question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does inhibition of microRNA miR-92a induce apoptosis and necrosis in human acute promyelocytic leukemia?
### Response:
| These findings suggest the inhibition of miR-92a as a novel approach for treatment of Acute Promyelocytic Leukemia (APL). |
### Instruction:
Is `` IDEAL '' aging associated with lower resting metabolic rate : the Baltimore Longitudinal Study of Aging?
### Response:
| Individuals who are fully functional and free of major medical conditions have lower RMR than those with disease and functional impairments. These findings suggest that health status plays a role in energy use and regulation independent of age and body composition and that elevated RMR may be a global biomarker of poor... |
### Instruction:
Does roflumilast N-oxide reverse corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease?
### Response:
| RNO reverses corticosteroid resistance and shows strong anti-inflammatory effects alone or in combination with corticosteroids on neutrophils from patients with COPD. |
### Instruction:
Does pelvic incidence-lumbar lordosis mismatch result in increased segmental joint loads in the unfused and fused lumbar spine?
### Response:
| Higher adjacent segment shear forces in alignments at risk for ASD already prior to fusion provide a mechanistic explanation for the clinically observed correlation between PILL mismatch and rate of adjacent segment degeneration. |
### Instruction:
Does meta-tetrahydroxyphenyl chlorine mediated photodynamic therapy inhibit the migration and invasion of a nasopharyngeal carcinoma KJ-1 cell line?
### Response:
| This study demonstrates that a sublethal dose of m-THPC PDT inhibits the migration and invasion of nasopharyngeal carcinoma cells in vitro. |
### Instruction:
Does identity-by-descent-guided mutation analysis and exome sequencing in consanguineous families reveal unusual clinical and molecular findings in retinal dystrophy?
### Response:
| Our study emphasized that identity-by-descent-guided mutation analysis and/or whole-exome sequencing are powerful tools for the molecular diagnosis of retinal dystrophy. Our approach uncovered unusual molecular findings and unmasked syndromic retinal dystrophies, guiding future medical management. Finally, elucidating ... |
### Instruction:
Is partial acute transverse myelitis a predictor of multiple sclerosis in children?
### Response:
| Acute partial transverse myelitis and brain MRI abnormalities at initial presentation are significantly predictive of a subsequent diagnosis of MS in children with ATM. These findings suggest that closer brain MRI monitoring after acute partial transverse myelitis might make the earlier introduction of disease-modifyin... |
### Instruction:
Does inhibition of p38 mitogen-activated protein kinase attenuate butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model?
### Response:
| p38 MAPK can be activated by butyrate and is involved in the butyrate-induced apoptosis and impairment of intestinal barrier function. Inhibition of p38 MAPK can significantly attenuate butyrate-induced intestinal barrier dysfunction. |
### Instruction:
Is obesity associated with higher 4E-BP1 expression in endometrial cancer?
### Response:
| The activation of 4E-BP1 was higher in the obese women with EC. Adiposity may be a key factor to consider in future studies investigating the role of 4E-BP1 as a biomarker and therapeutic target in EC. |
### Instruction:
Does disruption of polycomb repressor complex-mediated gene silencing reactivate HIV-1 provirus in latently infected cells?
### Response:
| This study shows that PRC is strongly related to the control of HIV-1 latency and that PRC-breaking agents may be helpful for purging HIV-1 from latent reservoirs. |
### Instruction:
Are epidermal growth factor receptor gene polymorphisms associated with prognostic features of breast cancer?
### Response:
| The data suggest that the presence of the variant forms of EGFR polymorphisms may lead to better prognosis in breast cancer, especially in patients with luminal A tumors. |
### Instruction:
Is allopurinol an independent determinant of improved arterial stiffness in chronic kidney disease : a cross-sectional study?
### Response:
| In patients with CKD, use of allopurinol is independently associated with lower arterial stiffness. This study provides further justification for a large definitive randomised controlled trial examining the therapeutic potential of allopurinol to reduce cardiovascular risk in people with CKD. |
### Instruction:
Is islet amyloid polypeptide a target antigen for CD8+ T-cells in type 2 diabetes?
### Response:
| It is unlikely that IAPP would be a target for CD8+ T-cells in diabetic patients; however, the trend observed toward a lower response of T2D patients against IAPP and common viral peptides may imply a decreased immune response in these patients. |
### Instruction:
Does thrombin promote fibronectin secretion by bone marrow mesenchymal stem cells via the protease-activated receptor mediated signalling pathways?
### Response:
| Thrombin could promote FN secretion by MSCs via PAR-mediated ERK 1/2 activation, while NF kappa B might be also involved in an undefined manner. |
### Instruction:
Is neglect performance in acute stroke related to severity of white matter hyperintensities?
### Response:
| More severe leukoaraiosis is associated with more hemispatial neglect after acute ischemic stroke, independent of infarct volume, age and sex. We found not only more frequent neglect but also more severe neglect, based on error rates on neglect tests, in individuals with increasing leukoaraiosis. This emphasizes the im... |
### Instruction:
Do iL-12 and IL-27 regulate the phagolysosomal pathway in mycobacteria-infected human macrophages?
### Response:
| Our results have identified novel influences of IL-12, IL-27, and STAT-3 on lysosomal activity and further demonstrate that modulating the cytokine environment promotes enhanced trafficking of mycobacteria to lysosomes in human macrophages. This has important implications in approaches to control infection and improve ... |
### Instruction:
Is eIF5A2 a novel chemoresistance gene in breast cancer?
### Response:
| This study shows that eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells. |
### Instruction:
Is pore volume most highly correlated with the visual assessment of skin pores?
### Response:
| High correlation between pore score and pore volume can be explained by 3-D structural characteristics of pores. It is concluded that pore volume and area serve as useful parameters in estimating pore of skin surface. |
### Instruction:
Does intrathecal morphine increase the incidence of urinary retention in orthopaedic patients under spinal anaesthesia?
### Response:
| Patients receiving spinal anaesthesia with a 0.5% hyperbaric solution of bupivacaine combined with intrathecal morphine were demonstrated to have a higher incidence of urinary catheterisation, longer time to urinary catheterisation and longer time to miction compared to patients receiving only local anaesthetics. |
### Instruction:
Do preferences for blood-based colon cancer screening differ by race/ethnicity?
### Response:
| Blood-based screening for CRC was widely favored. Future research on medical decision-making should examine the basis for racial/ethnic differences in biomarker screening preferences. |
### Instruction:
Do mesenchymal stem cells repair germinal cells of seminiferous tubules of sterile rats?
### Response:
| We concluded that testis of host infertile rats accepted transplanted MSCs. The transplanted MSCs could differentiate into germinal cells in testicular seminiferous tubules. This article extracted from M.Sc. Thesis. (Bentolhoda Fereydouni). |
### Instruction:
Does exenatide improve hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats?
### Response:
| In addition to reducing appetite, enhanced lipid use by exenatide in adipose tissue may reduce hepatic lipid content in NAFLD, most likely by decreasing lipid influx into the liver. |
### Instruction:
Does sodium alginate ameliorate indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats?
### Response:
| These results indicate that AL-Na ameliorates non-steroidal anti-inflammatory drug-induced small intestinal enteritis via bacterial translocation. |
### Instruction:
Do aTG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn 's disease patients?
### Response:
| Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants. This could be part of the pathophysiological mechanism resulting in the disease. |
### Instruction:
Does prevalence of tick-borne encephalitis virus in Ixodes ricinus tick in northern Europe with particular reference to Southern Sweden?
### Response:
| If the ratio of nymphs to adult ticks in the TBEV-analysed sample differs from that in the I. ricinus population in the field, the MIR obtained will not necessarily reflect the TBEV prevalence in the field. The relatively low TBEV prevalence in the potential vector population recorded in most studies may partly be due ... |
### Instruction:
Does low-protein formula slow weight gain in infants of overweight mothers?
### Response:
| A low-protein formula with probiotics slowed weight gain between 3 and 6 months in infants of overweight mothers. Weight gain and biomarkers were more like those of breast-fed infants. |
### Instruction:
Is pressure-controlled mechanical ventilation more advantageous in the follow-up of patients with chronic obstructive pulmonary disease after open heart surgery?
### Response:
| There is not a single widely accepted and established mode of ventilation for patients with COPD undergoing open-heart surgery. Our modest experience indicated promising results with PCV mode; however, further studies are warranted. |
### Instruction:
Are cervicovaginal levels of proinflammatory cytokines increased during chlamydial infection in bacterial vaginosis but not in lactobacilli-dominated flora?
### Response:
| Detection of endocervical CT is associated with increased cervicovaginal IL-1β, IL-6, and IL-8 levels in women with concomitant BV but not in those with normal flora. |
### Instruction:
Do performance measures rather than self-report measures of functional status predict home care use in community-dwelling older adults?
### Response:
| This study suggests that standardized performance measures-in particular, the PASS-are more predictive of formal HC use in community-dwelling older adults than self-report measures. |
### Instruction:
Are adiposity , physical activity , and muscle quality independently related to physical function performance in middle-aged postmenopausal women?
### Response:
| In postmenopausal women, a more optimal body composition (including lower adiposity and higher lean mass) and higher levels of physical activity are associated with better physical function performance at midlife. |
### Instruction:
Is autophagy-related IRGM polymorphism associated with mortality of patients with severe sepsis?
### Response:
| The data suggest that the IRGM(+313), an autophagy-related polymorphic locus, influences outcome in severely septic patients, with the possible involvement of autophagy in sepsis exacerbation. |
### Instruction:
Is eRG protein expression in diagnostic specimens associated with increased risk of progression during active surveillance for prostate cancer?
### Response:
| A total of 121 of 142 ERG-negative and 96 of 123 ERG-positive patients had complete diagnostic information. In competing risk models, the ERG-positive group showed significantly higher incidences of overall AS progression (p<0.0001) and of the subgroups PSA progression (p<0.0001) and histopathologic progression (p<0.00... |
### Instruction:
Does serum ficolin-2 correlate worse than fecal calprotectin and CRP with endoscopic Crohn 's disease activity?
### Response:
| Ficolin-2 serum levels correlate worse with endoscopic CD activity when compared to fecal calprotectin or CRP. |
### Instruction:
Is preoperative platelet lymphocyte ratio ( PLR ) superior to neutrophil lymphocyte ratio ( NLR ) as a predictive factor in patients with esophageal squamous cell carcinoma?
### Response:
| Preoperative NLR and PLR were significant predictors of overall survival in patients with ESCC. However, PLR is superior to NLR as a predictive factor in patients with ESCC. |
### Instruction:
Does prostitution use have non sexual functions - case report of a depressed psychiatric out-patient?
### Response:
| Exploring and understanding prostitution consumption patterns in young men can benefit the treatment of psychiatric disorders in the private practice setting. It is the psychiatrists task to investigate the patients hidden motives behind paid sex use to help patients achieve a greater inner and relational freedom. |
### Instruction:
Does vitamin D supplementation improve human skeletal muscle contractile properties in insufficient young males?
### Response:
| Elevating total serum 25[OH]D to concentrations > 120 nmol L(-1) has no effect on skeletal muscle function. We postulate that skeletal muscle function is only perturbed in conditions of severe deficiency (<12.5 nmol L(-1)). |
### Instruction:
Does streptococcus pneumoniae worsen cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα?
### Response:
| S. pneumoniae infection augments atherosclerosis and exacerbates ischemic brain injury via IL-1 and platelet-mediated systemic inflammation. These mechanisms may contribute to diverse cardio- and cerebrovascular pathologies in humans. |
### Instruction:
Does enzymatic digestion improve testicular sperm retrieval in non-obstructive azoospermic patients?
### Response:
| The combination of conventional TESE and enzymatic digestion is an effective method to recover spermatozoa. The benefit of the mincing combined with enzyme to sperm retrieval for NOA firstly shorten the mechanical searching time, leading to minimizing further cellular damage as well as exposure to external conditions, ... |
### Instruction:
Does curcumin inhibit endometriosis endometrial cells by reducing estradiol production?
### Response:
| In summary, in this study we found that E2 is important in ectopic endometrium, and epithelial cell is in dominant position with E2 secretion. Curcumin was able to suppress the proliferation of endometrial cells by reducing the E2 value. |
### Instruction:
Does computer-aided detection improve detection of pulmonary nodules in chest radiographs beyond the support by bone-suppressed images?
### Response:
| CAD improved radiologists' performance for the detection of lung nodules on chest radiographs, even when baseline performance was optimized by providing lateral radiographs and BSIs. Still, most of the true-positive CAD candidates are dismissed by observers. |
### Instruction:
Does large-scale brain network coupling predict acute nicotine abstinence effects on craving and cognitive function?
### Response:
| Alterations in coupling of the salience and default mode networks and the inability to disengage from the default mode network may be critical in cognitive/affective alterations that underlie nicotine dependence. |
### Instruction:
Are core symptoms not meeting criteria for delirium associated with cognitive and functional impairment and mood and behavior problems in older long-term care residents?
### Response:
| CAM-defined core symptoms of delirium not meeting criteria for delirium appear to be associated with cognitive and functional impairment and mood and behavior problems in LTC residents with or without dementia. These findings may have implications for the prevention and management of such impairments and problems in LT... |
### Instruction:
Do distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients?
### Response:
| It is possible to separate patients with infectious inflammation from those with sterile inflammation based on inflammatory mediator patterns. This strategy could be developed into a decision-making tool for diverse clinical applications. |
### Instruction:
Does t-cell activation discriminate subclasses of symptomatic primary humoral immunodeficiency diseases in adults?
### Response:
| These results highlight the importance of T-cell activation that may improve discrimination of PHID patients in specific subgroups and help to identify patients with different clinical outcomes. |
### Instruction:
Are females more anxious than males : a metacognitive perspective?
### Response:
| Metacognitive beliefs in uncontrollability, advantages and avoidance of worry may contribute to the higher prevalence of anxiety in females than males. |
### Instruction:
Do opioids use in male population referred for mandatory urine opioid screen before marriage in shiraz-iran?
### Response:
| It can be concluded that at least 1.80% of men referred for UOS as a mandatory test before marriage used opioids. These results should be considered when preventive and therapeutic programs are being planned. |
### Instruction:
Does sMAD4 loss trigger the phenotypic changes of pancreatic ductal adenocarcinoma cells?
### Response:
| This study revealed the molecular basis for SMAD4-dependent differences in PDAC with the aim of identifying the subset of patients likely to respond to therapies targeting the TGF-β or EGFR signaling pathways and of identifying potential therapeutic interventions for PDAC patients with SMAD4 defects. |
### Instruction:
Is childhood abuse associated with methylation of multiple loci in adult DNA?
### Response:
| Our observed genome-wide methylation profiles in adult DNA associated with childhood abuse justify the further exploration of epigenetic regulation as a mediating mechanism for long-term health outcomes. |
### Instruction:
Does silencing of hepcidin enforce the apoptosis in iron-induced human cardiomyocytes?
### Response:
| Our findings suggest that hepcidin can rescue human cardiomyocytes from iron-induced apoptosis through the regulation of GATA-4/Bcl-2 and the extrinsic apoptotic pathway. |
### Instruction:
Is microRNA-484 more highly expressed in serum of early breast cancer patients compared to healthy volunteers?
### Response:
| In this study, we found that miR-484 is significantly differentially expressed in serum of early breast cancer patients compared to healthy volunteers. We did not however find any correlation between miR-484 levels with histopathological parameters of the breast cancers. With further studies, miR-484 may prove useful a... |
### Instruction:
Does salusin-β not salusin-α promote vascular inflammation in ApoE-deficient mice via the I-κBα/NF-κB pathway?
### Response:
| Salusin-β, but not salusin-α, promotes vascular inflammation in apoE-deficient mice via the I-κBα/NF-κB pathway. These findings provide further insight into the mechanism of salusins in atherosclerosis and potential targets for the prevention and treatment of atherosclerosis. |
### Instruction:
Is peritransplant lymphopenia a novel prognostic factor in recurrence of hepatocellular carcinoma after liver transplantation?
### Response:
| Peritransplant lymphopenia is a powerful prognostic factor for the recurrence of HCC after LT, which suggests that maintaining ALCs in LT patients might improve cancer outcome. |
### Instruction:
Does kidney function before pancreas transplant alone predict subsequent risk of end-stage renal disease?
### Response:
| Kidney function before PTA is a strong independent predictor of ESRD. These results may inform patient selection and the use of targeted interventions to reduce the risk of progressive kidney impairment in this patient population. |
### Instruction:
Does suberoylanilide hydroxamic acid ( SAHA ) enhance olaparib activity by targeting homologous recombination DNA repair in ovarian cancer?
### Response:
| These results provide preclinical rationale for targeting DNA damage response pathways by combining small molecule PARPi with HDACi as a mechanism for reducing HR efficiency in ovarian cancer. |
### Instruction:
Is elevated interleukin-32 expression associated with Helicobacter pylori-related gastritis?
### Response:
| IL-32 level is elevated in patients with H. pylori infection and its expression is regulated by proinflammatory stimuli, suggesting that IL-32 may play a role in the pathogenesis of H. pylori-related gastritis. |
### Instruction:
Do ratios derived from an array of standard haematological indices predict the oncological outcome in colon cancer?
### Response:
| This is the first study to apply recursive partitioning in determining the relationship between haematological ratios and OS in colon cancer. Haematological ratios were predictive of oncological outcome. What does this paper add to the literature? This study suggests an association between systemic inflammation and onc... |
### Instruction:
Do single-dose live-attenuated Nipah virus vaccines confer complete protection by eliciting antibodies directed against surface glycoproteins?
### Response:
| The rVSV vectors expressing Nipah virus G or F are prime candidates for new 'emergency vaccines' to be utilized for NiV outbreak management. |
### Instruction:
Do soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells?
### Response:
| Human AEC CM treatment suppresses markers of activation, proliferation and fibrosis in human HSCs as well as inducing apoptosis and reducing proliferation. Human AEC CM treatment may be effective in ameliorating liver fibrosis and warrants further study. |
### Instruction:
Does presence of small parathyroid glands in renal transplant patients support less-than-total parathyroidectomy to treat hypercalcemic hyperparathyroidism?
### Response:
| Surgeons performing PT should be aware of the high frequency of small and less diseased PG in RTX patients. In this context, TPT+AT might overtreat hypercalcemic hyperparathyroidism in RTX patients, especially when small PG are present. |
### Instruction:
Are endoscopic transpapillary biopsies of limited value in the diagnostics of bile duct strictures of unknown etiology-results of a histopathologically controlled study in 312 patients?
### Response:
| ETP alone is not reliable enough in diagnosing bile duct malignancies as shown by low sensitivity and accuracy rates (false-negative rate of 32%). |
### Instruction:
Does preoperative oral feeding reduce stress response after laparoscopic cholecystectomy?
### Response:
| Preoperative feeding has advantage over overnight fasting by reducing preoperative discomfort in patients after laparoscopic cholecystectomy. In fed patients, smaller increase in C-reactive protein and better regulation of cortisol levels are an indicator of decreased perioperative stress response. |
### Instruction:
Is diabetes associated with lower tuberculosis antigen-specific interferon gamma release in Tanzanian tuberculosis patients and non-tuberculosis controls?
### Response:
| Diabetes is associated with lower levels of Mtb antigen-specific IFN-γ, and the validity of IFN- γ tests for LTBI may be questionable in individuals with diabetes. |
### Instruction:
Does sIRT6 regulate the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts?
### Response:
| Cigarette smoke induces pro-inflammatory and matrix-destructive responses in RASF. Cigarette smoke enhances the expression of SIRT6 in vitro and in vivo. TNFα increases the levels of SIRT6. SIRT6 diminishes MMP1 production under cigarette smoke extract and TNFα stimulation. |
### Instruction:
Is hepatitis delta a major determinant of liver decompensation events and death in HIV-infected patients?
### Response:
| Hepatitis delta is associated with a high rate of death and liver decompensation events in HIV-infected patients on ART. |
### Instruction:
Does experimental heart failure induce alterations of the lung proteome -- insight into molecular mechanisms?
### Response:
| Experimental heart failure profoundly alters the pulmonary proteome. Our results supplement the current knowledge of pulmonary stress failure by specifying its molecular fundament. |
### Instruction:
Do the TLR2 ligand FSL-1 and the TLR5 ligand Flagellin mediate pro-inflammatory and pro-labour response via MyD88/TRAF6/NF-κB-dependent signalling?
### Response:
| TLR2 engagement by the synthetic lipoprotein FSL-1 and TLR5 engagement by bacterial flagellin enhances pro-inflammatory and pro-labour mediators in human fetal membranes and myometrium via MyD88/TRAF6/NF-κB. |
### Instruction:
Do comparison of tympanic membrane grafting medial or lateral to malleus handle?
### Response:
| Both techniques (medial and lateral to malleus handle) of TM grafting are effective with success rates 96.42% and 92.85% respectively. |
### Instruction:
Does commiphora mukul attenuate peripheral neuropathic pain induced by chronic constriction injury of sciatic nerve in rats?
### Response:
| Therefore, the present study suggests that CM may be used in future as a treatment option for neuropathic pain. |
### Instruction:
Does premedication with oral tramadol reduce severity of postoperative shivering after general anesthesia?
### Response:
| The overall prevalence of PAS was not significantly different in the two study groups, but the higher grades of shivering which needed treatment were significantly lower in the tramadol group than in the placebo, and those patients who received tramadol experienced milder form of shivering. It is suggested that higher ... |
### Instruction:
Is e2F1 a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network?
### Response:
| E2F1 is a fibrogenic gene and could serve as a potential new diagnostic marker for nonalcoholic and alcoholic liver fibrosis/cirrhosis. |
### Instruction:
Do baculovirus vector-mediated transfer of sodium iodide symporter and plasminogen kringle 5 genes for tumor radioiodide therapy?
### Response:
| The recombinant baculovirus supports a promising strategy of NIS-based raidoiodide therapy combined with K5-based antiangiogenic therapy by targeting both the tumor and its supporting vessels. |
### Instruction:
Is a Halloween gene shadow a potential target for RNA-interference-based pest management in the small brown planthopper Laodelphax striatellus?
### Response:
| The ecdysteroidogenic pathway is conserved in L. striatellus. Lssad can serve as a possible target for dsRNA-based pesticides for planthopper control. |
### Instruction:
Does cannabidiol enhance microglial phagocytosis via transient receptor potential ( TRP ) channel activation?
### Response:
| The TRPV-dependent phagocytosis-enhancing effect of CBD suggests that pharmacological modification of TRPV channel activity could be a rational approach to treating neuroinflammatory disorders involving changes in microglial function and that CBD is a potential starting point for future development of novel therapeutic... |
### Instruction:
Are rAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 new prognostic biomarkers in serous epithelial ovarian cancer?
### Response:
| In this systematic study, we show that RAN and two protein partners involved in its nucleo-cytoplasmic and mitotic functions (XPO7 and TPX2, respectively) can be used as biomarkers to stratify patients based on prognosis. In particular, we reported for the first time the clinical relevance of the exportin XPO7 and show... |
### Instruction:
Are multiple good options available for achalasia management?
### Response:
| MT options are available for management of achalasia. Improvement of clinical symptoms and overall patient satisfaction does not differ if the patient underwent an ST modality or a combination of different treatments. |
### Instruction:
Does microRNA-145 inhibit tumour growth and metastasis in colorectal cancer by targeting fascin-1?
### Response:
| MiR-145 has a critical role in the inhibition of invasive and metastatic capacities of CRC, probably through directly targeting Fascin-1. This miRNA may be involved in the development and progression of CRC. |
### Instruction:
Is notch1 activation a poor prognostic factor in patients with gastric cancer?
### Response:
| Notch1 activation was correlated with gastric cancer progression and defined as a novel independent prognostic factor. Combining ICN1 expression with TNM stage may provide a better predictive model for outcomes of gastric cancer patients. |
### Instruction:
Is acquisition of epithelial-mesenchymal transition associated with Skp2 expression in paclitaxel-resistant breast cancer cells?
### Response:
| These findings suggest that Skp2 was critically involved in PR-mediated EMT. Skp2 could be a potential therapeutic target for breast cancer. |
### Instruction:
Does breast cancer metastasis suppressor-1 promoter methylation in cell-free DNA provide prognostic information in non-small cell lung cancer?
### Response:
| Methylation of BRMS1 promoter in cfDNA isolated from plasma of NSCLC patients provides important prognostic information and merits to be further evaluated as a circulating tumour biomarker. |
### Instruction:
Does a new oxovanadium complex enhance renal function by improving insulin signaling pathway in diabetic mice?
### Response:
| The new oxovanadium complex, with 3,5-dimethyl-pyrazolyl ligand, improves kidney function in diabetic mice, and its mechanism may involve regulation of the insulin signaling pathway. |
### Instruction:
Is hepatic toll-like receptor 4 expression associated with portal inflammation and fibrosis in patients with NAFLD?
### Response:
| TLR4 expression by regenerating and inflammatory cells at the porto-septal and interface level, favoured by increased LPS activity, is associated with activation of fibrogenic cells and the degree of fibrosis. |
### Instruction:
Is reintervention following endovascular abdominal aneurysm repair uncommon after five-years : results of greater than a decade follow-up?
### Response:
| Stable long-term aneurysm exclusion was achieved in the majority of patients with most re-interventions occurring early in the follow up period. Whilst life-long surveillance should be continued, these data raise the question of the appropriate duration of CT surveillance and suggest that EVAR should be considered for ... |
### Instruction:
Does preoperative Cylex assay predict rejection risk in patients with kidney transplant?
### Response:
| For the first time, we have evidence that a preoperative ImmuKnow level can stratify patients with KT into low/high risk groups for rejection. Future studies used to assess the utility of this assay to design individualized immunosuppressive regimens are required. |
### Instruction:
Is epithelial-mesenchymal transition during invasion of cutaneous squamous cell carcinoma paralleled by AKT activation?
### Response:
| AKT may serve as a therapeutic target to avoid dissemination of cSCC cells. |
### Instruction:
Does adipose tissue dendritic cells enhance inflammation by prompting the generation of Th17 cells?
### Response:
| Our results indicate the existence of CD11c+ DCs in adipose tissues, which displays an immature phenotype but possessing pro-inflammatory function. |
### Instruction:
Does zonisamide decrease current-source density of high Beta frequency of electroencephalogram?
### Response:
| The CSD changes suggest ZNS may diminish the activity of cerebral networks related to verbal fluency. |
### Instruction:
Does structural interrogation of phosphoproteome identified by mass spectrometry reveal allowed and disallowed regions of phosphoconformation?
### Response:
| While MS is a stand-alone technique for the identification of vast majority of phosphorylation events, identifications within disallowed region of conformation will benefit from techniques that independently probe for phosphorylation and protein dynamics. Our studies also imply that trapping alternate protein conformat... |
### Instruction:
Is angiographic embolization an effective treatment of severe hemorrhage in pancreatitis?
### Response:
| Angiographic embolization is an effective treatment of the life-threatening bleeding that occurs secondary to pancreatitis. |
### Instruction:
Does farnesyltransferase regulate neutrophil recruitment and tissue damage in acute pancreatitis?
### Response:
| These results demonstrate that farnesyltransferase signaling plays a significant role in AP by regulating neutrophil infiltration and tissue injury via the neutrophil expression of macrophage-1 antigen. Thus, our findings not only elucidate novel signaling mechanisms in pancreatitis but also suggest that farnesyltransf... |
### Instruction:
Does zinc therapy improve adverse effects of long term administration of copper on epididymal sperm quality of rats?
### Response:
| Adverse effects of long term consumption of copper on sperm quality could be prevented by zinc therapy in rats. |
### Instruction:
Is accumulation of non-traditional risk factors for coronary heart disease associated with incident coronary heart disease hospitalization and death?
### Response:
| Both traditional and non-traditional risk factor indices are independently associated with incident CHD events. CHD risk assessment may benefit from consideration of general health information as well as from traditional risk factors. |
### Instruction:
Do palatal mucosa derived fibroblasts present an adaptive behavior regarding cytokine secretion when grafted onto the gingival margin?
### Response:
| Fibroblasts from the palatal mucosa seem to be adapted to local conditions of the site microenvironment when grafted onto the gingival marginal area. This evidence supports the effective participation of fibroblasts in the homeostasis of the marginal periodontium through secretion modulation of important inflammatory m... |
### Instruction:
Is soluble CD25 increased in patients with sepsis-induced acute kidney injury?
### Response:
| These results suggest that immune suppression in sepsis may be closely linked to the development of AKI and that sCD25 or IL-10 may be useful as novel biomarkers for the development of septic AKI. |
### Instruction:
Does bear bile powder ( 熊胆粉 ) induce apoptosis of human hepatocellular carcinoma cells via mitochondrion-dependent pathway?
### Response:
| BBP could inhibit the growth of HepG2 hepatocellular cancer cells through mitochondrion-mediated apoptosis, which may, in part, explain its anti-cancer activity. BBP may be a potential novel therapeutic agent for the treatment of hepatocellular carcinoma. |
### Instruction:
Is despite a lack of otoacoustic emission , word recognition seriously influenced in a TECTA DFNA8/12 family?
### Response:
| Although the missense p.Y1870C TECTA mutation leads to complete failure of the cochlear amplifier in humans, very high speech perception scores can be achieved with appropriate therapy. |
### Instruction:
Is neutrophil to lymphocyte ratio associated with more extensive , severe and complex coronary artery disease and impaired myocardial perfusion?
### Response:
| N/L is associated with severe, extensive and complex CAD and may be used to predict moderate to severe involvement in patients with CAD. |
### Instruction:
Do [ Family-based behavioral treatment for obese children - results and two year follow up ]?
### Response:
| Epstein´s family-based behavioural treatment showed promising effects on weight status, and emotional as well as physical markers, both in the short and long term in a clinical sample of obese Icelandic children. |
### Instruction:
Do loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis?
### Response:
| These results indicate that FLG mutations might be involved in the pathogenesis of WDEIA in the present case. |
### Instruction:
Does segregation analysis suggest that keratoconus is a complex non-mendelian disease?
### Response:
| Complex segregation analysis indicates a strong genetic contribution to the transmission of keratoconus. Inheritance is most probably due to a non-mendelian major gene effect. Low genotype-phenotype correlation in sporadic KC families can make linkage studies difficult, thus genome wide association studies, epigenetic ... |
### Instruction:
Does regulation of O2 consumption by the PI3K and mTOR pathways contribute to tumor hypoxia?
### Response:
| Targeting the PI3K/mTOR pathway substantially reduces mitochondrial oxygen consumption thereby reducing tumor hypoxia. These alterations in tumor hypoxia should be considered in the design of clinical trials using PI3K/mTOR inhibitors, particularly in conjunction with radiotherapy. |
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