question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does dNA methylation profiling reveal novel diagnostic biomarkers in renal cell carcinoma?
### Response:
| These DNA methylation profiles provide insights into the etiology of renal cell carcinoma and, most importantly, demonstrate clinically applicable biomarkers for use in early detection of kidney cancer. |
### Instruction:
Does [ Methyl-metabolism contribute to the LuxS regulation of Streptococcus mutans ]?
### Response:
| The methyl- metabolism pathway contributes to LuxS regulation on biofilm formation and auiduricity of Strecptococcus mutans. |
### Instruction:
Is femoral nerve block associated with persistent strength deficits at 6 months after anterior cruciate ligament reconstruction in pediatric and adolescent patients?
### Response:
| Pediatric and adolescent patients treated with FNB for postoperative analgesia after ACL reconstruction had significant isokinetic deficits in knee extension and flexion strength at 6 months when compared with patients who did not receive a nerve block. Patients without a block were 4 times more likely to meet criteria... |
### Instruction:
Does microRNA-150 protect the heart from injury by inhibiting monocyte accumulation in a mouse model of acute myocardial infarction?
### Response:
| Our findings indicate that miR-150 acts as a critical regulator of monocyte cell migration and production of proinflammatory cytokines, leading to cardioprotective effects against AMI-induced injury. Thus, miR-150 may be a suitable target for therapeutic intervention in the setting of ischemic heart disease. |
### Instruction:
Does helicobacter pylori Infection activate the Akt-Mdm2-p53 Signaling Pathway in Gastric Epithelial Cells?
### Response:
| These findings suggest that Akt-Mdm2-p53 signaling is involved in the molecular response of GES-1 cells to H. pylori infection. |
### Instruction:
Is chronic inflammation with Helicobacter pylori infection implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa?
### Response:
| We showed that miR-328 downregulation and de novo expression of CD44v9 occurred in H. pylori-infected gastric mucosa adjacent to gastric cancer compared with gastric mucosa not infected with H. pylori adjacent to gastric cancer. CD44v9-overexpressing cells are known to acquire reactive oxygen species resistance; thus, ... |
### Instruction:
Does chronic intermittent hypobaric hypoxia ameliorate endoplasmic reticulum stress mediated liver damage induced by fructose in rats?
### Response:
| Our results suggest that CIHH protect hepar against hepatic damage through inhibition of ERS in fructose-fed rats. CIHH might be the new therapy for NAFLD. |
### Instruction:
Does magainin-AM2 improve glucose homeostasis and beta cell function in high-fat fed mice?
### Response:
| These results indicate that magainin-AM2 improves glucose tolerance, insulin sensitivity and islet beta cells secretory responsiveness in mice with obesity-diabetes. |
### Instruction:
Does assessment of 3D motion increase the applicability of accelerometers for monitoring left ventricular function?
### Response:
| Accelerometer 3D systolic velocity showed very good correspondence to changes in global and regional left ventricular function. Our results demonstrate that by the use of the accelerometer 3D motion vector, no alignment of the sensor with the cardiac coordinate axes was required. This increases potential clinical appli... |
### Instruction:
Does histone deacetylase 6 inhibition impair effector CD8 T-cell functions during skin inflammation?
### Response:
| HDAC6, a key modifier of T-cell receptor signaling, might represent a novel target for the treatment of CD8 T cell-related skin diseases, including CHS and GVHD. |
### Instruction:
Does the essential Schizosaccharomyces pombe Pfh1 DNA helicase promote fork movement past G-quadruplex motifs to prevent DNA damage?
### Response:
| In the absence of functional Pfh1, unresolved G4 structures cause fork pausing and DNA damage of the sort associated with human tumors. |
### Instruction:
Does inactivation of Fam20C in cells expressing type I collagen cause periodontal disease in mice?
### Response:
| Loss of Fam20C function leads to periodontal disease in mice. The reduced levels of bone sialoprotein, osteopontin, dentin matrix protein 1, dentin sialoprotein, periostin and fibrillin-1 may contribute to the periodontal defects in the Fam20C-deficient mice. |
### Instruction:
Do impact of cogongrass management strategies on generalist predators in cogongrass-infested longleaf pine plantations?
### Response:
| Multiple applications of herbicide remain the most effective way to manage cogongrass in longleaf pine. In this study, we found limited evidence that cogongrass management with herbicides would negatively impact arthropod natural enemies associated with longleaf pine or locally increase root-feeding bark beetles. |
### Instruction:
Are intact parathyroid hormone levels associated with increased carotid intima media thickness in HIV infected patients?
### Response:
| Elevated iPTH was associated with subclinical atherosclerosis in HIV-infected subjects. Of note this association was statistically significant even for iPTH values within the range of normality. The existence of a causal relationship between iPTH and atherosclerosis needs to be fully explored in future investigations. |
### Instruction:
Does angiopoietin-like protein 4 significantly predict future cardiovascular events in coronary patients?
### Response:
| We conclude that plasma ANGPTL4 levels as well as ANGPTL4 variants significantly predict cardiovascular events independently of conventional cardiovascular risk factors. |
### Instruction:
Is social Communication Predicted by Inhibitory Ability and ADHD Traits in Preschool-Aged Children : A Mediation Model?
### Response:
| Our findings suggest that social communication difficulties in some young children are a downstream consequence of hyperactive-impulsive behaviors that arise from poorly developed inhibitory control. |
### Instruction:
Is the superparamagnetic iron oxide equivalent to the Tc99 radiotracer method for identifying the sentinel lymph node in breast cancer?
### Response:
| Detection of SLNs with SPIO allows for easy identification of axillary nodes, at a frequency not inferior to the radiotracer. It is an oncologically safe procedure, facilitates patients and operative room management and can be used to reliably identify SLNs in breast cancer. |
### Instruction:
Do poor toddler-age sleep schedules predict school-age behavioral disorders in a longitudinal survey?
### Response:
| Poor toddler-age sleep schedules were found to predict behavioral problems during primary-school age years. Thus, good and regular sleep habits appear to be important for young children's healthy development. |
### Instruction:
Does sPR4-peptide alter bone metabolism of normal and HYP mice?
### Response:
| SPR4-peptide has bimodal activity and acts by: (1) preventing DMP1 binding to PHEX and (2) sequestering an inhibitor of DMP1-PHEX binding, ASARM-peptide. In PHEX defective HYP-mice the second pathway predominates. Although SPR4-peptide improved trabecular calcification defects, decreased sclerostin and increased active... |
### Instruction:
Is central adiposity negatively associated with hippocampal-dependent relational memory among overweight and obese children?
### Response:
| Regional, but not whole-body, fat deposition was selectively and negatively associated with hippocampal-dependent relational memory among overweight/obese prepubertal children. |
### Instruction:
Does comprehensive analysis of patients with Stargardt macular dystrophy reveal new genotype-phenotype correlations and unexpected diagnostic revisions?
### Response:
| This study expands our knowledge of STGD by identifying dozens of novel alleles that cause the disease. The frequency of single mutations in ABCA4 among STGD patients is higher than that among controls, indicating that these mutations contribute to disease. Disease in 11 patients was explained by mutations outside ABCA... |
### Instruction:
Are parents interested in newborn genomic testing during the early postpartum period?
### Response:
| Interest in newborn genomic testing was high among parents of healthy newborns, and the majority of couples had similar levels of interest. Surveying parents about genomic sequencing did not prompt rejection of newborn screening.Genet Med 17 6, 501-504. |
### Instruction:
Is voluntary Activation Reduced in Both the More- and Less-Affected Upper Limbs after Unilateral Stroke?
### Response:
| Voluntary activation is impaired bilaterally in the upper-limb after stroke, with reduced cortical connectivity on the more-affected side. |
### Instruction:
Does dupilumab improve the molecular signature in skin of patients with moderate-to-severe atopic dermatitis?
### Response:
| This is the first report showing rapid improvement of the AD molecular signature with targeted anti-IL-4 receptor α therapy. These data suggest that IL-4 and IL-13 drive a complex, TH2-centered inflammatory axis in patients with AD. |
### Instruction:
Is less invasive surfactant administration associated with improved pulmonary outcomes in spontaneously breathing preterm infants?
### Response:
| Surfactant treatment of spontaneously breathing infants was associated with lower rates of mechanical ventilation and BPD. Additional large-scale randomised controlled trials are needed to assess the possible long-term benefits of LISA. |
### Instruction:
Does pretreatment of pericardial patches with antibiotics alter patch healing in vivo?
### Response:
| Pretreatment of bovine pericardial patches with the antibiotics bacitracin or cephalexin has no detrimental effect on early patch healing, with similar neointimal thickness, cellular infiltration, and numbers of M2 macrophages compared with control patches. These results suggest that the host vessel response to patch a... |
### Instruction:
Does the diastolic pulmonary gradient predict survival in patients with pulmonary hypertension due to left heart disease?
### Response:
| In this retrospective study of patients with cardiomyopathy and PH-LHD, an elevated DPG was not associated with worse survival. |
### Instruction:
Does nrf2 regulate ROS production by mitochondria and NADPH oxidase?
### Response:
| These observations suggest that the Keap1-Nrf2 pathway regulates both mitochondrial and cytosolic ROS production through NADPH oxidase. |
### Instruction:
Do dLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer?
### Response:
| Oral clefts were associated with positive self-reported family history of cancer and with variants in DLX1 and MMP3. The association between oral clefts and cancer raises interesting possibilities to identify risk markers for cancer. |
### Instruction:
Are infants born late/moderately preterm at increased risk for a positive autism screen at 2 years of age?
### Response:
| LMPT infants are at significantly increased risk for positive autistic screen. An M-CHAT follow-up interview is essential as screening for autism spectrum disorders is especially confounded in preterm populations. Infants with false positive screens are at risk for cognitive and behavioral problems. |
### Instruction:
Does a NOS3 polymorphism determine endothelial response to folate in children with type 1 diabetes or obesity?
### Response:
| A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies. |
### Instruction:
Is fCGR2A rs1801274 polymorphism associated with risk of childhood-onset idiopathic ( immune ) thrombocytopenic purpura : evidence from a meta-analysis?
### Response:
| Our present meta-analysis indicated that FCGR H131R polymorphism might not be associated with risk of ITP in overall population. However, in Caucasian childhood-onset subgroup, there might be an association between FCGR2A H131R polymorphism and ITP risk, which is not robust and should be explained with caution. |
### Instruction:
Is recurrent CYP2C19 deletion allele associated with triple-negative breast cancer?
### Response:
| Our results indicate that inherited changes in CYP2C19 gene participating in estrogen catabolism have an influence on the molecular subtype of breast cancer. |
### Instruction:
Are increased serum mannose binding lectin levels associated with diabetic retinopathy?
### Response:
| In type 2 diabetic patients, evaluated serum levels of MBL can be seen as an independent marker of DR even after correcting for possible confounding factors. |
### Instruction:
Does number of tumor foci predict prognosis in papillary thyroid cancer?
### Response:
| An increase in the number of tumors is associated with a tendency toward more aggressive features and predicts poor prognosis in PTC. |
### Instruction:
Does valproate treatment normalize EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients?
### Response:
| VPA treatment normalizes EEGfC in IGE patients. |
### Instruction:
Is autosomal recessive non-syndromic hearing loss caused by novel compound heterozygous mutations in TMC1 from a Tibetan Chinese family?
### Response:
| The novel compound heterozygous mutant alleles of TMC1 identified in this study were responsible for the ARNSHL in this Tibetan Chinese family. Although compound heterozygous mutations in TMC1 occurring in different TMC1 domains have been previously described in Han Chinese; this result suggests that the TMC1 variants ... |
### Instruction:
Does the combined use of conventional MRI and MR spectroscopic imaging increase the diagnostic accuracy in amyotrophic lateral sclerosis?
### Response:
| Precentral gyrus T2-hypointensity and NAA peak are not significantly correlated in ALS patients, suggesting that they reflect relatively independent phenomena. The combined use of these measures improves the diagnostic accuracy of MRI in ALS diagnosis. |
### Instruction:
Is activation of epidermal growth factor receptor required for Chlamydia trachomatis development?
### Response:
| Cumulatively, the data reported here connect the function of EGFR to C. trachomatis attachment and development in the host cells, and this could lead to new venues for targeting C. trachomatis infections and associated diseases. |
### Instruction:
Does maternal diet but not gestational weight gain predict central adiposity accretion in utero among pregnant adolescents?
### Response:
| Extreme sugar intakes among pregnant adolescents may lead to increased accumulation of fetal abdominal fat with little net effect on birth weight. This finding suggests that increased sugar consumption during pregnancy promotes shifts in fetal body composition. |
### Instruction:
Does soluble ST2 reflect hemodynamic stress in non-ischemic heart failure?
### Response:
| Our results imply that in non-ischemic heart failure, sST2 reflects hemodynamic stress rather than pathogenic processes in the myocardium. |
### Instruction:
Is neutrophil-Lymphocyte ratio associated with arterial stiffness in diabetic retinopathy in type 2 diabetes?
### Response:
| The findings showed that NLR and baPWV are elevated both in T2DM and in DR. In addition, NLR is independently associated with baPWV. Early detection of abnormal NLR levels may be helpful for the search of subclinical atherosclerosis in patients with T2DM and DR. |
### Instruction:
Is magnetic suppression of perceptual accuracy reduced in episodic migraine without aura?
### Response:
| The results demonstrate that occipital cortex inhibition as assessed with MSPA is not reduced in episodic migraine without aura. This suggests a larger role of occipital cortex excitability in episodic migraine with aura and in chronic migraine compared to episodic migraine without aura. Test-retest reliability of MSPA... |
### Instruction:
Is plasma level of the endogenous sodium pump ligand marinobufagenin related to the salt-sensitivity in men?
### Response:
| In men, MBG increases with 24-h ABP, and similar to Dahl salt-sensitive rats, 4 weeks of high-salt induced MBG response is accompanied by marked salt sensitivity. However, these patterns seem to be sex-specific and are not observed in women. |
### Instruction:
Does adenosine monophosphate-activated protein kinase activation protect against sepsis-induced organ injury and inflammation?
### Response:
| In this model, activation of AMPK was protective, and AICAR minimized organ injury by decreasing inflammatory cytokines and endothelial activation. These data suggest that AMPK signaling influences sepsis or LPS-induced endothelial activation and organ injury. |
### Instruction:
Do breast cancers with a BRCA1-like DNA copy number profile recur less often than expected after high-dose alkylating chemotherapy?
### Response:
| BRCA1-like tumors recurred significantly less often after HD than conventional chemotherapy. BRCA1-like copy-number profile classification may be a predictive marker for HD alkylating chemotherapy. |
### Instruction:
Does cochlear implantation improve localization ability in patients with unilateral deafness?
### Response:
| Cochlear implantation is effective in improving localization abilities in subjects with unilateral deafness. The root mean square error dropped significantly with binaural hearing compared to monaural hearing. |
### Instruction:
Does microRNA-223 inhibit tissue factor expression in vascular endothelial cells?
### Response:
| MiR-223-mediated suppression of TF expression provides a novel molecular mechanism for the regulation of coagulation cascade, and suggests a clue against thrombogenesis during the process of atherosclerotic plaque rupture. |
### Instruction:
Is non-HDL cholesterol a better target for predicting periprocedural myocardial injury following percutaneous coronary intervention in type 2 diabetes?
### Response:
| In poorly-controlled diabetic patients (HbA1c ≥ 7%) undergoing PCI, non-HDL-C but not LDL-C was independently associated with and increased risk of PMI, and non-HDL-C levels ≥ 130 mg/dl had a worse PMI risk profile compared with non-HDL-C levels <100 mg/dl. |
### Instruction:
Do serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer?
### Response:
| High serum miR-155 and miR-221 during the first 2 weeks of CRT were associated with the development of severe RIET, suggesting that these miRNAs may be useful as an early surrogate for this form of toxicity. |
### Instruction:
Is elevated CETP activity during acute phase of myocardial infarction independently associated with endothelial dysfunction and adverse clinical outcome?
### Response:
| An enhanced CETP activity during acute phase of STEMI is independently associated with endothelial dysfunction and adverse clinical outcome. |
### Instruction:
Are lower levels of plasma adiponectin and endothelial progenitor cells associated with large artery atherosclerotic stroke?
### Response:
| Adiponectin is positively correlated with EPCs levels, and both of them are independently associated with LAA stroke. |
### Instruction:
Is constipation reduced by beta-blockers and increased by dopaminergic medications in Parkinson 's disease?
### Response:
| Beta-blockers are associated with a lower risk of constipation, while dopaminergic treatments appear to increase risk of constipation. |
### Instruction:
Are multiflagellated sperm cells of Ceratopteris richardii bathed in arabinogalactan proteins throughout development?
### Response:
| We demonstrated that AGPs are abundant in the EPM and along the plasmalemma and that the three AGP epitopes have specific expression patterns during development. Coupled with inhibition studies, these results identify AGPs as critical to the formation of an extraprotoplasmic matrix and the consequent origin and develop... |
### Instruction:
Does yucca aloifolia ( Asparagaceae ) opt out of an obligate pollination mutualism?
### Response:
| These results indicate that even highly specialized mutualisms may not be entirely obligate interactions or evolutionary dead ends. |
### Instruction:
Does brain response to thermal stimulation predict outcome of patients with chronic disorders of consciousness?
### Response:
| Using fMRI and EEG to measure brain responses to thermal stimulation is capable of predicting patient outcomes with a high degree of predictive accuracy. |
### Instruction:
Does experimental pain have a greater effect on single motor unit discharge during force-control than position-control tasks?
### Response:
| The effect of pain on muscle activity appears unique to the contraction type, with less influence during position- than force-control tasks. |
### Instruction:
Does exome Sequencing identify DYNC1H1 Variant Associated With Vertebral Abnormality and Spinal Muscular Atrophy With Lower Extremity Predominance?
### Response:
| De novo mutations of DYNC1H1 have been found in individuals with autosomal dominant mental retardation with neuronal migration defects. Dominantly inherited mutations of DYNC1H1 have been reported to cause spinal muscular atrophy with predominance of lower extremity involvement and Charcot-Marie-Tooth type 2O. This is ... |
### Instruction:
Does routine bacterial screening of platelet concentrate by flow cytometry and its impact on product safety and supply?
### Response:
| Testing of PCs by BactiFlow was successfully implemented in our blood donation service and proved sufficient as a rapid and reliable screening method. False reactive results are in an acceptable range since the transfusion of 12 bacterially contaminated PCs was prevented. |
### Instruction:
Are early venous thromboembolic events associated with worse prognosis in patients with lung cancer?
### Response:
| EVTE are associated with worse OS, irrespective of stage of the disease. Our findings underscore the need for an efficient preventive strategy for VTE among patients with lung cancer. |
### Instruction:
Does remifentanil-based anaesthesia increase the incidence of postoperative surgical site infection?
### Response:
| Remifentanil-based anaesthesia increased the incidence of SSI. A possible reason may be opioid-induced immunosuppression or opioid withdrawal-induced immunosuppression. |
### Instruction:
Does tomato juice consumption improve blood antioxidative biomarkers in overweight and obese females?
### Response:
| Our results suggest that tomato juice reduces oxidative stress in overweight (and possibly obese) females and, therefore, may prevent from obesity related diseases and promote health. |
### Instruction:
Is the therapeutic effect of collateral meridian therapy comparable to acupoint pressure therapy in treating myofascial pain syndrome?
### Response:
| Both APT and CMT have comparable therapeutic efficacy in the treatment of unilateral upper back pain with active myofascial trigger points in the upper trapezius muscle. |
### Instruction:
Is whatsApp Messenger useful and reproducible in the assessment of tibial plateau fractures : inter- and intra-observer agreement study?
### Response:
| We found an excellent inter- and intra-observer agreement in the imaging assessment of tibial plateau fractures sent via WhatsApp Messenger. The authors now propose the systematic use of the application to facilitate faster documentation and obtaining the opinion of an experienced consultant when not on call. Finally, ... |
### Instruction:
Is extensive thoracic aortic calcification an independent predictor of development of coronary artery calcium among individuals with coronary artery calcium score of zero?
### Response:
| The likelihood of conversion to CAC>0 increases with increasing TAC scores. TAC ≥ 100 is an independent predictor of CAC conversion. Subjects with CAC = 0 and extensive TAC (TAC ≥ 100) may merit earlier repeat scanning than those with no TAC or lower TAC scores. |
### Instruction:
Does plasma stromal cell-derived factor 1α/CXCL12 level predict long-term adverse cardiovascular outcomes in patients with coronary artery disease?
### Response:
| Plasma CXCL12 level is a strong independent predictor of adverse cardiovascular outcomes in patients with CAD and improves risk reclassification. |
### Instruction:
Does thalamo-frontal connectivity mediate top-down cognitive functions in disorders of consciousness?
### Response:
| In our sample of patients, the dissociation between overt behavior observable in clinical assessments and residual cognitive faculties is prevalent among DOC patients (37%). A substantial number of patients, including some diagnosed with VS, can demonstrate willful engagement in top-down cognition. While neuroimaging d... |
### Instruction:
Does direct bone morphogenetic protein 2 and Indian hedgehog gene transfer for articular cartilage repair using bone marrow coagulate?
### Response:
| IHH gene transfer is effective to improve repair cartilage quality in vivo, whereas BMP2 treatment, carried the risk intralesional bone formation. Therefore IHH protein can be considered as an attractive alternative candidate growth factor for further preclinical research and development towards improved treatments for... |
### Instruction:
Does saccharomyces cerevisiae biofilm tolerance towards systemic antifungals depend on growth phase?
### Response:
| We showed that in vitro susceptibility to antifungal drugs was independent of biofilm or planktonic growth mode. Instead, drug tolerance was a consequence of growth arrest achievable by both planktonic and biofilm populations. Our results suggest that efficient strategies for treatment of yeast biofilm might be develop... |
### Instruction:
Does myocardial preconditioning reduce kidney injury and apoptosis induced by myocardial ischaemia and reperfusion?
### Response:
| MPC significantly reduces kidney injury and apoptosis induced by myocardial I/R. The underlying mechanisms might be related to inhibition of both the extrinsic and intrinsic pathways of apoptosis, possibly via inhibition of TNF-α production, modulation of Bcl-2 and Bax and activation of Akt and ERK1/2. |
### Instruction:
Does hypothermia reduce but Hyperthermia Augments T Cell-Derived Release of Interleukin-17 and Granzyme B that Mediate Neuronal Cell Death?
### Response:
| Hypothermia reduced but hyperthermia augmented T cell-derived release of IL-17 and GrB that mediate neuronal cell death, suggesting that the attenuation of T cell-derived release of these factors by therapeutic hypothermia leads to the inhibition of neuronal cell death in the delayed phase of brain injury. Moreover, hy... |
### Instruction:
Does cadmium exposure and atherosclerotic carotid plaques -- result from the Malmö diet and Cancer study?
### Response:
| These results extend previous studies on cadmium exposure and clinical cardiovascular events by adding data on the association between cadmium and underlying atherosclerosis in humans. The role of smoking remains unclear. It may both cause residual confounding and be a source of pro-atherogenic cadmium exposure. |
### Instruction:
Do zoroastrians support oocyte and embryo donation program for infertile couples?
### Response:
| Our preliminary data showed that Zoroastrians supported both OD and ED program equally for infertile couples. |
### Instruction:
Do biallelic mutations in BRCA1 cause a new Fanconi anemia subtype?
### Response:
| We establish that biallelic BRCA1 mutations cause a distinct FA-S, which has implications for risk counselling in families where both parents harbor BRCA1 mutations. The genetic basis of hereditary cancer susceptibility syndromes provides diagnostic information, insights into treatment strategies, and more accurate rec... |
### Instruction:
Is nocardia-induced granulocyte macrophage colony-stimulating factor neutralized by autoantibodies in disseminated/extrapulmonary nocardiosis?
### Response:
| In previously healthy adults with otherwise unexplained disseminated/extrapulmonary Nocardia infections, anti-GM-CSF autoantibodies should be considered. Their presence may suggest that these patients may be at risk for later development of pulmonary alveolar proteinosis or other opportunistic infections, and that pati... |
### Instruction:
Does biliary sphincteroplasty facilitate retrieval of proximally migrated plastic biliary stent?
### Response:
| Balloon biliary sphincteroplasty increases the success rate of retrieving proximally migrated biliary stents. The procedure is safe, technically easy and yields a good success rate in our experience. |
### Instruction:
Are muscle quality and relative adiposity the strongest predictors of lower-extremity physical function in older women?
### Response:
| Muscle quality and relative adiposity are the strongest independent predictors of LEPF in older women. These findings suggest that maintaining muscle quality, especially relative to adiposity, may be a critical target for interventions to prevent declines in physical function in older women. |
### Instruction:
Does successful treatment of sudden sensorineural hearing loss assure improvement of accompanying tinnitus?
### Response:
| Optimal and successful treatment of SSNHL may be an important factor in obtaining favorable long-term control of tinnitus accompanied by SSNHL. |
### Instruction:
Does azathioprine reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis?
### Response:
| We conclude that in the absence of inflammation, azathioprine does not affect intestinal tumorigenesis. |
### Instruction:
Does glytan decrease portal pressure via mesentery vasoconstriction in portal hypertensive rats?
### Response:
| The decreased PP and PTBF observed after Glytan treatment were related to increased mesenteric vasoconstriction and increased receptor sensitivity to vasoconstrictor. |
### Instruction:
Do estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53?
### Response:
| Direct ER treatment may prove to be an attractive alternative therapy in the treatment of human colorectal tumors in the future. |
### Instruction:
Is the preoperative serum C-reactive protein level a useful predictor of surgical site infections in patients undergoing appendectomy?
### Response:
| Preoperative elevation of the serum CRP level (> 65 mg/l) is a valuable predictor of SSI in patients undergoing appendectomy. |
### Instruction:
Does contingency management improve smoking cessation treatment outcomes among highly impulsive adolescent smokers relative to cognitive behavioral therapy?
### Response:
| CM-based interventions may improve the low smoking cessation rates previously observed among impulsive adolescent smokers. |
### Instruction:
Are both volumetry and functional connectivity of Heschl 's gyrus associated with auditory P300 in first episode schizophrenia?
### Response:
| The findings point towards both decreased volume of Heschl's gyrus and its altered functional pathways may contribute to auditory P300 abnormality in schizophrenia. |
### Instruction:
Is expression of marA remarkably increased from the early stage of development of fluoroquinolone-resistance in uropathogenic Escherichia coli?
### Response:
| These results suggested that marA expression is a sensitive marker for early detection of development of LVFX-resistance. |
### Instruction:
Does lysophosphatidic acid mediate fibrosis in injured joints by regulating collagen type I biosynthesis?
### Response:
| Taken together, these results identify an attractive target for intervention in reducing the progression of post-traumatic fibrosis and osteoarthritis. |
### Instruction:
Does thrombin generation and coagulation factor content of thawed plasma and platelet concentrate?
### Response:
| These data suggest thrombin generation is relatively unaltered when RTFP24 is thawed and stored for 6 days, and that the supernatant of PC has significant haemostatic capacity. |
### Instruction:
Is dianthin-EGF an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma?
### Response:
| This therapy has great advantage because of high specificity, low side effects and great effectiveness for future development in the treatment of colon cancer. |
### Instruction:
Is early treatment with rutoside and ascorbic acid highly effective for progressive pigmented purpuric dermatosis?
### Response:
| Oral rutoside and ascorbic acid may be an efficient and well tolerated treatment for PPPD. Early treatment is recommended to achieve best clinical outcome. |
### Instruction:
Does the expression of miR-125b regulate angiogenesis during the recovery of heat-denatured HUVECs?
### Response:
| Taken together our results show that the expression of miR-125b is time-dependent and miR-125b plays a regulatory role of angiogenesis during wound healing after burns. |
### Instruction:
Does stone size limit the use of Hounsfield units for prediction of calcium oxalate stone composition?
### Response:
| For calcium stones, the ability of CT HUs to predict stone composition was limited, likely due to the mixed stone composition. Within a cohort of CaOxMH stone formers, measured HUs varied linearly with stone size. All stones <5 mm were below thresholds for CaOxMH composition. |
### Instruction:
Does mutation of EpCAM lead to intestinal barrier and ion transport dysfunction?
### Response:
| Knock-down EpCAM cell model of congenital tufting enteropathy was developed. In vivo inducible mouse model was developed resulting in mutant EpCAM protein. Cells with EpCAM deficiency demonstrated barrier and ion transport dysfunction. Tamoxifen-treated Epcam (Δ4/Δ4) mice demonstrated pathological features. Epcam (Δ4/Δ... |
### Instruction:
Is heart rate recovery impaired after maximal exercise testing in children with sickle cell anemia?
### Response:
| Children with SCA demonstrate impaired HRR after maximal exercise. Reduced postexercise HRR in SCA suggests impaired parasympathetic function, which may become progressively worse with age, in this population. |
### Instruction:
Does the saponin DT-13 inhibit gastric cancer cell migration through down-regulation of CCR5-CCL5 axis?
### Response:
| DT-13 inhibited gastric cancer cell migration by down-regulation of the CCR5-CCL5 axis. |
### Instruction:
Does low dispositional mindfulness predict self-medication of negative emotion with prescription opioids?
### Response:
| Self-medication of negative emotions with opioids was prevalent in this sample and related to low dispositional mindfulness. Plausibly, increasing mindfulness may decrease opioid self-medication. Addictive automaticity and emotion regulation are discussed as potential mechanisms linking low dispositional mindfulness an... |
### Instruction:
Is overexpression of E2F1 in human gastric carcinoma involved in anti-cancer drug resistance?
### Response:
| Overexpression of E2F1 promotes the development of MDR in gastric carcinoma, suggesting that E2F1 may represent an efficacious target for gastric cancer therapy. |
### Instruction:
Is amniotic fluid `` sludge '' an independent risk factor for preterm delivery?
### Response:
| AFS is an independent risk factor for PTB before 35 weeks. |
### Instruction:
Is vestibular dysfunction a clinical feature of the Jervell and Lange-Nielsen Syndrome?
### Response:
| We identified a high frequency of symptoms and signs associated with vestibular dysfunction in deaf JLNS cases, irrespective of previous cochlear implantation. Disruption of endolymph homeostasis in the inner ear, including cochlea and vestibular system, by profound KCNQ1 function loss is the proposed mechanism. |
### Instruction:
Do mineralocorticoid receptor antagonists modulate galectin-3 and interleukin-33/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction?
### Response:
| MRAs play a pivotal role in the Gal-3 and IL-33/ST2 modulation in post-MI cardiac remodeling. |
### Instruction:
Are parameters for lithium treatment critical in its enhancement of fracture-healing in rodents?
### Response:
| A later onset of lithium administration significantly improved femoral fracture-healing. Trends indicated that a lower dose and longer treatment duration also had a positive effect on fracture repair. |
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