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### Instruction:
Do endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 explain abnormal cortisol metabolism in polycystic ovary syndrome?
### Response:
| The altered cortisol metabolism in polycystic ovarian syndrome, which is consistent with impaired 11beta-HSD1 activity, cannot be accounted for by increased production of measurable endogenous inhibitors of this enzyme. |
### Instruction:
Does predictive value of novel stimuli modify visual event-related potentials and behavior?
### Response:
| The enhanced N2 for 100% predictive novel stimuli appears to index an alerting system facilitating behavioral detection. The same novel stimuli with no predictive value distract attention and generate a different ERP pattern characterized by increased novelty P3a and target P3b responses. The results indicate that beha... |
### Instruction:
Is `` BPSA , '' a specific molecular form of free prostate-specific antigen , found predominantly in the transition zone of patients with nodular benign prostatic hyperplasia?
### Response:
| We have identified a specific molecular form of clipped free PSA, called BPSA, that is increased within the prostatic TZ of patients exhibiting nodular BPH. Higher levels of percent free PSA in serum have been found to correlate strongly with prostate volume, which in turn is closely associated with the progressive enl... |
### Instruction:
Do sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines?
### Response:
| We conclude that Cys, Met, N-acetylcysteine, and DL-homocysteine differentially inhibit DDP toxicity and uptake in cultured S1, S3, and DCT cells, and that the inhibition of uptake, as well as the complexation of DDP with Cys within the cell, may prevent toxicity. The structural element R-CH(NH2)-[CH2]1 2-S-R, which is... |
### Instruction:
Does lV-powered coronary sinus retroperfusion reduce infarct size in acutely ischemic pigs?
### Response:
| The LVCSS reduces infarct size in pigs after acute coronary artery occlusion. The addition of PCSO to LVCSS further improves myocardial salvage. |
### Instruction:
Is weekly lometrexol with daily oral folic acid appropriate for phase II evaluation?
### Response:
| Weekly administration of lometrexol is feasible and well-tolerated when coadministered with daily oral folic acid. The nature of the interaction between natural folates and lometrexol that renders this schedule feasible remains unclear. A definition of dose-limiting toxicity that incorporated attention to dose omission... |
### Instruction:
Is mnSOD expression increased in metastatic gastric cancer?
### Response:
| MnSOD expression is upregulated in the primary tumors of gastric cancer patients with lymph node metastases. This finding supports an involvement of MnSOD and possibly the reactive oxygen status of the gastric tumor microenvironment in gastric cancer metastasis. |
### Instruction:
Does protease inhibitor reduce loss of tensile strength in rat anastomosis with peritonitis?
### Response:
| These findings suggest that NM may be clinically useful for preventing intestinal leakage, particularly when anastomoses are performed under protease-activating conditions, such as intestinal edema and inflammation. |
### Instruction:
Does epidermal growth factor-induced cytoprotection in human intestinal cells involve intracellular calcium signaling?
### Response:
| Taken together, these data strongly suggest that the cytoprotective effects of EGF may involve Ca(2+) signaling. |
### Instruction:
Do esmolol-induced regional wall motion abnormalities affect regional ventricular elastances?
### Response:
| Regional and global elastances and maximal stroke volumes may not identify esmolol-induced left ventricular regional dysfunction in dogs. The primary effect of asynchrony of regional contraction is global cardiac dilation. Systemic dobutamine infusion increases regional and global left ventricular elastances but does n... |
### Instruction:
Is indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles related to toxicity?
### Response:
| A non specific permeabilization of the BBB, probably related to the toxicity of the carrier, may account for the CNS penetration of dalargin associated with PBCA NP and polysorbate 80. |
### Instruction:
Does ethanol increase the neurotoxic effect of tumor necrosis factor-alpha in cultured rat astrocytes?
### Response:
| These studies suggest that ethanol increases the susceptibility of astrocytes to TNFalpha-induced cell death by shifting the balance of sphingolipid metabolism in favor of a pathway that increases the susceptibility of astrocytes to the cytotoxic effect of TNFalpha. |
### Instruction:
Is spinal position sense independent of the magnitude of movement?
### Response:
| 1) Healthy individuals are able to reposition their spine accurately under conditions of incremental increases in angular range. 2) Range-related variations in position sense are small and unlikely to be of clinical significance. |
### Instruction:
Is apoptosis a prominent feature of acute anterior uveitis in the Fischer 344 rat?
### Response:
| Apoptosis occurs early in the course of rat EMIU and EIU, and may contribute to resolution of these diseases. In general, infiltrating mononuclear cells die rapidly, while neutrophils survive, producing inducible nitric oxide synthase which may contribute to disease pathogenesis. |
### Instruction:
Does a complex urologic problem demonstrate how far pediatric urology has progressed?
### Response:
| The CCMC experience with SSBUE demonstrates the recent achievements in complex urinary tract reconstruction that have taken place in pediatric urology. We describe diagnostic studies such as formal urodynamics and the growing trend to identify urologic problems antenatally. A team approach involving the obstetrician, p... |
### Instruction:
Do vein interposition cuffs decrease the intimal hyperplastic response of polytetrafluoroethylene bypass grafts?
### Response:
| PTFE bypass grafts with VCs had less IH develop than did grafts with ES and PC anastomoses. IH regression in VCs at 4 weeks suggests compensatory vessel wall remodeling mediated by the presence of the VC. Furthermore, VCs caused a redistribution of hyperplasia to the vein-PTFE interface, delaying IH-induced outflow obs... |
### Instruction:
Does financial status predict weight loss after bariatric surgery?
### Response:
| After standard preoperative evaluation and screening, patients loss weight following VBG independent of insurance status. Source of funding should, therefore, not preclude patients from undergoing bariatric surgery. Patients with limited financial resources can expect similar outcomes as patients with commercial insura... |
### Instruction:
Does prenatal orogastric gene delivery result in transduction of the small bowel in the fetal rabbit?
### Response:
| There was significant maternal and fetal loss related to anesthetic and husbandry issues when surgery was performed at 22 or 28 days of gestation. Based on these preliminary results, we conclude that orogastric gene delivery in the rabbit fetus at 25 days' gestation is an encouraging animal model to study fetal deliver... |
### Instruction:
Does intestinal ischemia and reperfusion impair vasomotor functions of pulmonary vascular bed?
### Response:
| Basal and agonist-stimulated release of nitric oxide from the pulmonary vascular endothelium and the ability of pulmonary smooth muscle to contract in response to angiotensin II were impaired by intestinal I/R. Such functional impairment in both pulmonary vascular endothelium and smooth muscle may contribute to the alv... |
### Instruction:
Do single SPECT measures of cerebral cortical perfusion reflect time-index estimation of dementia severity in Alzheimer 's disease?
### Response:
| Cerebral cortical perfusion loss is temporally related to development of dementia. The spatial pattern of high, significant correlations between cortical perfusion and dementia severity shows a regional distribution that corresponds closely to the distribution of AD pathology described in autopsy studies. |
### Instruction:
Do plasma D-dimer levels in operable breast cancer patients correlate with clinical stage and axillary lymph node status?
### Response:
| Plasma D-dimer levels were markers of lymphovascular invasion, clinical stage, and lymph node involvement in operable breast cancer. This correlation suggests that detectable fibrin degradation, as measured by plasma D-dimer, is a clinically important marker for lymphovascular invasion and early tumor metastasis in ope... |
### Instruction:
Is survival in early breast cancer patients favorably influenced by a natural humoral immune response to polymorphic epithelial mucin?
### Response:
| Early breast cancer patients with a natural humoral response to MUC1 have a higher probability of freedom from distant failure and a better disease-specific survival. MUC1 antibodies may control hematogenic tumor dissemination and outgrowth by aiding the destruction of circulating or seeded MUC1-expressing tumor cells.... |
### Instruction:
Does interaction of human IgE with Fc epsilon RI alpha expose hidden epitopes on IgE?
### Response:
| The presented data support the hypothesis of a conformational change within IgE Cepsilon3 upon receptor binding by showing that monoclonal antibodies raised against recombinant Cepsilon3 differently recognize soluble and receptor-bound IgE. The presence of an IgE portion in sera of human donors that is recognized by 8E... |
### Instruction:
Does the recognition pattern of sequential B cell epitopes of beta-lactoglobulin vary with the clinical manifestations of cow 's milk allergy?
### Response:
| Using IgE Pin-ELISAs we were able to confirm previously described sequential B cell epitopes of BLG. However, the recognition pattern of one of the major cow's milk allergens is not predictive of the clinical type of reaction. |
### Instruction:
Is heparin , derived from the mast cells of human lungs responsible for the generation of kinins in allergic reactions due to the activation of the contact system?
### Response:
| These in vitro results explain the results of in vivo allergen challenge studies where a high degree of kinin generation occurs. Heparin derived from human mast cells therefore seems to represent the physiological macromolecule capable of activating the contact system and could be a missing link between cellular and hu... |
### Instruction:
Does four-hourly scheduling of temozolomide improve tumour growth delay but not therapeutic index in A375M melanoma xenografts?
### Response:
| The 4-hourly schedule of temozolomide delayed tumour growth significantly more than the once-daily and 12-hourly schedules, probably as a result of greater DNA damage inflicted, but also increased toxicity. It remains to be seen if this regimen confers a net benefit over the standard schedule. |
### Instruction:
Does endothelium-derived nitric oxide contribute to the regulation of venous tone in humans?
### Response:
| Human forearm capacitance veins exhibit both stimulated and basal NO activity, which indicates that NO contributes not only to the regulation of venous tone but also to resting venous tone in healthy human subjects. |
### Instruction:
Does insertion/deletion polymorphism in the angiotensin-converting enzyme gene affect heart weight?
### Response:
| ACE genotype predicts cardiac mass; however, it was less effective than epigenetic factors such as hypertension or age. |
### Instruction:
Does an aldose redutase inhibitor prevent the intimal thickening in coronary arteries of galactose-fed beagle dogs?
### Response:
| This report morphologically shows diabetes-like macrovascular abnormalities in galactosaemic animals, suggesting that polyol pathway hyperactivity is closely related to the development of diabetic macroangiopathy, which could be prevented by aldose reductase inhibition. |
### Instruction:
Is an untranslated insertion variant in the uncoupling protein 2 gene related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men?
### Response:
| In a large group of Danish Caucasian men we found no association between a 3'untranslated insertion polymorphism in the UCP2 gene and obesity. Neither did we identify a relation between this variant and BMI changes during adult age. |
### Instruction:
Do systemic perfluorocarbons suppress the acute lung inflammation after gastric acid aspiration in rats?
### Response:
| Intraperitoneally administered perfluorocarbons in rats attenuate the neutrophilic infiltration in the lung after acid aspiration, thereby decreasing the alveolar protein leakage and improving pulmonary compliance. |
### Instruction:
Does s-Nitroso-N-acetylpenicillamine ( SNAP ) during hemorrhagic shock improve mortality as a result of recovery from vascular hyporeactivity?
### Response:
| The administration of a small dose of S-nitroso-N-acetylpenicillamine (a nitric oxide donor), a dose which did not exert a significant vasodilator effect, was administered during hemorrhagic shock in dogs. S-nitroso-N-acetylpenicillamine improved the vascular hyporeactivity to noradrenaline and decreased the mortality ... |
### Instruction:
Does compound heterozygous hemochromatosis genotype predict increased iron and erythrocyte indices in women?
### Response:
| Women with the compound heterozygous HFE genotype C282Y/H63D, but not the C282Y wild-type genotype, had increased values for serum iron and transferrin saturation, and the younger age group also had increased hemoglobin values. We conclude that the compound heterozygous genotype may have a beneficial effect in protecti... |
### Instruction:
Does ischemic preconditioning enhance recovery of isolated rat lungs after hypothermic preservation?
### Response:
| Preconditioning attenuates deterioration in lung compliance on reperfusion to a degree dependent on the protocol used. |
### Instruction:
Are antineural and antinuclear autoantibodies of prognostic relevance in non-small cell lung cancer?
### Response:
| Antineural and antinuclear autoantibodies are a stage-independent prognostic factor in patients with NSCLC and may represent an effective immune response to the tumor. |
### Instruction:
Does oxidative DNA damage in circulating leukocytes occur as an early event in chronic HCV infection?
### Response:
| The 8-OHdG level in circulating leukocytes is a reliable marker of oxidative stress occurring in the liver of individuals with chronic HCV infection. DNA oxidative damage appears to be an early and unique event in the natural history of HCV-related hepatitis. This injury increases the risk of genomic damage and may be ... |
### Instruction:
Does prevalence and correlate of parkinsonism in an institutionalized population of geriatric patients with chronic schizophrenia?
### Response:
| The present correlations suggest potential overlap among the neural substrates for bradykinesia, cognitive impairment and negative symptoms; however, further research is required to clarify that issue. |
### Instruction:
Does aortic atherosclerosis at middle age predict cerebral white matter lesions in the elderly?
### Response:
| The pathogenetic process that leads to cerebral periventricular white matter lesions starts already in or before midlife. The critical period for intervention directed at prevention of white matter lesions and its cognitive consequences may be long before these lesions become clinically detectable. |
### Instruction:
Is tumor radiosensitivity ( SF2 ) a prognostic factor for local control in head and neck cancers?
### Response:
| This study has shown that tumor radiosensitivity measured as SF2 is a significant prognostic factor for local control in head and neck cancers. |
### Instruction:
Do tropomodulin and tropomyosin mediate lens cell actin cytoskeleton reorganization in vitro?
### Response:
| Expression and sequential assembly of low-molecular-weight tropomyosin and Tmod into the cortical actin cytoskeleton of differentiated lens cells may help to reorganize the actin cytoskeleton during morphogenetic differentiation. Moreover, lens epithelial cell differentiation may include the generation of novel Tmod-co... |
### Instruction:
Does regional low-flow perfusion provide cerebral circulatory support during neonatal aortic arch reconstruction?
### Response:
| Regional low-flow perfusion is a safe and simple bypass management technique that provides cerebral circulatory support during neonatal aortic arch reconstruction. The reduction of deep hypothermia and circulatory arrest time required may reduce the risk of cognitive and psychomotor deficits. |
### Instruction:
Does radiation-induced gadd45 expression correlate with clinical response to radiotherapy of cervical carcinoma?
### Response:
| Our results support the measure of the induction of gadd45, and possibly of other genes required for regulated G1-S checkpoint, as a method useful for prognostic evaluation of cervical carcinoma patients. |
### Instruction:
Does variables affecting salivary Streptococcus mutans count in a cohort of 12-year-old subjects?
### Response:
| On the basis of these results, it is suggested that acidogenicity is not only a cariogenic factor, but also a factor promoting colonization of oral sites by Sm, especially in subjects with a high frequency of sugar consumption. |
### Instruction:
Is fucosylation of IgG heavy chains increased in rheumatoid arthritis?
### Response:
| Fucose on IgG heavy chains is significantly increased in patients with rheumatoid arthritis. |
### Instruction:
Is pSP94 ( or beta-microseminoprotein ) a secretory protein specifically expressed and synthesized in the lateral lobe of the rat prostate?
### Response:
| Rat PSP94 is a major secretory protein highly expressed and synthesized by the lateral lobe of both rat and mouse prostate glands, and moderately expressed in the dorsal lobe of the rat prostate gland. |
### Instruction:
Is prostatic involution in men taking finasteride associated with elevated levels of insulin-like growth factor-binding proteins ( IGFBPs ) -2 , -4 , and -5?
### Response:
| These results indicate that IGFBP-2, -4, and -5 are associated with prostatic involution. Because of the timing and distribution of expression, we hypothesize that IGFBP-2 and -4 have a role as signals for apoptosis, but that IGFBP-5 likely does not. |
### Instruction:
Is mitochondrial aconitase gene expression regulated by testosterone and prolactin in prostate epithelial cells?
### Response:
| In addition to the constitutive expression of m-aconitase, the m-aconitase gene is testosterone- and prolactin-regulated in specifically targeted prostate cells. The hormonal regulation of m-aconitase gene expression and biosynthesis of m-aconitase provide a regulatory mechanism for the oxidation of citrate, and conseq... |
### Instruction:
Does interleukin-6 induce prostate cancer cell growth accompanied by activation of stat3 signaling pathway?
### Response:
| IL-6 is an autocrine growth factor for LNCaP human prostate cancer cells; the effects of IL-6 on prostate cancer cell growth are mediated through the Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway. |
### Instruction:
Does combination therapy using prednisolone and cyclophosphamide slow the progression of moderately advanced IgA nephropathy?
### Response:
| We suggest that the immunosuppressive treatment with CPA is sometimes necessary to preserve renal function in patients with histologically advanced IgAN. |
### Instruction:
Does plaque morphology correlate with cerebrovascular symptoms in patients with complex aortic arch plaque?
### Response:
| Transcutaneous B-mode ultrasonography of the aortic arch can help to identify heterogeneous plaques that are more likely to be associated with ischemic stroke using morphological criteria derived from studies of carotid artery plaque. |
### Instruction:
Does a 12-hour urine collection accurately assess proteinuria in the hospitalized hypertensive gravida?
### Response:
| A 12-hour urine collection accurately depicts the amount of proteinuria in hospitalized gravidas being evaluated for preeclampsia. |
### Instruction:
Does magnesium citrate-bisacodyl regimen prove better than castor oil for colonoscopic preparation?
### Response:
| A combined oral magnesium citrate and bisacodyl regimen is effective and better than castor oil for colonoscopic preparation. |
### Instruction:
Does early wound healing exhibit cytokine surge without evidence of hypoxia?
### Response:
| Induction of angiogenic cytokines early during wound healing may be due to triggering mechanisms other than hypoxia. Alternatively, the unique pattern of development and decline of cellular hypoxia as wound cellularity and proliferation regress suggest its involvement in initiating vascular regression during the later ... |
### Instruction:
Is androgen receptor expression greater in macrophages from male than from female donors . A sex difference with implications for atherogenesis?
### Response:
| Sex differences in androgen-mediated macrophage lipid loading may contribute to the greater prevalence and severity of atherosclerosis in men. |
### Instruction:
Is enteroviral capsid protein VP1 present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy?
### Response:
| Our findings demonstrate a direct link between enterovirus infection and some myocarditis or DCM cases. The pattern of VP1 detection may correlate with disease stage and severity. The data suggest that viral protein synthesis may be involved in persistent enterovirus infection in the pathogenesis of DCM. |
### Instruction:
Does substance P cause a chloride-dependent short-circuit current response in rabbit colonic mucosa in vitro?
### Response:
| SP stimulates a chloride-dependent Isc increase in the rabbit colon which is mediated by nerves and mast cells and the mast cell product histamine. |
### Instruction:
Is granulocyte marker protein increased in stools from rats with azoxymethane-induced colon cancer?
### Response:
| Fecal GMP may have provided us with a valuable tool for further studies of the induction and progression of neoplasia in rats and, possibly, in mice, since the anti-GMP antibody cross-reacts with feces extracts from mice. |
### Instruction:
Do impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels?
### Response:
| The levels of induced TGF-beta1 and TGF-beta1 m-RNA after L burn injury are higher and peak earlier than after M burn injury. Elevated TGF-beta1 may be associated with cell death in hepatocytes. The TGF-beta1 rise may be associated with hepatocyte injury and systemic response to massive burn. |
### Instruction:
Does troglitazone reduce hyperglycaemia and selectively acute-phase serum proteins in patients with Type II diabetes?
### Response:
| In Type II diabetic patients serum amyloid A and complement protein C3 are raised. Troglitazone exerts a selective reversible action on some acute-phase proteins and C3 but not on others in conjunction with the improvement in glucose metabolism. |
### Instruction:
Does angiotensin converting-enzyme inhibitor treatment reduce glomerular p16INK4 and p27Kip1 expression in diabetic BBdp rats?
### Response:
| Our data show that enalapril attenuates the glomerular expression of cyclin-dependent kinase inhibitors in diabetes and suggest a molecular mechanism of how angiotensin-converting enzyme inhibitors prevent renal hypertrophy in diabetes. |
### Instruction:
Does induction of glycation suppress glucokinase gene expression in HIT-T15 cells?
### Response:
| The induction of the glycation reaction, which is known to occur in pancreatic beta cells in chronic hyperglycaemia, suppresses the glucokinase gene transcription and its enzymatic activity. Thus, hyperglycaemia-dependent inhibition of glucokinase activity could in part explain beta-cell glucose toxicity. |
### Instruction:
Is eLISA the superior method for detecting antineutrophil cytoplasmic antibodies in the diagnosis of systemic necrotising vasculitis?
### Response:
| ELISA is the superior method of ANCA detection in the diagnosis of systemic necrotising vasculitis and should be used in conjunction with a compatible clinical picture and histological evidence. |
### Instruction:
Do precision of CNC-milled titanium frameworks for implant treatment in the edentulous jaw?
### Response:
| The precision of fit of the first CNC-milled prostheses presented a comparable fit to the conventional cast frameworks. Consequently, this new technique could be a valid option for the routine fabrication of frameworks for implant prostheses. |
### Instruction:
Does expression of a single pair of desmosomal glycoproteins render the corneal epithelium unique amongst stratified epithelia?
### Response:
| Uniquely among stratified epithelia, cornea expresses only a single pair of desmosomal glycoproteins, Dsc2 and Dsg2. Expression of Dsc3 and Dsg3 in limbus and conjunctiva coincides with their association with cell proliferation in other epithelia, but corneal epithelial cells did not express Dsc3 or Dsg3 during re-epit... |
### Instruction:
Does sufentanil prolong the duration of analgesia in a mepivacaine brachial plexus block : a dose response study?
### Response:
| This study demonstrates that the addition of sufentanil in a dose-dependent manner to 1.5% mepivacaine in the axillary plexus does not improve onset or duration of blockade, and that this admixture is associated with an increased incidence of side effects. |
### Instruction:
Is length rather than a specific allele of dinucleotide repeat in the 5 ' upstream region of the aldose reductase gene associated with diabetic retinopathy?
### Response:
| (CA)n repeat length, rather than a specific allele, in the 5' upstream region of the AR gene is associated with diabetic retinopathy. These data suggest that the AR locus plays a role in genetic susceptibility to diabetic retinopathy and that dinucleotide repeats in genomic DNA may be related to disease predisposition. |
### Instruction:
Does nitric oxide prevent p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells?
### Response:
| These data indicate that one mechanism by which NO upregulates p21 protein expression is through the prevention of p21 protein degradation by the ubiquitin-proteasome pathway in association with increased protein tyrosine and serine/threonine phosphatase activity. |
### Instruction:
Does p27 expression correlate with prognosis in patients with hypopharyngeal cancer?
### Response:
| The immunohistochemical analysis of p27 provides a possible tool in determining the prognosis of patients with hypopharyngeal cancer. |
### Instruction:
Is hypoalbuminemia a poor predictor of survival after percutaneous endoscopic gastrostomy in elderly patients with dementia?
### Response:
| Only 50% of demented patients with inadequate oral intake are likely to survive beyond 6 months after PEG placement. No improvement in performance status is likely to occur in any patient. These limited benefits should be realized before initiating PEG feeding. Since the survival in the age-matched control group with a... |
### Instruction:
Are serum levels of connective tissue growth factor elevated in patients with systemic sclerosis : association with extent of skin sclerosis and severity of pulmonary fibrosis?
### Response:
| Serum CTGF levels were increased in patients with SSc, and correlated with the extent of skin sclerosis and the severity of pulmonary fibrosis. In addition, it appears that production of CTGF is involved in the development or maintenance of fibrosis rather than in initiation of fibrosis in SSc. These data suggest that ... |
### Instruction:
Is lMP2 polymorphism associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis?
### Response:
| HLA Class II encoded genes may have effects on disease susceptibility and/or phenotype in HLA-B27 negative individuals similar to those noted in HLA-B27 positive AS. Eccentric and axial phenotypes of disease may be immunogenetically determined. |
### Instruction:
Does increased intensity of a single exercise bout stimulate subsequent fat intake?
### Response:
| The present study shows that changing the type of activity of a single exercise bout from 30% of maximal aerobic capacity for 60 min to 60% for only 30 min resulted in consumption of a diet the following day with a higher fat energy percentage compared with the diet selected after the low-intensity exercise. However, t... |
### Instruction:
Is severe anemia associated with poor tumor oxygenation in head and neck squamous cell carcinomas?
### Response:
| Our data suggest that a low Hb concentration and cigarette smoking contribute to inadequate oxygenation of SCCHN and thus for increased radioresistance. Consequently, Hb correction and abstinence from smoking may significantly improve tumor oxygenation. |
### Instruction:
Do [ Characterization and biological significance of peripheral blood dendritic cell subsets in patients with severe burn ]?
### Response:
| The functions of DCs in the patients with severe burn are declined, which may partly contribute to infection after burn. |
### Instruction:
Is immediate CEA for symptomatic carotid disease preferably performed under local anaesthesia safe?
### Response:
| It seems that patients with a symptomatic high-grade ICA stenosis can undergo CEA particularly under local anaesthesia as soon as possible without anticipating an increased complication rate. |
### Instruction:
Does intravenous nicorandil preserve endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel?
### Response:
| The beneficial effect of nicorandil on endothelial junctions could be due to its effect on ET-1 via the activation of KATp channel. |
### Instruction:
Do n-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex?
### Response:
| The present findings suggest that abnormal increased synchronization in ongoing gamma oscillations in cortical-related networks might cause dysfunctions of conscious integration, as seen in patients with schizophrenia. |
### Instruction:
Is hemodialysis-induced cardiac dysfunction associated with an acute reduction in global and segmental myocardial blood flow?
### Response:
| Hemodialysis is associated with repetitive myocardial ischemia, which, in the absence of coronary artery disease, may be due to coronary microvascular dysfunction. Stress-induced segmental left ventricular dysfunction correlates with matched reduction in MBF. Functional poststress recovery is consistent with myocardial... |
### Instruction:
Does early experience show rapid shrinking of abdominal aortic aneurysms after endovascular treatment with Anaconda device?
### Response:
| Early results show that he Anaconda endovascular device for aneurysm repair is a safe and effective device for patients with suitable abdominal aortic aneurysms and proper distal access vessels which results in significant aneurysm diameter decrease and a low complication rate after 6 months of follow-up. |
### Instruction:
Does vitreous fluid of db/db mice exhibit alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy?
### Response:
| The findings support the potential usefulness of vitreous from the db/db mouse as a model tissue for investigation of pathogenetic factors and assessment of therapeutic interventions in early diabetic retinopathy. |
### Instruction:
Does total fundoplication obstruct the esophageal secondary peristalsis : investigation with pre- and postoperative 24-hour pH-multichannel intraluminal impedance?
### Response:
| In this study total fundoplication did not affect the BCT by combined 24-hour ph monitoring and multichannel intraluminal impedance. |
### Instruction:
Does anticancer effect of aloe-emodin on cervical cancer cells involve G2/M arrest and induction of differentiation?
### Response:
| These findings provide a possible mechanistic explanation for the growth inhibitory effect of aloe-emodin on HeLa, which includes cell cycle arrest and inducing differentiation. |
### Instruction:
Does trichosanthes kirilowii tuber extract induce G2/M phase arrest via inhibition of tubulin polymerization in HepG2 cells?
### Response:
| Anticancer mechanisms of TKE linked to the inhibition of tubulin polymerization, through which it exerts cell cycle arrest at the G2/M phase in the HepG2 cell line. |
### Instruction:
Do inhibitors of protein kinase C sensitise multiple myeloma cells to common genotoxic drugs?
### Response:
| We conclude that the combination of conventional drugs and PKC inhibitors might be very effective and represents a new strategy in the treatment of MM. |
### Instruction:
Does c-reactive protein correlate with bacterial load and appropriate antibiotic therapy in suspected ventilator-associated pneumonia?
### Response:
| C-reactive protein is a useful biochemical surrogate of bacterial burden in patients with ventilator-associated pneumonia. Follow-up measurements of serum C-reactive protein anticipate the appropriateness of antibiotic therapy. |
### Instruction:
Does duffy antigen modify the chemokine response in human endotoxemia?
### Response:
| The Duffy antigen substantially alters chemokine concentrations in blood, but it does not have a protective effect during human endotoxemia. |
### Instruction:
Does low selenium status affect arsenic metabolites in an arsenic exposed population with skin lesions?
### Response:
| Lower serum selenium status (<50 microg/l) is significantly correlated to the arsenic-associated skin lesions in the arsenic exposed population. The accumulation of iAs and its inhibition to be biotransformed to DMA occurred in human due to chronic exposure of low selenium status. |
### Instruction:
Does leptin signalling reduce the severity of cardiac dysfunction and remodelling after chronic ischaemic injury?
### Response:
| These data demonstrate that HF increases ObR signalling in cardiomyocytes and that activation of ObR signalling improves functional outcomes in chronic ischaemic injury leading to HF. |
### Instruction:
Does preconditioning enhance cell survival and differentiation of stem cells during transplantation in infarcted myocardium?
### Response:
| We conclude that PC with the chemokine SDF-1 suppresses MSCs apoptosis, enhances their survival, engraftment, and vascular density, and improves myocardial function via SDF/CXCR4 signaling. Chemokine PC is a novel approach for enhancing stem cell survival and regeneration of infarcted myocardium. |
### Instruction:
Does adoption of lower tidal volume ventilation improve with feedback and education?
### Response:
| Adoption of a lower-V(T) ventilation strategy in patients with acute lung injury or acute respiratory distress syndrome is far from complete in the Netherlands. Adoption of a lower-V(T) strategy improves after feedback and education. |
### Instruction:
Do morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF?
### Response:
| Because INK4a/ARF promoter hypermethylation does not increase with age but increases with the frequency of other methylation events, we predict that INK4a/ARF promoter hypermethylation may serve as a marker of global methylation dysregulation. |
### Instruction:
Is glu298Asp polymorphism of the eNOS gene associated with coronary collateral development?
### Response:
| The present study suggests that the Asp298 allele of the eNOS gene is significantly associated with impaired collateral development, especially in patients with diabetes mellitus. Treatment strategies that modulate eNOS activity and/or NO production may improve coronary collateral development. |
### Instruction:
Does tTM-based motivational counselling increase physical activity of low back pain patients in a primary care setting -- A cluster-randomized controlled trial?
### Response:
| The outcome may be explained by insufficient performance of the practice nurses, implementation barriers caused by the German health care system and the heterogenous sample. |
### Instruction:
Does simvastatin reverse high glucose-induced apoptosis of mesangial cells via modulation of Wnt signaling pathway?
### Response:
| SIM reduces the detrimental effects of HG on diabetic renal glomeruli in vitro and in vivo. SIM prevents HG-induced downregulation of Wnt/beta-catenin signaling and thereby blocks mesangial cell apoptosis. |
### Instruction:
Do dynamic contrast enhancement patterns of solitary pulmonary nodules on 3D gradient-recalled echo MRI?
### Response:
| Rim contrast enhancement is highly valuable in the diagnosis of tuberculoma. Time-intensity curve types can be taken into consideration for noninvasive differentiation of lung cancer, tuberculoma, and round atelectasis. |
### Instruction:
Does one size fit all : the need for a continuous measure for glycemic control in diabetes?
### Response:
| A continuous measure of A1C can better capture than a dichotomous measure the complexity of glycemic control at a population level. |
### Instruction:
Do troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy?
### Response:
| Evaluation of the impact of the mutations on cardiac structure and function in prehypertrophic mutation-carriers, relative to the baseline norm provided by their non-carrier family members, best recapitulated existing animal and in vitro functional data, while inclusion of mutation-carriers with hypertrophy obscured su... |
### Instruction:
Does eMAP-II downregulation contribute to the beneficial effects of rapamycin after vascular injury?
### Response:
| These data suggest important yet unrecognized roles of EMAP-II and adventitial inflammation in neointima formation: Through inhibition of EMAP-II, rapamycin reduces the recruitment of inflammatory cells to the adventitia and supports an early and bland healing. |
### Instruction:
Does temporal summation of pain characterize women but not men with temporomandibular disorders?
### Response:
| These findings suggest that central nociceptive processing upregulation is likely to contribute to TMD pain for women but is not a factor for |
### Instruction:
Is visceral fat associated with cardiovascular risk in women with polycystic ovary syndrome?
### Response:
| VF amount is associated with subclinical CVD in PCOS patients. |
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