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### Instruction:
Does mR pharmacokinetic modeling of the patellar cartilage differentiate normal from pathological conditions?
### Response:
| The vascular permeability and EES fraction of cartilage increases with the severity of the degeneration. Pharmacokinetic models allow to study the vascular properties of the cartilage and may have applications as a surrogate index in longitudinal studies to quantify the evolution of drug trials. |
### Instruction:
Are putative zinc finger protein binding sites over-represented in the boundaries of methylation-resistant CpG islands in the human genome?
### Response:
| Our results suggest a possible mechanism that certain putative zinc finger protein binding sites over-represented in the boundary regions of the methylation-resistant CpG islands may block the spreading of methylation into these islands, and those TFBSs over-represented within the islands may both reinforce the methyla... |
### Instruction:
Is aprotinin safe in pediatric patients undergoing cardiac surgery?
### Response:
| In this retrospective cohort study of pediatric patients undergoing cardiopulmonary bypass, there was no association between the use of aprotinin and acute kidney failure, need for dialysis, neurologic complications, and operative or late mortality. We continue to use aprotinin for all pediatric patients undergoing car... |
### Instruction:
Is ankle osteoarthritis associated with knee osteoarthritis . Conclusions based on mechanical axis radiographs?
### Response:
| Ankle OA and tilt were not uncommon in our patients with knee OA. The assumption that associations may exist between knee and ankle OA and joint malalignment was confirmed. |
### Instruction:
Is switching to long-acting injectable risperidone beneficial with regard to clinical outcomes , regardless of previous conventional medication in patients with schizophrenia?
### Response:
| Patients with schizophrenia, unsatisfactorily treated with oral or depot conventional antipsychotics, showed improvement in symptom control, tolerability, and patient satisfaction after switching to RLAI. |
### Instruction:
Does liver function test result predict nutritional status evaluated by arm anthropometric indicators?
### Response:
| The data presented underline the correlation between the liver damage severity evaluated by LFT and the nutritional status estimated by anthropometric indicators. In our view these observations reflect the close relationship between liver function and the degree of liver damage to growth and current nutritional status. |
### Instruction:
Is genetic diversity at the UGT1 locus amplified by a novel 3 ' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity?
### Response:
| The UGT1A isoforms 2 act as negative modulators of their isoform 1 homologs in microsome preparations, revealing a new regulatory mechanism of the glucuronidation pathway. Findings further provide the first direct evidence of a novel alternative splicing mechanism at the 3' end of the UGT1 locus that further increases ... |
### Instruction:
Are plasmacytoid dendritic cells present in cutaneous dermatomyositis lesions in a pattern distinct from lupus erythematosus?
### Response:
| Skin lesions of DM contain PDCs. Because PDCs are thought to participate in the pathogenesis of LE, this finding suggests that they may play a role in DM as well. The preferential epidermal localization of PDCs in DM suggests that their contribution to disease pathogenesis or maintenance in DM may be distinct from LE. ... |
### Instruction:
Do south Asian men have different patterns of coronary artery disease when compared with European men?
### Response:
| Increased LAD stenosis, despite equivalent levels of calcified disease, in South Asians is attributable to narrower arteries. Reduced LAD diameter is associated with advanced disease in Europeans but not in South Asians, indicative of ethnic differences in vascular remodelling. |
### Instruction:
Does targeting of phospholamban by peroxynitrite decrease beta-adrenergic stimulation in cardiomyocytes?
### Response:
| The peroxynitrite donor SIN-1 decreases beta-adrenergic stimulation by reducing PLB(Ser16) phosphorylation via protein phosphatase activation. This peroxynitrite-induced decrease in PLB phosphorylation may be a key mechanism in the beta-adrenergic dysfunction observed in many cardiomyopathies. |
### Instruction:
Does shear stress-induced activation of the AMP-activated protein kinase regulate FoxO1a and angiopoietin-2 in endothelial cells?
### Response:
| These data indicate that the AMPK activated by fluid shear stress is a novel regulator of FoxO1a phosphorylation and protein levels. Moreover, as the AMPK-dependent phosphorylation and degradation of FoxO1a attenuates Ang-2 expression and protects against the pro-inflammatory actions of TNF-alpha, this kinase may be a ... |
### Instruction:
Does chronic angiotensin IV treatment reverse endothelial dysfunction in ApoE-deficient mice?
### Response:
| Chronic angiotensin IV treatment in ApoE-/- mice evoked a marked vasoprotective effect that appeared to be mediated by improved NO bioavailability as a result of AT4 and/or AT2 receptor stimulation. |
### Instruction:
Does leptin-induced cardiomyocyte hypertrophy involve selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei?
### Response:
| Our results indicate that p38 import into nuclei represents a key mechanism for leptin-induced hypertrophy acting through lipid raft/caveolae and a RhoA-dependent pathway. |
### Instruction:
Does sarcalumenin alleviate stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum?
### Response:
| These findings suggest that functional interaction between SAR and SERCA2a enhances protein stability of SERCA2a and facilitates Ca(2+) sequestration into the SR. Thus the SAR-SERCA2a interaction plays an essential role in preserving cardiac function under biomechanical stresses such as pressure overload. |
### Instruction:
Does [ Replacement of third-generation cephalosporins by piperacillin-tazobactam decrease colonization of extended-spectrum beta-lactamases-producing intestinal Escherichia coli ]?
### Response:
| Replacement of third-generation cephalosporin with pip-tazo can reduce colonization of ESBLs--producing E. coli in intestinal tract. |
### Instruction:
Is expression of cell cycle regulator p16 affected by diabetes during oral oncogenesis?
### Response:
| It seems that the expression of cell cycle regulator p16 is not affected by diabetes in the studied animal model of oral oncogenesis. |
### Instruction:
Is laparoscopic appendectomy superior to open appendectomy in obese patients?
### Response:
| LA is associated with shorter lengths of stay, fewer open wounds, and equivalent hospital charges and intra-abdominal abscess rates; and should be considered the procedure of choice for obese patients with appendicitis. |
### Instruction:
Is solitary positive sentinel lymph node accompanied by negative sentinel lymph node ( s ) predictive of a negative completion axillary lymph node dissection?
### Response:
| A solitary positive SLN accompanied by additional negative SLN(s) is predictive of a negative completion ALND. |
### Instruction:
Does laparoscopic unroofing of splenic cysts result in a high rate of recurrences?
### Response:
| Laparoscopic unroofing of true splenic cysts alone proved inadequate in this series. Either removal of the inner layer or partial splenectomy appears to be necessary to prevent recurrences. |
### Instruction:
Does age-related HMG-CoA reductase deregulation depend on ROS-induced p38 activation?
### Response:
| Our data show that the hepatic HMG-CoAR is completely dephosphorylated in the liver of old rat being the PP2A increased association with HMG-CoAR the main responsible. On the other hand, the age-related greater association between PP2A and HMG-CoAR results to be due to an increase in ROS that is present during aging an... |
### Instruction:
Does [ Matrix metalloproteinases inhibitor doxycycline inhibit TGF-beta 1-induced RPE cell migration ]?
### Response:
| This study indicates that Doxycycline can inhibit migration of RPE cells stimulated by TGF-beta 1. RPE migration induced by TGF-beta 1 may act partially through the stimulation of MMP production. |
### Instruction:
Do [ Establishment of human retinoblastoma model in human immune reconstruction non-obese diabetic-severe combine immunodeficient mice ]?
### Response:
| The RB model in the human PBL NOD-SCID mice has been successfully established, which simulates the biological behavior of human spontaneous RB. This model may be useful for the studying of immune regression and immunotherapy of human RB. |
### Instruction:
Does the transient expression of mRNA coding for Rep protein from AAV facilitate targeted plasmid integration?
### Response:
| These results demonstrate that transient expression of Rep protein using transfected mRNA facilitates site-specific integration of plasmid DNA. This approach allows expression of Rep for only a short time, and may circumvent the toxicity and chromosome instability associated with long-term expression of Rep. |
### Instruction:
Does sELDI-TOF MS whole serum proteomic profiling with IMAC surface reliably detect prostate cancer?
### Response:
| In this, the 2nd stage of our planned validation process, the SELDI-TOF MS-based protein expression profiling approach did not perform well enough to advance to the 3rd (prospective study) stage. We conclude that the results from our previous studies-in which differentiation between prostate cancer and noncancer was de... |
### Instruction:
Does progressive caloric restriction induce dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men?
### Response:
| Progressive caloric restriction induces a dose-dependent increase in myocardial TG content and a dose-dependent decrease in diastolic function in lean healthy men. Hepatic TG content showed a differential response to progressive caloric restriction, indicating that redistribution of endogenous TG stores is tissue speci... |
### Instruction:
Does cerebrocortical beta activity in overweight humans respond to insulin detemir?
### Response:
| Despite cerebrocortical resistance to human insulin, insulin detemir increased beta activity in overweight human subjects similarly as human insulin in lean subjects. These data suggest that the decreased cerebral beta activity response in overweight subjects can be restored by insulin detemir. |
### Instruction:
Are endoscopic biopsy diagnosis of acute gastrointestinal graft-versus-host disease : rectosigmoid biopsies more sensitive than upper gastrointestinal biopsies?
### Response:
| Biopsy of the rectosigmoid is the single best test for diagnosing GI GVHD. |
### Instruction:
Does k-CL co-transport play an important role in normal and beta thalassemic erythropoiesis?
### Response:
| Ineffective erythropoiesis of in vitro cultured beta-thalassemic cells is likely related to impaired cell maturation. KCC activity appears to contribute to erythroid cell growth during late erythropoiesis. |
### Instruction:
Are duplications in addition to terminal deletions present in a proportion of ring chromosomes : clues to the mechanisms of formation?
### Response:
| Inv dup del rearrangements have been reported for several chromosomes, but hardly ever in ring chromosomes. Our findings highlight a new mechanism for the formation of some ring chromosomes and show that inv dup del rearrangements may be stabilised not only through telomere healing and telomere capture but also through... |
### Instruction:
Does colonization of peanut roots by biofilm-forming Paenibacillus polymyxa initiate biocontrol against crown rot disease?
### Response:
| Both strains were able to suppress the pathogen but the superior biofilm former offers significantly better protection against crown rot. |
### Instruction:
Are antibodies to Escherichia coli outer membrane porin C in the absence of anti-Saccharomyces cerevisiae antibodies and anti-neutrophil cytoplasmic antibodies an unreliable marker of Crohn disease and ulcerative colitis?
### Response:
| Anti-OmpC, in the absence of ASCA and ANCA, is a serological pattern noted in a subset of medically complex cases in children and young adults without CD or UC. |
### Instruction:
Do plasma MMP-2-TIMP-2 complex levels measured during follow-up predict a risk of relapse in patients with malignant lymphoma?
### Response:
| This study shows that lymphoma patients with the highest levels of MMP-2-TIMP-2 complex are at a marked risk of relapse. Moreover, plasma levels of MMP-2-TIMP-2 complex, proMMP-2, TIMP-2, and proMMP-2/TIMP-2 ratio are at abnormal level in patients with newly diagnosed lymphoma and those in remission when compared to he... |
### Instruction:
Does activation of p53 stimulate proteasome-dependent truncation of eIF4E-binding protein 1 ( 4E-BP1 )?
### Response:
| The results suggest a model in which proteasome activity gives rise to a stable, hypophosphorylated and truncated form of 4E-BP1, which may exert a long-term inhibitory effect on the availability of eIF4E, thus contributing to the inhibition of protein synthesis and the growth-inhibitory and pro-apoptotic effects of p5... |
### Instruction:
Is the bone morphogenetic protein pathway active in human colon adenomas and inactivated in colorectal cancer?
### Response:
| Taken together, the current results indicated that loss of BMP signaling correlates tightly with progression of adenomas to cancer and occurs relatively early during cancer progression. |
### Instruction:
Does matrix metalloproteinase inhibition protect rat livers from prolonged cold ischemia-warm reperfusion injury?
### Response:
| These data demonstrate that MMPs, by altering the ECM, play a major role in liver CI-WR injury leading to extensive hepatocyte necrosis and that their inhibition might prove to be a new strategy in improving preservation solutions. |
### Instruction:
Does the level of matrix metalloproteinase-2 in donor plasma strongly correlate with post-transfusion recovery of stored platelet concentrates?
### Response:
| These observations suggest that pre-transfusion MMP-2 assay of donor's plasma may be a predictor of post-transfusion recovery of PCs. However, the usefulness of this assay should be elucidated in clinical transfusion settings. |
### Instruction:
Does a promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predict poor prognosis in esophageal squamous cell carcinoma?
### Response:
| NMDAR2B promoter methylation could be a clinically applicable marker in ESCC. |
### Instruction:
Does gain of 5p15.33 is associate with progression of bladder cancer?
### Response:
| These data suggest that gain of 5p15.33 (TPPP and ZDHHC11) may become a potential biomarker identifying high-risk patients with disease progression in bladder cancer. |
### Instruction:
Does exogenously-administered leptin increase early incisional wound angiogenesis in an experimental animal model?
### Response:
| Exogenous administration of leptin may increase early tissue angiogenesis in the incisional wound of an experimental animal model. |
### Instruction:
Do eGFR and c-Jun exhibit the same pattern of expression and increase gradually during the progress of oral oncogenesis?
### Response:
| Since EGFR and c-Jun are implicated in the same molecular pathway of signal transduction, it may be assumed that an increase in EGFR levels leads to increased activation of phospholipase Cy signal transduction cascade, which in turn activates c-Jun protein. Therefore, c-Jun expression in oral cancer seems to be increas... |
### Instruction:
Does adenosine increase calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries?
### Response:
| The study shows that Ado activates the p38 MAPK/MK2 pathway in vascular smooth muscle via an intracellular action, which results in an increased MLC(20) phosphorylation in concert with increased calcium sensitivity of the contractile apparatus. This mechanism can significantly contribute to the regulation of vascular t... |
### Instruction:
Does computer-assisted intervention improve patient-centered diabetes care by increasing autonomy support?
### Response:
| A patient-centered, computer-assisted intervention was effective in improving diabetes self-management outcomes, in part, because it increased patients' perception that their autonomy was supported which changed perceived competence. These findings support the self-determination model for health behavior change and the... |
### Instruction:
Does parental nativity affect children 's health and access to care?
### Response:
| Efforts to improve children of immigrants' health and access to care should focus on families in which both parents are immigrants, particularly those who are ethnic or racial minorities. Efforts to increase use of health services should focus on non-citizen children. |
### Instruction:
Do bone marrow-derived progenitor cells contribute to lung remodelling after myocardial infarction?
### Response:
| After MI, bone marrow-derived progenitor differentiates into lung MFs. This novel pathophysiologic process may contribute to the pulmonary manifestations of CHF and could have significant therapeutic implications. |
### Instruction:
Does cpG island hypermethylation in cell-free serum DNA identify patients with localized prostate cancer?
### Response:
| The detection of aberrant hypermethylation in cell-free serum DNA allows the highly specific diagnosis of PCA. A test based on GSTP1 hypermethylation in serum samples of patients with suspected PCA may help to identify men with increased risk of harboring PCA despite negative prostate biopsy. |
### Instruction:
Does the [ FeFe ] hydrogenase of Nyctotherus ovalis have a chimeric origin?
### Response:
| The hydrogenase and their associated modules have most likely been acquired by independent lateral gene transfer from different sources. This scenario for a concerted lateral gene transfer is in agreement with the evolution of the hydrogenosome from a genuine ciliate mitochondrion by evolutionary tinkering. |
### Instruction:
Is androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines regulated through two different isoforms of acyl-coenzyme A : Cholesterol Acyltransferase ( ACAT )?
### Response:
| Overall, these findings support the importance of cholesterol metabolism regulation within prostate cancer cells and unravel a novel role for STAT1 alpha in prostate cancer metabolism. |
### Instruction:
Does epinephrine concentration ( 1:100,000 or 1:200,000 ) affect the clinical efficacy of 4 % articaine for lower third molar removal : a double-blind , randomized , crossover study?
### Response:
| An epinephrine concentration of 1:100,000 or 1:200,000 in 4% articaine solution does not affect the clinical efficacy of this local anesthetic. It is possible to successfully use the 4% articaine formulation with a lower concentration of epinephrine (1:200,000 or 5 mug/mL) for lower third molar extraction with or witho... |
### Instruction:
Are variations in metabolic response to TPN influenced more by sex than by light exposure?
### Response:
| These results demonstrate that sex-related differences in nitrogen/protein metabolism reported during enteral nutrition are seen during TPN as well. Sex is an important variable that will need to be taken into account in future studies evaluating the potential clinical effects of photo-protecting TPN. |
### Instruction:
Does bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuate allergic airway disease in mice?
### Response:
| Milk fat enriched in conjugated linoleic and VAs suppresses inflammation and changes to the airways in an animal model of allergic airway disease. |
### Instruction:
Is nAT2 6A , a haplotype of the N-acetyltransferase 2 gene , an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis?
### Response:
| The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2 4 and NAT2 6A, are useful new biomarkers for predicting anti-TB drug-induced hepatotoxicity. |
### Instruction:
Do multiple biomarkers improve prediction of bladder cancer recurrence and mortality in patients undergoing cystectomy?
### Response:
| Assessment of the number of altered biomarkers in the cystectomy specimen improves the prediction of bladder cancer recurrence and survival in patients with pTa-3N0M0 disease. Prospective evaluation of alteration in these biomarkers can help identify patients who would benefit from adjuvant treatment after radical cyst... |
### Instruction:
Does vertical retrocolic duodenojejunostomy decrease delayed gastric emptying after pylorus-preserving pancreatoduodenectomy?
### Response:
| The current reconstruction method may minimize DGE after PPPD. |
### Instruction:
Is gasless laparoscopy-assisted distal gastrectomy feasible and useful for non-obese patients with early gastric cancer?
### Response:
| Gasless laparoscopy-assisted distal gastrectomy is feasible and useful for early gastric cancer except when treating obese patients. |
### Instruction:
Does poststroke cerebral peduncular atrophy correlate with a measure of corticospinal tract injury in the cerebral hemisphere?
### Response:
| The extent of postinfarction CST injury in the cerebral hemisphere predicts the extent of ipsilateral cerebral peduncular atrophy. More generally, the findings suggest that the extent of remote wallerian degeneration of a fiber tract is strongly related to its extent of injury directly at the site of infarction. |
### Instruction:
Does chlamydophila pneumoniae induce a sustained airway hyperresponsiveness and inflammation in mice?
### Response:
| Our study demonstrates for the first time that C. pneumoniae infection can modify bronchial responsiveness. This has clinical implications, since additional changes in airway responsiveness and inflammation-status induced by this bacterium may worsen and/or provoke breathlessness in asthma and COPD. |
### Instruction:
Are agents blocking the nuclear factor-kappaB pathway effective inhibitors of endometriosis in an in vivo experimental model?
### Response:
| This study demonstrates, for the first time, that the NF-kappaB pathway is implicated in the development of endometriotic lesions in vivo and that NF-kappaB inhibition reduces ICAM-1 expression and cell proliferation, but increases apoptosis of endometriotic lesions, diminishing the initial development of endometriosis... |
### Instruction:
Do mutuality and preparedness moderate the effects of caregiving demand on cancer family caregiver outcomes?
### Response:
| Analysis of three-way interactions provided new theoretical insights into the protective effects of mutuality and preparedness and demonstrated conditions under which caregivers are at increased risk for negative outcomes. |
### Instruction:
Does polyglycolic acid glue prevent intrapericardial adhesions in a short-term follow-up?
### Response:
| The DuraSeal polyglycolic acid glue did not reduce the development of pericardial adhesions in pigs. |
### Instruction:
Are c4D deposition and positive posttransplant crossmatch necessarily markers of antibody-mediated rejection in renal allograft recipients?
### Response:
| C4d and a positive posttransplant crossmatch were not associated with histologic features of AMR in half of the ARE. Nevertheless, C4d deposition and positive posttransplant crossmatches correlated with allograft injury among renal transplant patients. |
### Instruction:
Does a mycoplasma peptide elicit heteroclitic CD4+ T cell responses against tumor antigen MAGE-A6?
### Response:
| We believe that these novel "promiscuous" MAGE-A6/MPHF2 Th epitopes may prove clinically useful in the treatment and/or monitoring of a high proportion of cancer patients. |
### Instruction:
Do hLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap?
### Response:
| We present clinical data, HLA genotyping and serological profiling on a large cohort of JDM patients and a carefully characterized subset of patients with JDM-SSc overlap. The results confirm known HLA associations and extend the knowledge by stratification of data in serological and clinical subgroups. In the future, ... |
### Instruction:
Does amygdala and ventral anterior cingulate activation predict treatment response to cognitive behaviour therapy for post-traumatic stress disorder?
### Response:
| Excessive fear responses in response to fear-eliciting stimuli may be a key factor in limiting responses to CBT for PTSD. This excessive amygdala response to fear may reflect difficulty in managing anxiety reactions elicited during CBT, and this factor may limit optimal response to therapy. |
### Instruction:
Is cannabis abuse associated with decision-making impairment among first-episode patients with schizophrenia-spectrum psychosis?
### Response:
| Pre-psychotic cannabis abuse is associated with decision-making impairment, but not working memory and executive function impairment, among first-episode patients with a schizophrenia-spectrum psychosis. Further studies are needed to examine the direction of causality of this impairment; that is, does the impairment ma... |
### Instruction:
Does thyroid hormone regulate the expression and function of P-glycoprotein in Caco-2 cells?
### Response:
| These results indicate that T(3) regulates the expression and function of Pgp. It is possible that changes in Pgp expression alter the pharmacokinetics of Pgp substrates in patients with thyroid disorders. |
### Instruction:
Is increased risk of death associated with hypotension altered by the presence of brain injury in pediatric trauma patients?
### Response:
| Hypotension is an important predictor of death in pediatric trauma patients. The increased risk of death associated with hypotension is similar with or without traumatic brain injury. |
### Instruction:
Does a non-allogeneic stimulus trigger the production of de novo HLA antibodies in healthy adults?
### Response:
| The findings of this study demonstrate that a non-HLA antigenic stimulus is capable of eliciting the development of HLA antibodies in healthy adults. |
### Instruction:
Does glutathione supplementation to University of Wisconsin solution cause endothelial dysfunction?
### Response:
| GSH supplementation of UW solution exacerbates cold-ischaemia induced endothelial dysfunction. GSNO did not share the detrimental effects of GSH and promoted NO-mediated vasodilatation. |
### Instruction:
Is in vivo platelet activation responsible for enhanced vascular endothelial growth factor levels in hypertensive patients?
### Response:
| In vivo activation of platelets in hypertensive patients is responsible for enhanced circulating VEGF levels, which are significantly lowered by aspirin treatment. |
### Instruction:
Do type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia?
### Response:
| The overall quality of life in adult women with CAH is affected both by the type of mutation and operative procedure. Indications for clitoroplasty should be restrictive. Medical, surgical, and psychological treatment should be centralized. |
### Instruction:
Does an angiotensin II receptor antagonist reduce inflammatory parameters in two models of colitis?
### Response:
| These data demonstrate a possible anti-inflammatory effect for valsartan in colitis. |
### Instruction:
Do vanilloid receptor 1-positive neurons mediate thermal hyperalgesia and tactile allodynia?
### Response:
| VR1-positive neurons are essential for the development of mechanical allodynia. In rats already exhibiting neuropathic pain, the VR1-positive neurons mediate the most sensitive part of mechanical allodynia. RTX injection in sensory ganglia may represent a novel treatment for neuropathic pain. |
### Instruction:
Does comparison of results with different left ventricular pacing lead?
### Response:
| No significant differences in complication rates between systems and leads were observed. |
### Instruction:
Is functional gastrointestinal disorder associated with increased non-gastrointestinal healthcare consumption in the general population?
### Response:
| Functional gastrointestinal disorders are related to an increased demand on primary healthcare because of an increased overall comorbidity, which signifies a need for a holistic healthcare approach. |
### Instruction:
Is scavenger receptor class B type I a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81?
### Response:
| Our data suggest that SR-BI (i) represents a key host factor for HCV entry, (ii) is implicated in the same HCV entry pathway as CD81, and (iii) targets an entry step closely linked to HCV-CD81 interaction. |
### Instruction:
Does insulin treatment enhance the myocardial angiogenic response in diabetes?
### Response:
| Insulin treatment successfully reversed diabetic coronary endothelial dysfunction and significantly improved the endogenous angiogenic response. These pro-angiogenic effects may be mediated through downregulation of anti-angiogenic mediators. Insulin therapy appears to be a promising modality to enhance the angiogenic ... |
### Instruction:
Do effect of surgical techniques on primary implant stability and peri-implant bone?
### Response:
| Managing implant sites with the condensing-osteotome technique results in notable changes in peri-implant bone architecture but might not be as promising in improving primary implant stability compared with the drilling-osteotome technique. |
### Instruction:
Does [ L-arginine reduce intestinal epithelial cell apoptosis in rats with severe abdominal infection ]?
### Response:
| Severe abdominal infection results in increased apoptosis of the intestinal epithelial cells in rats, and L-Arg treatment may reduce the cell apoptosis. |
### Instruction:
Does terlipressin improve renal function in patients with cirrhosis and ascites without hepatorenal syndrome?
### Response:
| The vasopressin 1 receptor agonist terlipressin improves renal function and induces natriuresis in patients with cirrhosis and ascites without HRS. Vasoconstrictors may represent a novel future treatment modality for these patients. |
### Instruction:
Do effect of dental implant cross-sectional design on cortical bone structure using finite element analysis?
### Response:
| It was concluded that the unthreaded implant design produced the least bone stress. An increase in implant diameter could produce marked reduction in stress value in the bone around the neck of the implant. |
### Instruction:
Does peroxiredoxin I protect gastric mucosa from oxidative injury induced by H. pylori infection?
### Response:
| These data suggest that H. pylori infection upregulates gastric mucosal Prx I expression, and further, that Prx I plays an important role in gastric mucosal protection against oxidative injury induced by H. pylori infection. |
### Instruction:
Are malnutrition and hypermetabolism risk factors for the presence of hepatic encephalopathy : a cross-sectional study?
### Response:
| Our data do not support the hypothesis that malnutrition or tissue catabolism are independent risk factors for the presence of hepatic encephalopathy in patients with nonalcoholic cirrhosis. |
### Instruction:
Does [ AP-1 regulate TGF-beta1-induced secretion of Type I collagen in human lung fibroblasts ]?
### Response:
| AP-1 is responsible for the secretion of TGF-beta1-induced Type I collagen in human lung fibroblasts. |
### Instruction:
Does mast cell tryptase cause homologous desensitization of beta-adrenoceptors by Ca2+ sensitization in tracheal smooth muscle?
### Response:
| In mast cell myositis, tryptase released from mast cells acts on airway smooth muscle, leading to homologous beta-adrenergic desensitization mediated by [Ca(2+)](i)-independent mechanisms via PAR2 activation. |
### Instruction:
Does persistent hepatitis B viral replication affect recurrence of hepatocellular carcinoma after curative resection?
### Response:
| Persistent viraemia increased recurrence independently after surgery. To prevent long-term recurrences, antiviral therapy should be initiated in those with detectable serum HBV DNA. |
### Instruction:
Does crocin from Crocus sativus possess significant anti-proliferation effects on human colorectal cancer cells?
### Response:
| Data from this study demonstrated that Crocus sativus extract and its major constituent, crocin, significantly inhibited the growth of colorectal cancer cells while not affecting normal cells. Crocus sativus extract should be investigated further as a viable option in the treatment of colorectal cancer. |
### Instruction:
Does dihydropyrimidine dehydrogenase activity correlate with fluorouracil sensitivity in breast cancer?
### Response:
| Our study indicated that DPD is a promising molecular maker for identifying tumor cells sensitivity in breast cancer patients receiving FU-based chemotherapy. |
### Instruction:
Do paclitaxel-octreotide conjugates inhibit growth of human non-small cell lung cancer cells in vitro?
### Response:
| The paclitaxel-octreotide conjugates can be used as selective-targeted chemotherapeutic agents for treating non-small cell lung cancer. |
### Instruction:
Does dexamethasone-induced apoptosis in acute lymphoblastic leukemia involve differential regulation of Bcl-2 family members?
### Response:
| The differential regulation of pro- and anti-apoptotic Bcl-2 family members appears to be a key event in the execution of Dex-induced apoptosis in ALL cell lines, and also indicates a role for these proteins in primary ALL cells. |
### Instruction:
Is high-molecular weight adiponectin independently associated with the extent of coronary artery disease in men?
### Response:
| HMW adiponectin and the HMW/total-adiponectin ratio inversely correlate with the extent of CAD. HMW adiponectin in particular seems to be a better marker for CAD extent than total adiponectin. |
### Instruction:
Does [ Pentoxifylline promote learning and memory function of aging rats and mice with induced memory impairment ]?
### Response:
| Pentoxifylline can improve the learning and memory abilities of rats and mice. |
### Instruction:
Is protein expression of osteopontin in tumor tissues an independent prognostic indicator in gastric cancer?
### Response:
| Osteopontin protein expression was confirmed as a new independent predictor of tumor recurrence and poor prognosis in patients with gastric cancer. |
### Instruction:
Are dissociative symptoms positively related to stress in borderline personality disorder?
### Response:
| Our data suggest that BPD-patients might be prone to dissociation when experiencing stress and are characterized by a generally heightened level of dissociation. |
### Instruction:
Does inhibition of protein kinase Cbeta by enzastaurin enhance radiation cytotoxicity in pancreatic cancer?
### Response:
| Enzastaurin inhibits PKCbeta in pancreatic cancer cells in culture, enhancing radiation cytotoxicity. Additional antivascular effects of enzastaurin were observed in vivo, resulting in greater radiosensitization. These results provide the rationale for a clinical trial in locally advanced pancreatic cancer combining en... |
### Instruction:
Does tumor necrosis factor receptor-2 signaling attenuate vein graft neointima formation by promoting endothelial recovery?
### Response:
| TNF signaling via p75 reduces vein graft neointimal hyperplasia through mechanisms involving reduction of adhesion molecule expression and endothelial cell apoptosis. |
### Instruction:
Does plasma arachidonic acid influence insulin-stimulated glucose uptake in healthy adult women?
### Response:
| Support for the hypothesis that specific fatty acids influence IR is provided. Plasma arachidonic acid was associated to IR, independent on clinical/metabolic study variables. Docosahexaenoic and saturated fatty acids could potentially affect insulin action through modulating mitochondrial oxidative function. |
### Instruction:
Do immunological and microbiological investigations of patients with burn injuries?
### Response:
| The analyzed data may be of help in evaluating the risk of colonization and infection of the burn wound in patients with burn injuries. We would like to recommend a compulsory battery of microbiological tests and several immunological investigations phagocytic index, phagocytic number, leukocyte number, differential bl... |
### Instruction:
Does activation of phospholipase C gamma 1 protect renal arteriolar VSMCs from H2O2-induced cell death?
### Response:
| H2O2 increased PLCgamma1 expression and almost doubled total PLC activity, changes abolished by catalase. We conclude that H2O2 is cytotoxic to cultured VSMCs of renal preglomerular arterioles, a process that is attenuated by compensatory increases in PLCgamma1 protein level, tyrosine phosphorylation of PLCgamma1 and P... |
### Instruction:
Do growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice?
### Response:
| These data identify a temporal association between growth factor production and Th2 cytokine production and the kinetics of AHR. Growth factors may play important roles in the development of allergic airway inflammation and AHR even in the early stages of asthma, before remodeling is initiated. |
### Instruction:
Does surgical debulking of pituitary macroadenomas causing acromegaly improve control by lanreotide?
### Response:
| In this first prospective study using lanreotide, surgical debulking of pituitary tumours causing acromegaly improved subsequent postoperative control by the somatostatin analogue lanreotide. Surgery should, therefore, be considered in patients with macroadenoma causing acromegaly, even if there is little prospect of s... |
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