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### Instruction:
Does lipid to protein ratio play an important role in the skin barrier function in patients with atopic eczema?
### Response:
| The lipid/protein ratio plays a role in the reduced skin barrier function in AE. |
### Instruction:
Do serum albumin levels predict clinical outcomes in chronic kidney disease ( CKD ) patients undergoing cardiac resynchronization therapy?
### Response:
| Hypoalbuminemia independently predicts cardiac morbidity and mortality in CKD patients receiving CRT. Assessing the albumin levels provides valuable information regarding the long-term prognosis in CKD patients who undergo CRT. |
### Instruction:
Are elevated preoperative serum cancer antigen 15.3 levels associated with reduced disease-free survival : a single-institution experience?
### Response:
| Elevated preoperative CA 15.3 above 35 U/mL in Saudi women breast cancer patients showed correlation with primary tumor size and nodal status, and preoperative CA 15.3 level is an independent prognostic factor for DFS. Preoperative serum CA 15.3 levels may be helpful for risk stratification along with other factors. |
### Instruction:
Is interplay of proliferation and proapoptotic and antiapoptotic factors revealed in the early human inner ear development?
### Response:
| The described expression pattern indicates roles for cell proliferation in the growth of the inner ear and Bcl-2 in differentiation of sensorineural fields and protection from apoptosis. Both IGF-1-and caspase-3-mediated apoptosis seem to contribute to proper morphogenesis, differentiation, and innervations of sensorin... |
### Instruction:
Does activation of the δ-opioid receptor promote cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration?
### Response:
| Opioid receptors affect intercellular adhesion and wound healing mechanisms, underlining the importance of a cutaneous neuroendocrine system in wound healing and skin homeostasis. |
### Instruction:
Does post-treatment with Telfairia occidentalis seed oil attenuate alcohol-induced testicular damage in Sprague-Dawley rats?
### Response:
| Our result suggests that T.O promotes the regeneration of testicular germ cells and improves semen quality at a certain critical dose. Hence, T.O has a potential of reversing ethanol induced testicular damage. |
### Instruction:
Is low free testosterone associated with loss of appendicular muscle mass in Japanese community-dwelling women?
### Response:
| A low-free testosterone level appears to be a significant predictor of the risk for loss of appendicular muscle in Japanese women. |
### Instruction:
Does helicobacter pylori modulate cisplatin sensitivity in gastric cancer by down-regulating miR-141 expression?
### Response:
| Altogether, these findings demonstrated that the H. pylori infection could modulate cisplatin sensitivity through miR-141-mediated regulation of KEAP1. |
### Instruction:
Is the evolving use of higher risk grafts associated with an increased incidence of acute kidney injury after liver transplantation?
### Response:
| The increasing use of higher risk liver grafts is associated with an increased incidence of AKI. These findings support the need for therapies that minimise the hepatic ischaemia-reperfusion injury. |
### Instruction:
Are low doses of haloperidol combined with ondansetron effective for prophylaxis of postoperative nausea and vomiting in susceptible patients?
### Response:
| In high risk patients for PONV who underwent highly emetogenic surgeries, the efficacy of low-dose haloperidol (1mg) in combination is limited. Higher doses (2mg) are more effective but its use is associated with a high incidence of side effects. |
### Instruction:
Does music induce different cardiac autonomic arousal effects in young and older persons?
### Response:
| During silence, autonomic modulation was lower - but showed sympathetic predominance - in older than younger persons. Responses to music-onset, particularly "aggressive" music, reflect more of an arousal- than an emotional-response to music valence, with age-specific shifts of sympathetic-parasympathetic balance mediat... |
### Instruction:
Does probiotic administration attenuate myocardial hypertrophy and heart failure after myocardial infarction in the rat?
### Response:
| The study suggests that probiotics offer promise as a potential therapy for the attenuation of heart failure. |
### Instruction:
Does effects of Fumaria parviflora leave extract on reproductive parameters in adult male rats?
### Response:
| The results indicated that ethanolic extract of F. parviflora leaves have a potential to improve reproductive parameters and enhance male fertility. |
### Instruction:
Do low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A ( H1N1 ) 2009 infection?
### Response:
| Early negative A(H1N1) 2009 HI serology can predict death from influenza. This negative serology in fatal cases in young adults reflects the trapping of anti-H1N1 antibodies in immune complexes in the lungs, associated with poor specific helper T-cell response. Clinical trial registered with www.clinicaltrials.gov (NCT... |
### Instruction:
Is hY immune tolerance common in women without male offspring?
### Response:
| HY-specific Treg in women with male offspring have been described previously. Here we show for the first time that, in fact, HY specific Treg are more common in nulliparous women and in parous women with female offspring. Their presence is independent of the presence of male microchimerism. Whether HY-specific Treg pre... |
### Instruction:
Does cabozantinib reverse multidrug resistance of human hepatoma HepG2/adr cells by modulating the function of P-glycoprotein?
### Response:
| Cabozantinib reverses P-gp-mediated MDR by directly inhibiting the efflux function of P-gp, indicating that cabozantinib may help to reverse P-gp-mediated MDR in HCC and other cancer chemotherapy. |
### Instruction:
Is tNFAIP8 overexpression associated with lymph node metastasis and poor prognosis in intestinal-type gastric adenocarcinoma?
### Response:
| Our data suggest that TNFAIP8 overexpression may contribute to lymph node metastasis and poor prognosis in IGA. |
### Instruction:
Are impaired resting myocardial annular velocities independently associated with mental stress-induced ischemia in coronary heart disease?
### Response:
| MSIMI but not exercise stress-induced myocardial ischemia is independently associated with resting abnormalities in myocardial systolic and late diastolic velocities as well as the integrated measure of the eas index in patients with known coronary artery disease. (Responses of Myocardial Ischemia to Escitalopram Treat... |
### Instruction:
Is her2 expression and gene amplification rarely detectable in patients with oral squamous cell carcinomas?
### Response:
| Our results demonstrate that Her2 protein and gene amplification was only detectable in a small subset of squamous cell carcinomas of the head and neck region as well as oral squamous cell carcinomas. However, it can be speculated that those few patients with Her2 overexpressing and gene amplificated tumors may possibl... |
### Instruction:
Do elevated plasma S100B levels in high altitude hypobaric hypoxia correlate with acute mountain sickness?
### Response:
| Ascending to 3700 m resulted in elevated plasma S100B levels but this was not associated with AMS. |
### Instruction:
Does relocation of genes generate non-conserved chromosomal segments in Fusarium graminearum that show distinct and co-regulated gene expression patterns?
### Response:
| Our results showed that chromosomes can be functionally divided into conserved and non-conserved regions, and both could have specific and distinct roles in genome evolution and regulation of gene expression. |
### Instruction:
Is clinical review essential to evaluate 30-day mortality after trauma?
### Response:
| Clinical review of all trauma deaths was essential to interpret mortality. Thirty-day trauma mortality included 10.5% deaths not directly related to the injury and the exclusion of patients dead on arrival significantly affected the unadjusted mortality rate, ISS, median age and time to death. |
### Instruction:
Does chromium picolinate inhibit cholesterol-induced stimulation of platelet aggregation in hypercholesterolemic rats?
### Response:
| Chromium supplementation to hypercholesterolemic rats improves the lipid profile and returns platelet hyperaggregability to control levels. This normalization is mostly due to a reduction in plasma cholesterol level. |
### Instruction:
Does oral sophocarpine protect rat heart against pressure overload-induced cardiac fibrosis?
### Response:
| These findings indicated that sophocarpine potentially had antifibrotic effects. The mechanism might be due to modulation of the balance between pro-inflammatory cytokine expression and collagen content level as well as MMPs expression via the NF-κB signaling pathway. |
### Instruction:
Does hydroxysafflor yellow A suppress liver fibrosis induced by carbon tetrachloride with high-fat diet by regulating PPAR-γ/p38 MAPK signaling?
### Response:
| These data demonstrate a novel role for HSYA in inhibiting CCl4- and HFD-mediated liver fibrosis, and reveal that PPAR-γ and p38 MAPK signaling play pivotal roles in the prevention of liver fibrosis induced by CCl4 and HFD. |
### Instruction:
Do diabetes autoantibodies predict progression to diabetes in adults : the Diabetes Prevention Program?
### Response:
| These data suggest that 'diabetes autoimmunity', as reflected by GAD antibodies and insulinoma-associated-2 autoantibodies, in middle-aged individuals at risk for diabetes is not a clinically relevant risk factor for progression to diabetes. |
### Instruction:
Does tauroursodeoxycholic acid reduce glial cell activation in an animal model of acute neuroinflammation?
### Response:
| We show a triple anti-inflammatory effect of TUDCA on glial cells: i) reduced glial cell activation, ii) reduced microglial cell migratory capacity, and iii) reduced expression of chemoattractants (e.g., MCP-1) and vascular adhesion proteins (e.g., VCAM-1) required for microglial migration and blood monocyte invasion t... |
### Instruction:
Does pre-transplant renal impairment predict posttransplant cardiac events in patients with liver cirrhosis?
### Response:
| Pretransplant renal impairment is a predictor of cardiac event after liver transplantation together with prolonged QTc interval. |
### Instruction:
Does genetic variation in caveolin-1 affect survival after lung transplantation?
### Response:
| We conclude that the GG genotype of CAV-1 is protective, associated with a decreased overall mortality but not with acute or chronic rejection, LB, and respiratory infections after LTx. The decreased mortality was linked with less infections of any kind and also lower systemic CRP, and airway neutrophils were observed,... |
### Instruction:
Are fruit and vegetable intake and related nutrients associated with oxidative stress markers in middle-aged men?
### Response:
| Greater FV intake was independently associated with reduced ox-LDL, 8-OHdG, and 8-iso-PGF2 α in middle-aged men. Fiber, vitamin C, and magnesium from FV seem to contribute to this beneficial relationship. |
### Instruction:
Do high protein diets attenuate decrements in testosterone and IGF-I during energy deficit?
### Response:
| Consuming a high protein diet does not impact the androgenic and IGF-I system response to ED. These data suggest that the protective effects of high protein diets on FFM during ED are likely not influenced by anabolic hormone concentrations. |
### Instruction:
Are preferences for salty and sweet tastes elevated and related to each other during childhood?
### Response:
| For children, sweet and salty taste preferences were positively correlated and related to some aspects of real-world food intake. Complying with recommendations to reduce added sugars and salt may be more difficult for some children, which emphasizes the need for new strategies to improve children's diets. |
### Instruction:
Does intrathecal fentanyl decrease the optimal effect site concentration of propofol during spinal anaesthesia?
### Response:
| The EC50 of the effect-site concentration of propofol for sedation decreased from 1.67 ± 0.28 mcg/ml to 0.87 ± 0.15 mcg/ml with the addition of 25 mcg fentanyl to a spinal anaesthetic in patients undergoing urologic surgery. |
### Instruction:
Is strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes limited to subjects with satisfactory glycaemic control?
### Response:
| Postprandial glucose excursions may explain glycaemic variability and total glucose exposures in well-controlled T2DM patients. |
### Instruction:
Is acute renal failure associated with higher death and disability in patients with acute ischemic stroke : analysis of nationwide inpatient sample?
### Response:
| ARF in patients with AIS is associated with significantly higher rates of moderate to severe disability at discharge and in-hospital mortality. |
### Instruction:
Does fluid-attenuated inversion recovery hyperintensity correlate with matrix metalloproteinase-9 level and hemorrhagic transformation in acute ischemic stroke?
### Response:
| FR correlates with both MMP-9 level and risk of hemorrhage. FLAIR changes in the acute phase of stroke may predict hemorrhagic transformation, possibly as a reflection of altered blood-brain barrier integrity. |
### Instruction:
Is prothrombin G20210A mutation associated with young-onset stroke : the genetics of early-onset stroke study and meta-analysis?
### Response:
| The prothrombin G20210A mutation is associated with ischemic stroke in young adults and may have an even stronger association among those with earlier onset strokes. Our finding of a stronger association in the younger young adult population requires replication. |
### Instruction:
Is geranylgeranylacetone and volatile anesthetic-induced cardiac protection synergism dependent on caveolae and caveolin-3?
### Response:
| Combined administration of GGA + isoflurane had a synergistic effect, enhancing the protection against myocardial infarction to a greater extent than either drug alone. This beneficial effect is mediated by Cav-3 expression. |
### Instruction:
Does diffusion-weighted magnetic resonance imaging detect significant prostate cancer with high probability?
### Response:
| Diffusion-weighted magnetic resonance imaging (3 Tesla) is a noninvasive technique that allows for the detection of significant prostate cancer with high probability without contrast medium or an endorectal coil, and with good interreader agreement and a short reading time. This technique should be further evaluated as... |
### Instruction:
Does acute administration of THC impair spatial but not associative memory function in zebrafish?
### Response:
| The results are very coincident with reports on mammals, demonstrating that the ECS is functional highly conserved during vertebrate evolution. We further conclude that the zebrafish provides a promising model organism for ongoing research on the ECS. |
### Instruction:
Do bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms?
### Response:
| These data suggest that increased circulating serum bile acids may contribute to the increased permeability of the blood brain barrier seen during obstructive cholestasis via disruption of tight junctions. |
### Instruction:
Is extracellular signal-regulated kinase 1/2 involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model?
### Response:
| Our results suggest that intravenous injection of TMX may ameliorate TBI in rats by increasing neuronal p-ERK1/2 expression, which might lead to an increase in neuronal Bcl2 expression and a decrease in neuronal apoptosis and cell infarction volume, and it might represent one mechanism by which functional recovery occu... |
### Instruction:
Does endothelial cell-specific liver kinase B1 deletion cause endothelial dysfunction and hypertension in mice in vivo?
### Response:
| Our findings indicate that endothelial LKB1 regulates endothelial nitric oxide synthase activity, endothelial function, and blood pressure by modulating AMP kinase-mediated caveolin-1 expression. |
### Instruction:
Do h-reflexes reduce fatigue of evoked contractions after spinal cord injury?
### Response:
| nNMES generates contractions that fatigue less than mNMES, but only when H-reflexes contribute to the evoked contractions. |
### Instruction:
Is atypical distribution of inflammation in newly diagnosed ulcerative colitis rare?
### Response:
| Patchy⁄segmental skip lesions and rectal sparing occur not infrequently in adult patients with newly diagnosed, untreated UC. As such, these features alone should not be considered to be definitive evidence against a diagnosis of UC. There does not appear to be a prognostic implication of an atypical distribution of le... |
### Instruction:
Does virological response to short-course maraviroc monotherapy predict viral tropism in HIV-1-infected treatment-naive patients?
### Response:
| Treatment-naive patients infected with R5- or D/M-tropic virus have similar virological responses to a short course of maraviroc monotherapy. This clinical test thus cannot be used as a surrogate marker of viral tropism in this population. |
### Instruction:
Is conventional endovascular treatment of small intracranial aneurysms associated with additional risks compared with treatment of larger aneurysms?
### Response:
| Treatment of small intracranial aneurysms via conventional endovascular coiling techniques is not inferior to endovascular treatment of larger aneurysms based on our single institution experience. While technically challenging, such aneurysms may be treated safely and effectively with acceptable rates of complications ... |
### Instruction:
Is city population size associated with examinee outcomes on the American Board of Pediatrics Certifying Examination?
### Response:
| City size is associated with examinee performance on the American Board of Pediatrics Certifying Examination. City size should be a consideration of future residency applicants. |
### Instruction:
Does curcumin modulate TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats?
### Response:
| Post-SCI curcumin administration attenuates the TLR4/NF-κB inflammatory signaling pathway in the injured spinal cord, and this may be a mechanism whereby curcumin improves the outcome following SCI. |
### Instruction:
Is clustering of comorbidities related to age and sex and impacts clinical outcome in myelodysplastic syndromes?
### Response:
| Comorbidities impact clinical outcome in elderly patients with MDS. Distinct diseases cluster in an age- and sex-related manner, which may have clinical implications when designing individualized therapies. Comorbidities should be evaluated with established scores and integrated in decision making. |
### Instruction:
Does effects of the Aqueous Extract of Anethum graveolens leave on Seizure Induced by Pentylenetetrazole in Mice?
### Response:
| The obtained data shows that the aqueous extract possesses anticonvulsant activity against seizure induced by PTZ. The presence of anticonvulsant compounds in this medicinal herb suggests further activity and guided fractionation studies in order to introduce this plant as a valuable source of anticonvulsant agents. |
### Instruction:
Do median frequencies of prolonged ventricular fibrillation treated by V-A ECMO correspond to a return of spontaneous circulation rate?
### Response:
| The veno-arterial ECMO reperfusion influences MF of VF wavelet obtained from right ventricular apex. The course of changes in wavelet frequency corresponds to a presence of later ROSC. |
### Instruction:
Does peritoneal dialysis adversely affect kidney function recovery after congenital heart surgery?
### Response:
| Our results suggest renal replacement therapy does not change the time course of kidney function recovery. |
### Instruction:
Does phosphoprotein analysis reveal MEK inhibition as a way to target non-small cell lung cancer tumor initiating cells?
### Response:
| We demonstrate reduced basal phosphorylation of several signaling pathways including lower total IGF-1R levels in NSCLC TIC which is of potential concern for RTK inhibitor use. Importantly, MEK inhibition decreased cell viability of NSCLC TIC alone or in combination with IR. |
### Instruction:
Does lansoprazole enhance the antidiabetic effect of sitagliptin in mice with diet-induced obesity and healthy human subjects?
### Response:
| LPZ and SITA combination therapy appears to have complementary mechanisms of action and additive antidiabetic effect. |
### Instruction:
Are genetic polymorphisms in glutathione-S-transferases associated with anxiety and mood disorders in nicotine dependence?
### Response:
| This study suggests that at least one deletion of the GSTM1 and GSTT1 genes represents a risk factor for anxious smokers. These two genes may modify the capacity for the detoxification potential against oxidative stress. |
### Instruction:
Does thymic size correlate with cord blood zinc levels in low-birth-weight newborns?
### Response:
| Thymic index is linearly related to cord blood zinc levels and maternal and neonatal nutritional status. Compared to thymic size in the Western newborns, the thymus is less than half in size in Indian newborns of normal birth weight. Reduced thymic size in Indian newborns in general and LBW infants in particular may ha... |
### Instruction:
Is individual migration timing of common nightingales tuned with vegetation and prey phenology at breeding sites?
### Response:
| Our findings suggest that male nightingale used cues other than local phenology for their departure decisions from non-breeding grounds and that there is some evidence for equalizing late departures during the course of migration. |
### Instruction:
Is therapeutic site selection important for the successful development of collateral vessels?
### Response:
| These findings demonstrated that selective bFGF delivery to the coccygeofemoral muscle markedly improved collateral development and limb perfusion compared with delivery to the adductor muscle, suggesting that site selection is important in increasing therapeutic efficacy. |
### Instruction:
Is feedback on baseline use of staging images important to improve image overuse with newly diagnosed prostate cancer patients?
### Response:
| The incidences of positive staging image in low- and intermediate- risk group were reasonably low. Following feedback on these results, staging in low- and intermediate- risk groups could be omitted. |
### Instruction:
Do [ Study on the hepatoxicity of polygoni multiflori radix and polygoni multiflori rodix praeparata in rats ]?
### Response:
| Oral administration of Polygoni Multiflori Radix and Polygoni Multiflori Rodix Praeparata for 60 days have hepatoxic in rats. |
### Instruction:
Does fSH suppression affect bone turnover in eugonadal men?
### Response:
| When gonadal steroid levels are held constant, short-to midterm suppression of FSH does not affect bone turnover in men. FSH does not appear to be a significant regulator of bone metabolism in eugonadal men. |
### Instruction:
Is elevated plasma PCSK9 level equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia , irrespective of low-density lipoprotein receptor defects?
### Response:
| Elevated PCSK9 levels are equally detrimental for patients with HeFH or non-FH: a 100-ng/ml increase in PCSK9 will lead to an increase in LDL-C of 0.20 to 0.25 mmol/l in controls and HeFH alike, irrespective of their LDLR mutation. This explains why patients with non-FH or HeFH respond equally well to monoclonal antibo... |
### Instruction:
Does fOXM1 promote the warburg effect and pancreatic cancer progression via transactivation of LDHA expression?
### Response:
| Dysregulated expression and activation of FOXM1 play important roles in aerobic glycolysis and tumorigenesis in patients with pancreatic cancer via transcriptional regulation of LDHA expression. |
### Instruction:
Does the NK1 receptor antagonist N-acetyl-L-tryptophan reduce dyskinesia in a hemi-parkinsonian rodent model?
### Response:
| Daily administration of a SP NK1 receptor antagonist may represent a novel treatment regime that reduces the onset of LID whilst conserving motor function. |
### Instruction:
Do hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson 's disease?
### Response:
| Our results demonstrate that extensive components of the cardiovascular sympathetic system as well as the olfactory system are correlatively impaired in the early stage of PD, suggesting that degeneration of broad aspects of the cardiovascular sympathetic system occurs concurrently with olfactory system degeneration du... |
### Instruction:
Do platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases?
### Response:
| We conclude that the targeting of Aβ42 to rafts in normal cells is a factor that affects its degradation. Critically, pharmacological manipulation of neurons can significantly increase Aβ42 degradation. These results are consistent with the hypothesis that the Aβ-induced production of PAF controls a cholesterol-sensiti... |
### Instruction:
Are tension and force-resistant attachment essential for myofibrillogenesis in Drosophila flight muscle?
### Response:
| Our results demonstrate that force-resistant attachment enables a stark tension increase in the myotendinous system. Subsequently, this tension increase triggers simultaneous myofibril self-assembly throughout the entire muscle fiber. As myofibril and sarcomeric architecture as well as their molecular components are ev... |
### Instruction:
Do brief formalin fixation and rapid tissue processing affect the sensitivity of ER immunohistochemistry of breast core biopsies?
### Response:
| Brief formalin fixation along with rapid processing has no negative effect on the sensitivity of ER-IHC in breast core biopsies. This combination significantly reduces the turnaround time for preparing breast needle biopsy specimens. |
### Instruction:
Does trends in RBC ordering and use after implementing adaptive alert in the electronic computerized physician order entry system?
### Response:
| Electronically generated alerts can reduce but are insufficient to eliminate non-evidence-based transfusions. Analysis of the alerts suggests areas for CPOE improvement. |
### Instruction:
Does deep sequencing reveal myeloma cells in peripheral blood in majority of multiple myeloma patients?
### Response:
| This study highlights the promise of a blood-based, sequencing minimal-residual-disease assay that can be used to measure MM disease burden at different time points and various disease stages. |
### Instruction:
Does vandetanib successfully control medullary thyroid cancer-related Cushing syndrome in an adolescent patient?
### Response:
| We describe the first pediatric case of clinical and biochemical improvement of paraneoplastic MTC-related Cushing syndrome after treatment with vandetanib. Vandetanib and possibly other tyrosine kinase inhibitors may be a novel beneficial option in patients with neuroendocrine tumor-related ectopic Cushing syndrome. |
### Instruction:
Do carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits?
### Response:
| CR-Kp ST258 strains exhibit variability of virulence-associated traits. Differences were associated with the type of KPC gene and CPS. Identification of cross-reacting anti-CPS mAbs encourages their development as adjunctive therapy. |
### Instruction:
Does daidzein stimulate collagen synthesis by activating the TGF-β/smad signal pathway?
### Response:
| The results showed that daidzein treatment can increase skin collagen synthesis and inhibit collagen degradation in vitro and in vivo. It seems that TGF-β/smad signalling pathways play an important role in daidzein-induced collagen accumulation. |
### Instruction:
Do heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway?
### Response:
| Vegf165 activates FLK1-NRP1 signaling in endothelial cells, leading to a PKC-dependent paracrine signal that in turn inhibits epithelial cell apoptosis. |
### Instruction:
Does mulberry leaf extract attenuate oxidative stress-mediated testosterone depletion in streptozotocin-induced diabetic rats?
### Response:
| Our findings indicated that MAE significantly increased Ts production in the diabetic rats, probably through the induction of StAR mRNA expression levels. Administration of MAE to experimental models of diabetes can effectively attenuate oxidative stress-mediated testosterone depletion. |
### Instruction:
Is duration of oral endotracheal intubation associated with dysphagia symptoms in acute lung injury patients?
### Response:
| In ALI survivors, patient-reported, postexubation dysphagia at hospital discharge was significantly associated with upper gastrointestinal comorbidity and a longer duration of oral endotracheal intubation during the first 6 days of intubation. |
### Instruction:
Does aDAMTS-7 expression increase in the early stage of angiotensin II-induced renal injury in elderly mice?
### Response:
| Renal ADAMTS-7 expression was induced by Ang II in elderly mice. The overexpression of ADATMTS-7 might contribute to early inflammatory kidney damage associated with aging. |
### Instruction:
Do three-dimensional and chemical changes on the surface of a 3-year clinically retrieved oxidized titanium dental implant?
### Response:
| While cracks were ubiquitous present from the manufacturing, broken chimney-like structures forming micropores in the clinically retrieved implant may be attributable to excessive mechanical friction forces during the insertion of the implant. Chemical composition of the implant surface may be subjected to changes beca... |
### Instruction:
Are apolipoprotein AII levels associated with the UP/UCr levels in idiopathic steroid-sensitive nephrotic syndrome?
### Response:
| Apolipoprotein AII was detected as a protein associated with the UP/UCr levels in pediatric ISSNS. Our findings present an interesting starting point for further investigation into the pathophysiology of ISSNS. |
### Instruction:
Does xuefuzhuyu decoction inhibition of angiogenesis attenuate liver fibrosis induced by CCl₄ in mice?
### Response:
| XFZY inhibits liver fibrosis not only through inhibiting collagen deposition but also through an antiangiogenic effect on the fibrotic liver. Moreover, the antiangiogenic mechanism of XFZY involves alleviating hypoxia and protecting liver sinusoidal endothelial cell function. |
### Instruction:
Does gold ( I ) N-heterocyclic carbene complex inhibit mouse melanoma growth by p53 upregulation?
### Response:
| The gold (I) N-heterocyclic carbene complex (C22H26N6AuO2PF6) designated as complex 3 induced ROS and p53 dependent apoptosis in B16F10 cells involving the mitochondrial death pathway along with suppression of melanoma tumor growth by regulating the levels of pro and anti apoptotic factors (p53, p21, NF-κB, VEGF and MM... |
### Instruction:
Is patients ' information-seeking activity associated with treatment compliance in inflammatory bowel disease patients?
### Response:
| In Switzerland, IBD patients noncompliant to treatment were more often seeking disease-related information than compliant patients. Daily management of symptoms and disease seemed to be an important concern of those patients. |
### Instruction:
Is recurrent high-grade cervical lesion after primary conization associated with persistent human papillomavirus infection in Norway?
### Response:
| Routine post-conization hr-HPV DNA testing together with cervical cytology may provide a better prediction for potential recurrent disease. Further, primary prevention through adolescent vaccination may prevent CIN2+ and its recurrence. |
### Instruction:
Does functional assessments for predicting a risk of multiple fall in independent ambulatory patients with spinal cord injury?
### Response:
| The FRT may be used as a screening tool to predict risk of multiple falls in independent ambulatory individuals with SCI. However, with a moderate level of specificity, a further comprehensive test may be needed to clearly indicate individuals at a risk of falls. In addition, the findings suggest that a higher level of... |
### Instruction:
Does vitamin D alter genes involved in follicular development and steroidogenesis in human cumulus granulosa cells?
### Response:
| These data suggest that vit D3 alters AMH signaling and steroidogenesis in human cumulus GCs, possibly reflecting a state of GC luteinization potentiation. |
### Instruction:
Is glycation of the complement regulatory protein CD59 a novel biomarker for glucose handling in humans?
### Response:
| We observed robust relationships between a single measurement of blood levels of GCD59 and both acute (2-hour OGTT) and chronic (HbA1c) measures of glucose handling. Lowering of GCD59 levels closely reflected lowering of average weekly glucose within 2 weeks. The role of GCD59 in the diagnosis, management, and vascular... |
### Instruction:
Does late-night salivary cortisol have a better performance than urinary free cortisol in the diagnosis of Cushing 's syndrome?
### Response:
| Our data show that despite similar variability between both methods, LNSF has a superior diagnostic performance than UFC and should be used as the primary biochemical diagnostic test for CS diagnosis. |
### Instruction:
Is overexpression of WRAP53 associated with development and progression of esophageal squamous cell carcinoma?
### Response:
| This report indicates increased expression of WRAP53 in ESCC and that WRAP53 overexpression is correlated with tumor progression. WRAP53 may play a significant role in ESCC; accordingly, WRAP53 could be a useful biomarker for ESCC. |
### Instruction:
Is cSF-1R expression in tumor-associated macrophages associated with worse prognosis in classical Hodgkin lymphoma?
### Response:
| Our data demonstrate that a high number of non-HRS cells expressing CSF-1R are correlated with an increased tumor macrophage content and worse survival. |
### Instruction:
Is dural puncture epidural analgesia superior to continuous labor epidural analgesia?
### Response:
| DPE technique did not provide superior labor analgesia as compared to CLE technique. Technically, fewer immediate failures in labor analgesia but higher incidence of paresthesias were observed with DPE technique. |
### Instruction:
Does soy food frequency questionnaire correlate with baseline isoflavone levels in patients with bladder cancer?
### Response:
| The soy food frequency questionnaire did not correlate with plasma or urine concentrations of either isoflavone. |
### Instruction:
Is increase in QRS amplitudes better than N-terminal pro-B-type natriuretic peptide to predict clinical improvement in decompensated heart failure?
### Response:
| Increase in QRS voltages especially in aVR was found to be more sensitive than NT-proBNP to predict clinical improvement in DHF. |
### Instruction:
Do variants associated with susceptibility to pancreatic cancer and melanoma reciprocally affect risk?
### Response:
| Reported variants of melanoma genes and pathways do not play a role in pancreatic cancer predisposition. Reciprocally, pancreatic cancer susceptibility variants are not associated with melanoma risk. |
### Instruction:
Does pre-radiotherapy FDG PET predict radiation pneumonitis in lung cancer?
### Response:
| The pretreatment pulmonary FDG uptake, as quantified by the SUV(95), predicted symptoms of RP in this study. Elevation in this pre-treatment biomarker identifies a patient group at high risk for post-treatment symptomatic RP. |
### Instruction:
Do cerebral cavernous malformations arise independent of the heart of glass receptor?
### Response:
| These findings suggest that the HEG-CCM signaling functions during cardiovascular development and growth, whereas CCMs arise because of loss of HEG-independent CCM signaling in the endothelium of the central nervous system after birth. |
### Instruction:
Do practice to minimize the use of blood products improve outcome after hepatic resection for hepatocellular carcinoma?
### Response:
| Practice to minimize the use of blood products may improve patient's survival after hepatic resection for HCC. |
### Instruction:
Does ulinastatin activate the renin-angiotensin system to ameliorate the pathophysiology of severe acute pancreatitis?
### Response:
| This study shows that ulinastatin has differential effects on the two axes of the RAS during SAP. Our results further suggest that upregulation of components of the ACE2-Ang-(1-7)-Mas pathway might be an important mechanism contributing to the therapeutic role of ulinastatin in alleviating pancreatitis-associated sympt... |
### Instruction:
Does artemisia capillaris inhibit atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice?
### Response:
| Our results suggest that AC should be explored as a potential therapeutic agent to treat atopic dermatitis and analysis by HPLC will help to improve the quality of AC. |
### Instruction:
Is blood pressure control similar in treated hypertensive patients with optimal or with high-normal albuminuria?
### Response:
| Lack of BP control is more prevalent among patients with microalbuminuria than in patients with normoalbuminuria. No significant difference was seen between patients with optimal or high-normal UAE. |
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