moiety to yield the phenol, conjugation with glucuronic acid, and combinations of these reactions. No ring dehalogenation or ring substitution was observed. | 144,748 | [
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Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform. | Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration of phenylephrine, a directly acting alpha-adrenergic agonist, with chlordimeform did not increase the lethality of chlordimeform. Thus, monoamine oxidase inhibition by chlordimeform does not seem to contribute to its lethality. | 144,803 | [
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Metabolic changes with inflammation induced by a surfactant. | Studies were carried out to determine the relationship between metabolic histopathological changes in the gastrocnemius muscle of rats in which an acute exudative inflammation had been induced by alkyldimethylbenzylammonium chloride (alkyl-DBAC, a cationic surfactant). Succinate respiration, Na+-K+-Mg2+ ATPase activity and ATP, ADP and AMP levels were determined as the index of metabolic changes. Myofascial edematous swelling with the acceleration of succinate oxidation and Na+-K+-Mg2+ ATPase activity was noted at 30 minutes in the inflamed muscle. The ATP level was also transiently reduced. On the other hand, Na+-K+-Mg2+ ATPase activity and succinate oxidation were inhibited by alkyl-DBAC, at this concentration, in vitro. These results support the possibility that enhancement of energy metabolism is not directly initiated by alkyl-DBAC but may be the result of certain chemical mediators released by alkyl-DBAC. The enhancement of energy metabolism continued after 1 hour and this energy may initiate leukocyte migration as well as increase vascular permeability and edema. | 144,813 | [
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[Therapy of androgenization symptoms: double blind study of an antiandrogen preparation (SH B 209 AB) against neogynon (author's transl)]. | The antiandrogen-containing preparation SH B 209 AB was tested in comparison with an ovulation inhibitor with no antiandrogenic effect (Neogynon) in a randomized, double blind study conducted to determine the effects of both on androgenization symptoms. 88 patients took part in the study. In the majority of cases the duration of the treatment period was more than 6 months. It was shown that the therapy with the combination preparation containing cyproterone acetate was distinctly more successful in cases of acne and seborrhoea: not only acne in its various locations but also all forms of seborrhoea were more favourably influenced by the trial preparation. This difference was statistically significant (p less than 0.05). It was not possible to establish a significant difference between the two preparations in the case of hirsutism in its various locations from the limited number of cases observed. There were also no differences detected in hepatic tolerance. During treatment with both preparations all values measured were within the normal range. | 144,842 | [
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Nuclear-extranuclear interactions affecting oligomycin resistance in Aspergillus nidulans. | The extranuclear mitochondrial oligomycin-resistant mutation of Aspergillus nidulans, (oliA1), was transferred asexually into four nuclear oligomycin-resistant strains of different phenotypes. In all four cases, the possession of the nuclear plus extranuclear mutation led to an increase in the in vivo level of oligomycin resistance. In two cases, the altered cytochrome spectrum and impaired growth ability determined by (oliA1) were suppressed by the nuclear mutations. In the third case, the in vitro oligomycin resistance of the double mutant ATPase was dramatically increased above that of either of the component single mutant strains, indicating a synergystic interaction between the nuclear and extranuclear gene products. In the fourth case, the double mutant became cold-sensitive. A new extranuclear mitochondrial oligomycin-resistant mutation (oliB332) is described. This mutant is phenotypically similar to, though not identical with, (oliA1) but is separable by recombination. A range of nuclear oligomycin-resistant mutants have been mapped. Despite presenting five distinctly different phenotypes, they all map at the same locus. | 144,864 | [
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Differences between functional versus organic low back pain patients. | There are contradictory findings about whether there are differences in personality and/or amount of emotional disturbance between patients with functional versus organic low back pain. The MMPI scores of 42 back pain patients diagnosed as "organic" were compared with the scores of 37 patients classified as "functional". The functional patients scored significantly higher than the organics on the Hs, Hy, Pd, Sc, Ma, and Si scales. The organics scored significantly higher than the functionals on the K scale. The results confirm the view that certain symptoms of emotional disturbance are more characteristic of patients who have relatively little evidence of physical findings. However, the degree of overlap between groups was high enough to suggest caution in making predictions and diagnoses about functional versus organic pain on individual patients solely on the basis of personality data. | 144,890 | [
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Migration of Escherichia coli dnaB protein on the template DNA strand as a mechanism in initiating DNA replication. | The first step in conversion of varphiX174 singlestranded DNA to the duplex replicative form in vitro is the synthesis of a nucleoprotein intermediate [Weiner, J. H., McMacken, R. & Kornberg, A. (1976) Proc. Natl. Acad. Sci. USA 73, 752-756]. We now demonstrate that dnaB protein (approximately one molecule per DNA circle) is an essential component of the intermediate and retains its ATPase activity. Synthesis of RNA primers, dependent on dnaG protein (primase), occurred only on DNA that had been converted to the intermediate form. In a coupled RNA priming-DNA replication reaction the first primer synthesized was extended by DNA polymerase III holoenzyme into full-length complementary strand DNA. In RNA priming uncoupled from replication, multiple RNA primers were initiated on a varphiX174 circle. The single dnaB protein molecule present on each DNA circle participated in initiation of each of the RNA primers, which appear to be aligned at regular intervals along the template strand. We propose that dnaB protein, once bound to the template, migrates in a processive fashion along the DNA strand, perhaps utilizing energy released by hydrolysis of ATP for propulsion; in this scheme the actively moving dnaB protein acts as a "mobile promoter" signal for dnaG protein (primase) to produce many RNA primers. Schemes are proposed for participation of dnaB protein both in the initiation of replication at the origin of the Escherichia coli chromosome and in the initiation of primers for nascent (Okazaki) fragments at a replication fork. | 144,914 | [
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[Simplified diagnostic scheme for Enterobacteriaceae]. | After testing 18 experimental variants against 40 reference strains belonging to different Enterovacteriaceae groups, the authors chose a multitest medium that permits concomitant testing of mobility, indol, lysinedecarboxylase and phenylalanine deaminase (MILP). In this medium, the reactions of 3734 strains belonging to the genera Escherichia, Shigella. Salmonella, Citrobacter, Klebsiella, Enterobacter, Serratia. Proteus and Providencia were concordant with the reactions in individual test media, taking as reference, in a proportion of 99.7 and 100%. The authors, associating the MILP medium to TSI agar, propose a simple scheme consisting of eight test which permits, within only 24 hours, the correct identification of the genus and sometimes of the species of cultures or isolated colonies from selective media. | 144,994 | [
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Distribution of water between extracellular and intracellular compartments of incised wounds of rabbits. | The distribution of water between the extracellular and intracellular compartments in incised wounds of skin, muscle and stomach has been studied in healthy rabbits and the progress of healing monitored by the determination of tensile strength for 120 days. It has been shown that, after wounding, there is an immediate expansion of the extracellular space. The increase is most marked during the first 24 hours and is maximal by this time in wounds of the skin and the muscle. During the first 30 days of healing, all incised tissues contain similar amounts of extracellular water which constitute approximately one-half of the total tissue mass, irrespective of the size of the extracellular space prior to wounding. There is an inverse relationship between the increase in the amount of extracellular water and the size of the extracellular space prior to wounding. All incised tissues maintain an elevated, and similar, concentration of extracellular water for more than 120 days. The period of maximal gain in tensile strength corresponds to the period of maximal expansion of the extracellular space which signifies a particularly active phase in the wound healing process. The intracellular space in wounds of muscle and stomach is reduced for more than 120 days, but no significant changes are seen in the intracellular water of wounds of skin. It has been concluded that expansion of the extracellular space is essential for wound healing, and it can, therefore, serve as a sensitive indicator of tissue injury. | 145,028 | [
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[Benzoyl peroxide in the treatment of acne vulgaris (author's transl)]. | 63 patients suffering from predominantly papulo-pustular acne vulgaris were treated with 5-10% benzoyl peroxidegel over a period of 2-4 months. The skin condition showed marked improvement in 80% of the patients. Two patients developed cutaneous allergy. Benzoyl peroxide is the therapy of choice for the inflammatory form of acne vulgaris. Systemic tetracyclines need not be given concomitantly. Autoradiographic studies revealed that benzoyl peroxide also has a truly sebostatic effect. | 145,097 | [
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[Cellular immunity during and after high-dose methotrexate therapy in patients with osteosarcoma (author's transl)]. | Nine patients with osteogenic sarcoma and one patient with epitheloid sarcoma of bone undergoing treatment with high-dose methotrexate (MTX) therapy were studied immunologically. The following peripheral blood lymphocyte parameters were evaluated: 1-8 days after the intravenous infusion of 7.5 g MTX followed by leucovorin rescue: absolute count/mm3, the stimulatory response to the mitogens, phythemagglutinin (PHA) and pokeweed (PW) and the reactivity in the mixed lymphocyte culture (MLC). The response to PHA remained unaffected during the observation period, whereas the response to PW decreased on the 2nd and 4th day after treatment. The MLC response was inhibited between the 1st and the 4th day. The inhibition manifested itself first in the patients plasma and was demonstrable 48 hours later in the lymphocyte itself. The responsiveness regained normal or even reacted supranormal values about 7 days after treatment. Lymphocyte function remained essentially unaltered after several cycles of treatment. Absolute lymphocyte counts, however, tended to decrease. The MTX sensitive period in vitro lasts from the 2nd to the 6th day of the MLC, which is the period of intense RNA and DNA synthesis. We conclude that high-dose MTX therapy for osteogenic sarcoma leaves the patient without major permanent damage to cellular immune function. | 145,098 | [
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[The effect of cardiovascular hypertrophy on the work capacity of hypertensive patients]. | Hypertensive persons with pathological ECG in rest compared with healthy persons and hypertensives with normal ECG in rest show a significantly decreased physical efficiency. In hypertensives in stage II disturbances in form of references to a stress heart insufficiency, to a stress coronary insufficiency and a circulatory dysregulation are the cause of the disturbed function of the circulation. Thus the pathological ECG in rest in the hypertensive is an important diagnostic and prognostic criterion for practice. | 145,101 | [
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Structure and anticholinesterase activity of series of ethyl substituted phenyl methylphosphonates. | Thirty derivates from substituted-phenyl-ethyl methylphosphonates have been synthesized and their inhibiting power of acetyl-cholinesterase have been examined in vitro and in vivo. The correlation between inhibition of the enzyme and electrophylic power of the substituent of the phenyl group was excellent, but when this group contains two substituents, steric factors appear to operate. The activity of these compounds has been demonstrated to be higher than their phosphate analogs. | 145,115 | [
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Hydroxycinnamoyl: coenzyme A transferase involved in the biosynthesis of kaempferol-3-(p-coumaroyl triglucoside) in Pisum sativum. | The major flavonoids of Pisum are derivatives of kaempferol and quercetin, including both triglucosides and acylated triglucosides in which the acyl group is p-coumaric acid. Although hydroxycinnamic acid esters of flavonoids are common pigments in many plants, neither the enzymes nor the precursors involved in their biosynthesis have been demonstrated. We report here that crude enzyme preparations extracted from peas catalyze the transfer of the p-coumaroyl moiety of p-coumaroyl:Coenzyme A to kaempferol-3-triglucoside forming kaempferol-3-(p-coumaroyl triglucoside) as the acylated product. The reaction product has been vigorously shown to be identical to the naturally occurring kaempferol-3-(p-coumaroyl triglucoside) in both chromatographic and chemical properties. The enzymatic formation of the acylated derivative occurred only minimally when incubated with the cofactors required for carboxyl group activation (ligase) and maximally when incubated with p-coumaroyl : Coenzyme A as the acyl donor. | 145,116 | [
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Development of phage populations in a bacterial culture: a mathematical model. | A mathematical model for the interaction kinetic in phage-bacterium culture is proposed. An appropriate analytical relationship between phage and bacterial concentrations has been derived. Characteristic kinetic constants have been obtained by comparing the experimental growth curves with computer-simulation analysis. The model allows also to evaluate the phage-yield as a function of the initial concentrations. | 145,125 | [
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The activity of Golgi-membrane galactosyltransferase in the liver of streptozotocin-diabetic rats. | The Golgi-rich membrane fraction isolated from streptozotocin-diabetic rat liver had a lower protein content than the corresponding fraction from normal liver. Its UDPgalactose-N-acetylglucosamine galactosyltransferase activity calculated per 1 g of liver or whole liver was decreased. The electron-microscopic examination of the negatively stained fraction revealed morphological changes. The morphology of the Golgi complex in thin sections of diabetic liver was also changed. | 145,156 | [
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[Centronuclear myopathy (author's transl)]. | Three cases of centronuclear myopathy are reported in a sibship. The disease starts during the late childhood and has a very slow progressive course. Clinical examination reveals a ptosis of the eyelids, a weakness of the facial muscles, a high-arched palate and a diffuse involvement of the lower extremities. The respiratory muscles are involved in the two oldest siblings. Combined morphological studies of the tibialis anterior muscle in one patient demonstrate the following features: 1. the presence of small type I fibres and of large type I or type II fibres; 2. a predominance of type I fibers which represent 86% of the total amount of muscle fibres; 3. central nuclei in about 98% of the muscle fibres; 4. moderate ultrastructural changes. All these features are compared with the relevant data of the literature. | 145,158 | [
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Normal chemotactic activity of granulocytes obtained by filtration leucapheresis. | The chemotactic activity of granulocytes obtained by the Terumo Filtration Leucapheresis System (F.L.) was examined by the method of Boyden's chamber. The number of cells migrating through the Millipore filter was expressed as the chemotactic activity. The mean values were 117 for the F.L. and 122 in a control, in which cells were collected from the same donor blood using dextran sedimentation. The results suggested that the in vitro chemotactic function of granulocytes obtained by F.L. was within normal limits. | 145,164 | [
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[Influence on the function of lymphocytes in children with generalised mycosis during treatment with 5-fluorocytosin (author's transl)]. | After LT Tests with PHA, PPE and Candidin in mixed cultures negativ or decreased results of cellular immunoreactions were obtained in cases of generalised mycosis, taking into account age-specific variations. The generalised form of mycosis having disappeared, the findings returned to normal. While in other diseases the use of metabolites always diminishes cellular immunoreactions, there is no decrease of lymphozyte transformation during treatment with 5-fc in mycosis. After a successful therapy even an increase may be found in this case. Our studies confirm the opinion that 5-FC does not influence the function of T-lymphocytes. | 145,175 | [
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Head Start has little to do with mental retardation: a reply to Clarke and Clarke. | Clarke and Clarke's (1977) critique of Head Start in an editorial on mental retardation is based upon questionable assumptions, a selective review of research, and errors in fact. There is considerable evidence that Head Start has improved the social competence of economically disadvantaged children. | 145,182 | [
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[A comparative study of the development of trisomy 21 concepti and the growth of their cells in vitro]. | Children with trisomy 21 are only a part of conceptuses with this anomaly which leads mainly to early arrests of development. Growth retardation of embryo and placenta are the main characteristics of these abortuses. Cell lines were established from tissues of trisomics 21 of different types of evolution (early spontaneous abortions, abortions after prenatal diagnosis, stillbirths and newborn-infants). Differences in the in vitro growth characteristics of these cells have been evidenced. They may explain the variations in the developmental potentials of trisomy 21 conceptuses. | 145,209 | [
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A double-blind study of the effect of zinc and oxytetracycline in acne vulgaris. | With a double-blind technique, the effects of oral zinc and tetracyclines were compared in 37 patients with moderate and severe acne. No difference in effect between the treatments was seen and no side-effects were noted in any group. After 12 weeks of treatment, the average decrease in the acne score was about 70% in both groups. | 145,237 | [
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Changes in the activities of some membrane-associated enzymes during in vivo ageing of the normal human erythrocyte. | Human erythrocytes from healthy male donors were fractionated with respect to in vivo age by simple centrifugation in order to characterize changes in the functional integrity of the membrane during the life-span of the cell. The three enzymes, Na/K-ATPase, glyceraldehyde-3-phosphate dehydrogenase and NADH-ferricyanide reductase, were found not to change with age, but significant age-dependent decreases were observed in the cases of acetylcholinesterase, phosphoglycerate kinase, purine nucleoside phosphorylase, adenylate kinase, Mg-ATPase and alkaline phosphatase. The possibility that these changes were attributable to mechanisms other than age-related inactivation, such as reticulocyte contamination, differential resealing and crypticity, was investigated. Only the decrease in acetylcholinesterase could be explained wholly in terms of reticulocyte contamination. A decrease in membrane integrity on ageing was observed, which accounted for approximately half the change in alkaline phosphatase and may have contributed to the other enzyme activity changes. This membrane integrity effect masked a real decrease in the highly cryptic NADH-ferricyanide reductase, this decrease being apparent only after total disaggregation of the membrane with nonionic surfactant. | 145,240 | [
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Histology of the capsules causing constrictive fibrosis around breast implants. | Histological features seen in 9 capsules formed around breast prostheses with Dacron patches were described. Dacron evoked a marked foreign body reaction and fibroplasia. Parts of the silicone layer in which the Dacron fibres were originally anchored may also get into the capsule together with the Dacron. The main cause of fibrotic thickening in the capsules was contamination of the tissues with a foreign material, very probably silicone. The contamination of the capsules showed individual and local variation, with no definite correlation to the time which has elapsed since implantation. | 145,256 | [
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[Plasma concentration and metabolic clearance rate of aldosterone at weaning, at puberty, and in adult guinea pigs]. | Plasma aldosterone concentrations were measured by radioimmunoassay and metabolic clearance rates (M.C.R.) were determined by a continuous infusion of H3-aldosterone on day 20 and 50 and at 3, 6 and 24 months in the male and the female guinea-pig. Plasma aldosterone concentration rose gradually from day 20 up to 24 months. At every stage the values were always higher in the female than in the male. M.C.R. (1/24 h/100 g) decreased from day 20 to 24 months and appeared to be sex-dependent in the guinea-pig. | 145,280 | [
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[Cholinesterases and arylesterase in the umbilical cord, the placenta, and the amniotic membrane, in the female at term]. | Cholinesterasic activity of umbilical cord (tissue), completely bloodless, is exclusively due to pseudocholinesterase. Cholinesterase is more active in placenta than in cord; it is an acetylcholinesterase at 80 per cent. Both forms coexist, about equally, in amniotic membrane. A considerable arylesterasic activity is proved in cord, placenta and membrane, the greatest activity being in placenta. Comparing the greater activity in maternal plasma and cord blood's plasma to the very weak activity in amniotic fluid, it is possible to think that cork, membrane, placenta and also amniotic fluid pseudocholinesterase and arylesterase, come from plasma. On the contrary, placental acetylcholinesterase seems original and probably is the source of this enzyme activity in amniotic fluid. | 145,288 | [
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[Lack of concordance in the effect of large doses of phenformin on insulin secretion and glycemia. Tentative analysis]. | In the anesthetized dog normal or pretreated with phenformin (20 mg/kg per os) for 7 days, a subcutaneous injection of this biguanide (20 mg/kg) triggers a considerable hyperinsulinemia without concomitant hypoglycemia. The insulin secreted by these animals is biologically active on rat epididymal fat pads. On the other hand, epididymal fat pads of rats pretreated with phenformin display a lower response to insulin than that of non treated rats. The hypoglycemic effect of the same dose of insulin is less important in the normal dog after chronic pretreatment with phenformin. | 145,295 | [
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[Ultrastructural localization of neurohypophyseal hormones and their carrier proteins by the "triple bridge" immunoenzymatic technique]. | High specific antibodies have permitted the ultrastructural localization of vasopressin, ocytocin and neurophysins 1 and 2. Hormones and carrier proteins are detected in neurosecretory granules of the hypothalamic and neurohypophyseal fibres and so at the granular and extra-granular level of supra-optic pericaryons. | 145,302 | [
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Chylothorax in two mongoloid infants. | Two newborns with stigmata of Down syndrome required resuscitation at birth because of unilateral congenital chylous pleural effusion. After thoracentesis, ventilation was improved. Congenital chylous pleural effusion in newborns with Down syndrome has not previously been described. Pleural effusion at birth must be promptly diagnosed and aspirated. | 145,331 | [
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Chromate dermatitis from a boiler lining. | Chromate dermatitis is described in a mechanical fitter working inside boiler combustion chambers. A source of hexavalent chromate is traced to the action of the heat and alkaline fuel ash on trivalent chrome ore in parts of the refractory lining. Removal of the patient from this contact has resulted in almost complete clearing of his dermatitis, without any relapse, during a 9-month follow-up period. | 145,337 | [
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[Percutaneous caffeine poisoning (author's transl)]. | In a 23-year-old patient with psoriatic erythrodermia external application of about 30g of caffeine in anhydrous eucerine led to caffeine poisoning. | 145,362 | [
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Pancreatic beta cell toxicity by streptozotocin anomers. | D-glucose in the pyranose (ring) form exists as two anomers. The alpha-anomer is more effective than the beta-anomer in promoting insulin secretion, suppressing that of glucagon, and protecting beta-cells against alloxan toxicity. Streptozotocin (SZ), a beta cell toxin, is composed of a cytotoxic moiety, 1-methyl 1-nitrosourea, attached to carbon-2 of glucose and exists as either of two anomers in the pyranose form. In 24-hour-fasted male rats, predominantly alpha- or predominantly beta-SZ was injected intravenously and plasma glucose levels were obtained 48 hours later. The alpha-anomer produced significantly greater beta-cell necrosis at doses of 30, 35, and 40 mg./kg. body weight. At higher doses, no differences between the alpha and beta anomers were observed. 3-O-Methyl glucose (3-OMG) protected against both SZ anomers; however, the alpha-SZ remained more toxic. Larger doses of glucose protected against the lower doses of SZ and, under such conditions, the individual glucose anomers appeared equally potent. Finally, mannitol at comparable molar concentrations was ineffective in protecting against the SZ toxicity. This study suggests that streptozotocin's beta cell toxicity is mediated through recognition by the beta cell. In addition, 3-OMG and, to a lesser but significant extent, glucose were shown to protect against the streptozotocin toxicity, whereas mannitol did not. | 145,386 | [
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Contribution to the biochemical characterization of cardiac glycosides concerning their influence on ATP-ases. | 1. A comparison of the complex binding constants of different glycosides show no significant differences between these different glycosides at least not in the model containing ATP. 2. There are greater differences regarding the ATP-ase activity of the different glycoside complexes measured by means of the Rb-transport method. 3. The absorption of different proscillaridin and methylproscillaridin preparations was investigated with this method. 4. Using the rat as experimental animal the effect of different glycosides on the Na-K and Ca ATP-ase of the heart muscle was demonstrated showing a remarkable activation of the Ca-activated ATP-ase caused by proscillaridin. In order to find an explanation for the therapeutic and toxic effects these investigations have to be repeated in the pig, which shows more similarities in the ATP-ase distribution to man than the rat. | 145,417 | [
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0.3632686,
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... |
The effect of synthetic gestagens on progesterone formation in vitro in human placenta of early pregnancy. | Villous tissue from 26 placentae of 7-17 weeks was incubated with radioactive pregnenolone alone and with pregnenolone in the presence of progesterone and 9 synthetic gestagenic steroids and the progesterone formation was measured after 30 min. When progesterone was present in a concentration of 31 or 310 mumol/1 the conversion rate of labelled pregnenolone to progesterone was reduced to 88.6 and 82.2% of that of the respective control incubations. Dydrogesterone, allyloestrenol, lynoestrenol and norethynodrel under similar conditions did not inhibit the formation of progesterone. The inhibitory effects of megoestrol acetate, medroxyprogesterone acetate and norgestrel were close to that of progesterone. Norethisterone and methyloestrenolone were the most effective inhibitors of progesterone formation: when incubated in an equimolar concentration (35 mumol/1) with pregnenolone (50 microgram) the progesterone formation was reduced to 60.0-62.7% and 29.1-34.0% respectively of that of the respective control experiments. | 145,492 | [
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DNA replication in bacteriophage-infected Staphylococcus aureus. | The synthesis of viral and host DNA in phage-infected Staphylococcus aureus was examined. Three intracellular forms of phage 52HJD DNA were demonstrated: covalently closed circular, open circular, and linear DNA species. It was noted that infection of S. aureus-propagating strains 81 and 52 with phage 52HJD inhibited the replication of the bacterial chromosome and a stringently controlled penicillinase plasmid. A small tetracycline plasmid, normally under relaxed replication control, continued to replicate in the postinfection period. No breakdown of the host chromosome into small-molecular-weight fragments or utilization of bacterial DNA material for the synthesis of viral DNA was observed. | 145,499 | [
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Increased atrial contribution to ventricular filling in ischemic heart disease. Non-invasive measurement by ECG-gated radiocardiography. | 1. A total of 112 subjects, including 37 controls, 43 hypertensives, 27 IHD and 5 HCM, were tested by routine RCG and ECG gated RCG. 2. The atrial contribution to ventricualar filling (c/b ratio) was measured by ECG-gated RCG and a characteristic increase was found in IHD (37.5 +/- 7.7, mean +/- s.d.) and Hypertensives (26.5 +/- 8.0) compared to controls (16.1 +/- 5.0). 3. The increase in c/b ratio and the decrease in PDdV/dt in IHD seemed to be caused by primary abnormalities in the relaxation of the ventricle. 4. ECG-gated RCG, being non-invasive method, serves useful informations in estimating ischemic heart disease especially by a quantitative analysis of the diastolic filling. | 145,500 | [
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[On the ligation of Stenon's duct in chronic-recurrent parotitis (author's transl)]. | Ligation of Stenon's duct represents a possibility for treatment of chronic-recurrent parotitis. This procedure leads to an atrophy of the gland parenchyma. In one case, observed by us as a complication of this method ligation of the duct was followed by the formation of a great parotid gland cyst. Under respect of this casuistic report, possibilities are discussed to prevent similar and other complications. They consist in the section of the preganglionic fibers of the tympanic plexus respectively in a simultaneous radiation therapy of the diseased gland. | 145,526 | [
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[Distribution characteristics of Leishmania tropica major strains of differing virulence in natural and territorial complexes of the Murgab eco-area (southeastern Turkmenistan)]. | In September--October of 1973 and 1974 263 specimens of Rhombomys opimus were shot in the territory of the Murghab stationar. The seeding of the material (a piece of tissue) from all animals into NNN medium was done. 9 strains of L. tropica major were isolated from this material the virulence of which was studied on 2.5--3 months--old golden hamsters, Cricetus auratus. Differences in the virulence of the isolated strains according to their natural-territorial complexes are shown. These differences depend apparently on the specific composition of the vectors. It is shown that the specific composition of sand flies as well as other epizootical characters are determined by the landscape of the territory where nidi of zoonosis cutaneous leishmaniasis are situated. | 145,568 | [
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[Phenology of sandflies of the subspecies Paraphlebotomus inhabiting the burrow of the great gerbil in the Karshi Steppe]. | Oberservations were conducted (1960 to 1973) on the sand flies of the subgenus Paraphlebotomus inhabiting the burrows of Rhombomys opimus in the Karshinskaya steppe (Uzbekistan). Ph. mongolensis is most abundant in oasis, Ph. caucasicus--in loess low-mountain areas. Throughout the territory investigated Ph. mongolensis has two generations per season. The emergence of imago of this species in oasis begins early in May with the first peak of abundance at the end of May--beginning of June and with the second peak in the first decade of August. The flight of Ph. mongolensis ceases in general to the middle of September. In the northern part of the territory investigated Ph. caucasicus has two mass generations with peaks in the second decade of June--first-second decade of August. In the southern part of the territory three peaks of abundance of ph. caucasicus were noted: in the middle of May, end of June--beginning of July and the end of August--beginning of September. Therefore, the presence of three generations per season can be suggested here. | 145,567 | [
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[Microsporidians (Protozoa, Microsporidia) of lower crustaceans from the reservoirs of Leningrad Province]. | 18 species of microsporidians were found in crustaceans of the Leningrad region. Of them 6 are referred to known species, 7 are described as new ones and 5 are identified to the genus. Some preliminary data are given on the influence of microsporidians on the host population, their specificity and variability. | 145,569 | [
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The results of non-operative management of stiff joints in the hand. | We selected 500 patients randomly from a total of 1300 patients seen in our Hand Rehabilitation Center between 1971 and 1975; 212 of the 500 presented with a chief complaint of stiff hand joints. Of the 212 patients treated non-operatively, 173 responded sufficiently to this treatment alone. Of the 789 stiff joints, 686 responded sufficiently to this treatment alone. The results of this regime of non-operative treatment of stiff joints provide excellent functional improvement in most patients, with a large saving of money through the reduction in disability payments required. | 145,602 | [
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Effect of acetaldehyde on functioning of cardiac muscle at the ultrastructural level. | The effect of acetaldehyde, the hepatic metabolite of alcohol, on the functioning of cardiac muscle was investigated at the subcellular level. Concentrations of acetaldehyde that occur in plasma failed to alter either the microsomal Ca2+-accumulating and ATPase activity or the Ca2+-accumulating activity of the mitochondria. These same concentrations of acetaldehyde inhibited the Ca2+-dependent myofibrillar ATPase. | 145,633 | [
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Characterization of myosin from patients with asymmetric septal hypertrophy. | Human cardiac myosin isolated from operatively obtained samples of ventricular septum and left ventricular free wall of patients with asymmetric septal hypertrophy (ASH) was compared, with respect to structural and enzymatic properties, to myosin isolated from hearts of patients without heart disease. The following parameters were studied: 1) activation of myosin ATPase activity by K+-EDTA and Ca2+,2) molecular weight of the heavy and light chains of myosin as determined by electrophoretic migration in SDS-polyacrylamide gels, and 3) ability to form bipolar aggregates at low ionic strength, as examined by electron microscopy. No difference was present in any of these parameters between human cardiac myosin from patients with ASH and from patients without heart disease. Thus, the genetic defect present in patients with ASH is not expressed in the particular structural and functional characteristics of myosin evaluated in this study. | 145,640 | [
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Increased protein synthesis during right ventricular hypertrophy following pulmonary stenosis in the dog. | The synthesis rates of mixed protein in the left and right ventricles were the same in normal dogs, averaging 7.8% per day. After five days, pulmonary stenosis protein synthesis rate in the right ventricle increased rapidly to 13.6% per day and subsequently decreased to near normal by 12 days, during which time the right ventricle protein mass increased by 48% after five days and by 73% after 12 days. Similarly the synthesis rate of the myofibrillar and sarcoplasmic proteins was almost doubled after five days of stenosis. The protein synthesis rate in the left ventricle did not change significantly during the 24 days of pulmonary stenosis. | 145,641 | [
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Necrotizing lymphadenitis: possible acute toxoplasmic infection. | A rapid rise in serum hemagglutination antibody (HA) titers for toxoplasma was detected about 2 months after the onset of cervical lymphadenopathy in two patients with necrotizing lymphadenitis. These lymph nodes proliferation of histiocytes with nuclear debris, phagocytized macrophages and necrotic areas, and the association suggested that necrotizing lymphadenitis might be caused by acute toxoplasmic infection. | 145,720 | [
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Giant cell tumor of bone: fine structural localization of acid phosphatase. | The fine structural localization of acid phosphatase in the different cells in a benign giant cell tumor of bone has been studied. Stromal cells type 1 and 2 (fibroblast-like and macrophage-like, respectively) showed the presence of lead phosphate precipitate following incubation in a Gomori-type lead salt medium only in conventional lysosomes. In the multinucleated giant cells, the final product was deposited over lysosome-like organelles, and also over Golgi cisternae, vesicles, and vacuoles. Furthermore, evidence for presence of acid phosphatase was obtained in smooth-surfaced tubular, sausage-, horse-shoe-, and ring-shaped structures and over digestive vacuoles of autophagic or heterophagic origin. Finally, in these cells, many of the tubular and vacuolar elements located subjacent to areas of the plasma membrane with microvillous specializations (abortive brush borders?) were shown to carry acid phosphatase. | 145,723 | [
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Transplacental effects of nitrosamines in Syrian hamsters. III. Dimethyl- and dipropylnitrosamine. | The aliphatic nitrosamines dimethylnitrosamine (DMN), diethylnitrosamine (DEN), dipropylnitrosamine (DPN), and dibutylnitrosamine (DBN) reached fetal tissue in quantitatively measurable amounts after subcutaneous administration to pregnant Syrian hamsters. The compounds were present for at least 2 h in maternal blood, placenta, fetus, and amniotic fluid; DBN was still measurable after 6 h. Only a weak or borderline transplacental effect was seen when incidences and latencies of neoplasms in the respiratory and digestive tracts of the F1-generation were compared with those of the P-generation after exposure to a single dose of DMN or DPN. However, some tumor types occurred at relatively high rates in the young, but were seen only occcasionally in their mothers or in this hamster colony in general. | 145,751 | [
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[The carrier potential of liposomes for methotrexate. Changing of the tissue levels of methotrexate in the organs of mice (author's transl)]. | Drugs entrapped in liposomes (artificial lipid vesicles) exhibit different pharmacokinetics after intravenous application than drugs injected in a free form. The folidacidantagonist methotrexate can be entrapped in liposomes in a therapeutically useful concentration (0.5 mg MTX/ml) and can be stored with high stability of entrappment. After intravenous injection into the tail vein of mice liposomes entrapped methotrexate is found more enriched in cell systems with high rate of endocytosis and not eliminated by the kidneys within 3 h like free methotrexate. It can be shown, that for the organs liver, spleen, kidney, gut, lung, and blood over a 6 h period liposomes entrapped methotrexate is enriched in the tissues and that for example after 6 h the methotrexate level in the liver is 20 fold higher in comparison to free injected methotrexate. | 145,758 | [
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[The influence of the type of monofilament suture on re-epithelialisation of corneal grafts (author's transl)]. | We have investigated whether a correlation exists between the quality of graft epithelialisation and three types of suture: triangular sutures, continuous and interrupted sutures. The study concerns 192 randomly chosen keratoplasties, performed by the same surgeon using suture material of 9 or 10/0 monofilament. We used the chi2 test for statistical analysis. No correlation was found to exist between the quality of epithelialisation and the type of sutures. By contrast the aetiology of the corneal disease had a highly significant influence (alpha at 1%) on the quality of this epithelialisation, with this correlation persisting whatever type of suturing was used. | 145,845 | [
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Tentoxin. An uncompetitive inhibitor of lettuce chloroplast coupling factor 1. | The interaction of tentoxin [cyclo-(-L-leucyl-N-methyl-(Z)-dehydrophenylalanyl-glycyl-N-methyl-L-alanyl-)] with solubilized lettuce chloroplast coupling factor 1 was characterized by direct binding studies, measurement of the time course of ATPase inhibition, and steady-state enzyme kinetics. Neither substrates, products or Ca2+ competed with the tentoxin binding site, nor did they induce any large change in tentoxin affinity. The inhibition of lettuce chloroplast coupling factor 1 ATPase was found to be the time dependent, and at equilibrium the affinities estimated by equilibrium ultrafiltration and enzyme inhibition were similar (1.8 . 10(8) M-1). The steady-state kinetics best fit an uncompetitive pattern suggesting that the inhibited steps follow an irreversible step occurring after ATP binding. | 145,874 | [
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Light and electron microscopy study on urethral regeneration. | In a series of experiments on dogs, it was feasible to replace a segment of urethra using wide-mesh Dacron. Light and electron microscopy study on the regenerated urethra showed no evidence of muscle, cavernous tissue and nerve regeneration. Although an excess of fibrous tissue surrounded the regenerated urethra, there was no change in the calibre of the new urethra after 7 months' observation. | 145,885 | [
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0.2075564,... |
Possible role of intestinal alkaline phosphatase activity in thiamine transport. | Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++-and (Na+ + K+)-ATPase activities did not change after the administration of ethanol. These findings show that the al-Pase activity, unlike the Ca++-ATPase activity, is not related to Ca++-absorption. A possible role of al-Pase activity in the active transport of thiamine in the intestine was discussed. | 145,948 | [
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A histochemical study of fibrinolytic activity and inhibition of plasmin in the lungs of some animal species. | Determined by the histochemical fibrin slide technique, the fibrinolytic activity of lungs decreased in the following order of species: rat, mouse, pig, guinea pig, rabbit, cattle. Examined by the fibrin slide 'sandwich' technique, inhibition of plasmin showed the opposite mode of decrease. The possible role of these differences in the pathogenesis of various disorders of the lungs in the different species is discussed. | 145,993 | [
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[The diagnostic value of mammography during pregnancy and lactation (the radiological features of the breast during pregnancy) (author's transl)]. | During early and late pregnancy and lactation, there is an increase in the size of the breasts, with increased density of their structure. The moderately dense parenchyma in young women is characterised by a) wavy contours of the subcutaneous zone and b) linear or oval translucencies in the central parenchyma. Our investigations indicate that it usually takes three months after delivery before the breast structure returns to normal and one is able to interpret the mammogram satisfactorily. For this reason mammography should be avoided during these three months and if there is a suspicion of disease in the breast, a biopsy should be carried out immediately. | 146,000 | [
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... |
Induction of specific unresponsiveness against the C3H M1s=antigen in mice, increase of suppressive capacity of C3H X CBA F1-lymphocytes after sensitization against CBA lymphoid cells. | Injection of adult CBA mice with lymphocytes from C3H X CBA donors leads to a specific reduction of the MLC reactivity of the recipients' lymphocytes. This effect is mediated by a population of F1-lymphocytes which do not seem to possess the relevant MLC-stimulatory M1s-antigen. In this investigation we have shown that injection of C3H X CBA mice with CBA, but not C3H spleen cells enhances the 'tolerogenic' capacity of their thymocytes and lymph node cells. A similar enhancing effect was achieved by 'educating' C3H X CBA lymphocytes in irradiated CBA, but not C3H hosts. The results indicate that C3H X CBA lymphocytes reduce the MLC-reactivity by reacting immunologically against CBA T-cells which possess recognition structures for the relevant M1s antigen. Lymphocytes of C3H X CBA mice can be sensitized against such recognition structures which thus renders them more 'tolerogenic'. | 146,023 | [
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Colicins and bacterial membranes: structures and functions. II. Studies on reconstituted homologous and hybrid membranes prepared from cytoplasmic membranes of untreated and colicin K-treated bacteria. | Cytoplasmic membranes of Escherichia coli K12 C600 treated and not treated with colicin K were dissociated into unsolubilized and solubilized fractions. Neither fraction catalyzed ATP-linked transhydrogenase activity. Mixtures of unsolubilized fractions of the untreated bacteria with solubilized fractions of either the treated or untreated bacteria yielded reconstituted membranes with restored ATP-linked transhydrogenase activity. The level of the activity was similar to that of the undissociated membranes of untreated bacteria. The membranes which were reconstituted from unsolubilized fractions of the treated bacteria and the solubilized fraction of the treated or the untreated bacteria showed impairment of activity. The impairment is not due to an inability to bind ATPase of the soluble fraction or to an incorrect binding of the ATPase. The impaired, reconstituted membranes showed striking decreases in the relative amounts of three proteins with apparent molecular weights of 122,000, 73,000, and 62,000. The affected proteins were found to be components of the unsolubilized membrane fraction. It is, thus, concluded that the impaired activity is due to the defective nature of the unsolubilized membrane fraction of colicin-treated cells. | 146,040 | [
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Effect of thymosin on T-lymphocyte functions in patients with acute thermal burns. | Patients with severe thermal burns demonstrate a decreased cellular immunity. The purpose of this study was to ascertain whether thymosin enhances in vitro T-lymphocyte functions in such patients. Peripheral blood lymphocytes were obtained serially from 22 burned patients and 35 health adults. In vitro lymphocyte functions were evaluated by E-rosette formation, lymphocyte culture responses to PHA, Con A, PWM, PPD, SK-SD, mumps antigen, and tetanus toxoid, and mixed lymphocyte culture reactions. These tests were performed with and without in vitro addition of thymosin. Most of the parameters examined were significantly decreased in patients during the first 2 weeks postburn. The in vitro addition of thymosin significantly restored impaired lymphocyte responses, except in mixed lymphocyte culture reactions. These results demonstrate that thymosin enhances certain in vitro T-lymphocyte functions in burned patients. They further suggest that the administration of thymosin may restore decreased cell-mediated immunity in severely burned patients. | 146,096 | [
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Nucleotide sequence of Neurospora crassa cytoplasmic initiator tRNA. | Initiator methionine tRNA from the cytoplasm of Neurospora crassa has been purified and sequenced. The sequence is: pAGCUGCAUm1GGCGCAGCGGAAGCGCM22GCY*GGGCUCAUt6AACCCGGAGm7GU (or D) - CACUCGAUCGm1AAACGAG*UUGCAGCUACCAOH. Similar to initiator tRNAs from the cytoplasm of other eukaryotes, this tRNA also contains the sequence -AUCG- instead of the usual -TphiCG (or A)- found in loop IV of other tRNAs. The sequence of the N. crassa cytoplasmic initiator tRNA is quite different from that of the corresponding mitochondrial initiator tRNA. Comparison of the sequence of N. crassa cytoplasmic initiator tRNA to those of yeast, wheat germ and vertebrate cytoplasmic initiator tRNA indicates that the sequences of the two fungal tRNAs are no more similar to each other than they are to those of other initiator tRNAs. | 146,192 | [
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Use of a new simple device, the airflometer, in detecting changes in airways obstuction. | A simple device for measuring ventilatory function, the airflowmeter, was found to be at least as sensitive as the Wright peak-flow meter in detecting histamine-induced bronchoconstriction in asthmatic patients. The apparatus also was found suitable for monitoring ventilatory function by the patients themselves at home. | 146,254 | [
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[Chordomas. Excision of a lumbar chordoma: 2 1/2 years survival without signs of recurrence and without functional complications]. | In connection with surgical removal of a chordoma in the lumbar region by large excision, followed by 31-month survival of the patient without complications, personal experience of 8 chordomas operated on over the last 20 years is reported. The authors believe their observations show the value of active surgical treatment combined with radiotherapy, which has a palliative effect on the pain and slows the evolution of the tumor. The effectiveness of surgical treatment and radiotherapy leads the authors to challenge the negative attitude generally taken towards the treatment of this condition and to adopt a position of moderate optimism. | 146,255 | [
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Experimental induction of melanotic tumors in syrian golden hamsters by transplacental and topical application of ethylnitrosourea. | Pregnant Syrian golden hamsters were treated with a single intra-peritoneal injection of ethylnitrosourea (ENU) solution a few hours pre-parturition. Offspring either received no further treatment or from 6 weeks of age, bi-weekly application of ENU solution in acetone for 20 consecutive weeks. Progeny from non, transplacentally treated mothers were also treated topically. Among all treated groups, 8.6% of the animals developed pigmented skin tumors, most of these animals having received the combined treatment. This group also showed a significantly decreased latency period in females compared to males. One of the skin tumors, which was histologically and clinically benign, was transplanted several times and subsequently exhibited malignant features. | 146,325 | [
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Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine. | Two 8-month-old and two 4-month-old male beagle dogs received 250 ml of 150 microgram/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and 2% Tween 60 mixed with a pellet diet twice a day for 8 months as the same methods used for mongrel dogs in our first report [Juntendo Medical Jouranl 19, 579-583 (1973)]. Gastric carcinomas with distant lymph nodes metastases occurred in three beagle dogs except for one died from anesthesia at the endoscopy. Metastases to the liver were observed in two beagles. In the most long-lived beagles, peritonitis carcinomatosa with ascites and metastases to the liver, lungs, bones, and skin were found. Main gastric tumors were located at the subcardia in two dogs (elevated tumor in dog No. 6, ulcerated tumor in dog No. 8), but in dog No 7 at the angulus (ulcerated tumor). Histologically, carcinomas were composed of poorly differentiated adenocarcinoma, signet-ring cell carcinoma, tubular adenocarcinoma, and undifferentiated adenocarcinoma. In all of three dogs which developed adenocarcinoma of the stomach, Stewart's criteria were completely satisifed. Using our methods the target organ is limited only to the stomach, without any sarcomatous lesion of the intestines. | 146,326 | [
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[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)]. | The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found. | 146,342 | [
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The quantitative determination of metabolites of 6-mercaptopurine in biological materials. IV. An improved separation method for twentytwo compounds related to purine and 6-thiopurine metabolism using high-pressure liquid cation-exchange chromatography. | An improved method is described for the separation of 22 compounds normally related to purine and 6-thiopurine metabolism in biological materials using high-pressure liquid cation-exchange chromatography on strongly acidic exchange resin. The column (0.8 X 100 cm) is eluted with 0.4 M ammonium formate, pH 4.6, at a linear flow velocity of 5.2 cm.min--1 at 50 degrees C. The elution volumes of sulphate anions, allopurinol, 6-thioxanthine, adenine, adenosine, and guanosine are demonstrated additionally to further 16 purine and 6-thiopurine compounds. | 146,352 | [
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Prerequisites for tuboplasty. | Techniques in measuring tubal patency and interpretation of findings can be misleading. Laparoscopic study of infertile women with suspected, diseased fallopian tubes is always prerequisite to tuboplasty. Observations must be accompanied by intrauterine injection of adequate amounts of dye and gentle tubal manipulations. Determined efforts should be made to eliminate reconstructive operations on nonsalvageable tubes because successful term pregnancies following tuboplasties are related more to the extent of tubal damage than to operative technique or postoperative management. | 146,392 | [
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Role of hydrophobic interaction in hapten-antibody binding. | The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more than -5.8 Kcal/mol to the free energy of binding. This value was consistent with the free energy change expected from the transfer of n-butane from an aqueous environment to liquid n-butane. The observed contribution was explained, in terms of the hydrophobic interaction of the isobutyl group with the antigen binding site of the antibody molecule. These results were also compared with other hapten-antibody systems. | 146,401 | [
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[Allergic contact eczema and vitiliginous depigmentations caused by paratertiary butylphenol]. | Allergic contact eczema and vitiliginous depigmentations caused by paratertiary butylphenol. In a case of allergic contact eczemas due to an occupational contact with paratertiary butylphenol, vitiliginous depigmentations appeared after a latency period of several years. Disorders of cellular immune reactions, struma and hepatosis were absent. Paratertiary butylphenol might have been absorbed by the epidermis. It is suggested for prophylactic purposes to declare the components of adhesives in order to avoid occupational contacts with dangerous substances. | 146,480 | [
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[A deep colored antimony compound from dehydroepiandrosterone (3beta-hydroxy-5-androstene-17-one). 79. Steroids and Sterines]. | Heating of dehydroepiandrosterone under nitrogen with a concentrated solution of SbCl3 in C6H5COCl (3 h at 90 degrees C) leads to a dark violet-coloured crystalline product of the composition C38H46Cl7O2Sb2 with antomony in a trivalent state. Treatment with hydrochloric acid yields an antomony-free brown-coloured product of the composition C38H40O2 with a molecular weight of 530 +/- 10%. Upon catalytic hydrogenation, it binds 6 moles of H2, yielding a yellow crystalline material which reacts already at room temperature with dilute SbCl3 to a bluish-violet solution. The structure of the substances in question is discussed. | 146,499 | [
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Gaps in DNA induced by neocarzinostatin bear 3'- and 5'-phosphoryl termini. | Neocarzionstatin (NCS)-induced strand breakage of DNA generates nonfunctional binding sites for the E. coli DNA polymerase I. Treatment of the NCS-nicked DNA with alkaline phosphatase at 65 degrees C prior to the polymerase reaction results in 60-100-fold stimulation of dTMP incorporation whereas in a control not treated with the drug there is only a 2-fold increase. Sites of strand scission on the NCS-treated DNA bear phosphate at the 3' termini. This conclusion is supported by the kinetics of release of inorganic phosphate from NCS-cut DNA by exonuclease III. Since our earlier work has shown that virtually all the 5' ends of the nicks caused by NCS bear phosphomonoester groupings, the 3'- and 5'- phosphoryl termini could be quantitated using alkaline phosphatase and exonuclease III. Over a wide range of drug levels the amount of inorganic phosphate released by alkaline phosphatase is approximately twice as much as that removed by exonuclease III, indicating the presence of equal amounts of 3'- and 5'- phosphoryl termini. This, taken together with other previously demonstrated effects of NCS on DNA, such as the introduction of nicks not sealable by polynucleotide ligase, the release of thymine, and the formation of a malonaldehyde type compound, suggests that NCS-induced strand breakage involves base release accompanied by opening of the sugar ring with destruction of one or more nucleosides and results in a gap bounded by 3'- and 5'- phosphoryl termini. | 146,515 | [
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[Experimental endoparasitism of Trypanosoma brucei in Blabera fusca: parasite survival and hemoglobin toxicity]. | Attempts for infestation of the cockroach, Blabera fusca, by Trypanosoma brucei directly inoculated in the insect's haemocoele allowed to prove the obligation of the presence of red cells in the cockroach for the survival of the flagellates, in variable assessment. These free and moving trypanosomes may be studied in the haemolymph by an original in vivo observation technic; they have few pathogenic effect on the insect but remain infectious for mice. Moreover, haemoglobin shows a direct toxic effect in the cockroach, which enlarges by destroying red cells after encapsulation by haemocytes. | 146,541 | [
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[Mutagenicity of the metabolites of the epoxide-diol pathway of safrole and its analogs. Study on Salmonella typhimurium]. | Mutagenicity of the metabolites of the expoxide-diol pathway of safrole and analogues was studied on Ames' strains with Ames' method. Safrole, eugenol, eugenolmethylether, estragol, allylbenzene and 1'-hydroxysafrole, are not mutagen on TA 1535, TA 100 (point mutation) and TA 1537, TA 1538, TA 98 (frameshift mutations) without activation system. The corresponding epoxides that we have synthetized, are mutagens and inducers of point mutation in TA 1535 and TA 100. Dose-effect curves show differences between the mutagen efficiencies of these epoxides probably in relation with their electrophilic properties. On the other hand the 2', 3'-dihydro-2',3'-dihydroxisafrole was not mutagen in Ames' test. These results confirm the promutagen character of safrole and analogues and the role of the epoxides as proximate carcinogens. | 146,546 | [
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[In vitro effects of aminoglycosides and cephalosporins on rat kidney lysosomes]. | The study of aminoglycoside and cephalosporin antibiotics was performed using a subcellular system in vitro. Lysosomes were purified from rat kidney tissue homogenates by a linear sucrose gradient centrifugation technique. The lysosomal membrane integrity was estimated by measuring the free N-acetyl-beta-D-glycosiminidase activity in the incubation medium. A scale of toxicity was established for eleven aminoglycosides and four cephalosporins. | 146,551 | [
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[Variations in the effect of clonidine on arterial pressure in rats in the presence of various anesthetics]. | The central hypotensive agent, clonidine (30 microgram/kg i.v.) has been injected in normotensive rats anesthetized with various agents. This dose of clonidine elicits usually a biphasic blood pressure response, i.e. a transient increase due to peripheral vasoconstriction, followed by a long lasting decrease. This has been observed in the animals anesthetized with pentobarbitone as well as with urethane. The hypotensive effect is abolished during chloralose, ketamine or Alfatésine anesthesia. These data emphasize that some anesthetics mays particularly modify the effects of centrally acting cardiovascular drugs. | 146,557 | [
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A cytogenetic survey of an institution for the mentally retarded: I. Chromosome abnormalities. | A cytogenetic survey of 475 patients in an institution for the mentally retarded is reported. The chromosomes of all patients were studied using both a non-banding and a G-banding technique in order to estimate the relative efficiency of the two technique in detecting structural rearrangements of the chromosomes. A total of 57 patients was found to have a chromosome abnormality, including five with a balanced structural rearrangement. The contribution of chromosome aberrations to the etiology of mental retardation is discussed with special emphasis on the contribution of balanced structural rearrangements. | 146,575 | [
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Observations of ridge appearances in a normal population and in Down syndrome patients (21-trisomy) using the scanning electron microscope. | A celluloid plate containing a drop of amyl acetate was pressed to the skin. The impression thus obtained was coated with carbon and gold and observed under the scanning electron microscope. Impressions from the fingers of the normal population showed the crests and furrows of the finger prints clearly. The impressions from the fingers of Down syndrome patients were a mixture of the normal crests and furrows and of hypoplastic crests and furrows. | 146,576 | [
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-0.2096221,
-0.0669935,
-0.1622038,
-0.1916113,
0.4102619,
0.3165407,
-0.1285097,
-0.2... |
Low-dose minocycline therapy in tetracycline-recalcitrant acne vulgaris. | Ninety-one patients with acne vulgaris were selected for a two-part study primarily because the severity of disease suggested that it might be tetracycline-recalcitrant. Of the eighty-eight patients completing the first part of the study, thirty-two were judged to have tetracycline-nonresponsive acne and received 50 mg of minocycline twice daily for the next six to eight weeks. Twenty-five patients completed this second part of the study. Of these twenty-five, twenty-two experienced a 33 percent or greater reduction in the number of lesions. It is concluded that minocycline in a dosage of 50 mg twice daily is a safe and effective antibiotic for those patients with tetracycline-recalcitrant acne vulgaris. | 146,595 | [
0.0363539,
-0.05417771,
0.07563006,
-0.1753863,
-0.2075665,
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-0.06618414,
0.1567958,
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0.1271055,
0.2330861,
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0.09921528,
0.009256334,
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0.3635241,
-0.3050454,
0.009800239,
0.07025231,
0.09653716,
0.060667... |
Measurement of testosterone and dehydroepiandrosterone 16alpha-hydroxylase activities by a tritium exchange method. | A new isotopic method, based upon the stereospecific replacement of a proton (3H) by a hydroxyl group has been developed for the measurement of rat liver testosterone and dehydroepiandrosterone 16alpha-hydroxylase activity. Specifically 16-tritiated substrates were prepared by microbiological (Cylindrocarpon radicicola) transformation of the [16-3H]progesterone and [16-3H]pregnenolone. The incubation medium consists of a phosphate buffer (pH7; 150mM), NADPH (0.1 mM), nicotinamide (10mM) and magnesium chloride (4 mM). Tween 80 (1 mg/ml) is used to solubilize saturating concentrations of [16-3H]testosterone (50 micron) or [16-3H]dehydroepiandrosterone (100 micron). The enzymatically released tritium is recovered in the incubation medium as tritiated water which is distilled under reduced pressure and counted by liquid scintillation. The method is easy to perform, very sensitive (50 pmol of 16alpha-hydroxylated metabolites) and is independent of any further metabolism of the 16alpha-hydroxylated products. | 146,601 | [
-0.2126395,
0.1127759,
-0.13815,
0.1750353,
-0.367001,
-0.4594516,
-0.102958,
0.2240388,
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0.1916023,
0.09289669,
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0.4359508,
0.1855046,
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-0.148155,
0.07531662,
-0.05585702,
0.07123382,
0.5123152,
0.0152178,
0.2202353,
0.15816... |
Evaluation of sequelae of tubal ligation. | An evaluation was made of 268 patients undergoing elective sterilization with respect to the ensuing development of menorrhagia, pelvic pain, and the need for gynecologic surgery. Preoperative and follow-up postoperative questionnaires of patients undergoing laparoscopic sterilization were compared, and additional data were drawn from clinical records and operative reports to substantiate real changes. A study of the cases puts the incidence of menorrhagia at 6%, pelvic pain at 6%, and necessary subsequent gynecologic surgery at 4%. | 146,613 | [
0.08378439,
0.09382986,
-0.06244408,
-0.1678033,
-0.3172876,
-0.2932659,
0.05854718,
-0.1012986,
0.07034047,
-0.1927774,
0.2369101,
0.09077927,
-0.05245599,
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0.06471137,
-0.2535859,
0.1531485,
-0.1449257,
-0.07050589,
0.1864326,
0.3094345,
-0.01863... |
[The normal pancreas as seen on the computerised tomogram (author's transl)]. | The normal appearances of the pancreas as seen on computerised tomograms (EMI) has been demonstrated in fifty normal patients and correlated with fifteen post mortem studies on patients with a normal pancreas. The problems of optimal demonstration of the pancreas on computerised tomograms and possible sources of error in the interpretation of transverse pancreas tomograms are discussed. | 146,653 | [
0.03771225,
-0.02447199,
0.0007313229,
-0.03127659,
0.05377642,
-0.1097505,
-0.3221311,
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0.3758649,
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0.2047557,
-0.0453805,
-0.04892598,
0.05222378,
0.07698074,
-0... |
[Computer tomographic and scintigraphic aspects of subdural haematomas (author's transl)]. | Cerebral computer tomography in cases of emergency is undoubtedly superior to conventional neuro-radiological methods. The changes during resorption of intracranial bleeds, which are due to their particular physical properties, can supply valuable diagnostic information, but under particular circumstances they may obscure the diagnosis. The diagnosis and differential diagnosis of subdural haematomas may become difficult during the isodense phase. Hyper- and hypo-dense collections of fluid may also be missed unless note is taken of subtile indirect signs and special techniques are used. At the same time, the value of cerebral scintigraphy is emphasised. Valuable information may be expected from early scans (10 to 15 minutes after injection). In this way even shallow, bilateral subdural haematomas can be demomstrated during the acute and sub-acute stage. The degree of uptake depends on the histology of the capsule of the haematoma. | 146,654 | [
-0.09628661,
0.04944816,
0.0965308,
-0.1964228,
-0.1564065,
-0.4734531,
-0.2904286,
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0.1560537,
0.01617889,
0.09997558,
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0.04053162,
0.148677,
0.1676948,
0.4569225,
0.2202116,
0.03816715,
-... |
Prosthetic materials and wound healing. Critical evaluation of six different materials. | Six different materials (three mesh and three cloth) commonly used for the repair of abdominal wall hernias were evaluated in 180 rats. Macroscopic, bacteriologic, mechanical and histologic criteria were used to investigate tolerance and resistance of the foreign material. Findings demonstrate the superiority of mesh over cloth materials. | 146,683 | [
0.01389009,
0.2303871,
-0.2440989,
-0.01023524,
-0.1242669,
-0.05044406,
-0.2147993,
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0.1888731,
0.1411416,
0.1743169,
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-0.00597633,
-0.2473903,
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-0.2114133,
-0.1222033,
-0.1994647,
0.02087803,
-0.06519929,
0.1390646,
0.1047878,... |
The canine eye: in vitro dissolution of the barriers to aqueous outflow. | Facility of aqueous outflow and time-dependent changes in its hyaluronidase-sensitive and hyaluronidase-resistant components were evaluated in freshly excised canine eyes by constant pressure quantitative aqueous perfusion. Mean baseline facility of outflow was 0.24 microliter/min/mm Hg. With prolonged perfusion at constant intraocular pressure, facility of outflow was observed to increase almost linearly for at least 3 hr and continued to increase for up to 10 hr, reaching a maximum several times the initially measured facility. Perfusion with pooled dog aqueous humor did not prevent the time-dependent increase in measured facility. Rapid exchange of anterior chamber contents with perfusion solution alone produced an immediate threefold increase in facility, again followed by a gradual time-dependent facility increase. Rapid exchange of anterior chamber contents with hyaluronidase produced an immediate fivefold increase in facility with stabilization of measured facility over 3 hr and subsequent perfusion. The time-dependent changes in measured facility of outflow or "washout phenomenon" appeared to result from the gradual dissolution of the hyaluronidase-sensitive component of the barriers to aqueous outflow in the canine eye. | 146,684 | [
-0.1307303,
-0.1829566,
-0.4648471,
-0.1605289,
0.03863356,
-0.5262048,
0.1510381,
0.03488612,
0.05409976,
-0.1881271,
0.3187529,
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0.04688041,
0.1768391,
0.02437315,
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0.1368976,
-0.1540272,
0.08335429,
-0.08669375,
0.0621204... |
Huntington's disease: improvement with an anticoagulant-psychotherapy regimen. | A 45-year old women with Huntington's disease (HD) was followed for three years while under an anticoagulant-psychotherapy regimen. The chorea disappeared and the patient improved rather than deteriorating as predicted. All psychotropic drugs were discontinued. This case of reversal of the disease may help to confirm the hypothesis that HD is probably due to circulatory insufficiency in the substantia nigra. | 146,722 | [
-0.08484167,
0.3728959,
-0.0523772,
-0.2475128,
0.2802225,
-0.243828,
-0.01258733,
-0.2205995,
-0.2992987,
-0.07588282,
0.2683282,
0.8653146,
0.03166726,
-0.018934,
0.1571537,
0.1987786,
-0.3293594,
0.2978103,
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0.1176015,
-0.05391134,
-0.08887179,
-0.105809,
... |
Fibrinolytic enzyme in the lining walls of chronic subdural hematoma. | Active plasmin, available plasmin, and total plasminogen were measured by Enzo-diffusion fibirn plate techniques in 11 cases and level of tissue activator and tissue fibrinolytic activities in another 11 cases with chronic subdural hematoma. The values were too small to be measured in some instances. Anti-plasmin in the hematoma was less than in the blood plasma. The outer membrane contained about three times more tissue activator than the dura mater, although the inner membrane contained none. Increased tissue activator, which exudes from the extremely vascular outer membrane, transforms plasminogen into plasmin in subdural hematoma, so that plasmin breaks down fibrin and fibrinogen and induces continuous hemorrhage. | 146,730 | [
-0.1699192,
-0.08021406,
0.09329992,
-0.1156027,
0.05585158,
-0.217659,
-0.1820091,
0.1943218,
0.2029996,
0.05004204,
0.02747633,
-0.03422637,
0.02838729,
0.05956703,
-0.2405186,
-0.07660048,
-0.6366956,
0.04107449,
-0.2059893,
0.2896129,
0.1347922,
-0.2010341,
-0.1336388... |
Reoperation after lumbar intervertebral disc surgery. | This retrospective study includes 53 patients who underwent reoperation after failure of lumbar disc surgery to relieve pain. All patients had leg pain before reoperation, which was successful in 28% of cases. Most clinical features, such as persistence or mode of recurrence of pain, radicular quality of pain, positive straight-leg raising, and myelographic root sleeve defects, were not helpful in predicting successful and unsuccessful reoperations. However, a significantly larger percentage of women than men had successful reoperations. Patients who had past or pending compensation claims, who had sensory loss involving more than one dermatome, or who failed to have myelographic dural sac indentations resembling those caused by a herniated disc did poorly with reoperation. A very convincing myelographic defect appears to be needed to justify reoperation at a previously unoperated location. Excision of scar alone or dorsal rhizotomy was of no avail in these cases. | 146,731 | [
0.5659605,
0.114701,
0.08736906,
-0.03318835,
0.06909738,
-0.4824105,
-0.001009994,
-0.1012391,
0.1319348,
-0.2378751,
0.142957,
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0.09773344,
0.1055533,
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0.1086842,
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0.0472884,
0.01460772,
-0.5417126,
0.02589978,
-0.07935996,
0.008312181,... |
[Intertrochanteric osteotomies. A critical study of the clinical radiologic evaluation]. | The authors describe the technique that they have used in approximately 500 intertrochanteric osteotomies of the femur. The technique was satisfactory in the production of bony union but in ten per cent of cases there were errors of correction of 5 degrees or more. An analysis of errors related to the radiological technique used showed that a number of conditions (flexion, abduction) modify the angles of inclination and anteversion. A number of instances of degenerative arthritis had been incorrectly attributed to increased coxa valga. An analysis is made of the difficulties encountered when correction is required in two planes, especially when there is fixed flexion or significant anteversion. Some suggestions are made concerning improvements in technique. | 146,887 | [
-0.008492751,
0.1397007,
-0.1028495,
0.02136337,
-0.07186452,
-0.1699185,
-0.2431206,
0.1086213,
-0.05956851,
-0.06080576,
0.1459311,
-0.2595194,
-0.1428324,
-0.3857927,
-0.4725359,
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-0.08678594,
0.3348113,
-0.1298333,
0.5124377,
0.2535312,
-0.07221984,
-0.0165... |
[Attitude of the paralytic supination of the forearm in children. Surgical treatment in 19 cases]. | Nineteen cases of paralytic supination contracture have been surgically treated in children and teenagers. Three successive stages are described - 1) reducible deformity 2) contractures of soft tissues and 3) skeletal deformities. Surgical treatment aimed to improve the patient cosmetically and functionally. Ideally, the condition should be corrected early, during the first stage. The results of the Zancolli procedure of section of the interosseous membrane and rerouteing of the biceps in 11 cases were all satisfactory. Osteotomy of one or both bones could be used in association in cases with fixed deformity. | 146,889 | [
0.07451053,
-0.1673329,
0.3232198,
-0.1254409,
0.1178948,
-0.1878567,
-0.5569036,
-0.04971198,
0.0732198,
0.1653657,
0.136462,
-0.0977253,
-0.06742922,
0.09579936,
-0.02465002,
-0.3481685,
-0.01225718,
-0.07246107,
-0.2005389,
-0.08158245,
0.4469081,
0.05927764,
-0.035479... |
Prognosis of chronic obstructive lung disease in relation to radiology and electrocardiogram. | Survival in relation to radiological and electrocardiographical changes was examined in a retrospective study of 228 hospital patients aged 40-69 years with a FEV1 of 1.5 1 or less, and a FEV1 of 70% or less of the vital capacity due to chronic obstructive lung disease. The only radiological changes which influenced survival after 4 years were enlarged heart and pronounced dilatation of the pulmonary artery. Thirty-eight percent of the patients with normal ECG but with pronounced dilatation of the pulmonary artery were alive after 4 years. In patients with normal ECG and normal or moderate dilatation of the pulmonary artery about 80% had survived after 4 years. There was only 18% survival after 4 years in patients with abnormal ECG and pronounced dilatation of the pulmonary artery and/or with enlarged heart, and only 6% in patients from age group 60-69. In patients with abnormal ECG without enlarged heart and without pronounced dilatation of the pulmonary artery 50-63% had survived after 4 years. Pulmonary hyperinflation was not important for survival during the first 4 years. | 146,913 | [
0.3656591,
-0.01020996,
-0.4024989,
-0.2285193,
-0.1193473,
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0.259217,
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-0.2531454,
0.02438288,
0.3229588,
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0.2492453,
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0.005815433,
0.438008,
0.1801301,
0.1084853,
0.2165384,
0.316424,
-0.1284558,
0.031... |
On the HLA-B,D map distance. | HLA--A,--B,--C and--d typing and intra-familial MLC studies in 21 couples and their 91 children revealed three B, D recombinants in 165 informative haplotypes. This corresponds to a B,D map distance of 1.8 centiMorgans, which is somewhat higher than previous estimates based on intra-familial MLC chessboard experiments. All three recombinants are maternal. | 146,925 | [
-0.182013,
0.1734701,
0.05714084,
0.2447109,
0.490991,
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-0.3601534,
0.07491057,
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0.04752794,
0.1157396,
0.2624641,
0.2332407,
0.2290478,
-0.6097661,
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-0.4433048,
0.01220443,
0.04582171,
0.04869993,
0.3994359,
0.2654945,
-0.2131024,
0.03... |
[ATPase activity and processes of calcium transport in membranes of sarcoplasmic reticulum of skeletal muscles with E-avitaminotic dystrophy]. | Peculiarities of functioning of the sarcoplasmic reticulum muscles membranes with E-avitaminotic distrophy were studied. It was determined that the level of ATP-dependent consumption of Ca2+, value of the Mg2+, Ca2+-ATPase activity and an amount of the intermediate phosphorylated product forming in the reaction of ATP hydrolysis decrease. The rate of this product formation in the sarcoplasmic reticulum of the distrophic muscles is inhibited as compared to normalcy. Elimination of Ca2+ into calcium-free medium from the vesicular membranes of the reticulum preliminarily loaded with Ca2+ occurs more rapidly under dystrophy than in normalcy. The data obtained evidence for a disturbance of mechanism of Ca2+ active transport and for an increase in the membrane permeability for Ca2+ in the membranes of the dystrophic muscles sarcoplasmic reticulum. A problem is considered on a dependence of the skeletal muscles observed in the reticulum under dystrophy of the functional changes on the membrane structure, in particular on their lipid composition. | 146,930 | [
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0.2390504,
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0.2538623,
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-0.2096611,
-0.1388638,
-0.02573906,
0.570569,
0.2373517,
-0.1201447... |
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