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### Instruction:
Does bethanechol activate a post-receptor negative feedback mechanism in rabbit urinary bladder smooth muscle?
### Response:
| Pretreatment of isolated strips of rabbit detrusor with a muscarinic receptor agonist produced short-term down-regulation of KCl-induced peak contractions that may have involved inhibition of both influx of extracellular Ca2+ and release of intracellular Ca2+. Reductions in the degree of this novel modulatory response ... |
### Instruction:
Is hysteroscopic treatment of intrauterine adhesions safe and effective in the restoration of normal menstruation and fertility?
### Response:
| Hysteroscopic adhesiolysis is a safe and effective procedure for restoring the normal menstrual pattern and fertility. The initial severity of the adhesions appears to correlate best with the reproductive outcome. |
### Instruction:
Is argon pneumoperitoneum more dangerous than CO2 pneumoperitoneum during venous gas embolism?
### Response:
| Laparoscopic surgery requires insufflation of gas into the peritoneal cavity. We compared the hemodynamic effects of argon, an inert gas, and carbon dioxide in a pig model of laparoscopic surgery. We conclude that argon carries a high risk factor in the case of an accidental gas embolism. |
### Instruction:
Does prospective analysis of lung-to-head ratio predict survival for patients with prenatally diagnosed congenital diaphragmatic hernia?
### Response:
| The LHR is a useful index to help predict neonatal outcome in patients who have left-sided CDH. |
### Instruction:
Does histone deactylase inhibitor SAHA induce a synergistic HIV-1 reactivation by 12-O-tetradecanoylphorbol-13-acetate in latently infected cells?
### Response:
| These results suggest that the combined approaches of EMAs, cotreatment of SAHA and TPA, could provide an effective way to lead a decline of HIV-1 reservoirs in patients. |
### Instruction:
Are [ Constraints of the dentist consistent with the results of an optimal irradiation with modulated intensity in N0 oropharyngeal cancer ]?
### Response:
| The radiation oncologist can constrain the intensity-modulated radiotherapy dosimetry to the needs of dentists to prevent or improve dental care and quality of life. |
### Instruction:
Is angiotensin II receptor type 2 activation required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain?
### Response:
| Short-term AT2 activation is a potent contributor to thermal hypersensitivity, whereas long-term effects (such as hyperinnervation) also contribute to mechanical hypersensitivity. Pharmacologic blockade of AT2 signaling represents a potential therapeutic strategy aimed at biologic mechanisms underlying chronic inflamma... |
### Instruction:
Is fungal protein MGL_1304 in sweat an allergen for atopic dermatitis patients?
### Response:
| MGL_1304 is a major allergen in human sweat and could cause type I allergy in patients with AD. |
### Instruction:
Is oxysterol-induced apoptosis of smooth muscle cells under the control of a soluble adenylyl cyclase?
### Response:
| These results suggest that the sAC/PKA axis plays a key role in the oxysterol-induced apoptosis of VSMC by controlling mitochondrial Bax translocation and ROS formation and that cytosolic sAC, rather than the mitochondrial pool, is involved in the apoptotic mechanism. |
### Instruction:
Is spinal anesthesia for elective cesarean section associated with shorter hospital stay compared to general anesthesia?
### Response:
| Spinal anesthesia, when compared to general anesthesia shortens postoperative hospital stay with early return of gastrointestinal functions in elective cesarean section. |
### Instruction:
Is acanthamoeba castellanii of the T4 genotype a potential environmental host for Enterobacter aerogenes and Aeromonas hydrophila?
### Response:
| A. hydrophila and E. aerogenes also joined the ranks of other bacteria that could benefit from A. castellanii. Because cysts can be airborne, these findings suggest that Acanthamoeba is a potential vector in the transmission of A. hydrophila and E. aerogenes to susceptible hosts. |
### Instruction:
Is interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment a poor prognostic factor?
### Response:
| Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor. |
### Instruction:
Does homologous recombination mediate cellular resistance and fraction size sensitivity to radiation therapy?
### Response:
| The high fidelity of HR, which is independent of induced DNA damage level, is postulated to explain the low fractionation sensitivity and cellular resistance of cells in S/G2 phase. In conclusion, our results suggest that HR mediates resistance to fractionated radiotherapy, an observation that may help future efforts t... |
### Instruction:
Does vitamin D Deficiency be Prevalent in Morbidly Obese Adolescents Prior to Bariatric Surgery?
### Response:
| Most adolescents presenting for bariatric surgery have suboptimal vitamin D levels, with African Americans and those with higher BMIs at greatest risk for vitamin D deficiency. All morbidly obese adolescents should be screened for vitamin D deficiency before bariatric procedures. |
### Instruction:
Is the preproghrelin 3056 TT genotype associated with the feeling of hunger and low acylated ghrelin levels in Japanese patients with Helicobacter pylori-negative functional dyspepsia?
### Response:
| The preproghrelin 3056TT genotype is significantly associated with the acylated ghrelin levels and the feeling of hunger in H. pylori-negative FD patients. Further studies are needed to clarify the association between the preproghrelin 3056TT genotype and lower plasma acylated ghrelin levels and the impact of this rela... |
### Instruction:
Is human leukocyte antigen-DR mismatch associated with increased in-hospital mortality after a heart transplant?
### Response:
| Human leukocyte antigen-DR mismatch is associated with in-hospital mortality in heart transplant. |
### Instruction:
Does chelidonium majus L. potentiate the hepatic effect of acetaminophen?
### Response:
| C. majus does not modify the hepatic effects of acetaminophen in our in vivo experimental model. |
### Instruction:
Does exercise training reduce peripheral arterial stiffness and myocardial oxygen demand in young prehypertensive subjects?
### Response:
| This study suggests that both resistance and endurance exercise alone effectively reduce peripheral arterial stiffness, central blood pressures, augmentation index, and myocardial oxygen demand in young prehypertensive subjects. |
### Instruction:
Are insulin resistance and the metabolic syndrome associated with arterial stiffness in patients with chronic kidney disease?
### Response:
| IR is independently associated with arterial stiffness, even in nondiabetic CKD. MetS is common and identified a subgroup of CKD patients with increased arterial stiffness, which is associated with dysglycemia. |
### Instruction:
Does implementation of a structured information transfer checklist improve postoperative data transfer after congenital cardiac surgery?
### Response:
| Implementation of an information transfer checklist in postoperative paediatric cardiac surgery patients resulted in a more complete transfer of information, with a decrease in the handover duration. |
### Instruction:
Is p.E66Q mutation in the GLA gene associated with a high risk of cerebral small-vessel occlusion in elderly Japanese males?
### Response:
| GLA p.E66Q mutation is a genetic risk factor for cerebral small-vessel occlusion in elderly Japanese males. |
### Instruction:
Does synergy between the ectoenzymes CD39 and CD73 contribute to adenosinergic immunosuppression in human malignant gliomas?
### Response:
| Our data indicate that glioma-derived CD73 contributes to local adenosine-mediated immunosuppression in synergy with CD39 from infiltrating CD4(+)CD39(+) T lymphocytes, which could become a potential therapeutic target for treatment of malignant glioma and other immunosuppressive diseases. |
### Instruction:
Do the control of phosphate ion release from ion permeable microcapsules formulated into rosin varnish and resin glaze?
### Response:
| Phosphate ion release can be controlled from resin or rosin based dental material by adjusting initial salt solution concentration in microcapsules or percent loading of microcapsules. The potential for burst release from a varnish or slow, sustained release from a sealant has been demonstrated. |
### Instruction:
Does anisomycin suppress Jurkat T cell growth by the cell cycle-regulating proteins?
### Response:
| The results indicate that anisomycin may activate the P53/P21/P27 signaling to decrease the expression of ICBP90, inhibit expression of P-CDK2 to block the cells into S and G2/M phases, and finally result in proliferation inhibition of Jurkat T cells. |
### Instruction:
Are we family -- parents , siblings , and eating disorders in a prospective total-population study of 250,000 Swedish males and females?
### Response:
| The effect of parental education on ED rate varies between males and females, whereas the effect of number of siblings varies according to whether they are full or half-siblings. A deeper understanding of these associations and their underlying mechanisms may provide etiological insights and inform the design of preven... |
### Instruction:
Do the influence of chair seat height on the performance of community-dwelling older adults ' 30-second chair stand test?
### Response:
| Chair seat height's relation to the lower leg length should be considered when interpreting 30-s CST scores. Additionally, it is necessary to optimize the chair seat height when using the 30-s CST as an outcome measure for exercise intervention or to screen for people with weaker lower extremities. |
### Instruction:
Do c-reactive protein and homocysteine predict long-term mortality in young ischemic stroke patients?
### Response:
| There is an independent association between CRP and homocysteine levels obtained several years after ischemic stroke in young adults and subsequent mortality, even when adjusting for traditional risk factors. This association seems to continue for at least 12 years after the measurements. |
### Instruction:
Does dynamic contrast-enhanced MRI in endometrial carcinoma identify patients at increased risk of recurrence?
### Response:
| We demonstrate the feasibility of DCE-MRI in reflecting histological subtype and clinical course in primary endometrial carcinomas. DCE-MRI may potentially provide future biomarkers for preoperative risk stratification in endometrial carcinomas. |
### Instruction:
Does pitavastatin increase HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients?
### Response:
| In addition to its LDL-C-lowering effects, pitavastatin elevates the HDL-C level and enhances the cholesterol efflux capacity and antioxidative properties of HDL. Pitavastatin therefore increases the amount of functional HDL without attenuating HDL quality. |
### Instruction:
Does disruption of Sirt1 in chondrocytes cause accelerated progression of osteoarthritis under mechanical stress and during ageing in mice?
### Response:
| Loss of Sirt1 in chondrocytes led to the accelerated development of OA in mice. Our observations suggest that SIRT1 has a preventive role against the development of OA. |
### Instruction:
Are lymphovascular invasion , ureteral reimplantation and prior history of urothelial carcinoma associated with poor prognosis after partial cystectomy for muscle-invasive bladder cancer with negative pelvic lymph nodes?
### Response:
| Among patients with pelvic lymph node-negative MIBC, PH.UC and UR should be considered as contraindications for partial cystectomy, and LVI is predictive of poor outcomes after partial cystectomy. Highly selective partial cystectomy is a rational alternative to radical cystectomy for the treatment of MIBC with negative... |
### Instruction:
Is vitamin D deficiency in childhood obesity associated with high levels of circulating inflammatory mediators , and low insulin sensitivity?
### Response:
| 25(OH)D deficiency in childhood obesity was associated with enhanced systemic inflammation and reduced insulin sensitivity. The high cathepsin S and sVCAM levels may reflect activation of a pro-inflammatory, pro-diabetic and atherogenic pathway, which could be inhibited by vitamin D supplementation. |
### Instruction:
Are both infected and uninfected mosquitoes attracted toward malaria infected birds?
### Response:
| These results support some, but not all predictions derived from the hypothesis that malaria parasites can manipulate the behaviour of their mosquito vectors to enhance their transmission. The possible mechanisms driving this manipulation, the evolutionary dynamics leading to the modification of the biting behaviour of... |
### Instruction:
Is mean platelet volume decreased in HIV-infected women?
### Response:
| HIV-infected women had lower MPV values than uninfected women, suggesting impaired production rather than increased destruction. Higher than expected cardiovascular event rates cannot be attributed to greater platelet reactivity as measured by MPV. |
### Instruction:
Does sigma-1 receptor knockout impair neurogenesis in dentate gyrus of adult hippocampus via down-regulation of NMDA receptors?
### Response:
| The σ1 R deficiency impairs neurogenesis in DG through down-regulation of NMDArs. |
### Instruction:
Is adipocyte differentiation affected by media height above the cell layer?
### Response:
| Media height during adipogenesis was inversely correlated with lipid content in mature adipocytes. To achieve a high lipid content and greater adipokine secretion, it is best to use a low media volume during differentiation. |
### Instruction:
Does hypo-collagenesis in photoaged skin predict response to anti-aging cosmeceuticals?
### Response:
| Hypo-collagenesis was the only factor that influenced treatment outcome. This study therefore identifies hypo-collagenesis as the unique parameter predicting anti-aging cosmeceutical treatment outcome. These findings provide a basis for future cosmetic testing and the potential development of custom formula skin care. |
### Instruction:
Is the multiple bottle effect overridden in male and female rats by simultaneous presentation of two oral nicotine solutions?
### Response:
| Our findings suggest rats will readily and voluntarily ingest considerably higher doses of nicotine than previously reported resulting in initial systemic cotinine, and trends toward sex differences are mitigated by solution concentration. |
### Instruction:
Do clinical evaluation of salivary periodontal pathogen levels by real-time polymerase chain reaction in patients before dental implant treatment?
### Response:
| The detection levels of the periodontal pathogens targeted in saliva samples were correlated with the periodontal status. This suggests that using saliva to screen for periodontopathic bacteria offers an easier-to-use clinical tool than the paper point method in the diagnosis and treatment of periodontitis and peri-imp... |
### Instruction:
Do dendritic cells play an essential role in transplantation responses via myeloid differentiation factor 88 signaling?
### Response:
| This study provided evidence that DCs play an essential role in alloresponses. |
### Instruction:
Is body weight difference between donor and recipient an important affector of early graft function after renal transplantation?
### Response:
| The index of weight difference/body weight of recipient sensitively and predominantly influenced EGF, which probably reflects the systemic metabolic profile. |
### Instruction:
Are morphological changes in eosinophils reliable markers of the severity of an acute asthma exacerbation in children?
### Response:
| Quantifying the morphological changes in eosinophils is a feasible, easy, and reliable manner to identify the severity of an asthma exacerbation and therefore might improve the clinical management of asthmatic children. |
### Instruction:
Do human umbilical vein endothelial cells synergize osteo/odontogenic differentiation of periodontal ligament stem cells in 3D cell sheets?
### Response:
| This study suggests that the PDLSC-HUVEC co-culture, cell sheet, model exhibits significantly high levels of osteo/odontogenic markers with signs of initial vascular formation. This novel 3D cell sheet-based approach may be potentially beneficial for periodontal regenerative therapy. |
### Instruction:
Does atrial natriuretic peptide reduce hepatic ischemia-reperfusion injury in rabbits?
### Response:
| ANP attenuated hepatic microvascular dysfunction and hepatocyte injury after reperfusion without significant hemodynamic change. |
### Instruction:
Is increase in proteinuria after acute kidney graft rejection associated with decreased graft function and survival?
### Response:
| Increased proteinuria after an acute kidney graft rejection episode was associated with decreased graft function and survival, serving as a surrogate marker for poor outcomes. |
### Instruction:
Does triamcinolone acetonide inhibit p38MAPK activation and neuronal apoptosis in early diabetic retinopathy?
### Response:
| IVTA activates the GR and exerts neural protective effects on retinal neurons. Inhibition of the p38MAPK pathway and activation of GR play a critical anti-apoptotic role in retinal neurons of diabetes following IVTA treatment. Both the anti-inflammatory and anti-apoptotic effects of glucocorticoids may be mediated thro... |
### Instruction:
Is visceral adipose tissue area associated with coronary stenosis and noncalcified plaques?
### Response:
| Excess VAT area was associated with coronary stenosis <50% and noncalcified plaques, independent of traditional cardiovascular risk factors, in an asymptomatic population without a history of coronary artery disease. |
### Instruction:
Do lEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions?
### Response:
| Our results suggest that LEDGINs modulate IN multimerization in progeny virions and impair the formation of regular cores during the maturation step, resulting in a decreased infectivity of the viral particles in the target cells. LEDGINs thus profile as unique antivirals with combined early (integration) and late (IN ... |
### Instruction:
Is eph receptor B4 a regulator of estrogen receptor alpha in breast cancer cells?
### Response:
| Our data suggests EphB4 as an upstream regulator of ER-α in human breast cancer cells by modulating ER-α transcription. The results also suggest Akt as a relevant downstream signaling molecule in this novel EphB4-ER-α pathway. |
### Instruction:
Does aTP-binding cassette B10 regulate early steps of heme synthesis?
### Response:
| ABCB10 plays a critical role in heme synthesis pathway by facilitating δ-aminolevulinic acid production or export from the mitochondria. In contrast to previous reports, we show that ABCB10 is not a heme exporter and instead is required for the early mitochondrial steps of heme biosynthesis. |
### Instruction:
Do phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation?
### Response:
| Phthalates may interfere with immunity against infection and promote the deviation of Th2 response to increase allergy by acting on human pDCs via suppressing IFN-α/IFN-β expression and modulating the ability to stimulate T-cell responses. |
### Instruction:
Is s100A2 a predictive biomarker of adjuvant therapy benefit in pancreatic adenocarcinoma?
### Response:
| S100A2 expression predicts longer DFS and OS in patients treated with adjuvant therapy and should be evaluated as a predictive biomarker. |
### Instruction:
Does single-molecule photobleaching reveal increased MET receptor dimerization upon ligand binding in intact cells?
### Response:
| Our results indicate that partially preformed MET dimers may play a role in ligand binding or MET signaling. The addition of the bacterial ligand internalin B leads to an increase of MET dimers which is in agreement with the model of ligand-induced dimerization of receptor tyrosine kinases. |
### Instruction:
Is periostin downregulation an early marker of inhibited neonatal murine lung alveolar septation?
### Response:
| Postn expression is tightly correlated with the presence of αSMA-myofibroblasts and is a novel early biomarker of acutely inhibited alveolar septation during a crucial window of lung development. |
### Instruction:
Does the value of patient narratives in the assessment of older patients presenting with fall?
### Response:
| Including patient narratives within standard fall-risk assessments could aid in understanding the emotional impact of falls on older patients and how they might respond to interventions. A challenge would be incorporating this within the time restraints of routine clinical practice. |
### Instruction:
Does inosine induce presynaptic inhibition of acetylcholine release by activation of A3 adenosine receptors at the mouse neuromuscular junction?
### Response:
| Our results suggest that, at motor nerve terminals, inosine induces presynaptic inhibition of spontaneous and evoked ACh release by activating A3 receptors through a mechanism that involves L-type and P/Q-type VGCCs and the secretory machinery downstream of calcium influx. A3 receptors appear to be coupled to Gi/o prot... |
### Instruction:
Do forefoot strikers exhibit lower running-induced knee loading than rearfoot strikers?
### Response:
| To our knowledge, this is the first study that shows differences in patellofemoral loading and knee frontal plane moment between FFS and RFS. FFS exhibit both lower patellofemoral stress and knee frontal plane moment than RFS, which may reduce the risk of running-related knee injuries. On the other hand, parallel incre... |
### Instruction:
Is eGFR L2 domain mutation correlated with resistance to cetuximab in metastatic colorectal cancer patients?
### Response:
| Mutation of the EGFR L2 domain was analyzed in mCRC patients. Our findings do not provide sufficient evidence that EGFR L2 domain mutation is correlated with resistance to cetuximab. |
### Instruction:
Are peripheral G protein-coupled inwardly rectifying potassium channels involved in δ-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle?
### Response:
| Our data indicate that peripheral DOR agonist-induced suppression of mechanical hypersensitivity in the masseter muscle involves the activity of peripheral GIRK channels. These results could provide a rationale for developing a novel therapeutic approach using peripheral GIRK channel openers to mimic or supplement the ... |
### Instruction:
Are aDP-induced platelet aggregation and thrombin generation increased in Essential Thrombocythemia and Polycythemia Vera?
### Response:
| ADP-induced platelet aggregation and TG were significantly increased in ET and PV patients compared to controls. The highest values were observed in JAK2V617F positive patients and in patients on aspirin. In these subjects, annexin V was less effective in inhibiting both basal and ADP-induced TG. This study demonstrate... |
### Instruction:
Is perioperative allogenenic blood transfusion associated with worse clinical outcomes for hepatocellular carcinoma : a meta-analysis?
### Response:
| The findings from the current meta-analysis demonstrated that ABT was associated with adverse clinical outcomes for HCC patients undergoing surgery, including increased death, recurrence and complications. Therefore, ABT should not be performed if possible. |
### Instruction:
Is chronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus?
### Response:
| The results suggest that scopolamine-induced cognitive deficits on RDIL are related to the distinguishing alteration of CREB signaling in the DH and CCx. |
### Instruction:
Does obesity accelerate Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response?
### Response:
| Here, we have established a model to study the molecular mechanism by which obesity predisposes individuals to gastric cancer. In H felis-infected mice, obesity increased proinflammatory immune responses and accelerated gastric carcinogenesis. Interestingly, gastric inflammation augmented obesity-induced adipose inflam... |
### Instruction:
Is the preferential selection of K65R in HIV-1 subtype C attenuated by nucleotide polymorphisms at thymidine analogue mutation sites?
### Response:
| These results further demonstrate that stavudine can preferentially select for K65R in subtype C virus and also provide a basis for understanding the importance of silent nucleotide polymorphisms in regard to altered HIV drug resistance profiles. |
### Instruction:
Is amyloid-β peptide-induced extracellular S100A9 depletion associated with decrease of antimicrobial peptide activity in human THP-1 monocytes?
### Response:
| Collectively, our findings suggest that the mostly monomeric form of Aβ1-42 negatively regulates the innate immune system by down-regulating the secretion of S100A9, which is likely a main mediator of antimicrobial activity in the conditioned media of human THP-1 monocytes. |
### Instruction:
Does β-Receptor blocker influence return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation?
### Response:
| Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during CPR. An increasing high blood K(+) value would attenuate the rate of a successful CPR. |
### Instruction:
Does down-regulation of eIF5A-2 prevent epithelial-mesenchymal transition in non-small-cell lung cancer cells?
### Response:
| The expression of eIF5A-2 was up-regulated following EMT phenotype changes in A549 cells, which correlated with enhanced tumor invasion and metastatic capabilities. Furthermore, in the A549 cell line, the process of EMT phenotype change could be reversed by eIF5A-2 siRNA, with a consequent weakening of both invasive an... |
### Instruction:
Is dietary glycemic index during pregnancy associated with biomarkers of the metabolic syndrome in offspring at age 20 years?
### Response:
| Our data suggests that high dietary GI in pregnancy may affect levels of markers for the metabolic syndrome in young adult offspring in a potentially harmful direction. |
### Instruction:
Do colony forming unit endothelial cells exhibit telomerase alternative splicing variants and activity?
### Response:
| The absence of telomerase activity in the CFU-EC is a result of pre-transcriptional regulation of gene expression rather than other mechanisms for controlling telomerase activity such as post-transcriptional modifications. This finding can explain the limited proliferative activity of CFU-EC cells. We propose that abse... |
### Instruction:
Does transplanting p75-suppressed bone marrow stromal cells promote functional behavior in a rat model of spinal cord injury?
### Response:
| Our data suggest that genetically modified BMSC that express p75:siRNA could be a more suitable source of cells for treatment of SCI. |
### Instruction:
Do small-bore chest tubes seem to perform better than larger tubes in treatment of spontaneous pneumothorax?
### Response:
| We found small chest tubes to be superior to large-bore chest tubes with regard to short-term outcomes in the treatment of non-traumatic PT. |
### Instruction:
Is pseudomonas aeruginosa in patients without cystic fibrosis strongly associated with chronic obstructive lung disease?
### Response:
| P. aeruginosa is an opportunistic bacterium infecting primarily patients with severe lung disease. Our data show a significant reduction in lung function among P. aeruginosa-positive non-CF patients over a three-year period of time. The reduction, however, is not different than otherwise reported in COPD patients in ge... |
### Instruction:
Is the content of macronutrients in milk from mothers of very preterm infants highly variable?
### Response:
| Protein content in human milk varies considerably between mothers, and decreases within weeks after very preterm birth. Previous breastfeeding experience and low GA were associated with a lower protein and a higher fat and energy content in HM, respectively. Inter-individual differences in human milk content possibly i... |
### Instruction:
Does nitrous oxide provide safe and effective analgesia for minor paediatric procedures -- a systematic review?
### Response:
| Nitrous oxide is a safe and effective method to achieve analgesia and sedation during minor, but painful procedures. It can be safely administered by a dedicated staff member. This helpful method is still underused in Denmark, and we believe that it could be an alternative or the first choice of treatment in emergency ... |
### Instruction:
Is significant increase in hEGF uptake correlated with formation of EGFR dimers induced by the EGFR tyrosine kinase inhibitor gefitinib?
### Response:
| These results suggest that hEGF could enhance EGFR-targeting when used with gefitinib. |
### Instruction:
Does beta2-adrenoceptor stimulation suppress TLR9-dependent IFNA1 secretion in human peripheral blood mononuclear cells?
### Response:
| We provide insights into the underlying mechanisms of the interrelation between immune responses and pharmacological agents widely used in clinical practice. Our results have implications for the future treatment of human patients, in which the endogenous immune response plays a pivotal role, such as during viral infec... |
### Instruction:
Does surgery improve breast cancer-specific survival in octogenarians with early-stage breast cancer?
### Response:
| In women ≥80 years with early-stage breast cancer, standard surgical treatment as compared with non-surgical therapy was associated with a better breast cancer-specific. |
### Instruction:
Does correction of hyperphosphatemia suppress cardiac remodeling in uremic rats?
### Response:
| These results suggest that correction of hyperphosphatemia by lanthanum carbonate could suppress cardiac remodeling independently of changes in FGF23. |
### Instruction:
Is helicobacter pylori infection positively associated with gallstones : a large-scale cross-sectional study in Japan?
### Response:
| HP infection is positively associated with gallstones. HP eradication may lead to prevention of gallstones. |
### Instruction:
Does intrauterine insemination ( IUI ) improve pregnancy rates in infertile couples where semen parameters are normal and postcoital tests are adequate?
### Response:
| There is no evidence to support the notion that IUI improves pregnancy rates in circumstances where the semen analysis and postcoital tests are normal. |
### Instruction:
Does very low cerebral blood volume predict parenchymal hematoma in acute ischemic stroke?
### Response:
| Very low CBV was the only independent predictor of PH in patients with acute stroke. |
### Instruction:
Do stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size?
### Response:
| Antibodies that bind recombinant GluN1-S2 peptides (but not the intact GluN1 protein) develop transiently in patients after stroke in proportion to infarct size, suggesting that these antibodies are raised secondarily to neuronal damage. The anti-GluN1-S2 antibodies may provide useful information about the presence and... |
### Instruction:
Is abdominal aortic calcification superior over other vascular calcification in predicting mortality in hemodialysis patients : a retrospective observational study?
### Response:
| VC in different arteries as shown on radiographs is associated with different levels of risk for mortality. The lateral abdominal radiograph may not be superior to other radiographs for predicting patient outcomes. Further research is needed to elucidate the effects of difference burdens of VC on patient outcomes. |
### Instruction:
Do supratherapeutic vancomycin levels after trauma predict acute kidney injury and mortality?
### Response:
| AKI is common in trauma patients who receive intravenous vancomycin. A supratherapeutic trough level of >20 mg/L is an independent predictor of AKI and mortality in trauma patients. |
### Instruction:
Is the drug efflux pump Pgp1 in pro-inflammatory lymphocytes a target for novel treatment strategies in COPD?
### Response:
| Treatment strategies that target Pgp1 in T, NKT-like and NK cells may reduce systemic inflammatory mediators in COPD and improve patient morbidity. |
### Instruction:
Are higher doses of erythropoietin-stimulating agents and hyporesponsiveness to their effects associated with increased mortality among prevalent hemodialysis patients?
### Response:
| Among prevalent hemodialysis patients, a higher degree of resistance to and higher doses of ESA are associated with increased mortality. |
### Instruction:
Is the mitogen-inducible gene-6 involved in regulation of cellular senescence in normal diploid fibroblasts?
### Response:
| Mig-6 induces premature senescence via functioning in regulation of cellular senescence in normal diploid fibroblasts. |
### Instruction:
Is obstructive sleep apnea associated with fatty liver and abnormal liver enzymes : a meta-analysis?
### Response:
| Routine assessment of liver enzymes and liver damage should be implemented in OSA patients because they have an increase of 13.3% of ALT and 4.4% of AST levels, and a 2.6-fold higher risk of liver fibrosis when they have NAFLD, which is 2.6 times more frequent in OSA patients. |
### Instruction:
Does preemptive therapy prevent cytomegalovirus end-organ disease in treatment-naïve patients with advanced HIV-1 infection in the HAART era?
### Response:
| The results indicate that preemptive therapy lowers the incidence of CMV-EOD by almost 25%. Preemptive therapy for treatment-naïve patients with CMV viremia is effective, although monitoring of potential treatment-related side effects is required. |
### Instruction:
Does rapid on-site pathologic evaluation increase the efficacy of endobronchial ultrasonographic biopsy for mediastinal staging?
### Response:
| ROSE does not impact clinical decision making if a thorough mediastinal staging using EBUS is performed. Despite inadequate tissue sampling assessment by ROSE, a final diagnosis was made in most patients, potentially avoiding an additional surgical procedure to prove mediastinal disease. |
### Instruction:
Does synchrotron microbeam radiation therapy induce hypoxia in intracerebral gliosarcoma but not in the normal brain?
### Response:
| We provide new evidence for the differential effect of MRT on tumor vasculature, an effect that leads to tumor hypoxia. As hypothesized formerly, the vasculature of the normal brain exposed to MRT remains sufficiently perfused to prevent any hypoxia. |
### Instruction:
Is the standardised mortality ratio unreliable for assessing quality of care in rectal cancer?
### Response:
| The increased SMR appeared to be caused by the admission of patients who received palliative care only. Consequently, the SMR is unreliable for the assessment of quality of care in patients with rectal or anal cancer. |
### Instruction:
Does deficiency of senescence marker protein 30 exacerbate angiotensin II-induced cardiac remodelling?
### Response:
| This study demonstrated the first evidence that deficiency of SMP30 exacerbates Ang II-induced cardiac hypertrophy, dysfunction, and remodelling, suggesting that SMP30 has a cardio-protective role in cardiac remodelling with anti-oxidative and anti-apoptotic effects in response to Ang II. |
### Instruction:
Are women with symptoms of uncomplicated urinary tract infection often willing to delay antibiotic treatment : a prospective cohort study?
### Response:
| More than a third of women with UTI symptoms are willing to delay antibiotic treatment when asked by their GP. The majority of delaying women report spontaneous symptom improvement after one week. |
### Instruction:
Is chitotriosidase a biomarker for the resistance to World Trade Center lung injury in New York City firefighters?
### Response:
| Increased serum chitotriosidase reduces the odds of developing obstruction after WTC-particulate matter exposure and is associated with recovery of lung function. Alternately, elevated IgE is a risk factor for airflow obstruction and progressive lung function decline. |
### Instruction:
Is bone plasticity in response to exercise sex-dependent in rats?
### Response:
| Exercise yielded differential adaptations with respect to bone structure, biomechanical proprieties, and molecular signaling in male and female rats. |
### Instruction:
Does endophytic Penicillium funiculosum LHL06 secrete gibberellin that reprograms Glycine max L. growth during copper stress?
### Response:
| The endophyte P. funiculosum symbiosis counteracted the Cu stress and reprogrammed soybean plant growth. Such growth promoting and stress mediating endophytes can be applied at field levels to help in bioremediation of the polluted agricultural fields. |
### Instruction:
Does tumor suppressor gene RBM5 delivered by attenuated Salmonella inhibit lung adenocarcinoma through diverse apoptotic signaling pathways?
### Response:
| In this study, we established a novel animal model to determine RBM5 function in vivo, and concluded that RBM5 inhibited tumor growth in mice by inducing apoptosis. The study suggests that although RBM5's involvement in the death receptor-mediated apoptotic pathway is still to be investigated, RBM5-mediated growth supp... |
### Instruction:
Is profibrotic interleukin-33 correlated with uterine leiomyoma tumour burden?
### Response:
| Serum IL-33 is elevated in women with uterine leiomyoma and correlated with features of uterine leiomyoma tumour burden, namely fibroid number, size and weight. |
### Instruction:
Does homeostatic generation of reactive oxygen species protect the zebrafish liver from steatosis?
### Response:
| De novo GMP synthesis influences the activation of the small GTPase Rac1, which controls hepatic lipid dynamics through ROS-mediated regulation of triglyceride hydrolase expression in hepatocytes. |
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