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### Instruction:
Is reduction of butyrylcholinesterase activity in plasma from patients with disorders of propionate metabolism prevented by treatment with L-carnitine and protein restriction?
### Response:
| The results suggest that an increased free radicals formation may be involved in the decrease of butyrylcholinesterase activity, possibly contributing to the neurological damage of these disorders, and that treatment with L-carnitine and low-protein diet possibly is able to prevent this damage. |
### Instruction:
Is periodontitis associated with angiographically verified coronary artery disease?
### Response:
| Compared with patients with no significant stenosis, poor periodontal health including missing teeth, periodontal inflammation, and bone loss is associated with angiographically verified coronary artery narrowing in patients with stable CAD or ACS. |
### Instruction:
Is stage of hepatocellular carcinoma associated with periodontitis?
### Response:
| HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis. |
### Instruction:
Do receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis?
### Response:
| RANKL antagonists and Kavain effectively reduced alveolar bone loss in P. gingivalis-induced periodontitis in our mice model. Compared with RANK-Fc, Kavain-treated animals showed milder improvement of bone and connective tissue inflammation. Therapeutic implications in the prevention of periodontal bone loss are discus... |
### Instruction:
Does human HERC5 restrict an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag?
### Response:
| HERC5 represents a potential new host factor that blocks an early stage of retroviral Gag particle assembly. With no apparent HIV-1 protein that directly counteracts it, HERC5 may represent a new candidate for HIV/AIDS therapy. |
### Instruction:
Does [ Cisplatin enhance TRAIL-induced apoptosis in gastric cancer cells through clustering death receptor 4 into lipid rafts ]?
### Response:
| Cisplatin enhances TRAIL-induced apoptosis in gastric cancer MGC803 cells through clustering death receptors into lipid rafts. |
### Instruction:
Do early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice?
### Response:
| A fast and efficient Y. pestis dissemination in SEG mice may be critical for the triggering of an early and effective innate immune response necessary for surviving plague. |
### Instruction:
Do tNFα inhibitors restrict T cell activation and cycling via Notch-1 signalling in inflammatory bowel disease?
### Response:
| TNFα inhibitors potently inhibit T cell function. By demonstrating for the first time that Notch-1 mediates the inhibitory effects of adalimumab and infliximab on T cell cycling, this study reveals a new mode of action and also an underlying signalling pathway by which biological agents act in IBD. |
### Instruction:
Does interleukin-6-driven progranulin expression increase cholangiocarcinoma growth by an Akt-dependent mechanism?
### Response:
| Evidence is presented for a role for progranulin as a novel growth factor regulating cholangiocarcinoma growth. Specific targeting of progranulin may represent an alternative for the development of therapeutic strategies. |
### Instruction:
Do an update on facial transplantation cases performed between 2005 and 2010?
### Response:
| This report provides a useful overview of the technical aspects of face transplantation; however, the reports on long-term functional and aesthetic outcomes will help to define the future of face transplantation. |
### Instruction:
Do investigation of relationship between inhalation injury assessment and prognosis in burn patients?
### Response:
| Bronchoscopic findings, age, TBSA burned, P/F ratio were related with mortality in inhalation patients. When the international standardization of bronchoscopic classification developed, it can be possible to assess the inhalation patients more objectively and that will lead to the advancement in inhalation treatment an... |
### Instruction:
Do profound high-frequency sensorineural hearing loss treatment with a totally implantable hearing system?
### Response:
| The Esteem totally implantable middle ear hearing device provides appreciable functional gain and improvement in WRS to rehabilitate hearing in patients with a profound high-frequency sensorineural hearing loss. |
### Instruction:
Does integration of repulsive guidance cues generate avascular zones that shape mammalian blood vessels?
### Response:
| These findings demonstrate that Sema3E-generated avascular zones are critical regulators of mammalian cardiovascular patterning and are the first to identify a repulsive role for the lateral plate mesoderm. Integration of multiple, and in some cases redundant, repulsive cues from various tissues is critical to patterni... |
### Instruction:
Is the perlecan fragment LG3 a novel regulator of obliterative remodeling associated with allograft vascular rejection?
### Response:
| These results indicate that LG3 is a novel regulator of obliterative vascular remodeling during rejection. |
### Instruction:
Does the combination of high-fat diet-induced obesity and chronic ulcerative colitis reciprocally exacerbate adipose tissue and colon inflammation?
### Response:
| Our results demonstrated the relationship between ulcerative colitis and obesity as aggravating factors for each disease, with increased inflammation in the colon and adipose tissue and systemic alterations observed in the spleen, lymph nodes and bloodstream. |
### Instruction:
Is obesity associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy : results from the SEARCH database?
### Response:
| • Among men treated with early ADT, our results suggest that obese men may have increased risk of PC progression. • These data support the general hypothesis that obesity is associated with aggressive PC, although validation of these findings and further study of the mechanisms linking obesity and poor PC outcomes are ... |
### Instruction:
Does co-culture with microglia promote neural stem cells differentiation into astrocytes?
### Response:
| Microglias act as a regulator of NSCs astrogliogenesis. |
### Instruction:
Is neonatal cytokine profile in the airway mucosal lining fluid skewed by maternal atopy?
### Response:
| Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life. |
### Instruction:
Does guidewire biliary cannulation reduce post-ERCP pancreatitis compared with the contrast injection technique in low-risk and high-risk patients?
### Response:
| Lack of randomization. |
### Instruction:
Are polymorphisms within Fas gene associated with occult hepatitis B virus infection : Polymorphisms within Fas gene in occult HBV infection?
### Response:
| The functional polymorphisms in the promoter region of Fas gene are not associated with OBI. Therefore, it may be concluded that polymorphisms at the -670 position of the Fas gene do not have any critical effects on the immune response against HBV in OBI. |
### Instruction:
Does betaine excretion correlate with plasma homocysteine when plasma lipids are elevated?
### Response:
| This correlation is associated with patients with elevated plasma lipids. |
### Instruction:
Does prominin-1 localize to the open rims of outer segment lamellae in Xenopus laevis rod and cone photoreceptors?
### Response:
| These findings suggest that xlProminin-1 may serve as an anti-fusogenic factor in the regulation of disk morphogenesis and may help to maintain the open lamellar structure of basal ROS and COS disks in X. laevis photoreceptors. |
### Instruction:
Does ethanol increase GABAergic transmission and excitability in cerebellar molecular layer interneurons from GAD67-GFP knock-in mice?
### Response:
| Ethanol exposure differentially increases GABA release at stellate cell vs. basket cell-to-Purkinje cell synapses. This effect may contribute to the abnormalities in cerebellar function associated with alcohol intoxication. |
### Instruction:
Are multiple Trypanosoma infections common amongst Glossina species in the new farming areas of Rufiji district , Tanzania?
### Response:
| All tsetse species found in Rufiji are biologically important in the transmission of animal trypanosomiasis and the absence of T. congolense in G. m. morsitans could be a matter of chance only. Therefore, plans for control should consider all tsetse species. |
### Instruction:
Does the proximodistal aggravation of colitis depend on substance P released from TRPV1-expressing sensory neurons?
### Response:
| The spatial correlation among increased colonic innervation density, TRPV1 receptor expression, stimulated SP release, and colitis severity suggested that TRPV1/SP-expressing sensory neurons should be considered as a therapeutic target in human ulcerative colitis. |
### Instruction:
Does bronchoepithelial expression of CXCR1 and CXCR2 facilitate transepithelial migration of neutrophils?
### Response:
| The data of the present study do not support the hypothesis that bronchoepithelial expression of CXCR1 and/or CXCR2 facilitate transepithelial migration of neutrophils. |
### Instruction:
Is current or recent pregnancy associated with adverse pathologic features but not impaired survival in early breast cancer?
### Response:
| PABC is associated with more adverse tumor features than non-PABC matched for age and year of diagnosis. After correcting for pathologic features, the diagnosis of PABC is not in itself an adverse prognostic factor for survival. |
### Instruction:
Is permanent hypopituitarism rare after structural traumatic brain injury in early childhood?
### Response:
| Permanent hypopituitarism is rare after both inflicted and accidental structural TBI in early childhood. Precocious puberty was the only pituitary hormone abnormality found, but the prevalence did not exceed that of the normal population. |
### Instruction:
Do [ Stability of Le Fort I impaction osteotomies ]?
### Response:
| Impaction maxillary osteotomy provides stable bone results for maxillary facial height excess. Unsatisfactory outcome is always due to postoperative dental and alveolar displacement. These results correlate to published data. |
### Instruction:
Is [ Contact with the child and adolescent psychiatric services determined by cultural and socio-economic differences ]?
### Response:
| Access to the child and adolescent psychiatric services is influenced by both ethnic and socio-cultural differences. |
### Instruction:
Is annual change in Friedreich 's ataxia evaluated by the Scale for the Assessment and Rating of Ataxia ( SARA ) independent of disease severity?
### Response:
| In adult Friedreich's ataxia patients the Scale for the Assessment and Rating of Ataxia can detect annual changes independently of disease severity. In future therapeutic trials no patient stratification is globally required. |
### Instruction:
Do individual variability and environmental characteristics influence older adults ' abilities to manage everyday technology?
### Response:
| Variability in intrapersonal capacities seems to be of more importance than the actual level of intrapersonal capacity in relation to the ability to manage ET for this sample. This implies that investigations of ability to manage ET should also include intraperson variability. Additionally, adaptations in environmental... |
### Instruction:
Is overexpression of TMPRSS4 in non-small cell lung cancer associated with poor prognosis in patients with squamous histology?
### Response:
| Our results demonstrate that TMPRSS4 has a role in the lung cancer development. The potential use of TMPRSS4 as a biomarker for lung cancer detection or as a predictor of patient's outcome warrants further investigation. |
### Instruction:
Do cancer stem cell and embryonic development-associated molecules contribute to prognostic significance in ovarian cancer?
### Response:
| Notch1, Jagged1, and Delta1 expressions might be useful markers for clinical prognosis of ovarian carcinomas; and Notch pathway, one of the most intensively studied putative therapeutic targets, may be a useful marker for cancer. Consequently, Jagged1 could be a marker for tumor grades and Notch1 as a marker for metast... |
### Instruction:
Is restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery associated with reduction in microparticles?
### Response:
| The reduction in microparticles after bariatric surgery in patients with type 2 diabetes mellitus reflects an attenuation of inflammation, and this mechanism might contribute to normalization of glycemic control. |
### Instruction:
Is sagital abdominal diameter , but not waist circumference strongly associated with glycemia , triacilglycerols and HDL-C levels in overweight adults?
### Response:
| Though the SAD and WC were associated with numerous metabolic abnormalities, only SAD correlated with dyslipidemia (TG and HDL-c) and hyperglycemia (glycemia). |
### Instruction:
Does zebularine suppress TGF-beta-induced lens epithelial cell-myofibroblast transdifferentiation by inhibiting MeCP2?
### Response:
| MeCP2 plays an important role in TGFβ2-induced α-SMA expression in lens epithelial cells. Zebularine could reverse the TGFβ2-induced α-SMA expression by inhibiting MeCP2 expression. Therefore, zebularine could potentially prevent PCO formation. |
### Instruction:
Does postnatal rosiglitazone administration to neonatal rat pups alter the young adult metabolic phenotype?
### Response:
| Treatment with RGZ in early neonatal life does not alter later developmental metabolic programming or lead to an altered metabolic phenotype in the young adult, further re-enforcing the safety of PPARγ agonists as a novel lung-protective strategy. |
### Instruction:
Is follicle-stimulating hormone independently associated with lean mass but not BMD in younger postmenopausal women?
### Response:
| After adjustment for hormonal measures and osteoporosis risk factors, higher concentrations of FSH were independently associated with lower lean mass, but not with BMD. Previously reported correlations between FSH and BMD might have been due to indirect associations via lean mass or weight. |
### Instruction:
Does light therapy by blue LED improve wound healing in an excision model in rats?
### Response:
| In contrast to previous studies, we showed that also blue light significantly influences wound healing. Furthermore, our data suggest that light therapy can play an important role in normotrophic wound healing by affecting keratin expression. Illumination would provide an easily applicable, safe and cost-effective trea... |
### Instruction:
Does heparin elevate circulating soluble fms-like tyrosine kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapy?
### Response:
| Heparin likely increases the maternal sFlt-1 through shedding of the extracellular domain of Flt-1 receptor. Our results imply that upregulation of circulating sFlt-1 immunoreactivity in pregnancy is not always associated with adverse outcomes, and that heparin's protective effects, if any, cannot be explained by promo... |
### Instruction:
Is use of alcohol-free antimicrobial mouth rinse associated with decreased incidence of preterm birth in a high-risk population?
### Response:
| A nonalcohol antimicrobial mouth rinse containing cetylpyridinium chloride was associated with decreased incidence of PTB <35 weeks. |
### Instruction:
Is cCR5 expression elevated on endocervical CD4+ T cells in healthy postmenopausal women?
### Response:
| Elevated cervical CCR5 expression in postmenopausal women may increase their risk for HIV-1 acquisition. Studies are needed to confirm whether elevated CCR5 expression confers increased HIV-1 susceptibility in postmenopausal women, and if it is related to hormonal or nonhormonal effects of aging. |
### Instruction:
Are immature muscle precursors a source of interferon-β in myositis : role of Toll-like receptor 3 activation and contribution to HLA class I up-regulation?
### Response:
| Immature muscle precursors may represent a local source of IFNβ and the target of an immune response involving activated DCs associated with the expression of CLRs and of IL-12 and IL-23, which are implicated in T cell polarization. In turn, such local production of IFNβ after TLR-3 activation in the presence of the Th... |
### Instruction:
Do functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model?
### Response:
| RGD functionalized PLGA nanoparticles encapsulating STAT1-targeted siRNAs are efficacious in the treatment of established arthritis, possibly through a selective inhibition of macrophage and dendritic cell activation. |
### Instruction:
Does β-AR blockers suppress ER stress in cardiac hypertrophy and heart failure?
### Response:
| Our results demonstrated that ER stress occurred in failing hearts and this could be reversed by β-AR blockade. Alleviation of ER stress may be an important mechanism underlying the therapeutic effect of β-AR blockers on heart failure. |
### Instruction:
Is depression associated with sarcopenia , not central obesity , in elderly korean men?
### Response:
| Depression in elderly Koreans is associated with low body mass and sarcopenia, especially in men. |
### Instruction:
Is rosiglitazone-induced mitochondrial biogenesis in white adipose tissue independent of peroxisome proliferator-activated receptor γ coactivator-1α?
### Response:
| These results indicate that in white adipose tissue PGC-1α is dispensable for basal and rosiglitazone-induced mitochondrial biogenesis but required for the rosiglitazone-induced expression of UCP1 and other brown adipocyte-specific markers. Our study suggests that PGC-1α is important for the appearance of brown adipocy... |
### Instruction:
Does tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulate cell motility?
### Response:
| Our results suggest that cortactin acts as a bridging molecule between actin filaments and focal adhesions. The cortactin N-terminus associates with F-actin, while its C-terminus interacts with focal adhesions. The tyrosine phosphorylation of cortactin by the FAK-Src complex modulates its interaction with FAK and incre... |
### Instruction:
Does preventive and therapeutic euphol treatment attenuate experimental colitis in mice?
### Response:
| Together, these results clearly demonstrated that orally-administered euphol, both preventive or therapeutic treatment were effective in reducing the severity of colitis in two models of chemically-induced mouse colitis and suggest this plant-derived compound might be a potential molecule in the management of inflammat... |
### Instruction:
Does dNA vaccination with a gene encoding Toxoplasma gondii GRA6 induce partial protection against toxoplasmosis in BALB/c mice?
### Response:
| Our result supports the concept that the acquired immune response is MHC restricted. This study has a major implication for vaccine designs using a single antigen in a population with diverse MHC class I alleles. |
### Instruction:
Do βC1 of chili leaf curl betasatellite is a pathogenicity determinant?
### Response:
| The results presented here show that the expression of βC1 of ChLCB from PVX vector exhibit phenotype typical of cotton leaf curl and therefore ChLCB may contribute to the disease symptoms. |
### Instruction:
Are compression stockings with moderate pressure able to reduce chronic leg oedema?
### Response:
| Compression stockings exerting a pressure of around 30 mmHg are nearly as effective as high-pressure bandages with an initial pressure over 60 mmHg in reducing chronic leg oedema. |
### Instruction:
Does c1-esterase inhibitor protect against early vein graft remodeling under arterial blood pressure?
### Response:
| C1inh significantly protects against early vein graft remodeling, including loss of endothelium and intimal thickening. These data suggest that it may be worth considering its use in patients undergoing coronary artery bypass grafting. |
### Instruction:
Does ubiquitination of Cdc20 by the APC occur through an intramolecular mechanism?
### Response:
| We show here that Cdc20 fluctuates through the cell cycle via a distinct form of APC-mediated ubiquitination. This in cis autoubiquitination may preferentially occur in early anaphase, following depletion of Cdc20 substrates. This suggests that distinct mechanisms are able to target Cdc20 for ubiquitination at differen... |
### Instruction:
Is greater resting heart rate variability associated with orgasms through penile-vaginal intercourse , but not with orgasms from other sources?
### Response:
| Findings are discussed in the context of orgasms through PVI enhancing HRV, and greater parasympathetic tone favoring the capacity to engage in PVI, and in the case of women, to reach vaginal orgasm. The possibility of healthier people having greater resting HRV and more frequent orgasms through specifically PVI is als... |
### Instruction:
Does tissue factor/factor VIIa pathway mediate coagulation activation in induced-heat stroke in the baboon?
### Response:
| Tissue factor/factor VIIa-dependent pathway initiates coagulation activation in induced-heat stroke in the baboon without an effect on fibrinolysis and inflammation. The findings suggest also that coagulation activation is not a prerequisite of cell injury and organ dysfunction. |
### Instruction:
Does nuclear factor-κB signaling contribute to mechanical ventilation-induced diaphragm weakness*?
### Response:
| Collectively, these findings support the hypothesis that nuclear factor-κB activation plays a significant signaling role in mechanical ventilation-induced diaphragmatic weakness and that oxidative stress is an upstream activator of nuclear factor-κB. Finally, our results suggest that prevention of mechanical ventilatio... |
### Instruction:
Is renal cell carcinoma in young patients associated with poorer prognosis?
### Response:
| Younger patients were more likely to have non-clear cell RCC with higher disease recurrence and lower OS. They should not be assumed to have similar features and outcomes as screen-detected early RCC in older patients. |
### Instruction:
Does hepatocyte growth factor induce resistance to anti-epidermal growth factor receptor antibody in lung cancer?
### Response:
| HGF-mediated resistance is a novel mechanism of resistance to EGFR Ab in lung cancers, with fibroblast-derived HGF inducing cetuximab resistance in H292 tumors in vivo. The involvement of HGF-Met-mediated signaling should be assessed in acquired resistance to EGFR Ab in lung cancer, regardless of EGFR gene status. |
### Instruction:
Is phospholipid transfer protein in the placental endothelium affected by gestational diabetes mellitus?
### Response:
| HPEC contribute to the release of active PLTP into the fetal circulation. Pltp expression is increased in GDM with hyperglycemia and/or hyperinsulinemia contributing. High PLTP activity in fetal serum may enhance conversion of HDL into cholesterol-accepting particles, thereby increasing maternal-fetal cholesterol trans... |
### Instruction:
Does [ Sevoflurane postconditioning attenuate myocardial apoptosis in isolated rat hearts via a modulation of Bcl-2 family proteins ]?
### Response:
| Sevoflurane postconditioning may improve myocardial functions, reduce infarct size and attenuate myocardial apoptosis. And the modulated expression of apoptotic proteins plays an important role in sevoflurane-induced myocardial protection. |
### Instruction:
Does the combination of resveratrol and CLA increase the delipidating effect of each molecule in 3T3-L1 adipocytes?
### Response:
| Lipolysis increase via ATGL is involved in the TG reduction induced by resveratrol and the combination of both molecules. The combination of these two molecules does not increase the efficacy of each molecule separately in mature adipocytes and thus it does not represent an advantage for obesity treatment or prevention... |
### Instruction:
Does previous overt hepatic encephalopathy rather than minimal hepatic encephalopathy impair health-related quality of life in cirrhotic patients?
### Response:
| These data suggest that previous bouts of HE, despite their complete clinical resolution, play an independent role in producing a persistent impairment in HRQoL of cirrhotics. |
### Instruction:
Does long-term adefovir plus lamivudine therapy decrease creatinine clearance in HBeAg-negative chronic hepatitis B patients?
### Response:
| Adefovir and lamivudine combination therapy is not an independent factor for significant renal dysfunction in HBeAg-negative patients with lamivudine-resistance. Baseline age and creatinine clearance are the only independent predictors of worsening renal function. |
### Instruction:
Does leptin produced by joint white adipose tissue induce cartilage degradation via upregulation and activation of matrix metalloproteinases?
### Response:
| Leptin acts as a pro-inflammatory adipokine with a catabolic role on cartilage metabolism via the upregulation of proteolytic enzymes and acts synergistically with other pro-inflammatory stimuli. This suggests that the infrapatellar fat pad and other WAT in arthritic joints are local producers of leptin, which may cont... |
### Instruction:
Does inhibition of the p38 MAPK pathway ameliorate renal fibrosis in an NPHP2 mouse model?
### Response:
| These results suggest that inhibition of p38 MAPK reduced renal fibrosis but not cyst expansion, cell proliferation and apoptosis in NPHP2 model mice. Our results suggest that p38 MAPK and ERK signaling pathways independently affect renal fibrosis in inv mutant mice. |
### Instruction:
Are high-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat ameliorated by fenofibrate through the PPARα-FoxO3a-PGC-1α pathway?
### Response:
| Our results demonstrated that PPARα agonists or antioxidants are associated with improvement of the circulating FFA and TGs levels and this prevents HFD-induced renal lipotoxicity and hypertension by the activation of PPARα and its downstream signals of both FoxO3a and PGC-1α. |
### Instruction:
Does rituximab abrogate joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis?
### Response:
| Rituximab treatment is associated with a decrease in synovial osteoclast precursors and RANKL expression and an increase in the osteoprotegerin/RANKL ratio in serum. These observations may partly explain the protective effect of rituximab on the progression of joint destruction in RA. |
### Instruction:
Is insulin resistance a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome?
### Response:
| In the present study, we show that LD may be a model for the common forms of PCOS and that the endocrine features are corrected by leptin therapy, which reduces insulin resistance. |
### Instruction:
Are hyaluronan serum concentrations elevated in critically ill patients and associated with disease severity?
### Response:
| Measurement of serum HA may supplement the assessment of disease severity in ICU patients. Our data suggest that HA might have implications in the pathogenesis of critical illness and sepsis. |
### Instruction:
Do enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA?
### Response:
| By exploring the spatial organization of the Kcnq1 locus, our results reveal a novel mechanism by which local activation of genes can override the regional silencing effects of non-coding RNAs. |
### Instruction:
Does shift climate profiles and correlate in acute psychiatric inpatient units?
### Response:
| The day-to-day social-emotional climate can have important consequences for patient engagement and recovery. Improved understanding of the role played by unit, staff and patient characteristics, together with routine monitoring, should facilitate the development and evaluation of targeted interventions to reduce advers... |
### Instruction:
Are common variants of GSTP1 , GSTA1 , and TGFβ1 associated with the risk of radiation-induced fibrosis in breast cancer patients?
### Response:
| These results suggest that functional variations in genes involved in oxidative stress response and fibroblast proliferation may modulate the development of radiation-induced fibrosis in breast cancer patients. The results of the combined analysis support the notion that approaches based on the combination of different... |
### Instruction:
Does curcumin protect against ischemia/reperfusion injury in rat skeletal muscle?
### Response:
| In this study, protective effects of curcumin against skeletal muscle ischemia-reperfusion injury have been revealed. We underscore the necessity of human studies with curcumin that would be hypothetically beneficial preventing skeletal muscle I/R injury. |
### Instruction:
Do clinical and histopathological outcomes of subconjunctival triamcinolone injection for the treatment of acute ocular alkali burn in rabbits?
### Response:
| Subconjunctival injection of triamcinolone may be a therapeutic option for the treatment of acute ocular burn because it reduced the corneal inflammatory process, opacity, and vascularization, with no apparent clinical changes in the general state of the animal. |
### Instruction:
Do cCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis?
### Response:
| CCR9(+) macrophages contribute to the induction of acute liver inflammation in mouse models of hepatitis. |
### Instruction:
Are triglycerides independently associated with albuminuria in Taiwanese Type 2 diabetic patients?
### Response:
| We conclude that TG increases significantly throughout the 3 stages of albuminuria in Taiwanese Type 2 diabetic patients, but TC, HDL-C, and LDL-C do not. |
### Instruction:
Does splenectomy offer immunological benefits in ABO-incompatible liver transplantation with a preoperative rituximab?
### Response:
| Preoperative rituximab effectively decreased the anti-ABO antibodies sufficiently to prevent the AMR irrespective of splenectomy. Splenectomy does not offer any immunological benefit in ABO-I LT with preoperative rituximab. |
### Instruction:
Are patients with CD36 deficiency associated with enhanced atherosclerotic cardiovascular diseases?
### Response:
| The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic. |
### Instruction:
Do no association of diabetic duration or insulin use with the prognosis of critical limb ischemia after endovascular therapy?
### Response:
| Diabetic duration and insulin use were not independent risk factors for the prognosis of CLI after endovascular therapy. |
### Instruction:
Does mannose-binding lectin contribute to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection?
### Response:
| Our study provided the first in vivo evidence that MBL may be a risk factor during pdmH1N1 and H9N2/G1 infection by upregulating proinflammatory response. |
### Instruction:
Does identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicate the existence of potential asymptomatic infections?
### Response:
| This is the first report of ex vivo H5 HA-specific T-cell responses in a healthy but H5N1-exposed population. Our results indicate that the presence of H5N1-specific T cells could be an additional diagnostic tool for asymptomatic H5N1 infection. |
### Instruction:
Do [ Multidisciplinary meetings in oncology impact the physician-patient relationship ]?
### Response:
| MDM appears in most cases in this study not to modify the patient-physician relationship. Due to the patient confidence into the referring physician, the role of this one is essential in integrating the decisional multidisciplinary opinion of MDM and it is important to ensure from his/her disengagement in the decisiona... |
### Instruction:
Do clinicopathologic and gene expression parameters predict liver cancer prognosis?
### Response:
| When applied individually, clinicopathologic parameters and gene expression offered similar predictive power for HCC prognosis. In contrast, a combination of the two types of data dramatically improved the power to predict HCC prognosis. Our results also provided a framework for understanding the impact of gene express... |
### Instruction:
Does discoidin domain receptor 2 deficiency predispose hepatic tissue to colon carcinoma metastasis?
### Response:
| DDR2 deficiency fosters the myofibroblast transdifferentiation of tumour-activated HSCs, generating a prometastatic microenvironment in the liver via HSC-derived factors. These findings underscore the role of stromal cells in conditioning the hepatic microenvironment for metastases through altered receptor-stroma inter... |
### Instruction:
Does expression of Smad7 inhibit fibrogenic responses of keratocytes to transforming growth factor β2?
### Response:
| Smad7 gene transfer inhibited fibrogenic responses of keratocytes to TGFβ2. |
### Instruction:
Is molecular biomarker of inflammatory response associated with rebleeding in spontaneous intracerebral hemorrhage?
### Response:
| These data suggest that IL-10, a molecular biomarker of inflammatory response in the early acute phase of ICH, is associated with subsequent rebleeding. |
### Instruction:
Are urinary concentrations of 15-epimer of lipoxin A ( 4 ) lower in patients with aspirin-intolerant compared with aspirin-tolerant asthma?
### Response:
| We have demonstrated for the first time that urinary 15-epi-LXA(4) concentration is significantly higher than LXA(4) concentration in both the AIA and ATA groups. 15-Epi-LXA(4) concentration was significantly lower in the AIA group with an increased urinary LTE(4) concentration than in the ATA group. An imbalance betwe... |
### Instruction:
Does casticin-induced apoptosis involve death receptor 5 upregulation in hepatocellular carcinoma cells?
### Response:
| Casticin-induced apoptosis of HCC cells is involved in GSH depletion and DR5 upregulation. |
### Instruction:
Is intraoperative frozen section essential for assessment of myometrial invasion but not for histologic grade confirmation in endometrial cancer : a ten-year experience?
### Response:
| Evaluation of the histologic grade by EB and of the depth of myometrial invasion by intraoperative biopsy is a good option for deciding the necessity of lymphadenectomy. |
### Instruction:
Does combined treatment with a nonablative infrared device and hyaluronic acid filler have enhanced efficacy in treating nasolabial fold wrinkles?
### Response:
| Combining the use of a nonablative IR device with HA filler does not appear to be superior to HA filler alone in the treatment of moderate to severe NLF wrinkles. |
### Instruction:
Do why caretakers bypass Primary Health Care facilities for child care - a case from rural Tanzania?
### Response:
| The observation that people are willing to travel long distances to get better quality services calls for health policies that prioritize quality of care before quantity. In a situation with limited resources, utilizing available resources to improve quality of care at available facilities could be more appropriate for... |
### Instruction:
Is mMP-8 -799 C > T genetic polymorphism associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese?
### Response:
| These results suggested that non-smoking Taiwanese with the MMP-8 -799 T allele were associated with the risks of both CP and AgP. Further studies in other ethnic populations are necessary. |
### Instruction:
Do nurses provide valuable proxy assessment of the health-related quality of life of children with Hodgkin disease?
### Response:
| Over the course of treatment for Hodgkin disease, there was substantial agreement among the parent's, nurse's, and children's reported HRQL scores. Nurses contribute valuable additional information as proxy respondents. |
### Instruction:
Is postcarotid endarterectomy improvement in cognition associated with resolution of crossed cerebellar hypoperfusion and increase in 123I-iomazenil uptake in the cerebral cortex : a SPECT study?
### Response:
| Resolution of CCH and increase in (123)I-IMZ uptake in the ipsilateral cerebral cortex after CEA is associated with postoperative improvement in cognitive function. These results may indicate that cognitive impairment is related to a state of potentially reversible central benzodiazepine receptor downregulation in the ... |
### Instruction:
Does [ Huangqi decoction inhibit cholangiocyte proliferation and transdifferentiation in cholestatic liver fibrosis induced by BDL in rats ]?
### Response:
| These observations suggest that Huangqi decoction can inhibit cholangiocyte proliferation and cholangiocyte transdifferentiation. |
### Instruction:
Does estradiol inhibit chondrogenic differentiation of mesenchymal stem cells via nonclassic signaling?
### Response:
| The experiments revealed a suppression of chondrogenesis by estradiol via membrane receptors (GPR-30). The study opens new perspectives for influencing chondrogenesis on the basis of classic and nonclassic estradiol signaling. |
### Instruction:
Does microRNA-27b regulate the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes?
### Response:
| Our data demonstrated the expression of miR-27b in both normal and OA chondrocytes. Furthermore, IL-1beta-induced activation of signal transduction pathways associated with the expression of MMP-13 down-regulated the expression of miR-27b. Thus, miR-27b may play a role in regulating the expression of MMP-13 in human ch... |
### Instruction:
Does mast cell-derived tryptase inhibit apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling?
### Response:
| These results demonstrate that tryptase has a strong antiapoptotic effect on RASFs through the activation of Rho. Thus, we propose that the release of tryptase by mast cells leads to the binding of tryptase to PAR-2 on RASFs and inhibits the apoptosis of RASFs via the activation of Rho. Such mechanisms could play a piv... |
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