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### Instruction:
Do regulatory T cells inhibit CD8 ( + ) T-cell tissue invasion in human skin graft-versus-host reactions?
### Response:
| Preventing effector T-cell tissue invasion is a critical mechanistic event leading to Treg attenuation of GVH tissue damage. This therapeutic effect is associated with a failure of CD8 T cells to increase tissue homing receptors after allo-stimulation, together with a breakdown of interferon-γ-induced chemoattractant expression in the target tissue. |
### Instruction:
Is the TERT variant rs2736100 associated with colorectal cancer risk?
### Response:
| The rs2736100 association demonstrates an influence of variation at 5p15.33 on CRC risk and further evidence that the 5p15.33 (TERT-CLPTM1L) locus has pleiotropic effects (reflecting generic or lineage-specific effects) on cancer risk. |
### Instruction:
Is admission to day stay early parenting program associated with improvements in mental health and infant behaviour : A prospective cohort study?
### Response:
| Tweddle DSPs appear to respond effectively to the needs of families presenting with substantial physical and emotional health morbidity and a range of vulnerabilities by treating parental mental health and infant behaviour problems together. DSPs offer important potential benefits for prevention of more serious family problems and consequent health care cost savings. |
### Instruction:
Does sodium pyruvate reduce hypoxic-ischemic injury to neonatal rat brain?
### Response:
| SP protected neonatal brain from hypoxic-ischemic injury through maintaining cerebral metabolism and mitochondrial function. |
### Instruction:
Is nuclear expression of thioredoxin-1 in the invasion front associated with outcome in patients with gallbladder carcinoma?
### Response:
| TRX-1 nuclear expression in the GBC invasion front is a significant prognostic marker. Patients with both TRX-1 nuclear expression and TRX-R cytoplasmic expression in the tumour invasion front should be observed carefully even if after curative resection. |
### Instruction:
Is population-based analyses of Giardia duodenalis consistent with the clonal assemblage structure?
### Response:
| We conclude that recombination between G. duodenalis assemblages is either very rare or absent. Recombination between genotypes from the same assemblage and genetic exchange between the nuclei of a single cyst needs further investigation. |
### Instruction:
Are mealtime habits and meal provision associated with malnutrition among elderly patients admitted to hospital?
### Response:
| The risk of malnutrition was high among elderly patients admitted to hospital, whereas the proportion with fully developed malnutrition was lower than expected. A long overnight fast, few eating episodes, and not cooking independently were associated with an increased risk of malnutrition. Knowledge of these factors when providing care to the elderly may assist health-care professionals to prevent malnutrition. |
### Instruction:
Does urinary diversion result in marked decreases in proliferation and apoptosis in fetal bladder?
### Response:
| Cell mitotic activity and coordinated cell death appear to be involved in growth and remodeling, which are activated by the mechanical input that occurs during bladder cycling. Fetal urinary diversion results in a repression of mitotic and apoptotic activity, limiting normal bladder growth and remodeling. |
### Instruction:
Does soluble KIT correlate with clinical outcome in patients with metastatic breast cancer treated with sunitinib?
### Response:
| This exploratory analysis suggests that changes in sKIT and possibly VEGF-A early during sunitinib treatment may be predictive of clinical outcome in MBC. |
### Instruction:
Does transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promote non-neurogenic inflammation?
### Response:
| Our results demonstrate that, although either TRPV1 or TRPA1 activation causes airway neurogenic inflammation, solely TRPA1 activation orchestrates an additional inflammatory response which is not neurogenic. This finding suggests that non-neuronal TRPA1 in the airways is functional and potentially capable of contributing to inflammatory airway diseases. |
### Instruction:
Does nupr1-aurora kinase A pathway provide protection against metabolic stress-mediated autophagic-associated cell death?
### Response:
| Our data reveal that Nupr1 is involved in a defense mechanism that promotes pancreatic cancer cell survival when exposed to metabolic stress. |
### Instruction:
Does myocardin-A enhance expression of promyogenic genes without depressing telomerase activity in adipose tissue-derived mesenchymal stem cells?
### Response:
| McA and TERT may interplay in promoting promyogenic gene expression and maintaining growth capacity of MSCs. |
### Instruction:
Does a review of physical activity correlate in patients with bipolar disorder?
### Response:
| The diversity of physical activity measures and subject samples prevented us to perform a meta-analysis. |
### Instruction:
Is uSP22 useful as a novel molecular marker for predicting disease progression and patient prognosis of oral squamous cell carcinoma?
### Response:
| To our knowledge, this is the first study that determines the relationship between USP22 expression and prognosis in OSCC. We found that increased expression of USP22 is associated with poor prognosis in OSCC. USP22 may represent a novel and useful prognostic marker for OSCC. |
### Instruction:
Does estrogen repress hepatocellular carcinoma ( HCC ) growth via inhibiting alternative activation of tumor-associated macrophages ( TAMs )?
### Response:
| Estrogen functions as a suppressor for macrophage alternative activation. |
### Instruction:
Is corky , a gypsy-like retrotransposon differentially transcribed in Quercus suber tissues?
### Response:
| These results document that Corky's transcription levels are not constant. Nevertheless, they depend upon the developmental stage, the tissue analysed and the potential occurring events during an individuals' life span. This modulation brought upon by different developmental and environmental influences suggests an involvement of Corky in stress response and during development. |
### Instruction:
Is n-cadherin differentially expressed in histological subtypes of papillary renal cell carcinoma?
### Response:
| Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future. |
### Instruction:
Does connexin43 gene transfer reduce ventricular tachycardia susceptibility after myocardial infarction?
### Response:
| These data mechanistically link Cx43 expression to slow conduction and arrhythmia susceptibility in the healed scar border zone. Targeted manipulation of Cx43 levels improved conduction velocity and reduced ventricular tachycardia susceptibility. Cx43 gene transfer represents a novel treatment strategy for post-infarction arrhythmias. |
### Instruction:
Does nuclear factor κB activity correlate with the progression and prognosis of pancreatic cancer in a mouse model?
### Response:
| These results suggested that NF-κB activity is related to expression of its downstream target genes, tumor progression and prognosis in experimental pancreatic cancer model. |
### Instruction:
Does precision of usual food intake estimate according to the percentage of individuals with a second dietary measurement?
### Response:
| The precision of the usual intake estimates decreased when low replication rates were used. However, even with different sample sizes, replication rates >40% may not lead to an important loss of precision. |
### Instruction:
Is 11β-hydroxysteroid dehydrogenase type 1 expressed in human sebaceous glands and regulates glucocorticoid-induced lipid synthesis and toll-like receptor 2 expression in SZ95 sebocytes?
### Response:
| Our results indicate that HSD11β1 plays a key role in the modulation of GC action on sebocytes, including sebum production and TLR2-mediated inflammation, thereby influencing the pathogenesis of acne. |
### Instruction:
Does the Val66Met polymorphism of the BDNF gene influence trigeminal pain-related evoked responses?
### Response:
| BDNF Val66Met polymorphism affects the tPREP N2-P2 amplitude decrement and influences cortical pain processing through neurotrophin-induced neural plasticity, or through a direct BDNF neurotransmitter-like effect. Our findings suggest that upcoming BDNF central agonists might in the future play a role in pain management. |
### Instruction:
Are emotion regulation difficulties relevant to persecutory ideation?
### Response:
| Besides the general difficulties in regulating emotion that are common to many clinical disorders and were associated with overall psychopathology, subclinical psychotic symptoms seem to be specifically associated with certain aspects of emotion regulation. Emotion regulation difficulties are likely to contribute to symptom formation and maintenance in persecutory delusions and might therefore present a valuable treatment target. |
### Instruction:
Does loss of Rb cooperate with Ras to drive oncogenic growth in mammalian cells?
### Response:
| We have identified a new role for the Rb family in cell biogenesis and show that, as for other processes associated with tumor development, oncogenic cell growth is dependent on cooperating oncogenes. |
### Instruction:
Do many patients who undergo surgery for colorectal cancer receive surveillance colonoscopies earlier than recommended by guidelines?
### Response:
| Many Medicare enrollees who have undergone curative resection for colorectal cancer undergo surveillance colonoscopy more frequently than recommended by the guidelines. Reducing overuse could free limited resources for appropriate colonoscopy examinations of inadequately screened populations. |
### Instruction:
Does [ Transplantation of autologous myoblasts transfected with VEGF165 improve heart function after myocardial infarction in rabbits ]?
### Response:
| Autologous skeletal myoblasts transfected with VEGF165 could ameliorate the blood supply in the MI region, and aid recovery of heart function more quickly in post-infarction hearts. This suggests an effective treatment for myocardium infarction. |
### Instruction:
Does gOLPH3 overexpression correlate with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer?
### Response:
| Our results suggest GOLPH3 overexpression is associated with poor prognosis for cN0 oral tongue cancer patients and may represent a novel and useful prognostic indicator for cN0 oral tongue cancer. |
### Instruction:
Do protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites?
### Response:
| In addition to demonstrating potentially high levels of TICs in ascites, the results suggest that the S-type population is the less tumorigenic one. Nanog(high)/EpCAM(high) samples represent a TIC subset which may be either M- or S-type, and which is separate from the CD44(high)/Oct-4A(high) subset observed only in M-type samples. This demonstrates a heterogeneity in TIC populations in vivo which has practical implications for TIC isolation based on cell sorting. The biological heterogeneity will need to be addressed in future therapeutical strategies. |
### Instruction:
Do resection of ictal high-frequency oscillations leads to favorable surgical outcome in pediatric epilepsy?
### Response:
| Our study shows that ictal HFOs are commonly found with intracranial EEG in our population largely of children with cortical dysplasia, and have localizing value. The use of ictal HFOs may add more promising information compared to interictal HFOs because of the evidence of ictal propagation and followed by clinical aspect of seizures. Complete resection of HFOs is a favorable prognostic indicator for surgical outcome. |
### Instruction:
Does systemic intermittent parathyroid hormone treatment improve osseointegration of press-fit inserted implants in cancellous bone?
### Response:
| Intermittent treatment with PTH (1-34) improved histological osseointegration of a prosthesis inserted press-fit at surgery in cancellous bone, with no additional improvement of the initial mechanical fixation at this time point. |
### Instruction:
Is asymmetric dimethylarginine strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis?
### Response:
| A strong association of ADMA with cognition and prior HE was found independent of the MELD score in cirrhosis. |
### Instruction:
Is raloxifene hydrochloride an adjuvant antiviral treatment of postmenopausal women with chronic hepatitis C : a randomized trial?
### Response:
| RLX improved the efficacy of SOC in the treatment of postmenopausal women with chronic hepatitis C. RLX shows promise as an adjuvant to the standard antiviral treatment of such patients. |
### Instruction:
Are increased glutathione and mitogen-activated protein kinase phosphorylation involved in the induction of doxorubicin resistance in hepatocellular carcinoma cells?
### Response:
| These findings reveal that the drug resistance could be acquired through mitogen-activated protein kinase-dependent upregulation of P-gp. This mechanism protects R-HepG2 cells from the anticancer action of doxorubicin. |
### Instruction:
Does low digit ratio predict early age at menarche in Colombian schoolgirls?
### Response:
| Digit ratio was positively associated with age at menarche in this longitudinal investigation, consistent with results from a recent gene-linkage study. |
### Instruction:
Does angiotensin II type 1 receptor antagonist prevent hepatic carcinoma in rats with nonalcoholic steatohepatitis?
### Response:
| These data indicated that telmisartan may prevent hepatocarcinogenesis through the inhibition of hepatic angiogenesis even after liver cirrhosis has been established. |
### Instruction:
Does bRCA1 R1699Q variant displaying ambiguous functional abrogation confer intermediate breast and ovarian cancer risk?
### Response:
| Our results provide substantial evidence that the BRCA1 c.5096G>A p.Arg1699Gln (R1699Q) variant, demonstrating ambiguous functional deficiency across multiple assays, is associated with intermediate risk of breast and ovarian cancer, highlighting challenges for risk modelling and clinical management of patients of this and other potential moderate-risk variants. |
### Instruction:
Does a map of human microRNA variation uncover unexpectedly high levels of variability?
### Response:
| Despite an expectation that miRNAs would be highly conserved genomic elements, our study reports a level of variability comparable to that observed for coding genes. |
### Instruction:
Is the expression of tubulin cofactor A ( TBCA ) regulated by a noncoding antisense Tbca RNA during testis maturation?
### Response:
| Our results demonstrate that Tbca13 mRNA levels are post-transcriptionally regulated by the sense and natural antisense Tbca16 mRNA levels. We propose that this regulatory mechanism operates during spermatogenesis, a process that involves microtubule rearrangements, the assembly of specific microtubule structures and requires critical TBCA levels. |
### Instruction:
Does gLUT4 content decrease along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome?
### Response:
| MSG-treated SHR presented all metabolic syndrome characteristics, as well as reduced GLUT4 content, which must play a key role in the impaired glycemic homeostasis of the metabolic syndrome. |
### Instruction:
Does gentamicin affect connexin 26 expression in the cochlear lateral wall?
### Response:
| Connexin 26 plays an important role in the acute effects of high-dose gentamicin and is probably involved in the pathogenesis of ototoxic deafness. |
### Instruction:
Does human pancreatic adenocarcinoma contain a side population resistant to gemcitabine?
### Response:
| We identified a SP in human PDAC and uncovered a chemoresistant and CSC-associated phenotype. This SP may represent a new therapeutic target in pancreatic cancer. |
### Instruction:
Are sex hormone-binding globulin levels causally related to venous thrombosis risk in women not using hormonal contraceptives?
### Response:
| Increased SHBG levels are not causally related to the risk of venous thrombosis. |
### Instruction:
Does evaluation of the osteoconductive potential of bone substitute embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells?
### Response:
| The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation. |
### Instruction:
Do unipolar and bipolar electrogram characteristics predict exit block during pulmonary vein antral isolation?
### Response:
| Specific unipolar and bipolar EGM characteristics are associated with left atrium capture after PV antral isolation. These parameters might be useful in predicting the need for further ablation to achieve exit block. |
### Instruction:
Does insulin aspart have a shorter duration of action than human insulin over a wide dose-range?
### Response:
| IAsp showed a shorter duration of action and, particularly with doses of 12 and 24 (I)U, less late metabolic activity than RHI. These properties might contribute to the lower incidence of hypoglycaemia observed with IAsp versus RHI in clinical trials as lower late metabolic activity should decrease the risk of late postprandial hypoglycaemia. |
### Instruction:
Are polymorphisms in the genes coding for iron binding and transporting proteins associated with disability , severity , and early progression in multiple sclerosis?
### Response:
| Polymorphisms in the genes coding for iron binding and transporting proteins, in the presence of local iron overload, might be responsible for suboptimal iron handling. This might account for the significant variability peculiar to MS phenotypes, particularly affecting MS risk and progression paving the way for personalized pharmacogenetic applications in the clinical practice. |
### Instruction:
Are monitor units predictive of neutron dose for high-energy IMRT?
### Response:
| The predicted increase of second cancer induction rates from intensity-modulated treatment techniques can be overestimated when the neutron dose is simply scaled with monitor units. |
### Instruction:
Are pre-invasive ovarian mucinous tumors characterized by CDKN2A and RAS pathway aberrations?
### Response:
| This study is the largest and highest resolution analysis of mucinous benign and borderline tumors carried out to date and provides strong support for these lesions being precursors of primary ovarian mucinous adenocarcinoma. The high level of uniformity in the molecular events underlying the pathogenesis of mucinous ovarian tumors provides an opportunity for treatments targeting specific mutations and pathways. |
### Instruction:
Do fat mass and obesity-associated gene polymorphisms affect metabolic response to hormone therapy in healthy postmenopausal women?
### Response:
| The presence of fat mass and obesity-associated gene risk variants in healthy early postmenopausal women does not adversely affect their response to hormone therapy. |
### Instruction:
Is high lactate dehydrogenase levels at admission for painful vaso-occlusive crisis associated with severe outcome in adult SCD patients?
### Response:
| Further studies should confirm the predictive value of LDH before its widespread use as a prognostic factor. If it is confirmed, the benefit of preemptive transfusion when LDH levels at admission are very high could be investigated. |
### Instruction:
Is the long leg radiograph a reliable method of assessing alignment when compared to computer-assisted navigation and computer tomography?
### Response:
| Given its availability and reduced radiation dose when compared to CT, LLRs should remain the mainstay of measuring the mechanical alignment of the lower limb, especially post-operatively. |
### Instruction:
Does hip flexion deformity improve without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia?
### Response:
| Our study demonstrates that the hip flexion deformities encountered in these patients will improve spontaneously when the distal fixed knee flexion deformity is surgically corrected. Therefore correction at the knee allows the ground reaction force to assume a more normal position resulting in correction at the hip over time. This then removes the need for surgery at the hip level. This fact is especially important when applied to psoas lengthening as this procedure can cause significant reduction in propulsion power. |
### Instruction:
Is expression of the RET proto-oncogene regulated by TFAP2C in breast cancer independent of the estrogen receptor?
### Response:
| TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. Regulation of Ret by TFAP2C occurs independently of ER expression in breast carcinoma. |
### Instruction:
Do patients with prostate cancer treated by ADT have significantly higher fibrinogenemia than healthy control?
### Response:
| This is the first study that demonstrates the significant increase in FB in PCa patients on ADT, while CRP as inflammatory marker did not increase. Elevation of SF may contribute to increased CVR in PCa patients. Further prospective studies are warranted to confirm this association. |
### Instruction:
Is selective neck dissection effective in N1/N2 nodal stage oral cavity squamous cell carcinoma?
### Response:
| SND may produce a satisfactory ipsilateral regional control rate in patients with early-stage node-positive oral squamous cell carcinoma. A prospective, randomized clinical trial comparing SND with modified radical neck dissection may be required for a categorical conclusion of these findings. |
### Instruction:
Does autophagy limit the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells?
### Response:
| The cytostatic effects of AZ7328 correlate with PIK3CA mutations and are greatly enhanced by dual pathway inhibition using an mTOR inhibitor. Furthermore, AZ7328 can interact with autophagy inhibitors to induce apoptosis in some cell lines. Overall, our results support the further evaluation of combinations of PI3K/AKT/mTOR pathway and autophagy inhibitors in pre-clinical in vivo models and ultimately in patients with PIK3CA mutant bladder cancers. |
### Instruction:
Are racial/ethnic disparities in health-related quality of life and health in children largely mediated by family contextual differences?
### Response:
| Racial/ethnic disparities in children's health status are substantial but may be mediated by corresponding disparities in SES and other family contextual variables. Race/ethnicity and family context are related to one another and should be considered jointly in efforts to reduce health disparities in children. |
### Instruction:
Do risk factors for hypotension in urgently intubated burn patients?
### Response:
| In critically ill burn patients undergoing urgent endotracheal intubation, specific induction agents, including propofol, were not associated with clinically significant hypotension. Presumed sepsis and %TBSA were the most important risk factors. |
### Instruction:
Does magnetoencephalographic imaging of resting-state functional connectivity predict postsurgical neurological outcome in brain gliomas?
### Response:
| Magnetoencephalography connectivity analysis gives a valuable preoperative evaluation of the functionality of the tissue surrounding tumors in perieloquent and eloquent areas. These data may be used to optimize preoperative patient counseling and surgical strategy. |
### Instruction:
Does carbamazepine directly inhibit adipocyte differentiation through activation of the ERK 1/2 pathway?
### Response:
| The effect of CBZ on adipogenesis involves activation of the ERK1/2 pathway. Our results show that CBZ acts directly on pre-adipocytes and adipocytes to alter adipose tissue development and metabolism. |
### Instruction:
Does peroxisome proliferator-activated receptor-δ activation ameliorate albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes?
### Response:
| PPAR-δ activation by GW610742 ameliorates albuminuria by preventing diabetes-induced nephrin loss and restoring podocyte integrity, implying that GW610742 may be a potential therapeutic agent for diabetic nephropathy. |
### Instruction:
Does physician patient communication failure facilitate medication errors in older polymedicated patients with multiple comorbidities?
### Response:
| Mistakes by polymedicated patients with multiple comorbidities represent a real risk that should be addressed by the professionals. A review should be made of the routine control questions that the physician asks the patient to identify what other drugs the patient may be taking that have been indicated by another physician. |
### Instruction:
Is atrial fibrillation associated with severe sleep-disordered breathing in patients with ischaemic stroke and transient ischaemic attack?
### Response:
| Most Japanese patients with acute ischaemic stroke and TIA had SDB, and AF was associated with SDB. |
### Instruction:
Is altered brain-derived neurotrophic factor expression in the ventral tegmental area , but not in the hippocampus , essential for antidepressant-like effects of electroconvulsive therapy?
### Response:
| While neuroplastic alterations, as expressed by changes in BDNF expression within different brain regions, are induced by ECT, the antidepressant-like effect of ECT in an animal model depends on reduction of VTA BDNF expression but not on the elevation of hippocampal BDNF expression. |
### Instruction:
Does chronic social instability induce anxiety and defective social interactions across generations?
### Response:
| These findings support the idea that individual risk for psychiatric disorders that involve enhanced anxiety and/or social dysfunction may be dependent not only on the specific alleles of genes that are inherited from one's parents and on one's own experiences, but also on the experiences of one's parents when they were young. |
### Instruction:
Does preschoolers ' delay of gratification predict their body mass 30 years later?
### Response:
| Longer delay of gratification at age 4 years was associated with a lower BMI 3 decades later. Because this study is correlational, it is not possible to make causal inferences regarding the relationship between delay duration and BMI. Identifying children with greater difficulty in delaying gratification could help detect children at risk of becoming overweight or obese. Interventions that improve self-control in young children have been developed and might reduce children's risk of becoming overweight and also have positive effects on other outcomes important to society. |
### Instruction:
Does gene expression profiling reveal the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome?
### Response:
| Monocytes from CARS patients exhibited significant changes in mRNA expression of genes associated with phagocytosis, antigen presentation, inflammatory response, cell migration, and apoptosis, which might cause deactivation of monocytes during CARS. |
### Instruction:
Is the high glucose-induced stimulation of B1R and B2R expression via CB ( 1 ) R activation involved in rat podocyte apoptosis?
### Response:
| Our study suggests that hyperglycemia induces apoptosis via the stimulation of B1R and B2R expression through CB(1)R activation in rat podocytes in vitro, which is associated with the development of diabetic nephropathy. |
### Instruction:
Is microbial biofilm proliferation within sealer-root dentin interfaces affected by sealer type and aging period?
### Response:
| Within the test model used, the SE and EP sealers were more susceptible to interfacial biofilm proliferation than the TE restorative material. This susceptibility diminished after aging the materials' interfaces for 6 months. |
### Instruction:
Do the correlation between human papillomavirus positivity and abnormal cervical cytology result differs by age among perimenopausal women?
### Response:
| Although the relative proportion of low-grade and high-grade abnormalities did not change with age, we saw a loss of concordance between HR-HPV detection and cytological abnormalities with increasing age. Current guidelines for cervical cancer screening group together all women age 30 years and older. Our data raise important questions about the interpretation of HPV and Pap test results in this age group and suggest that ongoing surveillance of HPV and cytology in cervical cancer screening programs consider a third age stratification among older women. |
### Instruction:
Does probucol ameliorate the development of nonalcoholic steatohepatitis in rats fed high-fat diets?
### Response:
| Probucol shows beneficial effects on HFD-induced steatohepatitis by improving insulin resistance and attenuating oxidative stress and systemic inflammation. |
### Instruction:
Do not all side population cells contain cancer stem-like cells in human gastric cancer cell lines?
### Response:
| SP cells from MKN-45 possess cancer stem cell properties and proved that they were gastric cancer stem-like cells. SP cells from BGC-823 didn't possess cancer stem cell properties and proved that not all SP cells contain cancer stem-like cells in gastric cancer cell lines. |
### Instruction:
Does three-dimensional invasion of human glioblastoma cells remain unchanged by X-ray and carbon ion irradiation in vitro?
### Response:
| These findings indicate that X-rays and carbon ion irradiation effectively reduce proliferation and clonogenic survival without modifying the migration and invasion ability of glioblastoma cells in a collagen type I environment. Addition of targeted agents against members of the MAPK and PI3K signaling axis to conventional chemoradiation therapy seems potentially useful to optimize glioblastoma therapy. |
### Instruction:
Do motion and pain relief remain 23 years after manipulation under anesthesia for frozen shoulder?
### Response:
| In this group of patients treatment of idiopathic frozen shoulder by MUA led to improvement in shoulder motion and function at a mean 23 years after the procedure. |
### Instruction:
Is donor clara cell secretory protein polymorphism a risk factor for bronchiolitis obliterans syndrome after lung transplantation?
### Response:
| Donor CCSP A38G polymorphism is associated with decreased CCSP levels early after lung transplantation and poor long-term outcomes. |
### Instruction:
Do tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival?
### Response:
| TNFRSF25 agonists expand Tregs in vivo and delay allograft rejection. |
### Instruction:
Is disialo-trisialo bridging of transferrin due to increased branching and fucosylation of the carbohydrate moiety?
### Response:
| The di-tri bridging phenomenon was associated with alterations in transferrin glycosylation in the majority of cases. Transferrin contained a higher extent of triantennary and often fucosylated N-linked oligosaccharides. These results may be important in future diagnostic approaches to liver diseases. |
### Instruction:
Does the functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predict improved renal transplant outcome?
### Response:
| Presence of the ficolin-2 Ala258Ser polymorphism in the donor independently predicts improved graft outcome. Based on mechanistic data, we propose that this functional polymorphism leads to more efficient handling of injured cells by phagocytozing cells, resulting in decreased intragraft exposure to danger signals and dampened alloimmune responses. |
### Instruction:
Do kidneys from older living donors provide excellent intermediate-term outcomes after transplantation?
### Response:
| Older living donor kidneys can be transplanted with low perioperative risk without compromising recipient 5-year patient or graft survival or donor renal function. Younger donor kidneys have superior graft function 5 years after transplantation, highlighting the need for appropriate donor/recipient matching. |
### Instruction:
Does combination evaluation of preoperative risk indices predict requirement of biventricular assist device?
### Response:
| The new scoring method, which includes CVP/PCWP ratio, is a novel risk stratification tool for BiVAD therapy. |
### Instruction:
Does fish oil supplementation augment post-exercise immune function in young males?
### Response:
| The current study demonstrates that fish oil supplementation reduces increases PBMC IL-2 production and NK cell cytotoxic activity in the recovery period after exercise. |
### Instruction:
Does submaximal suppression of parathyroid hormone ameliorate calcitriol-induced aortic calcification and remodeling and myocardial fibrosis in uremic rats?
### Response:
| Submaximal suppression of PTH by either CINA or PTX reduced vascular calcifications, arterial remodeling and myocardial fibrosis to a similar degree and independent of the serum calcium and phosphorus levels. These data do not indicate vasculotropic effects of calcimimetics independent of PTH suppression. |
### Instruction:
Does lipopolysaccharide trigger nuclear import of Lpcat1 to regulate inducible gene expression in lung epithelia?
### Response:
| These observations suggest that Lpcat1 relocates into the nucleus in response to bacterial infection to differentially regulate gene transcriptional repression. |
### Instruction:
Does characterization of bovine FUT7 further understanding of FUT7 evolution in mammals?
### Response:
| The FUT7 sequence was highly conserved as well as the specific activity of the encoded protein FucT-VII. In addition, our in silico promoter analysis and the high rate of polymorphism suggested that its function is evolving toward a complex system related to the immune system. Furthermore, comparing bovine to human and mouse sequences, it appeared that a decrease in gene regulation was correlated with an increase in mutation rate and wider tissue expression. |
### Instruction:
Is gNB3 C825T polymorphism associated with postural tachycardia syndrome in children?
### Response:
| The gene polymorphisms GNB3 C825T might be a risk factor for POTS through the enhanced vagal withdrawal of the heart in children and adolescents. |
### Instruction:
Does tumor infiltration in the medial resection margin predict survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma?
### Response:
| The medial surgical resection margin is the most important after PD for PDAC, and an R1 resection here predicts poor survival. |
### Instruction:
Do alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice?
### Response:
| The data reveal that alveolar macrophages and the pattern recognition receptor toll-like receptor-4 are involved in the generation of the early inflammatory response to lung I-R injury. |
### Instruction:
Does bufalin induce the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression?
### Response:
| Bufalin is a potential regimen to be used in combination with conventional chemotherapeutic drugs to improve acute promyelocytic leukemia therapy. |
### Instruction:
Are elevated serum levels of high mobility group box 1 ( HMGB1 ) protein in dengue-infected patients associated with disease symptoms and secondary infection?
### Response:
| We hypothesize that HMGB1 levels correlate with disease pathogenesis, specifically with the clinical symptoms and secondary infection, implicating a pro-inflammatory cytokine role for HMGB1 in DENV infection. This is the first report assessing the circulating levels of HMGB1 during DENV infection. |
### Instruction:
Is basal Ki67 expression measured by digital image analysis optimal for prognostication in oral squamous cell carcinoma?
### Response:
| Our study provides a framework for reaching a consensus on the optimal approach for measuring Ki67 expression in cancers. Our results suggest that rigorous comparisons of measurement approaches should be applied in a tumour-type and treatment-specific manner to enhance the clinical application of Ki67 assessment. |
### Instruction:
Is [ Quality of life an important factor in the indication in patients with advanced pancreatic carcinoma -- a prospective multicentric study ]?
### Response:
| Based on the results of the multicentric prospective study in patients with locally advanced stage III and IV ductal pancreatic adenocarcinoma, the following conclusions can be presented: (1) median and 1, 2 and 3-year survival rates in stage III patients were significantly higher in the RR group compared to the paliative therapy patients, (2) initial QoL in stage III patients was significantly the highest in patients who underwent RR. Significant decrease in QoL was recorded in BDA patients. Paliative stent introduction resulted in nonsignificant improvement in the QoL 3 months after the procedure, while the initial QoL values were the lowest in this group, (3) QoL assessment in stage IV patients showed statistically nonsignificant improvement after BDA or stent procedures, the most significant deterioration was observed in the exploration group, (4) no complication which would result in prolongation of the respective hospitalization times was recorded in 67%, (5) early postoperative complications did not result in significant QoL deterioration 3 months after the procedure, (6) absence of chemotherapy results in significant decrease in QoL. |
### Instruction:
Is ghWRKY15 , a member of the WRKY transcription factor family identified from cotton ( Gossypium hirsutum L. ) , involved in disease resistance and plant development?
### Response:
| Overall, our data suggest that overexpression of GhWRKY15 may contribute to the alteration of defence resistance to both viral and fungal infections, probably through regulating the ROS system via multiple signalling pathways in tobacco. It is intriguing that GhWRKY15 overexpression in tobacco affects plant growth and development, especially stem elongation. This finding suggests that the role of the WRKY proteins in disease resistance may be closely related to their function in regulating plant growth and development. |
### Instruction:
Does olmesartan improve coronary flow reserve of hypertensive patients using coronary magnetic resonance imaging compared with amlodipine?
### Response:
| Olmesartan, but not amlodipine, improves CFR in hypertensive patients. |
### Instruction:
Is end tidal carbon dioxide as reliable as transcutaneous monitoring in ventilated postsurgical neonates?
### Response:
| In postoperative neonates, EtCO2 and TcCO2 demonstrated a clinically acceptable agreement with PaCO2. |
### Instruction:
Does appropriate antibiotic therapy improve Ureaplasma sepsis outcome in the neonatal mouse?
### Response:
| We have established a neonatal model of Ureaplasma sepsis and observed that treatment outcome is related to infecting strain and antibiotic treatment. We speculate that appropriate antibiotic selection and dosing are required for effective treatment of Ureaplasma sepsis in neonates, and this model could be used to further evaluate these relationships. |
### Instruction:
Does high expression of ADAM8 correlate with poor prognosis in hepatocellular carcinoma?
### Response:
| These findings provide evidence that a high expression level of ADAM8 serves as a biomarker for poor prognosis for HCC. Thus, we speculate that ADAM8 may be a potential target of antiangiogenic therapy for HCC. |
### Instruction:
Does exenatide at therapeutic and supratherapeutic concentrations prolong the QTc interval in healthy subjects?
### Response:
| These results demonstrated that exenatide, at supratherapeutic concentrations, does not prolong QTc and provide an example of methodology for QT assessment of drugs with an inherent heart rate effect. |
### Instruction:
Does sigE facilitate the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice?
### Response:
| Much of the work on transcriptional regulation during infection in B. bronchiseptica has focused on the BvgAS two-component system. This study reveals that the SigE regulon also mediates a discrete subset of functions associated with virulence. SigE is the first cell envelope stress-sensing system to be described in the bordetellae. In addition to its role during lethal infection of mice deficient in adaptive immunity, our results indicate that SigE is likely to be important for survival in the face of stresses encountered in the environment between hosts. |
### Instruction:
Is comorbidities remission after Roux-en-Y Gastric Bypass for morbid obesity sustained in a long-term follow-up and correlates with weight regain?
### Response:
| Our results show that comorbidities remission after RYGB is sustained in a long-term follow-up. Weight regain is linked to worse results for all comorbidities except infertility. |
### Instruction:
Is early oral feeding following intestinal anastomoses in children safe?
### Response:
| Early oral feeding following intestinal anastomoses in children is safe, particularly in the setting of limited availability of parenteral nutrition. |
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