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### Instruction:
Do cD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to Minnelide?
### Response:
| As Minnelide is currently under phase I clinical trial, its evaluation in reducing tumor burden by decreasing TIC as well as non-TIC population suggests its potential as an effective therapy. |
### Instruction:
Are pacific and Atlantic Lepeophtheirus salmonis ( Krøyer , 1838 ) allopatric subspecies : Lepeophtheirus salmonis salmonis and L. salmonis oncorhynchi subspecies novo?
### Response:
| Lepeophtheirus salmonis from the Pacific and Atlantic oceans are reproductively compatible at least until adults at the F2 hybrid stage, and should not be regarded as separate species based on reproductive segregation or sequence divergence levels. Reported biological and genetic differences in L. salmonis seen in conj... |
### Instruction:
Does circulating miR-18a in plasma contribute to cancer detection and monitoring in patients with gastric cancer?
### Response:
| Circulating miR-18a could be a useful biomarker for screening GC and monitoring tumor dynamics. |
### Instruction:
Is higher plasma vitamin D associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases?
### Response:
| Higher plasma calcifediol [25(OH)D] is associated with reduced risk of C. difficile infection in patients with IBD. Further studies of therapeutic supplementation of vitamin D in patients with inflammatory bowel disease and C. difficile infection may be warranted. |
### Instruction:
Do protective behavioral strategies mediate problem-focused coping and alcohol use in college students?
### Response:
| This is the first study to find that protective behavioral strategies are more likely to be used by college students who endorse using a problem-focused coping style, especially if they tend to use behaviorally oriented problem-focused coping strategies. These findings extend the literature on protective behavioral str... |
### Instruction:
Is plasma S100A12 associated with functional outcome after ischemic stroke : Research for Biomarkers in Ischemic Stroke?
### Response:
| High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke. |
### Instruction:
Is hIF-1α and GLUT1 gene expression associated with chemoresistance of acute myeloid leukemia?
### Response:
| Our data revealed that over-expression of HIF-1α and GLUT1 might play a role in the chemoresistance of AML. GLUT1 might be a potential target to reverse such drug resistance. |
### Instruction:
Does echocardiography predict major adverse cardiovascular events after renal transplantation?
### Response:
| Preoperative transthoracic echocardiography identifies patients at risk of death or non-fatal cardiovascular events even late after renal transplantation. This suggests that echocardiography might be useful to identify patients requiring more aggressive long-term treatment of modifiable vascular risk factors. |
### Instruction:
Does voltage-gated sodium channel expression in mouse DRG after SNI lead to re-evaluation of projections of injured fibers?
### Response:
| The complex regulation of Na(v)s, together with the anatomical rostral shift of the DRG harboring injured fibers in C57BL/6 J mice, emphasize that caution is necessary and preliminary anatomical experiments should be carried out for gene and protein expression studies after SNI in mouse strains. |
### Instruction:
Does a Pro23His mutation alter prenatal rod photoreceptor morphology in a transgenic swine model of retinitis pigmentosa?
### Response:
| Prenatal expression of mutant rhodopsin alters the normal morphological and functional development of rod photoreceptors in TgP23H swine embryos. Despite this significant change, cone photoreceptors are unaffected. Human infants with similarly aggressive RP might never have rod vision, although cone vision would be una... |
### Instruction:
Is epistasis between polymorphisms in PCSK1 and DBH associated with premature ovarian failure?
### Response:
| Epistases between SNPs within PCSK1 and DBH genes are significantly associated with susceptibility or resistance to POF. |
### Instruction:
Does barringtonia acutangula improve the biochemical parameters in diabetic rats?
### Response:
| These results suggest that the leaf aqueous and ethanolic extracts of B. acutangula have anti-diabetic effects. The aqueous extract of B. acutangula produced a similar effect when compared with the ethanol extract. It is proposed that consumption of B. acutangula in some form like tea may help the management of diabete... |
### Instruction:
Does absence of the gut microbiota enhance anxiety-like behavior and neuroendocrine response to acute stress in rats?
### Response:
| In stress-sensitive F344 rats, absence of the gut microbiota exacerbates the neuroendocrine and behavioral responses to acute stress and the results coexist with alterations of the dopaminergic turnover rate in brain upper structures that are known to regulate reactivity to stress and anxiety-like behavior. |
### Instruction:
Does low socioeconomic status negatively affect sleep in pregnant women?
### Response:
| Low SES was associated with poorer sleep quality and fragmented sleep, even after statistical adjustments. Perceived stress and financial strain attenuated SES-sleep associations indicating that psychosocial situations preceding pregnancy are also important to consider. |
### Instruction:
Do rock outcrop orchids reveal the genetic connectivity and diversity of inselbergs of northeastern Brazil?
### Response:
| The comparative approach adopted in this study contributed to the elucidation of patterns in both species. Our results confirm the ancient and highly isolated nature of inselberg populations. Both species showed similar patterns of genetic diversity and structure, highlighting the importance of seed-restricted gene flo... |
### Instruction:
Does overexpression of BAT3 alleviate prion protein fragment PrP106-126-induced neuronal apoptosis?
### Response:
| Our present data showed a novel molecular mechanism of PrP106-126-induced apoptotic process regulation through the overexpression of BAT3, which may be important for the basic regulatory mechanism of neuron survival in prion diseases and associated neurodegenerative diseases in vivo. |
### Instruction:
Is the association between leptin and depressive symptoms modulated by abdominal adiposity?
### Response:
| The present findings suggest that low leptin signaling rather than low leptin concentration is a risk factor for depression. Future studies should develop proxy measures of leptin signaling by combining information on abdominal adiposity and leptin level to be used for clinical and research applications. |
### Instruction:
Does outpatient pain predict subsequent one-year acute health care utilization among adults with sickle cell disease?
### Response:
| Findings support use of outpatient CPI scores or pain intensity and age to identify at-risk young adults with SCD who are likely to benefit from improved outpatient pain management plans. |
### Instruction:
Are sarcomere gene mutations associated with increased cardiovascular events in left ventricular hypertrophy : results from multicenter registration in Japan?
### Response:
| These results demonstrate that HCM with sarcomere gene mutations can be associated with increased cardiovascular events compared with HHD or HCM without sarcomere gene mutations. |
### Instruction:
Is secretion of prohormone of B-type natriuretic peptide , proBNP1-108 , increased in heart failure?
### Response:
| ProBNP(1-108) is secreted by nonfailing and failing human hearts, but more so in the latter. It remains to be established where peripheral processing of proBNP(1-108) occurs and how this is affected by disease. |
### Instruction:
Does subthalamic nuclear tissue contrast in inversion recovery MRI decrease with age in medically refractory Parkinson 's disease?
### Response:
| STN, a common stimulation target, shows an age dependent trend for normalized FSTIR MRI contrast. Although larger patient pools are needed, our work points to tissue relaxation-based changes in STN that may provide insight in early stages of brain pathology involving DBS targets in medically refractory Parkinson's dise... |
### Instruction:
Is multiple sclerosis associated with high trait anger : a case-control study?
### Response:
| The present study provides further evidence that MS is independently associated with high trait anger. |
### Instruction:
Does prevalence and correlate of HIV and hepatitis B virus coinfection in Northern Alberta?
### Response:
| The prevalence of coinfection with HBV in HIV-infected patients in Northern Alberta is lower than reported in other developed nations. The pattern of coinfections in Northern Alberta likely follows immigration trends. Recognition and management may be improving with time; however, further research and additional strate... |
### Instruction:
Does patterns and correlate of cannabis use among individuals with HIV/AIDS in Maritime Canada?
### Response:
| Prolonged previous cannabis consumption and the substantial overlap between recreational and medicinal cannabis use highlight the challenges in obtaining a tenable definition of medicinal cannabis therapy. |
### Instruction:
Does systematic assessment of prognostic gene signatures for breast cancer show distinct influence of time and ER status?
### Response:
| Generally, these signatures performed better for ER-positive disease, indicating that risk within each ER stratum is driven by distinct underlying biology. Most of the signatures were strong risk predictors for DMFS during the first 5 years of follow-up. Combining gene signatures with histological grade or tumor size, ... |
### Instruction:
Does iKVAV regulate ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation?
### Response:
| Our results demonstrated that IKVAV stimulated BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways. This study is the first to reveal an enhancement effect of IKVAV peptide on BMMSC at the signal transduction level, and the outcome could provide experimental evidence for... |
### Instruction:
Are iL10 single nucleotide polymorphisms related to upregulation of constitutive IL-10 production and susceptibility to Helicobacter pylori infection?
### Response:
| Our results indicate that IL10 variants rs1800896, rs3024491, rs1878672, and rs3024496 are more consistently associated with the presence of anti-H. pylori IgG by inducing increased production of IL-10. Further studies are underway to elucidate the role of additional genetic variants and to investigate their impact on ... |
### Instruction:
Is baseline staging tests based on molecular subtype necessary for newly diagnosed breast cancer?
### Response:
| These data indicate that based on clinical staging and molecular subtypes, BS, LUS and CXR are necessary for patients with newly diagnosed breast cancer. |
### Instruction:
Are modifiable clinical and lifestyle factors associated with elevated alanine aminotransferase levels in newly diagnosed type 2 diabetes patients : results from the nationwide DD2 study?
### Response:
| Among newly diagnosed T2DM patients, several modifiable clinical and lifestyle factors are independent markers of elevated ALT levels. |
### Instruction:
Is the extent of inflammation a predictor for pouch-related complications in ileal pouches in patients with ulcerative or indeterminate colitis?
### Response:
| The extension of inflammation into the muscularis propria appears to predict pouch-related complications following restorative proctocolectomy for UC or IC. |
### Instruction:
Does expression of a constitutively active prolactin receptor cause histone trimethylation of the p53 gene in breast cancer?
### Response:
| Delta S2 PRLR plays an important pathogenic role in breast cancer through epigenetic modification. Elevated expression of Delta S2 PRLR, achieved by alternate splicing of the pre-mRNA of the full-length form, is a new mechanism contributing to human breast cancer. |
### Instruction:
Does postablation neutrophil/lymphocyte ratio correlate with arrhythmia recurrence after catheter ablation of lone atrial fibrillation?
### Response:
| Our results indicate that an elevated post-NLR is associated with a high rate of lone AF recurrence. A simple measurement of NLR may help us to identify high-risk patients who need pharmacologic intervention to prevent recurrence. |
### Instruction:
Does helicobacter pylori vacA d1 genotype predict risk of gastric adenocarcinoma and peptic ulcers in northwestern Iran?
### Response:
| This study suggests that the H pylori vacA d1 genotype helps predict risk for gastric adenocarcinoma and PUD in East Azerbaijan, Iran. |
### Instruction:
Does verbal memory decline more rapidly with age in HIV infected versus uninfected adults?
### Response:
| This is the first longitudinal study focused on the effects of age and HIV on memory. Findings suggest that age and HIV interact to produce larger declines in verbal memory over time. Further research is needed to gain a greater understanding of the effects of HIV on the aging brain. |
### Instruction:
Does monocyte chemoattractant protein-1 ( MCP-1 ) regulate macrophage cytotoxicity in abdominal aortic aneurysm?
### Response:
| Our data suggest that MCP-1-primed macrophages are more cytotoxic. MCP-1 appears to modulate macrophage cytotoxicity by increasing the level of membrane bound FasL. Thus, we showed that MCP-1-primed macrophages kill SMCs through a FasL/Fas-Caspase8-RIP1 mediated mechanism. |
### Instruction:
Is ganglioside disialosyl globopentaosylceramide an independent predictor of PSA recurrence-free survival following radical prostatectomy?
### Response:
| 5F3 expression reflects the clinical and pathological features of prostate cancer and is correlated with the outcomes following RP. Further studies are necessary to clarify the functional roles of DSGb5 and establish a novel biomarker for prostate cancer. |
### Instruction:
Are corticosteroids associated with repression of adaptive immunity gene programs in pediatric septic shock?
### Response:
| Administration of corticosteroids in pediatric septic shock is associated with additional repression of genes corresponding to adaptive immunity. These data should be taken into account when considering the benefit to risk ratio of adjunctive corticosteroids for septic shock. |
### Instruction:
Does expression of a fungal ferulic acid esterase in alfalfa modify cell wall digestibility?
### Response:
| Modifying cell wall crosslinking has the potential to lower recalcitrance of holocellulose, but also exhibited unintended consequences on alfalfa cell wall digestibility due to elevated lignin content. The combination of efficient delignification treatment (alkaline peroxide) and transgenic esterase activity complement... |
### Instruction:
Do intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock?
### Response:
| These results indicate that gut and gut-induced lung injury after T/HS involves a complex process consisting of intraluminal digestive enzymes, the unstirred mucus layer, and a systemic ischemic-reperfusion injury. This suggests the possibility of intraluminal therapeutic strategies. |
### Instruction:
Is a prospective observational study of abdominal injury management in contemporary military operations : damage control laparotomy associated with high survivability and low rates of fecal diversion?
### Response:
| Damage control is now used routinely for battlefield abdominal trauma. In a well-practiced Combat Support Hospital, this strategy is associated with low mortality and infrequent fecal diversion. |
### Instruction:
Do israeli psychiatrists report on their ability to care for individuals with intellectual disability and psychiatric disorders?
### Response:
| Results point to an urgent need to increase the level of knowledge and skills of psychiatrists and improve the level of services offered to people with intellectual disabilities and mental health problems. Various options for achieving this are presented. |
### Instruction:
Is a higher serum alkaline phosphatase associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan?
### Response:
| In this large cohort study, higher serum ALP levels were independently associated not only with mortality but also with the incidence of hip fracture in Japanese HD patients. Further study is needed to test whether serum ALP measurements could improve the patient outcomes. |
### Instruction:
Is the Insertion/Deletion Polymorphism of Angiotensin I Converting Enzyme Gene Associated With Ossification of the Posterior Longitudinal Ligament in the Korean Population?
### Response:
| These results suggest that the deletion polymorphism of the ACE gene may be a risk factor for the development of OPLL in the Korean population. |
### Instruction:
Do early corrosion-related failure of the rejuvenate modular total hip replacement?
### Response:
| The short-term high rate of corrosion-related revision with Rejuvenate modular-neck stems is striking. |
### Instruction:
Does fretting and corrosion in modular-neck total hip arthroplasty femoral stem?
### Response:
| The ABG II dual modular hip system is associated with a high rate of early failure secondary to fretting and corrosion at the femoral neck-stem taper. The component has subsequently been recalled and is no longer in use. Surgeons using modular hip systems with a titanium stem and cobalt-chromium neck should be vigilant... |
### Instruction:
Do changes in mipomersen dosing regimen provide similar exposure with improved tolerability in randomized placebo-controlled study of healthy volunteers?
### Response:
| This study demonstrated a similar drug exposure and overall safety profile between the 3 dosing regimens. Exploratory assessment of a diverse panel of biomarkers found no indication of a systemic inflammatory response to mipomersen treatment. These results support assessment of alternative dose regimens in longer-term ... |
### Instruction:
Do presymptomatic electrophysiological tests predict clinical onset and survival in SOD1 ( G93A ) ALS mice?
### Response:
| Electrophysiological tests predict clinical disease onset, survival, and spinal motoneuron preservation in SOD1(G93A) mice. This is a methodological improvement for preclinical studies. |
### Instruction:
Does kugel patch method prevent the development of a femoral hernia after inguinal herniorrhaphy?
### Response:
| The results of this study suggested the importance of repairing all hernia orifices when repairing a groin hernia. The Kugel patch repair method is available for all inguinal region hernias by the same approach, and it seems to be useful for preventing the development of recurrence after surgery. |
### Instruction:
Does sex modify the APOE-related risk of developing Alzheimer disease?
### Response:
| APOE4 confers greater AD risk in women. Biomarker results suggest that increased APOE-related risk in women may be associated with tau pathology. These findings have important clinical implications and suggest novel research approaches into AD pathogenesis. |
### Instruction:
Do cigarettes with different nicotine levels affect sensory perception and levels of biomarkers of exposure in adult smokers?
### Response:
| These studies demonstrate that abrupt increases or decreases in nicotine and the resulting sensory changes impact BOE through changes in intensity or frequency of smoking. |
### Instruction:
Is maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma associated with increased autocrine of IGF1?
### Response:
| Maintenance of stemness in oxaliplatin-resistant hepatocellular carcinoma cells is associated with increased autocrine of IGF1. |
### Instruction:
Do plant lignans inhibit growth and trichothecene biosynthesis in Fusarium graminearum?
### Response:
| Knowledge of the regulation of trichothecene production in Fusarium graminearum by environmental cues is key to the design of novel strategies to reduce mycotoxin levels in grains. Here, we show that the lignans pinoresinol and secoisolariciresinol, which occur in wheat grains, inhibit radial growth and decrease tricho... |
### Instruction:
Is the active form of MMP-3 a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases?
### Response:
| We have successfully developed an assay measuring act-MMP-3 in human serum showing correlation to inflammatory markers. Further studies are required to clarify, whether act-MMP-3 can serve as a predictive marker for outcome in chronic rheumatoid disorders. |
### Instruction:
Do prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation?
### Response:
| Our findings indicate that oncogenic ETS rearrangements cause a cell migration gene expression program to switch from RAS/ERK control to PI3K/AKT control and provide a possible explanation for the high frequency of PTEN, but not RAS/RAF mutations in prostate cancer. |
### Instruction:
Does recurrence season impact the survival of epithelial ovarian cancer patients?
### Response:
| The recurrence season impacts the survival of epithelial ovarian cancer patients. However, the diagnosed season does not appear to exert a significant influence. |
### Instruction:
Does thyroid `` atypia of undetermined significance '' with nuclear atypia have high rates of malignancy and BRAF mutation?
### Response:
| The AUS-NA subcategory was associated with the highest risk of malignancy and the greatest frequency of BRAF V600E (substitution of valine to glutamic acid at position 600) mutation. These findings suggest that subcategorization of AUS by cytomorphology and BRAF V600E mutation status is important for predicting the ris... |
### Instruction:
Does indomethacin prophylaxis for heterotopic ossification after acetabular fracture surgery increase the risk for nonunion of the posterior wall?
### Response:
| Treatment with 6 weeks of indomethacin does not appear to have a therapeutic effect for decreasing HO formation after acetabular fracture surgery and appears to increase the incidence of nonunion. Treatment with 1 week of indomethacin may be beneficial for decreasing the volume of HO formation without increasing the in... |
### Instruction:
Do early gestational weight gains within current recommendations result in increased risk of gestational diabetes mellitus among Korean women?
### Response:
| This study suggests that both target weight gain and energy intake recommendations for early pregnancy may not be optimal for Korean women and that race-specific recommendations are needed to decrease the risk of GDM without increasing adverse pregnancy outcomes. |
### Instruction:
Is choline kinase beta required for normal endochondral bone formation?
### Response:
| Chkb has a critical role in the normal embryogenic formation of the radius and ulna in mice. |
### Instruction:
Is suboptimal care and metabolic acidemia associated with neonatal encephalopathy but not with neonatal seizures alone : a population-based clinical audit?
### Response:
| Suboptimal care was commonly seen with NE, particularly in neonates with metabolic acidemia, and also affected neonatal outcome. No such associations were found in neonates with seizures alone. |
### Instruction:
Do asthma treatment decisions by pediatric residents consistently conform to guidelines or improve with level of training?
### Response:
| Pediatric residents' management of asthma is consistent with national guidelines in some cases but not in others. There were no differences in the outpatient asthma management decisions between residents by years in training. Educational efforts should be focused on strategies to facilitate pediatric resident adherence... |
### Instruction:
Is spatial variability during gait initiation while dual tasking increased in individuals with mild cognitive impairment?
### Response:
| Step length and step width variability is increased in people with MCI during GI, particularly in a condition involving a secondary cognitive task. These findings suggest that individuals with MCI have reduced balance control when undertaking a challenging walking task such as gait initiation, and this is exacerbated w... |
### Instruction:
Does inhibition of HSP70 reduce porcine reproductive and respiratory syndrome virus replication in vitro?
### Response:
| Our study revealed that HSP70 is an essential host factor required for the replication of PRRSV. The inhibition of HSP70 significantly reduced PRRSV replication, which may be applied as an effective antiviral strategy. |
### Instruction:
Do fine mapping of locus Xq25.1-27-2 for a low caries experience phenotype?
### Response:
| Our study failed to conclusively demonstrate that genetic factors in Xq25.1-27-2 contribute to caries experience in multiple populations. |
### Instruction:
Does β-adrenergic signaling inhibit Gq-dependent protein kinase D activation by preventing protein kinase D translocation?
### Response:
| β-AR signaling triggers local nuclear signaling and inhibits GqR-mediated PKD activation by preventing its intracellular translocation. PKA-dependent phosphorylation of PKD-S427 fine-tunes the PKD responsiveness to GqR-agonists, serving as a key integration point for β-adrenergic and Gq-coupled stimuli. |
### Instruction:
Does miR-638 suppress cell proliferation in gastric cancer by targeting Sp2?
### Response:
| Our results demonstrated that miR-638 suppressed GC cell proliferation by targeting Sp2 with influence on the expression of cyclin D1. We suggest that miR-638 might be a candidate predictor or an anticancer therapeutic target for GC patients. |
### Instruction:
Do hypotension in the first week of acute pancreatitis and APACHE II score predict development of infected pancreatic necrosis?
### Response:
| Hypotension in the first week of AP and APACHE II score predict development of IN. |
### Instruction:
Do the titanium PV I endosteal implant from beta-titanium alloy Ti 38Nb 6Ta?
### Response:
| A new anti-rotation PV I implant with microthreads and conical anchorage of the abutment into the fixture was formed. The beta-titanium alloy Ti38Nb6Ta used for the implant was biocompatible and had higher mechanical and physical properties than the existing titanium alloys. The PV I implant was recommended for clinica... |
### Instruction:
Does supraorbital stimulation induce an antidepressant-like response in rats?
### Response:
| Supraorbital stimulation was ineffective in rats undergoing the FST. Such findings do not invalidate results of recent clinical trials. |
### Instruction:
Does product information for parenteral colistin vary substantially across Europe?
### Response:
| This study highlights the challenges of integrating new rapidly evolving scientific knowledge into approved SPCs in Europe. |
### Instruction:
Is sOCS3 promoter hypermethylation a favorable prognosticator and a novel indicator for G-CIMP-positive GBM patients?
### Response:
| Using a total of 359 clinical samples, we demonstrate that SOCS3 promoter hypermethylation status has a favorable prognostic value in GBM patients because of whole genome methylation status. Particularly, the hypermethylation of the SOCS3 promoter indicates positive G-CIMP status. |
### Instruction:
Do the importance of electrically evoked stapedial reflex in cochlear implant?
### Response:
| The electrically elicited stapedius reflex may support when programming the cochlear implant, especially in patients with inconsistent responses. |
### Instruction:
Do s100A9 and EGFR gene signatures predict disease progression in muscle invasive bladder cancer patients after chemotherapy?
### Response:
| The S100A9/EGFR level is a novel prognostic marker to predict the chemoresponsiveness of patients with locally recurrent or metastatic MIBC. |
### Instruction:
Is diabetes-specific quality of life but not health status independently associated with glycaemic control among patients with type 2 diabetes : a cross-sectional analysis of the ADDITION-Europe trial cohort?
### Response:
| Diabetes-specific QoL but not health status was independently associated with HbA1c. Practitioners should take account of the complex relationship between diabetes-specific QoL and glucose, particularly with regard to dietary behaviour. Future research should attempt to elucidate via which pathways this association mig... |
### Instruction:
Is a BRCA1 deficient-like signature enriched in breast cancer brain metastases and predicts DNA damage-induced poly ( ADP-ribose ) polymerase inhibitor sensitivity?
### Response:
| A BD-L signature is enriched in HER2+ breast cancer brain metastases without pathogenic BRCA1 mutations. Unexpectedly, elevated BD-L values are found in a subset of primary tumors across all breast cancer subtypes. Evaluation of pharmacological sensitivity in breast cancer cell lines representing all breast cancer subt... |
### Instruction:
Does activin A induce growth arrest through a SMAD- dependent pathway in hepatic progenitor cells?
### Response:
| Activin A, acting through the SMAD pathway, negatively regulates the proliferation of hepatic progenitor cells. |
### Instruction:
Do perceptual and locomotor factors affect obstacle avoidance in persons with visuospatial neglect?
### Response:
| Persons with VSN are at the risk of colliding with dynamic obstacles approaching from the contralesional side and from head-on. Locomotor-specific assessments of navigational abilities are needed to appreciate the recovery achieved or challenges faced by persons with VSN. |
### Instruction:
Is acute cellular rejection with isolated v-lesions associated with more favorable outcomes than vascular rejection with more tubulointerstitial inflammations?
### Response:
| The extent of TI is non-specifically associated with graft loss in biopsies with AVR; the higher grade v-lesion predicts the lower complete reversal rate and poorer long-term graft survival. |
### Instruction:
Is apoptomiRs expression modulated by BCR-ABL linked to CML progression and imatinib resistance?
### Response:
| This study showed the modulation of apoptomiRs by BCR-ABL kinase activity and the deregulation of apoptomiRs and their predicted apoptotic target genes in different CML phases and after treatment with TK inhibitors. ApoptomiRs may be involved in the BCR-ABL(+) cell apoptosis regulation. |
### Instruction:
Does analysis of automatic match result for cone-beam computed tomography localization of conventionally fractionated lung tumors?
### Response:
| Users of automatic matching techniques should carefully consider how user-defined parameters affect tumor localization. Automatic matches using the PTV as the structure VOI and a small ROI were most consistent with a physician's manual match, and were independent of volumetric tumor changes. |
### Instruction:
Is extended embryo culture associated with increased adverse obstetric or perinatal outcome?
### Response:
| Live births resulting from extended embryo culture and a single blastocyst transfer are not associated with increased adverse obstetric and perinatal outcome compared to live births from a single cleavage embryo transfer in women ≤40 years old. |
### Instruction:
Does preoperative mild-to-moderate coronary artery disease affect long-term outcomes of lung transplantation?
### Response:
| Mod-CAD does not appear to be associated with increased perioperative morbidity or decreased survival after transplant. Coronary artery disease may worsen and require coronary revascularization in patients with risk factors for disease progression. In these patients, close follow-up and screening for progression of cor... |
### Instruction:
Is omitting radiotherapy in early positron emission tomography-negative stage I/II Hodgkin lymphoma associated with an increased risk of early relapse : Clinical results of the preplanned interim analysis of the randomized EORTC/LYSA/FIL H10 trial?
### Response:
| On the basis of this analysis, combined-modality treatment resulted in fewer early progressions in clinical stage I/II HL, although early outcome was excellent in both arms. The final analysis will reveal whether this finding is maintained over time. |
### Instruction:
Is incident stroke associated with common carotid artery diameter and not common carotid artery intima-media thickness?
### Response:
| Although common carotid IMT is not associated with stroke, interadventitial diameter of the common carotid artery is independently associated with first-time incident ischemic stroke even after adjusting for IMT. Our hypothesis that this is in part attributable to the effects of exposure to blood pressure needs confirm... |
### Instruction:
Do nonselective β blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis?
### Response:
| Among patients with cirrhosis and SBP, NSBBs increase the proportion who are hemodynamically compromised, time of hospitalization, and risks for hepatorenal syndrome and acute kidney injury. They also reduce transplant-free survival. Patients with cirrhosis and SBP should not receive NSBBs. |
### Instruction:
Are proactive parents assets to the health and well-being of teens?
### Response:
| PPs are an asset to the health promotion and the well-being of their teens. PPs were more likely to have their teen receive an annual visit, report more frequent discussions about health, and place a high value on physician discussions about health. |
### Instruction:
Does plaque reduction neutralization antibody test accurately predict protection against dengue infection in Ratchaburi cohort , Thailand?
### Response:
| This report provides evidence that PRNT may not be a good test for predicting protection against subsequent dengue infection. |
### Instruction:
Does inhalation but not transdermal resorption of hand sanitizer ethanol cause positive ethyl glucuronide findings in urine?
### Response:
| Ethanol from hand sanitizers is predominantly incorporated by the respiratory tract but not via the skin. It can cause a distinct ethyl glucuronide excretion and thus analytically true-positive but forensically false-positive EtG findings in the urine of ethanol abstaining persons. Since accidental ethanol inhalation c... |
### Instruction:
Is androgenetic alopecia associated with increased arterial stiffness in asymptomatic young adults?
### Response:
| We concluded that, AGA might be an indicator of arterial stiffness in asymptomatic young adults. |
### Instruction:
Is inordinate glucose variation poststroke associated with poor neurological improvement in patients without history of diabetes?
### Response:
| Inordinate glucose variation correlated with less neurological improvement poststroke, giving the evidence that the fluctuation of glucose levels in stroke patients should be taken into consideration during glucose modulation. |
### Instruction:
Does constitutive homologous expression of phosphoglucomutase and transaldolase increase the metabolic flux of Fusarium oxysporum?
### Response:
| Homologous overexpression of phosphoglucomutase and transaldolase in F. oxysporum was shown to enhance the growth characteristics of the strain in both xylose and glucose in aerobic conditions. The intracellular metabolites profile indicated how the changes in the metabolome could have resulted in the observed growth c... |
### Instruction:
Does microRNA-150 be up-regulated in extranodal marginal zone lymphoma of MALT type?
### Response:
| The previously reported up-regulation of miR-150 in marginal zone lymphoma of MALT type was verified in an independent cohort of lymphoma samples employing a modified methodology. This further substantiates the role of miR-150 as a potential oncomiR in MALT lymphoma. |
### Instruction:
Does downregulation of ROCK2 through nanocomplex sensitize the cytotoxic effect of temozolomide in U251 glioma cells?
### Response:
| In conclusion, our results demonstrate that the combination of TMZ and siROCK2 effectively induces apoptosis and inhibits the migration of U251 cells. Therefore, the combination of TMZ and siROCK2 complex is a potential therapeutic approach for human glioma. |
### Instruction:
Is total antioxidant level correlated with intra-ocular pressure in patients with primary angle closure glaucoma?
### Response:
| The inverse correlation of TAS level with IOP, highlights TAS potential role as a predictive-marker for PACG-severity. |
### Instruction:
Is cognitive complexity of the medical record a risk factor for major adverse events?
### Response:
| CCMR correlates with physician assessment of complexity and risk of adverse events. We hypothesize that increased CCMR increases the risk of physician cognitive overload. An automated version of the Complexity Ruler could allow identification of at-risk patients in real time. |
### Instruction:
Does eRβ regulate NSCLC phenotypes by controlling oncogenic RAS signaling?
### Response:
| The ability of ERβ1 to regulate the oncogenic functions of RAS suggests its importance in the biology of NSCLC and its clinical management. Mol Cancer Res; 12(6); 843-54. ©2014 AACR. |
### Instruction:
Is percent Body Fat Measured by Bioelectrical Impedance Associated with Colorectal Adenoma Status?
### Response:
| Percent body fat calculated by BIA was not associated with adenoma prevalence. Although BIA is a quick and convenient measure of adiposity, it is not predictive of adenoma risk perhaps because it measures the amount of fat but not the distribution. |
### Instruction:
Does genome segment 5 of Antheraea mylitta cytoplasmic polyhedrosis virus encode a bona fide guanylyltransferase?
### Response:
| Viral capping enzymes play a critical role in the post transcriptional or post replication modification in case of RNA virus. Our results of cloning, sequencing and functional analysis of AmCPV S5 indicates that S5 encoded p65 through its guanylyltransferase activity can transfer guanine residue to the 5' end of viral ... |
### Instruction:
Do an update on out-of-hospital airway management practices in the United States?
### Response:
| Low out-of-hospital ETI and alternate airway success rates were observed. These data may guide national efforts to improve out-of-hospital airway management quality leading efforts to better educate providers on ETI. |
### Instruction:
Does a novel HIV-1-encoded microRNA enhance its viral replication by targeting the TATA box region?
### Response:
| We have identified a novel HIV-1-encoded miRNA which specifically enhances viral production and provide a specific method to activate HIV-1 latency. |
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