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### Instruction:
Do composted organic wastes from the pharmaceutical and agro-food industries induce soil bioactivity and nodulation in alfalfa?
### Response:
| TPOMW serves as an effective ground material for co-composting with liquid wastes such as FPH. TPOMW supplies key nutrients and stimulates nodulation in alfalfa. |
### Instruction:
Does decichine enhance hemostasis of activated platelets via AMPA receptors?
### Response:
| Dencichine administered orally shortened tail bleeding time, reduced APTT and TT but increased the concentration of FIB in plasma in a dose-dependent manner. When induced with trap, dencichine could elevate the cytoplasmic concentration of calcium, and secretion of TXA₂ as well as the ratio of TXA₂ to PGI₂ from platele... |
### Instruction:
Does spectral analysis of the heart sound in children with and without pulmonary artery hypertension?
### Response:
| Heart sound signals of patients with PAH contain significantly less relative power in the band 21-22 Hz compared to subjects with normal PAp. Information contained in the frequency domain may be useful in diagnosing PAH and aid the development of auscultation based techniques for diagnosing PAH. In the future, utilizin... |
### Instruction:
Is accumulation of subcutaneous fat , but not visceral fat , a predictor of adiponectin levels in preterm infants at term-equivalent age?
### Response:
| Subcutaneous fat accumulation contributes to increased levels of T-Ad and HMW-Ad, while visceral fat accumulation does not influence adiponectin levels in preterm infants at term-equivalent age. |
### Instruction:
Does follistatin-like protein 1 regulate chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells?
### Response:
| FSTL1 is a potent regulator of chondrocyte proliferation, differentiation and expression of ECM molecules. Our findings may lead to the development of novel strategies for cartilage repair and provide new disease-modifying treatments for OA. |
### Instruction:
Does modulation of sebum oxidation and interleukin-1α levels associate with clinical improvement of mild comedonal acne?
### Response:
| The data further support the involvement of lipid oxidation and particularly by-products of squalene oxidation in comedogenesis. |
### Instruction:
Does m30 predict the severity of hepatosteatosis , whereas adiponectin level declined with increase of ALT and the severity of hepatic steatosis?
### Response:
| M30 level in serum increased with the appearance of hepatic steatosis and had a positive correlation with a noninvasive hepatic injury test, BARD (BMI, aspartate aminotransferase [AST]/alanine aminotransferase [ALT] ratio [AAR], diabetes mellitus [DM]) index. Adiponectin level decreased with the increasing ALT level an... |
### Instruction:
Is deregulation of COMMD1 associated with poor prognosis in diffuse large B-cell lymphoma?
### Response:
| COMMD1 is a potential novel prognostic factor in DLBCLs. The results highlight the value of integrated comprehensive analysis to identify prognostic markers and genetic driver events not previously implicated in DLBCL. |
### Instruction:
Does a supportive family environment in childhood enhance the level and heritability of sense of coherence in early adulthood?
### Response:
| Genetic factors are important for SOC, but genetic influences are much greater in supportive family environments. This emphasizes the importance of childhood home for the development of strong SOC. |
### Instruction:
Is the seizure , not electricity , essential in convulsive therapy : the flurothyl experience?
### Response:
| The brain seizure, not the method of induction, is the essential element in the efficacy of convulsive therapy. Seizure induction with chemicals avoids the direct effects of electricity on brain functions with lesser effects on cognition. Reexamination of chemical inductions of seizures as replacements for electricity ... |
### Instruction:
Do mannose-binding lectin 2 ( MBL2 ) gene polymorphisms influence frequency of infections in chronic lymphocytic leukemia patients?
### Response:
| To the authors' knowledge, this is the first study describing the association between MBL2 polymorphisms and infectious disease in chronic lymphocytic leukemia. Although it was not possible to demonstrate any influence of MBL2 polymorphisms as a genetic modulator of infection in chronic lymphocytic leukemia, the author... |
### Instruction:
Do temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells?
### Response:
| Based on these data, we propose TEM with or without chloroquine as a new treatment option for CRC. |
### Instruction:
Is c-X-C motif chemokine 13 ( CXCL13 ) a prognostic biomarker of idiopathic pulmonary fibrosis?
### Response:
| CXCL13 is increased and is a prognostic biomarker in patients with IPF, and more so than in patients with COPD. This contrast indicates CXCL13 overexpressions are intrinsic to IPF, rather than an epiphenomenon of lung injury. The present data implicate CXCL13 and B cells in IPF pathogenesis, and support considerations ... |
### Instruction:
Does calcitriol modulate receptor for advanced glycation end products ( RAGE ) in diabetic hearts?
### Response:
| Calcitriol decreased diabetic effects on RAGE and fibrosis, which may be caused by its modulation on AT1R and the anti-inflammatory and antioxidative potentials. Therefore, calcitriol may attenuate diabetic cardiomyopathy. |
### Instruction:
Does n-acylhydrazone derivative ameliorate monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity?
### Response:
| The RV systolic pressure was elevated in the PAH model and reduced from 49.6 ± 5.0 mm Hg (MCT group) to 27.2 ± 2.1 mm Hg (MCT+LASSBio-1386 group; P<0.05). MCT administration also impaired the EC, increased the RV and pulmonary arteriole size, and promoted endothelial dysfunction of the pulmonary artery rings. In the PA... |
### Instruction:
Is reduction of circulating endothelial progenitor cell level associated with contrast-induced nephropathy in patients undergoing percutaneous coronary and peripheral interventions?
### Response:
| Decreased EPC level is associated with a greater risk of CIN, which may explain part of the pathophysiology of CIN and the poor prognosis in CIN patients. |
### Instruction:
Is propionyl-L-Carnitine Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature?
### Response:
| Our results show that the beneficial antioxidant effect of PLC targeting intestinal microvasculature restores endothelial β-oxidation and function, and reduces mucosal inflammation in UC patients. |
### Instruction:
Does virstatin inhibit biofilm formation and motility of Acinetobacter baumannii?
### Response:
| By its action on pili biogenesis, virstatin demonstrated a very promising antibiofilm activity affecting more than 70% of the A. baumannii clinical isolates. |
### Instruction:
Is hbA1c associated with increased all-cause mortality in the first year after acute ischemic stroke?
### Response:
| Elevated HbA1c (from 5.5% [37 mmol/mol]) presenting pre-stroke glycemia status has a significant trend in increasing the risk of 1-year all-cause mortality. HbA1c ≥ 7.2% (>55 mmol/mol) is an independent risk predictor for 1-year all-cause mortality after acute first-ever ischemic stroke. Such an association might be al... |
### Instruction:
Is pre-mixing serum samples with assay buffer a prerequisite for reproducible anti-Mullerian hormone measurement using the Beckman Coulter Gen II assay?
### Response:
| Pre-mixing serum samples with assay buffer is a prerequisite for reproducible measurement of AMH in serum using the Beckman Coulter Gen II assay. |
### Instruction:
Does smooth muscle cell-specific Hif-1α deficiency suppress angiotensin II-induced vascular remodelling in mice?
### Response:
| Our results revealed that SMC-derived Hif-1α is a crucial mediator of Ang II-induced vascular remodelling. |
### Instruction:
Does nicotine acutely inhibit erectile tumescence by altering heart rate variability?
### Response:
| HRV mediated the association between nicotine ingestion and erectile capacity. Findings suggest that dysfunctional cardiac autonomic tone may be an underlying mechanism by which nicotine exerts its deleterious effects on erectile health. |
### Instruction:
Is repressor element-1 silencing transcription factor ( REST ) present in human control and Huntington 's disease neurones?
### Response:
| These data support the notion of REST presence in human brain neurones and glial cells and indicate the importance of developing compounds able to restore REST-regulated transcription of neuronal genes in HD. |
### Instruction:
Do elevated plasma D-dimer levels correlate with long term survival of gastric cancer patients?
### Response:
| Plasma D-dimer levels are increased in gastric cancer patients and may be a valuable biomarker for peritoneal dissemination, with high D-dimer levels predicting poor outcomes for gastric cancer patients. |
### Instruction:
Does circulating betatrophin correlate with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals?
### Response:
| Betatrophin is a recently identified hormone, the circulating concentrations of which are unaltered in human insulin resistance but correlate significantly with atherogenic lipid profiles in high-risk cohorts with morbid obesity or type 2 diabetes. Betatrophin could therefore be a novel pathomechanistic player in dysfu... |
### Instruction:
Does valproic acid prevent penile fibrosis and erectile dysfunction in cavernous nerve-injured rats?
### Response:
| HDAC-induced pathological signaling in response to BCNI contributes to penile vascular dysfunction. Pharmacological inhibition of HDAC prevents penile fibrosis, normalizes fibronectin expression, and preserves erectile function. The HDAC pathway may represent a suitable target in preventing the progression of ED occurr... |
### Instruction:
Does the anti-hypercholesterolemic effect of low p53 expression protect vascular endothelial function in mice?
### Response:
| Our data demonstrate that low endogenous p53 expression prevents the rise in circulating levels of cholesterol when fed a WD. Consequently, the endothelial stress of hypercholesterolemia is absent in young p53+/- mice as evidenced by the absence of endothelial adaptive pathway over-activation to minimize stress-related... |
### Instruction:
Do postradiotherapy CA19-9 kinetics correlate with outcomes in patients with pancreatic adenocarcinoma?
### Response:
| CA19-9 kinetics after RT correlate with disease progression and survival and could serve as a prognostic tool to guide treatment decisions. |
### Instruction:
Are intramural location and size of arterial calcification associated with stenosis at carotid bifurcation?
### Response:
| ICA stenosis was strongly associated with severe calcification located mainly outside the carotid plaque. Outside calcification at the ICA origins should be evaluated separately from inside calcification, as a marker for the ICA stenosis. Additionally, we found that calcification at the origins of the cervical arteries... |
### Instruction:
Does nanomicelle formulation modify the pharmacokinetic profiles and cardiac toxicity of daunorubicin?
### Response:
| Leukemia stem cell-targeting micelles dramatically change the pharmacokinetics and reduce the cardiac toxicity of DNR, which may enable improved DNR-based treatment of acute myeloid leukemia. |
### Instruction:
Does triiodothyronine induce proliferation of pancreatic β-cells through the MAPK/ERK pathway?
### Response:
| Our results demonstrate that MAPK/ERK pathway plays an important role in the T3 induced pancreatic beta cell proliferation. |
### Instruction:
Is transient erythroblastopenia of childhood an underdiagnosed and self-limiting disease?
### Response:
| Transient erythroblastopenia of childhood is now diagnosed less frequently in our institution than in the last two decades. Although the aetiology remains largely unknown, it is possible that changes in causative environmental factors contribute to making TEC a rare disease. Clinicians need to be aware of TEC in order ... |
### Instruction:
Do cOX-2-independent effects of celecoxib sensitize lymphoma B cells to TRAIL-mediated apoptosis?
### Response:
| These data suggest new potent strategies for NHL therapy combining drugs targeting both tumor B cells and survival signals provided by the tumor microenvironment. |
### Instruction:
Is guttate psoriasis associated with an intermediate phenotype of impaired Langerhans cell migration?
### Response:
| We have shown that guttate psoriasis is associated with an abnormality of LC mobilization, but a less marked inhibition compared with that seen in CPP. In resolved guttate psoriasis LC function returns to normal. These data provide further evidence that the pathogenesis of psoriasis is characterized by significant chan... |
### Instruction:
Do overexpression of stearoyl-CoA desaturase 1 in bone marrow mesenchymal stem cells enhance the expression of induced endothelial cells?
### Response:
| This study suggested that overexpression of SCD1 in BM-MSCs could increase the expression of induced endothelial cells in vitro. |
### Instruction:
Does nobiletin restore impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation?
### Response:
| Nobiletin restores reduced mitochondrial metabolism in hypothyroid rat hippocampus through acceleration of matrix substrate-level phosphorylation that may be important for the prevention of hypometabolic complications in neurological disorders. |
### Instruction:
Does plasma lipidomic analysis predict non-calcified coronary artery plaque in asymptomatic patients at intermediate risk of coronary artery disease?
### Response:
| Plasma lipidomic analysis can predict the burden of non-calcified coronary plaque in asymptomatic subjects at intermediate risk of CAD. Re-stratification of these patients by plasma lipid profiling may enable more appropriate and effective primary prevention management strategies. |
### Instruction:
Is vascular calcification associated with increased ambulatory central aortic systolic pressure in prevalent dialysis patients?
### Response:
| Vascular calcification was not associated with changes in ambulatory central aortic systolic pressure in this cohort of prevalent dialysis patients. Inter-dialytic blood pressure and CASP correlated very well with ambulatory measurement. |
### Instruction:
Is bacteraemia due to Streptococcus gallolyticus subspecies pasteurianus associated with digestive tract malignancies and resistance to macrolides and clindamycin?
### Response:
| Extensive diagnostic work-up for digestive tract malignancies and trans-esophageal echocardiogram should be investigated in patients with bacteraemia caused by S. gallolyticus. |
### Instruction:
Does cardiopulmonary fitness correlate with regional cerebral grey matter perfusion and density in men with coronary artery disease?
### Response:
| Perfusion and GM density were associated with fitness at baseline and with greater fitness gains with exercise. This study identifies new neurobiological correlates of fitness and demonstrates the utility of multi-modal MRI to evaluate the effects of exercise in CAD patients. |
### Instruction:
Does increasing mean arterial blood pressure and heart rate with catecholaminergic drugs improve the microcirculation in children with congenital diaphragmatic hernia : a prospective cohort study?
### Response:
| Catecholaminergic drug support with dopamine, norepinephrine, and/or epinephrine improved macrocirculatory function but did not improve the microcirculation in neonates with congenital diaphragmatic hernia. The microcirculation was not only impaired but it also predicted poor outcome. |
### Instruction:
Is unfractionated heparin activity measured by anti-factor Xa levels associated with the need for extracorporeal membrane oxygenation circuit/membrane oxygenator change : a retrospective pediatric study?
### Response:
| Higher anti-Factor Xa concentrations were associated with freedom from circuit/membrane oxygenator change due to thrombus formation in pediatric patients during extracorporeal membrane oxygenation support. Activated clotting time measurements did not differ significantly between groups with or without circuit/membrane ... |
### Instruction:
Is age-related reduced prefrontal-amygdala structural connectivity associated with lower trait anxiety?
### Response:
| These findings argue against the notion that greater amygdala-vPFC structural integrity facilitates better anxiety outcomes in healthy adults. Instead, our results suggest that white matter degeneration in this network relates to lower anxiety in older adults. |
### Instruction:
Is the compound BTB06584 an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase?
### Response:
| BTB may represent a valuable tool to selectively inhibit mitochondrial F1 Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATPsynthase. |
### Instruction:
Is thioredoxin interacting protein ( TXNIP ) a novel tumor suppressor in thyroid cancer?
### Response:
| Our findings indicate that TXNIP functions as a tumor suppressor in thyroid cells, and its downregulation is likely important in the transition from differentiated to advanced thyroid cancer. These studies underscore the potential of TXNIP as a novel therapeutic target and prognostic indicator in advanced thyroid cance... |
### Instruction:
Does vaginal lactoferrin administration before genetic amniocentesis decrease amniotic interleukin-6 levels?
### Response:
| Vaginal LF administration decreases amniotic IL-6 concentration. We therefore suggest that the glycoprotein may exert a protective role against ominous pregnancy complications linked to an increased level of the cytokine, such as abortion secondary to amniocentesis. |
### Instruction:
Is the antibacterial effect of nitric oxide against ESBL-producing uropathogenic E. coli improved by combination with miconazole and polymyxin B nonapeptide?
### Response:
| An NO-donor in combination with miconazole and PMBN showed enhanced antimicrobial effects and proved effective against multidrug-resistant ESBL-producing uropathogenic E. coli. |
### Instruction:
Do fundic gland polyps accurately predict a low risk of future gastric carcinogenesis?
### Response:
| Sporadic FGPs tend to be related to the least atrophic mucosa among non-gastric atrophy subjects without H. pylori infection, and can be used as predictors of a low risk of gastric carcinogenesis. |
### Instruction:
Does variation in the location of the shoe sole flexion point influence plantar loading patterns during gait?
### Response:
| The findings of this study indicate that the location of the sole flexion point of the shoe influences plantar loading patterns during gait. Specifically, shoes with a sole flexion point located under the midfoot significantly decrease the magnitude and duration of loading under the midfoot and hindfoot, which may be i... |
### Instruction:
Do women with greater pelvic floor muscle strength have better sexual function?
### Response:
| Our findings suggest that women with stronger pelvic floor muscles have better sexual function. |
### Instruction:
Is acute mountain sickness repeatable across two 12-hour normobaric hypoxia exposures?
### Response:
| The LLS was not repeatable across 2 identical hypoxic exposures. Increased familiarity with the environment (not acclimation) could explain the reduced AMS severity on the second hypoxic exposure. Headache was the most reliable AMS symptom. |
### Instruction:
Does vaccine delivery to the oral cavity using coated microneedles induce systemic and mucosal immunity?
### Response:
| In conclusion, this study provides a novel method using microneedles to induce systemic IgG and secretory IgA in saliva, and could offer a versatile technique for oral mucosal vaccination. |
### Instruction:
Does obesity increase morbidity of laparoscopic cholecystectomy?
### Response:
| This study demonstrates that overall conversion rates and surgical morbidity are relatively low following LC, even in obese and morbidly obese patients. |
### Instruction:
Is laparoscopic surgery for gastric gastrointestinal stromal tumor feasible irrespective of tumor size?
### Response:
| Laparoscopic resection of primary gastric GISTs is feasible even for tumors of >5 cm. |
### Instruction:
Does heat shock protein complex vaccination induce protection against Helicobacter pylori without exogenous adjuvant?
### Response:
| H. pylori HspC vaccines have the potential to overcome some of the issues preventing the development of a human vaccine against this pathogen: HspC induced protective immunity against H. pylori without addition of an adjuvant and without the induction of a severe inflammatory response. However, complete protection was ... |
### Instruction:
Does tibialis posterior tendon transfer correct the foot drop component of cavovarus foot deformity in Charcot-Marie-Tooth disease?
### Response:
| Tibialis posterior tendon transfer was effective at correcting the foot drop component of cavovarus foot deformity in patients with Charcot-Marie-Tooth disease, with the transfer apparently working as an active substitution. Although passive plantar flexion was not limited after surgery, active plantar flexion at push-... |
### Instruction:
Does decanucleotide insertion polymorphism of F7 significantly influence the risk of thrombosis in patients with essential thrombocythemia?
### Response:
| Our results illustrate that the risk of thrombosis in MPN is significantly multiplied by inherited thrombophilic SNPs. This result points to the importance of a combined consideration of the inherited and the acquired hypercoagulable state in patients with MPN. Larger studies are needed to confirm and extend these impo... |
### Instruction:
Is pitavastatin a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin?
### Response:
| The results indicate that pitavastatin is a more sensitive and selective and thus preferred clinical OATP1B probe substrate than rosuvastatin, and that a single IV dose of rifampicin is a more selective OATP1B inhibitor than a PO dose. |
### Instruction:
Do cardiac magnetic resonance parameters predict transplantation-free survival in patients with fontan circulation?
### Response:
| CMR-derived ventricular indexed end-diastolic volume is an independent predictor of transplantation-free survival in patients late after the Fontan operation and adds incremental value over clinical symptoms alone for risk stratification. |
### Instruction:
Do bisphosphonates inhibit bone remodeling in the jaw bones of rats and delay healing following tooth extractions?
### Response:
| Combined treatment with ZA and DX over a prolonged period inhibits bone remodeling and increased sequestra formation to a greater extent than either drug alone. Trauma caused by these sequestra cutting through the mucosa could play a key role in the development of BRONJ by potentially facilitating infection. ZA withdra... |
### Instruction:
Is increased 8-hydroxydeoxyguanosine in high-grade gliomas associated with activation of autophagy?
### Response:
| Our study provides evidence that high levels of oxidative stress in high-grade gliomas are associated with autophagy activation that may play a protective role promoting the survival of high-grade gliomas under severe oxidative stress. |
### Instruction:
Do runners in their forties dominate ultra-marathons from 50 to 3,100 miles?
### Response:
| The running speed of the fastest competitors increased for both women and men in 100-mile events but only for women in 50-mile events. The age of peak running speed increased in men with increasing race distance to approximately 45 years in 1,000-mile events, whereas it decreased to approximately 39 years in 3,100-mile... |
### Instruction:
Does lower limb joint motion during a cross cutting movement differ in individuals with and without chronic ankle instability?
### Response:
| CAI subjects exhibited an altered pattern of the proximal joint kinematics during a cross-cutting movement. It is important for clinicians to assess the function of the hip and knee as well as the ankle, and to incorporate coordination training for the entire lower limb into rehabilitation after lateral ankle sprains. |
### Instruction:
Are basal cell carcinomas of the ear more aggressive than on other head and neck locations?
### Response:
| Limitations include single-center design and lack of long-term follow-up. |
### Instruction:
Does hIV infection predispose skin to toxic epidermal necrolysis via depletion of skin-directed CD4⁺ T cells?
### Response:
| This study is limited by small sample sizes. |
### Instruction:
Is sAPS 3 superior to SAPS 2 in cardiac surgery patients?
### Response:
| Despite including cardiac surgery patients, SAPS3 was not superior to SAPS2 in our analysis. In this large cohort of ICU cardiac surgery patients, performance of both SAPS models was generally poor. In this subset of patients, neither scoring system is recommended. |
### Instruction:
Do integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction?
### Response:
| Integrins αvβ5 and αvβ3 both control myofibroblast differentiation by activating latent TGF-β1. Pharmacological targeting of mesenchymal integrins is a possible strategy to selectively block TGF-β1 activation by cardiac myofibroblasts and progression of fibrosis in the heart. |
### Instruction:
Does colonoscopy with magnetic control system to navigate the forepart of colonoscope shorten the cecal intubation time?
### Response:
| Conducting colonoscopy with MCS is safe and smooth, and shortens the cecal intubation time by navigating the forepart of the colonoscope. In addition, all diagnostic and therapeutic benefits of conventional colonoscopy are retained. |
### Instruction:
Is gender influence on long-term weight loss after three bariatric procedures : gastric banding less effective in males in a retrospective analysis?
### Response:
| From our experience, we suggest that GB not to be offered as a first choice for obese male patients. |
### Instruction:
Does integrative analysis reveal novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats?
### Response:
| The integrated analysis reported here allowed the identification of novel mechanisms and key molecules involved in peripancreatic adipose tissue interrelation with beta cells during the development of obesity; this might help the development of novel strategies to prevent type 2 diabetes. |
### Instruction:
Is expression and activity of Rac1 negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse?
### Response:
| We conclude that hyperandrogenization (PCOS) by DHEA diminishes ovarian Rac1 and Vav expression and activity along with an increase in expression of Caveolin1. This is accompanied by an increase in the intra-ovarian level of '17 β-estradiol and inhibin B. |
### Instruction:
Is the pemetrexed-containing treatments in the non-small cell lung cancer -/low thymidylate synthase expression better than +/high thymidylate synthase expression : a meta-analysis?
### Response:
| -/low expression of TS was associated with higher objective response in NSCLC patients treated with pemetrexed-containing chemotherapy. TS may be a suitable marker of sensitivity to pemetrexed-based chemotherapy in patients with NSCLC. |
### Instruction:
Do n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis?
### Response:
| In a murine model of steatohepatitis, supplementation with n-3 PUFA and OO is associated with more severe necro-inflammation and fibrosis than in mice treated with OO only. |
### Instruction:
Do using ecological momentary assessment to understand where and with whom adults ' physical and sedentary activity occur?
### Response:
| The current study shows how EMA via mobile phones and accelerometers can be combined to offer an innovative approach to assess the contexts of adults' daily physical and sedentary activity. Future studies could consider utilizing this method in more representative samples to gather context-specific information to infor... |
### Instruction:
Are vitamin D deficiency and corticosteroid use risk factors for low bone mineral density in inflammatory bowel disease patients?
### Response:
| Low vitamin D, male gender, Asian ethnicity, CD, and corticosteroid use significantly increased the risk of having low BMD, while age and disease location did not affect BMD in our IBD population. It remains important to evaluate for vitamin D nutritional deficiency and limit corticosteroid use to help prevent low BMD ... |
### Instruction:
Does ethanol extract of Butea monosperma bark modulate dyslipidemia in streptozotocin-induced diabetic rats?
### Response:
| The findings suggest that BMBE supplementation could ameliorate dyslipidemia in DM. |
### Instruction:
Does adhesion molecule expression and function of primary endothelial cells in benign and malignant tissues correlate with proliferation?
### Response:
| This method provides a powerful tool to generate high yields of viable, primary ECs of different origins. The results suggest that an altered expression of adhesion molecules on ECs in proliferating tissues contribute to loss of EC function that might cause a chaotic tumor vasculature. |
### Instruction:
Is systematic age-related differences in chronic disease management in a population-based cohort study : a new paradigm of primary care required?
### Response:
| Our study shows that more effort is needed to ensure that primary health care systems are sensitive to chronic conditions in the young and in the very elderly. |
### Instruction:
Does network analysis reveal roles of inflammatory factors in different phenotypes of kidney transplant patients?
### Response:
| The study demonstrated the potential value of PPINs-based approach to understanding inflammation-derived mechanisms and developing diagnostic biomarkers. Independent evaluations are required to further estimate the clinical relevance of the new diagnostic biomarkers. |
### Instruction:
Is blood thrombogenicity independently associated with serum TSH levels in post-non-ST elevation acute coronary syndrome?
### Response:
| Serum TSH levels, particularly in the SCH range, are associated with higher thrombus burden despite optimal recommended secondary prevention therapy after NSTE-ACS. This may explain the higher CV risk seen in SCH patients. Future trials to assess the effect of individualized antithrombotic as well as thyroid hormone re... |
### Instruction:
Does corticomotor excitability of arm muscles modulate according to static position and orientation of the upper limb?
### Response:
| Results provide evidence that overall corticomotor excitability can be modulated according to multi-joint upper limb posture. |
### Instruction:
Does intrauterine Candida albicans infection elicit severe inflammation in fetal sheep?
### Response:
| Acute colonization of the amniotic cavity by C. albicans causes severe intrauterine inflammation and fetal injury. C. albicans is a potent fetal pathogen that can contribute to adverse pregnancy outcomes. |
### Instruction:
Is the Notch pathway important in maintaining the cancer stem cell population in pancreatic cancer?
### Response:
| The Notch signaling pathway is important in maintaining the pancreatic CSC population and is a potential therapeutic target in pancreatic cancer. |
### Instruction:
Are depressive symptoms associated with forearm bone accrual during adolescence?
### Response:
| Depressive symptoms, with the range of severity observed in the general adolescent population, were not associated with changes in forearm bone mineral density during adolescence. Further research based on measurements of different skeletal sites is needed in order to detect a systemic effect of depression on growing b... |
### Instruction:
Is myocardial extracellular remodeling associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis?
### Response:
| In young patients with AS, myocardial ECV is significantly elevated compared with control subjects and is associated with echocardiographic indexes of diastolic dysfunction. ECV measured by CMR may be a useful method for risk stratification and monitoring therapies targeting fibrosis. |
### Instruction:
Does activation of the PI3K/AKT pathway correlate with prognosis in stage II colon cancer?
### Response:
| Our data indicate that activation of the PI3K/AKT pathway evidenced on the protein level might be a valuable prognostic marker to stratify patients for their risk of tumour recurrence. Beside adjuvant chemotherapy targeting of upregulated PI3K/AKT signalling may be an attractive strategy for treatment of high-risk pati... |
### Instruction:
Does raman spectroscopy provide a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo?
### Response:
| Raman spectroscopy is sensitive to biochemical changes in the pregnant cervix and has high potential as a tool for detecting premature cervical remodelling in pregnant women. |
### Instruction:
Is vitamin D status independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults?
### Response:
| Serum 25(OH)D concentrations were independently associated with major plasma thiol/disulphide redox systems, suggesting that vitamin D status may be involved in redox-mediated pathophysiology. |
### Instruction:
Is the expression of TGF-β1 , Smad3 , phospho-Smad3 and Smad7 correlated with the development and invasion of nonfunctioning pituitary adenomas?
### Response:
| The activity of TGF-β signaling may be restrained in NFPAs and is correlated with the development and invasion of NFPAs. |
### Instruction:
Is ticagrelor treatment in patients with acute coronary syndrome cost-effective in Sweden and Denmark?
### Response:
| The cost per QALY of treating ACS-patients with ticagrelor compared with generic clopidogrel is below the conventional thresholds of cost-effectiveness in Sweden and Denmark. |
### Instruction:
Does atheroprotective pulsatile flow induce ubiquitin-proteasome-mediated degradation of programmed cell death 4 in endothelial cells?
### Response:
| Pulsatile shear stress induces ubiquitin-proteasome-mediated degradation of PDCD4 via a PI3K/Akt pathway in HUVECs. PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. Low PDCD4 level is associated with reduced proliferation for maintenance of HUVEC homeostasis under pulsatile shear stress. |
### Instruction:
Is obesity associated with acute inflammation in a sample of adolescents?
### Response:
| Participants with increased adiposity had higher circulating neutrophil counts, suggesting acute inflammation. Furthermore, the neutrophils showed more degranulation, indicating inflammation. Obesity-induced alteration of the adipose secretory pattern (i.e., changes in leptin levels) could be involved in acute inflamma... |
### Instruction:
Is convection-enhanced delivery of etoposide effective against murine proneural glioblastoma?
### Response:
| TOP2 is highly expressed in proneural gliomas, rendering its pharmacological targeting by intratumoral administration of etoposide by CED effective on murine proneural gliomas. We provide evidence supporting clinical testing of CED of etoposide with a molecular-based patient selection approach. |
### Instruction:
Is extensive haemorrhagic necrosis of liver an unpredictable fatal complication in dengue infection : a postmortem study?
### Response:
| Severe haemorrhagic necrosis of the liver was the cause of death in these patients probably due to direct viral infection. Predilection for severe liver disease remains unknown. Therefore, it is prudent to think beyond plasma leak as the main pathology of dengue infection and attempts should be made to develop other tr... |
### Instruction:
Is noise annoyance related to the presence of urban public transport?
### Response:
| The study has identified the presence of public transport at daytime and at night as a significant and independent predictor of high noise annoyance. Future intervention measures should concern the presence, the type and the number of public transport vehicles in order to reduce noise annoyance reactions in urban areas... |
### Instruction:
Does rapamycin limit the growth of established experimental abdominal aortic aneurysms?
### Response:
| Rapamycin limits the progression of established experimental aneurysms, increasing the translational potential of mechanistic target of rapamycin-related AAA inhibition strategies. |
### Instruction:
Does fat mass gain predict estimated GFR decline in a relatively healthy Korean population?
### Response:
| Fat mass gain over 5 years was independently associated with eGFR decline to <60 ml/min/1.73 m(2) in a relatively healthy Korean population. This finding suggests that lifestyle changes to prevent fat mass gain could be protective against the development of CKD. |
### Instruction:
Do a peer support programme for enhancing adherence to oral antipsychotic medication in consumers with schizophrenia?
### Response:
| Medication adherence may be enhanced with the addition of a peer support intervention. A problem-solving based peer support programme could be implemented in the community setting for patients who are non-adherent with oral antipsychotic medication. |
### Instruction:
Is surgical resection for local recurrence after radiofrequency ablation for colorectal liver metastasis more extensive than primary resection?
### Response:
| Surgical resection for RFA recurrence for CLM required more invasive and technically demanding procedures. Thus, RFA for CLM should be limited to unresectable cases, and patients with resectable CLM should be thoroughly advised not to undergo RFA, but rather surgical resection. |
### Instruction:
Is antibody-mediated rejection of arterialised venous allografts inhibited by immunosuppression in rats?
### Response:
| Arterialized venous allografts induce strong donor-specific anti-MHC class I and anti-MHC class II antibody production with subsequent immune-mediated destruction of these allografts with no evidence of immunoglobulin G deposition. Low-dose tacrolimus suppress the donor-specific antibody production. |
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