title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Temperature-sensitive mutants of simian virus 40 selected by transforming ability. | Eight temperature-sensitive mutants of simian virus 40 which transform rat cells at 32.5 C but not at 38.5 C have been isolated. All the mutants were also temperature sensitive for replication in African green monkey kidney cells and five of them were classified into a single complementation group. No mutant incapable ... | 167,187 | [
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Fatal pox infection in a rough-legged hawk. | Natural pox infection occurred in a free-living rough-legged hawk (Buteo lagopus) in northeastern North Dakota. Gross, histological and electron microscopic findings were typical of pox infection, and characteristic lesions developed in red-tailed hawks (Buteo jamaicensis) but not in great horned owls (Bubo virginianus... | 167,207 | [
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Phospholipase C catalyzed formation of sphinogomyelin--14C from lecithin and N-(-14C)-oleoyl-sphingosine. | Commercial preparations of Clostreidium perfringens were incubated with phosphatidyl choline and N-1-(-14C) oleoylsphingosine. A radioactive product was formed which cochromatogramed with spingomyelin standard in three different solvent systems. Several other phospholipases and phosphatases were unable to catalyze th... | 167,259 | [
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Structural and compositional changes attending the ultracentrifugation of very low density lipoproteins. | The effects of repetitive ultracentrifugation on the physical and chemical properties of very low density lipoproteins (VLDL) were investigated. VLDL recentrifuged one to seven times were characterized by chemical analyses, analytical ultracentrifugation and electron microscopy. The VLDL content of triglyceride was inc... | 167,365 | [
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Follicle stimulating hormone stimulation of 125-I-human chorionic gonadotropin binding in porcine granulosa cell cultures. | In order to see if FSH acts directly upon the granulosa cell to stimulate hCG binding, granulosa cells harvested from small 1-2 mm porcine follicles were grown in 250 ml flasks in chemically defined media containing 0.05 mug/ml highly purified human FSH for 2, 4, and 6 days. The defined medium consisted of culture medi... | 167,375 | [
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[Reactivity of the adrenals to ACTH in rats with alloxan diabetes]. | Experiments were conducted on rats. A study was made of the adrenal gland ACTH reactivity under conditions of alloxan diabetes. The function of the adrenal gland increased one month after the administration of alloxan; this was indicated by an increase of their absolute and relative weight, by an elevation of the corti... | 167,371 | [
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[Effect of ACTH, TTH, and STH on respiration and oxidative phosphorylation in the liver of hypophysectomized rats]. | An experimental study was make of the changes in respiration and of the oxidative phosphorylation in the hepatic mitochondria of the hypophysectomized albino rats, with consideration to the regulatory effects of the ACTH, TTH, and STH. There was an intensification of the conjugation of the oxidative and of the phospho... | 167,370 | [
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Rubella and rheumatoid arthritis: hyaluronic acid and susceptibility of cultured rheumatoid synovial cells to viruses. | Synovial cell lines were established from patients with rheumatoid arthritis (RA) and from normal human embryos. High levels of hyaluronic acid (HA) were produced by some RA cell lines, some of which were partially or completely resistant to infection with Newcastle disease virus (NDV), vesicular stomatitis virus (VSV)... | 167,379 | [
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Differences and similarities between guanosine 3',5'-cyclic monophosphate phosphodiesterase and adenosine 3',5'-cyclic monophosphate phosphodiesterase activities in neuroblastoma cells in culture. | There are phosphodiesterase activities in both particulate and supernatant fractions which hydrolyze guanosine 3',5'-cyclic monophosphate (cGMP) and adenosine 3',5'-cyclic monophosphate (cAMP) with an apparent Km of 2-8 muM and with an apparent Km of 44-222 muM. 4-(3-Butoxy-4-methoxybenzyl-2-imidazolidinone (RO20-1724)... | 167,381 | [
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Concerning the relationship between protein synthesis and adenosine-3',5'-cyclic phosphate-stimulated steroidogenesis in isolated rat adrenal cells. | Inhibitors of protein synthesis decrease protein synthesis in isolated rat adrenal cells to a greater extent than they decrease adenosine-3',5'-cyclic phosphate (cyclic AMP)-stimulated steroidogenesis. At low concentrations of the inhibitors, varying degrees of recovery of the rate of steroidogenesis occurs with increa... | 167,383 | [
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Molecur mechanism of action of the radioprotective substance WR 2721. | The radioprotective effect of WR 2721 on catalase and the type and loci of its interaction with the enzyme have been investigated by means of spectrophotometric and electron spin resonance, (ESR) methods. The radiation damage, indicated by a change in enzymatic activity and in the Soret absorption band, has been the l... | 167,397 | [
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The demonstration by interference tests of an infective agent in fetuses from ewes inoculated with Border disease tissue. | Fetuses and placental tissues were taken from pregnant ewes at intervals varying between eight and 21 days after inoculation with tissue suspensions from cases of Border disease. Virus isolation procedures involving the detection of a cytopathic effect in tissue cultures with or without interference tests produced univ... | 167,408 | [
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Herpesvirus hominis infections in renal transplant recipients. | A longitudinal, prospective study of herpesvirus hominis (HVH, herpes simplex virus) was carried out in immunosuppressed renal allograft recipients using serologic, virologic and clinical techniques. The final study group consisted of 37 patients of which 31 were followed for at least 2 months and 26 for more than 1 ye... | 167,430 | [
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Immunofluorescent localization of cyclic AMP in toad urinary bladder: possible intercellular transfer. | By use of an immunofluorescent cytochemical staining technique, adenosine 3',5'-monophosphate (cyclic AMP) has been localized in toad bladder epithelial cells. Within 2 minutes after addition of vasopressin, staining intensity increases in both mitochondria-rich and granular cells. This finding, taken together with the... | 167,437 | [
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Parasitology survey and seroepidemiology of amoebiasis in South Kalimantan (Borneo), Indonesia. | A parasitology surevy was conducted among inhabitants of 7 villages in 3 regencies in South Kalimantan Province, Indonesia. A total of 2,169 stool specimens, 2,756 blood smears and 1,027 serum specimens were obtained, representing samples from approximately 10%, 12% and 5% of the population, respectively. One to 8 diff... | 167,454 | [
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Ultrastructural pathology of leaf cells of ryegrass (Lolium multiflorum) infected with ryegrass mosaic virus. | Ryegrass mosaic virus particles and virus induced lamellar inclusions were found in mesophyll and epidermal cells of virus infected ryegrass leaves. The lamellar inclusions were occasionally found in phloem cells also. Virus particles occurred in cytoplasm, inside plasmodesmata and often in membrane bound sacs embedded... | 167,468 | [
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[Comparison of the sensitivity of laboratory animals and tissue cultures to infection with Aujeszky's disease virus]. | In mice and guinea-pigs high susceptibility was demonstrated following i. c. administration of the virus, approximately equalling to that of rabbits and tissue cultures. Also a relatively high susceptibility of guinea-pigs was demonstrated, with very distinct clinical symptoms of the disease, as compared with mice and ... | 167,500 | [
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Cytologic detection of early Paget's disease of breast with improved cellular collection method. | Improved cellular collection method and cytologic criteria for diagnosis of Paget's disease of the breast are presented. When indicated, the cytologic test is highly recommended for the early detection and pre-operative diagnosis of the minimal breast cancer10. | 167,540 | [
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Interactions of ethanol with cyclic AMP. | Ethanol and other alcohols stimulate adenylate cyclase activity in various tissues and potentiate its stimulation by some hormones. This effect, however, usually requires a high alcohol concentration. In some cases, an unknown substance, different from cyclic AMP, was formed from ATP in the presence of an alcohol and m... | 167,556 | [
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Impaired renal response to parathyroid hormone in potassium depletion. | In potassium depletion, a possible alteration of the proximal tubular response to parathyroid hormone (PTH) was evaluated in rat kidney. 1) There were impairments of both phosphaturic and urinary cyclic AMP responses to PTH. The site of the impairment was further investigated by studying the PTH-dependent cycle AMP sys... | 167,590 | [
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A phylogenetic study of the role of cyclic AMP in lipid synthesis in vertebrates. | The effect of cyclic AMP on the incorporation of acetate-2-14C into sterols and fatty acid in vitro in slices of liver and intestine was examined in various representatives of the vertebrate group. In no instance was an effect on lipid synthesis noted in intestine. Cyclic AMP exerted no significant effects on hepatic l... | 167,595 | [
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Acute effects of ACTH on dissociated adrenocortical cells: quantitative changes in mitochondria and lipid droplets. | To study the role of certain organelles in steroidogenesis, dissociated rat adrenocortical cells were incubated for two hours with ACTH at a concentration that induces a high level of steroid production. Sections of ACTH treated and untreated cells were photographed in the electron microscope, and morphometric analysis... | 167,616 | [
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Comparison of the characteristics of avian reoviruses isolated from the digestive and respiratory tract, with viruses isolated from the synovia. | Two-week-old gnotobiotic chicks were inoculated in the foot pad with viruses isolated from synovia and synovial membrane-WVU 1464-29H, WVU 1675, WVU 2937, WVU 2986, and WVU 71-212; from digestive tract-reoviruses 24, 25, and 59; or from respiratory tract-reovirus Fahey-Crawley (FC). All viruses induced swelling of the ... | 167,621 | [
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Growth curves of anaerobic bacteria in solid media. | Simple pour plate and spectrophotometric techniques for the evaluation of growth curves of several anaerobic bacteria on solid media are described. Three basic patterns of anaerobic growth were observed. The curves obtained were very reproducible when studied on separate occasions. The curves obtained by spectrophotome... | 167,660 | [
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Effects of lead on the lipid composition of Micrococcus luteus cells. | Micrococcus luteus cells cultivated in medium containing lead salts exhibited a sequence of changes in the quantity of total cellular lipids with essentially no changes from normal cellular yields. The lipid composition of cells cultivated one to four times was moderately decreased (phase I) whereas that of cells culti... | 167,661 | [
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Wound infection during the Yom Kippur war: observations concerning antibiotic prophylaxis and therapy. | Eighty-eight episodes of wound associated infection were identified among 624 consecutively admitted battlefield casualties. Ninety-one per cent of infections occurred during the administration of antibiotic therapy or prophylaxis and 65% were associated with the use of multiple antibacterial agents. Gram negative baci... | 167,666 | [
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Training examiners to administer a quantitative neurological examination for a multicenter clinical trial. | A battery of quantitative neurological tests was used in a multicenter clinical trial to compare ACTH with placebo for the treatment of patients with multiple sclerosis in acute exacerbation. Since the battery of tests was administered in ten centers by physical therapists, it was critical that the examiners were well ... | 167,673 | [
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Exacerbation and reactivation of Herpesvirus hominis infection in mice by cyclophosphamide. | Cyclophosphamide has been shown to potentiate the growth of Herpesvirus hominis in the skin of Webster Schneider mice. Higher skin yields of virus were obtained, marked dissemination of virus to the brain was produced and mortality in mice was increased. Serum neutralizing antibody titres were suppressed. The system ma... | 167,686 | [
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0.01707568,
0.05312477,
0.3345254,
0.4392723,
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0.09733099,
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0.09345879,
0.1282192,
0.03531647,
0.1357119,
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... |
The effect of arginine deprivation on the cytopathogenic effect and replication of human cytomegalovirus. | Arginine is necessary for the development of the cytopathogenic effect of human cytomegalovirus in human embryonic fibroblasts. It is also required, though in greater concentrations, for the production of infective virions, the requirement being at an early stage of replication. Inhibitor studies suggested that this bl... | 167,690 | [
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0... |
Characteristics of the sleep of men in simulated space flights. | A study of the sleep of men in simulated space flight has shown that, during different effects (diminished motor activity, noise, rotation), monotony and time of the exposure is the general pathogenetic factor producing sleep disturbances. The monotony factor was responsible for typical changes in sleep function (diffi... | 167,706 | [
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... |
Lack of relationship between activity of chromatin-bound proteinase and cell growth rates. | Proteinase associated with chromatin isolated from liver and hepatoma of rat is stimulated by salt, and, of the histone fractions, lysine-rich (F1) histone is preferentially degraded by this enzyme at an ionic strength comparable with that found in the nucleus. However, there appears to be no strict relationship betwee... | 167,717 | [
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... |
Molecular weights of estrogen and androgen binding proteins in the liver of Xenopus laevis. | [3-H]Estradiol-17beta and [3-H]dihydrotestosterone binding proteins in the cytosol fraction of liver from both male and female Xenopus laevis were characterized by electrophoresis on polyacrylamide gels. These binding proteins, which were indistinguishable based upon their mobilities on gels of different acrylamide con... | 167,818 | [
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... |
Actions of insulin, epinephrine, and dibutyryl cyclic adenosine 5'-monophosphate on fat cell protein phosphorylations. Cyclic adenosine 5'-monophosphate dependent and independent mechanisms. | Endogenous and hormone-induced protein (polypeptide) phosphorylations were studied in isolated rat fat cells, in fat pads, and in subcellular fractions obtained from fat tissue under different physiological conditions. Insulin (25-100 muU/ml) increased the incorporation of 32P into two proteins: insulin-phosphorylated ... | 167,823 | [
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... |
2-substituted derivatives of adenosine and inosine cyclic 3',5'-phosphate. Synthesis, enzymic activity, and analysis of the structural requirements of the binding locale of the 2-substituent on bovine brain protein kinase. | A number of 2-substituted cyclic nucleotide derivatives were synthesized and investigated as activators of cAMP-dependent protein kinase and as substrates for and inhibitors of cAMP phosphodiesterase. Ring closure of 5-amino-1-beta-D-ribofuranosylimidazol-4-carboxamide cyclic 3',5'-phosphate (1) with various aldehydes ... | 167,824 | [
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... |
EPR studies on compound I of horseradish peroxidase. | Compound I of horseradish peroxidase (donor: hydrogen-peroxide oxidoreductase EC 1.11.1.7) was studied by EPR at low temperatures. An asymmetric signal was found, about 15 Gauss wide and with a g-value of 1.995, which could be detected only at temperatures below 20 K and which had an intensity corresponding to about 1%... | 167,831 | [
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0.01446494,
0.... |
Self-association of the major protein component of bovine serum high density lipoprotein. | The major protein component of bovine high density lipoprotein was investigated in solution by fluorescence polarization and ultracentrifugal techniques. A fluorescent derivative of this protein with 1-dimethylaminonaphthalene-5-sulfonyl chloride was employed in the fluorescence experiments. Over the concentration rang... | 167,838 | [
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Bile salt alteration of ion transport across jejunal mucosa. | The effect of conjugated dihydroxy and trihydroxy bile salts on electrolyte transport across isolated rabbit jejunal mucosa was studied. Both taurochenodeoxycholic acid and taurocholic acid increased the short-circuit current (Isc) in bicarbonate-Ringer solution but not in a bicarbonate-free, chloride-free solution. Ta... | 167,840 | [
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Differentiation of fluorides-stimulated and non-fluoride-stimulated components of beef brain cortex adenylate cyclase cy calcium ions, ethyleneglycol-bis-(beta-aminoethyl ether) N,N'-tetraacetic acid and Triton X-100. | Beef brain cortex adenylate cyclase (ATP pyrophosphate-lyase (cyclizing) EC 4.6.1.1) activity is 84--88% inhibited by 5 - 10(-5) M ethyleneglycol-bis-(beta-aminoethyl ether)N,N'-tetraacetic acid in the absence of F- but only 50--60% inhibited by 5 - 10(-5) M ethyleneglycol-bis-(beta-aminoethyl ether)N,N'-tetraacetic ac... | 167,852 | [
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[IR-spectroscopic study of cytochrome C-phospholipid lipoprotein and proteolipid model membranes]. | It is shown by the methods of IR-spectroscopy and peptide hydrogen-deuterium exchange that a) considerable changes in the protein spectra occur (beta-conformation in the protein structure appears) during the interaction in water of cytochrome c molecules with lipid membranes containing negatively charged polar groups; ... | 167,868 | [
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... |
Iontophoresis of cyclic AMP. | The design, calibration, and operation of a source of controlled amounts of cyclic AMP (c-AMP) are described. Typically, 1.5 s pulses containing 10(10)-10(-12) molecules of c-AMP can be delivered to a region about 10 mum in diameter on an agar plate. The resulting concentration profiles are given as functions of distan... | 167,878 | [
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0.09888034,
... |
The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions. | 1 The effects of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) were investigated on evoked end-plate potentials (e.p.ps) and on miniature end-plate potentials (min. e.p.ps) recorded from muscle fibres of the rat diaphragm and the frog sartorius.2 ATP and ADP decreased the quantum content of the e.p.ps an... | 167,894 | [
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Effect of immunization with attenuated Mycobacterium bovis (BCG) on experimental herpetic keratitis. | Mycobacterium bovis (BCG, Pasteur strain) was injected intraperitoneally into guinea pigs and rabbits on the 19th and 5th days prior to the intracorneal inoculation of Herpesvirus hominis. During a three-day and nine-day observation period, respectively, the BCG had no significant effect on the clinical course of the h... | 167,922 | [
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0.3830377,
0.36851... |
The effect of caesium on adrenergic transmission in rabbit vas deferens. | The effect of caesium on the responses of rabbit vas deferens to transmural stimulation was investigated. The tissue responded to transmural stimulation with a phasic spike contraction followed bya sustained contractile response. The sustained response was inhibited by phentolamine and guanethidine and thus apparently ... | 167,923 | [
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0.1367579,
0.0718184... |
The demonstration of transmissible gastroenteritis viral antigens by immunoelectrophoresis and counterimmunoelectrophoresis. | Immunoelectrophoresis of alkaline intestinal extracts, or the supernatants after precipitation of these extracts with 60% ammonium sulfate, prepared from piglets experimentally infected with the DL or Purdue strains of transmissible gastroenteritis virus, revealed up to three antigens. Two antigens migrated towards the... | 167,926 | [
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-0.080... |
Virus survival on inanimate surfaces. | The persistence of several types of viruses on hard, inanimate surfaces under different relative humidities, temperatures, and types of surfaces was investigated. No differences in survival on glass, vinyl asbestos tile, ceramic tile, and stainless steel were found. Under conditions of low humidity and room temperature... | 167,927 | [
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0.10... |
Changes in lactate dehydrogenase enzyme pattern in Chinese hamster cells infected and transformed with Simian virus 40. | The lactate dehydrogenase (LDH) isozyme patterns of consecutive passages of Chinese hamster embryo cultures were monitored. At early passages the population displayed two LDH bands, M4 and M3H; however, at higher passages the cultures exhibited M2H2, M2H, and M4. When primary cultures of Chinese hamster embryo cells we... | 167,939 | [
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... |
Chemotherapeutic management of bronchogenic carcinoma: trials with NSC-140117, a new methanesulfonic acid ester of aminoglycol. | A new drug, NSC-140117, was used in the management of 15 patients who had late bronchogenic carcinoma and were unable to receive surgical or radiotherapeutic treatment. Good responses in the form of 90% shrinkage in the size of the lesionswere encountered in nine patients (60%). Response is still being maintained from ... | 167,937 | [
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0.1384066,
... |
Cell types in the adenohypophysis of the Japanese quail and effects of injection of luteinizing hormone-releasing hormone. | The cells of the adenohypophysis of the Japanese quail were studied by both light and electron microscopy after exposure to long photoperiods or injection of lutenizing hormone-releasing hormone (LRH). Six cell types were identified in the adenohypophysis by examining alternate thick and thin sections by light and elec... | 167,971 | [
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Effects of cycloheximide on virus RNA replication in an inducible line of polyoma-transformed rat cells. | In this article, we describe two distinct effects of cycloheximide (CH), a potent inhibitior of protein synthesis, on the replication of polyoma virus (PV) DNA in an inducible line of PV-transformed rat cells (LPT cells). Exposure of LPT cells to CH causes up to an 8 fold increase in the cellular concentration of PV DN... | 167,983 | [
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Fibrin overlay methods for the detection of single transformed cells and colonies of transformed cells. | Fibrin overlay methods are described which can detect the plasminogen activator produced by single transformed cells or small colonies of transformed cells. These methods were applied to malignant cells derived from humans, mice, hamsters, rats, and chicks. The lysis observed was plasminogen dependent. Transformation o... | 167,984 | [
0.03126558,
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... |
The inhibitory effect of glucose on the differentiation of trophic Hartmannella culbertsoni into viable cysts. | During encystation of Hartmannella culbertsoni induced by taurine or epinephrine, 60-70% of the reserve glycogen is degraded. Glycogen phosphorylase is activated and glycogen synthetase is inhibited after 6-8 hr of exposure to the encystation medium. The carbon skeleton of glycogen but not that of protein is utilised i... | 167,987 | [
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0.02402871,
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0.4287058,
-0.0934... |
Biochemical anomalies of the nephrotic syndrome. | The nephrotic syndrome is the only hypoalbuminaemic state frequently associated with hyperlipidaemia. In the presence of a negative nitrogen balance, hyperlipidaemia is metabolically inappropriate and reflects the result of persistent breakaway from free fatty acid control. This lipid abnormality may result in the prem... | 168,035 | [
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Adrenal cells in tissue culture the effects of choleragen and ACTH on steroid and cyclic-AMP metabolism. | Primary cultures of mouse adrenocortical tumors provide a sensitive system for investigating the effects of the enterotoxin of the V. cholerae (choleragen) on cyclic-AMP metabolism in the intact cell. Like ACTH, the toxin stimulates the synthesis and release of steroids from these cells but its mode of action differs f... | 168,056 | [
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0.0693048,
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0.1... |
Qualitative abnormality of insulin secretion in a case with insulinoma. | We have presented here a case of atypical insulinoma. Despite the recurrent episodes of hypoglycemic symptoms, the plasma level of insulin has never been excessive at fasting or by regular provocative tests. Detailed examination had demonstrated qualitative abnormality of insulin secretion. Hyposuppressibility of in... | 168,060 | [
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Effects of temperature on interictal discharge at penicillin epileptogenic foci. | The effects of local brain temperature on acute focal penicillin epilepsy in the exposed hippocampus of cat were studied. Results from anesthetized and from immobilized, unanesthetized animals were compared. Over the temperature range 26 to 43 degrees C (at the alveus), the interictal spike interval and duration of the... | 168,063 | [
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0.1150055,
-0.1703678,
-0.0123702,
0.07896667,
0.1112913,
0.08261085,
... |
Deterioration of rat-liver mitochondria during isopycnic centrifugation in an isoosmotic medium. | We have investigated the effect of the centrifugation speed on the behavior of rat-liver mitochondria during isopycnic centrifugation in an isoosmotic medium. The gradient was made with a macromolecular compound, glycogen dissolved in 0.25 M aqueous sucrose. The distribution curves of several mitochondrial enzymes chan... | 168,073 | [
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0.003511394,
0.1063973,
0.6151835,
0.05352574,
0.0958688... |
Blocks in elongation and initiation of protein synthesis induced by interferon treatment in mouse L cells. | Synthesis of polypeptide chains coded by exogenous messenger RNAs is inhibited in cell-free extracts from interferon-treated mouse L cells, due to a "deficiency" in some specific tRNA species. A detailed analysis shows that polypeptide chain elongation is blocked and incomplete chains are formed. After a few minutes, h... | 168,074 | [
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0.5262136,
0.3903876,
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-0.1124732,
... |
Regional and systemic haemodynamic effects of some vasopressins: structural features of the hormone which prolong activity. | Cardiac output and regional blood flows to myocardium, gut, uterus and kidney were determined in anaesthetised female rats by a single injection of 86RbCl. The haemodynamic responses were measured at various time intervals up to 2 h after single I.V. injections of lysine-vasopressin and the following of its analogues: ... | 168,085 | [
0.2144503,
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0.1490968,
0.02244328,
0.03774268,
0.4904909,
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... |
Influence of atropine, metiamide and vagotomy on cAMP of resting and stimulated gastric mucosa. | In normal rats the effect of atropine and metiamide was studied on cAMP levels of resting and histamine-, pentagastrin-, carbachol- and insulin-stimulated gastric mucosa. In vagotomized rats gastric mucosal cAMP levels were investigated under basal conditions and after insulin. Atropine and metiamide did not alter cAMP... | 168,089 | [
-0.04786949,
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0.3377112,
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0.04457541,
0.2435524,
0.03354106,
0.2032643,
... |
ACTH-secreting 'apudoma' of gallbladder. | The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. | 168,130 | [
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0.0861183,
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0.5127952,
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-0.007... |
Adopting new models for continuity of care: the ward as mini-mental-health-center. | Several years ago the staff of a traditional psychiatric ward in a Veterans Administration hospital began trying to provide continual care for their former inpatients after they left the hospital. Nursing assistants conducted basic-skills groups and other groups in board-and-care homes; staff members made themselves av... | 168,144 | [
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0.03309632,
0.1940693,
0.01519867,
0.06... |
Enzyme polymorphisms and haemoglobin variants in Greeks. | Several enzyme polymorphisms and hemoglobin variants were typed in a sample of n = 219 non-related Greek blood-donors. The following gene frequencies were observed: pa = 0.201, pb = 0.701, pc = 0.098;PGDA = 0.985, PGDc = 0.015; AK1 = 0.942, AK2 = 0.058; HbA = 0.988, HbS = 0.012. No polymorphic variation was seen in L... | 168,147 | [
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0.3595825,
0.198969,
0.1258653,
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... |
Heterokaryons in the analysis of genes and gene regulation. | Cytological and chemical analysis of heterokaryons, the immediate product of cell fusion, offer new possibilities for studying the factors responsible for genetic regulation in eukaryotic cells. In comparison with proliferating cell hybrids the heterokaryon state offers the important advantage that a heterokaryon conta... | 168,148 | [
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0.6249225,
0.1206585,
-0.03519088,... |
[Virus propagation, virus replication and virus elimination in the human skin in zoster]. | The purpose of this study was to investigate the spreading, the replication and the elimination of Varicella-Zoster-Virus (ZV) in human skin. Typical skin lesions of thoracic zoster in different stages of development and of exanthematic vesicles in ophthalmic zoster were examined under the electron microscope. We found... | 168,168 | [
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0.3717314,
0.09839407,
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... |
On the effect of N-methyl-bis (3-mesyloxypropyl) amine hydroxychloride on Bacillus subtilis cells. | N-Methyl-bis (3-mesyloxypropyl)amine hydrochloride is now in use as an antitumer drug. In view of its activity against some bacteria the present work was conducted to study its mode of action of Bacillus subtilis. The compound was found to induce irreversible damage to bacterial DNA whereas its effect on RNA was tempor... | 168,172 | [
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0.0001543773,
0.0940882,
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0.2826947,
0.2920217,
0.0007687447,
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... |
Fluorometric measurement of aflatoxin adsorbed on florisil in minicolumns. | Filter fluorometers have been adapted to measure the fluorescence intensity of aflatoxin absorbed on a Florisil layer in minicolumns. The relationship between concentration and intensity is near linear in the aflatoxin range from 10 to 100 ng. Although individual aflatoxin fractions cannot be resolved, since the measur... | 168,177 | [
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0.05615764,
0.4312726,
-0.006704118,
-0.0589... |
Assembly of the mitochondrial membrane system: isolation of nuclear and cytoplasmic mutants of Saccharomyces cerevisiae with specific defects in mitochondrial functions. | A selection procedure is described which permits a large number of Saccharomyces cerevisiae mutants to be screened for specific lesions in mitochondrial respiratory enzymes and the adenosine triphosphatase. The method has been used to isolate nuclear mutant strains with specific lesions in coenzyme QH2-cytochrome c red... | 168,180 | [
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0.6807386,
0.2694336,
0.0003790322... |
Regulation of mitochondrial membrane assembly in Neurospora crassa. Transient expression of a respiratory mutant phenotype. | Cultures of mutant cni-1, a chromosomal mutant of Neurospora crassa, undergo a marked change in respiratory properties as the age of the culture increases. Early log phase cultures have a high level of respiration that is insensitive to inhibition by cyanide or antimycin A. Late log and stationary phase cultures have r... | 168,205 | [
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0.1897226,
0.2872778,
-0.07486293,
... |
A specific cyclic guanosine 3':5'-monophosphate-binding protein in Caulobacter crescentus. | A binding protein specific for cyclic guanosine 3':5'-monophosphate (cyclic GMP) has been partially purified from extracts of the eubacterium Caulobacter crescentus and resolved from cyclic adenosine 3':5'-monophosphate (cyclic AMP)-binding activity. Binding of cyclic GMP is not affected by the addition of cyclic AMP o... | 168,209 | [
-0.2679011,
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0.1597461,
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0.08611632,
-0.053899... |
Enhanced destruction of lymphoid cell lines by peripheral blood leukocytes taken from patients with acute infectious mononucleosis. | The cytotoxicity of peripheral blood leukocytes from normal human donors and from patients with EBV-associated infectious nomonucleosis (IM) has been determined for human lymphoid cell lines (LCL) containing Epstein-Barr virus (EBV) DNA. In a 51Cr release assay, mononuclear leukocytes from all donors are spontaneously ... | 168,255 | [
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0.3738759,
0.5144824,
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-0.07548399,
-... |
Establishment of replicating long-term lines of rabbit macrophages and lymphocytes. | Macrophages (monocyte derived) and lymphocytes have been successfully cultured from rabbit peripheral blood so that replicating long-term cultures are maintained both in media and in the viable, frozen state. The macrophages are considered as such on the basis of phagocytic capabilities, gamma-globulin receptor sites a... | 168,268 | [
0.08738889,
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0.4911695,
0.09624054,
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... |
Taxonomy of the Clostridia: ribosomal ribonucleic acid homologies among the species. | rRNA homologies have been determined on reference strains representing 56 species of Clostridium. Competition experiments using tritium-labelled 23S rRNA were employed. The majority of the species had DNA with 27 to 28% guanine plus cytosine (%GC). These fell into rRNA homology groups I and II, which were well defined,... | 168,308 | [
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0.5367703,
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The terminal autonomic nervous system in the pancreas of newts. Electron microscopic investigations using acetylcholinesterase and zinc iodide-osmium tetroxide reactions. | The intrinsic innervation in the pancreas of newts Triturus vulgaris, Tr. montandoni and Notophthalmus. All the investigated species display: cholinergic innervation better developed than adrenergic, no qualitative differences regarding the fine structure of nerve fibers and terminals as compared to that previously des... | 168,313 | [
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... |
Five seasons of sadness. | In response to her grandmother's death, moving back to her family, and beginning kindergarten, Bridget experienced a very difficult adjustment. During the period of play therapy, she began grief work: "Emancipation from bondage to the deceased, readjustment ot the environment in which the deceased is missing, and forma... | 168,366 | [
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0.1218314,
0.328854,
0.2544793,
-0.177196... |
[A case of carcinoma of the stomach with calcification (author's transl)]. | The authors found only 25 cases of calcified carcinoma of the stomach in the literature. The course in this case was rapidly fatal. Calcification within the tumour infiltrates the gastric wall and has a very characteristic miliary appearance, permitting one to make the diagnosis on a straight X-Ray of the abdomen. The ... | 168,375 | [
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0.4483117,
-0.05236967,
-0.0482714... |
Synthesis and biological activity of 4-beta-Iribofuranosyl-1,3-dihydroxybenzene ("1,3-dideazauridine"). | In view of the marked antitumor activity of 3-deazauridine, the synthesis of 4-(beta-D-ribofuranosyl)-1,3-dihydroxybenzene (1,3-dideazauridine) and its dibenzyl derivative was carried out. 4-Bromo-1,3-dihydroxybenzene was converted to its dibenzyl derivative, which, upon reaction with n-butyllithium followed by treatme... | 168,382 | [
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0.112146,
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0.3609291,
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0.2524377,
0.519973,
0.1642876,
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0.2... |
Association of vesicular stomatitis virus glycoprotein with virion membrane: characterization of the lipophilic tail fragment. | The proteolytic enzyme, thermolysin, degraded the external segment of the membrane glycoprotein of intact vesicular stomatitis (VS) virions but left behind a small nonglycosylated fragment, presumably embedded in the virion membrane. Other proteases generated membrane-associated glycoprotein fragments differing somewha... | 168,400 | [
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0.2234718,
0.1322736,
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0.01871952,
-0.3236121... |
Murine virus susceptibility of cell cultures of mouse, rat, hamster, monkey, and human origin. | Studies were initiated to determine the practicality of using various tissue cultures for the propagation of murine viruses isolated from laboratory animals. The cytopathogenic effects of 10 murine viruses known to cause disease in laboratory rodents were compared in monolayer cultures of L929, BHK-21, WI-38, BSC-1, an... | 168,428 | [
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0.0381427,
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0.2720638,
-0.02392509,
0.09498845,
-0.1561555,
... |
The importance of geographical pathology. | Three different forms of cancer--the Burkitt lymphoma, nasopharyngeal carcinoma and skin cancer--are discussed in their relation to geographical distribution, the possible role of viruses, and genetic predisposition. Certain general conclusions in regard to cancer follow from these discussions. It is stated firmly that... | 168,477 | [
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0.2432804,
0.1177231,
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0.07734904,
0.3941802,
0.4294832,
-0.1933337... |
Liver tumors in women on contraceptive steroids. | The possible association between oral contraceptives and benign liver tumors has recently been reported. To date the majority of cases have been diagnosed as benign hepatomas (liver cell adenomas). We have had the opportunity to study 13 such cases. Eight have been examples of focal nodular hyperplasia of the liver; ho... | 168,523 | [
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0.02892106,
0.3664223,
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0.328403,
0.08800292,
-0.134021... |
Peritonsillolith. | Peritonsillolith appears to be an unknown entity. Two cases of lithiasis in the peritonsillar region following spontaneous rupture of peritonsillar abscesses have been reported. The authors have speculated concerning the cause of stone formation in the peritonsillar region, which has been designated "peritonsillolith,"... | 168,529 | [
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0.09532702,
0.05274358,
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0.198015,
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0.2850484,
-0.05467533,
-0.279791... |
Hormonal control of glucose metabolism. | Glucose homeostasis is accomplished through two major hormones, glucagon and insulin. These hormones, of course, must work in concert with other permissive hormones such as glucocorticoids and catecholamines to bring about a multiplicity of physiological processes such as gluconeogenesis, glycolysis, lipolysis, and pro... | 168,543 | [
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0.2042701,
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0.07112917,
0.02021313,
-0.31217... |
The 5' end group of tobacco mosaic virus RNA is m7G5' ppp5' Gp. | RNA extracted from CsC1-purified virions of tobacco mosaic virus is shown to give rise to an unusual nucleotide on digestion which RNAase T2, in addition to the four major nucleotides. This minor component has the electrophoretic characteristics of a phosphorylated end group, but is partially resistant to bacterial alk... | 168,558 | [
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0.08515386,
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0.2409873,
0.187491,
-0.1260417,
-0.0844323,
-0.29086,
0.06950824,
-0.422161,
0.1809409,
0.4045677,
-0.01935631,
0.3732439,
0.204416,
-0.07907156,
0.... |
Anatomy of herpes simplex virus DNA: strain differences and heterogeneity in the locations of restriction endonuclease cleavage sites. | Digestion of herpes simplex virus DNA by the HinIII or Eco RI restriction endonucleases yielded 11 to 15 fragments with molecular weights between 1 x 10(6) and 28 x10(6). The electrophoretic profiles obtained in 0.3% agarose gels with DNA fragments from none different strains of herpes simplex virus type 1 could be rea... | 168,574 | [
0.2467609,
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0.1655185,
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Interrelationship between poly (ADP-Rib) synthesis, intracellular NAD levels, and muscle or cartilage differentiation from mesodermal cells of embryonic chick limb. | Mesodermal cells of embryonic chick limbs have the capacity to differentiate into either muscle or cartilage. Previous reports from this laboratory show a correlation between pyridine nucleotide levels and this differentiation, and thus suggest that fluctuations in the cellular NAD levels play a role in the control of ... | 168,579 | [
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0.4266241,
0.7269476,
0.02869269,
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-... |
Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules. | Mixing chromatographic fractions containing simian virus 40 (SV40) T antigen with SV40 [3H]-DNA I (double-stranded, circular, supercoiled) results in the conversion of the nucleic acid to a form that will bind to a nitrocellulose filter. Unlabeled SV40 DNA I successfully competes with this reaction. Under the condition... | 168,585 | [
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0.05126641,
0.3904496,
-0.0515529,
-0.266360... |
DES-ASP1--angiotensin II: possible role in mediating responses of the renin-angiotensin system. | In dexamethasone-treated dogs, both antiogensin II and its heptapeptide fragment (des-asp1-angiotensin II) stimulated the secretion of the adrenal steroids aldosterone, corticosterone, and cortisol. Further, there was no statistically significant difference in the steroidogenic potency of the two peptides. An interesti... | 168,589 | [
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-0.2... |
Noradrenergic role in the self-administration of morphine or amphetamine. | The role of brain noradrenergic neurons in mediating the reinforcing properties of small intravenous doses of morphine and d-amphetamine was investigated by pretreatment of rats with the norepinephrine-depleting agents diethyldithiocarbamate and U-14,624, inhibitors of dopamine-beta-hydroxylase (DBH). Such treatment pr... | 168,592 | [
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0.1748959,
0.2622342,
0.1923462,
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0.0... |
Effect of ascorbic acid, sodium salicylate, and caffeine on the serum interferon level in response to viral infection. | The ability of ascorbic acid, sodium salicylate, and caffeine to alter the circulating serum level of interferon was investigated in mice. The animals were singly injected subcutaneously with one of the compounds, 4-8 h later again singly injected intraperitoneally with poly I:C, and bled 6-8 h afterward. The sera from... | 168,598 | [
-0.2884696,
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0.06996157,
0.1848169,
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0.01471882,
0.4917284,
0.286707,
0.04259428,
-0.0603788... |
Reticuloendothelial system function test using 131I-labeled aggregated albumin. | The reticuloendothelial system function test using 131I-labeled aggregated human albumin (131IAA) as test particle is thought to be one of the best methods for the study of RES function of human beings. This method needs a large amount of 131IAA, but 131IAA has been used as a tracer of liver scintiscanning, and we tire... | 168,666 | [
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0.1845668,
0.1664798,
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0.4097922,
-0.04476934... |
[Vacuolisation of odontoblasts and regressive metamorphoses from viewpoint of pulp-dentin system function]. | The authors, after presenting a critical definition of the problems dealt with in their present paper in addition to giving an evaluation there of from the point of view of a constant increase of knowledge, describe the biological functions of the cell with particular reference to the cell's vacuolar apparatus. They th... | 168,700 | [
0.06254555,
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0.2530602,
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-0.2492566,
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0.1567353,
0.1647647,
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0.3451731,
0.2227632,
-0.06292341,
... |
[A new butyric acid-producing bacteroides species: B. splanchnicus n. sp. (author's transl)]. | Three butyric acid-producing saccharolytic Bacteroides cultures (1651/6, BM 158, and IPP 3751) were described by WERNER and REICHERTZ in 1971 (Zbl.Bakt.Hyg., I. Abt. Orig. A 217,206-216). Since then, 6 strains closely resembling 1651/6 were isolated from stool specimens and surgically removed appendices. In the present... | 168,701 | [
0.3270314,
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0.09652036,
0.07424449,
0.08957709,
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0.06919307,
0.2990426,
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0.1007852,
0.2142677,
0.1487882,
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0.1055923,
-0.6513373,
0.2390316,
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0.6326776,
0.124992,
0.08759584,
-0.0001752196,
... |
Effect of beta-propiolactone on infectivity and haemagglutinin of the BK virus. | The effect of beta-propiolactone (BPL) on the infectivity and haemagglutinating properties of BK virus was studied. No virus multiplication was observed when Vero cell cultures were inoculated with virus treated with 0.1 per cent or higher concentration of BPL. On the other hand, treatment of BK virus with 0.1 per cent... | 168,727 | [
-0.1213247,
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0.1255885,
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0.1646207,
0.1785268,
0.2682599,
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0.2243118,
0.04016802,
0.6336543,
0.1699514,
0.1075209,
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-0.08... |
A method fof production or antisera to hepatitis b antigen subtypes, and the distribution of subtypes d and y among norwegian hepatitis b patients. | A method for production of antisera to hepatitis B antigen (HBsAg) subtypes D and Y is described. The method is based on the coupling of HBsAg to a colloidal silica gel (Aerosil), and the selective adsorption of unwanted antibodies from antisera with this preparation. Some results obtained with Norwegian hepatitis pati... | 168,728 | [
-0.1698963,
0.07875738,
0.04171062,
0.2252818,
0.09211781,
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-0.2780731,
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0.2098558,
0.1248925,
0.1923971,
0.3964927,
0.2873103,
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-0.2503462,
-0.1700546,
-0.1636399,
0.2979745,
0.2342539,
-0.133688,
-0.3102592,
... |
Effect of arginine deficiency on the reproduction of human cytomegalovirus. | In arginine-deprived human embryonic fibroblasts the reproduction cycle of human cytomegalovirus (CMV) is incomplete. Infectious virus cannot be demonstrated in cell disintergrates, and from among the CMV antigens only the diffuse cytoplasmic antigen is detectable by immunofluorescence. The antigens localized in the ce... | 168,739 | [
-0.05021692,
0.2429615,
0.0449176,
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0.2800847,
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0.01690131,
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0.3669671,
0.3030124,
0.04466285,
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0.2573304,
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0.1395919,
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0.08550407,
0.3899709,
0.2369783,
-0.1084737,
0.... |
Electroresponsive properties of dendrites in central neurons. | A brief sketch of the historic development of the concept of neuronal integration is given. Some of the properties of dendritic spikes in chromatolyzed motoneurons, alligator Purkinje cells, and fish oculomotor neurons are reviewed, as well as the various ways in which the generation of dendritic spikes has altered our... | 168,752 | [
-0.1548941,
0.005571427,
-0.2728362,
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0.1134011,
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0.1326412,
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0.1102518,
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0.1662486,
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0.3093904,
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0.07520462,
0.2039395,
-0.02995133,
0.21577... |
CNS regulation of metabolic rate in the kangaroo rat Dipodomys ingens. | Water-perfused thermodes were chronically implanted around the preoptic nuclei and hypothalamus (POH) of kangaroo rats (Dipodomys ingens). Responses in rate of metabolic heat production to manipulations of POH temperature (Thy) were measured in unanesthetized, unrestrained animals at ambient temperatures of 10, 20, 25... | 168,786 | [
0.1105276,
-0.4914666,
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-0.1791036,
0.01147112,
-0.4319798,
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0.1799267,
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0.1621405,
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0.1155006,
0.1790003,
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0.4259311,
-0.1317623,
... |
The cost of schizophrenia. | The cost of schizophrenia has been estimated at $11.6 to $19.5 billion annually. About two-thirds of this cost is due to lack of productivity by schizophrenic patients and about one-fifth to treatment costs. The estimate might be considerably higher if better figures were available on the cost of maintaining patients i... | 168,788 | [
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0.3073488,
0.04794061,
0.09208516,
0.4245371,
0.09131768,
0.02346826,
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0.1535123,
0.008830119,
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0.1997417,
0.08450561,
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0.05697456,
0.1552059,
-0.3095219,
-0.2392779,
-0.00489901,
0.2976079,
0.07324821,
... |
Canine adenovirus type 2-induced immunity to two canine adenoviruses in pups with maternal antibody. | Twenty-four Beagle pups with high levels of maternal antibody to canine adenovirus type 1 (CAV-1) and canine adenovirus type 2 (CAV-2) were oronasally inoculated with CAV-2 at 4 weeks of age. The CAV-2 was isolated from pharyngeal swabs on postinoculation days 2 through 6. In spite of the infection, maternal antibody c... | 168,797 | [
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-0.5949956,
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0.09027765,
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0.220716,
0.2477536,
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0.1476575,
0.2030851,
-0.08653955... |
Variations in the activTY OF SOME BRAIN AND PLASMA ENZYMES UNDER THE INFLUENCE OF +Gz acceleration. | The present paper refers to the activity of some enzymes associated with the cellular cytomembranes in the plasma and brain of guinea pigs exposed to the action of repeated +10Gz acceleration. Immediately after the last run, diminution of enzymatic activity in the brain supernate ran parralel to a rise in plasma enzyma... | 168,856 | [
0.01617606,
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0.1915191,
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-0.04993134,
0.08894286,
0.2390032,
0.1908091,
0.1487946,
-0.07247767,
... |
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