title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Isolation and purification of a small molecular weight hydroxyproline-containing structural glycopeptide from early mammalian granulation tissue. | A small molecular weight structural glycopeptide was solubilized after collagenase digestion of the connective tissue capsule surrounding the 5-day sponge-implant of the rat. The major amino acids are one residue each of aspartic and glutamic acids, proline, hydroxyproline and alanine and two residues of glycine, and t... | 144,581 | [
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[Effect of talliblastine on several hematologic indices]. | The authors carried out a study on the blood formation of healthy experimental animals after treatment with the potential antitumours agent taliblastine in view of clarifying its influence. The experiments were undertaken on inbred mice DVA/2 and rats on the Wistar strain. Taliblastine was administered intraperitonealy... | 144,597 | [
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The isolation and characterization of differentially phosphorylated fractions of phosphofructokinase from rabbit skeletal muscle. | A preparation of phosphofructokinase from rabbit skeletal muscle is described which exploits the association-dissociation properties of the enzyme. Phosphofructokinase to prepared is partially phosphorylated and may be fractioned into three distinct species with sedimentation coefficients of 30 S, 18 S and 13 S by chro... | 144,600 | [
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[Mechanism of the hypobilirubinemic action of nicofezon]. | The effect of nicophesone on the processes of cojugation and alkaline phosphatase was studied in tests staged on albino rats and rabbits poisoned with carbon tetrachloride (CCl4). Nicophesone is shown to stimulate conjugation of bilirubin with glucoronic and sulphuric acids and to depress the activity of alkaline phosp... | 144,607 | [
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[Improved scintigraphic imaging of the adrenals with 6beta-131I-iodomethyl-cholesterol (author's transl)]. | Scintigraphic visualization of the adrenals is greatly improved after substitution of 131I-19-I-Cholesterol by 6beta-131I-Iodomethyl-Cholesterol which was first seen as a radiochemical impurity during the synthesis of 131I-19-Iodocholesterol. The interpretation of the scintigraphic imaging is further improved by applic... | 144,660 | [
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[Arthrography of the hand in an accident clinic (author's transl)]. | By 115 arthrographies of the wrist in patients with posttraumatic pain, the importance of the method for diagnosis in injured patients is discussed. It was possible to detect 29 cases with a lesion of the articular disc, 4 patients with ruptured radiocarpal joint and 3 cases with an injury of the distal radioulnar join... | 144,681 | [
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[Side effect of metrizamide and meglumine iocarmate in lumbar myelography. A prospective, parallel, interview study (author's transl)]. | Side effects of metrizamide (Amipaque) and meglumine iocarmate (Dimer-X) were compared in lumbar myelography of 161 patients by a prospective, parallel, interview study. Severe complications were not observed. The percentage pairs of smaller complications were mainly in favour of Dimer-X, but in 2 of the 54 pairs only ... | 144,686 | [
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Papular mucinosis. | Most patients previously reported to have papular mucinosis had the generalized lichenoid papular form (scleromyxedema) with abnormal gamma globulin. Microscopic examination of affected skin showed increased acid mucopolysaccharides in the dermis and proliferation of fibroblasts. Our patient had the discrete form of pa... | 144,708 | [
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Some determinants of the reinforcing and punishing effects of timeout. | Some determinants of the reinforcing and punishing properties of timeout were investigated in two experiments. Experiment I began as an attempt to reduce the frequency of tantrums in a 6-yr-old autistic girl by using timeout. Unexpectedly, the result was a substantial increase in the frequency of tantrums. Using a reve... | 144,719 | [
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Inhibition of proteases in coagulation, kinin-forming and complement systems by alpha2-plasmin inhibitor. | Inhibitory activities of alpha2-plasmin inhibitor against various proteases were investigated. The inhibitor promptly inhibited the esterolytic activity of alpha-chymotrypsin and progressively inhibited the esterolytic or amidolytic activities of bovine plasma kallikrein, bovine thrombin and bovine activated factor X. ... | 144,728 | [
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Metabolism of crufomate [(4-tert-butyl-2-chlorophenyl methyl methylphosphormidate)] by the rat. | Fifteen metabolites of crufomate (4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate, I) were identified in the excreta from rats given single oral doses of I. Compound I was not detected in either the urine or the feces. The metabolic reactions observed were N-and O-demethylation, oxidations of the t-butyl moiet... | 144,748 | [
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Lack of involvement of monoamine oxidase inhibition in the lethality of acute poisoning by chlordimeform. | Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration of phenylephrine, a directly acting alpha-adrenergic agonist, with ch... | 144,803 | [
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Metabolic changes with inflammation induced by a surfactant. | Studies were carried out to determine the relationship between metabolic histopathological changes in the gastrocnemius muscle of rats in which an acute exudative inflammation had been induced by alkyldimethylbenzylammonium chloride (alkyl-DBAC, a cationic surfactant). Succinate respiration, Na+-K+-Mg2+ ATPase activity... | 144,813 | [
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[Therapy of androgenization symptoms: double blind study of an antiandrogen preparation (SH B 209 AB) against neogynon (author's transl)]. | The antiandrogen-containing preparation SH B 209 AB was tested in comparison with an ovulation inhibitor with no antiandrogenic effect (Neogynon) in a randomized, double blind study conducted to determine the effects of both on androgenization symptoms. 88 patients took part in the study. In the majority of cases the d... | 144,842 | [
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Nuclear-extranuclear interactions affecting oligomycin resistance in Aspergillus nidulans. | The extranuclear mitochondrial oligomycin-resistant mutation of Aspergillus nidulans, (oliA1), was transferred asexually into four nuclear oligomycin-resistant strains of different phenotypes. In all four cases, the possession of the nuclear plus extranuclear mutation led to an increase in the in vivo level of oligomyc... | 144,864 | [
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Differences between functional versus organic low back pain patients. | There are contradictory findings about whether there are differences in personality and/or amount of emotional disturbance between patients with functional versus organic low back pain. The MMPI scores of 42 back pain patients diagnosed as "organic" were compared with the scores of 37 patients classified as "functional... | 144,890 | [
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Migration of Escherichia coli dnaB protein on the template DNA strand as a mechanism in initiating DNA replication. | The first step in conversion of varphiX174 singlestranded DNA to the duplex replicative form in vitro is the synthesis of a nucleoprotein intermediate [Weiner, J. H., McMacken, R. & Kornberg, A. (1976) Proc. Natl. Acad. Sci. USA 73, 752-756]. We now demonstrate that dnaB protein (approximately one molecule per DNA ... | 144,914 | [
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[Simplified diagnostic scheme for Enterobacteriaceae]. | After testing 18 experimental variants against 40 reference strains belonging to different Enterovacteriaceae groups, the authors chose a multitest medium that permits concomitant testing of mobility, indol, lysinedecarboxylase and phenylalanine deaminase (MILP). In this medium, the reactions of 3734 strains belonging ... | 144,994 | [
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Distribution of water between extracellular and intracellular compartments of incised wounds of rabbits. | The distribution of water between the extracellular and intracellular compartments in incised wounds of skin, muscle and stomach has been studied in healthy rabbits and the progress of healing monitored by the determination of tensile strength for 120 days. It has been shown that, after wounding, there is an immediate ... | 145,028 | [
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[Benzoyl peroxide in the treatment of acne vulgaris (author's transl)]. | 63 patients suffering from predominantly papulo-pustular acne vulgaris were treated with 5-10% benzoyl peroxidegel over a period of 2-4 months. The skin condition showed marked improvement in 80% of the patients. Two patients developed cutaneous allergy. Benzoyl peroxide is the therapy of choice for the inflammatory fo... | 145,097 | [
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[Cellular immunity during and after high-dose methotrexate therapy in patients with osteosarcoma (author's transl)]. | Nine patients with osteogenic sarcoma and one patient with epitheloid sarcoma of bone undergoing treatment with high-dose methotrexate (MTX) therapy were studied immunologically. The following peripheral blood lymphocyte parameters were evaluated: 1-8 days after the intravenous infusion of 7.5 g MTX followed by leucovo... | 145,098 | [
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[The effect of cardiovascular hypertrophy on the work capacity of hypertensive patients]. | Hypertensive persons with pathological ECG in rest compared with healthy persons and hypertensives with normal ECG in rest show a significantly decreased physical efficiency. In hypertensives in stage II disturbances in form of references to a stress heart insufficiency, to a stress coronary insufficiency and a circula... | 145,101 | [
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Structure and anticholinesterase activity of series of ethyl substituted phenyl methylphosphonates. | Thirty derivates from substituted-phenyl-ethyl methylphosphonates have been synthesized and their inhibiting power of acetyl-cholinesterase have been examined in vitro and in vivo. The correlation between inhibition of the enzyme and electrophylic power of the substituent of the phenyl group was excellent, but when thi... | 145,115 | [
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Hydroxycinnamoyl: coenzyme A transferase involved in the biosynthesis of kaempferol-3-(p-coumaroyl triglucoside) in Pisum sativum. | The major flavonoids of Pisum are derivatives of kaempferol and quercetin, including both triglucosides and acylated triglucosides in which the acyl group is p-coumaric acid. Although hydroxycinnamic acid esters of flavonoids are common pigments in many plants, neither the enzymes nor the precursors involved in their b... | 145,116 | [
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Development of phage populations in a bacterial culture: a mathematical model. | A mathematical model for the interaction kinetic in phage-bacterium culture is proposed. An appropriate analytical relationship between phage and bacterial concentrations has been derived. Characteristic kinetic constants have been obtained by comparing the experimental growth curves with computer-simulation analysis. ... | 145,125 | [
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The activity of Golgi-membrane galactosyltransferase in the liver of streptozotocin-diabetic rats. | The Golgi-rich membrane fraction isolated from streptozotocin-diabetic rat liver had a lower protein content than the corresponding fraction from normal liver. Its UDPgalactose-N-acetylglucosamine galactosyltransferase activity calculated per 1 g of liver or whole liver was decreased. The electron-microscopic examinati... | 145,156 | [
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[Centronuclear myopathy (author's transl)]. | Three cases of centronuclear myopathy are reported in a sibship. The disease starts during the late childhood and has a very slow progressive course. Clinical examination reveals a ptosis of the eyelids, a weakness of the facial muscles, a high-arched palate and a diffuse involvement of the lower extremities. The respi... | 145,158 | [
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Normal chemotactic activity of granulocytes obtained by filtration leucapheresis. | The chemotactic activity of granulocytes obtained by the Terumo Filtration Leucapheresis System (F.L.) was examined by the method of Boyden's chamber. The number of cells migrating through the Millipore filter was expressed as the chemotactic activity. The mean values were 117 for the F.L. and 122 in a control, in whic... | 145,164 | [
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... |
[Influence on the function of lymphocytes in children with generalised mycosis during treatment with 5-fluorocytosin (author's transl)]. | After LT Tests with PHA, PPE and Candidin in mixed cultures negativ or decreased results of cellular immunoreactions were obtained in cases of generalised mycosis, taking into account age-specific variations. The generalised form of mycosis having disappeared, the findings returned to normal. While in other diseases th... | 145,175 | [
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Head Start has little to do with mental retardation: a reply to Clarke and Clarke. | Clarke and Clarke's (1977) critique of Head Start in an editorial on mental retardation is based upon questionable assumptions, a selective review of research, and errors in fact. There is considerable evidence that Head Start has improved the social competence of economically disadvantaged children. | 145,182 | [
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[A comparative study of the development of trisomy 21 concepti and the growth of their cells in vitro]. | Children with trisomy 21 are only a part of conceptuses with this anomaly which leads mainly to early arrests of development. Growth retardation of embryo and placenta are the main characteristics of these abortuses. Cell lines were established from tissues of trisomics 21 of different types of evolution (early spontan... | 145,209 | [
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... |
A double-blind study of the effect of zinc and oxytetracycline in acne vulgaris. | With a double-blind technique, the effects of oral zinc and tetracyclines were compared in 37 patients with moderate and severe acne. No difference in effect between the treatments was seen and no side-effects were noted in any group. After 12 weeks of treatment, the average decrease in the acne score was about 70% in ... | 145,237 | [
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Changes in the activities of some membrane-associated enzymes during in vivo ageing of the normal human erythrocyte. | Human erythrocytes from healthy male donors were fractionated with respect to in vivo age by simple centrifugation in order to characterize changes in the functional integrity of the membrane during the life-span of the cell. The three enzymes, Na/K-ATPase, glyceraldehyde-3-phosphate dehydrogenase and NADH-ferricyanide... | 145,240 | [
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Histology of the capsules causing constrictive fibrosis around breast implants. | Histological features seen in 9 capsules formed around breast prostheses with Dacron patches were described. Dacron evoked a marked foreign body reaction and fibroplasia. Parts of the silicone layer in which the Dacron fibres were originally anchored may also get into the capsule together with the Dacron. The main caus... | 145,256 | [
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[Plasma concentration and metabolic clearance rate of aldosterone at weaning, at puberty, and in adult guinea pigs]. | Plasma aldosterone concentrations were measured by radioimmunoassay and metabolic clearance rates (M.C.R.) were determined by a continuous infusion of H3-aldosterone on day 20 and 50 and at 3, 6 and 24 months in the male and the female guinea-pig. Plasma aldosterone concentration rose gradually from day 20 up to 24 mon... | 145,280 | [
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[Cholinesterases and arylesterase in the umbilical cord, the placenta, and the amniotic membrane, in the female at term]. | Cholinesterasic activity of umbilical cord (tissue), completely bloodless, is exclusively due to pseudocholinesterase. Cholinesterase is more active in placenta than in cord; it is an acetylcholinesterase at 80 per cent. Both forms coexist, about equally, in amniotic membrane. A considerable arylesterasic activity is p... | 145,288 | [
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[Lack of concordance in the effect of large doses of phenformin on insulin secretion and glycemia. Tentative analysis]. | In the anesthetized dog normal or pretreated with phenformin (20 mg/kg per os) for 7 days, a subcutaneous injection of this biguanide (20 mg/kg) triggers a considerable hyperinsulinemia without concomitant hypoglycemia. The insulin secreted by these animals is biologically active on rat epididymal fat pads. On the othe... | 145,295 | [
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[Ultrastructural localization of neurohypophyseal hormones and their carrier proteins by the "triple bridge" immunoenzymatic technique]. | High specific antibodies have permitted the ultrastructural localization of vasopressin, ocytocin and neurophysins 1 and 2. Hormones and carrier proteins are detected in neurosecretory granules of the hypothalamic and neurohypophyseal fibres and so at the granular and extra-granular level of supra-optic pericaryons. | 145,302 | [
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Chylothorax in two mongoloid infants. | Two newborns with stigmata of Down syndrome required resuscitation at birth because of unilateral congenital chylous pleural effusion. After thoracentesis, ventilation was improved. Congenital chylous pleural effusion in newborns with Down syndrome has not previously been described. Pleural effusion at birth must be pr... | 145,331 | [
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Chromate dermatitis from a boiler lining. | Chromate dermatitis is described in a mechanical fitter working inside boiler combustion chambers. A source of hexavalent chromate is traced to the action of the heat and alkaline fuel ash on trivalent chrome ore in parts of the refractory lining. Removal of the patient from this contact has resulted in almost complete... | 145,337 | [
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0... |
[Percutaneous caffeine poisoning (author's transl)]. | In a 23-year-old patient with psoriatic erythrodermia external application of about 30g of caffeine in anhydrous eucerine led to caffeine poisoning. | 145,362 | [
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Pancreatic beta cell toxicity by streptozotocin anomers. | D-glucose in the pyranose (ring) form exists as two anomers. The alpha-anomer is more effective than the beta-anomer in promoting insulin secretion, suppressing that of glucagon, and protecting beta-cells against alloxan toxicity. Streptozotocin (SZ), a beta cell toxin, is composed of a cytotoxic moiety, 1-methyl 1-nit... | 145,386 | [
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Contribution to the biochemical characterization of cardiac glycosides concerning their influence on ATP-ases. | 1. A comparison of the complex binding constants of different glycosides show no significant differences between these different glycosides at least not in the model containing ATP. 2. There are greater differences regarding the ATP-ase activity of the different glycoside complexes measured by means of the Rb-transport... | 145,417 | [
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The effect of synthetic gestagens on progesterone formation in vitro in human placenta of early pregnancy. | Villous tissue from 26 placentae of 7-17 weeks was incubated with radioactive pregnenolone alone and with pregnenolone in the presence of progesterone and 9 synthetic gestagenic steroids and the progesterone formation was measured after 30 min. When progesterone was present in a concentration of 31 or 310 mumol/1 the c... | 145,492 | [
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DNA replication in bacteriophage-infected Staphylococcus aureus. | The synthesis of viral and host DNA in phage-infected Staphylococcus aureus was examined. Three intracellular forms of phage 52HJD DNA were demonstrated: covalently closed circular, open circular, and linear DNA species. It was noted that infection of S. aureus-propagating strains 81 and 52 with phage 52HJD inhibited t... | 145,499 | [
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Increased atrial contribution to ventricular filling in ischemic heart disease. Non-invasive measurement by ECG-gated radiocardiography. | 1. A total of 112 subjects, including 37 controls, 43 hypertensives, 27 IHD and 5 HCM, were tested by routine RCG and ECG gated RCG. 2. The atrial contribution to ventricualar filling (c/b ratio) was measured by ECG-gated RCG and a characteristic increase was found in IHD (37.5 +/- 7.7, mean +/- s.d.) and Hypertensives... | 145,500 | [
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[On the ligation of Stenon's duct in chronic-recurrent parotitis (author's transl)]. | Ligation of Stenon's duct represents a possibility for treatment of chronic-recurrent parotitis. This procedure leads to an atrophy of the gland parenchyma. In one case, observed by us as a complication of this method ligation of the duct was followed by the formation of a great parotid gland cyst. Under respect of thi... | 145,526 | [
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[Distribution characteristics of Leishmania tropica major strains of differing virulence in natural and territorial complexes of the Murgab eco-area (southeastern Turkmenistan)]. | In September--October of 1973 and 1974 263 specimens of Rhombomys opimus were shot in the territory of the Murghab stationar. The seeding of the material (a piece of tissue) from all animals into NNN medium was done. 9 strains of L. tropica major were isolated from this material the virulence of which was studied on 2.... | 145,568 | [
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0.6081569,
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... |
[Phenology of sandflies of the subspecies Paraphlebotomus inhabiting the burrow of the great gerbil in the Karshi Steppe]. | Oberservations were conducted (1960 to 1973) on the sand flies of the subgenus Paraphlebotomus inhabiting the burrows of Rhombomys opimus in the Karshinskaya steppe (Uzbekistan). Ph. mongolensis is most abundant in oasis, Ph. caucasicus--in loess low-mountain areas. Throughout the territory investigated Ph. mongolensis... | 145,567 | [
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-0.1289156,... |
[Microsporidians (Protozoa, Microsporidia) of lower crustaceans from the reservoirs of Leningrad Province]. | 18 species of microsporidians were found in crustaceans of the Leningrad region. Of them 6 are referred to known species, 7 are described as new ones and 5 are identified to the genus. Some preliminary data are given on the influence of microsporidians on the host population, their specificity and variability. | 145,569 | [
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The results of non-operative management of stiff joints in the hand. | We selected 500 patients randomly from a total of 1300 patients seen in our Hand Rehabilitation Center between 1971 and 1975; 212 of the 500 presented with a chief complaint of stiff hand joints. Of the 212 patients treated non-operatively, 173 responded sufficiently to this treatment alone. Of the 789 stiff joints, 68... | 145,602 | [
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Effect of acetaldehyde on functioning of cardiac muscle at the ultrastructural level. | The effect of acetaldehyde, the hepatic metabolite of alcohol, on the functioning of cardiac muscle was investigated at the subcellular level. Concentrations of acetaldehyde that occur in plasma failed to alter either the microsomal Ca2+-accumulating and ATPase activity or the Ca2+-accumulating activity of the mitochon... | 145,633 | [
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0.2281444,
0.2463607,
0.3539715,
0.04874847,
0.0162... |
Characterization of myosin from patients with asymmetric septal hypertrophy. | Human cardiac myosin isolated from operatively obtained samples of ventricular septum and left ventricular free wall of patients with asymmetric septal hypertrophy (ASH) was compared, with respect to structural and enzymatic properties, to myosin isolated from hearts of patients without heart disease. The following par... | 145,640 | [
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Increased protein synthesis during right ventricular hypertrophy following pulmonary stenosis in the dog. | The synthesis rates of mixed protein in the left and right ventricles were the same in normal dogs, averaging 7.8% per day. After five days, pulmonary stenosis protein synthesis rate in the right ventricle increased rapidly to 13.6% per day and subsequently decreased to near normal by 12 days, during which time the rig... | 145,641 | [
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0.1324046,
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Necrotizing lymphadenitis: possible acute toxoplasmic infection. | A rapid rise in serum hemagglutination antibody (HA) titers for toxoplasma was detected about 2 months after the onset of cervical lymphadenopathy in two patients with necrotizing lymphadenitis. These lymph nodes proliferation of histiocytes with nuclear debris, phagocytized macrophages and necrotic areas, and the asso... | 145,720 | [
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0... |
Giant cell tumor of bone: fine structural localization of acid phosphatase. | The fine structural localization of acid phosphatase in the different cells in a benign giant cell tumor of bone has been studied. Stromal cells type 1 and 2 (fibroblast-like and macrophage-like, respectively) showed the presence of lead phosphate precipitate following incubation in a Gomori-type lead salt medium only ... | 145,723 | [
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Transplacental effects of nitrosamines in Syrian hamsters. III. Dimethyl- and dipropylnitrosamine. | The aliphatic nitrosamines dimethylnitrosamine (DMN), diethylnitrosamine (DEN), dipropylnitrosamine (DPN), and dibutylnitrosamine (DBN) reached fetal tissue in quantitatively measurable amounts after subcutaneous administration to pregnant Syrian hamsters. The compounds were present for at least 2 h in maternal blood, ... | 145,751 | [
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[The carrier potential of liposomes for methotrexate. Changing of the tissue levels of methotrexate in the organs of mice (author's transl)]. | Drugs entrapped in liposomes (artificial lipid vesicles) exhibit different pharmacokinetics after intravenous application than drugs injected in a free form. The folidacidantagonist methotrexate can be entrapped in liposomes in a therapeutically useful concentration (0.5 mg MTX/ml) and can be stored with high stability... | 145,758 | [
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[The influence of the type of monofilament suture on re-epithelialisation of corneal grafts (author's transl)]. | We have investigated whether a correlation exists between the quality of graft epithelialisation and three types of suture: triangular sutures, continuous and interrupted sutures. The study concerns 192 randomly chosen keratoplasties, performed by the same surgeon using suture material of 9 or 10/0 monofilament. We use... | 145,845 | [
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Tentoxin. An uncompetitive inhibitor of lettuce chloroplast coupling factor 1. | The interaction of tentoxin [cyclo-(-L-leucyl-N-methyl-(Z)-dehydrophenylalanyl-glycyl-N-methyl-L-alanyl-)] with solubilized lettuce chloroplast coupling factor 1 was characterized by direct binding studies, measurement of the time course of ATPase inhibition, and steady-state enzyme kinetics. Neither substrates, produc... | 145,874 | [
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Light and electron microscopy study on urethral regeneration. | In a series of experiments on dogs, it was feasible to replace a segment of urethra using wide-mesh Dacron. Light and electron microscopy study on the regenerated urethra showed no evidence of muscle, cavernous tissue and nerve regeneration. Although an excess of fibrous tissue surrounded the regenerated urethra, there... | 145,885 | [
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Possible role of intestinal alkaline phosphatase activity in thiamine transport. | Thiamine deficiency caused a marked decrease of intestinal alkaline phosphatase (al-Pase) activity, but had no effect on the Ca++-ATPase activity and Ca++-absorption in rats. The al-Pase activity was significantly decreased 1 h after oral administration of ethanol at 0.5 and 2.5 g/kg. In contrast, Mg++-, Ca++-and (Na+ ... | 145,948 | [
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A histochemical study of fibrinolytic activity and inhibition of plasmin in the lungs of some animal species. | Determined by the histochemical fibrin slide technique, the fibrinolytic activity of lungs decreased in the following order of species: rat, mouse, pig, guinea pig, rabbit, cattle. Examined by the fibrin slide 'sandwich' technique, inhibition of plasmin showed the opposite mode of decrease. The possible role of these ... | 145,993 | [
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[The diagnostic value of mammography during pregnancy and lactation (the radiological features of the breast during pregnancy) (author's transl)]. | During early and late pregnancy and lactation, there is an increase in the size of the breasts, with increased density of their structure. The moderately dense parenchyma in young women is characterised by a) wavy contours of the subcutaneous zone and b) linear or oval translucencies in the central parenchyma. Our inve... | 146,000 | [
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... |
Induction of specific unresponsiveness against the C3H M1s=antigen in mice, increase of suppressive capacity of C3H X CBA F1-lymphocytes after sensitization against CBA lymphoid cells. | Injection of adult CBA mice with lymphocytes from C3H X CBA donors leads to a specific reduction of the MLC reactivity of the recipients' lymphocytes. This effect is mediated by a population of F1-lymphocytes which do not seem to possess the relevant MLC-stimulatory M1s-antigen. In this investigation we have shown that... | 146,023 | [
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... |
Colicins and bacterial membranes: structures and functions. II. Studies on reconstituted homologous and hybrid membranes prepared from cytoplasmic membranes of untreated and colicin K-treated bacteria. | Cytoplasmic membranes of Escherichia coli K12 C600 treated and not treated with colicin K were dissociated into unsolubilized and solubilized fractions. Neither fraction catalyzed ATP-linked transhydrogenase activity. Mixtures of unsolubilized fractions of the untreated bacteria with solubilized fractions of either the... | 146,040 | [
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Effect of thymosin on T-lymphocyte functions in patients with acute thermal burns. | Patients with severe thermal burns demonstrate a decreased cellular immunity. The purpose of this study was to ascertain whether thymosin enhances in vitro T-lymphocyte functions in such patients. Peripheral blood lymphocytes were obtained serially from 22 burned patients and 35 health adults. In vitro lymphocyte funct... | 146,096 | [
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Nucleotide sequence of Neurospora crassa cytoplasmic initiator tRNA. | Initiator methionine tRNA from the cytoplasm of Neurospora crassa has been purified and sequenced. The sequence is: pAGCUGCAUm1GGCGCAGCGGAAGCGCM22GCY*GGGCUCAUt6AACCCGGAGm7GU (or D) - CACUCGAUCGm1AAACGAG*UUGCAGCUACCAOH. Similar to initiator tRNAs from the cytoplasm of other eukaryotes, this tRNA also contains the sequen... | 146,192 | [
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0.15... |
Use of a new simple device, the airflometer, in detecting changes in airways obstuction. | A simple device for measuring ventilatory function, the airflowmeter, was found to be at least as sensitive as the Wright peak-flow meter in detecting histamine-induced bronchoconstriction in asthmatic patients. The apparatus also was found suitable for monitoring ventilatory function by the patients themselves at home... | 146,254 | [
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[Chordomas. Excision of a lumbar chordoma: 2 1/2 years survival without signs of recurrence and without functional complications]. | In connection with surgical removal of a chordoma in the lumbar region by large excision, followed by 31-month survival of the patient without complications, personal experience of 8 chordomas operated on over the last 20 years is reported. The authors believe their observations show the value of active surgical treatm... | 146,255 | [
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0.01551178,
... |
Experimental induction of melanotic tumors in syrian golden hamsters by transplacental and topical application of ethylnitrosourea. | Pregnant Syrian golden hamsters were treated with a single intra-peritoneal injection of ethylnitrosourea (ENU) solution a few hours pre-parturition. Offspring either received no further treatment or from 6 weeks of age, bi-weekly application of ENU solution in acetone for 20 consecutive weeks. Progeny from non, transp... | 146,325 | [
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0.00178465,
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Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine. | Two 8-month-old and two 4-month-old male beagle dogs received 250 ml of 150 microgram/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) and 2% Tween 60 mixed with a pellet diet twice a day for 8 months as the same methods used for mongrel dogs in our first report [Juntendo Medical Jouranl 19, 579-583 (1973)]. G... | 146,326 | [
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[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)]. | The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat li... | 146,342 | [
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The quantitative determination of metabolites of 6-mercaptopurine in biological materials. IV. An improved separation method for twentytwo compounds related to purine and 6-thiopurine metabolism using high-pressure liquid cation-exchange chromatography. | An improved method is described for the separation of 22 compounds normally related to purine and 6-thiopurine metabolism in biological materials using high-pressure liquid cation-exchange chromatography on strongly acidic exchange resin. The column (0.8 X 100 cm) is eluted with 0.4 M ammonium formate, pH 4.6, at a lin... | 146,352 | [
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... |
Prerequisites for tuboplasty. | Techniques in measuring tubal patency and interpretation of findings can be misleading. Laparoscopic study of infertile women with suspected, diseased fallopian tubes is always prerequisite to tuboplasty. Observations must be accompanied by intrauterine injection of adequate amounts of dye and gentle tubal manipulation... | 146,392 | [
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Role of hydrophobic interaction in hapten-antibody binding. | The precipitation reaction of bovine serum albumin coupled with p-azophenylleucine with homologous antibody was inhibited by several structurally related haptens. The isobutyl group substituent on alpha-carbon atom of the leucine residue contributed more than -5.8 Kcal/mol to the free energy of binding. This value was ... | 146,401 | [
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0.05053303,
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[Allergic contact eczema and vitiliginous depigmentations caused by paratertiary butylphenol]. | Allergic contact eczema and vitiliginous depigmentations caused by paratertiary butylphenol. In a case of allergic contact eczemas due to an occupational contact with paratertiary butylphenol, vitiliginous depigmentations appeared after a latency period of several years. Disorders of cellular immune reactions, struma a... | 146,480 | [
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[A deep colored antimony compound from dehydroepiandrosterone (3beta-hydroxy-5-androstene-17-one). 79. Steroids and Sterines]. | Heating of dehydroepiandrosterone under nitrogen with a concentrated solution of SbCl3 in C6H5COCl (3 h at 90 degrees C) leads to a dark violet-coloured crystalline product of the composition C38H46Cl7O2Sb2 with antomony in a trivalent state. Treatment with hydrochloric acid yields an antomony-free brown-coloured produ... | 146,499 | [
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0.22151... |
Gaps in DNA induced by neocarzinostatin bear 3'- and 5'-phosphoryl termini. | Neocarzionstatin (NCS)-induced strand breakage of DNA generates nonfunctional binding sites for the E. coli DNA polymerase I. Treatment of the NCS-nicked DNA with alkaline phosphatase at 65 degrees C prior to the polymerase reaction results in 60-100-fold stimulation of dTMP incorporation whereas in a control not treat... | 146,515 | [
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-... |
[Experimental endoparasitism of Trypanosoma brucei in Blabera fusca: parasite survival and hemoglobin toxicity]. | Attempts for infestation of the cockroach, Blabera fusca, by Trypanosoma brucei directly inoculated in the insect's haemocoele allowed to prove the obligation of the presence of red cells in the cockroach for the survival of the flagellates, in variable assessment. These free and moving trypanosomes may be studied in t... | 146,541 | [
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... |
[Mutagenicity of the metabolites of the epoxide-diol pathway of safrole and its analogs. Study on Salmonella typhimurium]. | Mutagenicity of the metabolites of the expoxide-diol pathway of safrole and analogues was studied on Ames' strains with Ames' method. Safrole, eugenol, eugenolmethylether, estragol, allylbenzene and 1'-hydroxysafrole, are not mutagen on TA 1535, TA 100 (point mutation) and TA 1537, TA 1538, TA 98 (frameshift mutations)... | 146,546 | [
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-0.09958413,
... |
[In vitro effects of aminoglycosides and cephalosporins on rat kidney lysosomes]. | The study of aminoglycoside and cephalosporin antibiotics was performed using a subcellular system in vitro. Lysosomes were purified from rat kidney tissue homogenates by a linear sucrose gradient centrifugation technique. The lysosomal membrane integrity was estimated by measuring the free N-acetyl-beta-D-glycosiminid... | 146,551 | [
-0.09628387,
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0.07190651,
0.6387935,
0.05479599,
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0.1175202,
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0.1248726,
0.1223597,
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0.1920455,
0.2456982,
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-0.664861,
-0.02780181,
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0.1855294,
0.4974621,
-0.06826382,
-0.005830864,... |
[Variations in the effect of clonidine on arterial pressure in rats in the presence of various anesthetics]. | The central hypotensive agent, clonidine (30 microgram/kg i.v.) has been injected in normotensive rats anesthetized with various agents. This dose of clonidine elicits usually a biphasic blood pressure response, i.e. a transient increase due to peripheral vasoconstriction, followed by a long lasting decrease. This has ... | 146,557 | [
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-0.135158,
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0.1072738,
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0.1337253,
0.3080765,
0.2159399,
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-0.4887886,
-0.001737657,
0.0722883,
0.3461898,
-0.1259424,
-0.02821686,
0.02372971... |
A cytogenetic survey of an institution for the mentally retarded: I. Chromosome abnormalities. | A cytogenetic survey of 475 patients in an institution for the mentally retarded is reported. The chromosomes of all patients were studied using both a non-banding and a G-banding technique in order to estimate the relative efficiency of the two technique in detecting structural rearrangements of the chromosomes. A tot... | 146,575 | [
-0.1652196,
0.1186343,
0.2798824,
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0.1694413,
0.2057687,
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0.06037513,
0.07568116,
0.1593133,
0.2032655,
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0.4414028,
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0.26132,
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0.3539913,
0.2462662,
0.1518473,
-0.4151... |
Observations of ridge appearances in a normal population and in Down syndrome patients (21-trisomy) using the scanning electron microscope. | A celluloid plate containing a drop of amyl acetate was pressed to the skin. The impression thus obtained was coated with carbon and gold and observed under the scanning electron microscope. Impressions from the fingers of the normal population showed the crests and furrows of the finger prints clearly. The impressions... | 146,576 | [
0.05143237,
0.1058053,
0.1381778,
0.07714713,
0.1513569,
0.2131371,
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0.2650876,
0.1144675,
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0.1635858,
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-0.0669935,
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-0.1916113,
0.4102619,
0.3165407,
-0.1285097,
-0.2... |
Low-dose minocycline therapy in tetracycline-recalcitrant acne vulgaris. | Ninety-one patients with acne vulgaris were selected for a two-part study primarily because the severity of disease suggested that it might be tetracycline-recalcitrant. Of the eighty-eight patients completing the first part of the study, thirty-two were judged to have tetracycline-nonresponsive acne and received 50 mg... | 146,595 | [
0.0363539,
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0.07563006,
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-0.2261503,
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0.1567958,
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0.1271055,
0.2330861,
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0.09921528,
0.009256334,
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-0.271528,
0.3635241,
-0.3050454,
0.009800239,
0.07025231,
0.09653716,
0.060667... |
Measurement of testosterone and dehydroepiandrosterone 16alpha-hydroxylase activities by a tritium exchange method. | A new isotopic method, based upon the stereospecific replacement of a proton (3H) by a hydroxyl group has been developed for the measurement of rat liver testosterone and dehydroepiandrosterone 16alpha-hydroxylase activity. Specifically 16-tritiated substrates were prepared by microbiological (Cylindrocarpon radicicola... | 146,601 | [
-0.2126395,
0.1127759,
-0.13815,
0.1750353,
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0.2240388,
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0.1916023,
0.09289669,
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0.4359508,
0.1855046,
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0.07531662,
-0.05585702,
0.07123382,
0.5123152,
0.0152178,
0.2202353,
0.15816... |
Evaluation of sequelae of tubal ligation. | An evaluation was made of 268 patients undergoing elective sterilization with respect to the ensuing development of menorrhagia, pelvic pain, and the need for gynecologic surgery. Preoperative and follow-up postoperative questionnaires of patients undergoing laparoscopic sterilization were compared, and additional data... | 146,613 | [
0.08378439,
0.09382986,
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-0.1678033,
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0.05854718,
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0.07034047,
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0.2369101,
0.09077927,
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0.1531485,
-0.1449257,
-0.07050589,
0.1864326,
0.3094345,
-0.01863... |
[The normal pancreas as seen on the computerised tomogram (author's transl)]. | The normal appearances of the pancreas as seen on computerised tomograms (EMI) has been demonstrated in fifty normal patients and correlated with fifteen post mortem studies on patients with a normal pancreas. The problems of optimal demonstration of the pancreas on computerised tomograms and possible sources of error ... | 146,653 | [
0.03771225,
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0.0007313229,
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0.05377642,
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0.3758649,
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-0.12121,
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0.2047557,
-0.0453805,
-0.04892598,
0.05222378,
0.07698074,
-0... |
[Computer tomographic and scintigraphic aspects of subdural haematomas (author's transl)]. | Cerebral computer tomography in cases of emergency is undoubtedly superior to conventional neuro-radiological methods. The changes during resorption of intracranial bleeds, which are due to their particular physical properties, can supply valuable diagnostic information, but under particular circumstances they may obsc... | 146,654 | [
-0.09628661,
0.04944816,
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0.04053162,
0.148677,
0.1676948,
0.4569225,
0.2202116,
0.03816715,
-... |
Prosthetic materials and wound healing. Critical evaluation of six different materials. | Six different materials (three mesh and three cloth) commonly used for the repair of abdominal wall hernias were evaluated in 180 rats. Macroscopic, bacteriologic, mechanical and histologic criteria were used to investigate tolerance and resistance of the foreign material. Findings demonstrate the superiority of mesh o... | 146,683 | [
0.01389009,
0.2303871,
-0.2440989,
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0.02087803,
-0.06519929,
0.1390646,
0.1047878,... |
The canine eye: in vitro dissolution of the barriers to aqueous outflow. | Facility of aqueous outflow and time-dependent changes in its hyaluronidase-sensitive and hyaluronidase-resistant components were evaluated in freshly excised canine eyes by constant pressure quantitative aqueous perfusion. Mean baseline facility of outflow was 0.24 microliter/min/mm Hg. With prolonged perfusion at con... | 146,684 | [
-0.1307303,
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0.3187529,
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0.02437315,
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0.1368976,
-0.1540272,
0.08335429,
-0.08669375,
0.0621204... |
Huntington's disease: improvement with an anticoagulant-psychotherapy regimen. | A 45-year old women with Huntington's disease (HD) was followed for three years while under an anticoagulant-psychotherapy regimen. The chorea disappeared and the patient improved rather than deteriorating as predicted. All psychotropic drugs were discontinued. This case of reversal of the disease may help to confirm t... | 146,722 | [
-0.08484167,
0.3728959,
-0.0523772,
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0.2802225,
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0.2683282,
0.8653146,
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0.1571537,
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0.2978103,
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0.1176015,
-0.05391134,
-0.08887179,
-0.105809,
... |
Fibrinolytic enzyme in the lining walls of chronic subdural hematoma. | Active plasmin, available plasmin, and total plasminogen were measured by Enzo-diffusion fibirn plate techniques in 11 cases and level of tissue activator and tissue fibrinolytic activities in another 11 cases with chronic subdural hematoma. The values were too small to be measured in some instances. Anti-plasmin in th... | 146,730 | [
-0.1699192,
-0.08021406,
0.09329992,
-0.1156027,
0.05585158,
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0.1943218,
0.2029996,
0.05004204,
0.02747633,
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0.02838729,
0.05956703,
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-0.6366956,
0.04107449,
-0.2059893,
0.2896129,
0.1347922,
-0.2010341,
-0.1336388... |
Reoperation after lumbar intervertebral disc surgery. | This retrospective study includes 53 patients who underwent reoperation after failure of lumbar disc surgery to relieve pain. All patients had leg pain before reoperation, which was successful in 28% of cases. Most clinical features, such as persistence or mode of recurrence of pain, radicular quality of pain, positive... | 146,731 | [
0.5659605,
0.114701,
0.08736906,
-0.03318835,
0.06909738,
-0.4824105,
-0.001009994,
-0.1012391,
0.1319348,
-0.2378751,
0.142957,
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0.09773344,
0.1055533,
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0.1086842,
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0.0472884,
0.01460772,
-0.5417126,
0.02589978,
-0.07935996,
0.008312181,... |
[Intertrochanteric osteotomies. A critical study of the clinical radiologic evaluation]. | The authors describe the technique that they have used in approximately 500 intertrochanteric osteotomies of the femur. The technique was satisfactory in the production of bony union but in ten per cent of cases there were errors of correction of 5 degrees or more. An analysis of errors related to the radiological tech... | 146,887 | [
-0.008492751,
0.1397007,
-0.1028495,
0.02136337,
-0.07186452,
-0.1699185,
-0.2431206,
0.1086213,
-0.05956851,
-0.06080576,
0.1459311,
-0.2595194,
-0.1428324,
-0.3857927,
-0.4725359,
-0.2632759,
-0.08678594,
0.3348113,
-0.1298333,
0.5124377,
0.2535312,
-0.07221984,
-0.0165... |
[Attitude of the paralytic supination of the forearm in children. Surgical treatment in 19 cases]. | Nineteen cases of paralytic supination contracture have been surgically treated in children and teenagers. Three successive stages are described - 1) reducible deformity 2) contractures of soft tissues and 3) skeletal deformities. Surgical treatment aimed to improve the patient cosmetically and functionally. Ideally, t... | 146,889 | [
0.07451053,
-0.1673329,
0.3232198,
-0.1254409,
0.1178948,
-0.1878567,
-0.5569036,
-0.04971198,
0.0732198,
0.1653657,
0.136462,
-0.0977253,
-0.06742922,
0.09579936,
-0.02465002,
-0.3481685,
-0.01225718,
-0.07246107,
-0.2005389,
-0.08158245,
0.4469081,
0.05927764,
-0.035479... |
Prognosis of chronic obstructive lung disease in relation to radiology and electrocardiogram. | Survival in relation to radiological and electrocardiographical changes was examined in a retrospective study of 228 hospital patients aged 40-69 years with a FEV1 of 1.5 1 or less, and a FEV1 of 70% or less of the vital capacity due to chronic obstructive lung disease. The only radiological changes which influenced su... | 146,913 | [
0.3656591,
-0.01020996,
-0.4024989,
-0.2285193,
-0.1193473,
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0.259217,
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-0.275474,
-0.2531454,
0.02438288,
0.3229588,
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0.2492453,
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0.005815433,
0.438008,
0.1801301,
0.1084853,
0.2165384,
0.316424,
-0.1284558,
0.031... |
On the HLA-B,D map distance. | HLA--A,--B,--C and--d typing and intra-familial MLC studies in 21 couples and their 91 children revealed three B, D recombinants in 165 informative haplotypes. This corresponds to a B,D map distance of 1.8 centiMorgans, which is somewhat higher than previous estimates based on intra-familial MLC chessboard experiments.... | 146,925 | [
-0.182013,
0.1734701,
0.05714084,
0.2447109,
0.490991,
-0.2041647,
-0.3601534,
0.07491057,
-0.02767942,
0.04752794,
0.1157396,
0.2624641,
0.2332407,
0.2290478,
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0.01220443,
0.04582171,
0.04869993,
0.3994359,
0.2654945,
-0.2131024,
0.03... |
[ATPase activity and processes of calcium transport in membranes of sarcoplasmic reticulum of skeletal muscles with E-avitaminotic dystrophy]. | Peculiarities of functioning of the sarcoplasmic reticulum muscles membranes with E-avitaminotic distrophy were studied. It was determined that the level of ATP-dependent consumption of Ca2+, value of the Mg2+, Ca2+-ATPase activity and an amount of the intermediate phosphorylated product forming in the reaction of ATP ... | 146,930 | [
-0.5701919,
-0.04241569,
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0.2390504,
0.05255189,
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-0.4492927,
0.3021476,
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0.0895182,
0.1688115,
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0.2538623,
-0.1869773,
-0.7424673,
0.05163581,
-0.8113132,
-0.2096611,
-0.1388638,
-0.02573906,
0.570569,
0.2373517,
-0.1201447... |
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