question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does the prostate health index selectively identify clinically significant prostate cancer?
### Response:
| The new phi test outperforms its individual components of total, free and [-2]proPSA for the identification of clinically significant prostate cancer. Phi may be useful as part of a multivariable approach to reduce prostate biopsies and over diagnosis. |
### Instruction:
Does ultrasensitive prostate specific antigen after prostatectomy reliably identify patients requiring postoperative radiotherapy?
### Response:
| Ultrasensitive prostate specific antigen 0.03 ng/ml or greater is an independent factor that identifies biochemical relapse more accurately than any traditional risk factors and confers a significant lead time advantage. This factor enables critical decisions on the timing of and indication for postoperative radiothera... |
### Instruction:
Is sleep duration during the school week associated with C-reactive protein risk groups in healthy adolescents?
### Response:
| Reduced weekday sleep duration and sleep debt were both associated with CRP Risk Group in adolescence. That these relationships may be observed prior to the onset of clinical disease suggests that adolescence may provide an opportune period for disease prevention. |
### Instruction:
Does notch1 control cell invasion and metastasis in small cell lung carcinoma cell lines?
### Response:
| Our results demonstrate that activation of Notch1 signaling pathway may represent a new strategy for treating human SCLC. |
### Instruction:
Is the early-onset preeclampsia associated with MTHFR and FVL polymorphisms?
### Response:
| MTHFR A1298C polymorphism was associated with PE. Although MTHFR C677T and FVL polymorphisms did not differ between PE patients and controls, significant differences in MTHFR A1298C, C677T and FVL polymorphisms between EOPE and LOPE/controls were observed. The synergic effect of MTHFR variants could increase PE and EOP... |
### Instruction:
Does a multistudy analysis investigating systematic differences in cardiovascular trial result between Europe and Asia?
### Response:
| This study provides some evidence that for cardiovascular interventions treatment effect estimation differs between Europe and Asia, with respect to both fatal and non-fatal end points. |
### Instruction:
Do dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer?
### Response:
| Enhanced immunogenicity of adherence dendritic cell vaccinations may be due to the presence of lymphocytes during dendritic cell culture. |
### Instruction:
Does positive allosteric modulation of the adenosine A2a receptor attenuate inflammation?
### Response:
| AEA061 increases affinity and Bmax of A2aR to adenosine, thereby increasing adenosine potency and efficacy, which translates to enhanced A2aR responsiveness. Since the A2aR negatively regulates inflammation, PAMs of the receptor offer a novel means of modulating inflammatory processes. |
### Instruction:
Is pLD3 accumulated on neuritic plaques in Alzheimer 's disease brains?
### Response:
| We identified an intense accumulation of PLD3 on neuritic plaques coexpressed with PGRN in AD brains, suggesting that PLD3 plays a key role in the pathological processes of AD. |
### Instruction:
Is the ABO blood group an independent prognostic factor in patients with resected non-small cell lung cancer?
### Response:
| The ABO blood group is an independent prognostic factor in patients with resected NSCLC. Studies of other larger cohorts are therefore needed to confirm the relationship between the ABO blood group and the prognosis among patients with resected NSCLC. |
### Instruction:
Does rectal pre-treatment with ozonized oxygen ( O3 ) aggravate clinic status in septic rats treated with amoxicillin/clavulanate?
### Response:
| Rectal pre-treatment with O3/O2 aggravates clinic status in septic rats treated with amoxicillin/clavulanate. |
### Instruction:
Does orphan nuclear receptor Nur77 inhibit Oxidized LDL-induced differentiation of RAW264.7 murine macrophage cell line into dendritic like cells?
### Response:
| These data show that GFP-Nur77 inhibited differentiation of oxLDL-treated macrophages into DC. The effects of Nur77 on the macrophage phenotype may involve changes in its subcellular distribution. |
### Instruction:
Does pioglitazone inhibit advanced glycation end product-induced TNF-α and MMP-13 expression via the antagonism of NF-κB activation in chondrocytes?
### Response:
| The PPARγ agonist pioglitazone modulates TNF-α and MMP-13 expression in cultured rabbit chondrocytes via NF-κB signaling. It indicates that pioglitazone may have therapeutic potential in OA. |
### Instruction:
Is leptin associated with mood status and metabolic homeostasis in patients with bipolar disorder?
### Response:
| Leptin is closely associated with the regulation of mood and metabolic homeostasis in patients with bipolar disorder. |
### Instruction:
Does excess visceral adiposity induce alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma?
### Response:
| This study demonstrates for the first time that ACM from viscerally-obese EAC patients elicits an altered metabolic profile and can drive mitochondrial dysfunction and altered energy metabolism in EAC cells in vitro. In vivo, in EAC patient tumors, expression of the glycolytic enzyme PKM2 is positively associated with ... |
### Instruction:
Are tumoral TP53 and/or CDKN2A alterations reliable prognostic biomarkers in patients with localized Ewing sarcoma : a report from the Children 's Oncology Group?
### Response:
| Although previous retrospective studies suggest their significance, TP53 mutation and/or CDKN2A deletion are not reliable prognostic biomarkers in localized Ewing sarcoma. |
### Instruction:
Is colonoscopy the first choice for early postoperative rectal anastomotic bleeding?
### Response:
| Anastomotic bleeding was a very rare complication after rectal cancer resection with stapled anastomosis. Colonoscopic treatment, including electrocoagulation and clipping, were both safely and effectively used in the early postoperative period to cease persistent anastomotic bleeding. |
### Instruction:
Does central corneal thickness correlate with oxygen levels in the human anterior chamber angle?
### Response:
| Physiologic correlations with central corneal thickness may provide clues to understanding why a thinner cornea increases the risk of open glaucoma. Associations between glaucoma risk, CCT, and pO2 in the AC angle suggest that exposure of the outflow system to increased oxygen or oxygen metabolites may increase oxidati... |
### Instruction:
Does hMGB1 promote a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes?
### Response:
| HMGB1 increase by fetal membrane cells in response to either oxidative stress or infection can provide a positive feedback loop generating non-infectious inflammatory activation. Activation of p38MAPK by HMGB1 promotes development of the senescence phenotype and senescence associated sterile inflammation. HMGB1 activit... |
### Instruction:
Are durability and survival similar after elective endovascular and open repair of abdominal aortic aneurysms in younger patients?
### Response:
| After elective aneurysm repair, younger patients have a moderate life expectancy related to malignant disease and cardiovascular health. EVAR offers durability and long-term survival similar to those with open repair in these younger patients as long as aneurysm anatomy and IFU are adhered to. |
### Instruction:
Is lower mean corpuscular hemoglobin concentration associated with unfavorable prognosis of resected lung cancer?
### Response:
| In conclusion, the results of this study suggest that mean corpuscular hemoglobin concentration is an independent prognostic factor for OS and RFS in non-small-cell lung cancer. |
### Instruction:
Does structural connectivity analysis reveal abnormal brain connections in agenesis of the corpus callosum in children?
### Response:
| We found reduced global and increased local connectivity in children with AgCC compared to controls. Neural plasticity in AgCC may attempt to increase the interhemispheric connectivity through alternative decussating pathways other than the corpus callosum. |
### Instruction:
Is high-dose dual therapy superior to standard first-line or rescue therapy for Helicobacter pylori infection?
### Response:
| HDDT is superior to standard regimens as empirical first-line or rescue therapy for H pylori infection, with similar safety profiles and tolerability. ClinicalTrials.gov number: NCT01163435. |
### Instruction:
Is organizational justice related to heart rate variability in white-collar workers , but not in blue-collar workers-findings from a cross-sectional study?
### Response:
| Both dimensions of organizational injustice were associated with lowered HRV among white-collar workers. The impact of justice and possibly its association with health seems to differ by occupational groups. |
### Instruction:
Is cardiomyocyte p65 nuclear factor-κB necessary for compensatory adaptation to pressure overload?
### Response:
| Rather than developing compensatory left ventricular hypertrophy, pressure overload in cardiomyocyte NF-κB-deficient mice resulted in functional deterioration that was associated with increased fibrosis, decreased hypoxia-inducible factor expression, and decreased microvessel density. These observations mechanistically... |
### Instruction:
Is unilateral chronic lung allograft dysfunction a characteristic of bilateral living-donor lobar lung transplantation?
### Response:
| Despite a relatively short observation time, CLAD developed in approximately one-fifth of the patients who survived more than 3 months after LDLLT. In bilateral LDLLT, CLAD developed unilaterally in most cases, which might be beneficial in the long term because the unaffected contralateral lung may function as a reserv... |
### Instruction:
Do concurrent effect of noise exposure and smoking on extended high-frequency pure-tone thresholds?
### Response:
| Concurrent exposure to noise and smoking may be associated with more hearing loss than exposure to noise alone in the conventional and high frequencies. However, other differences between smokers and non-smokers may explain these differences as well. |
### Instruction:
Is the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1α ( PGC-1α ) associated with type 2 diabetes in Tunisian population?
### Response:
| In the current study, a significant and independent association between the Gly482Ser polymorphism (rs8192678) of the PGC-1α gene and T2D in the Tunisian population was found. |
### Instruction:
Do clinical mesenchymal stromal cell products undergo functional changes in response to freezing?
### Response:
| High pre-freeze senescence appears to correlate with poor post-thaw function in MSC samples, but additional studies are necessary to obtain a sample sizes large enough to quantify results. |
### Instruction:
Do human CD14+ cells loaded with Paclitaxel inhibit in vitro cell proliferation of glioblastoma?
### Response:
| Our results are the first demonstration that peripheral blood-derived CD14+ and DCs, in addition to their application for immunotherapy for GB, could also be used to delivery anti-cancer drugs, such as PTX, to kill GB cells. |
### Instruction:
Does the neutralizing antibody GNbAC1 abrogate HERV-W envelope protein-mediated oligodendroglial maturation blockade?
### Response:
| Beyond immune cell modulation, this monoclonal antibody may therefore help to overcome the oligodendroglial differentiation blockade in MS. |
### Instruction:
Is corpus callosum atrophy strongly associated with cognitive impairment in multiple sclerosis : Results of a 17-year longitudinal study?
### Response:
| The nCCA correlates well with physical and cognitive disability in time perspectives close to two decades, outperforming volumetric measurements. The nCCA is fast and could be feasible for clinical implementation where it may help identify patients in need of neuropsychological evaluation. |
### Instruction:
Is two-week treatment with proton pump inhibitor sufficient for healing post endoscopic submucosal dissection ulcers?
### Response:
| Two-wk treatment with a proton pump inhibitor is as effective as four-week treatment for healing post ESD ulcers. |
### Instruction:
Does application of therapeutic harp sound for quality of life among hospitalized patients?
### Response:
| There is evidence of strong positive effects on the QOL of hospitalized patients who received therapeutic harp sound treatment along with standard care. |
### Instruction:
Is exposure to maternal gestational diabetes associated with higher cardiovascular responses to stress in adolescent indians?
### Response:
| Maternal diabetes during pregnancy is associated with higher cardiosympathetic stress responses in the offspring, which may contribute to their higher cardiovascular disease risk. Further research may confirm stress-response programming as a predictor of cardiovascular risk in OGDM. |
### Instruction:
Do protein structure prediction with local adjust tabu search algorithm?
### Response:
| Although the off-lattice models is not very realistic, they can reflect some important characteristics of the realistic protein. It can be found that 3D off-lattice model is more like native folding structure of the realistic protein than 2D off-lattice model. In addition, compared with some previous researches, the pr... |
### Instruction:
Do chilo suppressalis and Sesamia inferens display different susceptibility responses to Cry1A insecticidal proteins?
### Response:
| S. inferens exhibited a significantly lower susceptibility and more rapidly evolved resistance to Cry1A compared with C. suppressalis. Therefore, S. inferens is more likely to evolve increased resistance, which threatens the sustainability of rice expressing Cry1A protein. |
### Instruction:
Do rates and risk factors for progression to incident dementia vary by age in a population cohort?
### Response:
| Risk and protective factors were only found for incident dementia with onset before the median onset age of 87 years, and not for those with later onset. Either unexplored risk factors explain the continued increase in incidence with age, or unknown protective factors are allowing some individuals to delay onset into v... |
### Instruction:
Do olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community?
### Response:
| Impairment in odor identification was superior to deficits in verbal episodic memory in predicting cognitive decline in cognitively intact participants. The findings support the cross-cultural use of a relatively inexpensive odor identification test as an early biomarker of cognitive decline and AD dementia. Such testi... |
### Instruction:
Do stimulation intensities of transcranial direct current stimulation have to be adjusted in children and adolescents?
### Response:
| For the first time, the study demonstrates age-specific influences of tDCS on cortical excitability of the primary motor cortex. |
### Instruction:
Does muraglitazar-eluting bioabsorbable vascular stent inhibit neointimal hyperplasia in porcine iliac arteries?
### Response:
| This new muraglitazar-eluting PLA96 stent was shown to be biocompatible with a tendency for better patency and less intimal hyperplasia compared with the control PLA96 stents. |
### Instruction:
Does surfactant protein D attenuate sub-epithelial fibrosis in allergic airways disease through TGF-β?
### Response:
| These data support a protective role for SP-D in the pathogenesis of sub-epithelial fibrosis in a mouse model of allergic inflammation through regulation of eosinophil-derived TGF-β. |
### Instruction:
Is uncomplicated human type 2 diabetes associated with meal-induced blood pressure lowering and cardiac output increase?
### Response:
| Based on these data, we hypothesize that in patients with uncomplicated type 2 diabetes, insulin resistance hampers adequate meal-induced sympathetic activation, leading to a decrease in SVR and resulting in a postprandial drop in DBP. |
### Instruction:
Is cD1d expression in renal cell carcinoma associated with higher relapse rates , poorer cancer-specific and overall survival?
### Response:
| CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes. |
### Instruction:
Is elevated mean platelet volume associated with poor short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure patients?
### Response:
| MPV values at presentation were higher among nonsurvivors than survivors, and this parameter was well correlated with liver function parameters and may be used as a predictor for 4-week mortality rate in patients with HBV-ACLF. |
### Instruction:
Does blockade of CXCL12/CXCR4 signaling inhibit intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway?
### Response:
| In conclusion, our result shows that high CXCR4 expression is associated with IHCC progression and metastasis via the canonical Wnt pathway, suggesting that CXCR4 may serve as a promising therapeutic target for IHCC. |
### Instruction:
Do menstrual blood-derived stromal stem cells inhibit optimal generation and maturation of human monocyte-derived dendritic cells?
### Response:
| This is the first study to address the inhibitory impact of MenSCs on generation and maturation of DCs. IL-6 and IL-10 could be partly held responsible for this effect. Given the central roles of DCs in regulation of immune responses, these results highlight the importance of further research on the potential modulator... |
### Instruction:
Does cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 trigger prostate cancer cell proliferation?
### Response:
| We demonstrate a cross-talk between alpha1D-AR and TRPV1, that is involved in the control of PC3 cell proliferation. These data strongly support for a putative novel pharmacological approach in the treatment of PCa by targeting both alpha1D-AR and TRPV1 channels. |
### Instruction:
Do molecular and clinical analyses of 16q24.1 duplications involving FOXF1 identify an evolutionarily unstable large minisatellite?
### Response:
| Our data indicate that constitutional duplication of FOXF1 in humans is not associated with any pediatric lung abnormalities. We propose that patients with gut malrotation, pyloric or duodenal stenosis, and gall bladder agenesis should be tested for FOXF1 alterations. We suggest that instability of minisatellites great... |
### Instruction:
Do mesenchymal stem cells expressing baculovirus-engineered BMP-2 and VEGF enhance posterolateral spine fusion in a rabbit model?
### Response:
| The results indicate the potential of using baculovirus as a vector for gene/cell therapy approaches to improve bone healing and support the feasibility of using allogeneic MSCs for inducing bone formation and intertransverse process fusion. |
### Instruction:
Is diagnostic accuracy of self-reported arthritis in the general adult population acceptable?
### Response:
| The accuracy of self-reported OA and RA is acceptable for large-scale studies in which rheumatologist examination is not feasible. More high-quality studies are required to confirm the accuracy of self-reported arthritis and joint-specific OA. |
### Instruction:
Is diabetic symmetric polyneuropathy associated with increased aortal stiffening but not cerebral angiopathy in type 1 diabetes?
### Response:
| DSP is associated with systemic macroangiopathy, reflected by increased carotid-femoral PWV, but not with the cerebral macro- and microangiopathy. |
### Instruction:
Does trihelix transcription factor GT-4 mediate salt tolerance via interaction with TEM2 in Arabidopsis?
### Response:
| GT-4 interacts with TEM2 and then co-regulates the salt responsive gene Cor15A to improve salt stress tolerance. |
### Instruction:
Is statin use associated with improved survival in patients undergoing surgery for renal cell carcinoma?
### Response:
| These data suggest that statin usage at time of surgery is independently associated with improved OS and DSS in patients undergoing surgery for RCC. |
### Instruction:
Does obatoclax induce Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells?
### Response:
| In summary, Beclin 1 and ATG5 play important roles in regulating both Obatoclax-induced autophagy and apoptosis in adenoid cystic carcinoma. |
### Instruction:
Is the tag SNP rs10746463 in decay-accelerating factor associated with the susceptibility to gastric cancer?
### Response:
| DAF rs10746463 polymorphism effects on the risk of developing gastric cancer in Chinese population. |
### Instruction:
Is p16 ( INK4 ) expression associated with human papillomavirus in oral lichen planus?
### Response:
| p16(INK4) overexpression is not correlated with HPV in patients with LP. |
### Instruction:
Does mUC18 Differentially regulate Pro-Inflammatory and Anti-Viral Responses in Human Airway Epithelial Cells?
### Response:
| Our results for the first time demonstrate MUC18's pro-inflammatory and anti-viral function in human airway epithelial cells. |
### Instruction:
Is early adaptation to oxygen key to the industrially important traits of Lactococcus lactis ssp . cremoris during milk fermentation?
### Response:
| Combining metabolic and transcriptomic profiling, together with oxygen consumption kinetics, yielded new insights into the whole genome adaptation of L. lactis to initial oxidative stress. An early and transitional adaptation to oxidative stress was revealed for L. lactis subsp. cremoris MG1363 in the presence of initi... |
### Instruction:
Does leishmania donovani infection enhance lateral mobility of macrophage membrane protein which is reversed by liposomal cholesterol?
### Response:
| To our knowledge this is the first direct demonstration that LD parasites during their intracellular life cycle increases lateral mobility of membrane proteins and decreases F-actin level in infected macrophages. Such defects may contribute to ineffective intracellular signaling and other cellular functions. |
### Instruction:
Are body mass index and waist circumference independent risk factors for low vital capacity among Japanese participants of a health checkup : a single-institution cross-sectional study?
### Response:
| Our results suggest that obesity may be associated with restrictive pulmonary function and underscore the importance of maintaining ideal body weight for the prevention of restrictive pulmonary dysfunction. |
### Instruction:
Do nMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells?
### Response:
| Non-competitive NMDAR antagonists attenuate BCR and Toll-like receptor 4 (TLR4) B-cell signaling and effector function and can foster IL-10 production. Consequently, NMDAR antagonists may be useful to target B cells in autoimmune diseases or pathological systemic inflammation. The drugs' additional side effects on B ce... |
### Instruction:
Does a psychologist-led educational intervention result in a sustained reduction in neonatal intensive care unit infections?
### Response:
| This study suggests that a psychologist-led course, followed by a structured CNE can lead to a sustainable reduction in infection rates in a NICU. |
### Instruction:
Do nonopioid substance use disorders and opioid dose predict therapeutic opioid addiction?
### Response:
| This article examines TOA in patients with chronic noncancer pain undergoing long-term opioid therapy. Results suggest that patients should be screened for nonopioid substance use disorders prior to prescribing. In the absence of improvement in pain or function, there is a low threshold (∼50 mg daily opioid dose) for a... |
### Instruction:
Does iliac bone grafting of the intact glenoid improve shoulder stability with optimal graft positioning?
### Response:
| This biomechanical study confirms improved anterior glenohumeral stability after iliac crest bone graft augmentation of the anterior glenoid. The results also demonstrate the importance of bone graft position in the sagittal plane, with the ideal position determined by the direction of dislocation. |
### Instruction:
Are olfactory identification deficits at identification as ultra-high risk for psychosis associated with poor functional outcome?
### Response:
| These results suggest that impaired OI is not a good marker of the onset of psychosis and schizophrenia, but may differentiate UHR individuals who experience a poor functional outcome, regardless of transition status. |
### Instruction:
Are rheumatoid factor and anti-citrullinated protein antibody positivity , but not level , associated with increased mortality in patients with rheumatoid arthritis : results from two large independent cohorts?
### Response:
| Patients with EIA who are seropositive for both RF and ACPA have increased mortality compared to those who are single positive or seronegative. Antibody level in seropositive patients was not consistently associated with excess mortality. |
### Instruction:
Does overexpression of MicroRNA-145 promote Ascending Aortic Aneurysm Media Remodeling through TGF-β1?
### Response:
| The increased expression of microRNA-145 promotes media remodeling through TGF-b1 in the aortic aneurysm wall. |
### Instruction:
Does removal of active-fixation coronary sinus lead using a mechanical rotation extraction device?
### Response:
| As illustrated by our cases, Attain StarFix® leads implanted years ago can be extracted with the help of a mechanical extraction sheath. However, this procedure bears potential risks and should only be performed with a cardiac surgery standby. If clinicians evaluate the implantation of Attain StarFix® leads in patients... |
### Instruction:
Are perinatal conditions related to growth restriction and inflammation associated with an increased risk of bronchopulmonary dysplasia?
### Response:
| Growth restriction and inflammation increased the risk of BPD in preterm infants and prelabour preterm rupture of membranes, small for gestational age, low Apgar score or need for resuscitation should raise clinical suspicions. |
### Instruction:
Does cross-species transcriptomic analysis elucidate constitutive aryl hydrocarbon receptor activity?
### Response:
| These findings, though preliminary, present a platform for further evaluating the role of the AHR in regulation of constitutive mRNA levels and physiologic function. |
### Instruction:
Are continuous electroencephalogram patterns suggestive of eventual neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia?
### Response:
| The use of cEEG can provide prognostication information otherwise not obtainable by clinical examination. Specific cEEG patterns predicted probability of mortality for patients according to their initial rhythm of CA as a function of cardiopulmonary resuscitation time. |
### Instruction:
Does reappraisal facilitate extinction in healthy and socially anxious individuals?
### Response:
| Diagnostic status of participants was not assessed in structured clinical interviews. |
### Instruction:
Is lower plasma sodium associated with a microinflammatory state among patients with advanced chronic kidney disease?
### Response:
| Our results suggest an association between lower plasma sodium and a microinflammatory state among patients with advanced CKD. Inflammation could be an underlying confounding factor explaining the increased mortality in these patients. |
### Instruction:
Does a two year national surveillance for Aethina tumida reflect its absence in Spain?
### Response:
| The SHB free-status is shown. This epidemiological surveillance would appear to be useful to detect the possible future entry of this pathogen. |
### Instruction:
Are salivary BPIFA1 ( SPLUNC1 ) and BPIFA2 ( SPLUNC2 A ) modified by head and neck cancer radiotherapy?
### Response:
| The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer. |
### Instruction:
Are serum amylase levels decreased in Chinese non-alcoholic fatty liver disease patients?
### Response:
| Compared with NAFLD patients without MS and healthy controls, serum amylase levels were significantly lower in NAFLD patients with MS. Moreover, a relative serum amylase increase may be an independent factor of more advanced hepatic fibrosis. |
### Instruction:
Does cognitive Avoidant Coping be Associated with Higher Carotid Intima Media Thickness Among Middle-Aged Adults?
### Response:
| Findings suggest that CAV could constitute a risk factor for cardiovascular diseases with increasing age. |
### Instruction:
Does primary percutaneous coronary intervention ameliorate complete atrioventricular block complicating acute inferior myocardial infarction?
### Response:
| We conclude that primary PCI can ameliorate CAVB-complicated acute inferior STEMI, with an acceptable rate of major adverse cardiac events, and suggest that primary PCI should be the preferred reperfusion therapy in patients with CAVB complicating acute inferior myocardial infarction. |
### Instruction:
Does radiation therapy overcome adverse prognostic role of cyclooxygenase-2 expression on Reed-Sternberg cells in early Hodgkin lymphoma?
### Response:
| Cyclooxygenase-2 RS cell expression is an adverse independent prognostic factor in early HL. Radiation therapy overcomes the worse prognosis associated with COX-2 expression on RS cells, acting in a chemotherapy-independent way. Cyclooxygenase-2 RS cell expression may be useful for determining patient candidates with e... |
### Instruction:
Does genome-wide association study identify TF as a significant modifier gene of iron metabolism in HFE hemochromatosis?
### Response:
| This GWAS, the largest one performed so far in unselected HFE-associated HH (HFE-HH) patients, identified the rs3811647 polymorphism in the TF gene as the only SNP significantly associated with iron metabolism through serum transferrin and iron levels. Because these two outcomes were clearly associated with the biochem... |
### Instruction:
Do phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes?
### Response:
| HLCs from different sources are broadly comparable with unbiased proteomic evidence for faithful differentiation down the liver lineage. This current phenotype mimics human fetal rather than adult hepatocytes. |
### Instruction:
Does s-Adenosylmethionine increase circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease?
### Response:
| Excess hepatic SAMe levels disrupt VLDL assembly and features and increase circulating VLDL clearance, which will cause increased VLDL-lipid supply to tissues and might contribute to the extrahepatic complications of NAFLD. |
### Instruction:
Does alcohol directly stimulate epigenetic modifications in hepatic stellate cells?
### Response:
| Ethanol directly influences HSC transdifferentiation by stimulating global changes in chromatin structure, resulting in the increased expression of ECM proteins. The ability of alcohol to remodel the epigenome during HSC transdifferentiation provides mechanisms for it to act as a co-morbidity factor in liver disease. |
### Instruction:
Does aldehyde dedydrogenase-2 play a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy?
### Response:
| In summary, our results revealed that ALDH2 plays a beneficial role in ameliorating chronic alcohol intake-induced hepatic steatosis and inflammation through regulation of autophagy. |
### Instruction:
Is insulin-like growth factor receptor-1 overexpression associated with poor response of rectal cancers to radiotherapy?
### Response:
| IGF-1R expression level may serve as a predictive biomarker for radiosensitivity of rectal cancer before preoperative radiotherapy. |
### Instruction:
Do caries risk assessment in schoolchildren -- a form based on Cariogram software?
### Response:
| The use of the form based on the Cariogram software enabled classification of the schoolchildren at low, moderate and high caries risk. Caries experience, oral hygiene, frequency of food consumption, sugar consumption and fluoride sources are the variables that were shown to be highly correlated with caries risk. |
### Instruction:
Do clinical findings provide criteria to evaluate priorities of ophthalmologic intervention in conscious multiple trauma patients?
### Response:
| The ability of an emergency physician or general surgeon to determine the actual need of early ophthalmologist intervention can improve decision making and saving both time and money. Our study suggests that it is possible to determine according to clinical findings the need of the patient to have ophthalmologic interv... |
### Instruction:
Does labor inhibit placental mechanistic target of rapamycin complex 1 signaling?
### Response:
| Several placental signaling pathways are affected by labor, which has implications for experimental design in studies of placental signaling. Inhibition of placental mTORC1 signaling in response to labor may serve to down-regulate protein synthesis and amino acid transport, processes that account for a large share of p... |
### Instruction:
Is thiobarbituric acid reactive substances ( TBARS ) a state biomarker of oxidative stress in bipolar patients in a manic phase?
### Response:
| Our sample size was limited. |
### Instruction:
Does cognitive and family correlate of current suicidal ideation in children with bipolar disorder?
### Response:
| Limitations include the small sample to examine low base-rate severe ideation, cross-sectional analyses and generalizability of findings beyond the outpatient clinical sample. |
### Instruction:
Is preoperative hypofibrinogenemia associated with increased intraoperative bleeding in ruptured abdominal aortic aneurysms?
### Response:
| Low preoperative fibrinogen concentration was significantly associated with preoperative hypotension and increased intraoperative bleeding in patients with rAAA. Patients in hemodynamic shock with blood pressure <70 mmHg had an associated fibrinogen concentration of less than 1.5 g/L. A fibrinogen concentration less th... |
### Instruction:
Are small volume of the posterior cranial fossa and arterial hypertension risk factors of hemifacial spasm?
### Response:
| There was no significant difference in VPCF and in frequency of AH diagnosis in HFS patients and age- and sex-related controls, but the logistic regression analysis showed that small VPCF and AH duration are risk factors of HFS in younger and older patients respectively. |
### Instruction:
Does intravenous amiodarone homogeneously prolong ventricular repolarization in patients with life-threatening ventricular tachyarrhythmia?
### Response:
| Iv-Amio homogeneously prolongs repolarization and properly inhibits original VT/VF recurrence without inducing torsade de pointes. |
### Instruction:
Do plaque reduction efficacy of an oscillating-rotating power brush with a novel brush head utilizing angled bristle tufts?
### Response:
| The oscillating-rotating brush with the novel brush head produced reductions in whole mouth and interproximal plaque more than twice that of the manual toothbrush. |
### Instruction:
Are mothers ' restrictive eating and food neophobia and fathers ' dietary quality associated with breast-feeding duration and introduction of solid foods : the STEPS study?
### Response:
| Mothers' and fathers' eating patterns and practices are associated with the feeding practices of infants and young children. Health promotion interventions seeking to improve parents' eating patterns might lead to more favourable feeding practices for infants and young children. |
### Instruction:
Does simulation training improve resident performance in hand-sewn vascular and bowel anastomoses?
### Response:
| After simulation-based training, residents performed vascular and bowel anastomoses more adeptly, quickly, and with a higher quality end product. Laboratory training can effectively improve residents' ability to perform anastomoses, which may result in increased efficiency of teaching in the operating room. |
### Instruction:
Do many respiratory viruses have temporal association with meningococcal disease?
### Response:
| The rate of MNG in Chile is temporally associated to all of the respiratory viruses studied, but with variability according age range, and regions. |
### Instruction:
Do diabetic patients have increased perioperative cardiac risk in heart-type fatty acid-binding protein-based assessment?
### Response:
| The H-FABP levels significantly increased in the postoperative period. Most patients with increased postoperative H-FABP levels were diabetic. High H-FABP levels could alert clinicians to increased perioperative cardiovascular risk and could prevent underdiagnosis, especially in diabetic patients. |
### Instruction:
Does down-regulated non-coding RNA ( lncRNA-ANCR ) promote osteogenic differentiation of periodontal ligament stem cells?
### Response:
| These results indicated that ANCR was a key regulator of the proliferation and osteogenic differentiation of PDLSCs, and its regulating effects was associated with the canonical WNT signalling pathway, thus offering a new target for oral stem cell differentiation studies that could also facilitate oral tissue engineeri... |
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