question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
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### Instruction:
Does sAG2A protein from Toxoplasma gondii interact with both innate and adaptive immune compartments of infected hosts?
### Response:
| Altogether, we demonstrate herein that recombinant SAG2A protein from T. gondii is immunologically relevant in the host-parasite interface and may be targeted in therapeutic and diagnostic procedures designed against the infection. |
### Instruction:
Is obstructive sleep apnea a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults?
### Response:
| OSA is associated with impaired glucose metabolism in obese, sleep deprived individuals. Since sleep apnea is common and frequently undiagnosed, health care providers should be aware of its occurrence and associated risks. |
### Instruction:
Does curculigoside promote osteogenic differentiation of bone marrow stromal cells from ovariectomized rats?
### Response:
| The data indicate that curculigoside could promote BMSC proliferation and induce osteogenic differentiation of BMSCs. The most profound response was observed with 100 µm curculigoside. These findings may be valuable for understanding the mechanism of the effect of curculigoside on bone, especially in relation to osteop... |
### Instruction:
Does fractal structure determine controlled release kinetics of monolithic osmotic pump tablets?
### Response:
| The fractal dimension can be used as a quantitative indicator reflecting the drug release performance and be regarded as a key indicator for the quality control of oral controlled drug delivery systems. |
### Instruction:
Does activation of renal haeme oxygenase-1 alleviate gentamicin-induced acute nephrotoxicity in rats?
### Response:
| Here is the first evidence demonstrating the protective effect of HO-1 against gentamicin-associated nephrotoxicity. Suppression of oxidative/inflammatory insults alongside the corresponding decline of apoptosis were presumably responsible for this renoprotection. |
### Instruction:
Is basolateral glycylsarcosine ( Gly-Sar ) transport in Caco-2 cell monolayers pH dependent?
### Response:
| The study showed that basolateral Gly-Sar transport in the intestinal cell line Caco-2 is proton-coupled. The inhibitor profile indicated that the transporter has broad substrate specificity. |
### Instruction:
Do development of a female attractant for the click beetle pest Agriotes brevis?
### Response:
| The plant-derived blends were shown to catch female A. brevis under field conditions when applied in traps. Of these, the four-component blend, given its relatively simple composition [(Z)-3-hexenyl acetate:methyl benzoate:(Z)-3-hexen-1-ol:methyl salicylate 300:5:30:30 mg bait(-1)], may be a suitable 'standard' blend f... |
### Instruction:
Does normalization of left ventricular ejection fraction after cardiac resynchronization therapy also normalize survival?
### Response:
| Normalization of LVEF by CRT improves survival to levels comparable to the general population. This observation favors the concept that some CRT candidates have a cardiomyopathy likely generated by the conduction abnormality that is reversible through biventricular pacing. |
### Instruction:
Does interleukin-1 Beta induce an inflammatory phenotype in human aortic valve interstitial cells through nuclear factor kappa Beta?
### Response:
| Interleukin-1β induced an inflammatory phenotype in human AVICs, which was prevented by inhibition of nuclear factor-κβ. These data implicate IL-1β in the pathogenesis of aortic stenosis. |
### Instruction:
Does supplementation with low concentrations of melatonin improve nuclear maturation of human oocytes in vitro?
### Response:
| The current study demonstrated that low concentration of exogenous MT could ameliorate nuclear maturation of human oocyte during rescue IVM, while high concentration of MT presented negative effects. |
### Instruction:
Do hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway?
### Response:
| Overall our findings reveal a novel signaling pathway by which hyaluronan can modulate inflammation and demonstrate the ability of hyaluronan fragments to induce the expression of type I interferons in response to tissue injury even in the absence of viral infection. This is independent of the pathway of the TLR2-MyD88... |
### Instruction:
Is an elevated gap between admission and A1C-derived average glucose levels associated with adverse outcomes in diabetic patients with pyogenic liver abscess?
### Response:
| A glycemic gap≥72 mg/dL, rather than admission hyperglycemia or chronic glycemic control, was significantly correlated with adverse outcomes in diabetic PLA patients. Poorer chronic glycemic control in diabetic PLA patients is associated with high incidence of KP infection, hypoalbuminemia and longer hospital stay. |
### Instruction:
Does altered precipitation affect plant hybrids differently than their parental species?
### Response:
| Increased reproduction in hybrids in the reduced precipitation regime indicates that postzygotic reproductive isolation may breakdown under imposition of dry conditions. These results suggest the potential for frequency of hybrids to increase if severe droughts become more common. |
### Instruction:
Are total cholesterol and lipoprotein composition associated with dry eye disease in Korean women?
### Response:
| DED in a Korean population was found to be associated with high serum cholesterol levelsThe results of this study highlight the significance of eye examinations and independent lipid profile monitoring in patients with dyslipidemia because of its possible correlation with DED progression. |
### Instruction:
Does postnatal systemic inflammation exacerbate impairment of hippocampal synaptic plasticity in an animal seizure model?
### Response:
| Intraperitoneal LPS injection on P14 induces higher cytokine secretion after KA-induced seizures, enhancing neuronal excitability, shortening seizure onset time and exacerbating neuronal degeneration and impairment of LTP formation in the hippocampal Schaffer collateral-CA1 region. Central nervous system inflammation d... |
### Instruction:
Does baicalein reduce lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production?
### Response:
| Our results suggested that suppressing JAK/STATs activation and interfering with ROS production might contribute to the anti-inflammatory action of baicalein in macrophages. |
### Instruction:
Do genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus?
### Response:
| The ABCB1 3435C>T SNP influences ABCB1 activity of T cells and the pharmacodynamic effect of tacrolimus in kidney transplant patients. |
### Instruction:
Is the fractionalization of physical activity throughout the week associated with the cardiometabolic health of children and youth?
### Response:
| The fractionalization of MVPA throughout the week was associated with insulin resistance. |
### Instruction:
Does low-dose combination of alendronate and atorvastatin reduce ligature-induced alveolar bone loss in rats?
### Response:
| The lower-dose combination of ALD+ATV (0.01 mg/kg + 0.3 mg/kg, respectively) demonstrated a protective effect on alveolar bone loss. |
### Instruction:
Is costal cartilage a superior implant material than conchal cartilage in the treatment of empty nose syndrome?
### Response:
| Costal cartilage is a more useful material than conchal cartilage as implants for the treatment of empty nose syndrome patients. |
### Instruction:
Does sET binding factor 1 ( SBF1 ) mutation cause Charcot-Marie-Tooth disease type 4B3?
### Response:
| We suggest that the compound heterozygous mutations in SBF1 are the underlying causes of a novel CMT4B subtype, designated as CMT4B3. We believe that this study will lead to mechanistic studies to discover the function of SBF1 and to the development of molecular diagnostics for CMT disease. |
### Instruction:
Is cerebral aneurysm treatment beginning to shift to low volume centers?
### Response:
| A trend toward less cerebral aneurysms being treated in high volume centers in 2009 and 2010 is worrisome because high volume centers are known to tend to have better outcomes. This trend is likely due to recent expansion of the neurointerventional workforce. |
### Instruction:
Are restless legs syndrome and daytime sleepiness prominent in myotonic dystrophy type 2?
### Response:
| RLS, EDS, and fatigue are frequent sleep disturbances in patients with DM2, while OSA and pRBD symptoms are not. EDS was independently associated with DM2 diagnosis, suggesting possible primary CNS hypersomnia mechanisms. Further studies utilizing objective sleep measures are needed to better characterize sleep comorbi... |
### Instruction:
Does oncoplastic breast conservation lead to a delay in the commencement of adjuvant chemotherapy in breast cancer patients?
### Response:
| OBCS seems as safe as WLE, Ms or MsIR in terms of delivery of adjuvant chemotherapy, and, therefore, should not adversely affect breast cancer outcome in this respect. |
### Instruction:
Are european mitochondrial haplogroups associated with CD4+ T cell recovery in HIV-infected patients on combination antiretroviral therapy?
### Response:
| European mitochondrial haplogroups might influence CD4+ recovery in HIV-infected patients following initiation with cART. Haplogroups J and T appear to be associated with a worse profile of CD4+ recovery, whereas haplogroup H was associated with a better CD4+ reconstitution. |
### Instruction:
Does subcutaneous golimumab induce clinical response and remission in patients with moderate-to-severe ulcerative colitis?
### Response:
| Treatment with subcutaneous golimumab induces clinical response, remission, and mucosal healing, and increases quality of life in larger percentages of patients with active UC than placebo. ClinicalTrials.gov Number: NCT00487539. |
### Instruction:
Does liver iron modulate hepcidin expression during chronically elevated erythropoiesis in mice?
### Response:
| We provide evidence that under conditions of excessive and effective erythropoiesis, liver iron regulates hepcidin expression through the BMP6/SMAD pathway. |
### Instruction:
Do different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics?
### Response:
| These data suggest that FCER1A polymorphisms not only drive IgE levels in the general population but that specific polymorphisms may also influence IgE in association with asthma, suggesting that disease-specific mechanisms in IgE regulation exist. |
### Instruction:
Does tumor volume add prognostic value in patients with organ-confined prostate cancer?
### Response:
| TV was an independent prognostic predictor of BCR in organ-confined prostate cancers and provided additional prognostic information with increased predictive accuracy. In contrast, TV did not increase the predictive accuracy in nonorgan-confined tumor. TV should be considered as a prognosticator in organ-confined tumor... |
### Instruction:
Is cerebellar volume linked to cognitive function in temporal lobe epilepsy : a quantitative MRI study?
### Response:
| Our findings suggest that cerebellar volume is not linked to IED in patients with TLE but is significantly associated with cognitive dysfunction. Our findings support recent hypotheses proposing that the cerebellum has a relevant functional topography. |
### Instruction:
Are arousal from sleep pathways affected by the prone sleeping position and preterm birth : preterm birth , prone sleeping and arousal from sleep?
### Response:
| Prone sleeping promoted CA responses in healthy preterm infants throughout the first six months of post-term age. We have previously suggested that in term infants enhanced CA represents a critical protection against a potentially harmful situation; we speculate that for preterm-born infants the need for this protectio... |
### Instruction:
Is abnormal expression of Toll-like receptor 4 associated with susceptibility to ethanol-induced gastric mucosal injury in mice?
### Response:
| Both deficient and excessive expression of TLR4 promotes ethanol-induced gastric mucosal injury. The underlying mechanism involves the MyD88/NF-κB signaling pathway and the HMGB1, TLR4 activator ligand. The increased expression of HMGB1 may lead to increased secretion and binding to TLR4, further stimulating the TLR4/M... |
### Instruction:
Is glioma grade associated with the accumulation and activity of cells bearing M2 monocyte markers?
### Response:
| Grade II and IV astrocytomas can be clearly differentiated on the basis of the expression of certain M2 markers in tumor tissues, whereas grade III astrocytomas exhibit a range of expression between the lower and higher grade specimens. The content of CD163(+) cells distinguishes grade III astrocytoma subsets with diff... |
### Instruction:
Does simultaneous treatment with azelnidipine and olmesartan inhibit apoptosis of Hl-1 cardiac myocytes expressing E334k cMyBPC?
### Response:
| Azelnidipine plus olmesartan or amlodipine plus valsartan inhibited apoptosis of HL-1 cells expressing E334K cMyBPC, and the former combination was more effective than the latter. |
### Instruction:
Does exercise intensity modulate nitric oxide and blood pressure responses in hypertensive older women?
### Response:
| Exercise intensity and NO release may exert a role in eliciting PEH in mildly hypertensive elderly women. |
### Instruction:
Is medial pectoral pedicle a reliable landmark for axillary lymph node dissection?
### Response:
| Relations between neurovascular structures in the axilla are predictable. The medial pectoral pedicle, which is consistently found and superficially located, could be used as a landmark for ALND. |
### Instruction:
Is metabolic syndrome strictly associated with parental obesity beginning from childhood?
### Response:
| Parental obesity was strictly associated with MetS in all children and should be considered in clinical practice. In older children, wrong lifestyle and dietary habits were related to parental obesity. |
### Instruction:
Does interferon-α sensitize HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation?
### Response:
| HBx protein can induce MDR of HBV-related HCC by activating the NF-κB pathway, which can be partly abolished by IFN-α treatment. |
### Instruction:
Is influenza vaccination associated with detection of noninfluenza respiratory viruses in seasonal studies of influenza vaccine effectiveness?
### Response:
| Influenza vaccination was not associated with detection of noninfluenza respiratory viruses. Use of influenza-negative controls did not generate a biased estimate of vaccine effectiveness due to an effect of vaccination on other respiratory virus infections. |
### Instruction:
Does loss of histone deacetylases 1 and 2 in hepatocytes impair murine liver regeneration through Ki67 depletion?
### Response:
| Both HDAC1 and HDAC2 play crucial roles in the regulation of liver regeneration. The loss of HDAC1/2 inhibits Ki67 expression and results in defective hepatocyte mitosis and impaired liver regeneration. |
### Instruction:
Does micellar delivery of flutamide via milk protein nanovehicles enhance its anti-tumor efficacy in androgen-dependent prostate cancer rat model?
### Response:
| Overall this approach suggested that CAS micelles might be an ideal candidate for intravenous delivery of hydrophobic anticancer drugs. |
### Instruction:
Does osteoprotegerin reduce the development of pain behaviour and joint pathology in a model of osteoarthritis?
### Response:
| Our data suggest that early targeting of osteoclasts may reduce pain associated with OA. |
### Instruction:
Is microglial activation induced by traumatic brain injury suppressed by postinjury treatment with hyperbaric oxygen therapy?
### Response:
| Our results demonstrate that treatment of TBI during the acute phase of injury can attenuate microgliosis and proinflammatory cytokine TNF-α expression resulting in a neuroprotective effect. Even treating TBI with HBO after 8 h had a therapeutic effect. |
### Instruction:
Is timing everything-colectomy performed on Monday decreases length of stay?
### Response:
| Segmental colectomies have a significantly decreased length in stay when performed on Monday compared with the rest of the week. The decrease is independent of surgeon, comorbidities, and complications. This difference may be the result of patients' taking full advantage of hospital resources and ancillary support. Cos... |
### Instruction:
Do b56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity?
### Response:
| This study further indicates the importance of B56γ-PP2A in tumorigenesis. |
### Instruction:
Do hDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS?
### Response:
| This study suggests that altering K-RAS acetylation is a feasible approach to limiting tumorigenic potential. |
### Instruction:
Is single-nucleotide polymorphism array genotyping equivalent to metaphase cytogenetics for diagnosis of Turner syndrome?
### Response:
| Our study is the first systematic comparison between the two methods and supports the utility of SNP array genotyping to address clinical and research questions in Turner syndrome. |
### Instruction:
Is prior buprenorphine experience associated with office-based buprenorphine treatment outcomes?
### Response:
| Prior buprenorphine experience was common and associated with better retention. Understanding how prior buprenorphine experience affects treatment outcomes has important clinical and public health implications. |
### Instruction:
Does [ A novel mutation of cartilage oligomeric matrix protein gene underlie multiple epiphyseal dysplasia ]?
### Response:
| A novel c.956 A>T substitution mutation has been identified in a patient featuring MED. |
### Instruction:
Is television screen time , but not computer use and reading time , associated with cardio-metabolic biomarkers in a multiethnic Asian population : a cross-sectional study?
### Response:
| In this urban Asian population, television screen time was associated with worse levels of various cardio-metabolic risk factors. This may reflect detrimental effects of television screen time on dietary habits rather than replacement of physical activity. |
### Instruction:
Is angiopoietin-like protein 2 associated with chronic kidney disease in a general Japanese population : the Hisayama Study?
### Response:
| Elevated serum Angptl2 is associated with the likelihood of CKD in the general population. |
### Instruction:
Does chronic amiodarone therapy impair the function of the superior sinoatrial node in patients with atrial fibrillation?
### Response:
| In a quarter of the AF patients, amiodarone causes superior SAN dysfunction, which results in a downward shift of the EAS and reduced P-wave amplitude in leads II, III and aVF at baseline and during isoproterenol infusion. |
### Instruction:
Are measures of balance performance affected by a rested versus fatigued testing condition in people with multiple sclerosis?
### Response:
| Measures of balance performance and acute fatigue may be affected by rested versus fatigued testing conditions in people with MS. However, no significant relationships between changes in balance and fatigue were identified. Therefore, clinicians should use caution when making assumptions about the influence of fatigue ... |
### Instruction:
Does severity of hydronephrosis correlate with tumour invasiveness and urinary bladder recurrence of ureteric cancer?
### Response:
| Hydronephrosis grade >2 is associated with non-organ-confined ureteric cancer and with bladder cancer recurrence. Non-organ-confined pathology is still the most important predictor for local and distant oncological failure. |
### Instruction:
Does clarithromycin substantially increase steady-state bosentan exposure in healthy volunteers?
### Response:
| Clarithromycin substantially increases the exposure to bosentan, suggesting that dose reductions may be necessary. |
### Instruction:
Do down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer?
### Response:
| These results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation. Our findings highlight the functional associations of intronic miRNAs and their host genes in thyroid carcinogenesis. |
### Instruction:
Do the correlates of preschoolers ' compliance with screen recommendations exist across multiple domains?
### Response:
| Public health programs should take account of the sex-specific nature of correlates of preschool children's screen time. Preschool children across all demographic groups need support to engage in less screen use. Parents may benefit from education and parenting skills to minimize potentially harmful effects of excessiv... |
### Instruction:
Is caveolin-1 , through its ability to negatively regulate TLR4 , a crucial determinant of MAPK activation in LPS-challenged mammary epithelial cells?
### Response:
| CAV-1 gene silencing promotes MAPK activation via TLR4 signaling in human mammary epithelial cells response to LPS. |
### Instruction:
Is systematic review of antiretroviral-associated lipodystrophy : lipoatrophy , but not central fat gain , an antiretroviral adverse drug reaction?
### Response:
| There is clear evidence of a causal relationship between NRTIs (especially thymidine analogues) and lipoatrophy, with concomitant PIs possibly having an ameliorating effect or efavirenz causing additive toxicity. By contrast, central fat gain appears to be a consequence of treating HIV infection, because it is not diff... |
### Instruction:
Is carbohydrate antigen 19-9 ( CA 19-9 ) an independent prognostic indicator in pseudomyxoma peritonei post cytoreductive surgery and perioperative intraperitoneal chemotherapy?
### Response:
| Our study provides relevant prognostic information for the DPAM subtype in staging and prioritizing surgery; as even in apparently indolent disease, some patients have poorer survival. CA 19-9 elevation may also be useful in identifying patients who would potentially benefit from adjuvant therapy and/or closer post-ope... |
### Instruction:
Do common biomarkers of oxidative stress reflect cardiovascular dys/function in rats?
### Response:
| Commonly used biomarkers of oxidative stress cannot reliably predict cardiovascular dys/function in experimental rats. |
### Instruction:
Does rNA-seq analysis reveal extensive transcriptional plasticity to temperature stress in a freshwater fish species?
### Response:
| Annotated blast matches reveal that differentially expressed genes correspond to critical metabolic pathways previously shown to be important for temperature tolerance in other fish species. Our results indicate that rainbowfish exhibit predictable plastic regulatory responses to temperature stress and the genes we ide... |
### Instruction:
Does prenatal stress induce increased striatal dopamine transporter binding in adult nonhuman primates?
### Response:
| Maternal exposure to mild daily stress during pregnancy yielded increases in striatal DAT availability that were apparent in adult offspring and were associated with behavioral characteristics reflecting tactile hyperresponsivity, a condition associated with problem behaviors in children. |
### Instruction:
Is mesothelin more useful in pleural effusion than in serum in the diagnosis of pleural mesothelioma?
### Response:
| PE-SMRP detection has a superior diagnostic accuracy than S-SMRP detection in the diagnosis of MPM. |
### Instruction:
Is early-onset neutropenia during perioperative chemotherapy predictive of increased survival in patients with completely resected non-small cell lung cancer : a retrospective analysis?
### Response:
| Early-onset CIN during perioperative chemotherapy is predictive of better OS and DFS in patients with completely resected NSCLC. |
### Instruction:
Are genetic variants in HHIP associated with FEV1 in subjects with chronic obstructive pulmonary disease?
### Response:
| Genetic variants in HHIP are associated with lung function in subjects with COPD. |
### Instruction:
Does chronic Ritalin administration during adulthood increase serotonin pool in rat medial frontal cortex?
### Response:
| Our findings demonstrated both short- and long-term effects of Ritalin on frontal serotonergic system after withdrawal period. |
### Instruction:
Do metabolites associate with kidney function decline and incident chronic kidney disease in the general population?
### Response:
| Baseline serum concentrations of spermidine and two metabolite ratios were associated with kidney function change over subsequent years in the general population. In separate analyses, baseline serum metabolites were able to predict incident CKD to a similar but not better extent than selected clinical parameters. Our ... |
### Instruction:
Does plasma NGAL similarly predict acute kidney injury in sepsis and nonsepsis?
### Response:
| Sepsis enhances the production of plasma NGAL in critically ill adult patients irrespective of the presence of AKI. However, the diagnostic test accuracy for AKI is unaffected by sepsis, although optimal cutoff values are elevated. |
### Instruction:
Is overexpression of hypoxia inducible factor-1 alpha an independent risk factor for recurrence after curative resection of colorectal liver metastases?
### Response:
| Our results suggest a possible induction of HIF-1α expression by mutant PIK3CA. The expressions of HIF-1α and VEGF in liver metastases significantly correlated with those in the corresponding primary tumor. Overexpression of HIF-1α was an independent risk factor for recurrence after curative resection of CRLM, suggesti... |
### Instruction:
Is chronic kidney disease associated with increased platelet activation and poor response to antiplatelet therapy?
### Response:
| Patients with CKD exhibit increased platelet activation, and an attenuated response to dual antiplatelet therapy compared with patients without renal insufficiency. |
### Instruction:
Is lymph node ratio a stronger prognostic factor than microsatellite instability in colorectal cancer patients : results from a 7 years follow-up study?
### Response:
| According to our results the MSI-H status was associated with particular features (right locations/locally advanced tumors). The results of a long-term follow-up indicate a trend for better survival in MSI-H vs MSS patients. Notably, an increased LNR is associated with worse survivals, both at the univariate and multiv... |
### Instruction:
Does heart rate variability remain reduced and sympathetic tone elevated after temporal lobe epilepsy surgery?
### Response:
| These findings show that in patients with intractable temporal lobe epilepsy, HRV is decreased globally in both sympathetic and parasympathetic domains. While the total HRV remains reduced throughout the postoperative periods, the LF/HF ratio, i.e., sympathovagal balance is altered, in favor of parasympathetic side ear... |
### Instruction:
Do otostegia persica extraction on healing process of burn wounds?
### Response:
| Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site. |
### Instruction:
Does the multicomponent medication lymphomyosot improve the outcome of experimental lymphedema?
### Response:
| Lymphomyosot may act through inflammatory and wound repair pathways to reduce experimental lymphedema. Its ability to regulate inflammation as well as assist in tissue repair and extracellular formation may allow for the production of a scar-free matrix bridge through which migrating cells and accumulated interstitial ... |
### Instruction:
Are genetic variants in telomerase-related genes associated with an older age at diagnosis in glioma patients : evidence for distinct pathways of gliomagenesis?
### Response:
| Carrying a greater number of risk alleles might be expected to decrease age at diagnosis. However, glioma susceptibility conferred by variation in telomerase-related genes did not follow this pattern. This supports the hypothesis that telomerase-related mechanisms of telomere maintenance are more associated with glioma... |
### Instruction:
Does exercise training improve activity in adolescents with congenital heart disease?
### Response:
| Exercise training is safe, feasible and beneficial in adolescents with CHD. Psychological techniques can be employed to maximise the impact of interventions. |
### Instruction:
Does gefitinib selectively inhibit tumor cell migration in EGFR-amplified human glioblastoma?
### Response:
| These data provide the first identification of patient-to-patient variation in tumor cell migration in living human tumor tissue. We found that EGFR-amplified GBM are inherently more efficient in their migration and can be effectively targeted by gefitinib treatment. These data suggest that stratified clinical trails a... |
### Instruction:
Does anemia increase the risk of renal cortical and medullary hypoxia during cardiopulmonary bypass?
### Response:
| During CPB, renal O2 delivery was transiently jeopardized, but recovered after 1 hr. Anemia-CPB resulted in a dramatic and sustained reduction in renal cortical and medullary PO2, which suggests an increased risk of renal hypoxic injury with anemia. |
### Instruction:
Are state , but not trait , measures of persistence related to negative affect?
### Response:
| These findings suggest that behavioral, but not self-report, measures of persistence are related to negative affect. We argue that these behavioral measures capture "state" persistence whereas the self-report measures capture "trait" persistence. These data also lend support to the self-control strength model by sugges... |
### Instruction:
Do smokers report greater demand for alcohol on a behavioral economic purchase task?
### Response:
| College student heavy drinkers who also smoke cigarettes exhibit increased demand for alcohol. Smokers in this high-risk developmental stage may thus be less sensitive to price and other contingencies that would otherwise serve to modulate drinking and may require more intensive intervention approaches. |
### Instruction:
Is functional thermogenic beige adipogenesis inducible in human neck fat?
### Response:
| Beige adipocytes are thermogenic in humans. FGF21 is a beige adipokine capable of promoting a brown fat-like thermogenic program in WAs. |
### Instruction:
Is trp64Arg ( rs4994 ) polymorphism of β3-adrenergic receptor gene associated with hyperuricemia in a Chinese male population?
### Response:
| Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia. |
### Instruction:
Do defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis?
### Response:
| Th-cell immunodeficiency in cirrhosis is explained by a universal defect in thymopoiesis exacerbated by splenic pooling and activation-driven cell-death induced by bacterial translocation. |
### Instruction:
Do no need for broad-spectrum empirical antibiotic coverage after surgical drainage of orthopaedic implant infections?
### Response:
| Provided that surgical drainage is performed, broad-spectrum antibiotic coverage does not enhance remission of orthopaedic implant infections during the first three days. If empirical agents are prescribed from the first day of infection, narrow-spectrum penicillins or cephalosporins can be considered to avoid unnecess... |
### Instruction:
Does the cellular isopeptidase T deubiquitinating enzyme regulate Kaposi 's sarcoma-associated herpesvirus K7 degradation?
### Response:
| IsoT1 disassembles of free ubiquitin chains to facilitate K7 degradation. |
### Instruction:
Is platelet Hyperaggregability Highly Prevalent in Patients With Chronic Kidney Disease : An Underestimated Risk Indicator of Thromboembolic Events?
### Response:
| Patients with CKD exhibit a hitherto unappreciated high prevalence of platelet hyperaggregability indicating sticky platelet syndrome. Laboratory testing of platelet hyperaggregability may supplement the assessment of thromboembolic complications in patients with CKD. |
### Instruction:
Does chronic resveratrol consumption improve brachial flow-mediated dilatation in healthy obese adults?
### Response:
| Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults. |
### Instruction:
Do maternal cotyledons at birth predict blood pressure in childhood?
### Response:
| Our study has shown that a large number of maternal cotyledons is associated with raised blood pressure in childhood. The associations differ in the two sexes. |
### Instruction:
Is local atopy more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy?
### Response:
| This study provided evidence that there was an important role for allergic inflammation in the ATH. The inconsistency in sIgE expression between adenotonsillar and serum suggests a role of local atopy in childhood ATH. |
### Instruction:
Is proMetalloproteinase-10 associated with brain damage and clinical outcome in acute ischemic stroke?
### Response:
| Increased serum proMMP-10 after acute ischemic stroke, associated with TNFα, is a new marker of brain damage and poor outcome. |
### Instruction:
Does high-temperature mass spectrometric study of the vaporization processes and thermodynamic properties of melt in the PbO-B2O3-SiO2 system?
### Response:
| Partial pressures of the vapor species over PbO-B2O3-SiO2 melts were measured at 1100 K in the wide range of compositions using the Knudsen mass spectrometric method. The data enabled the PbO, B2O3, and SiO2 activities in these melts to be derived and provided evidence of their negative deviations from ideal behavior. |
### Instruction:
Is in situ laser fenestration during emergent thoracic endovascular aortic repair an effective method for left subclavian artery revascularization?
### Response:
| In situ retrograde laser fenestration is a feasible and effective option for LSA revascularization during TEVAR involving a spectrum of acute thoracic aortic pathology. Laser fenestration provides a rapid, reproducible method of fenestrating the endograft material. The high technical success, low fenestration-related m... |
### Instruction:
Is history of a suspected delirium more common in dementia with Lewy bodies than Alzheimer 's disease : a retrospective study?
### Response:
| A greater proportion of those presenting and diagnosed with DLB had a documentation of a suspected delirium than those diagnosed with AD. Delirium may lead to a higher risk of DLB as opposed to other forms of dementia, or delirium may, at least in some cases, represent the early stages of DLB. These data suggest that a... |
### Instruction:
Does endothelium-targeted Delta-like 1 promote hematopoietic stem cell expansion ex vivo and engraftment in hematopoietic tissues in vivo?
### Response:
| D1R might be applied in improving both HSC expansion ex vivo and HSC engraftment in vivo in transplantation. |
### Instruction:
Does immunoprofiling of oral squamous cell carcinomas reveal high p63 and survivin expression?
### Response:
| The high frequency of tumor cells expressing p63 and survivin highlights the role of these proteins in the malignant transformation of oral epithelium. Collectively, our results suggest that p63 and survivin may constitute attractive targets for cancer therapy in patients with OSCC. |
### Instruction:
Is laparoscopic bile duct exploration via choledochotomy followed by primary duct closure feasible and safe for the treatment of choledocholithiasis?
### Response:
| Primary duct closure following LCBDE is safe, can be employed routinely as an alternative to T-tube insertion, and has a short hospital stay and low morbidity rate. |
### Instruction:
Does lower reoperation rates with the use of fibrin sealant versus tack for mesh fixation?
### Response:
| Fibrin sealant was superior to tacks for mesh fixation in laparoscopic groin hernia repair with regard to reoperation rates. The study could not differentiate between different hernia defect sizes, and future studies should therefore explore whether the superior effect of fibrin sealant applies for all hernia types and... |
### Instruction:
Do rhythmical and periodic EEG patterns predict short-term outcome in critically ill patients with subarachnoid hemorrhage?
### Response:
| Using the ACNS Research Terminology, it is shown that rhythmical and periodic patterns are very common in critically ill patients with subarachnoid hemorrhage. However, the presence and the abundance of these patterns did not predict short-term outcome in this prospective, single-center observational study. We were una... |
### Instruction:
Does two chromosome 9p21 haplotype block distinguish between coronary artery disease and myocardial infarction risk?
### Response:
| Variants/haplotypes at 2 blocks are distinguished at 9p21; those at 1 block predispose to atherosclerosis, whereas those at the other predispose to MI among patients with preexisting CAD. |
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