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### Instruction:
Does eye closure cause widespread low-frequency power increase and focal gamma attenuation in the human electrocorticogram?
### Response:
| Eye closure (1) affects a broad range of frequencies outside the α band and (2) involves a distributed network of neural activity in anatomical areas outside visual cortex. |
### Instruction:
Do pain severity and pain catastrophizing predict functional disability in youth with inflammatory bowel disease?
### Response:
| Greater attention to the role of pain catastrophizing in contributing to functional disability in youth with IBD may be important given that pain-related cognitions are modifiable via intervention. |
### Instruction:
Are t cells but not NK cells associated with a favourable outcome for resected colorectal liver metastases?
### Response:
| T cells, but not NK cells, are preferentially recruited to colorectal liver metastases. NK cells within colorectal metastases have an intrahepatic and potentially tolerogenic, rather than a peripheral, phenotype. Similar to primary tumours, the magnitude of the T cell infiltrate in colorectal metastases is positively a... |
### Instruction:
Are fibroblast growth factor receptor splice variants stable markers of oncogenic transforming growth factor β1 signaling in metastatic breast cancers?
### Response:
| The results of our study strongly suggest that FGFR1-β is required for the pulmonary outgrowth of metastatic BC. Moreover, FGFR1 isoform expression can be used as a predictive biomarker for therapeutic application of its kinase inhibitors. |
### Instruction:
Is lower corticosteroid skin blanching response associated with severe COPD?
### Response:
| In this study, severe and very severe COPD patients had lower skin corticosteroid sensitivity than mild and moderate COPD patients and non-COPD controls with comparable age and packyears. Our findings together suggest that the reduced skin blanching response fits with a subgroup of COPD patients that has an early-onset... |
### Instruction:
Does whole exome sequencing in Thai patients with retinitis pigmentosa reveal novel mutations in six genes?
### Response:
| This is the first report of mutations in Thai RP patients. These findings are useful for genotype-phenotype comparisons among different ethnic groups. |
### Instruction:
Does endothelin receptor-A antagonist attenuate retinal vascular and neuroretinal pathology in diabetic mice?
### Response:
| Endothelin-A receptor blockade using atrasentan significantly reduces the vascular and neuroretinal complications in diabetic mice. Endothelin-A receptor blockade is a promising therapeutic target in diabetic retinopathy. |
### Instruction:
Does the Rpe65 rd12 allele exert a semidominant negative effect on vision in mice?
### Response:
| The rd12 lesion is in Rpe65. The rd12 mutant phenotype inherits in a semidominant manner. The effects of the mutant mRNA on visual function may result from inefficient binding to ribosomes for translation. |
### Instruction:
Do superficial mycoses at the Hospital do Servidor Público Municipal de São Paulo between 2005 and 2011?
### Response:
| The biota consisted of six dermatophyte species: T. rubrum, T. mentagrophytes, M. gypseum, T. tonsurans, E. floccosum, and M. canis. The most common site of involvement was the nail and foot in adults and scalp in children, with a female predominance. Both Candida and Malassezia were more prevalent in adult women, the ... |
### Instruction:
Does low-dose acetazolamide reverse periventricular white matter hyperintensities in iNPH?
### Response:
| These preliminary findings provide new evidence that low-dose acetazolamide can reduce PVH and may improve gait in iNPH. PVH volume, reflecting transependymal CSF, is shown to be a potential MRI indicator of pharmacologic intervention effectiveness. Further studies of pharmacologic treatment of iNPH are needed and may ... |
### Instruction:
Are plasma inflammatory and apoptosis markers associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy?
### Response:
| Elevated plasma concentrations of inflammatory and apoptosis biomarkers are associated with RRT dependence and death. Our data suggest that future interventions should investigate broad-spectrum immune-modulation to improve outcomes. |
### Instruction:
Is cortical N-acetyl aspartate a predictor of long-term clinical disability in multiple sclerosis?
### Response:
| Cortical NAA/Cr in early RRMS correlated with clinical disability after 2 and 7 years and may be used as a predictor of long-term disease outcome. |
### Instruction:
Is platelet count measured prior to cancer development a risk factor for future symptomatic venous thromboembolism : the Tromsø Study?
### Response:
| In conclusion, pre-cancer platelet count was associated with risk of symptomatic venous thromboembolism in cancer patients, but not in cancer-free subjects. Our findings suggest that platelet count and platelet-leukocyte interactions may play a role in the pathogenesis of cancer-related venous thromboembolism. |
### Instruction:
Does contrast-enhanced ultrasound identify reduced overall and regional renal perfusion during global hypoxia in piglets?
### Response:
| Global hypoxia induced changes in overall and regional renal perfusion detectable with CEUS. Cortical and medullary flows were affected differently by hypoxia; a strong increase in medullary TTP and MTT was observed, indicating a reduction in medullary blood flow velocity. In the cortex, a significant reduction in PI w... |
### Instruction:
Do simple manoeuvre to reduce the overlap between the internal jugular vein and carotid artery in infants?
### Response:
| The CLTIA successfully reduced the overlap between the IJV and the CA in infants. However, further study should be needed to evaluate the clinical usefulness of the CLTIA during the IJV catheterisation. |
### Instruction:
Are acne and PCOS less frequent in women with Mayer-Rokitansky-Küster-Hauser syndrome despite a high rate of hyperandrogenemia : a cross-sectional study?
### Response:
| Although hyperandrogenemia is common, acne is significantly less frequent in women with MRKH than reported in the literature for non-MRKH women, and is seldom treated medically. Patients in this study appeared resistant to acne to some extent, possibly due to the sebaceous glands in the acne regions being less sensitiv... |
### Instruction:
Does low intensity resistance training improve systolic function and cardiovascular autonomic control in diabetic rats?
### Response:
| Low intensity RT induced an increase in systolic function in diabetic rats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabetic rats. |
### Instruction:
Does chaihuang-Yishen granule inhibit diabetic kidney disease in rats through blocking TGF-β/Smad3 signaling?
### Response:
| CHYS may be a therapeutic agent for DN. CHYS attenuates DN by blocking TGF-β/Smad3-mediated renal fibrosis. |
### Instruction:
Is anemia at the initiation of tuberculosis therapy associated with delayed sputum conversion among pulmonary tuberculosis patients in Dar-es-Salaam , Tanzania?
### Response:
| Baseline anemia is associated with increased risk for persistent positive sputum smears at two months of tuberculosis treatment. Future studies should evaluate the mechanisms for TB-associated anemia as well as the role of intervention for anemia among TB patients. |
### Instruction:
Does leptin receptor signaling inhibit ovarian follicle development and egg laying in chicken hens?
### Response:
| Immunization against cLEPR ECD in egg-laying hens generated antibodies that mimic leptin bioactivity by enhancing leptin receptor transduction. This up-regulated apoptotic gene expression in ovarian follicles, negatively regulated the expression of genes that promote follicular development and hormone secretion, leadin... |
### Instruction:
Does muscadine grape skin extract revert snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells?
### Response:
| This study shows that superoxide species may play a role in Snail transcription factor-mediated EMT. Therefore, therapeutic targeting of Snail with various antioxidants such as MSKE may prove beneficial in abrogating EMT and ROS-mediated tumor progression in human prostate cancer. |
### Instruction:
Does pirfenidone attenuate the IL-1β-induced hyaluronic acid increase in orbital fibroblasts from patients with thyroid-associated ophthalmopathy?
### Response:
| Pirfenidone attenuates the IL-1β-induced HA production in orbital fibroblasts from patients with TAO, at least in part, through suppression of the MAPK-mediated HAS expression. These results support the potential use of pirfenidone for treatment of patients with TAO. |
### Instruction:
Does a Notch-dependent transcriptional hierarchy promote mesenchymal transdifferentiation in the cardiac cushion?
### Response:
| We validated 4 of the upstream TFs as Notch targets that are enriched in AVC-EC. Functionally, we show these 4 TFs regulate EMT in AVC explant assays. These novel signaling pathways downstream of Notch are potentially relevant to valve development. |
### Instruction:
Does cholesterol lowering modulate T cell function in vivo and in vitro?
### Response:
| Our results show that lipid lowering reduces T cell proliferation and function, supporting the notion that lipid lowering modulates T cell function in vivo and in vitro. |
### Instruction:
Does social network correlate of participation in telephone continuing care for alcohol dependence?
### Response:
| Participants with more problematic social networks may self-select additional support in the form of telephone continuing care. Telephone continuing care does not appear to result in social network change. |
### Instruction:
Do glomerular filtration rate equations accurately predict vancomycin trough concentrations in pediatric patients?
### Response:
| Neither equation correlates well with vancomycin troughs, suggesting that therapeutic monitoring remains important. Better GFR estimation methods are needed in pediatrics to aid appropriate dosing of renally eliminated medications. |
### Instruction:
Are serum heat shock protein 47 levels elevated in acute interstitial pneumonia?
### Response:
| The present results demonstrate that, among patients with various IIPs, serum levels of HSP47 were elevated specifically in patients with AIP. |
### Instruction:
Is copeptin , a surrogate marker for arginine vasopressin , associated with cardiovascular risk in patients with polycystic ovary syndrome?
### Response:
| Copeptin appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients. |
### Instruction:
Do older patients have the most to gain from orthopaedic enhanced recovery programmes?
### Response:
| This is the first series in the literature to assess the role of enhanced recovery pathways in the very elderly. This study not only shows that successful fast track rehabilitation can be achieved in the very elderly population undergoing elective joint replacement surgery, but that it is this cohort of vulnerable pati... |
### Instruction:
Is serum soluble ST2 associated with ER-positive breast cancer?
### Response:
| Serum sST2 levels in ER-positive breast cancer patients are significantly associated with factors that indicate poor prognosis. |
### Instruction:
Is baseline serum albumin a predictive biomarker for patients with advanced pancreatic cancer treated with bevacizumab : a pooled analysis of 7 prospective trials of gemcitabine-based therapy with or without bevacizumab?
### Response:
| Patients with APCA with normal b-alb derive benefit from treatment with bevacizumab. Future prospective investigations of bevacizumab in patients with APCA should consider selecting patients with normal b-alb to maximize potential benefit. |
### Instruction:
Is heavy domestic , but not recreational , physical activity associated with low back pain : Australian Twin low BACK pain ( AUTBACK ) study?
### Response:
| We found evidence that heavy domestic PA is associated with an increased probability of LBP, and the combination of heavy domestic and recreational PA might increase the probability of LBP more so than heavy domestic or recreational PA alone. Associations being greater when using the co-twin case-control analysis indic... |
### Instruction:
Does tirasemtiv amplify skeletal muscle response to nerve activation in humans?
### Response:
| The data confirm that tirasemtiv amplifies the response of skeletal muscle to nerve input in humans. This outcome provides support for further studies of tirasemtiv as a potential therapy in conditions marked by diminished neuromuscular input. |
### Instruction:
Does donor age negatively affect the immunoregulatory properties of both adipose and bone marrow derived mesenchymal stem cells?
### Response:
| Donor age should be taken into consideration when using recipient MSC of either bone marrow or adipose origin in clinical applications. |
### Instruction:
Is low intraoperative tidal volume ventilation with minimal PEEP associated with increased mortality?
### Response:
| Use of low intraoperative TV with minimal PEEP is associated with an increased risk of 30-day mortality. |
### Instruction:
Does anti-non-Gal-specific combination treatment with an anti-idiotypic Ab and an inhibitory small molecule mitigate the xenoantibody response?
### Response:
| This preliminary study demonstrates the strength of approaches designed to selectively inhibit anti-non-Gal xenoantibody. Both anti-non-Gal-specific anti-idiotypic antibody and small molecules can be used to selectively limit xenoantibody responses. |
### Instruction:
Does gATA-4 transcription factor regulate cardiac COX-2 expression induced by nicorandil in left ventricle of rats?
### Response:
| The present study demonstrated that nicorandil induces COX-2 via GATA-4 induction in the heart through both KATP channel activation and its nitrate-like properties. |
### Instruction:
Are peak hip and knee joint moments during a sit-to-stand movement invariant to the change of seat height within the range of low to normal seat height?
### Response:
| This study concluded that, while the peak mechanical load and the peak hip and knee joint moments increase inversely to seat height within the range of high to normal seat height (60 to 40 cm), they are invariant to the change of seat height within the range of low to normal seat height (10 to 40 cm). These findings ar... |
### Instruction:
Do probiotics in obese pregnancy reduce maternal fasting glucose : a double-blind , placebo-controlled , randomized trial ( Probiotics in Pregnancy Study )?
### Response:
| Probiotic treatment of 4 wk during pregnancy did not influence maternal fasting glucose, the metabolic profile, or pregnancy outcomes in obese women. |
### Instruction:
Is activation of P21-activated protein kinase 2 an independent prognostic predictor for patients with gastric cancer?
### Response:
| Our data suggest for the first time that PAK2 activation may be associated with advanced tumor progression and poor prognosis of gastric cancer. |
### Instruction:
Is neck circumference associated with subclinical atherosclerosis in retired National Football League players?
### Response:
| In retired NFL players with a high prevalence of CAC and CAP, NC was not associated with coronary or carotid subclinical atherosclerosis. NC may not be the most appropriate risk marker for atherosclerosis. |
### Instruction:
Does high expression of DEK predict poor prognosis of gastric adenocarcinoma?
### Response:
| High level of DEK protein expression predicts the poor prognosis of patients with gastric cancer. DEK expression might be potentially used as an independent effective biomarker for prognostic evaluation of gastric cancers. |
### Instruction:
Does microRNA-566 activate EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab?
### Response:
| miR-566 activated EGFR signaling and its inhibition sensitized glioblastoma cells to anti-EGFR therapy. |
### Instruction:
Does dissemination of a simulation-based mastery learning intervention reduce central line-associated bloodstream infections?
### Response:
| This study demonstrates successful dissemination and implementation of a CVC SBML curriculum and shows that rigorous medical education is a powerful quality improvement tool. |
### Instruction:
Does initial use of echinocandins negatively influence outcome in Candida parapsilosis bloodstream infection : a propensity score analysis?
### Response:
| The initial use of an echinocandin-based regimen does not seem to negatively influence outcome in C. parapsilosis BSI. |
### Instruction:
Is increased expression of Capn4 associated with the malignancy of human glioma?
### Response:
| The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. |
### Instruction:
Do beta-blockers increase the risk of being born small for gestational age or of being institutionalised during infancy?
### Response:
| For infants born to mothers with chronic hypertension, compared with those treated by methyldopa alone, those treated by beta-blockers appear to be at increased rates of SGA and hospitalisation during infancy. |
### Instruction:
Do paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences?
### Response:
| Small clinical differences were found between paediatric coeliac patients carrying HLA-DR7-DQ2 and HLA-DR3-DQ2. For a correct screening of HLA-DQ2, at least in our geographical population, the HLA-DR7-DQ2 haplotype should be typed due to its frequency and clinical presentation. |
### Instruction:
Are pneumococcal polysaccharide vaccine responses impaired in a subgroup of children with cystic fibrosis?
### Response:
| Impaired antibody responses to immunization with Pneumovax II are common in children with CF and this may be associated with increased disease severity. |
### Instruction:
Is [ Santa Claus perceived as reliable and friendly : results of the Danish Christmas 2013 survey ]?
### Response:
| The positive associations attributed to Santa Claus probably cause that he is perceived friendlier than the doctor who may be associated with more serious and unpleasant memories of illness and suffering. Surprisingly, and despite him being an imaginary person, Santa Claus was assessed as being as reliable as the docto... |
### Instruction:
Does seven day insertion rest in whole body vibration improve multi-level bone quality in tail suspension rats?
### Response:
| Low-magnitude, high-frequency vibration with rest days altered bone microarchitecture and macro-biomechanical properties, and VL7R was more efficacious in improving bone loss caused by mechanical disuse, which provided theoretical basis and explored the mechanisms of vibration for improving bone quality in clinics. |
### Instruction:
Are complement C1q and C2 polymorphisms risk factors for SLE in Indian Tamils?
### Response:
| The C/T polymorphism in exon 2 of C1qA and a 28bp deletion in sixth exon of C2 gene were found to be rare in south Indian Tamil SLE patients. They do not appear to be susceptibility factors for SLE in Indian Tamils. |
### Instruction:
Is plasma-parathyroid hormone associated with subclinical and clinical atherosclerotic disease in 2 community-based cohorts?
### Response:
| In 2 independent community-based cohorts, PTH was associated to the degree of atherosclerosis and risk of clinically overt atherosclerotic disease, respectively. Our data confirm and extend previous studies supporting a role for PTH in the development of atherosclerotic disease. |
### Instruction:
Does zerumbone inhibit angiogenesis by blocking NF-κB activity in pancreatic cancer?
### Response:
| Zerumbone blocked the PaCa-associated angiogenesis through the inhibition of NF-κB and NF-κB-dependent proangiogenic gene products. |
### Instruction:
Is elevated expression level of microRNA-196a predictive of intestinal-type intraductal papillary mucinous neoplasm of the pancreas?
### Response:
| Elevated expression of miR-196a in pancreatic juice samples is predictive of intestinal-type IPMNs. |
### Instruction:
Does epigallocatechin gallate with photodynamic therapy enhance anti-tumor effects in vivo and in vitro?
### Response:
| It is suggested that high anti-cancer activity of combined photodynamic therapy with EGCG may be useful for effective cancer therapy. |
### Instruction:
Is a GC polymorphism associated with serum 25-hydroxyvitamin D level a risk factor for hip fracture in Japanese patients with rheumatoid arthritis : 10-year follow-up of the Institute of Rheumatology , Rheumatoid Arthritis cohort study?
### Response:
| A two-staged analysis demonstrated that rs2282679 in GC was associated with serum 25(OH)D concentration and could be a risk factor for hip fracture in Japanese RA patients. |
### Instruction:
Does re-trafficking of hERG reverse long QT syndrome 2 phenotype in human iPS-derived cardiomyocytes?
### Response:
| Our in vitro study shows an alternative approach to rescue diseased LQTS2 phenotype via corrective re-trafficking therapy using a small chemical molecule, such as ALLN. This potentially novel approach may have ramifications in other clinically relevant trafficking disorders. |
### Instruction:
Do the role of growth factor Sadat-Habdan mesenchymal stimulating peptide in healing of burn wounds?
### Response:
| Sadat-Habdan mesenchymal stimulating peptide has potential of early healing of experimentally produced burns in rats. Healing was effective and better in the study group compared with the control group, in qualitative and quantitative measures. |
### Instruction:
Is mitigation of carbon tetrachloride-induced hepatic injury by methylene blue , a repurposed drug , mediated by dual inhibition of GSK3β downstream of PKA?
### Response:
| MB has antioxidant and mitochondria-protecting effects and protects the liver from toxicants, which results from the dual inhibition of GSK3β by AMPK downstream of PKA-activated LKB1, and PKA itself. Our findings reveal a novel pharmacological effect of MB and its molecular basis. |
### Instruction:
Are hIV-1 DNA levels in peripheral blood mononuclear cells and cannabis use associated with intermittent HIV shedding in semen of men who have sex with men on successful antiretroviral regimens?
### Response:
| We show that HIV-RNA can be detected intermittently in semen of HIV-1 infected MSM despite successful cART. The size of blood HIV-1 reservoir predicted spVL detection. Our results indicated also that the possible effect of cannabis should be taken into account when developing prevention interventions targeted toward HI... |
### Instruction:
Are many diabetic total joint arthroplasty candidates unable to achieve a preoperative hemoglobin A1c goal of 7 % or less?
### Response:
| When establishing a goal designed to reduce perioperative risks, there should be an expectation that the goal is achievable. Overall, an HbA1c of ≤7.0% was achieved by 380 of the 404 diabetic patients (94%; 95% confidence interval [CI], 91% to 96%), but it was achieved by only thirty-five (59%; 95% CI, 46% to 72%) of t... |
### Instruction:
Does evaluation of Medicare claim data to ascertain peripheral vascular events in the Women 's Health Initiative?
### Response:
| Medicare data appear useful for identifying vascular treatment procedures for WHI participants. Medicare hospital claims identify more procedures than WHI does, with high positive predictive value, but also may not capture some procedures identified in WHI. |
### Instruction:
Is nLR predictive of upstaging at the time of radical cystectomy for patients with urothelial carcinoma of the bladder?
### Response:
| Preoperative NLR is a simple measurement that can be used to identify high-risk patients who may be upstaged at the time of RC and may benefit from neoadjuvant chemotherapy. |
### Instruction:
Are chromosome 9p deletions an independent predictor of tumor progression following nephrectomy in patients with localized clear cell renal cell carcinoma?
### Response:
| Chromosome 9p deletions independently establish a poorer prognosis for patients with localized ccRCC, providing further relevant clinical information that may improve the predictive ability of the main prognostic systems currently in use. |
### Instruction:
Does salusin-β in rostral ventrolateral medulla increase sympathetic outflow and blood pressure via superoxide anions in hypertensive rats?
### Response:
| Salusin-β in the RVLM increases sympathetic outflow, blood pressure and heart rate via NAD(P)H oxidase-derived superoxide anions in renovascular hypertensive rats. |
### Instruction:
Does androgen receptor expression show distinctive significance in ER positive and negative breast cancers?
### Response:
| AR expression was different in ER+ and ER- cancers and had different clinical implications. AR alone may not be a good marker for MA subtype. Its expression in MA may have substantial prognostic implication and as such warrants further validation. |
### Instruction:
Does chronic environmental exposure to lead affect semen quality in a Mexican men population?
### Response:
| These results suggest that chronic environmental exposure to low levels of lead adversely affect the spermatic quality. |
### Instruction:
Is satisfaction with electronic health records associated with job satisfaction among primary care physicians?
### Response:
| We found that EHR satisfaction was associated with job satisfaction in a cross-sectional survey of PCPs. Our conclusions are limited by suboptimum survey response rate, but if confirmed may have substantial implications for how EHR vendors develop their product to support the needs of PCPs. |
### Instruction:
Do improved immunoblotting methods provide critical insights into phenotypic differences between two murine dysferlinopathy models?
### Response:
| ER stress might underlie phenotypic differences between A/J and B10.SJL mice and play a role in human dysferlinopathies. |
### Instruction:
Is caMKKβ-dependent activation of AMP-activated protein kinase critical to suppressive effects of hydrogen sulfide on neuroinflammation?
### Response:
| CaMKKβ-dependent AMPK activation is an unrecognized mechanism underlying H2S suppression on neuroinflammation. |
### Instruction:
Are ventricular arrhythmias a short-term reproducible phenomenon -- why long recording monitoring is necessary?
### Response:
| PVCs, ventricular couplets and NSVT are not a random phenomenon. Our data suggest the occurrence of ventricular arrhythmias had no similarity among the days, making unlikely that a single Holter recording for 24h may capture this phenomenon. |
### Instruction:
Does small Molecule-BIO accelerate and Enhances Marrow-Derived Mesenchymal Stem Cell in Vitro Chondrogenesis?
### Response:
| Taken together, BIO at 0.01 µM could accelerate and enhance in vitro chondrogenesis of mouse marrow-derived MSCs. |
### Instruction:
Do the circular F-actin bundles provide a track for turnaround and bidirectional movement of mitochondria in Arabidopsis root hair?
### Response:
| Relevant experimental results demonstrated that the circular F-actin bundles provide a track for the turnaround and bidirectional movement of mitochondria. |
### Instruction:
Is neutrophilic asthma characterised by increased rhinosinusitis with sleep disturbance and GERD?
### Response:
| The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma. |
### Instruction:
Does creatine supplementation post-exercise enhance training-induced adaptations in middle to older aged males?
### Response:
| Post-exercise ingestion of creatine monohydrate does not provide greater enhancement of body composition and muscle strength compared to resistance training alone in middle to older males. |
### Instruction:
Is nighttime breastfeeding behavior associated with more nocturnal sleep among first-time mothers at one month postpartum?
### Response:
| Women who breastfed exclusively averaged 30 minutes more nocturnal sleep than women who used formula at night, but measures of sleep fragmentation did not differ. New mothers should be encouraged to breastfeed exclusively since breastfeeding may promote sleep during postpartum recovery. Further research is needed to be... |
### Instruction:
Is cardio-respiratory fitness independently associated with cardio-metabolic risk markers in severely obese women?
### Response:
| Our data for the first time indicate that cardio-respiratory fitness is independently associated with cardio-metabolic risk markers in severely obese women. |
### Instruction:
Does daidzein suppress pro-inflammatory chemokine Cxcl2 transcription in TNF-α-stimulated murine lung epithelial cells via depressing PARP-1 activity?
### Response:
| The anti-inflammatory action of daidzein in murine lung epithelial cells seems to be mediated via a direct interaction with PARP-1, which inhibits RelA/p65 protein PARylation required for the transcriptional modulation of pro-inflammatory chemokines such as Cxcl2. |
### Instruction:
Does ginsenoside Rg1 protect mouse podocytes from aldosterone-induced injury in vitro?
### Response:
| Aldosterone enhances ROS generation and promotes autophagy in podocytes in vitro. Ginsenoside-Rg1 effectively relieves aldosterone-induced oxidative stress, thereby indirectly inhibiting aldosterone-induced podocyte autophagy. |
### Instruction:
Does sFlt-1 elevate blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice?
### Response:
| VEGF inhibition augments the pressor response to ET-1. The cyclooxygenase-thromboxane signaling route downstream of ET-1 might be a possible target to prevent BP elevation during VEGF inhibition. |
### Instruction:
Does extrarenal atherosclerotic disease blunt renal recovery in patients with renovascular hypertension?
### Response:
| CAD in patients with ARVD is a predictor of worse outcomes after renal revascularization, likely reflecting diffuse atherosclerotic disease. Further studies are needed to develop strategies to manage patients with vascular comorbidities and improve their outcomes. |
### Instruction:
Is preoperative use of incretins associated with increased diabetes remission after RYGB surgery among patients taking insulin : a retrospective cohort analysis?
### Response:
| Preoperative use of antidiabetic medication, coupled with an incretin agonist, could significantly improve the odds of T2D remission after RYGB surgery in patients also using insulin. |
### Instruction:
Do sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction?
### Response:
| We have described and identified low-frequency rhythmic modulations of repolarization that are associated with sympathetic activity. Increased PRD can be used as a predictor of mortality in survivors of acute MI and patients undergoing exercise testing. |
### Instruction:
Do task-related changes in sensorimotor integration influence the common synaptic input to motor neurones?
### Response:
| Alteration of visual feedback influences nearly the entire frequency spectrum of common input to motor neurones, as well the gain of afferent feedback. We speculate that task-related modulation of afferent feedback could be the origin of many of the observed changes in the neural drive to muscles. |
### Instruction:
Are isolated insular strokes and plasma MR-proANP levels associated with newly diagnosed atrial fibrillation : a pilot study?
### Response:
| Isolated insular strokes and plasma MR-proANP levels on admission are independent predictors of NDAF and significantly improve the prediction accuracy of identifying patients with NDAF compared to known predictors including age, the NIHSS and lesion size. To accelerate accurate diagnosis and enhance secondary preventio... |
### Instruction:
Does an integrative modeling framework reveal plasticity of TGF-β signaling?
### Response:
| As applied here to TGF-β signaling, CADBIOM allows, for the first time, a full integration of highly complex signaling pathways into dynamic models that permit to explore cell responses to complex microenvironment stimuli. |
### Instruction:
Are billions of basepairs of recently expanded , repetitive sequences eliminated from the somatic genome during copepod development?
### Response:
| Our results suggest that germline genome expansion in M. edax reflects explosive repeat element proliferation, and that billions of base pairs of such repeats are deleted from the somatic genome every generation. Thus, we hypothesize that chromatin diminution is a mechanism that controls repeat element load, and that t... |
### Instruction:
Does mucositis not neutropenia determine bacteremia among hematopoietic stem cell transplant recipients?
### Response:
| This study suggests that severe intestinal mucositis, i.e., citrullinemia <10 μmol/L, defines the period of risk of bacteremia better than does neutropenia, and that measuring plasma citrulline may prove useful in deciding who needs empirical antimicrobial therapy and when. |
### Instruction:
Is rosiglitazone a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices?
### Response:
| This study demonstrates the superior effectiveness of RGZ in comparison to CQ and β-adrenoceptor agonists as a dilator of mouse small airways. Further investigation of the mechanisms underlying the relatively greater efficacy of RGZ under these conditions are warranted and should be extended to include studies in human... |
### Instruction:
Are visual hallucinations associated with hyperconnectivity between the amygdala and visual cortex in people with a diagnosis of schizophrenia?
### Response:
| VH-SZ have hyperconnectivity between subcortical areas subserving emotion and cortical areas subserving higher order visual processing, providing biological support for distressing VH in schizophrenia. |
### Instruction:
Does amylase level in drain after pancreatoduodenectomy as a predictor of clinically significant pancreatic fistula?
### Response:
| Patients with CS-PF have higher values of ALD than patients who developed a mild/transient fistula. An ALD higher than 2820 U/L identifies patients likely to present a CS-PF. |
### Instruction:
Do increased intratumoral interleukin 22 levels and frequencies of interleukin 22-producing CD4+ T cells correlate with pancreatic cancer progression?
### Response:
| Increased intratumoral IL-22 levels, IL-22CD4 T cells, and TH22 cells are correlated with PC tumor-node-metastasis staging, suggesting that IL-22 and IL-22CD4 T cells may be related to tumor progression and are potential therapeutic targets in patients with PC. |
### Instruction:
Does activation of glucagon-like peptide-1 receptor inhibit tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway?
### Response:
| GLP-1R activation has an antitumour effect on human pancreatic cancers via inhibition of the PI3K/Akt pathway. This finding suggests that GLP-1-based therapies may be beneficial, rather than harmful, in treating type 2 diabetic patients with pancreatic cancer. |
### Instruction:
Is genetic polymorphism rs6922269 in the MTHFD1L gene associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients?
### Response:
| MTHFD1L rs6922269 genotype is associated with active vitamin B12 levels at baseline and may be a marker of prognostic risk in patients with established coronary heart disease. |
### Instruction:
Are glucose impairment and ghrelin gene variants associated to cognitive dysfunction?
### Response:
| Glucose impairment and L90G Ghrelin gene variant influence cognitive function in old dwelling individuals participating in the Mataró Ageing Study. |
### Instruction:
Do alzheimer disease cerebrospinal fluid biomarkers predict cognitive decline in healthy elderly over 2 years?
### Response:
| CSF-BMK-AD are able to discriminate between subjects in a group initially asymptomatic depending on their cognitive evolution at the 2 years' follow-up. These results are consistent with the decrease of CSF Aβ1-42 protein levels as the first finding in preclinical AD showed. |
### Instruction:
Does systematic review and meta-analysis of wound drain after thyroid surgery?
### Response:
| The results indicate that drain use after routine thyroid surgery does not confer a benefit to patients. |
### Instruction:
Does angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induce liver fibrosis?
### Response:
| Our study substantiates the important cell-intrinsic role of JAK2 in HSCs for development of liver fibrosis. Inhibition of JAK2 might therefore offer a promising therapy for liver fibrosis. |
### Instruction:
Does age of first arrest vary by gambling status in a cohort of young adults?
### Response:
| Problem gambling was significantly associated with earlier age of being arrested. Dilution effects after adjustment for several deviant behaviors and illegal drug use by age 17 suggest that youth exposure to certain common factors may result in engagement in multiple risky behaviors, including problem gambling. Studies... |
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