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### Instruction:
Is free glycogen in vaginal fluids associated with Lactobacillus colonization and low vaginal pH?
### Response:
| These findings show that free glycogen in genital fluid is associated with a genital microbiota dominated by Lactobacillus, suggesting glycogen is important for maintaining genital health. Treatments aimed at increasing genital free glycogen might impact Lactobacillus colonization. |
### Instruction:
Does microRNA-182 modulate chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4?
### Response:
| The results of the present study demonstrated that overexpression of miR-182 may involve in chemoresistance of NSCLC cells to cisplatin by down-regulating PDCD4. |
### Instruction:
Does soy protein and genistein improve renal antioxidant status in experimental nephrotic syndrome?
### Response:
| It seems that soy protein decreases kidney damages in nephrotic syndrome. Adding genistein to soy protein causes improvements in antioxidant status of kidney tissue. Genistein decreases proliferation of cell. |
### Instruction:
Does darbepoetin-α accelerate neovascularization and engraftment of extrahepatic colorectal metastases?
### Response:
| The present study indicates that DPO accelerates extrahepatic engraftment of colorectal cancer cells, most probably by stimulating the process of neovascularization. |
### Instruction:
Is optimization of novel spectral estimator for fractionated electrogram analysis helpful to discern atrial fibrillation type?
### Response:
| NSE optimization produces greater spectral parameter difference between persistent versus paroxysmal AF data. Quantifying spectral parameter differences can be assistive in characterizing the arrhythmogenic substrate. |
### Instruction:
Does substance P mediate reduced pneumonia rates after traumatic brain injury?
### Response:
| The data demonstrate that patients with traumatic brain injury have lower rates of pneumonia compared to non-head-injured trauma patients and suggest that the mechanism of this effect occurs through traumatic brain injury-induced release of substance P, which improves innate immunity to decrease pneumonia. |
### Instruction:
Is aLK expression absent in pancreatic ductal adenocarcinoma?
### Response:
| In 99 PDAC cases, no ALK expression was detected by IHC; ALK thus may not serve as a relevant drug target in PDAC. |
### Instruction:
Does comparative genome sequencing reveal chemotype-specific gene clusters in the toxigenic black mold Stachybotrys?
### Response:
| The results suggest that chemotype-specific gene clusters are likely the genetic basis for the mutually-exclusive toxin chemotypes of Stachybotrys. A unified biochemical model for Stachybotrys toxin production is presented. Overall, the four genomes described here will be useful for ongoing studies of this mold's diver... |
### Instruction:
Is multi-constituent synergism responsible for anti-inflammatory effect of Azadirachta indica leaf extract?
### Response:
| Anti-inflammatory effect of A. indica is a result of cumulative and synergistic effects of diversified constituents with varying polarities that collectively exert the effect via suppression of cyclo-oxygenases and cytokines (IL-1 and TNF-α). |
### Instruction:
Does mammalian target of rapamycin cell signaling pathway contribute to the protective effects of ischemic postconditioning against stroke?
### Response:
| mTOR plays a crucial protective role in brain damage after stroke and contributes to the protective effects of IPC. |
### Instruction:
Does absence of γ-sarcoglycan alter the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle?
### Response:
| p70S6K is an important component of γ-sarcoglycan-dependent mechanotransduction in skeletal muscle. Our results suggest that loss of γ-sarcoglycan uncouples the response of p70S6K to stretch and implies that γ-sarcoglycan is important for inactivation of this pathway. Overall, we assert that altered load-sensing mechan... |
### Instruction:
Does time-averaged albumin predict the long-term prognosis of IgA nephropathy patients who achieved remission?
### Response:
| The strong predictive relationship of low TA-ALB and high TA-SCr levels with progression observed in this study suggests that TA-ALB may serve as a marker of the long-term renal prognosis of IgAN patients who have achieved remission. |
### Instruction:
Is coexistence of perineural invasion and lymph node metastases a poor prognostic factor in patients with locally advanced rectal cancer after preoperative chemoradiotherapy followed by radical resection and adjuvant chemotherapy?
### Response:
| The presence of either PNI or ypN was a significant prognostic factor for predicting poor survival rates in LARC patients, especially those with a coexistence of both factors. Accordingly, we recommend an intensive follow-up and therapeutic programs for LARC patients with simultaneous PNI+ and ypN+. |
### Instruction:
Is renal hyperfiltration associated with glucose-dependent changes in fractional excretion of sodium in patients with uncomplicated type 1 diabetes?
### Response:
| Patients with uncomplicated T1D-H exhibit lower FENa under euglycemic conditions, which may help to identify patients with hyperfiltration outside of a controlled laboratory setting. Increased FENa in T1D-H but not T1D-N under clamped hyperglycemic conditions suggests that the mechanisms responsible for increased sodiu... |
### Instruction:
Do cultures of diabetic foot ulcers without clinical signs of infection predict outcomes?
### Response:
| Culturing DFUs that showed no clinical signs of infection had no predictive value for outcomes of DFUs managed with total-contact casts and routine debridement. These findings support recommendations of the Infectious Disease Society of America that culturing and antibiotics should be avoided in treating DFUs that show... |
### Instruction:
Does the alpha subunit of Go modulate cell proliferation and differentiation through interactions with Necdin?
### Response:
| These results collectively suggest that Necdin is a candidate downstream effector for Gαo. Our findings provide novel insights into the cellular roles of Gαo and its coupled receptor. |
### Instruction:
Does metformin suppress lipid accumulation in skeletal muscle by promoting fatty acid oxidation?
### Response:
| Metformin retards body weight gain, improves insulin sensitivity, and suppresses lipid accumulation in skeletal muscle by promoting fatty acid oxidation. |
### Instruction:
Are serum magnesium , phosphorus , and calcium associated with risk of incident heart failure : the Atherosclerosis Risk in Communities ( ARIC ) Study?
### Response:
| Low serum magnesium and high serum phosphorus and calcium were independently associated with greater risk of incident HF in this population-based cohort. Whether these biomarkers will be useful candidates for HF risk prediction or targets for prevention remains to be seen. |
### Instruction:
Do moderate amounts of fructose- or glucose-sweetened beverages do not differentially alter metabolic health in male and female adolescents?
### Response:
| Moderate amounts of HF- or HG-sweetened beverages for 2 wk did not have differential effects on fasting or postprandial cholesterol, triacylglycerol, glucose, or hepatic insulin clearance in weight-stable, physically active adolescents. |
### Instruction:
Is the allergenic structure of the thaumatin-like protein Ole e 13 degraded by processing of raw olive fruits?
### Response:
| IgE-reactive TLP is not present in edible olive, thus explaining the low number of patients allergic to this highly consumed fruit. Patients allergic to olive pollen are not sensitized toTLP and, therefore, not expected to be at risk of food allergy to olive fruit or TLP plant sources. |
### Instruction:
Does e/A ratio before cardiac resynchronization therapy predict left ventricle reverse remodeling?
### Response:
| Our experience confirms that about 2 out of 3 patients are responder to CRT and their clinical improvements remain stable in a long term follow-up. Patients with a less severe E/A ratio are more likely to improve their clinical condition as shown by the reverse remodeling measured through the LVEDD. |
### Instruction:
Does association between dentures and the rate of fall in dementia?
### Response:
| It was concluded that age, non-Malay ethnicity, functional decline, heart disease, and oral health significantly affected falls in dementia. |
### Instruction:
Do endoscopists with low adenoma detection rates benefit from high-definition endoscopy?
### Response:
| The use of HD scopes is associated with marginal improvement in adenoma detection rates limited to those endoscopists with low adenoma detection rates prior to its introduction. |
### Instruction:
Does iLM peeling technique influence the degree of a dissociated optic nerve fibre layer appearance after macular hole surgery?
### Response:
| ILM peeling technique and possibly other surgeon-specific factors appear to influence the extent of DONFL observed after ILM peeling macular hole surgery. |
### Instruction:
Does the thyroid-related quality of life measure ThyPRO have good responsiveness and ability to detect relevant treatment effects?
### Response:
| The ThyPRO was responsive to treatment across the range of benign thyroid diseases. We suggest implementing this measurement instrument as a patient-reported outcome in clinical studies and in clinical management. |
### Instruction:
Does genome and transcriptome sequencing identify breeding targets in the orphan crop tef ( Eragrostis tef )?
### Response:
| It is highly plausible that breeding targets previously identified in other cereal crops will also be valuable breeding targets in tef. The draft genome and transcriptome will be of great use for identifying these targets for genetic improvement of this orphan crop that is vital for feeding 50 million people in the Hor... |
### Instruction:
Do cofilin rods and aggregates concur with tau pathology and the development of Alzheimer 's disease?
### Response:
| Cofilin rods and aggregates signify events initiated early in the pathological cascade. Further definition of the mechanisms leading to their formation in the human brain will provide insights into the cellular causes of AD. |
### Instruction:
Do neurotrauma burden in a tropical urban conurbation level I trauma centre?
### Response:
| Neurotrauma is one of the most common form of trauma at our surgical emergency. Assault and road traffic injury (RTI) were the most common cause of TBI and TSI respectively, with RTI being the most common cause of moderate and severe TBI. The incidence and aetiology of TBI varies according to age and gender. |
### Instruction:
Does percutaneous screw fixation promote healing of lateral condyle nonunion in children?
### Response:
| We demonstrate this technique to be successful in nonunions addressed within 16 weeks from initial injury to diagnosis. Our 4 failures occurred in nonunions diagnosed >31 weeks from the injury (31, 68, 383, 427 wk). All had been managed nonoperatively as their primary treatment plan.Percutaneous fixation is feasible an... |
### Instruction:
Does low cardiac output stimulate vasopressin release in patients with stage d heart failure?
### Response:
| Low cardiac output stimulates AVP release via a non-osmotic process that results in hyponatremia and poor prognosis in patients with stage D HF. After sufficient recovery of cardiac output by cardiac replacement therapy, AVP release is suppressed and is mainly regulated by serum osmolality. |
### Instruction:
Does parenting stress predict depressive symptoms in adolescents with inflammatory bowel disease?
### Response:
| Parenting stress impacts adolescent depressive symptoms in IBD. Identification of parenting stress and adolescent depression should occur early and possibly in the context of routine clinic visits. |
### Instruction:
Is extracellular matrix biomarker , fibulin-1 , closely related to NT-proBNP and soluble urokinase plasminogen activator receptor in patients with aortic valve stenosis ( the SEAS study )?
### Response:
| Increased levels of fibulin-1 were independently associated with higher levels of suPAR and NT-proBNP especially in patients with lower AVAI, suggesting that fibulin-1 may be an early marker of AS as well as cardiac fibrosis secondarily to elevated left ventricular hemodynamic load. |
### Instruction:
Does waddlia chondrophila infect and multiplies in ovine trophoblast cells stimulating an inflammatory immune response?
### Response:
| W. chondrophila infects and grows in the ruminant trophoblast AH-1 cell line exhibiting a complete chlamydial replicative cycle. Infection of the trophoblasts resulted in the expression of pro-inflammatory cytokines in a dose-dependent manner similar to that observed with C. abortus in previous studies, suggesting simi... |
### Instruction:
Does caveolin-1 modulate cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase?
### Response:
| The present studies reveal the critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias. These data provide a mechanistic explanation for the observed genetic link between Cav1 and cardiac arrhythmias in humans and suggest that targeted regulation of Cav1 may reduce arrh... |
### Instruction:
Does cOUP-TFII regulate metastasis of colorectal adenocarcinoma cells by modulating Snail1?
### Response:
| Chicken ovalbumin upstream promoter-transcription factor II was crucial for colorectal cancer metastasis and regulated cell migration and metastasis in conjunction with Snail1. Chicken ovalbumin upstream promoter-transcription factor II was found to be a biomarker associated with patient survival and colorectal cancer ... |
### Instruction:
Does meta-analysis in more than 17,900 cases of ischemic stroke reveal a novel association at 12q24.12?
### Response:
| Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage. |
### Instruction:
Is menopause associated with lumbar disc degeneration : a review of 4230 intervertebral discs?
### Response:
| Menopause is associated with disc degeneration in the lumbar spine. The association almost entirely occurred in the first 15 years since menopause, suggesting estrogen decrease may be a risk factor for lumbar disc degeneration. |
### Instruction:
Does one size fit all : psychometric properties of the Shona Symptom Questionnaire ( SSQ ) among adolescents and young adults in Zimbabwe?
### Response:
| Scales were not administered separately or in their entirety but rather overlapping items were only asked once, utilizing exclusively SRQ-20 phrasing rather than the culturally-emic language in the SSQ. |
### Instruction:
Does endogenous erythropoietin vary significantly with inflammation-related proteins in extremely premature newborns?
### Response:
| Our findings suggest that in very preterm newborns, circulating levels of endogenous erythropoietin vary significantly with circulating levels of inflammation-related proteins. Elevation of endogenous erythropoietin might not be an epiphenomenon, but instead might contribute to subsequent events, by either promoting or... |
### Instruction:
Do [ Glybenclamide regulate ERK1/2 signal pathway during hypoxia hypercapnia pulmonary vasoconstriction in rats ]?
### Response:
| Gly may mediate HHPV via activating ERK1/2 signal transduction pathway. |
### Instruction:
Does hMGN2 protein inhibit the growth of infected T24 cells in vitro?
### Response:
| HMGN2 protein could inhibit the growth of infected T24 cells in vitro, and the anti-tumor action of HMGN2 was due to induce apoptosis. |
### Instruction:
Does resveratrol successfully treat experimental endometriosis through modulation of oxidative stress and lipid peroxidation?
### Response:
| In a rat endometriosis model, resveratrol showed potential ameliorative effects on endometriotic implants probably due to its potent antioxidative properties. |
### Instruction:
Does genetic variance in ABCB1 and CYP3A5 contribute toward the development of chronic kidney disease after liver transplantation?
### Response:
| An individual's risk of developing CKD after LT is not associated with genetic variation in either recipient or donor CYP3A5 or ABCB1 genotype status. |
### Instruction:
Does combination of microtubule associated protein-tau and β-tubulin III predict chemosensitivity of paclitaxel in patients with advanced gastric cancer?
### Response:
| The combination of MAP-tau and TUBB3 was found to predict chemosensitivity to paclitaxel in gastric cancer in vitro and in vivo. This merits further study and may help guide individual therapy. |
### Instruction:
Is [ Acoustic radiation force impulse imaging elastography efficacious in detecting hepatic fibrosis in children ]?
### Response:
| The speed of shear wave propagation is significantly associated with the degree of hepatic fibrosis in children. |
### Instruction:
Do beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity?
### Response:
| This study generally provided evidence of profound anti-inflammatory activity of β-amyrin and α-amyrin acetate isolated from the Alstonia boonei stem bark. |
### Instruction:
Are adverse conditions at the workplace associated with increased suicide risk?
### Response:
| A negative working environment concerning chronobiological or physical conditions at the workplace had an unfavourable impact on suicide mortality risk, even after controlling for relevant suicide-related risk factors. Employer interventions aimed to improve workplace conditions might be considered as a suitable means ... |
### Instruction:
Does methanol extract from Vietnamese Caesalpinia sappan induce apoptosis in HeLa cells?
### Response:
| This study is the first report of the anticancer properties of the heartwood of C. sappan native to Vietnam. Our findings demonstrate that C. sappan heartwood may have beneficial applications in the field of anticancer drug discovery. |
### Instruction:
Are circulating concentrations of the novel adipokine chemerin associated with cardiovascular disease risk in rheumatoid arthritis?
### Response:
| Chemerin is associated with endothelial activation and atherosclerosis in RA. Adiposity influences the chemerin-atherosclerotic phenotype relations in RA. |
### Instruction:
Does indication alert intercept drug name confusion errors during computerized entry of medication orders?
### Response:
| Indication alerts intercepted 1.4 drug name confusion errors per 1000 alerts. Institutions with CPOE should consider using indication prompts to intercept drug name confusion errors. |
### Instruction:
Is glycaemia associated with cognitive impairment in older adults : the Guangzhou Biobank Cohort Study?
### Response:
| an FBG level indicative of T2DM was associated with increased risk for cognitive impairment. The findings also demonstrate that glycaemia is continuously associated with cognitive impairment, suggesting that dysfunction is associated with increasing glucose levels even in the normoglycaemic range. |
### Instruction:
Do self-assembling nanofibers alter the processing of amyloid precursor protein in a transgenic mouse model of Alzheimer 's disease?
### Response:
| Our data suggest that IKVAV-PA may serve as an alternative therapeutic intervention for treating the learning and memory losses in AD. |
### Instruction:
Do systemically available bone morphogenetic protein two and seven affect bone metabolism?
### Response:
| Surprisingly, both BMP-2 and -7 showed an increased bone volume in an in vivo environment of low calciotropic hormones. Locally administered BMP-2 and -7 from bone devices might become partially available in circulation but will not mediate systemic bone loss. |
### Instruction:
Is baseline hypovitaminosis D associated with poor clinical outcomes in osteoarticular infections?
### Response:
| To our knowledge this is the first report on hypovitaminosis D and its impact on outcomes of osteoarticular infections. Hypovitaminosis D was frequent in this cohort. With vitamin D repletion, there was no difference in treatment success whether patients had baseline hypovitaminosis or not. |
### Instruction:
Is coronary microvascular dysfunction related to abnormalities in myocardial structure and function in cardiac amyloidosis?
### Response:
| Coronary microvascular dysfunction is highly prevalent in subjects with cardiac amyloidosis, even in the absence of epicardial CAD, and may explain their anginal symptoms. Further study is required to understand whether specific therapy directed at amyloidosis may improve coronary vasomotion in amyloidosis. |
### Instruction:
Does thiamin supplementation reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos?
### Response:
| Thiamin supplementation reduced biochemical thiamin deficiency among Lao malaria patients following anti-malarial drug treatment, but it did not reduce the frequency of adverse events after anti-malarial therapy or have any detected clinical or parasitological impact. |
### Instruction:
Does novel loss-of-function PRRT2 mutation cause paroxysmal kinesigenic dyskinesia in a Han Chinese family?
### Response:
| Our findings demonstrated that the c.186-187delGC mutation resulted in a truncated protein from the PRRT2 gene to involve in PKD pathogenesis with haploinsufficiency. The results extend the mutation spectrum of the PRRT2 gene and provide a new example for studying the pathogenesis of the mutated PRRT2 gene. |
### Instruction:
Does targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improve its therapeutic potency?
### Response:
| Targeted delivery of anti-inflammatory cytokines potentiates their anti-arthritic action in a mouse model of arthritis. Our results further support the hypothesis that targeting biotherapeutics to arthritic joints may be extended to include anti-inflammatory cytokines that lack efficacy when administered systemically. |
### Instruction:
Is interleukin-17 a favorable prognostic marker for colorectal cancer?
### Response:
| The association between IL-17 expression and the clinicopathological parameters, as well as the clinical outcome suggests a significant role of IL-17 in CRC. IL-17 is a marker of favorable prognosis. |
### Instruction:
Is aortic valve sclerosis associated with lower serum adiponectin levels?
### Response:
| In patients with aortic sclerosis, serum adiponectin levels were significantly lower compared with those with normal aortic valves. Our findings suggested that adiponectin might play a role in the progression of degenerative aortic valve disease. |
### Instruction:
Does conventional surgery result in patients originally referred for transcatheter aortic valve implantation?
### Response:
| AVR should be indicated with caution in high-risk patients originally referred for TAVI. Despite medium-term results being good, with excellent functional status, hospital mortality is not negligible. |
### Instruction:
Is the homeobox gene EMX2 a prognostic and predictive marker in malignant pleural mesothelioma?
### Response:
| EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival. |
### Instruction:
Does single level lumbar laminectomy alter segmental biomechanical behavior without affecting adjacent segments?
### Response:
| The increase in range of motion of 7-12% does not seem to indicate the use of additional instrumentation to stabilize the lumbar spine. If instrumentation is still considered in a patient, its primary focus should be on re-stabilizing only the treated segment level. |
### Instruction:
Is broca 's area damage necessary but not sufficient to induce after-effects of cathodal tDCS on the unaffected hemisphere in post-stroke aphasia?
### Response:
| Behavioral effects of cathodal tDCS on the unaffected right hemisphere differ depending on whether BA and the arcuate fasciculus are damaged. Therefore, IH imbalance could be a direct consequence of anatomical lesions. |
### Instruction:
Does dietary fatty acid content regulate wound repair and the pathogenesis of osteoarthritis following joint injury?
### Response:
| Our results indicate that with obesity, dietary FA content regulates wound healing and OA severity following joint injury, independent of body weight, supporting the need for further studies of dietary FA supplements as a potential therapeutic approach for OA. |
### Instruction:
Does nADPH oxidase hyperactivity induce plantaris atrophy in heart failure rats?
### Response:
| Our data provide evidence for NADPH oxidase hyperactivation as an important source of ROS production leading to plantaris atrophy in heart failure rats, suggesting that this enzyme complex plays key role in skeletal muscle wasting in HF. |
### Instruction:
Does 25-Hydroxyvitamin D in African-origin populations at varying latitudes challenge the construct of a physiologic norm?
### Response:
| It is widely assumed that lighter skin color in populations outside the tropics resulted from positive selection, driven in part by the relation between sun exposure, skin melanin content, and 25(OH)D production. Our findings show that robust compensatory mechanisms exist that create tolerance for wide variation in cir... |
### Instruction:
Does preoperative neutrophil-lymphocyte ratio predict death among patients with localized clear cell renal carcinoma undergoing nephrectomy?
### Response:
| Our results suggest that NLR is independently associated with increased risks of cancer-specific and all-cause mortality among patients with M0 ccRCC undergoing RN. Accordingly, NLR, an easily obtained marker of biologically aggressive ccRCC, may be useful in preoperative patient risk stratification. |
### Instruction:
Does simulated microgravity affect chondrogenesis and hypertrophy of human mesenchymal stem cells?
### Response:
| SMG reduced hypertrophy of hMSCs during chondrogenic differentiation. However, the expression of COL2A1 was likewise reduced. Even more, the COL2A1/COL10A1 ratio decreased under SMG conditions. We therefore assume that SMG has a significant impact on the chondrogenic differentiation of hMSCs. However, due to the high C... |
### Instruction:
Is the number of 131I therapy courses needed to achieve complete remission an indicator of prognosis in patients with differentiated thyroid carcinoma?
### Response:
| If more than one RIT course is needed to achieve CR, higher recurrence and DTC-related mortality rates are observed, especially in high-risk patients. Patients requiring >22.2 GBq (131)I for CR should be followed in the same way as patients in whom CR is never reached as long-term mortality rates are similar. |
### Instruction:
Are obsessive compulsive symptoms related to lower quality of life in patients with Schizophrenia?
### Response:
| Questioning of comorbid OCS and treatment with specific medication in schizophrenia patients may increase QoL. |
### Instruction:
Is activation of hypoxia-inducible factor-1α in type 2 alveolar epithelial cell a major driver of acute inflammation following lung contusion?
### Response:
| Activation of hypoxia-inducible factor-1α in type 2 cell is a major driver of acute inflammation following lung contusion. |
### Instruction:
Does [ Calculation of standardised unit cost from a societal perspective for health economic evaluation ]?
### Response:
| The calculated unit costs can serve as a reference case in health economic evaluations and hence help to increase their comparability. |
### Instruction:
Do aDHD inattentive symptoms mediate the relationship between intelligence and academic performance in children aged 6-14?
### Response:
| Fluid intelligence is a relevant factor in the influence of ADHD behavioral symptoms on academic performance, but its impact is indirect. Therefore, early identification of both fluid intelligence and inattentive symptoms is of the utmost importance to prevent impaired academic performance and future difficulties in fu... |
### Instruction:
Is renin-angiotensin system inhibition associated with increased sudden cardiac death , cardiovascular mortality or all-cause mortality in patients with aortic stenosis?
### Response:
| RASI was not associated with SCD, cardiovascular or all-cause mortality in asymptomatic AS patients. However, RASI was associated with a potentially beneficial decrease in blood pressure and reduced LV mass progression. |
### Instruction:
Does baseline HBsAg predict response to pegylated interferon-α2b in HBeAg-positive chronic hepatitis B patients?
### Response:
| Baseline HBsAg level in combination with HBV DNA may become an effective predictor for guiding optimal therapy with PEG-IFN-α2b against HBeAg-positive CHB. |
### Instruction:
Is dNA methyltransferase3a expression an independent poor prognostic indicator in gastric cancer?
### Response:
| The results suggest that expression of DNMT3a is an independent poor prognostic indicator in gastric cancer. DNMT3a might play an important role in gastric carcinogenesis. |
### Instruction:
Does inhibition of Girdin enhance chemosensitivity of colorectal cancer cells to oxaliplatin?
### Response:
| Girdin knockdown enhances chemosensitivity of colorectal cancer cells to oxaliplatin via TOP2B down-regulation. These findings provide a promising approach to overcome the chemoresistance of colorectal cancer cells. |
### Instruction:
Are neutropenia and relative dose intensity on adjuvant FOLFOX chemotherapy associated with survival for resected colon cancer?
### Response:
| DLTs affect the majority of patients on adjuvant FOLFOX for high-risk colon cancer, but RFS and OS do not appear to be affected by the associated lower RDI of oxaliplatin and 5-FU. |
### Instruction:
Do plasma proteins predict conversion to dementia from prodromal disease?
### Response:
| We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints. |
### Instruction:
Is sudden cardiac death associated both with epilepsy and with use of antiepileptic medications?
### Response:
| Epilepsy and AEM use are both associated with increased SCD risk in the general population. Poor seizure control contributes to increased SCD risk in epilepsy, while sodium channel blockade contributes to SCD susceptibility in AEM users. |
### Instruction:
Does pioglitazone treatment reduce adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity?
### Response:
| The PPARγ agonist pioglitazone increased adipocyte size yet improved other features of adipose, increasing capillary number and reducing mast cells and inflammatory macrophages. The increase in elastin may better permit adipocyte expansion without triggering cell necrosis and an inflammatory reaction. |
### Instruction:
Is optic nerve sheath diameter on computed tomography correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury?
### Response:
| Simultaneous measurement of ONSD on CT and ICP were strongly correlated and ONSD was discriminative for intracranial hypertension. ONSD was much more predictive of ICP than other CT features. There was excellent agreement between raters in measuring ONSD. |
### Instruction:
Does loss of HuR lead to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB?
### Response:
| In the absence of HuR, cells exhibit multiple senescence-associated phenotypes. Our findings suggest that HuR regulates not only the replicative lifespan, but also the expression of SASP-related cytokines in mouse fibroblasts. |
### Instruction:
Does defunctioning polymorphism in the immunoglobulin G inhibitory receptor ( FcγRIIB-T/T232 ) impact on kidney transplant or recipient survival?
### Response:
| This negative result is surprising, given the importance of this receptor in modulating antibody effector function. |
### Instruction:
Is cytoplasmic expression of SSTR2 and 5 by immunohistochemistry and by RT/PCR associated with the pharmacological response to octreotide?
### Response:
| Expression of these receptors does not guarantee an adequate response to somatostatin analogs; other functional aspects of this interaction, such as receptor homo- and heterodimerization, and the resulting signaling cascade, probably play a role in determining whether a patient will respond or not to these agents. |
### Instruction:
Is cOPD exacerbation severity and frequency associated with impaired macrophage efferocytosis of eosinophils?
### Response:
| Macrophage efferocytosis of eosinophils is impaired in COPD and is related to the severity and frequency of COPD exacerbations. |
### Instruction:
Is the presence of tumor-infiltrating IL-17-producing cells in juvenile nasopharyngeal angiofibroma tumor microenvironment a poor prognostic factor?
### Response:
| In JNA patients, a high level of IL-17-producing cells was negatively associated with patient's age. Patients with extensive infiltration of IL-17-producing cells had significantly higher tumor recurrence rates. High infiltration of IL-17-producing cells in JNA microenvironment is an independent poor prognostic factor ... |
### Instruction:
Do trypanosoma cruzi strains cause different myocarditis patterns in infected mice?
### Response:
| This study supports parasite variability as a cause for the diverse cardiac outcomes observed in Chagas disease, and suggests that endothelial cells could be involved in heart infection during the acute phase. |
### Instruction:
Do responses to the McGill Pain Questionnaire predict neuropathic pain medication use in women in with vulvar lichen sclerosus?
### Response:
| Vulvar pain is a common presenting symptom in women with LS. Responses to the McGill Pain Questionnaire may be helpful in the long-term management of women with LS as a screen to identify those patients who might benefit from adjunctive neuropathic pain medication use. |
### Instruction:
Is the D allele of angiotensin-converting enzyme gene associated with greater hemodynamic response to resistance exercises?
### Response:
| ACE DD carriers exhibit greater heart work during resistance exercise. Future studies should focus on the influence of resistance training period with different workloads on the hemodynamic response in healthy individuals with different ACE genotypes. |
### Instruction:
Does a common haplotype of KIAA0319 contribute to the phonological awareness skill in Chinese children?
### Response:
| In conclusion, our findings suggest that KIAA0319 is associated with a reading-related cognitive skill. |
### Instruction:
Does recombinant Human Keratinocyte Growth Factor induce Akt Mediated Cell Survival Progression in Emphysematous Mice?
### Response:
| Histopathology photomicrographs and destructive index analysis have shown that elastase-induced airspace enlargement and loss of alveoli recovered in the treatment group. rHuKGF stimulates VEGF production which in turn induces the Akt mediated cell survival pathway in emphysematous lungs. mRNA expression of VEGF, VEGFR... |
### Instruction:
Does lipopolysaccharide exposure during pregnancy lead to aortic dysfunction in offspring rats?
### Response:
| Decreased expression of Cx37 contributed to the aortic dysfunction of prenatal LPS exposure offspring, which should be associated with NF-κB activation. |
### Instruction:
Do perioperative antibiotics covering bile contamination prevent abdominal infectious complications after pancreatoduodenectomy in patients with preoperative biliary drainage?
### Response:
| A perioperative antibiotic strategy particular to PBD procedures is valid for covering biliary microorganisms during pancreatoduodenectomy. Perioperative antibiotics covering bile contamination may prevent abdominal infectious complications after pancreatoduodenectomy in patients with and without PBD. |
### Instruction:
Do mannose-binding lectin and ficolin-2 influence humoral immune response to hepatitis B vaccine?
### Response:
| Our study does not support a prominent role of the lectin pathway of complement in general and MBL and FCN2 in particular in the humoral immune response to HBV vaccination in African adults. |
### Instruction:
Does diversion remain the standard of care for modern management of war-related rectal injuries?
### Response:
| Diversion is the preferred treatment of war-related rectal injuries. Loop colostomy is acceptable unless there is potential for evolving rectal injury. Routine use of presacral irrigation and drainage was not supported. |
### Instruction:
Does egr-1 regulate the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter?
### Response:
| These results demonstrate that Egr-1 regulates NGX6 gene transcription through an overlapping Sp1/Egr-1 binding site as a positive regulator of NGX6 gene. |
### Instruction:
Are increased levels of interleukin-6 in tracheal aspirate fluid indicative of fetal inflammation in ventilated extremely low gestational age newborns?
### Response:
| Elevated TAF IL-6 levels at birth are strongly associated with funisitis. The TAF IL-6 concentration is a useful marker for detecting fetal inflammation in ventilated ELGAN. |
### Instruction:
Does a mouse model of otitis media identify HB-EGF as a mediator of inflammation-induced mucosal proliferation?
### Response:
| Our data suggest an active role for HB-EGF in the hyperplasia of the middle ear mucosal epithelium during otitis media. These results imply that therapies targeting HB-EGF could ameliorate mucosal growth during otitis media, and thereby reduce detrimental sequelae of this childhood disease. |
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