title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Occurrence of duck virus enteritis (duck plague) in Pennsylvania, 1968-74. | During the 7-year period 1968-74 cases of duck virus enteritis (duck plague) were diagnosed in waterfowl in Pennsylvania. Muscovy ducks were affected in 8 cases, geese in 3 cases, and mallard ducks in 1 case. In 5 of these cases either domestic or wild ducks were closely associated with infected waterfowl but were unaf... | 168,855 | [
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The altered specificity of cortisone reductase with certain retroandrostan-3-one substrates. | The retro steroids 17beta-hydroxy-5beta,9beta,10alpha-androstan-3-one and 5beta,9beta,10alpha-androstane-3,17-dione were good substrates for cortisone reductase in the presence of NADH, and the products corresponded to the respective 3beta-hydroxy compounds, in which the 3beta-hydroxyl group is axial and the absolute c... | 168,869 | [
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Evidence for a histidine and a cysteine residue in the substrate-binding site of yeast alcohol dehydrogenase. | 1. Yeast alcohol dehydrogenase (EC 1.1.1.1) is inhibited by stoicheiometric concentrations of diethyl pyrocarbonate. The inhibition is due to the acylation of a single histidine residue/monomer (mol.wt. 36000). 2. Alcohol dehydrogenase is also inhibited by stoicheiometric amounts of 5,5'-dithiobis-(2-nitrobenzoate), ow... | 168,872 | [
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High affinity oestradiol receptors and the activity of glucose-6-phosphate dehydrogenase and lactose synthetase in mammary carcinomata of postmenopausal women. | The determination of hormone inducible proteins in endocrine tumours may yield information about the presence of hormone dependent tumour cells. We have estimated the high affinity oestradiol binding capacity in primary mammary carcinomata of 57 postmenopausal patients. Glucose-6-phosphate dehydrogenase and lactose syn... | 168,914 | [
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Prostaglandins and cyclic AMP in epidermis. Evidence for the independent action of prostaglandins and adrenaline on the adenyl cyclase system of pig and human epidermis, normal and psoriatic. | Prostaglandins E1 and E2 stimulate cyclic AMP accumulation in pig epidermis and in human epidermis from patients with psoriasis. Prostaglandins A1,A2 and F2alpha are relatively ineffective. The fact that this stimulation is not inhibited by a beta-blocker (propranolol) and that the stimulation by prostaglandin E2 and a... | 168,916 | [
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Laser-flash-activated electron paramagnetic resonance studies of primary photochemical reactions in chloroplasts. | Electron paramagnetic resonance studies of the primary reactants of Photosystems I and II have been conducted at cryogenic temperatures after laser-flash activation with monochromatic light.P-700 photooxidation occurs irreversibly in chloroplasts and in Photosystem I fragments after activation with a 730 nm laser flash... | 168,921 | [
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Two forms of a mitochondrial endonuclease in Neurospora crassa. | Mitochondrial nuclease activity in Neurospora crassa occurs in membrane-bound and soluble forms in approximately equal proportions. These activities apparently are due to the same enzyme, which has an approximate molecular weight of 120 000. A portion of the insoluble enzyme appears to be associated with the inner mito... | 168,950 | [
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Pancreatic neoplasms in an animal model: morphological, biological, and comparative studies. | After a short latency (15 weeks), a 100% incidence of pancreatic neoplasms was induced in Syrian golden hamsters, following the administration of 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN). Data extracted from reports of human pancreatic neoplasms were compared with findings relative to the induced neoplasms. The lat... | 168,955 | [
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Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. | A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not. In the present experiments, 95% or more of cells obtained from primary hepatocellular carcinomas which resulted from exposure of rats to N-2-fluor... | 168,971 | [
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[Induction of cutaneous or subcutaneous fibroblastic tumors in the Afghan pika (Ochotona rufescens rufescens) by injection or bovine papilloma virus]. | Newborn Afghan pikas have been inoculated with bovine papilloma virus via the subcutaneous route. Cutaneous or subcutaneous fibromas and fibrosarcomas were observed after a mean incubation period of nine months. The transmission of these tumors by homograft has been obtained. Bovine papilloma virus antibodies have been... | 168,982 | [
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[RNA fragments, in vivo inhibitors of Shope fibroma and vaccinia virus multiplication]. | RNA-fragments rich in purine nucleotides and resulting from degradation of ribosomal RNA from E. coli M 500 Sho-R with pancreatic RNase exhibit only in vivo an inhibitory effect on Shope fibroma and vaccinia virus multiplication. | 168,984 | [
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Electron microscopic observations of 20 human osteosarcomas. | Twenty primary osteosarcomas of bone and two osteosarcomas metastatic to the lung were examined by electron microscopy. The tumor cells, whether from an area exhibiting chondroid, osteoid or collagenous matrix, showed common abnormalities in configuration and fine structure. The cells tended to be spindle-shaped with c... | 169,000 | [
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AMV RNA transcription in cell-free systems and properties of in vitro chromatin-directed RNA synthesis. | In this report we have presented evidence that viral sequences in the genome of AMV-infected myeloblasts can be transcribed in vitro. The RNA products synthesized in either nuclei isolated from these cells or by eukaryotic RNA polymerase B from the isolated chromatin contained approximately 1% virus-specific sequences.... | 169,005 | [
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Qualitative and quantitative studies of AKR-type murine leukemia virus sequences in mouse DNA. | Utilizing a single-stranded [3H]DNA probe highly representative of AKR viral 70S RNA, we have performed association kinetics experiments with cellular DNA in vast excess from 3 high-, 5 low- and 4 non-virus-yielding mouse strains. Our hybridization studies indicate that in the strains so far tested, the complete genome... | 169,010 | [
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Studies of hamster cells transformed by adenovirus 2 and the nondefective Ad2-SV40 hybrids. | Adenovirus 2 does not produce tumors when injected into newborn hamsters, and this failure is not corrected by the acquisition of the portion of the SV40 genome present in any of the nondefective Ad2-SV40 hybrid viruses. However, nonhybrid Ad2 will transform hamster cells in vitro, and these transformed cells will prod... | 169,097 | [
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Characterization of defective simian virus 40 DNA: comparison between large-plaque and small-plaque types. | We characterized defective DNA molecules of large-plaque and small-plaque SV40 produced and accumulated during serial undiluted passages. The electron microscope heteroduplex method revealed that defective SV40 DNA contains deletions, insertions and substitutions. The majority of the large-plaque defective molecules ha... | 169,099 | [
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Fibrous histiocytoma of the trachea. | A histologically benign but locally infiltrating tumor of histiocytes, fibrous histiocytoma, was found in the trachea of a 26-year-old man. Partial resection of the trachea afforded the successful removal of the growth with no evidence of recurrence or metastases 27 months after surgery. Pathology and prognostic aspect... | 169,106 | [
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[Carcinoma of the liver in a child after seven-year complete remission of acute lymphoblastic leukaemia(author's transl)]. | A malignant hepatoma occurred in a 12-year-old girl who eight years previously had developed an acute lymphoblastic leukaemia which for eight years had been in complete haematological remission. Fourteen months after the last re-induction treatment period had been discontinued, but while on methotrexate and 6-mercaptop... | 169,114 | [
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Antibodies to Epstein-Barr virus in subacute sclerosing panencephalitis patients. | Blood samples from 45 cases of subacute sclerosing panencephalitis in Israel were tested for the presence of antibodies to Epstein-Barr virus capsid antigen and early antigen by the indirect immunofluorescence method. Significantly higher titers were found in patients as compared to healthy controls with higher titers ... | 169,130 | [
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Correlation of estrogen-induced uterine eosinophilia with other parameters of estrogen stimulation, produced with estradiol-17beta and estriol. | Estradiol-17beta is a stronger estrogen than estriol for the genomic response of estrogens. Estriol is a stronger estrogen than estradiol-17beta for the estrogen-induced uterine eosinophilia and the 6 h increase in the uterine wet weight. | 169,148 | [
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On the pathogenesis of duchenne muscular dystrophy. | The relative merits of the three presently most active hypotheses (vascular, neurogenic, and myogenic) concerning the pathogenesis of Duchenne muscular dystrophy are analysed and discussed and the literature is comprehensively reviewed. | 169,179 | [
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[Effect of [ethyl p-(6-guanidinohexanoyloxy)benzoate] methanesulfonate (FOY) on kinin formation and fibrinolysis activity]. | Inibitory effects of [Ethyl p-(6-guanidinohexanoyloxy)benzoate] methanesulfonate (FOY) on kinin formation (in vitro and in vivo) and the fibrinolytic activity (in vivo) were examined and compared with otherinhibitors. Inhibitory effect on kinin forming activity (in vitro) of various enzymes was measured in the guinea p... | 169,189 | [
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Sensitive assay for detection of toxin-induced damage to the cytoplasmic membrane of human diploid fibroblasts. | A sensitive assay was developed for detection and quantitation of subtle permeability changes in the cytoplasmic membrane of human diploid fibroblasts. Release of the non-metabolizable amino acid [1-14C]alpha-aminoisobutyric acid (AIB; molecular weight (103) from the cytoplasm of prelabeled cells was used as an indicat... | 169,201 | [
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Pyrimidine biosynthetic pathway of Baccillus subtilis. | Biochemical and genetic data were obtained from a series of 51 Pyr- strains of Bacillus subtilis. The observed enzymatic deficiencies allowed the mutants to be placed into 12 clases, some of which represent defects in more than one of the six known pyrimidine biosynthetic enzymes. Mapping analysis by transformation has... | 169,225 | [
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Kinetics of the onset of catabolite repression in Escherichia coli as determined by lac messenger ribonucleic acid initiations and intracellular cyclic adenosine 3',5'-monophosphate levels. | The rates of synthesis of beta-galactosidase (EC 3.2.1.23) and the intracellular levels of cyclic 3',5'-adenosine monophosphate (cAMP) soon after the addition of glucose or glycerol to exponentially growing cultures of Escherichia coli have been determined. Within 10 s of its addition, glucose, but not glycerol, lowere... | 169,231 | [
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Increase in numbers of gonadotropin receptors on granulosa cells during follicle maturation. | The binding of both human chorionic gonadotropin (hCG) and human luteinizing hormone (hLH) to a homogeneous population of isolated intact granulosa cells from increasingly mature porcine ovaan follicles has been studied. The number of receptor sites per granulosa cell increases 35-fold as the follicle enlarges, althoug... | 169,290 | [
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Insulin receptor deficiency in genetic and acquired obesity. | We have previously shown that in the insulin-resistant obese hyperglycemic mouse (ob/ob) there is a deficiency in the number of insulin receptor sites on hepatocytes, adipocytes, and thymic lymphocytes. We now find that concentration of insulin receptors on liver plasma membranes is decreased in the db/db mouse, anothe... | 169,296 | [
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Effect of Klebsiella pneumoniae enterotoxin on intestinal transport in the rat. | The effects on intestinal transport of either a semipurified preparation of enterotoxin elaborated by Klebsiella pneumoniae or similaryly prepared control material were tested by marker perfusion studies in the small intestine of rats. At a concentration of 2 mg/ml, the enterotoxin produced net secretion of water, Na, ... | 169,297 | [
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Varicella-Zoster Immunoglobulins during Varicella, Latency, and Zoster. | Antibodies to membrane antigens of cells infected by varicella-zoster virus were detected by immunofluorescence. Rises in varicella-zoster IgA, IgG, and tigM were detected after both varicella and zoster. Prompt antibody responses were observed in patients with generalized zoster as well as in those with localized zost... | 169,308 | [
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... |
Immunofluorescent staining for the measurement of antibodies to Herpesvirus hominis. | Frozen sections of Herpesvirus hominis-inoculated mouse brain provide excellent antigens for indirect immunofluorescent staining of antibodies to H. hominis in serum. Indirect immunofluorescent staining is a rapid, sensitive, and reproducible method for the measurement of antibodies to H. hominis. The method can be app... | 169,313 | [
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0.1584496,
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... |
Demonstration of enzymes related to myelinogenesis in established human brain cell cultures. | CNP, CGalT and PAPS-CST, enzymes involved in myelinogenesis were demonstrated in cultures derived from human brain. Little or no CNP activity could be found in cultures derived from non-neurogenic tissue. Transformation of brain cultures by PML-SV40 virus resulted in a 3 to 10-fold increase in the specific activity of ... | 169,328 | [
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0.08438934,
0.0586486,
0.007107884,
-0.048928... |
Regulation of seminiferous tubular function by FSH and androgen. | Seminiferous tubules contain a cytoplasmic androgen receptor similar to the receptors in the epididymis and ventral prostate. The presence of a cytoplasmic receptor indicates that androgens maintain spermatogenesis by a direct action on certain types of cells within the seminiferous tubule. The Sertoli cell appears to ... | 169,349 | [
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Malignant tumors in American black and Nigerian children: a comparative study. | Results of a study on the relative frequencies of tumors in American black and Nigerian children were compared with data from the Childhood Cancer Registries in Manchester, United Kingdom, and Kampala, Uganda. The American black child living in Washington, D.C. and the Caucasian child living in Manchester had similar h... | 169,371 | [
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0.399641,
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0.3260... |
Escherichia coli capsule bacteriophages. IV. Primary structure of the bacteriophage 29 receptor, the E. coli serotype 29 capsular polysaccharide. | Using periodate oxidation, methylation analysis, characterization of oligosaccharides by Smith degradation or partial acid hydrolysis, as well as proton magnetic resonance, the primary structure of the Escherichia coli serotype 29 capsular polysaccharide (the receptor of E. coli K phage 29) was reinvestigated. The poly... | 169,391 | [
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... |
Loss of epinephrine stimulated synthesis of cyclic adenosine 3':5' monophosphate during maturation of rabbit and human reticulocytes. | The adenylate cyclase activity of rabbit reticulocytes is localized in the stroma. Rabbit reticulocytes are four times more active than mature erythrocytes in transforming in situ formed [14C] adenosine triphosphate into [14C] cyclic adenosine 3':5'-monophosphate. Similarly, anaemic human red blood cells show higher ac... | 169,441 | [
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0.3223872,
0.306057,
0.1503098,
-0.05027... |
Role of cytidine triphosphate and cytidine diphosphate in promoting inositol entry into microsomal phosphatidylinositol. | The Mn2+ activated incorporation of myo-inositol-3H into subfractions of phosphatidylinositol in rat liver microsomes was studied in the presence and absence of cytidine triphosphate or cytidine diphosphate choline using phosphate buffer. The distribution of labeled inositol among molecular species of microsomal phosph... | 169,452 | [
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0.2958508,
0.3683413,
0.3460532,
0.2478782,
0... |
[NAD-dependent N-methylglutamate dehydrogenase--new enzyme metabolizing methylamine in methylotrophs]. | The properties of N-methylglutamate dehydrogenase, a new enzyme of methylamine metabolism in a facultative methylotroph Pseudomonas methylica, strain 2, were investigated. The enzyme was strictly dependent on the NAD presence and was not connected with particles in cell-free preparations. The enzyme appeared to be incu... | 169,456 | [
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[Translation of hormone receptor interactions into biological function. A hypothesis (author's transl)]. | Published data revealing discrepancies between the kinetics of hormone binding and adenylate cyclase activation are critically analyzed. This analysis gave rise to the hypothesis concerning the translation of hormone receptor interactions into biological function, i.e.: adenylate cyclase activation. Because the lifetim... | 169,465 | [
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0.2050739,
0.4990353,
0.05900337,
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Polypeptides isolated from ribosome-like structures occluded in avian myeloblastosis virus (AMV). | The protein composititon of ribosome-like particles isolated from AMV was determined by acrylamide gel electrophoresis and by immunological methods. It was established that the protein spectrum of ribosome-like particles differed significantly form the total protein spectrum of AMV. The most characteristic protein comp... | 169,489 | [
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0.02004337,
0.4272385,
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0.09... |
Vinblastine-induced ultrastructural changes in perisinusoidal cells of the rat liver. | Vinblastine, given intravenously to rats, leads to disappearance of microtubules, formation of paracrystalline inclusions and accumulation of fat droplets in the cytoplasm of the perisinusoidal cells of the liver suggesting that microtubules of the perisinusoidal cells play a role in lipid metabolism. | 169,558 | [
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0.1084657,
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[Relative increase and metacritic aggravation in the diagnosis of anicteric cholestasis]. | The authors report 3 cases and report the diagnostic usefulness of two signs of minor cholestasis described by one of them in 1966. A relative increase, in the absence of obvious virus hepatitis or cirrhosis, of the serum bilirubin, cholesterol, lipids and alkaline phosphatase, together with B.S.P. excretion. suggest m... | 169,583 | [
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0.376534,
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... |
[Abnormalities of lumbar transverse processes]. | The transverse processes of the lumbar vertebrae sometimes present rare abnormalities, or major abnormalities, which may be contrasted with congenital lesions concerning their volume, shape and direction. After a rapid review of the general and clinical characteristics, radiological analysis of the 59 cases collected i... | 169,585 | [
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0.07546258,
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0.1344291,
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... |
[Anti-nuclear antibodies in collagen diseases]. | The authors sought serum antinuclear antibodies by the indirect immunofluorescent method in 3,260 patients, and found these antibodies in 293 of them. 90 patients had a level equal or greater than 1/50. Among the latter, 54 had some form of collagen disease. The following facts are emphasized: -- antinuclear antibodies... | 169,588 | [
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... |
Serologic studies of acute respiratory infections in military personnel. | The advantages, disadvantages, and uses of serological epidemiology are discussed in relation to acute respiratory infections in military personnel. The prevalence of antibody reflects both current and past experience with respiratory agents and is a measure of susceptinility. Incidence data calculated by testing two... | 169,640 | [
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... |
[Dermatoglyphics in children with embryonic tumors (author's transl)]. | Dermatoglyphics were analyzed in 60 children with embryonic tumors. In comparison with normal children, several differences were found. Thus, the embryonal origin of the different tumors is underlined and the hypothesis of embryonic tumors as malformations is sustained. These tumors seem to be the clinically most im... | 169,641 | [
0.06004971,
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Histochemical localization of enzyme activity in the kidneys of male marmosets (Callithrix jacchus and Callithrix penicillata). | The distribution of several hydrolases and oxidoreductases was studied in the renal parenchyma of adult male marmosets (Callithrix jacchus and Callithrix penicillata). The oxidative enzymes showed a high reactivity in the proximal and distal tubules, whereas the hydrolases reacted strongly in the proximal tubules but o... | 169,663 | [
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[Necrotizing herpetic encephalitis. Electro-clinical and pathological studies on two infantile cases (author's transl)]. | The electroclinical and pathological features of two infantile cases of acute necrotizing herpetic encephalitis are reported. The distribution of the lesions has been compared with those observed in fourteen other cases including four with EEG records. Various electroencephalographic features have been recorded includi... | 169,665 | [
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Preparation of single cell suspensions from hepatoma cells in culture. | Fundamental examination was carried out on the liberation of single cells from hepatoma cells in culture. dRLa-74 cells derived from rat hepatoma, which hardly disperse as single cell suspensions with several proteolytic enzymes or EDTA alone, dispersed with a high yield of single cells by the combination of trypsin an... | 169,672 | [
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0.47... |
On the function of sleep. | It is proposed that sleep serves the function of maintaining immobility in animals at times when immobility is an optimum behavioural survival strategem. Sleep is of great evolutionary age and is always carefully tailored to the life-style of each animal; abundant in some species and absent from others. The survival ad... | 169,715 | [
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Detection of agents that alter the bacterial cell surface. | Proteus mirabilis is not killed by polymyxin B, normal serum, or sodium deoxycholate. Exposure to polymyxin B renders the cells susceptible to killing by the latter two agents. The data suggest that this synergism is due to polymyxin B-induced surface changes. The results point out an inadequacy of existing methods of ... | 169,728 | [
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0.1262237,... |
The prediction of hormonal dependency of mammary cancer. | The estrogen receptor protein (estrophilin) was determined in specimens from 359 primary breast cancers and from metastatic tumors of 214 patients. Ninety-eight patients were eventually treated by some form of endocrine therapy: 82 patients were treated by ablative therapy, and 16 by hormonal additive treatment. The re... | 169,754 | [
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0.1747494,
-0.1507577... |
The sterilization of gutta-percha points. | The traditional methods employed for the sterilization of gutta-percha points are unsatisfactory. The use of propylene oxide for this purpose is described and experimental evidence is advanced to support this use. | 169,776 | [
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0.1477607,
0.2308416,
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... |
Type V hyperlipoproteinaemia re-visted: findings in a sydney population. | The clinical and biochemical features of eleven patients with Type V hyperlipoproteinaemia have been reviewed. All patients were male, and there was a high incidence in the group of obesity, vascular disease, acute abdominal pain, gout, diabetes mellitus and alcoholism. Plasma cholesterol concentrations ranged from 2... | 169,779 | [
0.3112647,
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0.1846673,
0.01442886,
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-0.3209651,
0.242... |
Bluetongue in sheep and goats. | A description is given of the symptomatology, pathology and pathogenesis of bluetongue in sheep and goats. The economic significance of the disease in South Africa is discussed. | 169,785 | [
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0.4369862,
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Epizootiology of bluetongue: the situation in the United States of America. | Bluetongue was first reported in the United States in 1948 in sheep in Texas. The virus has now been isolated from sheep in 19 States. When the disease first occurs in a flock, the morbidity may reach 50 to 75% and mortality 20 to 50%. In subsequent years, the morbidity may be only 1 to 2% with very few deaths. Differe... | 169,793 | [
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-0.3643602,
... |
Rous sarcoma regression in chickens resistant or susceptible to Marek's disease. | In 4 experiments, strains of chickens relatively susceptible (S-strain, P-line) or resistant (N-line, PDRC) to Marek's disease (MD) were challenged with Rous sarcoma virus (RSV) at 6-8 weeks old. RSV tumors occurred in 94-100% of the birds in each strain, but the number with tumors that regressed during the 40-46-day e... | 169,801 | [
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-... |
Avian encephalomyelitis virus in chicken pancreatic cell cultures. | Monolayer cell cultures consisting of epithelioid cells were made from pancreatic tissue of 10-to-13-day-old chicks. The maximum virus titer of the cell-culture fluid was obtained 8 days after inoculation with an embryo-adapted avian encephalomyelitis virus (AEV). Virus titers also increased in cell cultures inoculated... | 169,803 | [
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... |
Comparisons of surface markers on Herpesvirus-associated lymphoid cells of nonhuman primates and established human lymphoid cell lines. | Herpesvirus saimiri (HVS)-owl monkey lymphoid cells were found to have high levels of surface receptor for sheep erythrocytes and erythrocytes of 3 other species. These HVS-lymphoid cells lacked a receptor for modified complement. Lymphoid cells of one HVS-owl monkey line showed evidence for the presence of surface imm... | 169,815 | [
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In vivo interactions between murine leukemia and sarcoma viruses. | Experiments have been performed with the aim of elucidating the nature and the extent of the in vivo interactions between murine leukemia viruses (MuLVs) and murine sarcoma virus (MSV). BALB/c and CBA mice, injected neonatally with Graffi or passage A Gross viruses (MuLV-Gi, MuLV-G), have been inoculated as young adult... | 169,829 | [
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0.6044129,
0.3880973,
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Methanol extraction residue of BCG in the treatment of transplanted rat tumours. | Subcutaneous growth of immunogenic chemically induced rat sarcomata and a hepatoma was restricted when cells were injected into syngeneic animals in admixture with MER. Rats rejecting mixed inocula were immune to further challenge with the same tumour. Growth of a chemically induced mammary carcinoma which lacks detect... | 169,861 | [
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-... |
Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo. | Thirty-two scirrhous cancers of breast have been examined to determine the origin of the collagen stroma in these tumours. Employing two immunohistochemical techniques it has been shown that the malignant epithelial cells in 30 of these tumours contain not only collagen but also prolyl hydroxylase, a key enzyme in coll... | 169,865 | [
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... |
Collagenase and other proteinases in the cornea of the retinol-deficient rat. | 1. Enzymes that may contribute to liquefaction of the cornea in retinol-deficient animals and in man have been studied using rat cornea. The established technique of culturing tissue fragments and determining the activity of collagenase (EC 3-4-24-3) and other enzymes in the medium after different periods of culture wa... | 169,877 | [
-0.03033331,
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0.2581829,
0.2153773,
0.2088033,
0.01595825,
... |
Chlorophyll radical cation in photosystem II of chloroplasts. Millisecond decay at low temperature. | We compare the absorption changes, in the near infrared and in the green part of the spectrum, induced in spinach chloroplasts suspensions, at -- 170 degrees C, by continuous light and by flashes. (1) Following flash excitation, an absorption increase peaking at 825 nm which reverses rapidly (t 1/2 = 3.0 ms) is not aff... | 169,899 | [
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0.4655936,
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Effect of ascorbic acid on ACTH-induced cyclic AMP formation and steroidogenesis in isolated adrenal cells of vitamin E-deficient rats. | Isolated adrenal cells from Vitamin E-deficient and control rats were prepared by a trypsin digestion method. Cyclic adenosine 3',5'-monophosphate (cyclic AMP) formation was studied in response to adrenocorticotropin (ACTH) in the presence and absence of ascorbate by measuring the conversion of prelabeled adenosine 5'-... | 169,901 | [
-0.2755309,
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0.1490778,
0.4143891,
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... |
Hypnosis and eye movements. | Eye movements (with closed lids) were studied in a group of highly hypnotizable experimental subjects experienced in self-hypnosis, and compared with a random sample of control subjects that had never been hypnotized and were low in waking suggestibility. Approximately half the experimental subjects rolled their eyes u... | 169,921 | [
-0.3643042,
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... |
An inhibitory effect of atropine on responses of the vas deferens of the mouse to field stimulation. | 1 Atropine is shown to impair responses of the vas deferens of the mouse to field stimulation by acting at a site proximal to the smooth muscle cells. 2 The inhibitory effect of atropine is prevented by desmethylimipramine and reversed by dexamphetamine, and appears similar to the adrenergic-neurone blockade of guaneth... | 169,932 | [
-0.3474462,
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0.04723692,
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0.01256996,... |
Viral susceptibility of a cell line derived from the pig oviduct. | Seventeen of 24 RNA viruses and eight of nine DNA viruses replicated in a cell line derived from a pig fallopian tube. The following RNA viruses grew poorly in it: the virus of transmissible gastroenteritis of pig and the swine-influenza, Sendai and bovine para-influenza type 3 viruses. Among other RNA viruses an untyp... | 169,971 | [
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0.0301808,
0.1351345,
0.1682572,
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An outbreak of avian encephalomyelitis in turkeys in Canada. | An outbreak of avian encephalomyelitis in two week old turkey poults is described. The disease was diagnosed by the fluorescent antibody technique and was confirmed by neutralization tests conducted in chicks. | 169,973 | [
-0.003109738,
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0.08540711,
... |
Herpes simplex encephalitis in Hodgkins disease. Isolation of drug-sensitive virus from brain following unsuccessful treatment with idoxuridine. | Herpes simplex encephalitis developed in a patient with Hodgkin's disease under therapy. Despite treatment with idoxuridine in a total dose of 280 mg/kg intravenously, he died without showing any clinical response. At autopsy, there was no gross or microscopic evidence of Hodgkin's disease, and virus isolated from the ... | 169,986 | [
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0.2138667,
0.1603457,
0.1674169,
0.1141901,
0.21433... |
Ultrastructure of human bronchiolo-alveolar cell carcinoma. | Ultrastructural features were correlated with a series of special staining reactions in eight cases of bronchiolo-alveolar carcinoma. Ultrastructural, all tumors were similarly composed of large cells with abundant cytoplasm and small nuclei in close contact with each other. Straight membranes or complex interdigitatio... | 169,987 | [
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0.3982178,
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0.1837849,
-... |
Noninvasive quantitation of myocardial infarction with technetium 99m pyrophosphate. | We sought to quantitate infarct size using radioactive imaging techniques. Infarcts were created in closed chest dogs. Using a scintillation camera interfaced to a computer, infarct images were made in the anterior, left lateral, LAO, and RAO projections, 48 hours after infarction and 75 to 90 min following the intrave... | 170,018 | [
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0.2035326,
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0.08954069,
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-... |
[Ultrastructural observations of the velamentous astrocyte impregnated by Golgi's method]. | Electron microscopy of the velamentous astrocyte in the cat inferior colliculus was performed on serial semi-thin and ultra-thin Golgi preparations. The glial origin of the velum has been considered and its topographical relationships with the other structures of the neuropile have been described. | 170,015 | [
-0.1208377,
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0.2546017,
0.1393424,
... |
Detection of inborn errors of metabolism. IV. Galactokinase deficiency. | Galactokinase deficient fibroblasts are not distinguishable from galactosemic fibroblasts by a test suggested earlier by Hill & Puck (1973). They can be so distinguished by the test described here, since they are unable to incorporate radioactive galactose into TCA-insoluble material under normal conditions of incu... | 170,030 | [
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0.2842854,
0.1758715,
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... |
Oxidation of reduced nicotinamide adenine dinucleotide by particles from Mycobacterium lepraemurium. | Particles from Mycobacterium lepraemurium catalysed the oxidation of NADH with oxygen as the terminal electron acceptor. The preparations contained cytochromes of the a + a3'b and c types, as well as CO-binding pigments. The NADH oxidase activity was sensitive to inhibitors of the flavoprotein system as well as to HQNO... | 170,040 | [
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0.1182451,
0.2524673,
0.121494,
0.08918586,
0.0... |
Prevention of acute pulmonary edema during isolated perfusion for 24 hours. | Fifty-nine canine lungs were perfused with cryoprecipitated plasma, silica gel fraction, or modified silica gel fraction (MSGF) af different perfusate pressures for periods up to 24 hours under hypothermic conditions. High perfusate pressures accounted for all poor perfusion results. The use of MSGF at a low perfusate ... | 170,043 | [
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0.00148115,
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0.1555924,
0.03556341,
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0.16804,
-0.1458646... |
The volume and DNA content of extrachromosomal inclusions in the dorsal foot-pad nuclei of Tricholioproctia impatiens (Sarcophagidae, Diptera). | The chromosomes of the giant dorsal foot-pad cells of Tricholioproctia impatiens produce numerous extrachromosomal bodies which consist of a central spherical core of DNA surrounded by a ribonucleoprotein layer. The bodies are either free within the nucleoplasm or attached by thin threads of chromatin to chromosomal ba... | 170,048 | [
-0.09093373,
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0.03129822,
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0.1107463,
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... |
Demonstration of a specific receptor for prolactin in porcine granulosa cells. | Porcine granulosa cells and subcellular fractions from these cells have been shown to have a specific receptor for ovine prolactin (OPRL). Ovine growth hormone demonstrated 7% of the potency of OPRL in displacing 125I-OPRL from its binding site; FSH, TSH, LH, insulin and ACTH showed negligible cross-reactivity. Scatcha... | 170,061 | [
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0.1135156,
0.1914968,
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... |
Autoradiographic localization of corticosterone receptors (type III) to the collecting tubule of the rat kidney. | Recently, a class of receptors exhibiting high affinity for corticosterone was described in rat kidney (Feldman, D. et al., Endocrinology 92: 1429, 1973). These receptor sites exhibited negligible affinity for dexamethasone and aldosterone and were designated Type III to distinguish them from sites having high affinity... | 170,062 | [
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0.5200482,
0.2753015,
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0.01... |
On the mechanism of prolactin and estrogen action in 7,12 dimethylbenz(A)anthracene-induced mammary carcinoma in the rat. II. In vivo tumor responses and estrogen receptor. | In order to test the in vivo effect of prolactin on estrogen receptor (ER) binding capacity in tumors induced by 7,12 dimethylbenz(a)anthrancene (DMBA-tumor), growth of the tumors from changes in prolactin and estrogen levels was compared retrospectively with cytoplasmic ER levels. It was demonstrated that some tumors ... | 170,065 | [
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0.09696347,
-0.... |
Influence of thyroid hormone on glycogen metabolism in rat liver. | The livers removed from thyroidectomized and L-T4 supplemented rats were rapidly frozen by Freon-12 chilled with liquid nitrogen, and concentrations of metabolites which affect glycogen synthetase and phosphorylase were determined. Serum and liver glycose levels were not changed in any thyroid functioning. But liver G6... | 170,073 | [
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0.1018999,
0.2979231,
0.341024,
0.1717052,
-0.5313781,
0... |
Respiratory effects in toluene diisocyanate manufacture: a multidisciplinary approach. | A new plant manufacturing toluene diisocyanate (TDI) has provided a unique opportunity to investigate the effects of TDI vapor inhalation on respiratory health in a group of exposed workers who have been studied prior to the start of plant operation. In order to establish dose-response relationships and determine host ... | 170,075 | [
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0.2751873,
0.04556732,
0.5471498,
-0.09818793,... |
N-acetylglutamate 5-phosphotransferase of Pseudomonas aeruginosa. Purification and ligand-directed association-dissociation. | N-Acetylglutamate 5-phosphotransferase (ATP: N-acetyl-L-glutamate 5-phosphotransferase EC 2.7.2.8), the second enzyme of arginine biosynthesis, was purified over 2000-fold from Pseudomonas aeruginosa. The purification procedure involved a heat treatment, ammonium sulfate precipitation, and chromatography on DEAE-cellul... | 170,089 | [
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0.1974266,
0.4649879,
0.1179424,
-0.1804... |
Purification of rheumatoid synovial collagenase and its action on soluble and insoluble collagen. | 1. The neutral collagenase released into the culture medium by explants of ehrumatoid synovial tissue has been purified by ultrafiltration and column chromatography, utilising Sephadex G-200, Sephadex QAE A-50 and Sephadex G-100 superfine. 2. The final collagenase preparation had a specific activity against thermally r... | 170,094 | [
-0.269192,
-0.2182871,
-0.01416084,
0.1703707,
-0.5443895,
-0.2125896,
-0.2581303,
0.006774609,
0.2622723,
0.1204652,
-0.07380406,
0.4007094,
0.04046819,
0.02011171,
-0.08510922,
0.2855835,
-0.4701886,
-0.02615406,
0.006984816,
0.2776364,
0.3487606,
0.11005,
0.05002195,
... |
Study of coenzyme binding site of octopine dehydrogenase using analogues of NAD+. | The binding of the coenzyme to octopine dehydrogenase was investigated by kinetic and spectroscopic studies using different analogues of NAD+. The analogues employed were fragments of the coenzyme molecule and dinucleotides modified on the purine or the pyridine ring. The binding of ADPribose is sufficient to induce lo... | 170,100 | [
-0.2941481,
0.1140794,
-0.00133269,
0.1225588,
0.03063765,
-0.1388863,
-0.09477989,
0.2113266,
0.08715639,
0.156294,
-0.06613507,
0.07945392,
0.2847165,
0.2549554,
-0.7412851,
0.1404226,
-0.4237966,
0.2099597,
-0.02055976,
0.3615447,
0.3858805,
0.2612737,
-0.1553574,
-0... |
The order of cyanogen-bromide peptides and location of carbohydrate in the alpha2 chain of guinea-pig skin collagen. | The alpha2 chain of guinea pig skin collagen contains two additional methionyl residues in comparison with the alpha2 chain of other vertebrate species. The order of the three CNBr peptides unique to the alpha2 chain was established on the basis of the homology of their primary structures to sequences of previously ord... | 170,105 | [
-0.002271031,
-0.1145182,
-0.2443769,
0.2235413,
-0.04774271,
-0.2050336,
0.06810945,
0.1118628,
0.1057475,
0.2785921,
-0.08050242,
0.2531711,
-0.01884738,
-0.04914084,
-0.1530016,
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-0.3563729,
0.0972201,
0.08264831,
-0.1076803,
0.4851191,
0.4348996,
-0.275929,... |
Influence of agents that act on DNA and RNA synthesis on the activity of poly(ADP-Rib) polymerase. | The activity of poly(ADP-Rib) polymerase is enhanced in the presence of spermine and spermidine. Among the adenosine-like antibiotics tested, only formycin B and showdomycin cause an inhibition of the enzyme, which is competitive to NAD. The activity of poly(ADP-Rib) polymerase is not reduced by rifamycin, alpha-amanit... | 170,123 | [
-0.1241227,
0.09082197,
-0.1298148,
-0.01140691,
0.24658,
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0.07024669,
0.07053176,
0.0820035,
-0.02369704,
0.3989345,
0.3617834,
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0.1636158,
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0.1305365,
-0.2938872,
0.2204605,
0.5175815,
-0.3173635,
-0.06120786,
-... |
Membrane fractions of rabbit granulocytes. 1. The presence of ouabain-sensitive ATPase and the electrophoretic patterns. | In one or two membrane fractions isolated from the homogenate of casein-induced rabbit granulocytes ouabain-sensitive ATPase activity was found definitely. Electrophoretic patterns of these membrane fractions showed no significant differences in staining for carbohydrate and protein. | 170,125 | [
0.1229202,
0.1278338,
-0.1916668,
0.1993118,
0.1474782,
-0.3062108,
-0.07474324,
0.09714693,
0.08727752,
0.1640338,
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0.1039688,
0.1493966,
0.1556616,
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-0.3900112,
0.07323602,
-0.09128458,
0.001711201,
0.3815184,
-0.1014123,
-0.008312279,... |
Neutralizing antibody responses to varicella-zoster virus. | Neutralization of varicella-zoster (V-Z) virus by human sera and immune rhesus monkey sera was enhanced by fresh guinea pig complement. There was no marked difference in the degree to which complement enhanced neutralization by sera from current V-Z virus infections and sera from long-past varicella infections. Immunog... | 170,206 | [
-0.05854013,
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-0.06519738,
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0.07823173,
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0.3148171,
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0.01325533,
0.09496395,
0.1706078,
0.08155331,
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-0.1451011,
0.07922556,
0.1746009,
0.3098062,
0.2685235,
0.1989688,
-0.2456978... |
Immunization against Marek's disease using Marek's disease virus-specific antigens free from infectious virus. | Immunity against Marek's disease was conferred by the use of non-infectious materials extracted with non-ionic detergents from cells infected with the attenuated strain of Marek's disease virus (MDV). Antibody-free Rhode Island Red chicks were inoculated at 1 week of age with cell extracts emulsified in Freund's comple... | 170,213 | [
-0.5836435,
-0.1229677,
0.1492226,
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0.004347105,
-0.1856829,
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0.003177372,
-0.01351097,
-0.1504953,
0.1533428,
0.08213011,
0.09574658,
-0.1178295,
-0.1180731,
-0.1444058,
-0.6334209,
0.1639287,
-0.1119408,
0.1972929,
0.06193675,
-0.1572651,
-0.38845... |
Genetic control of oncogenesis by murine sarcoma virus Moloney pseudotype. II. A dominant epistatic susceptibility gene. | We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection wi... | 170,220 | [
-0.02276323,
-0.2640577,
-0.3192408,
-0.4634018,
0.1513745,
-0.283341,
0.1959556,
0.08742154,
-0.09139039,
0.05455419,
0.08662906,
0.1130675,
0.04418328,
0.4415604,
-0.6655753,
-0.3815624,
-0.07344955,
-0.01065752,
0.04748074,
0.1665767,
0.3160912,
-0.1112779,
-0.2852678,... |
[The Rothmund-Thomson-syndrome. A case report]. | This case of Rothmund-Thomson Syndrome is presented because of its association with hitherto unrecognized disorders, especially internal malignancy. The position and linkage of these associated symptomes with the genetically determined syndrome of Rothmund and Thomson is discussed. | 170,234 | [
-0.1224982,
-0.2183305,
0.109591,
-0.181735,
-0.02194966,
-0.1860623,
-0.2406805,
-0.2136186,
0.02401057,
0.1939417,
0.2341634,
0.217491,
0.131017,
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-0.2419088,
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-0.1237157,
0.07521408,
-0.05460475,
0.1219205,
0.06724761,
-0.01611228,
0... |
A new gas lesion syndrome in man, induced by "isobaric gas counterdiffusion". | Normal men have been found to develop pruritus and gas bubble lesions in the skin, and disruption of vestibular function, when breathing nitrogen or neon with oxygen while surrounded by helium at increased ambient pressure. This phenomenon, which occurs at stable ambient pressures, at 1 or many ATA, has been designated... | 170,242 | [
-0.3375955,
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0.05965843,
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0.1300471,
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0.07975458,
-0.1740052,
-0.02189855,
-0.04289987,
-0.3112233,
-0.266293,
-0.1571783,
-0.09317511,
0.04092538,
-0.04781949,
0.0004739175,
0.1810632,
-0.... |
Respiratory capacity, cyclic adenosine 3',5'-monophosphate, and morphogenesis of Mucor racemosus. | A variety of cultural conditions were examined to determine the relationship between respiratory capacity and the growth of Mucor racemosus in the yeast and mycelial form. The results show that both yeasts and hyphae can develop when the respiratory capacity is low (e.g., in N2). In addition, the yeast form of the fung... | 170,243 | [
-0.01551569,
-0.3674447,
0.01830815,
-0.2827151,
0.07383227,
-0.07562709,
-0.1637664,
0.001820435,
-0.07993575,
0.07808381,
-0.2283354,
-0.2989591,
-0.4102426,
0.1388287,
-0.3591933,
0.05042052,
-0.1002827,
0.1237958,
0.1493104,
-0.1161,
0.5800647,
-0.07346163,
-0.2092807... |
Operator-promoter functions in the threonine operon of Escherichia coli. | The prophage curing properties of secondary-site lysogens of coliphage lambda have been studied. The site of integration in the original lysogen (L79) is within the ooerator-promoter region of the thr operon. As a result, expression of the thr enzymes is reduced, and the strain is a leaky threonine auxotroph. Heat puls... | 170,244 | [
0.1452951,
-0.3452396,
-0.06617408,
-0.009333475,
-0.04332327,
-0.2969126,
0.203284,
-0.2036061,
0.4008023,
0.2118017,
0.2283809,
0.2526032,
-0.09101727,
-0.002569118,
-0.6192272,
0.05641453,
-0.8122244,
-0.5654311,
-0.1174938,
0.1964749,
0.4858935,
0.412195,
-0.244506,
... |
Active site stoichiometry of L-phenylalanine: tRNA ligase from Escherichia coli K(-10). | The existence of two active siter per molecule of L-phenylalanine:tRNA ligase from Escherichia coli K(-10) has been demonstrated by isolation of the E-aminoacyl adenylate and tel filtration and the nitrocellulose filter assay at pH 5.0 revealed the same stoichiometry for the E-tRNAPhe comples as protection against degr... | 170,267 | [
0.3185724,
0.5738193,
-0.06512752,
0.151965,
-0.1609157,
-0.2284465,
0.229845,
0.2124884,
0.05831344,
0.1374202,
-0.0141928,
0.104409,
0.05552192,
0.09164282,
-0.4661812,
-0.04140479,
-0.6472418,
0.08695624,
0.3329422,
0.3095287,
0.60605,
0.06135023,
-0.00522231,
0.1177... |
Affinity labeling of the inhibitory DPNH site of bovine liver glutamate dehydrogenase by 5'-fluorosulfonylbenzoyl adenosine. | A new adenosine analogue has been synthesized, 5'-fluorosulfonylbenzoyl adenosine, which reacts covalently with bovine liver glutamate dehydrogenase with the incorporation of approximately 1 mol of 5'-sulfonylbenzoyl adenosine per peptide chain. Native glutamate dehydrogenase is known to be inhibited by relatively high... | 170,281 | [
-0.2704998,
0.09630836,
-0.0928286,
0.1208023,
0.2886617,
0.00489695,
0.1750339,
0.3741162,
-0.08577476,
0.1096665,
-0.01160158,
0.3922202,
0.170341,
0.06312951,
-0.4391512,
0.1426841,
-0.5707462,
0.2346171,
-0.06298611,
0.3539345,
0.1957324,
0.2613766,
-0.1930357,
-0.0... |
Soft tissue response to four dense ceramic materials and two clinically used biomaterials. | Disk-shaped implants of spinel, alumina, mullite, zircon, a cast Co-Cr-Mo alloy, and ultra-high molecular weight polyethylene (UHMWPE), were implanted in the paraspinalis muscle of 12 adult, male, white New Zealand rabbits. Prior to implantation the implants were characterized with respect to size and shape, weight and... | 170,288 | [
0.208007,
0.3859487,
0.3272082,
0.03959886,
-0.4168777,
-0.1818,
-0.1237046,
0.3355243,
-0.05599544,
0.2837165,
0.06776117,
-0.2213129,
0.4378449,
-0.2484967,
-0.3574774,
-0.2467841,
-0.005223112,
0.01160503,
0.2113111,
-0.1390214,
0.2505276,
0.0932927,
-0.0418327,
0.02... |
Improved Epstein-Barr virus immunoglobulin M antibody test. | The successful demonstration of Epstein-Barr virus immunoglobulin M (EBV IgM) antibody in human sera has been accomplished to date by at least four groups of workers. Many, however, including ourselves, have had difficulty in getting reproducible results with the techniques described. The three-coat technique described... | 170,305 | [
-0.2112839,
-0.02390974,
0.07130425,
-0.1928462,
0.1124135,
-0.2892375,
-0.250527,
0.3148308,
0.2368106,
0.2560529,
0.06609682,
0.1221106,
0.3254994,
-0.08996339,
-0.6994199,
-0.1213271,
-0.1879193,
-0.0614126,
-0.1064896,
0.1959543,
0.3697731,
-0.2295867,
-0.08505787,
... |
Design and construction of an apparatus for the growth of micro cell cultures on standard glass microscope slides and its application for screening large numbers of sera by the indirect fluorescent antibody technique. | A simple stainless-steel apparatus was designed to contain standard microscope slides on which were grown micro cell cultures in the form of 16 individual monolayers per slide. The application of this apparatus for the screening of serum samples by fluorescent antibody techniques is described. | 170,316 | [
0.02875608,
-0.02658195,
0.1183844,
0.01253438,
-0.04587796,
0.07306632,
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0.5518843,
0.04526565,
0.1258757,
0.1447425,
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0.1250794,
0.1438299,
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-0.001537502,
0.06276002,
-0.1680081,
0.3037451,
0.4877917,
-0.09776838,
-0.022914... |
Measurement of parainfluenza-3 virus antibody by the single radial hemolysis technique. | A single radial hemolysis assay for parainfluenza-3 virus antibody is described as a simple, sensitive, accurate, and precise alternative to hemagglutination inhibition and serum neutralization tests. A highly significant correlation exists between single radial hemolysis zone areas and hemagglutination inhibition tite... | 170,317 | [
-0.2627271,
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0.1161882,
0.03394147,
0.190463,
0.2508782,
0.219533,
0.07833283,
0.1731045,
-0.1147042,
-0.2416741,
-0.1026615,
-0.1636347,
-0.0445528,
-0.1923739,
0.0271301,
0.316975,
-0.1708842,
0.1568265,
-0.... |
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