question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does renal transplantation normalize baroreflex sensitivity through improvement in central arterial stiffness?
### Response:
| Our data suggest that RT normalizes BRS in ESRD patients by 6 months which follows the improvement in the AI and central pulse pressure. |
### Instruction:
Do mouse ES cells have a potential to differentiate into odontoblast-like cells using hanging drop method?
### Response:
| Mouse ES cells cultured by the 'hanging drop' method are able to differentiate into cells with odontoblast-specific physiological functions and cell-surface integrin protein expression. |
### Instruction:
Does acetaminophen enhance cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma?
### Response:
| Our results suggest that acetaminophen as a chemoenhancing adjuvant could improve the efficacy of cisplatin and paclitaxel in treating patients with ovarian carcinoma and other tumor types. |
### Instruction:
Is expression of VEGF and its receptors VEGFR1/VEGFR2 associated with invasiveness of bladder cancer?
### Response:
| Our results suggest that alterations in the expression of VEGF and VEGF receptors are associated with disease stage and recurrence. |
### Instruction:
Is bRCA1 expression epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2?
### Response:
| CtBP2 is an ovarian cancer oncogene that may play a significant role in epigenetically silencing BRCA1 function in sporadic epithelial ovarian cancer. CtBP2-specific inhibitors, such as MTOB, may be effective adjunct therapies in the management of patients with CtBP2-positive ovarian carcinoma. |
### Instruction:
Does gMF sever actin-Arp2/3 complex branch junctions by a cofilin-like mechanism?
### Response:
| GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch. This activity and mechanism are conserved in GMF homologs from evolutio... |
### Instruction:
Does doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice result in psoriasis-like arthritis?
### Response:
| Upon doxycycline administration, the doxycycline-inducible human TNFα-transgenic mouse displays the major features of inflammatory arthritis. It represents a unique animal model for studying the molecular mechanisms of arthritis, especially the early phases of disease genesis and tissue remodeling steps upon abrogation... |
### Instruction:
Is habenular commissure formation in zebrafish regulated by the pineal gland-specific gene unc119c?
### Response:
| We suggest that Unc119c, together with Arl3l1/2, plays an important role in modulating Wnt4a production and secretion during HC formation in the forebrain of the zebrafish embryo. |
### Instruction:
Is high expression of truncated GLI3 associated with poor overall survival in patients with non-small cell lung cancer?
### Response:
| Overexpression of GLI3TR in NSCLC, especially in adenocarcinoma, is associated with poor prognosis. GLI3TR expression is an independent prognostic factor in OS. GLI3TR may play an important role in the tumorigenesis of NSCLC. |
### Instruction:
Is age-related macular degeneration associated with increased proportion of CD56 ( + ) T cells in peripheral blood?
### Response:
| We found increased levels of circulating aged CD56(+) CD28(-) T cells in patients with AMD. Although this supports the notion of AMD as a systemic disease, it also suggests that the adaptive immune system is implicated in its pathogenesis. |
### Instruction:
Does salivary gland-sparing other than parotid-sparing in definitive head-and-neck intensity-modulated radiotherapy seem to jeopardize local control?
### Response:
| Over 92% of LR failures occurred "in-field" within the high dose region when using IMRT with a whole salivary gland-sparing strategy. Sparing SMG and OC in addition to PG thus appears a safe strategy. |
### Instruction:
Are enzymatically active Rho and Rac small-GTPases involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells?
### Response:
| The accumulation of the RhoA and Rac1 on the PVM and the requisite of their normal GTPase activity for efficient invasion implied their involvement and function in T. gondii invasion. |
### Instruction:
Does an In Vitro Evaluation of Fracture Reduction Achieved by Inflatable Bone tamp under Simulated Physiological Load?
### Response:
| Some height restoration was observed using the two bone tamps in fractured vertebral bodies under simulated physiological load. The fracture reduction achieved by the two inflatable bone tamps was equivalent. No significant difference between mean inflation pressures and failure load was demonstrated between the two gr... |
### Instruction:
Do early therapy with neuraminidase inhibitors for influenza A ( H1N1 ) pdm 2009 infection?
### Response:
| This study provides the first clinical evidence that early treatment with neuraminidase inhibitors in outpatient clinic decreased the estimated clinical severity of pH1N1pdm09 in apparently otherwise healthy pediatric inpatients. |
### Instruction:
Do body composition and energy expenditure predict ad-libitum food and macronutrient intake in humans?
### Response:
| Food and macronutrient intake are predicted by FFMI and to a lesser degree by FMI. FFM and FM may have opposing effects on energy homeostasis. |
### Instruction:
Does indexed maximal left atrial volume predict response to cardiac resynchronization therapy?
### Response:
| Patients with small iLAV result as better responders to CRT than larger one. iLAVmax is an independent predictor of LV reverse remodeling and allows to indentify the best candidates for CRT. |
### Instruction:
Are elevated IP-10 and IL-6 from bronchoalveolar lavage cells biomarkers of non-cavitary tuberculosis?
### Response:
| Increasing IP-10 and IL-6 production by BAL cells is associated with non-cavitary TB in patients who present with radiographically advanced TB. IP-10 and IL-6 may reflect an effective T-helper 1 immune control pathway for TB, attenuating tuberculous lung destruction. |
### Instruction:
Do pseudomonas aeruginosa burn wound infection in a dedicated paediatric burns unit?
### Response:
| The incidence of clinically significant burn wound infection is low in our unit, yet the morbidity due to debridement and re-grafting is significant. We observed very high resistance to topical povidone-iodine. Resistance to systemic antimicrobials is lower than that reported from other burns units. |
### Instruction:
Does brentuximab vedotin cause clinically relevant QTc interval prolongation in patients with CD30-positive hematologic malignancies?
### Response:
| There is no significant prolongation of the QT/QTc interval with brentuximab vedotin in patients with CD30-positive hematologic malignancies. |
### Instruction:
Do causal information on children 's attitudes and behavioural intentions toward a peer with obesity?
### Response:
| Information explaining overweight had a minimal positive effect on attitudes and no effect on intentions toward an overweight peer. |
### Instruction:
Does resveratrol protect vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress?
### Response:
| HG induces endothelial cell apoptosis through NF-κB/NADPH oxidase/ROS pathway, which was inhibited by resveratrol. Our findings provide new potential therapeutic targets against brain vascular complications of diabetes. |
### Instruction:
Is prediabetes an independent risk factor for incident heart failure , other cardiovascular events or mortality in older adults : findings from a population-based cohort study?
### Response:
| We found no evidence that prediabetes is an independent risk factor for incident HF, other cardiovascular events or mortality in community-dwelling older adults. These findings question the wisdom of routine screening for prediabetes in older adults and targeted interventions to prevent adverse outcomes in older adults... |
### Instruction:
Does an allotetraploid Brassica napus early-flowering mutant have BnaFLC2-regulated flowering?
### Response:
| BnaFLC2, but not the other BnaFLC genes, plays an important role in B. napus GX50 floral transition. |
### Instruction:
Does nitric oxide synthase inhibition reduce albumin induced lung damage in acute pancreatitis?
### Response:
| Lung and pancreatic damage induced by albumin administration for restoration of plasma volume in AP are reduced by iNOS inhibition. Awareness of this fact may be useful in high-risk patients who need to receive albumin for volume replacement. |
### Instruction:
Is cdkn1a a key mediator of rat pancreatic stellate cell senescence?
### Response:
| Cdkn1a plays a direct role in the process of rat PSC senescence. Additional Cdkn1a-independent pathways may contribute to the partial maintenance of a gene expression profile typical of senescent PSC. |
### Instruction:
Is flt-1 ( vascular endothelial growth factor receptor-1 ) essential for the vascular endothelial growth factor-Notch feedback loop during angiogenesis?
### Response:
| Elevated Notch signaling downstream of perturbed VEGF signaling contributes to aberrant flt-1(-/-) blood vessel formation. Notch signaling may be dispensable for blood vessel formation when VEGF signaling is below a critical threshold. |
### Instruction:
Does sex modulate approach systems and impulsivity in substance dependence?
### Response:
| Higher BAS and motor impulsivity in SDI women relative to SDI men and control women suggest that personality traits that have been previously associated with drug use may be modulated by sex. These factors may contribute to differences in the disease course observed in male compared to female drug users. |
### Instruction:
Are aLK rearrangements mutually exclusive with mutations in EGFR or KRAS : an analysis of 1,683 patients with non-small cell lung cancer?
### Response:
| Functional ALK rearrangements were mutually exclusive with EGFR and KRAS mutations in a large Western patient population. This lack of overlap was also observed in ALK-positive cancers with acquired resistance to crizotinib. |
### Instruction:
Does spinophilin loss correlate with poor patient prognosis in advanced stages of colon carcinoma?
### Response:
| Our data suggest that Spn downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma. |
### Instruction:
Does hCN4 dynamically mark the first heart field and conduction system precursors?
### Response:
| This study provides insight into contributions of first and second heart lineages to the CCS and highlights the potential use of HCN4 in conjunction with other markers for optimization of protocols for generation and isolation of specific conduction system precursors. |
### Instruction:
Does repetitive traumatic brain injury ( or concussion ) increase severity of sleep disturbance among deployed military personnel?
### Response:
| Multiple TBIs are associated with increased risk for and severity of sleep disturbance among male military personnel. |
### Instruction:
Is serum soluble Klotho protein level associated with residual diuresis in incident peritoneal dialysis patients?
### Response:
| Serum soluble Klotho protein concentration is inversely related to residual diuresis and renal phosphate clearance in incident PD patients. |
### Instruction:
Do objective and subjective socioeconomic gradients exist for sleep in children and adolescents?
### Response:
| Socioeconomic gradients were observed for multiple sleep measures in youth. Objective parental SEP was related with sleep complaints (e.g., sleep disturbances), and subjective SEP was related with sleep quality and daytime sleepiness. Findings suggest sleep may be one pathway underlying the socioeconomic gradient in he... |
### Instruction:
Is nanoparticle-induced photocatalytic head and neck squamous cell carcinoma cell death associated with autophagy?
### Response:
| The effect of autophagy on HNSCC viability after nanoparticle-induced photocatalytic treatment seems to depend on the impact of the physicochemical trigger. |
### Instruction:
Are colonoscopy results enhanced by use of magnet endoguide in specialist practice?
### Response:
| UPD is convenient to have, but not a necessity for colonoscopy. |
### Instruction:
Does rapid estrogen receptor signaling mediate estrogen-induced inhibition of vascular smooth muscle cell proliferation?
### Response:
| These findings support that PP2A activation via rapid, non-nuclear ER signaling may be a novel target for therapeutic approaches to inhibit VSMC proliferation, which plays a central role in atherosclerosis and restenosis. |
### Instruction:
Are increasing age and female gender associated with early knee replacement following arthroscopy?
### Response:
| The predictors of early knee replacement following arthroscopy were female sex, age over 60 years and hypertension, irrespective of type of operation. This work may contribute to national recommendations regarding the provision of arthroscopy for patients over 60 years. |
### Instruction:
Do mitogenomic sequences and evidence from unique gene rearrangements corroborate evolutionary relationships of myctophiformes ( Neoteleostei )?
### Response:
| Mitogenomic results from DNA sequences and unique gene orders corroborate morphology in phylogeny reconstruction and provide a likely scenario for the phylogenetic history of Myctophiformes. The extent of gene order rearrangements found within the mitochondrial genomes of myctophids is unique for phylogenetic purposes. |
### Instruction:
Is viscera and muscle protein synthesis in neonatal pigs increased more by intermittent bolus than by continuous feeding?
### Response:
| These results suggest that intermittent bolus feeding increases protein synthesis in muscles of different fiber types and visceral tissues to a greater extent than continuous feeding by stimulating translation initiation. |
### Instruction:
Is ultrasound elastography for fibrosis surveillance cost effective in patients with chronic hepatitis C virus in the UK?
### Response:
| Annual definitive fibroscan may be a cost-effective surveillance strategy to identify cirrhosis in patients with chronic HCV, thereby allowing access of these patients to HCC screening. |
### Instruction:
Does nicotine enhance ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver?
### Response:
| These results suggest that nicotine enhances ethanol-induced steatosis and collagen deposition, but nicotine has no effect on ethanol-induced inflammation. |
### Instruction:
Do cT/99mTc-GSA SPECT fusion images demonstrate functional differences between the liver lobes?
### Response:
| CT/(99m)Tc-GSA SPECT fusion images demonstrated that the function of the left lobe was significantly decreased compared with that of the right lobe in non-cirrhotic livers. |
### Instruction:
Is treatment of hepatitis C in compensated cirrhotic patients equally effective before and after liver transplantation?
### Response:
| HCV antiviral treatment is equally effective in compensated cirrhotics both before and after LT, which patients show a higher risk of premature treatment withdrawal and a reduced survival, independently of the achievement of SVR. |
### Instruction:
Do astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation?
### Response:
| APS suppresses TNFα-induced adhesion molecule expression by blocking NF-κB signaling and inhibiting ROS generation in HUVECs. The results suggest that APS may be used to treat and prevent endothelial cell injury-related diseases. |
### Instruction:
Is the rate of decline of glomerular filtration rate a predictor of long-term graft outcome after kidney transplantation?
### Response:
| Our results suggested that ΔeGFR12-3 may be an independent predictor of kidney allograft survival. Routine application of eGFR is strongly recommended to identify patients at risk for chronic allograft dysfunction. |
### Instruction:
Is transjugular intrahepatic portosystemic shunt for a wait list patient a contraindication for orthotopic liver transplant outcomes?
### Response:
| Transjugular intrahepatic portosystemic shunt does not seem to affect outcomes after a liver transplant. We suggest that clinicians recognized the location of the stent to prevent any difficulty during surgery. |
### Instruction:
Does subendocardial viability ratio predict cardiovascular mortality in chronic kidney disease patients?
### Response:
| This post hoc analysis shows that a reduction of SEVR values impacts cardiovascular mortality in CKD patients. |
### Instruction:
Is midbrain atrophy a biomarker of progressive supranuclear palsy pathology?
### Response:
| Midbrain atrophy is associated with the clinical presentation of PSPS, but not with the pathological diagnosis of PSP in the absence of clinical PSPS. This finding has important implications for the utility of midbrain measurements as diagnostic biomarkers for PSP pathology. |
### Instruction:
Does microRNA-128 coordinately target Polycomb Repressor Complexes in glioma stem cells?
### Response:
| MiR-128 is an important suppressor of PRC activity, and its absence is an early event in gliomagenesis. |
### Instruction:
Do coated meshes for hernia repair provide comparable intraperitoneal adhesion prevention?
### Response:
| Commercially available meshes with a layered coating deliver comparable adhesion reduction. The physical presence of a layered coating between the intraperitoneal content and the abdominal wall seems to be more important than the chemical properties of the coating in adhesion formation. |
### Instruction:
Does the diagnostic accuracy of transabdominal ultrasonography need to be considered when managing gallbladder polyps?
### Response:
| Despite improvement in TAUS technology, the accuracy for GB polyps remains poor. This needs to be considered when managing patients with TAUS-detected GB polyps. We recommend that the decision to operate on TAUS-detected GB polyps be largely based on symptoms, and following GB polyps with TAUS should be discouraged. |
### Instruction:
Is endothelial lipase a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium?
### Response:
| EL is a critical determinant of the effects of HDL on S1P-mediated vascular responses and acts on HDL to promote activation of S1P1, leading to Akt/eNOS phosphorylation and subsequent endothelial migration and angiogenesis. The role of EL in HDL-associated S1P effects provides new insights into EL action, the responses... |
### Instruction:
Does thrombus attenuation predict angiographic results of mechanical thrombectomy with stent retrievers?
### Response:
| In contrast to results of other revascularization procedures as published in a recent study, the angiographic result of mechanical thrombectomy with stent retrievers is not predicted by thrombus attenuation. |
### Instruction:
Is one-millimeter cancer-free margin curative for colorectal liver metastases : a propensity score case-match approach?
### Response:
| One-mm cancer-free resection margin achieved in patients with colorectal liver metastases should now be considered the standard of care. |
### Instruction:
Does sesamol prevent doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts?
### Response:
| Among the different doses tested, 50 μm of sesamol showed maximum protection against Dox-induced oxidative damage. This reflects the significance of sesamol in ameliorating the deleterious effects associated with cancer chemotherapy. |
### Instruction:
Do symptoms predict colorectal cancer in an FOB screened population?
### Response:
| Half the FOB screen-positive patients had bowel symptoms. Symptoms in these patients had no correlation with an increased rate of neoplasia. The PPV for neoplasia is superior in symptomatic and asymptomatic screen-positive patients when compared to conventional urgent symptom-based referral. |
### Instruction:
Does multiplex PCR testing require a robust multi-disciplinary strategy to effectively manage identified cases of chlamydial conjunctivitis?
### Response:
| New PCR technology has resulted in a shared care approach to address corresponding implications of testing. Effective communication with a structured protocol and a central point of contact has improved follow-up and ensures appropriate best practice management of chlamydial conjunctivitis. |
### Instruction:
Is parent-proxy perception of overweight adolescents ' health-related quality of life different according to adolescent gender and age and parent gender?
### Response:
| The differences between self-report of overweight adolescent and perceptions of their parents about the HRQoL of their children are influenced by adolescent gender and age and parent gender. |
### Instruction:
Is the microvascular response to transdermal iontophoresis of insulin mediated by nitric oxide?
### Response:
| The main finding is that iontophoresis of insulin induces a dose-dependent vasodilation in the skin, which could be suppressed after pretreatment with a NO synthase inhibitor. This suggests that vasodilation in the skin after iontophoresis of insulin is mediated by the NO pathway. |
### Instruction:
Are b chromosomes of rye highly conserved and accompanied the development of early agriculture?
### Response:
| The surprisingly conserved chromosome structure suggests that although the rye Bs experienced rapid evolution including multiple rearrangements at the early evolutionary stages, this process has slowed significantly and may have even ceased during its recent evolution. |
### Instruction:
Do complex fetal ovarian cysts cause problems even after regression?
### Response:
| Complex ovarian cysts lead to problems even after regression in the postnatal period and require operative intervention sooner or later. |
### Instruction:
Do t-type Ca²⁺ channels regulate the exit of cardiac myocytes from the cell cycle after birth?
### Response:
| The studies performed show that loss of functional TTCCs is associated with bi-nucleation and myocyte withdrawal from the cell cycle. Loss of α1G TTCCs slowed the transition from mono- to bi-nucleation and resulted in an adult heart with a greater number of small cardiac myocytes. These results suggest that TTCCs are i... |
### Instruction:
Are notch1 and Notch4 markers for poor prognosis of hepatocellular carcinoma?
### Response:
| Notch1 expression might be an independent predictor of both shorter disease-free survival and shorter disease-specific survival in HCC patients after curative resection. Notch4 overexpression might be an independent predictor of shorter disease-specific survival. Notch1 could be used as an immunohistochemical biomarker... |
### Instruction:
Does propofol inhibit the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression?
### Response:
| Propofol decreases hepatocellular carcinoma cell invasiveness, which is partly due to the down-regulation of MMP-9 expression by miR-199a. |
### Instruction:
Is iGF-IEc expression associated with advanced clinical and pathological stage of prostate cancer?
### Response:
| The present data demonstrate that the expression of IGF-IEc is positively-associated with more advanced stage and higher Gleason score of prostate carcinomas. |
### Instruction:
Does aging effects on ERP correlate of emotional word discrimination?
### Response:
| The findings indicate that inhibition elicited by aversive events is observed for word stimuli as well, and is most effective in the young. |
### Instruction:
Are pharmacogenetic variants in the DPYD , TYMS , CDA and MTHFR genes clinically significant predictors of fluoropyrimidine toxicity?
### Response:
| We have identified a panel of clinically useful pharmacogenetic markers predicting toxicity to fluoropyrimidine therapy. Dose reduction should be considered in patients carrying these sequence variants. |
### Instruction:
Does cue-induced smoking urge deplete cigarette smokers ' self-control resources?
### Response:
| Findings corroborate our hypothesis that resisting smoking urges depletes cigarette smokers' self-control resources and suggests that self-control capacity is governed by a limited resource. |
### Instruction:
Do six-month ischemic mice show sensorimotor and cognitive deficits associated with brain atrophy and axonal disorganization?
### Response:
| tMCAo in mice induces sensorimotor and cognitive impairments detectable at least up to 6 months postinjury, associated with brain atrophy, and axonal and myelin damage of the external capsule. These behavioral tests and anatomical investigations may represent important tools in translational studies in cerebral ischemi... |
### Instruction:
Does triggering receptor expressed on myeloid cells-2 protect against polymicrobial sepsis by enhancing bacterial clearance?
### Response:
| TREM-2 plays an important role in the host defense response to sepsis by enhancing bacterial clearance. |
### Instruction:
Does miR-99a exert anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer?
### Response:
| miR-99a repressed oral cancer cell migration and invasion partly through decreasing MTMR3 expression. MTMR3 may serve as a therapeutic target for oral cancer treatment. |
### Instruction:
Does previous vaccination modify both the clinical disease and immunological features in children with measles?
### Response:
| Previously vaccinated children who develop measles are likely to have less severe disease and serology results that may be inconclusive, particularly for IgM antibody if tested in the first few days after the rash onset. |
### Instruction:
Are younger women with diminished oocyte reserve more prone to meiosis errors leading to spontaneous abortion than their age peers with normal oocyte reserve?
### Response:
| Since low FSH stimulation protocols were purposely used for the group with diminished oocyte reserve, the data are consistent that the conclusion regarding poor oocyte quality in women with diminished oocyte reserve was mostly iatrogenic and related to the use of high-dosage FSH stimulation trying to create more oocyte... |
### Instruction:
Does altered neutrophil count at diagnosis of invasive meningococcal infection in children?
### Response:
| Invasive meningococcal disease is characterized by striking abnormalities in ANC, INC and/or ITR. Neutropenia was associated with a poor prognosis. Notably, without INCs, 37% of cases would have been missed. Automated methods not measuring immature white blood cells should be avoided when assessing febrile children. Se... |
### Instruction:
Do neither cyclosporine nor tacrolimus deteriorate endothelial function in renal transplant recipients assessed with reactive hyperernia index?
### Response:
| Vasodilatatory function of endothelium assessed by PAT in renal transplant recipients was not worse than in healthy people. It was not different between cyclosporine or tacrolimus. Arterial stiffness measured as AI% depend on age but not the calcineurin inhibitor, which showed little effect. |
### Instruction:
Does toll-like receptor stimulation increase phagocytosis of Cryptococcus neoformans by microglial cells?
### Response:
| Our observation suggests that stimulation of microglial cells by TLR agonists can increase the resistance of the brain against CNS infections caused by Cryptococcus neoformans. This may be of interest when an immunocompromised patient is unable to eliminate Cryptococcus neoformans despite antifungal therapy. |
### Instruction:
Is proExC a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas?
### Response:
| ProExC is a novel immunohistochemical marker for differentiating ECA from EMA and its inclusion in a panel of immunohistochemical markers including p16, ER, PR, and vimentin is recommended when there is morphological and clinical doubt as to the primary site of endocervical or endometrial origin. |
### Instruction:
Do role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases -- the 10-year update?
### Response:
| The last decade brought much new information that gave birth to the first therapies of chronic inflammatory diseases on the basis of neuroendocrine immune targets. In addition, a new theory linked evolutionary medicine, neuroendocrine regulation of distribution of energy-rich fuels, and volume regulation that can expla... |
### Instruction:
Is receptor interacting protein kinase 3 a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice?
### Response:
| RIP3 is an early mediator of APAP hepatotoxicity, involving modulation of mitochondrial dysfunction and oxidant stress. Controlling RIP3 expression could be a promising new approach to reduce APAP-induced liver injury, but requires complementary strategies to control mitochondrial dysfunction for long-term protection. |
### Instruction:
Does optimisation of coronary angiography exposures require a multifactorial approach and careful procedural definition?
### Response:
| The 75th percentile levels in this study represent the tentative reference levels and are 48.9, 44.2 and 56 Gy cm(2) for all exposures, single-plane- and biplane-specific exposures, respectively, and compare favourably with the diagnostic reference level values established elsewhere internationally, with only the UK an... |
### Instruction:
Do transcriptome and proteome data reveal candidate genes for pollinator attraction in sexually deceptive orchids?
### Response:
| Our comprehensive data set generated by combining transcriptome and proteome technologies allowed identification of candidate genes for pollinator attraction and reproductive isolation among sexually deceptive orchids. This includes genes for hydrocarbon and anthocyanin biosynthesis and regulation, and the development ... |
### Instruction:
Are circulating p53-responsive microRNAs predictive indicators of heart failure after acute myocardial infarction?
### Response:
| In the sera of post-AMI patients who experienced development of de-novo HF within 1 year of AMI onset, the levels of 3 p53-responsive microRNAs had been elevated by the early convalescent stage of AMI. Further investigations are warranted to confirm the usefulness of these circulating microRNAs for predicting the risk ... |
### Instruction:
Is worker education level a factor in self-compliance with dust-preventive methods among small-scale agate industrial workers?
### Response:
| The data suggest that noncompliance with use of dust-preventive methods could be the reason behind the higher prevalence of silicosis and health morbidity in agate workers, and that years of schooling plays a significant role in the increased usage and self-compliance with dust-preventive methods among agate workers. |
### Instruction:
Is insulin-like growth factor 1 associated with high myopia in a large Japanese cohort?
### Response:
| The results of the present study using a Japanese subset do not support the proposal that the IGF-1 gene determines susceptibility to high or extreme myopia in Caucasians and Chinese. Further studies are needed to confirm our reports in other populations and to identify the underlying genetic determinants of these ocul... |
### Instruction:
Does iL6 trans-signaling promote functional recovery of hypofunctional phagocytes through STAT3 activation during peritonitis?
### Response:
| These results indicate that augmentation of IL6 signaling appears to be critical for the effective management of hypofunctional neutrophils during severe inflammation, such as sepsis. |
### Instruction:
Does nQO1 activation regulate angiotensin-converting enzyme shedding in spontaneously hypertensive rats?
### Response:
| This is the first study demonstrating that ACE shedding is regulated by NQO1 activation, which is possibly correlated with relieving hypertension in SHR. These findings provide strong evidence suggesting that NQO1 might be a new target for ACE modulation and BP control. |
### Instruction:
Does deletion of regulatory T cells support the development of intestinal ischemia-reperfusion injuries?
### Response:
| Our study indicated that Tregs participate in intestinal inflammatory responses induced by IRI and that targeting Tregs could be a novel therapeutic approach to intestinal IRI. |
### Instruction:
Do preparation method and growth factor content of platelet concentrate influence the osteogenic differentiation of bone marrow stromal cells?
### Response:
| The biological activity of platelet concentrates differs according to preparation technique, which affects platelet and leukocyte content and GF availability. Because GF levels are not always optimal in subjects with defective bone healing, composition and bioactivity of PRP should be analyzed to test the reliability a... |
### Instruction:
Does smooth muscle cell transplantation improve bladder contractile function in streptozocin-induced diabetic rats?
### Response:
| During the 2-week follow-up period after transplantation, we noticed an increase in contractile response of the bladder correlating to a decrease in residual urine. Cell survival studies revealed a cell survival rate close to 1.5%. |
### Instruction:
Are neural crest cells required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets?
### Response:
| NCCs are required at earlier stages of arterial valve development than previously recognized, playing essential roles in positioning the cushions, and patterning the valve leaflets. Abnormalities in the process of NCC condensation at early stages of outflow cushion formation may provide a common mechanism underlying BA... |
### Instruction:
Does tapered fluted titanium stem in the management of Vancouver B2 and B3 periprosthetic femoral fractures?
### Response:
| We report encouraging short-term results in terms of survival of distal taper stems in the treatment of B2 and B3 periprosthetic fractures. Although subsidence was frequent, most migrated less than 3 mm without correlation to poor pain and functional scores. |
### Instruction:
Is mCAM expression associated with poor prognosis in non-small cell lung cancer?
### Response:
| MCAM expression in surgically treated NSCLC is clearly associated with lymph node metastasis and poor prognosis. |
### Instruction:
Does metabolomics reveal metabolic alterations by intrauterine growth restriction in the fetal rabbit brain?
### Response:
| IUGR leads to metabolic alterations in the fetal rabbit brain, involving neuronal viability, energy metabolism, amino acid levels, fatty acid profiles and oxidative stress mechanisms. Overall findings identified aspargine, ornithine, N-acetylaspartylglutamic acid, N-acetylaspartate and palmitoleic acid as potential met... |
### Instruction:
Does multimodal imaging in rats reveal impaired neurovascular coupling in sustained hypertension?
### Response:
| Impaired neurovascular coupling in the SHR evolves upon sustained hypertension. Antihypertensive monotherapy using verapamil or losartan is not sufficient to abolish this functional impairment. These deficits in neurovascular coupling in response to sustained hypertension might contribute to accelerate progression of n... |
### Instruction:
Does orally administered S-1 suppress circulating endothelial cell counts in metastatic breast cancer patients?
### Response:
| This exploratory study showed that GBL levels increased, VEGF levels decreased, and CEC levels were suppressed during S-1 administration. S-1 appears to have anti-angiogenic activity. |
### Instruction:
Are development of radiation pneumopathy and generalised radiological changes after radiotherapy independent negative prognostic factors for survival in non-small cell lung cancer patients?
### Response:
| Severe radiation pneumopathy and generalised radiographic changes were significant independent prognostic factors for survival. More studies on pathophysiology of radiation induced damage are necessary to fully understand the mechanisms behind it. |
### Instruction:
Is arginine68 an essential residue for the C-terminal cleavage of human Atg8 family proteins?
### Response:
| These results suggest Arg68 is an essential residue for the C-terminal cleavage of Atg8 family proteins during the autophagy process. |
### Instruction:
Does [ CD44 regulate epithelial-mesenchymal transition and metastasis in nasopharyngeal cancer cells ]?
### Response:
| CD44 positively regulates the metastatic ability of nasopharyngeal cancer cells, which is relevant to the process of EMT. |
### Instruction:
Do correlation between lipid profile and troponin I test results in patients with chest pain in Nepal?
### Response:
| Traditional lipid profile levels is still can be used in screening populations to identify the subjects with high risk of developing cardiac event in case if the laboratory set up has not troponin test facilities. |
### Instruction:
Is habitual use of push and pull plastic bottle caps more prevalent among children with recurrent acute otitis media?
### Response:
| Our preliminary data show a significantly increased prevalence of P&P plastic cap bottle habitual users among children with a history or RAOM and support the need for larger studies to confirm the role of using P&P bottles as risk factor of RAOM and to identify the age groups at higher risk. |
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