question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Is silence golden : effect of encouragement in motivating the weak link in an online exercise video game?
### Response:
| Exercising conjunctively with an Internet partner can boost one's duration of exercise. However, encouragement from the stronger to the weaker member can mitigate these gains, especially if one perceives such comments being directed at someone other than themselves. To boost exercise duration, Internet-based physical a... |
### Instruction:
Do surveillance neuroimaging and neurologic examinations affect care for intracerebral hemorrhage?
### Response:
| More than 25% of surgical interventions performed after ICH were prompted by delayed imaging or clinical findings. Serial neurologic examinations and neuroimaging are important and effective surveillance techniques for monitoring patients with ICH. |
### Instruction:
Does a corn oil-based diet protect against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis?
### Response:
| A CO-based diet is protective against combined EtOH- and iron-induced liver toxicity, likely via attenuation of hepatic steatosis and oxidative stress and may have a role in the prevention of fibrosis development in chronic liver disease. |
### Instruction:
Is poverty the main environmental factor for obesity in a Mexican-border city?
### Response:
| Residence in a low-income neighborhood was a predictor for obesity. |
### Instruction:
Do obese subjects have significantly higher serum prooxidantantioxidant balance values compared to normal-weight subjects?
### Response:
| The high levels of PAB values in obese subjects without overt signs/symptoms of cardiovascular disease may be related to a heightened state of oxidative stress associated with obesity. |
### Instruction:
Are treatment goals for ambulatory blood pressure and plasma lipids after stroke often not reached?
### Response:
| For blood pressure (BP) and cholesterol, secondary prevention is far from ideal in post-stroke patients. Compared with OBP, ABP demands more resources, but in turn yields more reliable results and also provides important information about diurnal BP variation. ABP monitoring at least once after stroke should therefore ... |
### Instruction:
Does necrostatin-1 inhibit the degeneration of neural cells induced by aluminum exposure?
### Response:
| The present study provides the first direct evidence of a connection between necroptosis and neurodegeneration, which indicates that necroptosis is involved in neurodegenerative cell death. Furthermore, Nec-1 may be useful for the prevention and treatment of neurodegenerative disorders. |
### Instruction:
Does vascular angiotensin II type 2 receptor attenuate atherosclerosis via a kinin/NO-dependent mechanism?
### Response:
| Vascular AT2 stimulation exerts anti-atherogenic actions in an endothelial kinin/NO-dependent manner, and its anti-oxidative effect is likely to be exerted by inhibiting the accumulation of superoxide-producing mononuclear leukocytes. |
### Instruction:
Does standardized laparoscopic simulation positively affect a student 's surgical experience?
### Response:
| Our results demonstrate how a standardized orientation to basic laparoscopy can make a positive effect on a student's experience; however, it fails to transition into a student's interest in surgery as a profession or in their perceived comfort level in the operating room. Our study suggests that a student's surgical i... |
### Instruction:
Does interleukin-6 prevent NMDA-induced neuronal Ca2+ overload via suppression of IP3 receptors?
### Response:
| The present results suggest that IL-6 suppresses NMDA-induced neuronal Ca(2+) overload by inhibiting NMDAR and IP3R activities. |
### Instruction:
Does [ Assessment of patient need to design a patient education program in systemic lupus erythematosus ]?
### Response:
| The direct consultation of patients with SLE targeted by a specific PEP program allowed us to confirm and adapt the topics and the content of a program designed by medical staff. |
### Instruction:
Does a standardized assessment of thyroid nodules in children confirm higher cancer prevalence than in adults?
### Response:
| Neck ultrasonography and biopsy were key to the evaluation of children with suspected thyroid nodules. Although the relative cancer prevalence of sonographically confirmed nodules ≥ 1 cm is higher in pediatric patients than adults, most children referred for suspected nodules have benign conditions, and efforts to avoi... |
### Instruction:
Is cyclin D1-induced proliferation independent of beta-catenin in head and neck cancer?
### Response:
| Taken together, we show that the change in cyclin D1 levels is more likely to be due to the EGFR-Akt pathway activation than due to beta-catenin nuclear translocation. |
### Instruction:
Does cRYAB modulate the activation of CD4+ T cells from relapsing-remitting multiple sclerosis patients?
### Response:
| CRYAB may be capable of suppressing the activation of CD4(+) T cells from a subset of RRMS patients who appear to have less disability but similar age and disease duration. |
### Instruction:
Does use of impedance threshold device in conjunction with our novel adhesive glove device for ACD-CPR result in additional chest decompression?
### Response:
| Active compression decompression delivered by this simple and inexpensive adhesive glove device resulted in improved cerebral blood flow and coronary perfusion pressure. There was no statistically significant added effect of ITD use along with AGD-CPR on the decompression of the chest. |
### Instruction:
Do diesel exhaust particles selectively induce both proinflammatory cytokines and mucin production in cornea and conjunctiva human cell lines?
### Response:
| These findings suggest that human corneal and conjunctival epithelial cells incubated with DEP showed cytotoxicity and an inflammatory response mediated by IL-6, not by TNF-α or IL-8. Also, the decrease in mucin expression in the cornea cells might leave exposed areas in the cornea for contact with DEP. Finally, the in... |
### Instruction:
Is atorvastatin therapy associated with slowing the progression of aortic stenosis : findings of a randomized controlled trial?
### Response:
| The findings of the present randomized trial did not support a beneficial effect of statin therapy (20 mg/day) against AS progression in Iranian patients with mild to moderate disease. |
### Instruction:
Is high-sensitivity C-reactive protein a predictive factor of adiposity in children : results of the identification and prevention of dietary- and lifestyle-induced health effects in children and infants ( IDEFICS ) study?
### Response:
| Higher hs-CRP levels are associated to higher body mass and overweight/obesity risk in a large population of European children. Children with higher baseline levels of hs-CRP had a greater increase in BMI z-score and central adiposity over time and were at higher risk of developing overweight/obesity during growth. |
### Instruction:
Is early incidence of occupational asthma accelerated by atopy in the bakery/pastry and hairdressing sectors?
### Response:
| OA symptoms occur soon after the start of exposure. Our results suggest that atopy does not precipitate the occurrence of symptoms in two different allergen exposure settings. |
### Instruction:
Does 5-Lipoxygenase play a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1?
### Response:
| 5-LO expression in monocytes is modulated via NF-κB and Sp1 signalling pathways, and 5-LO plays a pivotal role in LPS-mediated monocyte adhesion to the vascular endothelium through an increased expression of Mac-1 on monocytes. |
### Instruction:
Does loss of function of C9orf72 cause motor deficits in a zebrafish model of amyotrophic lateral sclerosis?
### Response:
| Our results indicate C9orf72 haploinsufficiency could be a contributing factor in the spectrum of ALS/FTLD neurodegenerative disorders. Loss of function of the zebrafish orthologue of zC9orf72 expression in zebrafish is associated with axonal degeneration of motor neurons that can be rescued by expressing human C9orf72... |
### Instruction:
Are tRPA1 and TRPV1 differentially involved in heat nociception of mice?
### Response:
| Our results indicate that in addition to TRPV1, TRPA1 plays a role in heat nociception, in particular in definition of the heat threshold, and might therefore serve as a therapeutic target in acute inflammatory pain. |
### Instruction:
Is beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells lost by inhibiting vascular endothelial growth factor?
### Response:
| The beneficial effects of mechanical stimulation on MDSC-mediated muscle repair are lost by inhibiting VEGF. |
### Instruction:
Does hSPA12B attenuate cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism?
### Response:
| These data demonstrate for the first time that the overexpression of HSPA12B attenuates cardiac dysfunction and remodelling after MI. This action of HSPA12B was mediated, at least in part, by prevention of cardiomyocyte apoptosis and promotion of myocardial angiogenesis via an eNOS-dependent mechanism. HSPA12B could be... |
### Instruction:
Is in children with premature adrenarche , bone age advancement by 2 or more years common and generally benign?
### Response:
| Very advanced BA is common in PA, and patients were significantly taller and more overweight than their peers. The impact of advanced BA on PAH appears to be minor. We question the need for ordering a BA in patients with PA, and suggest that extensive testing is unnecessary simply because of advanced BA. |
### Instruction:
Does axis I and Axis II diagnose in women with PCOS?
### Response:
| Our results suggest that a considerable proportion of women with PCOS also present with anxiety and personality disorders. |
### Instruction:
Is glycogen phosphorylase isoenzyme BB plasma kinetics related to myocardial ischemia induced by exercise stress echo test?
### Response:
| GPBB plasma concentration increases after ESET, and it is not related to inducible myocardial ischemia. However, it seems that GPBB release during ESET might be related to exercise load/duration. |
### Instruction:
Does vitamin E protect chondrocytes against hydrogen peroxide-induced oxidative stress in vitro?
### Response:
| Vitamin E reversed the oxidant-induced alterations in chondrocytes and may be a good option to pretreat chondrocytes before transplantation. |
### Instruction:
Is hypertensive disease of pregnancy associated with decreased risk for respiratory distress syndrome in moderate preterm neonates?
### Response:
| HDP is associated with a lower risk of developing RDS in moderate preterm neonates. This could have clinical implications in terms of risk stratification for this group of neonates. |
### Instruction:
Does neurotrophin-3 stimulate migration of mesenchymal stem cells overexpressing TrkC?
### Response:
| The present results suggest that NT-3 may play a role in attracting MSCs with its high affinity for TrkC as a chemokine receptor. |
### Instruction:
Do ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts?
### Response:
| These results show that a ketogenic diet enhances radio-chemo-therapy responses in lung cancer xenografts by a mechanism that may involve increased oxidative stress. |
### Instruction:
Is claudin 1 expression in basal-like breast cancer related to patient age?
### Response:
| The association of high claudin 1 protein levels observed in tumors derived from older women with BLBC, suggests that claudin 1 has the potential to serve as a marker which can identify a specific subgroup of patients within the BLBC subtype and thus, further contribute to the characterization of these ill-defined brea... |
### Instruction:
Does isoflurane in contrast to propofol promote fluid extravasation during cardiopulmonary bypass in pigs?
### Response:
| During CPB, isoflurane, in contrast to propofol, significantly contributes to a general increase in fluid shifts from the intravascular to the interstitial space with edema formation and a possible negative impact on postoperative organ function. |
### Instruction:
Does lacrimal gland uptake of ( 67 ) Ga-gallium citrate correlate with biopsy results in patients with suspected sarcoidosis?
### Response:
| Lacrimal biopsy positivity rate significantly correlated with gallium uptake on scintigraphy. Both SVS and LUR methods appear to correlate with histologic results and may potentially aid in patient selection for biopsy. |
### Instruction:
Does hydrogen sulfide inhibit abnormal proliferation of lymphocytes via AKT/GSK3β signal pathway in systemic lupus erythematosus patients?
### Response:
| These results demonstrate that H2S inhibits the abnormal activation of lymphocytes from SLE patients throuqh the AKT/GSK3β signal pathway. |
### Instruction:
Do comorbid alcohol and cannabis use disorders among high-risk youth at intake into residential care?
### Response:
| Many more common than specific correlates were identified; these variables may be associated with generalized risk for substance use disorders. Two variables were particularly strong positive correlates of comorbid AUD and CUD, and potentially could be targeted in interventions designed to prevent comorbid substance us... |
### Instruction:
Does a self-defense program reduce the incidence of sexual assault in Kenyan adolescent girls?
### Response:
| A standardized 6-week self-defense program is effective in reducing the incidence of sexual assault in slum-dwelling high school girls in Nairobi, Kenya. |
### Instruction:
Does lipoxin A4 attenuate acute rejection via shifting TH1/TH2 cytokine balance in rat liver transplantation?
### Response:
| LXA4 attenuated acute rejection with a parallel shift from Th1 to Th2 responses in rat liver transplantation. |
### Instruction:
Is ephA4 a prognostic factor in gastric cancer?
### Response:
| EphA4 may play important roles in tumor progression and outcomes in patients with gastric cancer. |
### Instruction:
Does sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor require E-cadherin in esophageal cancer and malignant pleural mesothelioma?
### Response:
| E-Cadherin expression appears to be not only a strong biomarker but also a functional requirement and potential therapeutic target for sensitivity to EGFR-TKI. |
### Instruction:
Is parathyroid hormone significantly associated with body fat compartment in men but not in women following a hip fracture?
### Response:
| PTH serum levels were robustly associated with body fat compartment in men, but not in women following a fracture of the hip. A role of PTH in affecting body composition in hip fracture men is suggested. Its potential role in male prognostic disadvantage needs further investigation. |
### Instruction:
Is uSP8 a novel target for overcoming gefitinib resistance in lung cancer?
### Response:
| Our results show for the first time that the inhibition of USP8 activity or reduction in USP8 expression can selectively kill NSCLC cells. We propose USP8 as a potential therapeutic target for gefitinib-resistant and -sensitive NSCLC cells. |
### Instruction:
Are neural mechanisms of attention-deficit/hyperactivity disorder symptoms stratified by MAOA genotype?
### Response:
| Depending on MAOA genotype, ADHD symptoms in adolescent boys are associated with either reward deficiency or insufficient response inhibition. Apart from its mechanistic interest, our finding may aid in developing pharmacogenetic markers for ADHD. |
### Instruction:
Do posterior buttress plate with locking compression plate for Hoffa fracture?
### Response:
| Improved stability associated with this technique enables patients to begin range-of-motion training and return to their normal activities sooner; this resulted in good outcome. |
### Instruction:
Is high myeloperoxidase positive cell infiltration in colorectal cancer an independent favorable prognostic factor?
### Response:
| High density MPO+ cell infiltration is a novel independent favorable prognostic factor in CRC. |
### Instruction:
Does fGF23 modify the relationship between vitamin D and cardiac remodeling?
### Response:
| We identified significant interactions among 25(OH)D, 1,25(OH)2D, and FGF23 on cardiac remodeling. Increased LV mass and cavity dilatation were observed with low 25(OH)D and high FGF23. Our findings suggest that consideration of both hormones is crucial to understanding the role of either in cardiac remodeling, and may... |
### Instruction:
Is treatment with beta-blockers associated with lower levels of Lp-PLA2 and suPAR in carotid plaques?
### Response:
| The reduced levels of Lp-PLA2 and suPAR in human carotid plaques of subjects on long-term treatment with beta-blockers suggest their possible protective role in plaque inflammation. Our findings support an even more selective Lp-PLA2 and suPAR inhibition as a possible strategy for the prevention of cardiovascular disea... |
### Instruction:
Does overexpression of Smad2 inhibit proliferation of gingival epithelial cells?
### Response:
| The signaling activation triggered by overexpression of Smad2 was dependent on TGF-β type I receptor, and the activated Smad2 increased p15 and p21 expression, responsible for inhibiting cell cycle entry, resulting in antiproliferative effects on gingival epithelial cells. Understanding of Smad2-induced signaling would... |
### Instruction:
Does biofilm medium lead to apatite formation on bioactive surfaces?
### Response:
| The use of BM is a promising method for studies involving simultaneous biofilm growth and apatite formation on bioactive surfaces. |
### Instruction:
Does repeated thermo-sterilisation further affect the reliability of positive end-expiratory pressure valves?
### Response:
| The reliability of PEEP valves is affected by repeated TS. Multi-use PEEP valves should be tested for reliable PEEP provision following TS. |
### Instruction:
Is plasma vitamin C , but not vitamin E , associated with reduced risk of heart failure in older men?
### Response:
| Higher plasma vitamin C is associated with a reduced risk of HF in older men with and without myocardial infarction. High intake of dietary vitamin E may be associated with increased HF risk. Primary intervention trials assessing the effect of vitamin C supplements on HF risk in the elderly are needed. |
### Instruction:
Are negative aspects of close relationships more strongly associated than supportive personal relationships with illness burden of irritable bowel syndrome?
### Response:
| Different aspects of social relationships - support and negative interactions - are associated with multiple aspects of IBS experience (e.g. stress, QOL impairment). Negative social relationships marked by conflict and adverse exchanges are more consistently and strongly related to IBS outcomes than social support. |
### Instruction:
Are variants in PPP3R1 and MAPT associated with more rapid functional decline in Alzheimer 's disease : the Cache County Dementia Progression Study?
### Response:
| We replicate a previous report by Cruchaga et al that specific variations in rs3785883 and rs1868402 are associated with accelerated progression of AD. Further characterization of this association will provide a better understanding of how genetic factors influence the rate of progression of AD and could provide novel ... |
### Instruction:
Does aTP interact with the CPVT mutation-associated central domain of the cardiac ryanodine receptor?
### Response:
| The RyR2 central domain, expressed as a 'correctly' folded recombinant protein, bound ATP in accord with bioinformatics evidence of conserved ATP binding sequence motifs. An interaction with FKBP12.6 was not evident. CPVT mutations did not disrupt the secondary structure nor binding to ATP. |
### Instruction:
Is medical comorbidity associated with persistent index hip pain after total hip arthroplasty?
### Response:
| This study identified new correlates of moderate-severe hip pain after primary or revision THA, a much-feared outcome of hip arthroplasty. Patients with these comorbidities should be informed regarding the risk of moderate-severe index hip pain, so that they can have a fully informed consent and realistic expectations. |
### Instruction:
Is the surgical Apgar score strongly associated with intensive care unit admission after high-risk intraabdominal surgery?
### Response:
| The SAS is strongly associated with clinical decisions regarding immediate ICU admission after high-risk intraabdominal surgery. These results provide an initial step toward understanding whether intraoperative hemodynamics and blood loss influence ICU triage for postsurgical patients. |
### Instruction:
Does confounding underlie the apparent month of birth effect in multiple sclerosis?
### Response:
| In the absence of adequate control for confounding factors, such as year and place of birth, our analyses indicate that the previous claims for association of multiple sclerosis with month of birth are probably false positives. |
### Instruction:
Are `` You such a disappointment ! `` : negative emotions and parents ' perceptions of adult children 's lack of success?
### Response:
| Parents experience emotions associated with unmet goals and future concerns in relationships with less successful children. Mothers may respond emotionally to career and relationship success, whereas fathers may respond emotionally primarily to their child's career success. Findings underscore the importance of conside... |
### Instruction:
Does protein expression profiling of nuclear membrane protein reveal potential biomarker of human hepatocellular carcinoma?
### Response:
| These findings may have broader implications for understanding the mechanism of development of carcinoma. However, large scale studies will be required for further verification of their critical role in development and progression of HCC. |
### Instruction:
Do analysis of burn cases observed after the 2011 Van earthquake?
### Response:
| It was determined that the number of burn cases registered after the earthquake, the number of flame burns, the percentage of burns and the rate of mortality were higher than the data before the earthquake. |
### Instruction:
Is prior statin therapy associated with milder course and better outcome in acute pancreatitis -- a cohort study?
### Response:
| Prior statin treatment significantly reduces morbidity and mortality in acute pancreatitis. Further studies are needed to evaluate possible therapeutic use of statins in acute pancreatitis. |
### Instruction:
Do adventitial stem cells in vein grafts display multilineage potential that contributes to neointimal formation?
### Response:
| We demonstrate that during pathological conditions in vein grafting, the adventitia harbors stem/progenitor cells that can actively participate in the pathogenesis of vascular disease via differentiation into SMCs. |
### Instruction:
Does unphosphorylated calponin enhance the binding force of unphosphorylated myosin to actin?
### Response:
| This study provides direct molecular level-evidence that calponin enhances the binding force of unphosphorylated myosin to actin by cross-linking them and that this is reversed upon calponin phosphorylation. Thus, calponin might play an important role in the latch-state. |
### Instruction:
Do sublineages of lineage 4 ( Euro-American ) Mycobacterium tuberculosis differ in genotypic clustering?
### Response:
| Sublineage 183 is associated with genotypic clustering, evidence of its being more able to cause secondary cases than the other lineage 4 sublineages. This finding suggests that bacterial factors contribute to the pathogenesis of TB. Spoligotype and MIRU type cannot be used to infer sublineage. |
### Instruction:
Is endothelial dysfunction a marker of systemic response to the cardiac resynchronization therapy in heart failure?
### Response:
| ED is not an independent predictor of CRT response, but it is able to intercept the systemic effects of CRT and is an affordable marker of response to CRT, especially in patients unable to perform the 6MWT. |
### Instruction:
Does methanol extract of Evodia lepta display Syk/Src-targeted anti-inflammatory activity?
### Response:
| The anti-inflammatory effects of El-ME might be due to its suppression of Syk/Src and NF-κB. Considering the in vitro and in vivo efficacy of El-ME, Evodia lepta could be developed into an anti-inflammatory herbal remedy. |
### Instruction:
Does oxidative stress-mediated thrombospondin-2 upregulation impair bone marrow-derived angiogenic cell function in diabetes mellitus?
### Response:
| The upregulation of TSP-2 mediated by increased oxidative stress contributes to angiogenesis dysfunction in diabetic BMACs. |
### Instruction:
Do students ' expectations on the surgery clerkship exceed those of residents and faculty?
### Response:
| Overall, the expectations of the medical students, surgical residents, and surgical faculty on the surgery clerkship were well matched. However, there were some instances where the students thought they should be more involved in patient care than did the residents and the faculty. It is important for surgical educator... |
### Instruction:
Does ursodeoxycholic acid stabilize the bile salt export pump in the apical membrane in MDCK II cells?
### Response:
| We demonstrated that UDCA stabilizes Bsep protein in the apical membrane and increases its activity in MDCK II cells, presumably by retarding the endocytotic process. |
### Instruction:
Does hip resurfacing improve proprioception compared with THA?
### Response:
| Total hip resurfacing arthroplasty did not result in improved proprioception compared with THA. These results tend to refute the concept that improved proprioception is a rationale for selecting total hip resurfacing over THA in young patients. |
### Instruction:
Does sildenafil preserve exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction?
### Response:
| Sildenafil treatment in IPF with RVSD results in better preservation of exercise capacity as compared with placebo. Sildenafil also improves quality of life in subjects with RVH and RVSD. |
### Instruction:
Does celecoxib alleviate tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling?
### Response:
| Taken together, our experimental results indicate that this additive combination shows promising outcome in anti-metastatic and apoptotic studies. In a line, our preclinical studies evidenced that this additive combination of TAM and CXB is a potential drug candidate for treatment of breast tumors expressing high level... |
### Instruction:
Are men with celiac disease shorter than their peers in the general population?
### Response:
| Short stature is a well described phenomenon in pediatric CD with the potential for 'catch-up growth' on a gluten-free diet. However, among adults with CD who had attained final height before diagnosis, we found that men, not women, are shorter relative to the general population. |
### Instruction:
Does iL-10 promote tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma?
### Response:
| IL-10 production from lung tumors and immune cells promotes lung adenocarcinoma aggressiveness and patients with poor survival. We thus suggest that PI3K inhibitor combined with chemotherapy may potentially enhance tumor regression and improve patients' outcome and life quality. |
### Instruction:
Is low vitamin D concentration associated with increased mortality and morbidity after cardiac surgery?
### Response:
| Our analysis suggests that perioperative vitamin D concentration is not associated with clinically important outcomes, likely because the outcomes are overwhelmingly determined by other baseline and surgical factors. |
### Instruction:
Is sleep just for the brain : transcriptional responses to sleep in peripheral tissues?
### Response:
| Our data support the notion that the molecular consequences of sleep/wake behavioral state extend beyond the brain to include peripheral tissues. Sleep state induces a highly overlapping response in both heart and lung. We conclude that sleep enhances organ specific molecular functions and that it has a ubiquitous role... |
### Instruction:
Is persistence of left ventricular hypertrophy associated with increased cardiovascular morbidity and mortality in hypertensive patients with lower achieved systolic pressure during antihypertensive treatment?
### Response:
| These findings suggest that persistence of LVH in a subset of these patients may in part explain the lack of benefit found in hypertensive patients despite treatment to lower SBP. |
### Instruction:
Does severity of cardiac impairment in the early stage of community-acquired sepsis determine worse prognosis?
### Response:
| Septic cardiomyopathy occurs already at the early stage of disease and is of prognostic relevance. It might be recognized best, if cardiac function is correlated to afterload. |
### Instruction:
Is diabetes a useful diagnostic clue to improve the prognosis of pancreatic cancer?
### Response:
| Our analysis revealed that patients diagnosed in association with DM had better survival than symptomatic patients. Given the high prevalence of DM in PaC patients, DM can be a useful diagnostic clue for screening and lead to improvement of prognosis in PaC patients. |
### Instruction:
Is hypertriglyceridemic waist associated with increased carotid atherosclerosis in chronic kidney disease patients?
### Response:
| The hypertriglyceridemic waist phenotype was associated with worse carotid atherosclerosis in CKD patients. This suggests that the hypertriglyceridemic waist phenotype may be useful for predicting CVD risk in CKD patients. |
### Instruction:
Is ictal modulation of cardiac repolarization , but not of heart rate , lateralized in mesial temporal lobe epilepsy?
### Response:
| Seizure-related modulation of cardiac repolarization, but not of HR, appears to depend on the side of ictal activity, strengthening the hypothesis of asymmetric cerebral representation of cardiac function. The clinical relevance of this is unclear, but may indicate an increased risk of abnormal ictal QT prolongation in... |
### Instruction:
Is endothelial function well preserved in obese patients with mild obstructive sleep apnea?
### Response:
| Mild OSA was not observed to be associated with endothelial dysfunction. Although in mild OSA endothelial function is still preserved, lifestyle intervention with weight reduction did achieve an improvement in other obesity-related risk factors for cardiovascular diseases, thus highlighting the importance of early inte... |
### Instruction:
Is sex ratio at birth associated with first-trimester maternal thyrotropin in women receiving levothyroxine?
### Response:
| In women under pregestational treatment with levothyroxine, mean maternal first-trimester TSH is negatively associated with sex ratio at birth. This association has not been previously described. |
### Instruction:
Does reduced functional measure of cardiovascular reserve predict admission to critical care unit following kidney transplantation?
### Response:
| To our knowledge, this is the first prospective observational study to demonstrate the usefulness of CPET as a preoperative risk stratification tool for patients undergoing kidney transplantation. The study suggests that VO₂AT has the potential to predict perioperative morbidity in kidney transplant recipients. |
### Instruction:
Is progressive rise in red cell distribution width associated with poor outcome after transcatheter aortic valve implantation?
### Response:
| Baseline RDW ≥ 15.5% and a rising RDW over time strongly correlate to an increased risk of death post-TAVI, and could be used to refine risk stratification. Investigating and ameliorating the causes of RDW expansion may improve survival. |
### Instruction:
Is low ATP level sufficient to maintain the uncommitted state of multipotent mesenchymal stem cells?
### Response:
| Under hypoxic conditions glycolysis provides sufficient energy to maintain MMSCs in an uncommitted state. |
### Instruction:
Does extracellular ATP regulate FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-7 cells?
### Response:
| Extracellular ATP induces the inactivation of FoxO transcription factors and cell cycle progression through the PI3K/Akt pathway in MCF-7 cells. |
### Instruction:
Is celiac disease increased in women with hip fractures and low vitamin D levels?
### Response:
| Vitamin D levels are markedly reduced in women with hip fractures, however hip fracture patients did not show a higher percentage of positive tissue transglutaminase levels compared with controls. These data suggest that routine testing for celiac disease among hip fracture patients may not be necessary in the absence ... |
### Instruction:
Are elevated homocysteine levels associated with low muscle strength and functional limitations in older persons?
### Response:
| These data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men. |
### Instruction:
Does development of acneiform rash predict response to lapatinib treatment in patients with breast cancer?
### Response:
| This study does not support the development of the acneiform rash as a predictor of clinical efficacy of lapatinib in the treatment of breast cancer. |
### Instruction:
Do parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer?
### Response:
| Our data identify a novel therapeutic approach to the treatment of FGFR3-mutant cancer, emphasizing the potential of combination approaches targeting both FGFR3 and EGFR. Our data extend the role of EGFR in mediating resistance to inhibitors targeting a mutant oncogene, showing that EGFR signaling can repress mutant FG... |
### Instruction:
Does family history correlate of digit ratio abnormalities in schizophrenia?
### Response:
| Overall, in patients, reversal of expected "directionality" in digit ratio was observed in our study with greater left 2D: 4D in male patients having a family history of schizophrenia being a novel finding. Reversal of sexual dimorphism has been linked to the pathogenesis of schizophrenia. It is possible that such reve... |
### Instruction:
Does sorafenib prolong liver regeneration after hepatic resection in rats?
### Response:
| In this rat model, the regenerating liver adapted to the proliferation-inhibitory effect of sorafenib during continuous treatment. Sorafenib given after hepatic resection did not completely inhibit liver regeneration, but it prolonged the regenerative phase in proportion to the length of treatment. |
### Instruction:
Does hypoxia induce the overexpression of microRNA-21 in pancreatic cancer cells?
### Response:
| MiR-21 is induced by hypoxia in pancreatic cancer cells via HIF-1α upregulation. MiR-21 overexpression allows cells to avoid apoptosis in a hypoxic microenvironment. Inhibition of miR-21 expression may increase cellular susceptibility to hypoxia in pancreatic cancer. |
### Instruction:
Does early postoperative radiotherapy improve progression free survival in patients with grade 2 meningioma?
### Response:
| Adjuvant radiotherapy is an important therapeutic tool in the treatment of patients with grade 2 meningioma. It delays tumor progression and reduces the need for further surgery. Adjuvant radiotherapy must be considered as a treatment option in oncological multidisciplinary meetings, regardless of the quality of surgic... |
### Instruction:
Has survival in systemic sclerosis with pulmonary arterial hypertension improved in the modern era?
### Response:
| Despite an improvement in clinical status, unlike in PAH, mortality in SSc has not improved since the introduction of epoprostenol. |
### Instruction:
Does sUZ12 depletion suppress the proliferation of gastric cancer cells?
### Response:
| We provide evidence suggesting that SUZ12 may be a potential therapeutic target for gastric cancer. |
### Instruction:
Does heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuate influenza severity?
### Response:
| Reduced CFTR expression modulates the innate immune response to influenza and alters disease pathogenesis. CFTR-mediated Cl(-) secretion is therefore an important host determinant of disease, and CFTR inhibition may be of therapeutic benefit in influenza. |
### Instruction:
Does an angiotensin-converting enzyme inhibitor modulate stromal-derived factor-1 through CD26/dipeptidyl peptidase IV to inhibit laser-induced choroidal neovascularization?
### Response:
| These results strongly suggest that the antiangiogenic effects of imidapril on laser-induced CNV partially involve the modulation of the CD26/SDF-1 signaling pathway. |
### Instruction:
Does prostaglandin E receptor subtype EP4 agonist serve better to protect cochlea than prostaglandin E1?
### Response:
| The selective activation of EP4 has a stronger protective effect on cochleae against noise trauma than does the broad activation of EPs by PGE1. |
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