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Genetic mutations in genes encoding presenilins (PS1 and PS2) are responsible for the majority of early-onset familial AIzheimer's disease (FAD). Extensive studies in the past few years focusing on the mechanisms by which mutant PS promote AD pathogenesis have demonstrated that PS1 is a key component of gamma-secretase...	{ "pile_set_name": "NIH ExPorter" }
Neuronal nicotinic cholinergic receptors are expressed throughout the brain, in the spinal cord, and in the autonomic ganglia. Eleven neuronal nAChR subunit genes were cloned and sequenced in the 1980's. Some of these subunits closely resemble the a1 subunit that is included in the nAChR that is expressed at the neurom...	{ "pile_set_name": "NIH ExPorter" }
Temporal and spatial expression of laminin (LN) isoforms is critical to glomerular development and contributes to altered cell function in diabetic nephropathy and other progressive renal diseases. Yet, little is known about the mechanisms that regulate LN isoform expression. We propose that insulin-like growth factor ...	{ "pile_set_name": "NIH ExPorter" }
Chronic sinus disease affects over 31 million Americans, and surgery for this disease is performed over 200,000 times annually. Success in functional endoscopic sinus surgery (FESS) is frequently limited by poor wound healing and scar contracture. Sentrx Surgical, Inc., a University of Utah startup formed to commercial...	{ "pile_set_name": "NIH ExPorter" }
A longstanding issue in environmental health is the need to understand the role the environment plays in human brain development. The brain of the neonate is particularly susceptible to disruption of the sensory environment, which can have profound effects on its physiology and morphology. Such susceptibility of the de...	{ "pile_set_name": "NIH ExPorter" }
Establish the relationship between EEG, sleep, sympathetic tone and immune function, characterize the nocturnal secretary profile of lymphokines, neuroendocrine hormones and neurotransmitters, examine catecholamines in psychaitric patients with sleep disturbance, and test the link between sleep, neuroendocrine and symp...	{ "pile_set_name": "NIH ExPorter" }
Determining protein structure and function from genomic sequences and protein classification remains one of the most significant challenges in modern computational biology. Significant enhancement to the capacity of algorithms to predict protein shapes from sequences is proposed, focusing on major bottlenecks; e.g., th...	{ "pile_set_name": "NIH ExPorter" }
The gastrointestinal epithelium functions as a dynamic barrier that serves as an interface between luminal contents and underlying tissue compartments, and is thus vital in maintaining mucosal homeostasis. Mucosal wounds have been observed following enteric infection, inflammatory bowel disease and ischemic insults. Di...	{ "pile_set_name": "NIH ExPorter" }
Antinuclear antibodies are a central feature of SLE and related rheumatic diseases, and are thought to be directly involved in the pathogenesis of these disorders. The antigens recognized by these autoantibodies are generally components of large DNA-protein or RNA-protein particles. It has been shown that Th clones ind...	{ "pile_set_name": "NIH ExPorter" }
The objective of this project is to provide an answer to a major question concerning the sarcoplasmic reticulum, namely what is the mechanism of calcium transport through the phospholipid bilayer. The role of protein through the membrane will be investigated in which multiple subunit aggregates of the Ca ion-activated ...	{ "pile_set_name": "NIH ExPorter" }
Project Summary The major objective of the Biostatistics and Bioinformatics Core (Core 3) is to provide centralized biostatistics, bioinformatics, and database support for all Projects and Cores. Core 3 will provide guidance in the design and conduct of clinical trials and other experiments that arise from the ongoing ...	{ "pile_set_name": "NIH ExPorter" }
Natural killer (NK) cells are nonimmune cytotoxic effector cells that have the capacity to lyse certain types of NK-sensitive tumor cells. NK cells are thought to participate in immune surveillance. Therefore, elucidating the NK lytic mechanism, as well as the mechanism whereby some tumor cells resist lysis by NK cells...	{ "pile_set_name": "NIH ExPorter" }
The objective of this proposal is to provide increased understanding, at the molecular level, of the mechanisms of activation of intrinsic blood coagulation, kinin generation and fibrinolysis. Factor XII activation induced by negatively charged substances, as well as interactions among factors XII and XI, prekallikrein...	{ "pile_set_name": "NIH ExPorter" }
Kaposi's sarcoma-associated herpesvirus (KSHV) is the apparent etiological cause of Kaposi's sarcoma, a neoplasm of frequent occurrence in HIV infected individuals. The KSHV genome is present in the spindle cells of virtually all KS lesions of both HIV positive and negative cases, and there is an excellent correlation ...	{ "pile_set_name": "NIH ExPorter" }
The overall objective of this project is to identify the sequence of intracellular reactions which lead to the formation of hydrochloric acid by gastric mucosa and to identify the major controlling steps in this sequence. The project involves use of a combination of non-destructive optical techniques, conventional bioc...	{ "pile_set_name": "NIH ExPorter" }
Prior research has firmly established both that persons of lower socioeconomic status with systemic lupus erythematosus (SLE) experience poorer access to care, actual health care utilization, and outcomes due in part to the nature of their health insurance. The proposed project will assess the role that differences in ...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this contract is to assure and provide the services of a consignee and quarantine agent for New World primates imported into the United States through purchase or negotiation by the Interagency Research Animal Committee from or with the Pan American Health Organization or sovereign governments of Central...	{ "pile_set_name": "NIH ExPorter" }
The first specific aim of this project is to provide COBRE Investigators and collaborators access to state of the art high throughput genetic analysis platforms, other sophisticated equipment, and experimental capabilities. Genetic discoveries and emerging technologies are radically changing biomedical research and the...	{ "pile_set_name": "NIH ExPorter" }
A deep understanding of visual system function will require both a knowledge of the physiological properties of individual neurons and a detailed knowledge of the patterns by which these units are interconnected. Recently anatomical methods have been extraordinarily successful in determining which regions and subregion...	{ "pile_set_name": "NIH ExPorter" }
Undertreatment of pain in hospitalized patients has been associated with increased length of stay and adverse clinical outcomes such as higher complication rates, slowed would healing, and reduced quality of life. Minority populations have been shown to experience a higher likelihood of poor pain management (Cleeland, ...	{ "pile_set_name": "NIH ExPorter" }
Congenital cardiac defects affect nearly 1% of all live births and are the most common cause of infant mortality in the United States. Among the most severe forms of congenital heart defects are those involved in outflow tract and interventricular septation, whereas valve anomalies are the most common form of congenita...	{ "pile_set_name": "NIH ExPorter" }
Cyclosporine, an endecapeptide fungal product with specific anti-T-cell characteristics, will be administered to patients with sight-threatening ocular inflammatory disease of noninfectious origin who have failed on either corticosteroid or cytotoxic agent therapy. This will be done to test cyclosporine's efficacy in t...	{ "pile_set_name": "NIH ExPorter" }
Substance use during pregnancy is a major public health problem. Motivating pregnant drug-abusing women to attend outpatient treatment, however, is a significant problem. Behavioral incentives have proven highly successful in reducing illicit drug use during outpatient treatment. The proposed research will determine th...	{ "pile_set_name": "NIH ExPorter" }
ABSTRACT The objectives of the Kidney Precision Medicine Project (KPMP) project are to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies by obtaining and evaluating kidney biopsies from participants with acute kidney injury (AKI) and chronic ki...	{ "pile_set_name": "NIH ExPorter" }
Our goal is to elucidate some of the presynaptic mechanisms that control synaptic efficacy. By regulating neurotransmitter release, the activity of specific neuronal pathways can be adapted according to prior activity in the pathway and according to other neuronal and hormonal signals. These processes, we believe, are ...	{ "pile_set_name": "NIH ExPorter" }
Diabetic foot, venous stasis and pressure ulcers are examples of chronic non healing wounds that are refractory to standard therapy and represent a major health care problem especially for the increasing elderly population. Polypeptide growth factors are a class of biological mediators which have been proposed as possi...	{ "pile_set_name": "NIH ExPorter" }
Project Summary/Abstract Scandium-44 (44Sc) is a positron emitting radionuclide with a half-life of 3.97 h that is well-suited for use in positron emission tomography (PET) imaging. Scandium-47 (47Sc) is a beta emitter with a half-life of 3.345 d appropriate for targeted radiotherapy. When combined, 44Sc and 47Sc prese...	{ "pile_set_name": "NIH ExPorter" }
This request is for funds to purchase a Zeiss 510 meta confocal microscope. This instrument will be housed on the 10th floor of Salk Hall in the University of Pittsburgh School of Pharmacy. Basic and clinical research within the School of Pharmacy has grown tremendously over the past six years. During the past four yea...	{ "pile_set_name": "NIH ExPorter" }
Ionizing radiation is capable of producing several kinds of biological end results, including mutation and cell death. In spite of these possible detrimental effects on biological systems, radiation is being used both as a diagnostic tool in medicine and as a therapeutic tool in cancer treatment. The goal of this proje...	{ "pile_set_name": "NIH ExPorter" }
Calcium (Ca) is a critical regulator of cardiomyocyte contractile function. Cardiac excitation contraction (EC) coupling requires activation of the Ca release channel/ryanodine receptor (RyR2) in the sarcoplasmic reticulum (SR) by signals transmitted via the voltage-gated Ca channel/dihydropyridine receptor (DHPR) in t...	{ "pile_set_name": "NIH ExPorter" }
The complex and dynamic communities of microbes that are present on and within the human body (the human microbiota) are thought to profoundly influence human health in a variety of ways, through effects on human physiology, nutrition, immunity, and development. Studies on humans and vertebrate animal models have gener...	{ "pile_set_name": "NIH ExPorter" }
The Section is the statistical and data management component of the clinical oncology Program (COP). The Section provides statistical leadership and data management consultation for major activities of the Program, and is involved in the design, conduct, monitoring, and statistical analyses of intramural and national m...	{ "pile_set_name": "NIH ExPorter" }
The main purpose of this study is to determine the efficacy of radio- immunotherapy using a monoclonal anti-CD20 antibody labeled with 131-I in patients with B-cell lymphoma who have relapsed after chemotherapy or who have not been previously treated. Our hypothesis is that this treatment may be superior to chemotherap...	{ "pile_set_name": "NIH ExPorter" }
The urinary excretion of the renal cortical enzyme kallikrein is abnormal in various human and animal hypertensive states, including essential hypertension. These findings, as well as the relationship between the renal kallikrein-kinin system and adrenal sodium-retaining steroid activity, suggest that this system could...	{ "pile_set_name": "NIH ExPorter" }
Since interstitial cystitis is likely caused by or exacerbated by defects in the bladder's permeabllity barrier, an understanding of the bladder's barrier function may be critical to understanding the pathogenesis of this disorder. The proposed studies seek to examine, at a fundamental level, the characteristics of thi...	{ "pile_set_name": "NIH ExPorter" }
Acinetobacter baumannii is an emerging pathogen responsible for a significant percentage of nosocomial infections. It has also been problematic for the military in Iraq and Afghanistan, where it is the cause of softtissue infections associated with war-related trauma. Two properties of A. baumannii Xhaf contribute to i...	{ "pile_set_name": "NIH ExPorter" }
Abstract Embolic stroke (or cerebral embolism) accounts for approximately 25% of all strokes. It occurs when an embolus formed elsewhere in the body, lodges in a cerebral blood vessel, suddenly obstructing blood flow. Cerebral emboli most commonly arise from atherosclerotic plaques formed in the aorta, carotid artery, ...	{ "pile_set_name": "NIH ExPorter" }
Choline is necessary for the normal functioning of the mammalian organism. Hepatic steatosis associated with the use of total parenteral nutrition (TPN) is caused by choline deficiency. The aim of this study is to confirm that choline-supplemented TPN causes a decrease or resolution of hepatic steatosis in long term TP...	{ "pile_set_name": "NIH ExPorter" }
The specific aims of this proposal are to identify clinical criteria, including specific diagnostic tests, which best identify those patients who would profit from corpus callosum section; to measure the callosotomy; to develop improved criteria to select patients for each of these procedures; and to determine the imme...	{ "pile_set_name": "NIH ExPorter" }
This protocol will evaluate the utility of the two GFR markers, creatinine and cystatin C, in comparison with measured glomerular filtration rate (GFR) by iohexol clearance in 375 Black and White adult participants of the population-based Multi-ethnic Study of Atherosclerosis (MESA) cohort from the Johns Hopkins clinic...	{ "pile_set_name": "NIH ExPorter" }
The studies proposed concern the synthesis of new membrane proteins after T5-bacteriophage infection of Escherichia coli and the role of these proteins in DNA transport through the membrane, host DNA breakdown, the control of protein synthesis, and the maintenance of energy producing systems. Experiments on membrane pr...	{ "pile_set_name": "NIH ExPorter" }
Project Summary Tinnitus or ?ringing in the ears? is a hearing disorder that disproportionately impacts those who are or have served in the military. There is currently no effective cure for tinnitus. Patients with tinnitus exhibit broad changes in brain activity in the auditory system and elsewhere. One of the fundame...	{ "pile_set_name": "NIH ExPorter" }
The long-term goal of this work is to implement novel gene-based therapeutics to reverse contractile performance deficits in the failing human heart in vivo. This proposal is focused on troponin I (TnI), the inhibitory subunit of the troponin complex and molecular switch to cardiac contraction. The focus of this propos...	{ "pile_set_name": "NIH ExPorter" }
Ras oncogenes are part of a large family of related proteins. Many of these Ras-related proteins are suspected of playing a role in tumorigenic transformation. Indeed, certain Ras related proteins appear to serve as downstream components of Ras signaling and transformation. We have focussed on those proteins which not ...	{ "pile_set_name": "NIH ExPorter" }
[unreadable] [unreadable] The specific aim of the Phase II project is to complete the design and develop a full interactive virtual experience that will reduce the risk faced by First Responders when dealing with incidents involving hazardous materials. If First Responders, particularly fire fighters, follow a systemat...	{ "pile_set_name": "NIH ExPorter" }
This proposal is for an Underrepresented Minority Supplement for Wilmarie Morales- Soto, a second year predoctoral student in the Neuroscience Graduate Program, to the funded parent RO1 (RO1DK103723). Wilmarie?s research project will build upon studies described in specific aim 1 of the parent grant. Aim 1 is designed ...	{ "pile_set_name": "NIH ExPorter" }
The proposed investigation will include the identification of the metabolic pathways of oxalate metabolism in man and other mammals and the isolation, purfication and characterization of the enzymes involved. The contribution of each pathway and oxalate precursor will be evaluated in the light of potential regulation a...	{ "pile_set_name": "NIH ExPorter" }
The proposed study is designed to improve assessment techniques currently available in the substance abuse field by establishing the psychometric properties of screeners for trauma history and for trauma-related psychological symptomatology, specifically post-traumatic stress disorder (PTSD). It will assess the utility...	{ "pile_set_name": "NIH ExPorter" }
This is a continuation to develop and expand upon data collected in a retrospective longitudinal study exploring the relationships among a variety of sexual experiences - including sexual socialization, voluntary sexual practices, and sexual abuse - and their effect on women's psychological well-being. Previous researc...	{ "pile_set_name": "NIH ExPorter" }
Linguistic and psychological theory coupled with empirical studies on the heritability of individual differences in language development and language disorders support the hypothesis that the capacity for language development in humans is genetically influenced. The proposed research will provide for further understand...	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION (provided by investigator): The early years between ages 3 -7 have been described as a critical period in the development of obesity. The importance of the family on the development of eating and physical activity behaviors in young children has been emphasized by experts, yet to date no obesity prevention ...	{ "pile_set_name": "NIH ExPorter" }
Completion of sequencing of the human and of bacterial genomes has made it possible to apply the principle of oligonucleotide hybridization competition to the inhibition of nefarious genic expression. We shall focus our efforts on three targets: l) M. tuberculosis, with its uniquely constructed mycocerosic outer cell w...	{ "pile_set_name": "NIH ExPorter" }
The structure of tandem chromosomal duplications of the tryptophan operon will be studied in S. typhimurium. Factors which affect the stability of the duplications will be studied including the effects of interactions of mutant supX, recA, recB and recC alleles with temperature, UV and photo reactivating light. Studies...	{ "pile_set_name": "NIH ExPorter" }
My career goal is to become an academic psychiatrist and independent investigator in the areas of schizophrenia focusing on its neurobiology and therapeutics, applying molecular mechanism-based research to prospective clinical studies. Specifically, I propose to investigate the importance of neurosteroids in schizophre...	{ "pile_set_name": "NIH ExPorter" }
Osteoarthritis (OA), which affects millions of Americans, is a debilitating condition characterized by the loss of articular cartilage at the join surfaces. Osteoarthritis is a promising candidate for regenerative stem cell therapy. However, despite decades of investigation, the cells and molecular pathways that repair...	{ "pile_set_name": "NIH ExPorter" }
Dental caries is one of the most prevalent chronic infections in humans. It is caused by acid production from fermentation conducted by acidogenic bacteria that colonize the tooth surface. Intake of fermentable carbon by the host promotes acid generation, resulting in tooth demineralization, which is symptomatic of den...	{ "pile_set_name": "NIH ExPorter" }
We employ several approaches to attempting to understand the etiology and pathogenesis of multiple sclerosis. We will continue attempts to recover a virus or identify virus antigen in brain tissue of patients with MS. We will use human tissues in culture and animal model systems in vivo and in vitro to study the behavi...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this agreement is to provide support to the Center for Substance Abuse Treatment[unreadable]s (CSAT) initiative with the Washington Circle to advance the science of performance and quality measurement of addiction services.	{ "pile_set_name": "NIH ExPorter" }
Work will continue on an investigation by small-angle x-ray scattering of the structure of E. coli ribosomes in solution. Radius of gyration measurements will be made on the 50S ribosome in H2O and D2O. The measurements will be made on samples prepared by Engleman and Moore of Yale University for comparison with their ...	{ "pile_set_name": "NIH ExPorter" }
The key features of the Molecular Biology Core of the Skin Disease Research Center are its[unreadable] comprehensive range of services designed to support the needs of both proposed and future SDRC[unreadable] members, and its objective of training young investigators in the area of its expertise. This Core[unreadable]...	{ "pile_set_name": "NIH ExPorter" }
The objectives of this project are to understand and modulate the processes of kindling and quenching. Kindling involves the development of convulsions following repeated, intermittent administration of a subconvulsant stimulation. Quenching is a procedure developed in our laboratory to inhibit the development and expr...	{ "pile_set_name": "NIH ExPorter" }
The goal of the proposed research is to understand the process of intracellular proteolysis in bacteria. Already available peptidase mutants of Salmonella typhimurium and E. coli will be further characterized and new types will be obtained. The important peptidases and proteases will be purified and characterized bioch...	{ "pile_set_name": "NIH ExPorter" }
It is widely accepted that the hepatotoxicity of CCl4 results from the metabolism of CCl4 to the trichloromethyl free radical by cytochrome P- 450. Earlier studies reported that sublethally CCl4-treated rabbits were 1`0 times more susceptible than normal rabbits to the lethal effect of bacterial endotoxin. Endotoxin ab...	{ "pile_set_name": "NIH ExPorter" }
Multiple Sclerosis (MS) is a common neurological disorder characterized by immune attack on myelin and mylein forming cells of the central nervous system. Current treatments are directed at reducing the immune-mediated inflammatory damage to myelin. Recent observations from neuroimaging and pathological research demons...	{ "pile_set_name": "NIH ExPorter" }
Botulinum neurotoxins (BoNTs) represent one of the most serious bioterror threats to our national security. Secreted by spore forming bacteria Clostridium botulinum, baratii, and butyricium, BoNTs are responsible for the flaccid paralysis associated with botulism. Listed as category A biothreats by the CDC, BoNTs are t...	{ "pile_set_name": "NIH ExPorter" }
Human leishmaniasis is caused by the Leishmania spp. In this protozoan parasite, initiation of transcription is not a major mode of gene regulation. Consequently, post-transcriptional pathways for controlling protein expression, which is critical for virulence, are of utmost importance. Untranslated regions of mature m...	{ "pile_set_name": "NIH ExPorter" }
SUMMARY The spatial and temporal organization of intracellular components by the microtubule cytoskeleton is required for cell division, many aspects of development, and neuronal function. Defects in the microtubule cytoskeleton cause neurological diseases in humans. The long-term goal of this research program is to de...	{ "pile_set_name": "NIH ExPorter" }
The effects of ryanodine on left ventricular (LV) function and hemodynamics were studied in 16 conscious dogs, chronically instrumented for measurements of LV pressures and dimensions. Systemic infusion of ryanodine (0.5 - 4 fg/kg i.v.) resulted in a dose-dependent depression of cardiac contraction. For example, ryanod...	{ "pile_set_name": "NIH ExPorter" }
The effects of hypoxia on contraction and relaxation in chick embryo ventricular cells cultured as confluent, spontaneously contracting monolayers will be studied. Inotropic effects are detected by measurement of changes in the amplitude and velocity of individual cell wall motion. Similar changes in cell wall motion d...	{ "pile_set_name": "NIH ExPorter" }
Extreme changes in cellular architecture are experienced by germ cells during spermatogenesis. The most extensive of these changes take place after meiosis, when the chromatin is condensed, the nuclei are dramatically reshaped, the mitochondria fuse into a single giant organelle, and extensive reorganization of the cyt...	{ "pile_set_name": "NIH ExPorter" }
To improve the effectiveness of medical treatment for people with lung disease produced by cigarette smoking. Chronic obstructive pulmonary disease (COPD) is a disabling disorder and inability to exercise is a foremost problem. Focus will be on strategies predicted to improve the muscle's ability to tolerate exercise. ...	{ "pile_set_name": "NIH ExPorter" }
In adult dogs after pneumonectomy (PNX), mechanical forces on the remaining lung are thought to stimulate compensatory lung growth. Following moderate (42% of total) resection, lobar growth is non-uniform. As resection increases (58-70%), alveolar growth is stimulated in all remaining lobes probably due to mechanical f...	{ "pile_set_name": "NIH ExPorter" }
During the early development of D. melanogaster a single egg cell is converted into a multicellular organism (the first instar larva) which contains in a defined spatial arrangement a variety of specialize organs, tissues, and cell types. The steps in embryogenesis of D. melanogaster include: differential cell division...	{ "pile_set_name": "NIH ExPorter" }
The proposed study, the Mexican Health and Aging Study-II (MHAS-II), aims to design and field the 3rd and 4th waves of survey data collection in Mexico. The two waves will be fielded in 2012 and 2014, eleven years after the two previous waves funded by NIA/NIH were fielded in 2001 and 2003. Funds are sought also to arc...	{ "pile_set_name": "NIH ExPorter" }
To study the effect of Type C RNA viruses on hematopoiesis with particular emphasis being placed on the spontaneous disease in AKR mice. Major emphasis will be placed on the preleukemic phase of the disease, i.e., hematopoietic changes occurring during the first 3 months of life. To contrast animal data in Rauscher vir...	{ "pile_set_name": "NIH ExPorter" }
I propose to investigate the role of calcium and cyclic nucleotides in the physiology of the vertebrate rod photoreceptor. It is well established that these substances are involved in generating the rod's electrical response to light. However, the difficulty of observing the light regulation of calcium and cyclic GMP i...	{ "pile_set_name": "NIH ExPorter" }
This is an open label, Phase II, multicenter study. Patients will receive Atragen 140mg/m2-three times weekly. The drug will be given on Monday, Wednesday and Friday over a course of 28 days. Patients will continue to receive therapy for a minimum of six months, unless evidence of disease progression. The primary objec...	{ "pile_set_name": "NIH ExPorter" }
An isolated anterior echo-free space is generally regarded as a false-positive echocardiographic finding for pericardial effusion. Even when an anterior echo-free space is accompanied by a posterior echo-free space, the echo-free spaces have been occasionally reported to be falsely positive for pericardial effusion, pr...	{ "pile_set_name": "NIH ExPorter" }
The primary aim of this study is to further examine the effects of hypokalemia and hypernatremia on the blood perfused working heart of the dog. In some animals the changes will be produced locally by interposing a blood dialyzer in the left common coronary artery. Experiments already completed indicate that local hypo...	{ "pile_set_name": "NIH ExPorter" }
Building on our success as world leaders in acute lymphoblastic leukemia (ALL) and as leaders in the Pharmacogenomics Research Network (PGRN), we have formed a Center for Precision Medicine in Leukemia. Our goal is to identify the mechanisms underlying interpatient variability in response to antileukemia medications. W...	{ "pile_set_name": "NIH ExPorter" }
Sensory inputs are not represented faithfully in the brain. Rather, they are integrated with the information provided by the animal's internal states that are affected by factors including arousal, attention, prediction and experience. This integration process is impaired in psychiatric disorders such as schizophrenia ...	{ "pile_set_name": "NIH ExPorter" }
The major focus of this project is the development of a vaccine to prevent or control infections caused by Chlamydia trachomatis. The chlamydial major outer membrane protein (MOMP) is considered to be important in the development of protective immunity to chlamydial infection. Thus, current vaccine strategies are focus...	{ "pile_set_name": "NIH ExPorter" }
PROJECT SUMMARY: Clinical research must enroll individuals from diverse backgrounds to yield generalizable knowledge and ensure that the benefits and burdens of research are fairly distributed. Under- representation of diverse groups may: (1) lead to poor enrollment leading to delays and/or study failure, (2) prevent d...	{ "pile_set_name": "NIH ExPorter" }
PROJECT 1: RSV bronchiolitis and early childhood asthma are the most common, serious, acute, and chronic conditions of infancy and childhood, respectively, and diseases that disproportionately burden vulnerable populations. Opportunity and Impact. This project draws together three important elements in understanding th...	{ "pile_set_name": "NIH ExPorter" }
The NICHD's Contraceptive Clinical Trials network conducts Phase I, II and III clinical trials of a wide variety of new female and male contraceptive methods. The objective of this contract is for CCTN contractors to conduct female contraceptive clinical trials, conduct treatment trials of gynecologic conditions, and t...	{ "pile_set_name": "NIH ExPorter" }
Abdominal Aortic Aneurysm (AAA) is a common and devastating disease which is increasing in incidence. Although easy and inexpensive to detect by ultrasound, most aneurysms are small when detected and there is currently no medical regimen which will inhibit their growth. There is an increasing body of evidence implicati...	{ "pile_set_name": "NIH ExPorter" }
We propose to assess the robustness of a high-throughput mass spectrometric (MS) technology platform for quantitative measurement of multiple candidate biomarker proteins in complex samples such as human plasma. Specific assays will be developed for 300 candidate biomarker proteins drawn from published literature, path...	{ "pile_set_name": "NIH ExPorter" }
This project will test the underlying hypothesis that hospital behavior and performance are influenced by the spatial configuration of the local hospital market. Hospital performance has typically been examined with cross-sectional approaches that assume each hospital is independent. Physicians and hospital administrat...	{ "pile_set_name": "NIH ExPorter" }
Intravenous drug abuse continues to be a major contributor in the perpetuation of the AIDS epidemic. Primarily, this situation relates to the needle-sharing and sexual practices of addicts. However, there is also ample evidence to suggest that the drugs themselves are an integral part of the problem through their immun...	{ "pile_set_name": "NIH ExPorter" }
Substance use disorders (SUDs) are chronic, recurring disorders of major cost to society at all stages of the life cycle. They are of particula concern in Ukraine, whose rate of alcohol use is 5th highest in the world and whose lifetime rate of illicit drug use is already 21% by age 16 (WHO, 2011). At the same time, be...	{ "pile_set_name": "NIH ExPorter" }
Project Summary (Abstract) Obstructive sleep apnea (OSA) is a common sleep disorder affecting a significant portion of adult population in United States. OSA results in poor quality of sleep and is associated with increased cardiovascular risk, including hypertension. Blood pressure (BP) is known to increase with each ...	{ "pile_set_name": "NIH ExPorter" }
Studies in this laboratory focus upon an analysis of the neural control of cardiac dynamics and rhythm in behaviorally conditioned, unanesthetized animals. Previous studies have indicated that post-myocardial infarction cardiac arrhythmias occur principally within a specified range of heart rates (the "critical HR rang...	{ "pile_set_name": "NIH ExPorter" }
The objective of this project is to provide information on metabolic changes occurring in nuclei of pancreatic tissue exposed to carcinogens. The initial studies indicated that exposure to 7,12-dimethylbenzanthracene (DMBA) resulted in alterations in content of DNA and RNA for periods up to 35 hours after exposure. Pro...	{ "pile_set_name": "NIH ExPorter" }
Instrumentation is in place to capture images for morphometry of neurons developing in the absence of electrical activity. Redesign of multicompartment chambers for the study of activity effects on synapse stabilization / elimination improves optical resolution and axonal growth. Antibodies against the vesicular acetyl...	{ "pile_set_name": "NIH ExPorter" }
Data from the initial funding period of this grant have substantially informed us regarding the interaction between CVD and AD pathologies as they relate to the transitions between normal aging, MCI and dementia. These data suggest that CVD affects cognition through impairment of executive function, which in turn, adve...	{ "pile_set_name": "NIH ExPorter" }
This is the first renewal of a Program Project that has been in effect for two years. It was originally submitted in order to study the molecular related to a number of devastating human conditions which have as their central feature an association with the with the major histocompatibility complex. Three investigators...	{ "pile_set_name": "NIH ExPorter" }
Transcripts of the cellular c-Ha-ras are increased during liver regeneration and at certain stages in diet-induced hepatocarcinogenesis in rats. C-Ha-ras is the cellular homologue of the transforming gene of Harvey murine sarcoma virus. In liver regeneration, induced by either partial hepatectomy or carbon tetrachlorid...	{ "pile_set_name": "NIH ExPorter" }
LIUNA Training and Education Fund (LIUNA Training) is applying for the Hazardous Materials Worker Health and Safety Training cooperative agreement, RFA-ES-09-004 to conduct a Hazardous Waste Worker Training Program (HWWTP - $18,154,084) and a Hazmat Disaster Preparedness Training Program (HDPTP - $1,902,370), at a tota...	{ "pile_set_name": "NIH ExPorter" }
The purpose of this study is to interrelate biochemical activity and cytoanatomic structure of the leukemic lymphocyte to its in vitro and in vivo response to antineoplastic agents.	{ "pile_set_name": "NIH ExPorter" }
DESCRIPTION: (adapted from the application): This application proposes a three year continuation of Dr. David Wise s academic leadership award on the economics of aging. The initial award was made in April, 1994 and approved through March, 1997. The purpose of the initial award was to extend the National Bureau of Econ...	{ "pile_set_name": "NIH ExPorter" }

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