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### Instruction:
Does neuropeptide FF attenuate RANKL-induced differentiation of macrophage-like cells into osteoclast-like cells?
### Response:
| Our findings showed that NPFF could attenuate osteoclast-like cells differentiation in an in vitro osteoclastogenesis model. |
### Instruction:
Do rNA-seq and high-definition mass spectrometry reveal the complex and divergent venoms of two rear-fanged colubrid snakes?
### Response:
| Despite the difficulty of procuring venom from rear-fanged species, we were able to complete all analyses from a single specimen of each species without pooling venom samples or glands, demonstrating the power of high-definition transcriptomic and proteomic approaches. We found a high level of divergence in the venom t... |
### Instruction:
Does specific inhibition of the nuclear exporter exportin-1 attenuate kidney cancer growth?
### Response:
| The orally-available XPO1 inhibitor, KPT-330, represents a novel target for RCC whose in vivo efficacy approaches that of sunitinib. In addition, cells resistant to KPT-330 retain their ability to respond to available RCC therapeutics suggesting a novel approach for treatment in KPT-330-naïve as well as -resistant RCC ... |
### Instruction:
Are people with tuberculosis associated with a subsequent risk of depression?
### Response:
| People who have been diagnosed with TB have a significantly higher risk of developing depression compared with those in the general population. We should pay more attention to this group of individuals and ensure that they are offered appropriate support. |
### Instruction:
Does sorafenib inhibit macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion?
### Response:
| Sorafenib alters macrophage polarization, reduces IGF-1-driven cancer growth in vitro and partially inhibits macrophage activation in vivo. Thus macrophage modulation might contribute to the anti-cancer activity of sorafenib. However, more efficient macrophage-directed therapies are required. |
### Instruction:
Do hepatitis C virus variants resistant to macrocyclic NS3-4A inhibitors subvert IFN-β induction by efficient MAVS cleavage?
### Response:
| Our data constitutes a proof of concept that the selection of RAVs against specific classes of direct antivirals can lead to the predominance of viral variants with possibly adverse pathogenic characteristics. |
### Instruction:
Does 24-nor-ursodeoxycholic acid ameliorate inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis?
### Response:
| This study demonstrates pronounced anti-inflammatory and anti-fibrotic effects of norUDCA compared to UDCA in S. mansoni induced liver injury, and indicates that norUDCA directly represses antigen presentation of antigen presenting cells and subsequent T-cell activation in vitro. Therefore, norUDCA represents a promisi... |
### Instruction:
Does the molecular biology of the olive fly come of age?
### Response:
| Several years of molecular studies on the olive fly can now be combined with new information from whole transcriptome analyses and lead to a deep understanding of the biology of this notorious insect pest. This is a prerequisite for the development of novel embryonic lethality female sexing strains for successful SIT e... |
### Instruction:
Does school food reduce household income disparities in adolescents ' frequency of fruit and vegetable intake?
### Response:
| School food may mitigate income disparities in adolescent FVI. The findings suggest that the school food environment positively influences FVI among low-income adolescents. |
### Instruction:
Are sitting-height measures related to body mass index and blood pressure levels in children?
### Response:
| Measures of SH are strongly associated with BMI and BP in children, although the association between SH and BP is probably dependent on the association of both those variables with BMI. This is (an) important information for correct interpretation of SH values in children. |
### Instruction:
Does transcriptomic analysis of grape ( Vitis vinifera L. ) leave after exposure to ultraviolet C irradiation?
### Response:
| UV-C irridiation has an important role in some biology processes, especially cell rescue, protein fate, secondary metabolism, and regulation of transcription.These results opened up ways of exploring the molecular mechanisms underlying the effects of UV-C irradiation on grape leaves and have great implications for furt... |
### Instruction:
Does excitability of the primary motor cortex increase more strongly with slow- than with normal-speed presentation of actions?
### Response:
| These results indicate that the excitability of M1 was higher when the observed action was played at low speed. Our findings suggest that the action observation system became more active when the subjects observed the video clip at low speed, because the subjects could then recognize the elements of action and intentio... |
### Instruction:
Are circulating IGFBP-2 levels incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides?
### Response:
| In our cohort, IGFBP-2 levels <221.5 ng/mL are incrementally associated with a detrimental plasma lipoprotein-lipid profile. After adjustment for covariates, IGFBP-2 remained independently associated with VLDL-TG but not HDL-C levels. This study supports further investigations in other populations and validation of IGF... |
### Instruction:
Are a lipid-poor plaque and asymptomatic status in women associated with higher peak systolic velocity on duplex ultrasound after carotid endarterectomy?
### Response:
| Dissection of a lipid-poor plaque showed an independent association with higher PSVs in the internal carotid artery 3 months after CEA, not after mid-term follow-up. In women, significantly higher PSVs were found after midterm follow-up, especially if they were asymptomatic. |
### Instruction:
Is cyclin D1 a strong prognostic factor for survival in pancreatic cancer : analysis of CD G870A polymorphism , FISH and immunohistochemistry?
### Response:
| A strong impact on survival of Cyclin D1 G870A polymorphism and the detected corresponding protein expression was found. The biological mechanism of CCND1 in carcinogenesis has not been fully examined; but at present Cyclin D1 seems to be an interesting biomarker for the prognosis of ductal adenocarcinoma. |
### Instruction:
Are arterial tissue and plasma concentration of enzymatic-driven oxysterols associated with severe peripheral atherosclerotic disease and systemic inflammatory activity?
### Response:
| Arterial intima accumulation of 27-HC and 24S-HC is associated with advanced atherosclerotic disease and systemic inflammatory activity in individuals with severe PAD. |
### Instruction:
Does alpha-lipoic acid activate eNOS through activation of PI3-kinase/Akt signaling pathway?
### Response:
| LA activates eNOS through a PI3-kinase/Akt signaling pathway-dependent mechanism, offering a potential molecular basis for the therapeutic effects of LA on cardiovascular diseases. |
### Instruction:
Is digoxin treatment associated with increased total and cardiovascular mortality in anticoagulated patients with atrial fibrillation?
### Response:
| In AF patients on good anticoagulation control with VKAs, digoxin use was associated with a higher rate of total and CV mortality. |
### Instruction:
Does a newly-developed metal artifact reduction algorithm improve the visibility of oral cavity lesions on 320-MDCT volume scans?
### Response:
| The SEMAR algorithm reduces dental metal artifacts and improves lesion detectability and image quality in patients with oral cavity lesions. |
### Instruction:
Is severe thinness associated with mortality in patients with community-acquired pneumonia : a prospective observational study?
### Response:
| Severe thinness (BMI<16 kg/m2) was associated with 30-day mortality in patients with CAP, showing improved prognostic performance when combined with PSI. We propose that physicians consider a patient's nutritional state using BMI when predicting mortality in CAP. |
### Instruction:
Does rP105 deficiency attenuate early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner?
### Response:
| We here show that RP105 deficiency results in reduced early atherosclerotic plaque development with a marked decrease in lesional macrophage content, which may be due to disturbed migration of RP105 deficient monocytes resulting from CCR2 downregulation. |
### Instruction:
Is protection of CpG islands against de novo DNA methylation during oogenesis associated with the recognition site of E2f1 and E2f2?
### Response:
| Our results support a DNA sequence-independent and transcription-driven model of de novo CGI methylation during oogenesis. In contrast, our results for CGIs that remain unmethylated are consistent with a model of protection from methylation involving sequence recognition by DNA-binding proteins, E2f1 and E2f2 being pro... |
### Instruction:
Are differentially charged isoforms of apolipoprotein E from human blood potential biomarkers of Alzheimer 's disease?
### Response:
| The isoelectric distribution of differentially charged ApoE isoforms was used to determine the presence of AD in a small group of samples. Further studies are needed to validate their use as predictors of disease onset and progression, and as biomarkers for determining the efficacy of therapeutic treatments. |
### Instruction:
Do low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment?
### Response:
| Our study confirms a lack of suitability of CSF C3 and FH as diagnostic biomarkers of AD, but points to their modest potential as prognostic biomarkers and therapeutic targets in cognitively impaired patients. |
### Instruction:
Is the effect of galantamine on brain atrophy rate in subjects with mild cognitive impairment modified by apolipoprotein E genotype : post-hoc analysis of data from a randomized controlled trial?
### Response:
| Patients with MCI who were treated with galantamine demonstrated a lower rate of whole brain atrophy, but not of hippocampal atrophy, over a 24-month treatment period, compared to those treated with placebo. This protective effect of galantamine on whole brain atrophy rate in MCI was only present in APOE ϵ4 carriers. |
### Instruction:
Are inflammatory scores interchangeable during the perioperative period of breast cancer surgery?
### Response:
| Inflammatory biomarkers and scores, like CRP, WBCs, N, NLR, PNI, and PI are modified after a breast cancer surgery, but with discordance and no interchangeability. |
### Instruction:
Are second Toe Systolic Pressure Measurements Valid Substitutes for First Toe Systolic Pressure Measurements in Diabetic Patients : A Prospective Study?
### Response:
| This is the first study which demonstrates that second toe systolic pressures are interchangeable with those of the first toe. Second toe pressures can be used in diabetic patients whose first toe pressures cannot be assessed. |
### Instruction:
Does a clinical study relating CIELCH coordinate to the color dimensions of the 3D-Master System in a Spanish population?
### Response:
| Despite the limitations of this study, the 3D-Master System was found to be arranged according to L*, C*, and h* coordinates in groups of lightness, chroma, and hue. The corresponding groups of lightness, chroma, and hue can be estimated on the basis of L*, C*, and h* coordinates. |
### Instruction:
Does etanercept ameliorate inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis?
### Response:
| We established a novel multi-flare SCW arthritis model enabling drug intervention in different stages of disease. We show for the first time the evaluation of inflammation and pain simultaneously in this model. Etanercept and Dexamethasone inhibited inflammation, pain and proinflammatory cytokines in this model. Taken ... |
### Instruction:
Does proton pump inhibitor therapy increase the incidence of spontaneous bacterial peritonitis in cirrhosis : a multicenter prospective study?
### Response:
| In the current large, multicenter, prospective study, PPI therapy, specifically evaluated at admission of consecutive cirrhotic patients, was not associated with a higher risk of SBP. |
### Instruction:
Does the spliceosome factor SART1 exert its anti-HCV action through mRNA splicing?
### Response:
| The spliceosome factor SART1 is not IFN-inducible but is an IEG. SART1 exerts its anti-HCV action through direct transcriptional regulation for some ISGs and alternative splicing for others, including EIF4G3, GORASP2. SART1 does not have an effect on IFN receptor or canonical signal transduction components. Thus, SART1... |
### Instruction:
Does next generation sequencing read comparison with an alignment-free distance?
### Response:
| Alignment-free distances may be used effectively for reads comparison, and may provide a significant speed-up in several processes based on NGS sequencing (e.g., DNA assembly, reads classification). |
### Instruction:
Is serum indoleamine 2,3-dioxygenase activity associated with reduced immunogenicity following vaccination with MVA85A?
### Response:
| Baseline IDO activity was higher in South African volunteers when compared to UK volunteers, which may represent a potential mechanism for the observed variation in vaccine immunogenicity in South African and UK populations and may have important implications for future vaccination strategies. |
### Instruction:
Do epitope-focused peptide immunogens in human use adjuvants protect rabbits from experimental inhalation anthrax?
### Response:
| An LND-specific epitope-focused vaccine may complement PA-based vaccines and may represent a complementary stand-alone vaccine for anthrax. |
### Instruction:
Is human fetal ventricular cardiomyocyte , RL-14 cell line , a promising model to study drug metabolizing enzymes and their associated arachidonic acid metabolites?
### Response:
| The current study provides the first evidence that RL-14 cells express CYP isoenzymes at comparable levels to those expressed in the primary cells and thus offers a unique in vitro model to study DMEs in the heart. |
### Instruction:
Is hDL size more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk?
### Response:
| The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR. |
### Instruction:
Does restrictive reporting of selected antimicrobial susceptibilities influence clinical prescribing?
### Response:
| Selective reporting helps physicians choose the most appropriate antibiotics for their patients within a stewardship program, with reduced C. difficile infection. |
### Instruction:
Do anxiety sensitivity and expectation of arousal differentially affect the respiratory response to caffeine?
### Response:
| The results highlight the modulating role of expectancies in respiratory responding to caffeine in low vs. high anxiety sensitive persons and might have important implications for the better understanding of unexpected panic attacks. |
### Instruction:
Does persistence of pulmonary hypertension by echocardiography predict short-term outcomes in congenital diaphragmatic hernia?
### Response:
| The majority of infants with CDH resolve PH between 1 and 3 weeks of life. At 2 weeks of age, severity of PH by echocardiogram strongly predicts short-term pulmonary morbidity and death. Further evaluation of physiological alterations during that time may lead to novel therapies for severe CDH. |
### Instruction:
Does leading-process actomyosin coordinate organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons?
### Response:
| We propose that actomyosin coordinates the overall polarity of migrating CGNs by controlling asymmetric organelle positioning and cell-cell contacts as these cells move along their glial guides. |
### Instruction:
Does slow cooling protocol improve fatigue life of zirconia crowns?
### Response:
| Improved fatigue life in tandem with the absence of porcelain fractures were observed in slow cooled crowns, regardless of framework design. Crowns fast cooled chiefly failed by porcelain cohesive fractures. |
### Instruction:
Does microRNA-144 suppress cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b?
### Response:
| Our results showed that miR-144 was reduced in CCA tissues and suggested that miR-144 may be an essential suppresser of CCA cell proliferation and invasion through targeting LIS1. |
### Instruction:
Does bAG3 protect against hyperthermic stress by modulating NF-κB and ERK activities in human retinoblastoma cells?
### Response:
| The silencing of BAG3 seems to enhance the effects of HT, at least in part, by maintaining HT-induced inactivity of NF-κB and the phosphorylation of ERK. These findings indicate that BAG3 may be a potential molecular target for modifying the outcomes of HT in retinoblastoma. |
### Instruction:
Does emiliania huxleyi endure N-limitation with an efficient metabolic budgeting and effective ATP synthesis?
### Response:
| The use of the ornithine-urea cycle to budget the cellular nitrogen in situations of limitation resembles the responses observed earlier in diatoms. This suggests that underlying biochemical mechanisms are conserved among distant clades of marine phototrophic protists. The ornithine-urea cycle and proline oxidation app... |
### Instruction:
Does structural MRI correlate of the MMSE and pentagon copying test in Parkinson 's disease?
### Response:
| Our results suggest MMSE and the pentagon item reflect brain changes which at a regional level involve mainly posterior regions. Correlates of the pentagon item were seen in the same regions where PD patients exhibited significant thinning, and involved more areas and bigger cluster sizes than the correlates of MMSE gl... |
### Instruction:
Is metabolic syndrome associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation?
### Response:
| MS is associated with a higher recurrence rate of outflow tract PVCs after CA in patients without structural heart disease. |
### Instruction:
Does airflow accelerate bovine and human articular cartilage drying and chondrocyte death?
### Response:
| Airflow significantly increased articular cartilage dehydration and chondrocyte death compared to static air. As laminar airflow is routinely utilised in operating theatres, it is essential that articular cartilage is kept wet via irrigation or by covering with saline-saturated gauze to prevent chondrocyte death. |
### Instruction:
Do mitochondrial proteases act on STARD3 to activate progesterone synthesis in human syncytiotrophoblast?
### Response:
| Metalloproteases from human placental mitochondria are involved in steroidogenesis through the proteolytic activation of STARD3. 1,10-Phenanthroline inhibits STARD3 proteolytic cleavage. The 28-kDa protein and the amino terminal truncated-STARD3 stimulate steroidogenesis in a comparable rate, suggesting that both prote... |
### Instruction:
Is growth and metastasis of B16-F10 melanoma cells critically dependent on host CD73 expression in mice?
### Response:
| CD73 expression on host cells, particularly on endothelial and hematopoietic cells, does not modulate tumor growth and metastatic spread of B16-F10 melanoma cells most likely because of insufficient adenosine formation by the tumor itself. |
### Instruction:
Do development of piperic acid derivatives from Piper nigrum as UV protection agents?
### Response:
| From the results, isopropyl piperate is an outstanding compound that can be developed into a UV protection agent. |
### Instruction:
Does combination of MiR-103a-3p and mesothelin improve the biomarker performance of malignant mesothelioma diagnosis?
### Response:
| The results of this study show that the combination of mesothelin and miR-103a-3p improves the diagnostic performance of individual blood-based biomarker to detect malignant mesothelioma. The obtained results indicate that the use of biomarkers of different molecular classes might be a reasonable approach to assemble a... |
### Instruction:
Do time Seeing a Hand Surgeon Is Not Associated With Patient Satisfaction?
### Response:
| Patient satisfaction among patients undergoing hand surgery may relate more to shorter time in the waiting room and to the quality more than the quantity of time spent with the patient. |
### Instruction:
Does most American Academy of Orthopaedic Surgeons ' online patient education material exceed average patient reading level?
### Response:
| Most of the online patient education materials from the AAOS had readability levels that are far too advanced for many patients to comprehend. Efforts to adjust the readability of online education materials to the needs of the audience may improve the health literacy of orthopaedic patients. Patient education materials... |
### Instruction:
Is residual deformity the most common reason for revision hip arthroscopy : a three-dimensional CT study?
### Response:
| We found marked radiographic evidence of incomplete correction of deformity in patients with residual symptoms compared with patients with successful results with residual deformity present in the large majority of patients (45 of 50 [90%]) undergoing residual FAI surgery. We recommend careful attention to full 3-D res... |
### Instruction:
Is upregulation of microRNA-106b associated with poor prognosis in hepatocellular carcinoma?
### Response:
| Our data indicated that miR-106b expression was significantly upregulated in HCC and could serve as a potential unfavorable prognostic biomarker. |
### Instruction:
Does hypothermia treatment preserve mitochondrial integrity and viability of cardiomyocytes after ischaemic reperfusion injury?
### Response:
| Hypothermia treatment at 31 °C can ameliorate cardiomyocyte damage caused by simulated ischaemic reperfusion injuries. Mitochondrial calcium homeostasis, energy metabolism, and membrane integrity are preserved and play critical roles during therapeutic hypothermia treatment. |
### Instruction:
Does reproductive knowledge and patient education need among Indonesian women infertility patients attending three fertility clinics?
### Response:
| The study revealed the need for expanded infertility patient education among women patients accessing fertility care in Indonesian clinics. |
### Instruction:
Is the high-temperature requirement factor A3 ( HtrA3 ) associated with acquisition of the invasive phenotype in oral squamous cell carcinoma cells?
### Response:
| The findings of this study demonstrated that the HtrA3 is likely to be associated with the acquisition of the invasive phenotype in oral squamous cell carcinoma cells and may be a potential prognostic marker for oral cancer. |
### Instruction:
Is autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model directed against multiple autoantigens?
### Response:
| Development of AIH in APS-1 is dependent on specific Aire mutations and genetic background genes. Autoimmune response is polyspecific and can be controlled by steroids or transfer with Tregs. This might enable new treatment options for patients with AIH. |
### Instruction:
Do predictors of buprenorphine initial outpatient maintenance and dose taper response among non-treatment-seeking heroin dependent volunteers?
### Response:
| Number of prior heroin quit attempts may predict BUP dose taper response and provide a metric for stratifying heroin-dependent individuals by relative risk for opioid lapse. This metric may inform personalized relapse prevention care and improve treatment outcomes. |
### Instruction:
Does a comparison of supine and prone positioning on improve arterial oxygenation in premature neonates?
### Response:
| These findings suggest that, in premature infants with RDS, oxygen saturation was significantly higher in the prone compared with the supine posture. |
### Instruction:
Does microRNA-495 regulate the proliferation and apoptosis of human umbilical vein endothelial cells by targeting chemokine CCL2?
### Response:
| MiR-495 could affect HUVECs proliferation and apoptosis by directly targeting CCL2. This is the first report to disclose the roles and mechanisms of miR-495 on HUVECs proliferation and apoptosis, which may provide a theoretical basis for clarifying the mechanisms of atherosclerosis. |
### Instruction:
Does brief provider communication skills training fail to impact patient hypertension outcomes?
### Response:
| The intervention did not improve the outcomes; it may have been too brief and lacked sufficient practice level changes to impact counseling, adherence or BP. |
### Instruction:
Is noncoronary inflammation in Kawasaki disease associated with abnormal myocardial deformation in the acute phase?
### Response:
| Patients presenting with KD with MR or PE at diagnosis are likely to have altered ventricular mechanics compared with patients with KD without MR or PE despite normal conventional echocardiographic measures of function. There is no significant difference in ventricular mechanics when comparing patients with KD with cor... |
### Instruction:
Do mesenchymal stem cell spheroids exhibit enhanced in-vitro and in-vivo osteoregenerative potential?
### Response:
| Our in-vitro and in-vivo results reveal that MSCs in the spheroid culture exhibit enhanced osteoregenerative efficiency compared with monolayer MSCs. |
### Instruction:
Do residual arrhythmogenic foci predict recurrence in long-standing persistent atrial fibrillation patients after sinus rhythm restoration ablation?
### Response:
| Residual AMF are associated with an increased long-term AF recurrence after sinus rhythm restoration ablation for long-standing persistent AF. |
### Instruction:
Are mental stress in atopic dermatitis -- neuronal plasticity and the cholinergic system affected in atopic dermatitis and in response to acute experimental mental stress in a randomized controlled pilot study?
### Response:
| In humans chronic inflammatory and highly acute psycho-emotional stress interact to modulate cutaneous neuro-immune communication and NNCS marker expression. These findings may have consequences for understanding and treatment of chronic inflammatory diseases in the future. |
### Instruction:
Is modulation of tumor fatty acids , through overexpression or loss of thyroid hormone responsive protein spot 14 associated with altered growth and metastasis?
### Response:
| This study demonstrates a potential role for S14 in regulating mammary tumor growth and fatty acid synthesis in vivo. Furthermore, these results suggest that modulating the amount of medium chain fatty acids, by changing the levels of S14, has the potential to impact malignant mammary tumor phenotypes. |
### Instruction:
Is nonspecific abdominal pain a safe diagnosis?
### Response:
| This study confirms that a clinical diagnosis of nonspecific abdominal pain (NSAP) is safe in a pediatric population and the risk of "missing" appendicitis is only 0.2%. Patients and/or parents can be confidently reassured that the risk of missing organic pathology is very low. |
### Instruction:
Does inhibition of autophagy recover cardiac dysfunction and atrophy in response to tail-suspension?
### Response:
| Our studies hint that the components of the autophagy-related signaling pathway are potential therapeutic targets for the treatment of cardiac diseases induced by physical inactivity. |
### Instruction:
Is neurobeachin required postsynaptically for electrical and chemical synapse formation?
### Response:
| Our data identify a surprising link between electrical and chemical synapse formation and show that Nbea acts as a critical regulator in the postsynaptic neuron for the coordination of dendritic morphology with synaptogenesis. |
### Instruction:
Does preliminary whole-exome sequencing reveal mutations that imply common tumorigenicity pathways in multiple endocrine neoplasia type 1 patients?
### Response:
| Whole-exome sequencing revealed somatic mutations in MEN1 associated with a single tumorigenic network, whereas sporadic pathogenesis seemed to be more diverse. A somatic TP53 mutation was also identified. LOH of chromosome 11 was seen in all MEN1 and 3 of 10 sporadic patients. |
### Instruction:
Is absolute lymphocyte count at day 29 of treatment a powerful predictor of outcome in multiple myeloma?
### Response:
| We concluded that the ALC-29 is a useful and simple predictor of outcome in newly diagnosed MM patients who receive standard chemotherapy. Our results support the hypothesis that host immunity plays an important role in tumor control in MM. |
### Instruction:
Is loss of heterozygosity of PTEN ( encoding phosphate and tensin homolog ) associated with elevated HER2 expression an adverse prognostic indicator in gastric cancer?
### Response:
| Although HER2 expression itself was not a prognostic factor, the combination of HER2 expression and LOH of PTEN exacerbates the malignant potential of gastric cancer through its proliferative function. |
### Instruction:
Does delayed otolaryngology referral for voice disorders increase health care costs?
### Response:
| Increased time from first primary care to first otolaryngology evaluation is associated with increased outpatient health care costs. Earlier otolaryngology examination may reduce health care expenditures in the evaluation and management of patients with laryngeal/voice disorders. |
### Instruction:
Does pre-hospital dietary intake correlate with muscle mass at the time of fracture in older hip-fractured patients?
### Response:
| A low intake of calories, protein, and leucine is associated with reduced muscle mass in hip-fractured elderly. Given the relevance of sarcopenia as a risk factor for adverse outcomes in this patient population, our findings highlight the importance of a comprehensive dietary assessment for the detection of nutritional... |
### Instruction:
Is trehalose a versatile and long-lived chaperone for desiccation tolerance?
### Response:
| Our results suggest that trehalose is both a more stable and more versatile protectant than protein chaperones, explaining its important role in desiccation tolerance and emphasizing the translational potential of small chemical chaperones as stress effectors. |
### Instruction:
Does activation of Foxo1 by insulin resistance promote cardiac dysfunction and β-myosin heavy chain gene expression?
### Response:
| Our study suggests that Foxo1 has important roles in promoting diabetic cardiomyopathy and controls β-MHC expression in the development of cardiac dysfunction. Targeting Foxo1 and its regulation will provide novel strategies in preventing metabolic and myocardial dysfunction and influencing MHC plasticity in diabetes m... |
### Instruction:
Does arcuate fasciculus laterality by diffusion tensor imaging correlate with language laterality by functional MRI in preadolescent children?
### Response:
| Like fMRI, DTI also reveals language laterality in children with a high degree of correlation between the two imaging modalities. |
### Instruction:
Is intussusception associated with the detection of adenovirus C , enterovirus B and rotavirus in a rotavirus vaccinated population?
### Response:
| Our results show that intussusception is associated with non-enteric adenovirus infections, and Enterovirus B infections. While a statistical association was seen with rotavirus and intussusception, we were not able to determine if this was related to vaccine strain or wild type rotavirus. |
### Instruction:
Does tomato nuclear proteome reveal the involvement of specific E2 ubiquitin-conjugating enzymes in fruit ripening?
### Response:
| Our results uncover a novel function of protein ubiquitination, identifying specific E2s as regulators of fruit ripening. These findings contribute to the unraveling of the gene regulatory networks that control fruit ripening. |
### Instruction:
Is maximum walking speed a key determinant of long distance walking function after stroke?
### Response:
| For individuals in the chronic phase of stroke recovery, improving maximum walking speed may be necessary to improve long-distance walking function. |
### Instruction:
Are negative symptoms associated with lower autonomous motivation towards physical activity in people with schizophrenia?
### Response:
| These findings provide evidence that negative symptoms are associated with lower autonomous motivation towards physical activity in inpatients with schizophrenia. Future longitudinal research should confirm the current findings. Such research will guide physical activity approaches aimed at facilitating enhanced physic... |
### Instruction:
Is c-FLIP involved in tumor progression of peripheral T-cell lymphoma and targeted by histone deacetylase inhibitors?
### Response:
| c-FLIP overexpression in PTCLs protected tumor cells from extrinsic apoptosis and contributed to tumor progression. Although linking to chemoresistance, c-FLIP indicated tumor cell sensitivity to HDACIs, providing a potential biomarker of targeting apoptosis in treating PTCLs. |
### Instruction:
Is routine coagulation screening an unnecessary step prior to ERCP in patients without biochemical evidence of jaundice : a cross-centre study?
### Response:
| Normal pre-ERCP bilirubin was 99.7% (98.5-100) sensitive to predict a PT <16.8 s. Cost savings of £14,350 could have been achieved with judicial use of coagulation screening. |
### Instruction:
Does pregnancy affect morphology of induced endometriotic lesions in a mouse model through alteration of proliferation and angiogenesis?
### Response:
| These challenging results provide insight in understanding the pathophysiology of endometriosis and evoke a correlation between lesion architecture and symptomatology. |
### Instruction:
Is viability of cumulus cells associated with basal AMH levels in assisted reproduction?
### Response:
| For the first time it could be shown that in fact clinical embryologists deal with two different entities of cumulus cells, inner and outer ones. It seems that any protective mechanism of the female gamete follows an outward gradient, so that negative effects, e.g. apoptosis, may impair outer cumulus cells first. Age-c... |
### Instruction:
Is multimodal pain control associated with reduced hospital stay following open abdominal hysterectomy?
### Response:
| Multimodal pain control is associated with significantly reduced hospital stay after open abdominal hysterectomy. |
### Instruction:
Does a nuclear factor kappa B-derived inhibitor tripeptide inhibit UVB-induced photoaging process?
### Response:
| Results showed NF-κB-DVH had strong anti-inflammatory activity probably by inhibiting NF-κB activation pathway and suggested to be used as a novel agent for anti-photoaging. |
### Instruction:
Does iL-6 regulate stress-induced REX-1 expression via ATP-P2Y1 signalling in stem cells isolated from human exfoliated deciduous teeth?
### Response:
| ATP-P2Y1 signalling is involved in IL-6-regulated stress-induced REX-1 expression in SHEDs. These results imply the participation of mechanical stress, IL-6, and ATP in regulating the expression of REX-1, a pluripotent stem cell marker. |
### Instruction:
Does mDA5 play a critical role in interferon response during hepatitis C virus infection?
### Response:
| Our data demonstrate that MDA5 recognizes HCV to initiate host innate immune response during HCV infection. This study provides insight into how host senses HCV to initiate innate immunity during HCV infection. |
### Instruction:
Does resolution of liver fibrosis require myeloid cell-driven sinusoidal angiogenesis?
### Response:
| We identify myeloid cell-derived VEGF as a critical regulator of extracellular matrix degradation by liver endothelial cells, thereby unmasking an unanticipated link between angiogenesis and the resolution of fibrosis. |
### Instruction:
Does hepatitis C virus infection inhibit P-body granule formation in human livers?
### Response:
| This is the first comprehensive in vivo P-body analysis that links a pathogenic condition to P-body alterations. Because of their role in gene expression, the alteration of P-bodies should be further studied to understand fully complex HCV-associated pathologies. |
### Instruction:
Do interstitial 7q31.1 copy number variations disrupting IMMP2L gene are associated with a wide spectrum of neurodevelopmental disorders?
### Response:
| IMMP2L encodes an inner mitochondrial membrane protease-like protein, which is required for processing of cytochromes inside mitochondria. Numerous studies reported that this gene is implicated in behavioural disorders such as autistic spectrum disorders, attention-deficit hyperactivity disorders, and Gilles de la Tour... |
### Instruction:
Are kallikrein family proteases KLK6 and KLK7 potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes?
### Response:
| KLK6 and KLK7 mRNA and protein overexpression is directly associated with early-stage ovarian tumors and can be measured in patient tissue and serum samples. Assays based on KLK6 and KLK7 expression may provide specific and sensitive information for early detection of ovarian cancer. |
### Instruction:
Is adverse vascular risk related to cognitive decline in older adults?
### Response:
| An adverse vascular risk profile is associated with worse cognitive trajectory, especially global cognition, naming, and information processing speed, among NC elders. Future studies are needed to understand how effective management of CVD and related risk factors can modify cognitive decline to identify the ideal time... |
### Instruction:
Are epigenetic modifications associated with inter-species gene expression variation in primates?
### Response:
| Our observations suggest that epigenetic modifications are substantially associated with changes in gene expression levels among primates and may represent important molecular mechanisms in primate evolution. |
### Instruction:
Is notch3 necessary for blood vessel integrity in the central nervous system?
### Response:
| We demonstrate that Notch3 is important for survival of VSMC, and reveal a critical role for Notch3 and VSMC in blood vessel integrity and blood-brain barrier function in the mammalian vasculature. |
### Instruction:
Are immunosuppressive capabilities of mesenchymal stromal cells maintained under hypoxic growth conditions and after gamma irradiation?
### Response:
| We demonstrate that γ irradiation is an effective strategy to abrogate MSC proliferation without impairing the cells' immunosuppressive function. Hypoxia significantly enhanced MSC expansion, allowing for transplantation of MSCs with low passage number. In summary, our optimized MSC expansion protocol successfully addr... |
### Instruction:
Does maternal vitamin C deficiency during pregnancy result in transient fetal and placental growth retardation in guinea pigs?
### Response:
| Although no clinical differences between CTRL and DEF pups were observed at GD56, the present data suggest that vitC plays a role in early fetal development. Although no clinical differences between CTRL and DEF pups were observed at GD56, the present data suggest that vitC plays a role in early fetal development. Low ... |
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