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### Instruction:
Are tumor necrosis factor-alpha promoter polymorphisms associated with idiopathic primary ovarian insufficiency in Korean women?
### Response:
| The TNF-α -1031C and -238A alleles had strong association with POI. The TNF-α -308A allele showed limited significance for POI risk with the presence of the -1031T allele. Our data suggest that the minor alleles of TNF-α promoter polymorphisms may increase POI risk in Korean women. |
### Instruction:
Is abdominal muscle feedforward activation in patients with chronic low back pain largely unaffected by 8 weeks of core stability training?
### Response:
| Abdominal muscle onset was largely unaffected by 8 weeks of exercises in chronic LBP patients with changes in onset of less than 20 milliseconds between groups. |
### Instruction:
Is the ratio of visceral to subcutaneous fat , a metric of body fat distribution , a unique correlate of cardiometabolic risk?
### Response:
| VAT/SAT ratio is a correlate of cardiometabolic risk, above and beyond BMI and VAT. The propensity to store fat viscerally versus subcutaneously may be a unique risk factor independent of absolute fat volumes. |
### Instruction:
Does wortmannin reduce metastasis and angiogenesis of human breast cancer cells via nuclear factor-κB-dependent matrix metalloproteinase-9 and interleukin-8 pathways?
### Response:
| The findings of the present study suggest that wortmannin inhibits metastasis and angiogenesis in breast cancer cells via PI3K/Akt/NF-κB-mediated MMP-9 and IL-8 signalling pathways. |
### Instruction:
Do epidural analgesia and laparoscopic technique reduce incidence of prolonged ileus in elective colon resections?
### Response:
| The incidence of prolonged ileus was similar in the 3 groups studied. However, the epidural and laparoscopic groups experienced earlier return of bowel function and toleration of diet than the nonepidural group. |
### Instruction:
Do left cardiac chambers reverse remodeling after percutaneous mitral valve repair with the MitraClip system?
### Response:
| The present study reports positive LV reshape effects after mitral valve repair with the MitraClip system, showing significant improvements in LV size and function. |
### Instruction:
Do changes in estimated right ventricular systolic pressure predict mortality and pulmonary hypertension in a cohort of scleroderma patients?
### Response:
| In a population of scleroderma patients, the rate of increase in RVSP is a risk factor for mortality and PAH even after adjustment for clinical characteristics and longitudinal PFT data. |
### Instruction:
Does sHP-2 phosphatase promote cervical cancer cell proliferation through inhibiting interferon-β production?
### Response:
| SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting IFN-β production. |
### Instruction:
Is periventricular nodular heterotopia related to severity of the hindbrain deformity in Chiari II malformation?
### Response:
| Periventricular nodular heterotopia was seen in a relatively high proportion of children with Chiari II malformation, suggesting that it may be associated with severe hindbrain deformity. |
### Instruction:
Is prostatic fibrosis associated with lower urinary tract symptoms?
### Response:
| Findings show that extracellular matrix deposition and fibrosis characterize the periurethral prostate tissue of some men with lower urinary tract symptoms. They point to fibrosis as a factor contributing to lower urinary tract symptom etiology. |
### Instruction:
Is routine barium enema prior to closure of defunctioning ileostomy necessary?
### Response:
| Routine barium enema evaluation of low pelvic anastomoses before loop ileostomy closure did not provide any additional information for postoperative colorectal anastomotic complication. |
### Instruction:
Is overexpression of BMI-1 associated with poor prognosis in cervical cancer?
### Response:
| The high expression of BMI-1 in cervical cancer is related to tumor progression, lymph node metastasis and HPV infection, suggesting that cervical cancer with excessive BMI-1 expression possesses high metastases potential and that BMI-1 may be a promising biomarker for predicting metastasis in cervical cancer. |
### Instruction:
Is overexpression of metadherin/MTDH associated with an aggressive phenotype and a poor prognosis in invasive breast cancer?
### Response:
| MTDH overexpression contributes to an aggressive phenotype, thus leading to a poor prognosis for primary invasive breast cancer. |
### Instruction:
Does addition of adrenaline to chloroprocaine provide a moderate duration time for epidural anaesthesia in elective caesarean section?
### Response:
| Epidural anaesthesia using chloroprocaine with adrenaline has a quick onset and moderate duration and is an attractive alternative to lidocaine and adrenaline or chloroprocaine alone for caesarean section. |
### Instruction:
Is extracellular matrix metalloproteinase inducer associated with severity of brain oedema following experimental subarachnoid haemorrhage in rats?
### Response:
| EMMPRIN upregulation may be important in the formation of brain oedema; inhibition of EMMPRIN activity may provide a potential approach to reduce oedema after subarachnoid haemorrhage. |
### Instruction:
Is fruit drink consumption associated with overweight and obesity in Canadian women?
### Response:
| Using a nationally representative dataset, there was an association between sugar-sweetened beverages and overweight and obesity in Canadian women. |
### Instruction:
Do mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis?
### Response:
| These data demonstrate that iPSC-MSCs are capable of modulating T-cell phenotypes towards Th2 suppression through inducing Treg expansion, suggesting that iPSC-MSCs can be used as an alternative candidate to adult MSCs to treat allergic airway diseases. |
### Instruction:
Does use of porous trabecular metal augment with impaction bone grafting in management of acetabular bone loss?
### Response:
| This study shows that trabecular metal augments are effective in filling the bone defect and provide a stable foundation for impaction bone grafting. We found satisfactory clinical and radiographic results using this technique, with low failure rate at a median follow-up time of 5 years. |
### Instruction:
Is obesity underestimated using body mass index and waist-hip ratio in long-term adult survivors of childhood cancer?
### Response:
| Sixteen years after treatment for childhood cancer, the increase in BMI and total fat percentage was significantly greater than expected, especially after CRT. This is important as we could show that obesity was grossly underestimated using BMI and waist-hip ratio. |
### Instruction:
Does sulforaphane inhibit restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells?
### Response:
| Our results indicate that sulforaphane inhibits neointima formation via targeting of adhesion molecules through the suppression of NF-κB/GATA6. Furthermore, sulforaphane regulates migration and proliferation in VSMCs. Sulforaphane may be a potential therapeutic agent for preventing restenosis after vascular injury. |
### Instruction:
Does receptor for activated C kinase 1 promote hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity?
### Response:
| Overexpressed RACK1 augments JNK activity and thereby promotes HCC growth through directly binding to MKK7 and enhancing MKK7 activity. |
### Instruction:
Is interstitial magnetic resonance lymphography an effective diagnostic tool for the detection of lymph node metastases in patients with cervical cancer?
### Response:
| Interstitial MR lymphography can be used to determine the extent and shape of pelvic lymphatic vessel drainage and lymph node metastases in patients with cervical cancer. |
### Instruction:
Is interleukin-6 the strongest predictor of 30-day mortality in patients with cardiogenic shock due to myocardial infarction?
### Response:
| In patients with MI complicated by CS, IL-6 represented a reliable independent early prognostic marker of 30-day mortality. PCT revealed a significant value at later points in time, whereas Nt-proBNP seemed to be of lower relevance. |
### Instruction:
Do microstructural abnormalities of white matter differentiate pediatric and adult-onset bipolar disorder?
### Response:
| The ALIC connects the frontal lobes with archistriatum, thalamus, and medial temporal regions, and alteration in these pathways may contribute to mood dysregulation in BD. Abnormalities in this pathway appear to be associated with an earlier onset of illness and thus may reflect a greater susceptibility to illness. |
### Instruction:
Do haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene influence protein level in the gingival crevicular fluid?
### Response:
| The IL8 haplotype of susceptibility to CP was neither associated with IL-8 cytokine levels nor with clinical periodontal parameters. Also, CP, IL8 haplotype and IL-8 concentration showed a positive association with the GCF volume levels in the studied patients. |
### Instruction:
Is cruciferous vegetables intake inversely associated with risk of breast cancer : a meta-analysis?
### Response:
| Findings from this meta-analysis suggest that cruciferous vegetables consumption may reduce the risk of breast cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of cruciferous vegetables on breast cancer. |
### Instruction:
Does subclinical haemorrhagic tendency exist in patients with β-thalassaemia major in early childhood?
### Response:
| The findings from this study suggest that a subclinical haemorrhagic tendency exists in patients with β-TM at a very early age. The intrinsic pathway appears to be more affected than the extrinsic pathway. |
### Instruction:
Does aVE3085 protect coronary endothelium from the impairment of asymmetric dimethylarginine by activation and recoupling of eNOS?
### Response:
| AVE3085 prevents ADMA-induced endothelial dysfunction in coronary arteries. The protective effect of AVE3085 may be attributed to increased NO production resulting from enhanced eNOS activation, and decreased oxidative stress that involves inhibition of O (2) (.-) generation by eNOS recoupling. The present study suggested the therapeutic potential of AVE3085 in endothelial dysfunction in cardiovascular disorders. |
### Instruction:
Does the novel NOX inhibitor 2-acetylphenothiazine impair collagen-dependent thrombus formation in a GPVI-dependent manner?
### Response:
| Taken together, our results suggest that 2-APT attenuates GPVI-specific signalling and is a novel inhibitor of collagen-induced platelet responses. Therefore, NOXs could represent a novel target for the discovery of anti-thrombotic drugs. |
### Instruction:
Does long-term oxytocin administration improve social behaviors in a girl with autistic disorder?
### Response:
| This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs. |
### Instruction:
Are cartilage oligomeric matrix protein specific antibodies pathogenic?
### Response:
| We have identified the specificities of mAbs to COMP and their contribution to the development of arthritis. These findings will further improve our understanding of the autoantibody mediated immunopathologies occurring widely in rheumatoid arthritis (RA), as well as in other autoimmune disorders. |
### Instruction:
Is abnormal glucose metabolism associated with reduced left ventricular contractile reserve and exercise intolerance in patients with chronic heart failure?
### Response:
| Diabetes, known or newly detected by OGTT, is independently associated with reduced LV contractile reserve and exercise intolerance in outpatients with systolic HF. These findings may offer one explanation for the excess mortality related to diabetes in HF. |
### Instruction:
Are expression of matrix macromolecules and functional properties of breast cancer cells modulated by the bisphosphonate zoledronic acid?
### Response:
| The obtained results demonstrate that zoledronate is a critical modulator of ECM gene expression and powerful anticancer agent inhibiting growth, migration and the matrix-associated invasion of breast cancer cells. |
### Instruction:
Does microbeam-irradiated tumour tissue possess a different infrared absorbance profile compared to broad beam and sham-irradiated tissue?
### Response:
| The lack of difference between MRT peak and valley irradiated areas suggests a holistic tissue response to MRT that occurs within 4 h, and might be the first evidence for a mechanism by which MRT kills the whole tumour despite only a small percentage receiving peak irradiation. |
### Instruction:
Does digital music exposure reliably induce temporary threshold shift in normal-hearing human subjects?
### Response:
| These data provide insight into the variability of TTS induced by music-player use in a healthy, normal-hearing, young adult population, with music playlist, level, and duration carefully controlled. These data confirm the likelihood of temporary changes in auditory function after digital music-player use. Such data are essential for the development of a human clinical trial protocol that provides a highly powered design for evaluating novel therapeutics in human clinical trials. Care must be taken to fully inform potential subjects in future TTS studies, including protective agent evaluations, that some noise exposures have resulted in neural degeneration in animal models, even when both audiometric thresholds and DPOAE levels returned to pre-exposure values. |
### Instruction:
Are specific histological abnormalities more likely in biopsies of endoscopically normal large bowel after the age of 60 years?
### Response:
| Biopsy of an endoscopically normal large bowel, and of the normal terminal ileum in isolation, yields little abnormal histology. Diarrhoea per se does not identify patients at higher risk of abnormal histology. Increased age, however, does, and mucosal biopsy in the endoscopically normal colon and rectum may be more cost-effective in patients aged more than 60 years. |
### Instruction:
Does long-term eculizumab improve clinical outcomes in atypical hemolytic uremic syndrome?
### Response:
| Chronic eculizumab treatment was associated with control of complement-mediated TMA and sustained long-term improvement in renal and cardiac function. |
### Instruction:
Does the novel orally active guanylhydrazone CPSI-2364 prevent postoperative ileus in mice independently of anti-inflammatory vagus nerve signaling?
### Response:
| Orally administered CPSI-2364 shows a near-exclusive dispersal in the gastrointestinal tract and effectively reduces POI independently of central vagus nerve stimulation. Its efficacy after single oral dosage affirms CPSI-2364 treatment as a promising strategy for prophylaxis of POI. |
### Instruction:
Is dietary salt intake related to inflammation and albuminuria in primary hypertensive patients?
### Response:
| These findings suggest that high salt intake is associated with enhanced inflammation and target organ damage reflected by increased albuminuria in treated hypertensive patients independent of any BP effect. |
### Instruction:
Does increased electroencephalographic gamma activity reveal awakening from isoflurane anaesthesia in rats?
### Response:
| The increase in frontal relative gamma activity, especially in the 50-150 Hz frequency band, seems to be the most reliable EEG indicator for the awakening of a rat from isoflurane anaesthesia. A number of other spectral measures can also be used to detect this event. However, the role of gamma frequencies in the performance of these parameters is crucial. |
### Instruction:
Does the prevalence and correlate of habitual snoring during pregnancy?
### Response:
| Identification of risk factors for habitual snoring during pregnancy has important implications for developing strategies aimed at reducing the prevalence of sleep-disordered breathing, promoting improved sleep hygiene and improved pregnancy outcomes among reproductive-age women. |
### Instruction:
Does targeting mannose-binding lectin confer long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia?
### Response:
| Our data show an important role for MBL in the pathogenesis of brain ischemic injury and provide a strong support to the concept that MBL inhibition may be a relevant therapeutic target in humans, one with a wide therapeutic window of application. |
### Instruction:
Is priapism associated with sleep hypoxemia in sickle cell disease?
### Response:
| Oxyhemoglobin desaturation during sleep was associated with priapism history. It may underlie the distribution pattern of penile rigidity events during sleep in these patients. |
### Instruction:
Does curcumin 's pre-incubation temperature affect its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme?
### Response:
| The addition of thermally pre-treated curcumin was found to attenuate the formation of HEWL fibrils and the observed fibrillation inhibition was dependent upon the pre-incubation temperature of curcumin. Our results also demonstrated that the cytotoxic effects of fibrillar HEWL species on PC 12 and SH-SY5Y cells were decreased and negatively correlated with curcumin's thermostability. Next, an enhanced stability of HEWL was perceived upon the addition of curcumin pre-incubated at lower temperature. Furthermore, we found that the alteration of curcumin's thermostability was associated with its inhibitory potency against HEWL fibrillation. |
### Instruction:
Does adenoviremia have limited clinical impact in the majority of patients following alemtuzumab-based allogeneic stem cell transplantation in adults?
### Response:
| We detected adenoviremia at quantifiable levels in only 12.1% of HSCT patients. Attributable mortality was low (0.9% of the entire cohort, 7% of those with adenoviremia) because even infections associated with high viral titers responded to reduction in immunosuppression and treatment with cidofovir in the majority. The clinical significance of adenoviral infection in patients receiving alemtuzumab-based HSCT appears to be less than that previously reported, and only rarely does infection lead to significant morbidity and mortality. |
### Instruction:
Is apolipoprotein B-48 to triglyceride ratio a novel and useful marker for detection of type III hyperlipidemia after antihyperlipidemic intervention?
### Response:
| The apo B-48/TG ratio is a novel and useful marker for detecting type III HL even after the initiation of lipid-lowering interventions. |
### Instruction:
Are gender differences associated with the clinical features of systemic lupus erythematosus?
### Response:
| Early recognition of risk factors and appropriate intervention are essential, which might lead to high disease activity and serious systemic damage in male SLE patients. |
### Instruction:
Does exome sequencing identify compound heterozygous PKHD1 mutations as a cause of autosomal recessive polycystic kidney disease?
### Response:
| We identified that the compound heterozygous PKHD1 gene mutations are the molecular basis of the patient with ARPKD. Targeted exome sequencing is suitable for genetic diagnosis of single-gene inherited diseases like ARPKD in which the pathogenic gene is a large. |
### Instruction:
Does nonfluoroscopic mapping reduce radiation exposure in ablation of atrial fibrillation?
### Response:
| A fast nonfluoroscopic electroanatomical mapping system may reduce radiation exposure in RFCA of atrial fibrillation, with preserved success rates. |
### Instruction:
Are asthma beliefs associated with medication adherence in older asthmatics?
### Response:
| Illness and treatment beliefs have a strong influence on self-reported medication adherence in older asthmatics. Interventions to improve medication adherence in older asthmatics by modifying illness and treatment beliefs warrant study. |
### Instruction:
Does yes-associated protein regulate the hepatic response after bile duct ligation?
### Response:
| Our data suggest that YAP promotes cholangiocyte and hepatocyte proliferation and prevents parenchymal damage after cholestatic injury in mice and thus may mediate the response to cholestasis-induced human liver disease. |
### Instruction:
Does evaluation of antitumor activity of Mimusops elengi leave on Ehrlich 's ascites carcinoma-treated mice?
### Response:
| MEME showed significant (p < .001) decrease in tumor volume, packed cell volume, and viable cell count, and increased the life span of EAC bearing mice. Hematological, biochemical profile, and in vivo antioxidant parameters were significantly restored toward normal levels in MEME-treated mice as compared to EAC control. MEME also showed direct cytotoxicity on EAC cell line in a dose-dependent manner. |
### Instruction:
Are sequence memory skills in Spastic Bilateral Cerebral Palsy age independent as in normally developing children?
### Response:
| Sequence memory skills should be verified to plan therapeutic strategies. Therapeutic plans based on implicit learning (more resistant to disruption and stress) could be effective and highly advantageous for most but not for all CP children. Independently from age, many CP children could fix sequences more efficiently by explicit strategies, a more effortful but probably more effective way. |
### Instruction:
Is the Marburg I polymorphism of factor VII activating protease associated with low proteolytic and low pro-coagulant activity?
### Response:
| Most likely TFPI cleavage by WT-FSAP occurs in vivo and contributes to an elevated level of endogenous FVIIa. This may explain why MI-FSAP is not a clear indicator for deep vein thrombosis in population studies. The loss of the pro-fibrinolytic protective function of FSAP in carriers of the MI-SNP may account for the association of the MI-SNP with atherosclerosis and thromboembolic complications. |
### Instruction:
Are novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors?
### Response:
| These data identify mGluR5 receptors on D1-expressing neurons as a common molecular substrate of novelty-seeking behaviors and behaviors associated with alcohol abuse. |
### Instruction:
Is resistance to platinum-based chemotherapy associated with epithelial to mesenchymal transition in epithelial ovarian cancer?
### Response:
| Some genes involved in EMT were associated to overall or progression free survival, suggesting EMT as vital to the resistance mechanisms. |
### Instruction:
Is body fat associated with increased and lean mass with decreased knee cartilage loss in older adults : a prospective cohort study?
### Response:
| Body fat adversely affects tibial cartilage loss over time, whereas lean mass is protective. Strategies aimed at reducing body fat but increasing lean mass may reduce knee cartilage loss in older people. |
### Instruction:
Does genetic variation in the vaspin gene affect circulating serum vaspin concentrations?
### Response:
| Our data show that the variability in serum vaspin concentrations might be explained by its genetic variants. |
### Instruction:
Does quantitative analysis of light-phase restricted feeding reveal metabolic dyssynchrony in mice?
### Response:
| Collectively, these data suggest that weight gain following light (sleep)-phase restricted feeding is associated with significant alterations in energy balance, as well as dyssynchrony between metabolically active organs. |
### Instruction:
Does neurotrophic artemin promote motility and invasiveness of MIA PaCa-2 pancreatic cancer cells?
### Response:
| Artemin and its receptor GFRα3 can promote pancreatic cancer cell motility and invasiveness and contribute to aggressive behavior. The mechanism may be related to increased expression of MMP-2 molecule and down-regulation of E-cadherin expression. |
### Instruction:
Does torsional anomalous retinal correspondence effectively expand the visual field in hemianopia?
### Response:
| Torsional strabismus with anomalous retinal correspondence, when occurring with homonymous hemianopia provides useful field expansion in the lower and upper fields. Dichoptic perimetry permits documentation of ocular alignment (lateral, vertical, and torsional) and perceived visual direction under binocular and monocular viewing conditions. Evaluating patients with congenital or early strabismus for HARC is useful when considering surgical correction, particularly in the presence of congenital homonymous hemianopia. |
### Instruction:
Are src and Syk targeted to an anti-inflammatory ethanol extract of Aralia continentalis?
### Response:
| Ac-EE may be developed as a functional herbal remedy targeting Syk- and Src-mediated anti-inflammatory mechanisms. Future work using pre-clinical studies will be needed to investigate this possibility. |
### Instruction:
Does postnatal depression mediate the relationship between infant and maternal sleep disruption and family dysfunction?
### Response:
| Results are consistent with the proposition that identification of both infant and maternal sleep problems during infancy can be relevant to reduction of PND and improved family functioning. |
### Instruction:
Does inferring transcriptional gene regulation network of starch metabolism in Arabidopsis thaliana leave using graphical Gaussian model?
### Response:
| In this study, we utilized a systematic approach of microarray analysis to discover the transcriptional regulatory network of starch metabolism in Arabidopsis leaves. With this inference method, the starch regulatory network of Arabidopsis was found to be strongly associated with clock genes and TFs, of which AtIDD5 and COL were evidenced to control SS4 gene expression and starch granule formation in chloroplasts. |
### Instruction:
Are aspects of culturally competent care associated with less emotional burden among patients with diabetes?
### Response:
| Patient report of better doctor communication behavior and higher trust in physician are inversely associated with high EB among patients with diabetes. Further research should determine whether interventions improving patient physician communication and trust can lower the EB of diabetes. |
### Instruction:
Does history of weight cycling impede future weight loss or metabolic improvements in postmenopausal women?
### Response:
| A history of weight cycling does not impede successful participation in lifestyle interventions or alter the benefits of diet and/or exercise on body composition and metabolic outcomes. |
### Instruction:
Do acute hyperinsulinemia and reduced plasma free fatty acid levels decrease intramuscular triglyceride synthesis?
### Response:
| Fatty acid availability is a determinant of intramuscular TG synthesis. Insulin infusion decreases plasma and intramuscular fatty acid availability and thereby decreases TG synthesis. |
### Instruction:
Are sustained and shorter bouts of physical activity related to cardiovascular health?
### Response:
| Our cross-sectional observations on a large middle-age community-based sample confirm a positive association of MVPA with a healthier CVD risk factor profile and indicate that accruing PA in bouts <10 min may favorably influence cardiometabolic risk. Additional investigations are warranted to confirm our findings. |
### Instruction:
Is 25 ( OH ) vitamin D associated with greater muscle strength in healthy men and women?
### Response:
| These data suggest that there may be a differential effect of vitamin D on upper and lower body strength. The mechanism for this difference remains unclear but could be related to differences in androgenic effects or to differences in vitamin D receptor expression. Our study supports a direct relation between vitamin D and muscle strength and suggests that vitamin D supplementation be evaluated to determine whether it is an effective therapy to preserve muscle strength in adults. |
### Instruction:
Is lipid profile associated with the incidence of cognitive dysfunction in viral cirrhotic patients : A data-mining analysis?
### Response:
| The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision-tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid profile could be a possible screening bioparameter for CD in cirrhotic patients. |
### Instruction:
Does indoxyl sulfate predict cardiovascular disease and renal function deterioration in advanced chronic kidney disease?
### Response:
| Our results suggest that serum indoxyl sulfate level was a valuable marker in predicting cardiovascular disease and renal function decline in patients with advanced chronic kidney disease. |
### Instruction:
Is a corpus of full-text journal articles a robust evaluation tool for revealing differences in performance of biomedical natural language processing tools?
### Response:
| The finding that some systems were able to train high-performing models based on this corpus is additional evidence, beyond high inter-annotator agreement, that the quality of the CRAFT corpus is high. The overall poor performance of various systems indicates that considerable work needs to be done to enable natural language processing systems to work well when the input is full-text journal articles. The CRAFT corpus provides a valuable resource to the biomedical natural language processing community for evaluation and training of new models for biomedical full text publications. |
### Instruction:
Does pET-CT accurately predict the pre-operative characteristics of colorectal hepatic metastases?
### Response:
| PET-CT scanning accurately detected the number of lesions and their maximum diameter, with radiological evidence of poorer differentiation. Further studies of non-surgical patients are required to assess its overall accuracy. |
### Instruction:
Do relationship between swim bladder morphology and hearing abilities -- a case study on Asian and African cichlids?
### Response:
| Our results indicate that anterior swim bladder extensions seem to improve mean absolute auditory sensitivities by 21-42 dB (SPLs) and 21-36 dB (PALs) between 0.5 and 1 kHz. Besides anterior extensions, the size of the swim bladder appears to be an important factor for extending the detectable frequency range (up to 3 kHz). |
### Instruction:
Do influence of prophylaxis paste treatment on the abrasive wear of surface sealants?
### Response:
| Stability and wear resistance of surface sealants are not affected by pre-treatment of dentine with NUPRO Sensodyne. The surface sealants tested provide a stable protective surface layer on dentine, which lasts for at least 12 000 brushing strokes. |
### Instruction:
Does overexpression of human SOD1 improve survival of mice susceptible to endotoxic shock?
### Response:
| Aberrant decrease of endogenous SOD1 activities may have overshadowed the effect of overexpression of SOD1 in tg mice (tg-JAX). Mice with C57BL/6J background (tg-TX) are more susceptible to lipopolysaccharide-induced endotoxic shock than those with mixed genetic background (tg-JAX). Overexpression of SOD1 is protective only in mice with C57BL/6J background (tg-TX). |
### Instruction:
Does bromelain limit airway inflammation in an ovalbumin-induced murine model of established asthma?
### Response:
| The results suggest that bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms. |
### Instruction:
Does overexpression of WW domain-containing oxidoreductase WOX1 preferentially induce apoptosis in human glioblastoma cells harboring mutant p53?
### Response:
| Overexpression of WOX1 preferentially inhibited viability and induced apoptosis in human glioblastoma cells expressing mutant p53 via a mechanism independent of the intrinsic apoptotic pathway. Conceivably, the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 and WOX1. This suggests that modulation of WOX1 expression may be a novel strategy for treating human glioblastoma cells with mutant p53. |
### Instruction:
Does mild hypothermia decrease arrhythmia susceptibility in a canine model of global myocardial ischemia*?
### Response:
| Mild hypothermia attenuated ischemia-induced increase in dispersion of repolarization, conduction slowing, and block, which are known mechanisms of arrhythmogenesis in ischemia. These data suggest that therapeutic hypothermia may decrease arrhythmogenesis during myocardial ischemia. |
### Instruction:
Does ventilation with `` clinically relevant '' high tidal volumes promote stretch-induced injury in the lungs of healthy mice?
### Response:
| Tidal volumes up to 20 mL/kg are unlikely to induce substantial lung overstretch in models using healthy, young mice. Signs of injury/inflammation using such models are likely to result from other factors, particularly alveolar derecruitment and atelectasis. The results of such studies may need to be reevaluated before clinical relevance can be accurately determined. |
### Instruction:
Are variants in DENND1A and LHCGR associated with endometrioid adenocarcinoma?
### Response:
| Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. |
### Instruction:
Does chikungunya virus induce a more moderate cytopathic effect in mosquito cells than in mammalian cells?
### Response:
| The reason CHIKV induced strong CPE is that this virus triggers strong apoptosis in Vero cells compared with C6/36 cells. CHIKV established a persistent infection in C6/36 cells after being passaged 20 times. CHIKV infection in mosquito cells was distinct from that in Vero cells. The cell and species specificity of CHIKV-induced cell death implies that the cellular and viral regulators involved in apoptosis may play an important role in determining the outcome of CHIKV infection. |
### Instruction:
Are amino acid substitutions in the hepatitis C Virus core region and lipid metabolism associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy?
### Response:
| Amino acid substitution in the core region of HCV-1b and low serum levels of high-density lipoprotein cholesterol are significant and independent predictors of HCC in nonresponders to IFN+RIB combination therapy. These results emphasize the importance of viral and lipid metabolic factors in the development of HCC after combination therapy. |
### Instruction:
Are peptic ulcer disease and heart disease associated with periprosthetic fractures after total hip replacement?
### Response:
| Peptic ulcer disease and heart disease in primary THR patients and peptic ulcer disease in revision THR patients were associated with higher postoperative periprosthetic fracture risk. Further studies are needed to understand whether disease severity or specific medications used for treatment, or both, are responsible for this association. This may allow identification of modifiable factors. |
### Instruction:
Does the blocking of CXCR3 and CCR5 suppress the infiltration of T lymphocytes in rat renal ischemia reperfusion?
### Response:
| These findings suggest that the blocking of CXCR3 and CCR5 suppress the infiltration of T cells and NKT cells and have a protective effect on kidneys that are injured by I/R. |
### Instruction:
Does intracerebral CpG immunotherapy with carbon nanotubes abrogate growth of subcutaneous melanomas in mice?
### Response:
| These findings suggest that intracerebral CNT-CpG immunotherapy is more effective than systemic therapy in generating antitumor responses that target both brain and systemic melanomas. |
### Instruction:
Does pudendal nerve stretch reduce external urethral sphincter activity in rats?
### Response:
| Acute pudendal nerve stretch produces reversible electrophysiological dysfunction but without leak point pressure impairment. Pudendal nerve stretch shows promise in modeling injury. It should be tested as part of a multi-injury, chronic, physiological model of human childbirth injury. |
### Instruction:
Does targeting androgen receptor lead to suppression of prostate cancer via induction of autophagy?
### Response:
| Findings provide evidence that the androgen receptor might promote prostate cancer cell growth via autophagy down-regulation. Targeting the androgen receptor via ASC-J9 might lead to tumor suppression via the induction of autophagy. This may represent a new, potential therapeutic approach and mechanism for prostate cancer. |
### Instruction:
Does adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protect cortical neurons against excitotoxicity?
### Response:
| Adenosine from glutamate-stressed neurons induces rapid LIF release in astrocytes. This rapid release of LIF promotes the survival of cortical neurons against excitotoxicity. |
### Instruction:
Is the actin binding protein destrin associated with growth and perineural invasion of pancreatic cancer?
### Response:
| Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness. |
### Instruction:
Is invasive pulmonary aspergillosis a frequent complication of critically ill H1N1 patients : a retrospective study?
### Response:
| IPA was diagnosed in 23 % of critically ill patients with H1N1 virus infection after a median of 3 days after ICU admission. Our data suggest that use of CS 7 days before ICU admission is an independent risk factor for fungal superinfection. These findings may have consequences for clinical practice as they point out the need for increased awareness of IPA, especially in those critically ill H1N1 patients already receiving CS. |
### Instruction:
Does functional progressive resistance training improve muscle strength but not walking ability in children with cerebral palsy?
### Response:
| A 12-week functional PRE program improved muscle strength, but did not improve functional walking activity in school-aged ambulatory children with CP. |
### Instruction:
Is the mean apparent diffusion coefficient value ( ADCmean ) on primary cervical cancer a predictive marker for disease recurrence?
### Response:
| The ADCmean of primary cervical cancer calculated by MRI could be an important factor for identifying patients with a risk of disease recurrence. |
### Instruction:
Does cYP7A1 polymorphism influence the LDL cholesterol-lowering response to atorvastatin?
### Response:
| CYP7A1 gene polymorphism influences the LDL-lowering effects of atorvastatin in Chinese Hans. If replicated by others, identification of the tagged functional variant would be needed. |
### Instruction:
Is utilization of intravenous thrombolysis increasing in the United States?
### Response:
| Intravenous recombinant tissue plasminogen activator utilization rates increased between 2001 and 2008. Advanced age and atrial fibrillation were significantly associated with increased morbidity and mortality among patients treated with intravenous recombinant tissue plasminogen activator. |
### Instruction:
Are re-sprains during the first 3 months after initial ankle sprain related to incomplete recovery : an observational study?
### Response:
| A physical examination at 3 months follow-up for the non-recovered ankle sprain patient seems to have no additional value for predicting outcome at 12 months. However, for the non-recovered patients at 3 months follow-up, self-reported pain at rest and re-sprains during the first 3 months of follow-up seem to have a prognostic value for recovery at 12 months. |
### Instruction:
Do dynamic splints reduce contracture following distal radial fracture : a randomised controlled trial?
### Response:
| It is unclear whether dynamic splints following distal radial fracture have therapeutic effects on passive wrist extension or PRHWE, but they clearly do not have any therapeutic effects on active wrist extension, flexion, radial or ulnar deviation, or on the performance or satisfaction items of the COPM. The ongoing use of dynamic splints following distal radial fracture is difficult to justify. |
### Instruction:
Does a 12-week exercise program performed during the second trimester prevent gestational diabetes in healthy pregnant women?
### Response:
| A 12-week exercise program undertaken during the second trimester of pregnancy did not reduce the prevalence of gestational diabetes in pregnant women with BMI in the normal range. |
### Instruction:
Do blood drug concentrations of benzodiazepines correlate poorly with actual driving impairment?
### Response:
| While group mean average ΔSDLP and blood drug concentration sometimes correlate, individual differences in blood drug concentrations of benzodiazepine receptor agonists correlate poorly with driving impairment. From the currently available data, it must be concluded that there are no significant relationships between individual blood drug concentration and ΔSDLP. Future driving studies should assess blood drug levels as a standard procedure, to enable further research into the relationship between blood drug concentration and performance impairment. |
### Instruction:
Does interleukin-15 play an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse?
### Response:
| Our results show that IL-15 is needed for the initial activation of diabetogenic CD8(+) T cells as well as for sustaining the diabetogenic potential of antigen-stimulated cells, acting on both CD8(+) T cells and on APCs. Our findings demonstrate a critical role for IL-15 in the pathogenesis of autoimmune diabetes and suggest that IL-15 is a promising therapeutic target. |
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