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### Instruction:
Do components of the dorsal-ventral pathway also contribute to anterior-posterior patterning in honeybee embryos ( Apis mellifera )?
### Response:
| We found that early acting pathways (Toll and Dpp) are involved not only in DV patterning but also AP patterning in honeybee embryogenesis. Changes to the expression patterns and function of these genes may reflect evolutionary changes in the placement of the extra-embryonic membranes during embryogenesis with respect ... |
### Instruction:
Are patients with epilepsy at an increased risk of subsequent stroke : a population-based cohort study?
### Response:
| The patients with epilepsy exhibited a higher incidence of cerebral stroke than the general population did. In addition, younger patients with epilepsy and patients who took a high doses of antiepileptic drugs exhibited a high risk of stroke. |
### Instruction:
Do human melanoma metastases demonstrate nonstochastic site-specific antigen heterogeneity that correlates with T-cell infiltration?
### Response:
| Site-specific antigen heterogeneity represents a novel attribute for human melanoma metastases that should be considered in future therapy development and when assessing the responsiveness to antigen-specific immunotherapies. |
### Instruction:
Do anti-VEGF antibodies mitigate the development of radiation necrosis in mouse brain?
### Response:
| The single-hemispheric irradiation mouse model, with longitudinal MRI monitoring, provides a powerful platform for studying the onset and progression of radiation necrosis and for developing and testing new therapies. The observation that anti-VEGF antibodies are effective mitigants of necrosis in our mouse model will ... |
### Instruction:
Is miR-141 a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression?
### Response:
| miR-141 serves as a potential biomarker for discriminating ccRCC from normal tissues and a crucial suppressor of ccRCC cell proliferation and metastasis by modulating the EphA2/p-FAK/p-AKT/MMPs signaling cascade. |
### Instruction:
Does appendicitis-the balance between cost effectiveness and safety remain challenging?
### Response:
| CT can be effectively applied for the diagnosis of acute appendicitis. We propose a diagnostic algorithm which helps to simultaneously avoid unnecessary operations and radiation exposure. |
### Instruction:
Do ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium?
### Response:
| Ly-6C(high) monocytes orchestrate both inflammatory and reparative phases during myocardial infarction and depend on Nr4a1 to limit their influx and inflammatory cytokine expression. |
### Instruction:
Does neoadjuvant chemotherapy improve survival of patients with upper tract urothelial carcinoma?
### Response:
| Neoadjuvant chemotherapy improved the survival of patients with UTUC compared with a matched historic cohort of patients who underwent initial surgery. Patients with high-risk UTUC should be considered for neoadjuvant chemotherapy in view of the limited opportunity to administer effective cisplatin-based chemotherapy a... |
### Instruction:
Is impaired coronary flow reserve the most important marker of viable myocardium in the myocardial segment-based analysis of dual-isotope gated myocardial perfusion single-photon emission computed tomography?
### Response:
| Stress/rest reversibility (impaired CFR) during dual-isotope gated myocardial perfusion SPECT was the single most important predictor of wall motion improvement after CABG. |
### Instruction:
Is metabolic syndrome associated with poor treatment response to antiviral therapy in chronic hepatitis C genotype 3 patients?
### Response:
| Metabolic syndrome has an influence on therapeutic outcomes in terms of SVR. Moreover, this information can identify patients who might have a low chance of attaining an SVR and a timely decision may protect the patients from the adverse effects of therapy. |
### Instruction:
Does plasma Epstein-Barr viral DNA load at midpoint of radiotherapy course predict outcome in advanced-stage nasopharyngeal carcinoma?
### Response:
| Unfavorable EBV DNA response at midcourse of RT/CRT is an adverse prognosticator for treatment outcome, is linked to majority of all failures, and discriminates outcome better than tumor stage. The data could provide a basis for trial design that addresses alteration of therapy intensity during the latter phase of CRT,... |
### Instruction:
Do changes in contractile and elastic properties of the triceps surae muscle induced by neuromuscular electrical stimulation training?
### Response:
| These changes in contractile and elastic properties may lead to functional changes of particular interest in sport-related activities as well as in the elderly. |
### Instruction:
Does unsuspected serious abdominal trauma after fall among community-dwelling older adults?
### Response:
| Falls in elderly patients are exceedingly common mandating recognition of even rare complications. Physicians should be more aware of the possibility of occult and serious consequences of blunt abdominal trauma after falls among older adults, albeit rare. |
### Instruction:
Does cC chemokine receptor 6 expression predict poor prognosis in hepatocellular carcinoma?
### Response:
| CCR6 could be used as a molecular marker to predict prognosis for HCC. J. Surg. Oncol. 2014; 110:151-155. © 2014 Wiley Periodicals, Inc. |
### Instruction:
Does estrogen deficiency reduce the expression of estrogen receptor-beta in Wistar rats ` periodontal tissues?
### Response:
| Estrogen deficiency resulted in a significant decrease in the expression of ER-beta in both tibia and periodontal tissues. |
### Instruction:
Does survival rate of Astra Tech implant with maxillary sinus lift?
### Response:
| Astra Tech implants placed in the maxillary molar region had generally good survival rates, but the relationship between reduced pre-implant alveolar bone height and implant failure requires further attention. |
### Instruction:
Are women diagnosed with type 2 diabetes at higher body mass indices and older ages than men : Korea national health and nutrition examination survey 2007-2010?
### Response:
| Korean adult women are diagnosed with type 2 diabetes at higher BMI and older age than men and are more insulin-resistant at the time of diabetes diagnosis. This may help explain why women with diabetes have an increased risk of developing cardiovascular disease after the diagnosis of diabetes, compared to men. |
### Instruction:
Does sulforaphane inhibit the proliferation of the BIU87 bladder cancer cell line via IGFBP-3 elevation?
### Response:
| Sulforaphane could suppress the proliferation of BIU87 cells via enhancing IGFBP-3 expression, which negatively regulating the NF-κB signaling pathway. |
### Instruction:
Does hOXB7 predict poor clinical outcome in patients with advanced esophageal squamous cell cancer?
### Response:
| HOXB7 predicts poor prognosis of advanced ESCC patients and can be applied as an independent prognostic predictor. |
### Instruction:
Is left ventricular diastolic dysfunction associated with cerebral white matter lesions ( leukoaraiosis ) in elderly patients without ischemic heart disease and stroke?
### Response:
| This investigation identified an association between LV diastolic dysfunction and WML. Further investigations are required to clarify whether there is a direct association between the two diseases. |
### Instruction:
Does peripheral blood mononuclear cells microRNA predict treatment outcome of hepatitis C virus genotype 1 infection?
### Response:
| PBMC-miR-125b expression levels were inversely related to the achievement of an SVR in HCV-1 patients, independent of interleukin-28B genotype, and was the single predictor of SVR in non-RVR patients. |
### Instruction:
Does activation of liver X receptors inhibit experimental fibrosis by interfering with interleukin-6 release from macrophages?
### Response:
| We identified LXRs as novel targets for antifibrotic therapies, a yet unknown aspect of these nuclear receptors. Our data suggest that LXR activation might be particularly effective in patients with inflammatory disease subtypes. Activation of LXRs interfered with the release of interleukin-6 from macrophages and, thus... |
### Instruction:
Does quality of life in patients with breast cancer and their rehabilitation need?
### Response:
| Breast cancer patients should be followed up for their quality of life and provided effective therapy for their physical and psychological problems. |
### Instruction:
Is the polymorphism of Insulin-like growth factor-I ( IGF-I ) related to osteoporosis and bone mineral density in postmenopausal population?
### Response:
| Our study suggests that polymorphism in IGF-I rs35767 was significantly associated with BMD and osteoporosis in postmenopausal female population, and polymorphism of rs35767 could be a marker for lower BMD and risk of osteoporosis. |
### Instruction:
Is psychosis in adulthood associated with high rates of ADHD and CD problems during childhood?
### Response:
| Previous views regarding PPA among patients with a psychotic illness may reflect an association between childhood ADHD/CD and later psychosis. The nature of this association remains uncertain: two disorders sharing some generative mechanisms or one disorder with two main clinical manifestations. Childhood ADHD and part... |
### Instruction:
Does albumin infusion improve renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury?
### Response:
| The data suggest that albumin infusion improves renal function in acutely decompensated cirrhotic patients with acute kidney injury by impacting on renal blood flow autoregulation. This is possibly achieved through endothelial stabilization and a reduction in the sympathetic tone, endotoxemia and oxidative stress. |
### Instruction:
Does a novel `` delayed start '' protocol with gonadotropin-releasing hormone antagonist improve outcomes in poor responders?
### Response:
| The delayed-start protocol improves ovarian response in poor responders by promoting and synchronizing follicle development without impairing oocyte developmental competence. |
### Instruction:
Does bDNF attenuate IL-1β-induced F-actin remodeling by inhibiting NF-κB signaling in hippocampal neurons?
### Response:
| Taken together, our findings indicate that BDNF acts as an F-actin-protective regulator during stimulation by IL-1β and that this function largely occurs via the regulation of NF- ĸB signaling. These results suggest that interventions targeting the BDNF signaling system may be of therapeutic value against major depress... |
### Instruction:
Does luteolin protect HUVECs from TNF-α-induced oxidative stress and inflammation via its effects on the Nox4/ROS-NF-κB and MAPK pathways?
### Response:
| Luteolin attenuates TNF-α-induced oxidative stress and inflammation via its effects on the Nox4/ROS-NF-κB and MAPK pathways. These results suggest that luteolin may provide a beneficial effect in treating vascular diseases associated with oxidative stress and inflammation. |
### Instruction:
Are bilaterally positive biopsy cores associated with non-organ-confined disease in prostate cancer patients eligible for active surveillance?
### Response:
| In our cohort, patients with bilaterally positive biopsy cores were significantly more likely to harbor a non-organ-confined tumor than patients with unilaterally positive cores. Due to their high specificity, bilaterally positive biopsies may represent a reasonable exclusion criterion for active surveillance if our re... |
### Instruction:
Is astrocytic JWA expression essential to dopaminergic neuron survival in the pathogenesis of Parkinson 's disease?
### Response:
| The JWA gene exerts neuroprotective roles against DA neuronal degeneration via modulating intracellular redox status and NF-κB signaling pathway and is a potential treatment target for PD. |
### Instruction:
Do new intragenic and promoter region deletion mutations in FERMT1 underscore genetic homogeneity in Kindler syndrome?
### Response:
| The present data provide evidence in support of genetic homogeneity in KS. |
### Instruction:
Does regular intake of high-oleic peanuts improve fat oxidation and body composition in overweight/obese men pursuing a energy-restricted diet?
### Response:
| Regular peanut consumption, especially the high-oleic type, within a hypocaloric-diet increased fat oxidation and reduced body fatness in overweigh and obese men. |
### Instruction:
Does mTHFR C677T variant reduce risk of sporadic Parkinson 's disease in ethnic Chinese?
### Response:
| We showed that the C677T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a Han Chinese population from mainland China. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary. |
### Instruction:
Does a Petiveria alliacea standardized fraction induce breast adenocarcinoma cell death by modulating glycolytic metabolism?
### Response:
| A fraction of Petiveria alliacea leaves and stems induces in vitro cell death and in vivo tumor regression in a murine breast cancer model. Our results validate in partly, the traditional use of Petiveria alliacea in breast cancer treatment, revealing a new way of envisioning Petiveria alliacea biological activity. The... |
### Instruction:
Does genetic deletion of toll-like receptor 4 on platelets attenuate experimental pulmonary hypertension?
### Response:
| Our data demonstrate that TLR4 on platelets contributes to the pathogenesis of PH and further highlights the role of platelets in PH. |
### Instruction:
Does green tea extract enhance parieto-frontal connectivity during working memory processing?
### Response:
| Our findings provide first evidence for the putative beneficial effect of green tea on cognitive functioning, in particular, on working memory processing at the neural system level by suggesting changes in short-term plasticity of parieto-frontal brain connections. Modeling effective connectivity among frontal and pari... |
### Instruction:
Does hemoglobin A1c predict heart failure hospitalization independent of baseline cardiac function or B-type natriuretic peptide level?
### Response:
| In patients with type 2 diabetes, HbA1c significantly predicts future HF hospitalization independent of baseline BNP level or echocardiographic parameters. |
### Instruction:
Does isoproterenol induce vascular oxidative stress and endothelial dysfunction via a Giα-coupled β2-adrenoceptor signaling pathway?
### Response:
| The β2-adrenoceptor/Giα signaling pathway is implicated in the enhanced vasoconstrictor response and eNOS uncoupling-mediated oxidative stress due to ISO treatment. Thus, long-term β2-AR activation might results in endothelial dysfunction. |
### Instruction:
Is risk of progression of early cervical lesions associated with integration and persistence of HPV-16 and expression of E6 , Ki-67 , and telomerase?
### Response:
| Overexpression of E6 and Ki-67 is associated with the integration of HPV-16, favoring viral persistence, and increasing the risk of progression in women with NSIL and LSIL. |
### Instruction:
Is thromboprophylaxis associated with reduced post-hospitalization venous thromboembolic events in patients with inflammatory bowel diseases?
### Response:
| Pharmacologic thromboprophylaxis during IBD-related hospitalization is associated with reduced risk of post-hospitalization VTE. |
### Instruction:
Is cruciferous vegetable intake inversely correlated with circulating levels of proinflammatory markers in women?
### Response:
| This study suggests that the previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables. |
### Instruction:
Does quercetin-rich onion peel extract suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes?
### Response:
| The results indicate that OPE treatment significantly prevents intracellular lipid accumulation via hyperactivation of genes regulating lipolysis as compared with quercetin alone. |
### Instruction:
Is chronic fatigue syndrome associated with the risk of fracture : a nationwide cohort study?
### Response:
| We propose that CFS-related fracture might not be associated with osteoporosis. The mechanism for developing CFS-related fracture remains unclear; however, we recommend noticing the prevention of fracture for CFS patients before clarifying the aetiology of CFS-related fracture. |
### Instruction:
Does prolongation of the QTc interval predict appropriate implantable cardioverter-defibrillator therapies in hypertrophic cardiomyopathy?
### Response:
| The findings from this study suggest that QTc interval prolongation is a novel clinical predictor of appropriate ICD therapy in HCM. |
### Instruction:
Does number of P-wave fragmentations on P-SAECG correlate with infiltrated atrial fat?
### Response:
| Infiltrated atrial fat correlates with discontinuous conduction on posterior LA wall and represents AF early substrate. |
### Instruction:
Do new miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney?
### Response:
| We identified novel miRNAs specific for each RCC subtype and UT-UC, we investigated their putative targets, the networks and pathways in which they participate and we functionally verified the true targets of the top deregulated miRNAs. |
### Instruction:
Does hepatic rather than cardiac steatosis relate to glucose intolerance in women with prior gestational diabetes?
### Response:
| There is no evidence of cardiac steatosis in middle-aged women with prior gestational diabetes, suggesting that cardiac complications might develop later in the time-course of diabetes and may be accelerated by the co-existence of further risk factors, whereas hepatic steatosis remains a valid biomarker for metabolic d... |
### Instruction:
Do multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex?
### Response:
| These results provide insight into the regulatory logic controlling Fezf2 expression and further the understanding of how multiple non-coding regulatory domains can collaborate to control gene expression in vivo. |
### Instruction:
Does cell-autonomous heparanase modulate self-renewal and migration in bone marrow-derived mesenchymal stem cells?
### Response:
| Our findings indicated cell-autonomous HPSE1 modulates clonogenicity, proliferative potential and migration of BM-MSCs and suggested the HS-GAGs may contribute to the niche microenvironment of BM-MSCs. |
### Instruction:
Does seven-day remote ischemic preconditioning improve local and systemic endothelial function and microcirculation in healthy humans?
### Response:
| Daily exposure to IPC for 7 days leads to local and remote improvements in brachial artery FMD and resting skin microcirculation that remain after cessation of the intervention and beyond the late phase of protection. These findings may have clinical relevance for micro- and macrovascular improvements. |
### Instruction:
Are central hemodynamics associated with cardiovascular disease and albuminuria in type 1 diabetes?
### Response:
| In type 1 diabetes patients, increased CASP and CPP and decreased CADP and SEVR were independently associated with history of CVD and albuminuria. Furthermore, SEVR predicted mortality and ESRD during follow-up. Future studies are needed to determine whether targeting central hemodynamics improves outcome. |
### Instruction:
Does cyclosporine a protect RGC-5 cells from excitotoxic cell death?
### Response:
| CSA can effectively protect RGC-5 cells against glutamate-induced excitotoxicity. Therefore, CSA should be tested in further experiments to evaluate its potential as a neuroprotective substance against RGC disorders. |
### Instruction:
Does metabolomics analysis reveal large effect of roughage types on rumen microbial metabolic profile in dairy cows?
### Response:
| The microbial metabolites in the rumen provide nutritional precursors that are critical for general health and milk production in dairy cows. However, studies of the effect of diet on ruminal microbial metabolism are scant. In our current study, we analysed the ruminal microbial metabolite profile of cows fed different... |
### Instruction:
Does body composition monitor assessing malnutrition in the hemodialysis population independently predict mortality?
### Response:
| BCM-diagnosed malnutrition in chronic hemodialysis patients is an independent predictor of mortality at up to 54 months follow-up and is associated with a 1.66-fold higher risk of dying compared with normal nutrition status. Whether intervention (e.g., nutritional supplementation) might improve nutrition and reduce the... |
### Instruction:
Is prolonged N200 the early neurophysiologic change in the patient with minimal hepatic encephalopathy?
### Response:
| N200 is a useful tool for assessing early changes of cognitive dysfunction in cirrhosis. It suggests that slower auditory cortical processing is the first sign of cerebral deterioration in patients with hepatic encephalopathy. |
### Instruction:
Does mother 's trauma during pregnancy affect fluctuating asymmetry in offspring 's face?
### Response:
| The experience of trauma during pregnancy can result in visible disturbances of development of offspring. A decreased level of cortisol is associated with psychosomatic disorders and may also be potentially responsible for disorders of homeostasis in the process of formation of such morphological structures of the face... |
### Instruction:
Does soluble urokinase plasminogen activator receptor predict mortality in patients with systemic inflammatory response syndrome?
### Response:
| suPAR plasma level determined at early SIRS is predictive for mortality. |
### Instruction:
Is a genetic variant in the microRNA-146a gene associated with susceptibility to alcohol use disorders?
### Response:
| This is the first genetic association study to explore the relationship of miRNA polymorphisms with AUDs and to show an association of the miR-146a C>G rs2910164 allelic variant with this disease. |
### Instruction:
Do not all patients need to be discussed in a colorectal cancer MDT meeting?
### Response:
| Discussion of routine cases of colon cancer in our MDT rarely changed management, but it did change the decisions regarding complex cases or in patients with unusual pathology. We propose a two-tiered approach to the MDT where all patients are listed for a MDT meeting but only patients with complex pathology are discus... |
### Instruction:
Do experiences of peer support for children and adolescents whose parents and siblings have mental illness?
### Response:
| Participants derived substantial personal benefit from peer support. Use of social media and the Internet may facilitate future program delivery. |
### Instruction:
Does auditory perceptual performance of children in the identification of contrast between stressed vowels?
### Response:
| The auditory perceptual ability concerning the identification of vowel contrasts is not yet established in the age group studied. The auditory perception of vowel contrasts occurs gradually and asymmetrically, as the order of acquisition in terms of production and perception was not always the same. |
### Instruction:
Is household size associated with unintelligible speech in children who have intellectual disabilities : A South African study?
### Response:
| Children living in dwellings with more people were less likely to have intelligible speech. The processes through which large household size might influence children's language are discussed. |
### Instruction:
Is the bone marrow hematopoietic microenvironment impaired in iron-overloaded mice?
### Response:
| Iron-overloaded (IO) mice did not show significant defects in the hematopoietic data of the peripheral blood. Myeloid progenitor cells in the bone marrow were increased in IO mice, but the number and function of the erythroid progenitors and hematopoietic stem cells were not significantly affected. However, bone marrow... |
### Instruction:
Is silver from polyurethane dressing delivered by gradient to exudate , tissue , and serum of patients undergoing negative-pressure wound treatment?
### Response:
| The high concentration of silver found in wound exudate reflects not only the affinity for silver in serum components and wound fluids, but also that most silver ions are not distributed systemically in the patient; instead, they are transported by the vacuum created by therapy. |
### Instruction:
Does maximal cardiac output determine 6 minutes walking distance in pulmonary hypertension?
### Response:
| Maximal cardiac output is elicited by 6MWT in PH patients with failing right ventricle. Cardiac output increase is dependent on chronotropic response in patients with PH. |
### Instruction:
Is in situ tumor PD-L1 mRNA expression associated with increased TILs and better outcome in breast carcinomas?
### Response:
| PD-L1 mRNA expression is identified in nearly 60% of breast tumors and it is associated with increased TILs and improved recurrence-free survival. These observations support the evaluation of PD-1/PD-L1-targeted therapies in breast cancer. |
### Instruction:
Does pre-procedure ultrasound increase the success and safety of central venous catheterization†?
### Response:
| Pre-procedure US for IJV catheterization is safe, quick, and superior to LM. |
### Instruction:
Do an unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria?
### Response:
| Screening only a subsection of our natural product library identified a small-molecule antibiotic adjuvant capable of sensitizing Gram-negative bacteria to antibiotics to which they are ordinarily intrinsically resistant. This result demonstrates the great potential of this approach in expanding antibiotic effectivenes... |
### Instruction:
Is nutritional status according to Mini Nutritional Assessment related to functional status in geriatric patients -- independent of health status?
### Response:
| Nutritional status according to MNA was related to ADL as well as to mobility in acute geriatric patients. This association remained after adjusting for health status. |
### Instruction:
Is serum immunoglobulin G4 level a poor predictor of immunoglobulin G4-related disease?
### Response:
| Elevated serum IgG4 levels are not specific for IgG4-RD and are likely to be a false-positive. Chronic rhinosinusitis is likely an as yet underrecognized manifestation of IgG4-RD. |
### Instruction:
Do carbon paste electrode modified with cuo-nanoparticles as a probe for square wave voltammetric determination of atrazine?
### Response:
| This easily fabricated electrode together with the fast and sensitive SW voltammetry was successfully applied for the determination of concentration of ATZ at trace levels, in different water samples. |
### Instruction:
Do co-morbid anxiety disorders predict early relapse after inpatient alcohol treatment?
### Response:
| Alcohol dependence is a severe mental disorder, with high relapse rates and high mortality. Alcohol dependent patients with co-morbid anxiety disorders are particularly prone to relapse during the first three months of treatment. These patients may therefore require additional medical and psychological attention. |
### Instruction:
Do accelerated orthodontic tooth movement following le fort I osteotomy in a rodent model?
### Response:
| Le Fort I osteotomy significantly accelerated the rate of orthodontic tooth movement. Histologically, more active and extensive bone remodeling was observed after osteotomy. |
### Instruction:
Is visual working memory capacity for color independent of representation resolution?
### Response:
| This result suggests that VWM always represents a fixed number of approximately 3-4 colors regardless of the resolution of representation. |
### Instruction:
Is cardiac responses to β-adrenoceptor stimulation partly dependent on mitochondrial calcium uniporter activity?
### Response:
| Inhibition of the mitochondrial Ca(2+) uniporter decreases β-adrenoceptor response, uncoupling between workload and production of energetic metabolites. Our results support the hypothesis that the coupling of workload and energy supply is partly dependent on mitochondrial Ca(2+) uniporter activity. |
### Instruction:
Does restricted intravenous fluid regimen reduce fluid redistribution of patients operated for abdominal malignancy?
### Response:
| Perioperative fluid restriction could effect on fluid distribution and reduce tissue and cellular edema, and further, could reduce postoperative complication rates. |
### Instruction:
Does sub-Tenon block provide superior postoperative analgesia vs intravenous fentanyl in pediatric squint surgery?
### Response:
| Use of sub-Tenon block does not decrease the incidence of postoperative pain significantly in children undergoing squint surgery. However, it leads to a statistically significant decrease in the incidence of intraoperative OCR and PONV in the early recovery period in these patients. |
### Instruction:
Does inhibition of the phosphoinositide 3-kinase pathway decrease innate resistance to lipopolysaccharide toxicity in TLR4 deficient mice?
### Response:
| In this study, we demonstrate that innate resistance to LPS toxicity in Tlr4-/- mice is impaired by inhibition of the PI3K pathway, with a corresponding increase in mortality and production of tissue O₂⁻ and inflammatory cytokines. |
### Instruction:
Does serine protease inhibitor Kazal type 1 promote epithelial-mesenchymal transition through EGFR signaling pathway in prostate cancer?
### Response:
| These findings suggest that SPINK1 promotes EMT through EGFR signaling pathway in PCa and SPINK1 could be a new prognostic marker in Chinese PCas. |
### Instruction:
Is alexithymia associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population : the Hisayama Study?
### Response:
| The findings demonstrate that, in the general population, higher levels of alexithymia are associated with a higher risk of having chronic pain. The early identification and treatment of alexithymia and negative affect may be beneficial in preventing chronic pain and reducing the clinical and economic burdens of chroni... |
### Instruction:
Does activation of autophagy protect against ROS-mediated mitochondria-dependent apoptosis in L-02 hepatocytes induced by Cr ( VI )?
### Response:
| ROS production is a critical reason for Cr(VI)-induced mitochondria-dependent apoptosis. And activation of autophagy could repair mitochondria function to protect hepatocytes potentially by removing damaged mitochondria. |
### Instruction:
Are urinary incontinence management costs reduced following Burch or sling surgery for stress incontinence?
### Response:
| Following Burch or fascial sling surgery, the UI management cost at 24 months decreased by 72% ($625 per woman per year) and was strongly associated with decreasing UI frequency. Reduced out-of-pocket expenses may be a benefit of these established urinary incontinence procedures. |
### Instruction:
Are performance related factors the main determinants of the von Willebrand factor response to exhaustive physical exercise?
### Response:
| VWF:Ag levels strongly increase upon exhaustive exercise and this increase is strongly determined by physical fitness level and the intensity of the exercise, while there is no clear effect of genetic variation in STXBP5, STX2 and the VWF promoter. |
### Instruction:
Does next-generation sequencing identify germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer?
### Response:
| Germline MRE11A SNP rs1805363 was predictive of RT, but not of cystectomy outcome in MIBC. If successfully validated in an independent RT-treated cohort, this SNP could be a useful clinical tool for selecting patients for bladder-conserving treatment. |
### Instruction:
Is soluble CD163 , a macrophage activation marker , independently associated with fibrosis in patients with chronic viral hepatitis B and C?
### Response:
| sCD163 levels are increased in patients with chronic viral hepatitis, reflecting macrophage activation. Increased sCD163 is associated with the severity of disease and predicts fibrosis. A sCD163-based fibrosis score, CD163-HCV-FS, is superior to APRI and FIB-4 for the diagnosis of significant fibrosis in patients with... |
### Instruction:
Does hyaluronidase modulate bleomycin-induced lung injury detected noninvasively in small rodents by radial proton MRI?
### Response:
| The present data indicate that hyaluronic acid contributes to the bleomycin-induced responses detected by MRI in the lung. |
### Instruction:
Do an update on metabolic assessment in patients with urinary lithiasis?
### Response:
| Urinary metabolic disturbances were diagnosed in 96.8 % of patients in the study. These results warrant metabolic study and follow-up in patients with recurrent lithiasis in order to decrease recurrence rate through specific treatments, modification in alimentary, and behavioral habits. |
### Instruction:
Do regional tissue oxygen saturation measured by near-infrared spectroscopy to assess the depth of burn injuries?
### Response:
| This study suggests that NIRS determination of rSO2 in burn injuries shows promise as a reliable and quick method to estimate the depth of burn lesion. |
### Instruction:
Does hPV DNA and Pap smear test result in cases with and without cervical pathology?
### Response:
| HPV positivity in our hospital setting is low which is compatible with other studies in Turkey. In positive HPV cases there is a good correlation between HPV type and positive cervical biopsy results. |
### Instruction:
Are occupational noise exposure and noise-induced hearing loss associated with work-related injuries leading to admission to hospital?
### Response:
| From a safety perspective, this issue is highly relevant; especially when workers are exposed to intense ambient noise and NIHL. |
### Instruction:
Is the thrombospondin-1 receptor CD36 an important mediator of ovarian angiogenesis and folliculogenesis?
### Response:
| The results from this study demonstrate that CD36 is integral to the regulation of ovarian angiogenesis by TSP-1 and the expression of these family members may be useful in the control of ovarian vascular disorders. |
### Instruction:
Does a pangenomic analysis of the Nannochloropsis organellar genomes reveal novel genetic variations in key metabolic genes?
### Response:
| Many organellar gene modifications in Nannochloropsis are unique and deviate from conserved orthologs found across the tree of life. Implementation of secondary and tertiary structure prediction was crucial to functionally characterize many proteins and therefore should be implemented in automated annotation pipelines.... |
### Instruction:
Does the CJIE1 prophage of Campylobacter jejuni affect protein expression in growth media with and without bile salts?
### Response:
| The presence of the CJIE1 prophage was associated with differences in protein expression levels under different conditions. Further work is required to determine what genes are involved in causing this phenomenon. |
### Instruction:
Does calponin1 inhibit dilated cardiomyopathy development in mice through the εPKC pathway?
### Response:
| εPKC/ERK/mTOR pathway activation induced by the rescued expression of CNN1 contributed to the improvement of cardiac dysfunction and pathological changes observed in the DTG mice. CNN1 could be a therapeutic target to prevent the development of DCM and heart failure (HF). |
### Instruction:
Is the anti-tumor activity of Antrodia salmonea in human promyelocytic leukemia ( HL-60 ) cells mediated via the induction of G₁ cell-cycle arrest and apoptosis in vitro or in vivo?
### Response:
| To the best of our knowledge, this is the first report confirming the anti-tumor activity of this potentially beneficial mushroom against human promyelocytic leukemia. |
### Instruction:
Does subclinical alexithymia modulate early audio-visual perceptive and attentional event-related potentials?
### Response:
| Our findings suggest that high-alexithymic scorers require heightened early attentional resources in comparison to low scorers, particularly when confronted with emotional bimodal stimuli. |
### Instruction:
Does truncal fat distribution correlate with decreased vital capacity in Duchenne muscular dystrophy?
### Response:
| Truncal fat distribution is a significant predictor of lower vital capacity in boys with DMD, whereas BMI has a positive effect. |
### Instruction:
Does erythropoietin improve the healing of skin necrosis resulting from Doxorubicin extravasation in a rat model?
### Response:
| In this study using female Sprague-Dawley rats, EPO treatment improved the healing of skin necrosis caused by doxorubicin injection. This finding may lead to a new therapeutic approach for the management of skin necrosis caused by doxorubicin extravasation. |
### Instruction:
Is ankaferd blood stopper more effective than adrenaline plus lidocaine and gelatin foam in the treatment of epistaxis in rabbits?
### Response:
| Topical nasal ABS application controlled epistaxis faster than C, GF, and AL in this animal bleeding model. The bleeding model used here might fail to replicate the type of injury that would be likely to result in life-threatening bleeding in humans, which should be considered a limitation of the present study. The his... |
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