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### Instruction:
Does ex vivo spinal cord slice model of neuromyelitis optica reveal novel immunopathogenic mechanisms?
### Response:
| These results provide evidence for AQP4, complement- and NMO-IgG-dependent NMO pathogenesis in spinal cord, and implicate the involvement of specific immune cells and cytokines. Our ex vivo model allows for direct manipulation of putative effectors of NMO disease pathogenesis in a disease-relevant tissue. |
### Instruction:
Does analysis of 4999 online physician ratings indicate that most patients give physicians a favorable rating?
### Response:
| Most patients give physicians a favorable rating on online physician-rating sites. A single overall rating to evaluate physicians may be sufficient to assess a patient's opinion of the physician. The optimal content and rating method that is useful to patients when visiting online physician-rating sites deserves furthe... |
### Instruction:
Is nuclear survivin expression a positive prognostic factor in taxane-platinum-treated ovarian cancer patients?
### Response:
| It appears that TP53 status determines the clinical importance of nuclear survivin expression in taxane-platinum treated ovarian cancer patients. |
### Instruction:
Does anodization increase early integration of Osstem implants in sheep femurs?
### Response:
| The novel anodic oxidation technique increased early ossointegration of rough-surfaced implants by 157%. Neither clinical testing with resonant frequency analysis nor radiographic analysis using micro-CT had sufficient resolution to detect this improvement. Whether this gain in early bone-implant contact is clinically ... |
### Instruction:
Does degree of freezing affect efficacy of frozen gloves for prevention of docetaxel-induced nail toxicity in breast cancer patients?
### Response:
| A convenient preparation of FG at -10 to -20°C is almost as effective as a standard preparation at -25 to -30°C, with significantly less discomfort. |
### Instruction:
Are nuclear receptor HNF4α binding sequences widespread in Alu repeats?
### Response:
| Our findings suggest that HNF4α, in addition to regulating gene expression via high affinity binding sites, may also modulate transcription via low affinity sites in Alu repeats. |
### Instruction:
Are urinary complications in rectal cancer patients related to the dissection tool?
### Response:
| When compared to EC, TME with US is related to lower risk of urinary complications and facilitates autonomic nerve preservation due to minimized thermal lateral tissue damage. |
### Instruction:
Do small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in Pakistan?
### Response:
| SIBO was seen in a significant number of our patients with IBS-D. There was no significant age or gender difference in patients with or without SIBO. |
### Instruction:
Does mechanical testing of orthopedic suture material used for extra-articular stabilization of canine cruciate ligament-deficient stifle?
### Response:
| Polyblend suture materials are stronger and elongate less than MNL in pure tension. The mechanical performance of all sutures tested is questionable when compared with the mechanical demands of the normal stifle in a mid-sized dog. |
### Instruction:
Does androgen signaling in decidualizing human endometrial stromal cells enhance resistance to oxidative stress?
### Response:
| Androgens might play a critical role in the decidualization process at the time of embryo implantation and trophoblast invasion by promoting resistance to oxidative stress. |
### Instruction:
Are latent myofascial trigger points associated with an increased antagonistic muscle activity during agonist muscle contraction?
### Response:
| This study shows that MTPs are associated with reduced efficiency of reciprocal linhibition, which may contribute to the delayed and incomplete muscle relaxation following exercise, disordered fine movement control, and unbalanced muscle activation. Elimination of latent MTPs and/or prevention of latent MTPs from becom... |
### Instruction:
Does bAG3 down-modulation reduce anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein?
### Response:
| BAG3 protein sustains ATC growth in vitro and in vivo. The underlying molecular mechanism appears to rely on BAG3 binding to BRAF, thus protecting it from proteasome-dependent degradation. These results are in line with the reported ability of BAG3 to interfere with the proteasomal delivery of a number of other client ... |
### Instruction:
Does amyloid peptide regulate calcium homoeostasis and arrhythmogenesis in pulmonary vein cardiomyocytes?
### Response:
| Aβ(25-35) has direct electrophysiological effects on PV cardiomyocytes. |
### Instruction:
Are rhinitis symptoms caused by grass pollen associated with elevated basophile allergen sensitivity and a larger grass-specific immunoglobulin E fraction?
### Response:
| Allergic rhinitis symptoms are significantly associated with allergen-specific basophile sensitivity. In vitro evaluation of basophile sensitivity should prove useful for distinguishing clinical phenotype of allergic sensitization. |
### Instruction:
Does staphylococcal enterotoxin B compromise the immune tolerant status in the airway mucosa?
### Response:
| The components of immune tolerance machinery, TolDCs and Tregs were suppressed in the AR nasal mucosa. The increases in SEB and decreases in avb6 in nasal epithelium are associated with the compromises of immune tolerance in the nasal mucosa. SEB has the ability to suppress the expression of avb6 in nasal epithelial ce... |
### Instruction:
Does nicotinamide mononucleotide adenylyltransferase 1 gene NMNAT1 regulate neuronal dendrite and axon morphogenesis in vitro?
### Response:
| These findings reveal a novel role for NMNAT1 in the morphogenesis of developing cortical neurons, which indicate that the loss of function of NMNAT1 may contribute to different neurodegenerative disorders in central nervous system. |
### Instruction:
Are m2-polarized tumor-associated macrophages associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma?
### Response:
| Tumor-associated macrophages in lung adenocarcinoma have an M2-polarized subtype and are associated with poor prognoses, perhaps resulting from accelerated lymphangiogenesis and lymph node metastasis. |
### Instruction:
Does calcitonin gene-related peptide suppress isoprenaline-induced cardiomyocyte apoptosis through regulation of microRNA-1 and microRNA-133a expression?
### Response:
| CGRP can inhibit the isoprenaline-induced cardiomyocyte apoptosis. The beneficial effect of CGRP is related to regulating microRNA-1 and microRNA-133a expression through the prevention of isoprenaline-induced ROS production. |
### Instruction:
Do bone screws have advantages in repair of experimental osteochondral fragments?
### Response:
| Our results show better repaired tissue was observed for quality and quantity when chondral fractures were treated with bone screws than when treated with PLLA screws. |
### Instruction:
Does bio-Oss® blocks combine with BMP-2 and VEGF for the regeneration of bony defects and vertical augmentation?
### Response:
| In the chosen setting and time frame, de novo bone formation did not increase with the additional use of growth factors. |
### Instruction:
Does aluminum alter NMDA receptor 1A and 2A/B expression on neonatal hippocampal neurons in rats?
### Response:
| Treated hippocampal neurons with 37 and 74 μM of Al for 14 days increased neural cell viability, but hampered NMDAR 1A and NMDAR 2A/B expressions. It was suggested that Al exposure might alter the development of hippocampal neurons in neonatal rats. |
### Instruction:
Do angiogenic biomarkers predict the occurrence of digital ulcers in systemic sclerosis?
### Response:
| This study identified high PlGF serum levels and low circulating EPC counts as predictors of new digital ulcers in SSc. It highlights the critical role of angiogenesis in this vascular outcome. These markers may improve digital ulcer risk stratification and therefore allow earlier therapeutic intervention. |
### Instruction:
Does lung function distinguish preschool children with CF from healthy controls in a multi-center setting?
### Response:
| Spirometry appears more sensitive than IP or FO for detecting lung disease in CF preschoolers; spirometric indices decline with age. Future trials using spirometry should include a run-in period for training and require acceptable data prior to enrollment. However, near-normal spirometric measurements in CF preschooler... |
### Instruction:
Is factor VII R353Q genetic polymorphism associated with altered warfarin sensitivity among CYP2C9 *1/*1 carriers?
### Response:
| The response to warfarin during induction is influenced by factor VII R353Q polymorphism. The prospective use of this polymorphism, along with CYP2C9 and VKORC1, may enhance the accuracy of warfarin loading. However, the impact of R353Q polymorphism on overall warfarin response is subtle, and it is therefore unlikely t... |
### Instruction:
Does ultra-wide-field angiography improve the detection and classification of diabetic retinopathy?
### Response:
| Compared with conventional 7SF imaging, ultra-wide-field fluorescein angiography reveals significantly more retinal vascular pathology in patients with diabetic retinopathy. Improved retinal visualization may alter the classification of diabetic retinopathy and may therefore influence follow-up and treatment of these p... |
### Instruction:
Do quality of care provided in a special needs plan using a nurse care manager model?
### Response:
| Comprehensive quality measurement applied to vulnerable older adults enrolled in one mature SNP showed that the Evercare nurse model addresses important deficits in physician care for geriatric conditions. Such measurement should be applied to other SNP models and to compare SNP care with that for complex, older, fee-f... |
### Instruction:
Is assessment of BCR-ABL1 transcript levels at 3 months the only requirement for predicting outcome for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors?
### Response:
| A single measurement of BCR-ABL1 transcripts performed at 3 months is the best way to identify patients destined to fare poorly, thereby allowing early clinical intervention. |
### Instruction:
Are risk of venous thromboembolism after spinal cord injury : not all levels the same?
### Response:
| The rate of VTE differs with various SCI levels. Patients with high thoracic (T1-6) injury seem to be at the highest risk and patients with high cervical (C1-4) injury at one of the lowest. A higher index of suspicion for VTE should therefore be maintained in patients with a high thoracic SCI. Further studies are requi... |
### Instruction:
Do cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines?
### Response:
| Our results clearly suggest that enhanced anti-FliC antibody-mediated clearance of S. Paratyphi A by phagocytic cells, induced by vaccines expressing cell-associated rather than exported FliC, might be contributing to the vaccine-induced protection from S. Paratyphi A challenge in vivo. We speculate that an excess of I... |
### Instruction:
Does thrombosis in suspected heparin-induced thrombocytopenia occur more often with high antibody levels?
### Response:
| Higher levels of anti-PF4/heparin antibody are associated with increased thrombosis risk among patients with clinically suspected heparin-induced thrombocytopenia and might have clinical utility for prediction of true heparin-induced thrombocytopenia and the development of thrombosis. |
### Instruction:
Is androgen deprivation therapy before radical prostatectomy associated with poorer postoperative erectile function outcomes?
### Response:
| Our data suggest that preoperative use of ADT adversely impacts EF outcomes and should therefore be avoided in the absence of robust data suggesting any oncological benefit. |
### Instruction:
Do amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex?
### Response:
| Our results indicate that BLA-PFC pathways inhibited PFC nociceptive cell activities and that the DA system modifies the BLA-PFC regulatory function. |
### Instruction:
Do pilose antler polypeptides promote chondrocyte proliferation via the tyrosine kinase signaling pathway?
### Response:
| The data demonstrate that PAP promotes chondrocyte proliferation with the increased cell number, percentage proportion of chondrocytes in S phase and expression of protein cyclin A via the TK signaling pathway. |
### Instruction:
Does incidental pancreatography via ERCP in patients with anomalous pancreaticobiliary junction result in pancreatitis in a North American population?
### Response:
| In North American patients undergoing ERCP, 1.1% of patients had APBJ. Our study population was predominately Caucasian, male, and in all but one patient lacked a history of prior pancreatitis. No patient developed post-ERCP pancreatitis. This suggests that APBJ may have different clinical manifestations in a North Ame... |
### Instruction:
Is tGF-beta 1 a potential regulator of vaginal tropoelastin production?
### Response:
| There is a positive correlation between TGF-β1 and elastin mRNA expression in the vaginal wall. In vitro, TGF-β1 increases vaginal tropoelastin production in vaginal SMC. |
### Instruction:
Are the cardioprotective effects of parathyroid hormone independent of endogenous granulocyte-colony stimulating factor release?
### Response:
| The cardioprotective effects of PTH were shown to be independent of endogenous G-CSF release and therefore from stem cell mobilization. This puts more emphasis on the role of stem cell homing into ischaemic myocardium. |
### Instruction:
Do effect of vertical misfit on strain within screw-retained implant titanium and zirconia frameworks?
### Response:
| Framework misfit clearly influenced the framework strain magnitude and pattern. The framework material did not affect the framework strain for a similar level of misfit. |
### Instruction:
Is high expression of CCL20 associated with poor prognosis in patients with hepatocellular carcinoma after curative resection?
### Response:
| CCL20 expression was associated with tumor recurrence and survival of HCC patients. It may be used to predict prognosis of patients with HCC and may be a new target of postoperative adjuvant therapy. |
### Instruction:
Is symptomatic low-grade carotid stenosis with intraplaque hemorrhage and expansive arterial remodeling associated with a high relapse rate refractory to medical treatment?
### Response:
| Symptomatic low-grade carotid stenosis with vulnerable plaque confirmed by MRI was associated with a high rate of stroke recurrence that was refractory to aggressive medical treatment. However, carotid endarterectomy was safe and effective for such patients. Plaque characterization by MRI has the potential for more acc... |
### Instruction:
Does serum-cobalt levels with metal-on-metal bearings in the cement-free total hip arthroplasty result covering two years ; prospective study?
### Response:
| It was the goal of our prospective study to compare clinical and radiological results of hip arthroplasty in metal-on-metal and ceramic-on-ceramic bearings and assess the serum-cobalt and the serum-aluminium levels. The socalled "biocorrosion" is still a high risk element for loosening of implants because of aseptic os... |
### Instruction:
Are psychosocial outcomes related to asthma control and quality of life in pregnant women with asthma?
### Response:
| In pregnancy, women with asthma experience good QoL but overestimate teratogenic risks of asthma medication. Maintenance ICS use, illness beliefs, and anxiety are associated with impaired QoL and asthma control. |
### Instruction:
Does ischemic preconditioning protect against myocardial ischemia-reperfusion injury through inhibiting toll-like receptor 4/NF-κB signaling pathway in rats?
### Response:
| IPC protects against myocardial I/R injury by inhibition of TLR4/NF-κB pathway. These effects are related to the increased the release of CGRP. |
### Instruction:
Are 25-Hydroxyvitamin-D3 levels positively related to subsequent cortical bone development in childhood : findings from a large prospective cohort study?
### Response:
| In contrast to 25(OH)D(2), 25(OH)D(3) was positively related to subsequent cortical bone mass and predicted strength. In vitamin D-deficient children in whom supplementation is being considered, our results suggest that D(3) should be used in preference to D(2). |
### Instruction:
Is naringenin an inhibitor of human serum paraoxonase ( PON1 ) : an in vitro study?
### Response:
| Lipophilic property appears to be an important feature of the structure in evaluating the inhibitor potential. Comparison of our findings and other authors showed that the induction of PON1 gene by naringenin and its inhibitory effects on the enzyme protein are probably two different mechanisms by which the flavonoid a... |
### Instruction:
Does beta-xylosidase activity of a GH3 glucosidase/xylosidase from yak rumen metagenome promote the enzymatic degradation of hemicellulosic xylans?
### Response:
| The RuBGX1 shows β-glucosidase activity in hydrolysis of cello-oligosaccharides; meanwhile, it has β-xylosidase activity and functions synergistically with endoxylanase to promote the degradation of hemicellulosic xylans. |
### Instruction:
Does quantification of optic disc edema during exposure to high altitude show no correlation to acute mountain sickness?
### Response:
| Exposure to high altitude leads to reversible ODE in the majority of healthy subjects. However, these changes did not correlate with AMS or basic physiologic parameters such as SpO₂ and HR. For the first time, a quantitative approach has been used to assess these changes during acute, non-acclimatized high altitude exp... |
### Instruction:
Is articular inflammation controlled by myeloid cell-derived interleukin 1 receptor antagonist during the acute phase of arthritis in mice?
### Response:
| Myeloid cell-derived IL-1Ra, including both sIL-1Ra and icIL-1Ra3 isoforms, controls articular inflammation during the acute phase of K/BxN serum transfer-induced arthritis. |
### Instruction:
Does skin surface hydration decrease rapidly during long distance flights?
### Response:
| Our results demonstrate that during long distance flights, the aircraft cabin environment leads to a rapid decrease in stratum corneum hydration, an alteration, which probably accounts for the discomfort experienced by long distance aircraft travellers. |
### Instruction:
Are low serum testosterone levels predictive of prostate cancer?
### Response:
| This study supports experimental findings that testosterone levels are predictor of prostate cancer and that prostate cancer is frequently associated with low testosterone levels. In the diagnostic work-up for prostate cancer, adding testosterone determination to PSA test may improve predictive accuracy. |
### Instruction:
Does oral malodorous compound cause caspase-8 and -9 mediated programmed cell death in osteoblasts?
### Response:
| At less-than-pathological concentrations in gingival crevicular fluid, H(2) S induces apoptosis in osteoblasts. The molecular mechanisms underlying the apoptotic process include p53, a mitochondrial pathway and caspase-8 activation. |
### Instruction:
Does carbidopa enhance antitumoral activity of bicalutamide on the androgen receptor-axis in castration-resistant prostate tumors?
### Response:
| This study demonstrates preclinical proof-of-principle that pharmacological targeting of prostate tumors by combination treatment of bicalutamide plus carbidopa significantly reduces AR activity, and thereby delays CRPC tumor progression in vivo. |
### Instruction:
Are implantable cardioverter-defibrillator patients who upgraded and respond to cardiac resynchronization therapy have less ventricular arrhythmias compared with nonresponders?
### Response:
| After upgrade from ICD to CRT-D, nonresponders to CRT showed a significant increase in VA burden requiring appropriate device therapy. |
### Instruction:
Are serum CXCL1 concentrations elevated in type 1 diabetes mellitus , possibly reflecting activity of anti-islet autoimmune activity?
### Response:
| To our knowledge, this is the first study to show elevated serum CXCL1 in T1DM subjects, regardless of diabetes subtype, as compared to control type 2 diabetes mellitus subjects. We propose serum CXCL1 elevation to be a good T1DM marker, possibly indicating a predisposition to autoimmune disease development. |
### Instruction:
Does the combination of metallothionein and superoxide dismutase protect pancreatic β cells from oxidative damage?
### Response:
| Transduction of Tat-MT and Tat-SOD proteins offers a new strategy for protecting against the development of diabetes by relieving oxidative stress. |
### Instruction:
Does interleukin-6 treatment induce beta-cell apoptosis via STAT-3-mediated nitric oxide production?
### Response:
| Our results show that exposure to interleukin-6 for 48 h can induce beta-cell death, in part via signal transducers and activators of transcription-3-mediated NO production. |
### Instruction:
Is overexpression of survivin correlated with increased invasion and metastasis of colorectal cancer?
### Response:
| Targeting survivin will be a potential strategy to suppress metastasis of CRC. |
### Instruction:
Do soil amendments with Brassica cover crops for management of Phytophthora blight on squash?
### Response:
| The results indicated that some Brassica crops, particularly mustard and canola, had the potential to significantly reduce Phytophthora blight on squash when used as soil amendments. As P. capsici has a remarkable ability to develop resistance to chemical fungicides, use of effective Brassica cover crops could be a bio... |
### Instruction:
Does functional coupling analysis suggest link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway?
### Response:
| Gene expression studies validate several candidates generated through database studies of possible FTO-interactors. We speculate about a wider functional role for FTO in the context of current and recent findings, such as in extracellular ligand-induced neuronal plasticity via NTRK2/BDNF, possibly via interaction with ... |
### Instruction:
Do [ Severe vascular complications of Le Fort I osteotomy ]?
### Response:
| Vascular complications of Le Fort I osteotomies are rare (0.55% in our series). They are most frequently hemorrhagic complications. |
### Instruction:
Are high levels of hsCRP associated with carbohydrate metabolism disorder?
### Response:
| We sustain that high levels of hsCRP are associated with disturbance in carbohydrate metabolism. In addition, we believe that in low cardiovascular risk population, such as NG women, uric acid levels above 3.9 mg/dl might represent a signal of possible pro-inflammatory state and cardiovascular risk. |
### Instruction:
Are endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines involved in sensitivity to rituximab-induced apoptosis?
### Response:
| Collectively, these data strongly suggest that a neurotrophin axis, such NGF/TrkA pathway, may contribute to malignant cell survival and rituximab resistance in DLBCL. |
### Instruction:
Does co-morbid diabetes in patients with Crohn 's disease predict a greater need for surgical intervention?
### Response:
| Co-morbid diabetes in patients with Crohn's disease predicts a greater need for surgical intervention. |
### Instruction:
Does intravenous injection of autologous amniotic fluid induce transient thrombocytopenia in a gravid rabbit model of amniotic fluid embolism?
### Response:
| The syndrome of AFE was not reproduced in this rabbit model. However, injection of autologous amniotic fluid induced a transient and severe thrombocytopenia. Moreover, TEG analysis indicated that amniotic fluid could initiate the coagulation cascade. Other factors such as the presence of meconium in amniotic fluid may ... |
### Instruction:
Does inspiratory loading intensity influence lactate clearance during recovery?
### Response:
| These data suggest that, in individuals of moderate endurance training status, inspiratory loading at the intensities used in the present study does not accelerate lactate clearance or modify plasma acid-base balance during recovery from maximal exercise. |
### Instruction:
Does cD4-mediated regulatory T-cell activation inhibit the development of disease in a humanized mouse model of allergic airway disease?
### Response:
| Allergic airway inflammation can be prevented by stimulation of human Treg cells by CD4. These results suggest a clinical potential of Treg-cell activation by high-affinity CD4 ligands in allergic diseases. |
### Instruction:
Do ethnic differences in burn mechanism and severity in a UK paediatric population?
### Response:
| These results show that there are significant differences in the patterns of burns in ethnic minority groups. This data should guide targeted public health prevention and educational strategies. |
### Instruction:
Does bile acid sequestration reduce plasma glucose levels in db/db mice by increasing its metabolic clearance rate?
### Response:
| BAS induced plasma glucose lowering in db/db mice by increasing metabolic clearance rate of glucose in peripheral tissues, which coincided with decreased skeletal muscle long-chain acylcarnitine content. |
### Instruction:
Do eGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells?
### Response:
| We demonstrated for the first time the molecular mechanism of C225-NP induced cytotoxic effects in lung cancer cells that are not characteristic for free molecular therapeutics thus increasing efficacy of therapy against NSCLC. |
### Instruction:
Does non-surgical periodontal therapy improve oral health-related quality of life?
### Response:
| This study demonstrates that OHQoL, in particular, pain and psychological subdomains, improvement was associated with non-surgical periodontal therapy responses. Clinicians could capitalize upon the positive psychological OHQoL impacts of mechanical periodontal treatment for subsequent patient-centred motivation during... |
### Instruction:
Does p53 dependent centrosome clustering prevent multipolar mitosis in tetraploid cells?
### Response:
| p53 could not prevent tetraploid cells entering mitosis or induce tetraploid cell death. However, p53 abnormality impaired centrosome clustering and lead to multipolar mitosis in tetraploid cells by modulating the RhoA/ROCK signaling pathway. |
### Instruction:
Are obesity and aspirin intolerance risk factors for difficult-to-treat asthma in Japanese non-atopic women?
### Response:
| Significant associations of obesity and aspirin intolerance with DTA were observed only in women and in non-atopics. These findings suggest that a phenotype-specific approach is needed to treat patients with DTA. |
### Instruction:
Does khat ( Catha edulis ) alter the phenotype and anti-microbial activity of peripheral blood mononuclear cells?
### Response:
| These data suggest that khat may severely influence the effectiveness of immune surveillance and anti-microbial capacity of PBMCs. |
### Instruction:
Does β-catenin repress expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells?
### Response:
| These data suggest a novel role for β-catenin in promoting colorectal tumorigenesis through very early 15-PGDH suppression leading to increased PGE(2) levels, possibly even before COX-2 upregulation. |
### Instruction:
Does ingestion of 10 grams of whey protein prior to a single bout of resistance exercise augment Akt/mTOR pathway signaling compared to carbohydrate?
### Response:
| Ingestion of 10 g of whey protein prior to an acute bout of lower body resistance exercise had no significant preferential effect compared to carbohydrate on systemic and cellular signaling markers indicative of muscle protein synthesis in untrained individuals. |
### Instruction:
Are uterine and ovarian carcinosarcomas overexpressing Trop-2 sensitive to hRS7 , a humanized anti-Trop-2 antibody?
### Response:
| Trop-2 is overexpressed in a proportion of UMMT and OMMT, and hRS7 may represent a novel, potentially highly effective treatment option for patients with treatment-refractory carcinosarcomas overexpressing Trop-2. |
### Instruction:
Is delta-like 4/Notch pathway differentially regulated in benign and malignant thyroid tissues?
### Response:
| The detection of Notch1, Notch4, and DLL4 in thyrocytes and their regulation in various pathologies suggest that this pathway may play a role in thyroid carcinogenesis and angiogenesis. |
### Instruction:
Does insulin augment tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells?
### Response:
| hyperinsulinemia and insulin resistance appear to augment the inflammatory effects of TNFα on VCAM-1 expression and NFκB translocation, both of which are markers of inflammation in the vasculature. |
### Instruction:
Does benzonidazole therapy modulate interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children?
### Response:
| Anti-M2R AAbs and IFN-γ raise early during chagasic infection in children and are downmodulated by BZ therapy. These findings reinforce the usefulness of early BZ treatment not only to eliminate the parasite but also to reduce potentially pathogenic immune responses. |
### Instruction:
Is albumin-binding capacity ( ABiC ) reduced in patients with chronic kidney disease along with an accumulation of protein-bound uraemic toxins?
### Response:
| Impaired albumin function in CKD patients can be quantified, is related to severity of kidney disease and is associated with an accumulation of uraemic albumin-bound retention solutes. |
### Instruction:
Does short-term serum deprivation confer sensitivity to taxanes in platinum-resistant human ovarian cancer cells?
### Response:
| These results indicate that serum deprivation confers taxane hypersensitivity specifically in platinum-resistant cells by recovering their impaired mitochondrial functions. The evidence might be clinically beneficial for the development of new chemotherapeutic technology, particularly for the patients with platinum-res... |
### Instruction:
Does constitutive expression of a grapevine polygalacturonase-inhibiting protein affect gene expression and cell wall properties in uninfected tobacco?
### Response:
| This evaluation of PGIP over-expressing plants performed under pathogen-free conditions to exclude the classical PGIP-ePG inhibition interaction indicates additional roles for PGIPs beyond the inhibition of ePGs. |
### Instruction:
Is video game playing independently associated with blood pressure and lipids in overweight and obese adolescents?
### Response:
| Playing video games was the only form of sedentary behaviour that was independently associated with increased BP and lipids. Our findings provide support for reducing time spent playing seated video games as a possible means to promote health and prevent the incidence of cardiovascular disease (CVD) risk factors in thi... |
### Instruction:
Are mast cells required in the proliferation and remodeling phases of microdeformational wound therapy?
### Response:
| Mast cells are critical in the robust granulation tissue response seen in microdeformational wound therapy and in the modulation of the remodeling phase of wound healing. |
### Instruction:
Does human milk adiponectin affect infant weight trajectory during the second year of life?
### Response:
| High human milk APN exposure was associated with accelerated weight trajectory during the second year of life, suggesting its role in catch-up growth after slower weight gain during the first year of life. |
### Instruction:
Do tP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence?
### Response:
| Disruptive TP53 mutations in HNSCC tumors predicts for LRR, because of increased radioresistance via the inhibition of senescence. Metformin can serve as a radiosensitizer for HNSCC with disruptive TP53, presaging the possibility of personalizing HNSCC treatment. |
### Instruction:
Does anti-EGFR antibody cetuximab enhance the cytolytic activity of natural killer cells toward osteosarcoma?
### Response:
| Our data show that the cytolytic potential of resting NK cells can be potentiated and directed toward osteosarcoma cells with cetuximab. Therefore, cetuximab-mediated immunotherapy may be considered a novel treatment modality in the management of advanced osteosarcoma. |
### Instruction:
Does spinal cord stimulation with hybrid lead relieve pain in low back and legs?
### Response:
| SCS with a hybrid lead in subjects with FBSS is safe, and causes significant pain relief in both the low back and the lower limbs. |
### Instruction:
Does vectorcardiography show cardiac memory and repolarization heterogeneity after ablation of accessory pathways not apparent on ECG?
### Response:
| According to VCG analysis cardiac memory was present after ablation of overt APs independent of location as consistently as after ventricular pacing, and disappeared within a similar time frame during normal ventricular activation. In addition, signs of transient repolarization heterogeneity were observed after ablatio... |
### Instruction:
Do delta screw versus RetroScrew tibial fixation for ACL reconstruction?
### Response:
| In an osteoporotic cadaveric model, there was no significant biomechanical advantage of the RetroScrew system versus the Delta screw for tibial fixation in soft tissue graft ACL reconstruction. However, a trend toward lower graft fixation failure to cyclic loading was noted with the RetroScrew system. |
### Instruction:
Does erythropoietin improve skeletal muscle microcirculation through the activation of eNOS in a mouse sepsis model?
### Response:
| Our results suggest that eNOS plays an important role in mediating the beneficial effect of rHuEPO on microcirculation in this septic mouse model. |
### Instruction:
Do effect of Poloxamer 188 on deepening of deep second-degree burn wounds in the early stage?
### Response:
| Systemic application of P188 on deep second-degree burn wounds at the early stage may alleviate wound deepening, whose mechanism may be related to timely sealing up the damaged cell membrane and inhibiting the inflammatory reaction. |
### Instruction:
Do soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury?
### Response:
| Soy isoflavones augment destruction of A549 lung tumor nodules by radiation, and also mitigate vascular damage, inflammation and fibrosis caused by radiation injury to normal lung tissue. Soy could be used as a non-toxic complementary approach to improve RT in NSCLC. |
### Instruction:
Does transient but not stable ZEB1 knockdown dramatically inhibit growth of malignant pleural mesothelioma cells?
### Response:
| RNA interference-mediated ZEB1 knockdown may be a promising therapeutic strategy for MPM, but one has to consider the possibility of diminished growth inhibitory effects of long-term ZEB1 knockdown, possibly as a result of EpCAM up-regulation and/or other gene expression changes resulting from ZEB1 knockdown. |
### Instruction:
Is day-care service use a risk factor for long-term care placement in community-dwelling dependent elderly?
### Response:
| The results highlight the need for effective measures to reduce the long-term care placement of day-care service users. Policy makers and practitioners must consider implementing multidimensional support programs to reduce the caregivers' willingness to consider long-term care placement. |
### Instruction:
Is mll5 required for normal spermatogenesis?
### Response:
| Our data demonstrate a clear role of Mll5 in mammalian spermatogenesis at the level of terminal differentiation providing further support for its classification in the SET3 branch of proteins. Moreover, this study identifies Tlk2, Utx, Gpr64, Sult4a1, Rap2ip, Vstm2 and HoxA10 as possible Mll5 targets that together may ... |
### Instruction:
Is overexpression of ADK in human astrocytic tumors and peritumoral tissue related to tumor-associated epilepsy?
### Response:
| These results suggest a dysregulation of ADK in astrocytic brain tumors. Moreover, the upregulation of ADK observed in peritumoral infiltrated tissue of glioma patients with epilepsy supports the role of this enzyme in tumor-associated epilepsy. |
### Instruction:
Is cystatin C associated with inflammation but not atherosclerosis in systemic lupus erythematosus?
### Response:
| Cystatin C was higher in patients with SLE than in control subjects even after adjustment for conventional measures of renal function. Cystatin C was significantly correlated with several markers of inflammation in SLE but was not associated with coronary atherosclerosis. Subtle renal dysfunction does not appear to be ... |
### Instruction:
Does systemic administration of LPS worsen delayed deterioration associated with vasospasm after subarachnoid hemorrhage through a myeloid cell-dependent mechanism?
### Response:
| LPS administration before SAH worsens DDAV through a myeloid cell-dependent mechanism supporting studies in humans which show that systemic inflammation increases the likelihood of developing DDAV. |
### Instruction:
Does intramural delivery of bortezomib inhibit restenosis following arterial injury?
### Response:
| Intramural delivery of bortezomib reduces neointimal formation, possibly via a mechanism involving upregulation of the p27 and downregulation of the NF-kappaB. Bortezomib therefore may be an alternative therapeutic approach for preventing restenosis. |
### Instruction:
Does ambient temperature affect thrombotic potential at rest and following exercise?
### Response:
| Coagulation potential is elevated during exposure to cold temperatures. These data suggest that risk of an ischemic event may be elevated in the cold. |
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