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### Instruction:
Do nK cells improve control of friend virus infection in mice persistently infected with murine cytomegalovirus?
### Response:
| Our data demonstrate for the first time that a persistent CMV infection induces long-lasting NK cell responses that can enhance immunity to primary retroviral infections. To our knowledge, studies investigating primary HIV infection have not analyzed the role of the CMV seropositivity in these patients. Our observation... |
### Instruction:
Do increased crown-to-implant ratio may not be a risk factor for dental implant failure under appropriate plaque control?
### Response:
| These findings suggest that increased C/I may not be a risk factor for implant failure if the peri-implant mucosa is kept healthy, as was the case in this animal model. |
### Instruction:
Do educational Experiences Residents Perceive As Most Helpful for the Acquisition of the ACGME Competencies?
### Response:
| Our findings reinforce the importance of learning from role models during patient care activities and the heterogeneity of learning activities needed for acquiring all 6 competencies. |
### Instruction:
Are how baseline , new-onset , and persistent depressive symptoms associated with cardiovascular and non-cardiovascular mortality in incident patients on chronic dialysis?
### Response:
| This study showed that different courses of depressive symptoms were associated with a poor survival after the start of dialysis. In particular, temporary depressive symptoms at the start of dialysis may be a strong marker for non-cardiovascular mortality, whereas persistent depressive symptoms were associated with bot... |
### Instruction:
Is extra-thoracic tumor burden but not thoracic tumor burden on ( 18 ) F-FDG PET/CT an independent prognostic biomarker for extensive-disease small cell lung cancer?
### Response:
| These data provide evidence indicating that extra-thoracic tumor burden but not thoracic tumor burden is an independent prognostic biomarker for ED-SCLC, and support further exploration of novel treatment strategies targeting extra-thoracic tumor burden in order to improve the clinical outcomes of patients with ED-SCLC... |
### Instruction:
Is somatization associated with deficits in affective Theory of Mind?
### Response:
| Relative to Medical Controls, a deficit in the encoding and reporting of emotion when the emotional content of the stimulus is conveyed in action occurs equally in Conversion Disorder and Functional Somatic Syndrome patients and is consistent with previous findings in somatoform disorder inpatients. Difficulty with "co... |
### Instruction:
Does diagnostic ability of retinal nerve fiber layer map to detect localized retinal nerve fiber layer defects?
### Response:
| RNFL thickness and significance maps could be used to distinguish eyes with localized RNFL defects from healthy eyes more effectively than cpRNFL thickness and macular inner retina thickness measurements. |
### Instruction:
Does ethanol divert early neuronal differentiation trajectory of embryonic stem cells by disrupting the balance of lineage specifiers?
### Response:
| These findings provided an ethanol-response gene signature and pointed to the transcriptional dynamics underlying lineage imbalance that may be relevant to FASD phenotype. |
### Instruction:
Does [ The value of chest CT feature evaluating the severity and prognosis for acute pancreatitis ]?
### Response:
| Bilateral pleural effusion/pulmonary consolidation suggest SAP to some extent. Measuring the values of pleural effusion/pulmonary consolidation has some clinic cost for assessing the severity and the prognosis of Acute Pancreatitis. |
### Instruction:
Is delta-6-desaturase gene polymorphism associated with lipoprotein oxidation in vitro?
### Response:
| We conclude that FADS2 genotype may play a role in peroxidation susceptibility of lipoproteins. |
### Instruction:
Is thrombocytopenia in Plasmodium vivax malaria related to platelets phagocytosis?
### Response:
| Collectively, our findings indicate that platelet phagocytosis may contribute to thrombocytopenia found in vivax malaria. Finally, we believe that this study opens new avenues to explore the mechanisms involved in platelet dysfunction, commonly found in vivax malaria patients. |
### Instruction:
Is peripheral T-cell apoptosis differentially affected by antiretroviral regimens in HIV-infected patients?
### Response:
| In this cross-sectional study on HIV-infected patients, direct ex vivo spontaneous T-cell apoptosis rates are not differentially affected by NNRTI- or PI-based cART. |
### Instruction:
Do orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons?
### Response:
| The results indicate that in cultured rat cortical neurons orexin receptors are also coupled to inositol phosphates signaling pathway. |
### Instruction:
Are abnormal Neurodevelopmental Outcomes Common in Children with Transient Congenital Hyperinsulinism?
### Response:
| Abnormal neurodevelopment was evident in one third of children with both T-CHI and P-CHI, early presentation and severe CHI being risk factors. Early recognition and rapid correction of hypoglycemia are advocated to avoid abnormal neurodevelopment in children with CHI. |
### Instruction:
Is pad count a poor measure of the severity of urinary incontinence?
### Response:
| There was little correlation between the number of pads used and the severity of urinary incontinence (r=0.26). These data suggest that pad count should not be used as an objective measure of incontinence severity. Instead, pad weight on a 24-hour pad test should be used. |
### Instruction:
Is epidermal growth factor receptor overexpression a marker for adverse pathologic features in papillary thyroid carcinoma?
### Response:
| EGFR-H could be an important biomarker for aggressive PTCs, particularly in BRAF wild-type PTCs. Despite EGFR-H in PTC, follicular thyroid carcinoma, and anaplastic thyroid carcinoma by immunohistochemistry, somatic EGFR mutations were absent. Therefore, future investigations of EGFR should consider histologic and immu... |
### Instruction:
Do plasma osteoprotegerin levels increase with the severity of cerebral artery atherosclerosis?
### Response:
| Plasma OPG levels were significantly associated with the presence and severity of cerebral atherosclerosis. This finding suggests that plasma OPG might have a role in cerebral atherosclerosis. |
### Instruction:
Does antagonism of histamine H4 receptors exacerbate clinical and pathological signs of experimental autoimmune encephalomyelitis?
### Response:
| H4 receptor blockade was detrimental in EAE. Given the interest in the development of H4 receptor antagonists as anti-inflammatory compounds, it is important to understand the role of H4 receptors in immune diseases to anticipate clinical benefits and also predict possible detrimental effects. |
### Instruction:
Are high peripheral levels of h-FABP associated with poor prognosis in end-stage heart failure patients with mechanical circulatory support?
### Response:
| High h-FABP levels, indicating the presence of more severe myocardial damage, are associated with a poor prognosis in patients with LVAD, suggesting that an early cardiac injury marker could improve the prediction of clinical outcome. |
### Instruction:
Are tLR2-activated B cells phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis?
### Response:
| These results indicate that an elevated fraction of B cells display an activated/germinal center phenotype in those HIV+ subjects who go on to develop AIDS-NHL and suggest that TLR2-mediated activation may play a role in HIV infection-associated B-cell activation, potentially contributing to the genesis of AIDS-NHL. |
### Instruction:
Is diabetes mellitus with obesity a predictor of recurrence in patients with non-metastatic renal cell carcinoma?
### Response:
| Diabetes mellitus is a predictor of recurrence following surgery for non-metastatic renal cell carcinoma, especially in obese patients. |
### Instruction:
Do pretreatment CA 15-3 levels predict disease-free survival in patients with advanced epithelial ovarian cancer?
### Response:
| Although elevated in the majority of patients with advanced epithelial ovarian cancer, CA 15-3 levels are not predictive of survival. |
### Instruction:
Does s100P enhance the chemosensitivity of human gastric cancer cell lines?
### Response:
| S100P contributes to oxaliplatin chemosensitivity in gastric cell lines by increasing drug inflow. It might also be a novel independent prognostic factor in gastric cancer patients who receive adjuvant chemotherapy with oxaliplatin. |
### Instruction:
Does loss of fatty acid synthase inhibit the `` HER2-PI3K/Akt axis '' activity and malignant phenotype of Caco-2 cells?
### Response:
| A downregulation of FASN effectively inhibits the activity of "HER2-PI3K/Akt axis" and alters the malignant phenotype in colorectal cancer cells. |
### Instruction:
Do markers of good performance in mammography depend on number of annual readings?
### Response:
| Radiologists' determinants of performance are associated with annual reading volumes. Ability to recognize normal images is a discriminating factor in individuals with a high volume of mammographic readings. |
### Instruction:
Does interaction of NADPH oxidase 1 with Toll-like receptor 2 induce migration of smooth muscle cells?
### Response:
| These data suggest that Nox1 plays an important role in TLR2-mediated intracellular H2O2 generation, activation of matrix metalloprotease 2, and secretion of pro-inflammatory cytokines, which in turn stimulate MASMC migration and vascular remodelling. |
### Instruction:
Does total flavonoids of Mosla scabra leave attenuates lipopolysaccharide-induced acute lung injury via down-regulation of inflammatory signaling in mice?
### Response:
| These results showed MF significantly attenuate LPS-induced acute lung injury and production of inflammatory mediators via inhibiting MAPK and NF-κB activation, indicating it as a potential therapeutic agent for ALI. |
### Instruction:
Does pre-existing endothelial cell activation predict vasoplegia after mitral valve surgery?
### Response:
| Pre-existing endothelial cell activation, reflected by higher baseline von Willebrand Factor propeptide and sP-selectin levels, is a predisposing factor for post-cardiac surgery vasoplegia. The pre-existing endothelial cell activation may have resulted in desensibilization of endothelium in patients who develop vasople... |
### Instruction:
Do repeat intestinal resections increase the risk of recurrence of Crohn 's disease?
### Response:
| The limitation is the retrospective design of the study, with its potential selection bias. |
### Instruction:
Does notch activation promote endothelial survival through a PI3K-Slug axis?
### Response:
| Notch signaling leads to activation of parallel survival and apoptotic pathways in endothelial cells. The interaction of Notch with other signaling pathways plays an important contextual role in regulating endothelial viability. |
### Instruction:
Does brain correlate of short-term habituation to repetitive electrical noxious stimulation?
### Response:
| With this study, we identified central components associated with habituation to repetitive painful stimuli. The results suggest that an increase in tonic inhibitory activity in cortical pain processing areas is a major mechanism contributing to habituation to phasic noxious stimuli. Moreover, areas involved in descend... |
### Instruction:
Is extension MRI clinically useful in cervical myelopathy?
### Response:
| This is the first study to demonstrate added clinical value utilising extension MRI. In this cohort of difficult patients, when there was no T2 signal change in the cord, the presence of clinical myelopathy could only be predicted by utilising the data from extension imaging. |
### Instruction:
Does short-term aerobic exercise training increase postprandial pancreatic polypeptide but not peptide YY concentrations in obese individuals?
### Response:
| Short-term exercise training increases postprandial PP concentrations in obese individuals; however, PYY levels and glycemic control remain unaffected. Both PP and PYY show meal-induced increases at all meals, but PYY has a greater response at the first meal with reduced responses at subsequent meals. |
### Instruction:
Is intracranial hypotension a rare cause of orthostatic headache : a review of the etiology , treatment and prognosis of 13 cases?
### Response:
| Spontaneous intracranial hypotension should primarily be suspected in cases complaining about postural headache and contrast-enhanced cranial imaging should be performed. The presence of cranial nerve paralysis and pyramidal tract signs should b considered. Conservative treatments should be considered initially, howeve... |
### Instruction:
Is treatment failure and drug resistance more frequent in HIV-1 subtype D versus subtype A-infected Ugandans over a 10-year study period?
### Response:
| Higher rates of treatment failure among subtype D as compared with subtype A-infected Ugandans was analogous to the faster disease progression in subtype D-infected patients. The mechanism(s) by which drug resistance may emerge faster in subtype D HIV-1 may relate to higher replicative fitness and increased propensity ... |
### Instruction:
Is the increment in standardized uptake value determined using dual-phase 18F-FDG PET a promising prognostic factor in non-small-cell lung cancer?
### Response:
| SUVinc determined from dual-phase (18)F-FDG PET is a promising prognostic factor for NSCLC. It adds to the value of dual-phase (18)F-FDG PET. |
### Instruction:
Is the adherence of Trichomonas vaginalis to host ectocervical cells influenced by lactobacilli?
### Response:
| Lactobacilli can modulate adhesion of T vaginalis by significantly modifying the natural adhesive properties of various T vaginalis strains. This study highlights the importance of considering the role of the vaginal microbiota in the pathogenesis of trichomoniasis. |
### Instruction:
Does treatment result in the differential surgery of intradural extramedullary schwannoma of 110 cases?
### Response:
| In the case of appropriate surgical indications, the study suggests that hemilaminectomy+microscopic excision is advantageous in the removal of cervical schwannoma, and that laminectomy+microscopic excision is advantageous in the removal of thoracic schwannoma; lumbar intradural extramedullary schwannoma can be managed... |
### Instruction:
Are scalar-linear increases in perceived exertion dissociated from residual physiological responses during sprint-distance triathlon?
### Response:
| The maintenance of a scalar-linear increase in RPE by the brain remains the primary mechanism for pace regulation during both single and multi-modal endurance performance, with physiological responses being only indirectly related to this process. The apparent absence of any RPE 'resetting' between disciplines suggests... |
### Instruction:
Does mild hypothermia increase pulmonary anti-inflammatory response during protective mechanical ventilation in a piglet model of acute lung injury?
### Response:
| Mild hypothermia induced a local anti-inflammatory response in the lungs, without affecting lung function or coagulation, in this piglet model of ALI. The HT group had lower cardiac output without signs of global dysoxia, suggesting an adaptation to the decrease in oxygen uptake and delivery. Studies are needed to dete... |
### Instruction:
Does promoter hypermethylation contribute to the frequent suppression of the CDK10 gene in human nasopharyngeal carcinomas?
### Response:
| Our findings implicate that aberrant methylation of the CDK10 gene promoter occurs frequently in NPC, and that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of NPC patients. |
### Instruction:
Does glycogen synthase kinase 3 inhibitor attenuate endotoxin-induced liver injury?
### Response:
| ET attenuated LPS-induced acute liver injury through inhibiting GSK-3 functional activity and its downstream signaling. |
### Instruction:
Is diabetes mellitus associated with major morbidity following open abdominal aortic aneurysm repair?
### Response:
| Diabetes mellitus is not associated with significantly worse major outcomes following open, elective, infrarenal AAA repair. Diabetics, however, are more likely to develop superficial SSIs. |
### Instruction:
Does preinjury alcohol exposure attenuate the neuroinflammatory response to traumatic brain injury?
### Response:
| Alcohol treatment prior to TBI reduces the local neuroinflammatory response to injury. The decreased neurologic and inflammatory impact of TBI in acutely intoxicated patients may be responsible for improved clinical outcomes. |
### Instruction:
Does lipoprotein lipase gene polymorphism rs1059611 functionally influence serum lipid concentrations?
### Response:
| The results of our study demonstrated that rs1059611 was associated with HDL-C and TG concentrations in Chinese Han population and might have a functional effect on the transcription of LPL by differential binding of transcription factors. |
### Instruction:
Does undergraduate teaching in geriatric medicine using computer-aided learning improve student performance in examinations?
### Response:
| blended learning was associated with improvement in student examination performance, regardless of the setting or the methods adopted, and without increasing teaching time. Our findings support the use of CAL in teaching geriatric medicine, and this method has been adopted for teaching other topics in the undergraduate... |
### Instruction:
Is body mass index inversely associated with mortality in patients with peripheral vascular disease?
### Response:
| Obesity whether assessed by BMI or central fat deposition is associated with reduced risk of dying in patients with established PVD. Underweight is highly predictive of early mortality in patients with PVD. |
### Instruction:
Does radiation-induced myosin IIA expression stimulate collagen type I matrix reorganization?
### Response:
| Our data indicate the role of myosin IIA in col-I reorganization by irradiated BCC and reciprocal BCC death. |
### Instruction:
Is the miR-184 binding-site rs8126 T > C polymorphism in TNFAIP2 associated with risk of gastric cancer?
### Response:
| Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies. |
### Instruction:
Does alternative sigma factor over-expression enable heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli?
### Response:
| We have demonstrated a new mechanism for heterologous expression of the oxytetracycline polyketide biosynthetic pathway, where high-level pleiotropic sigma factors from the heterologous host directly and positively regulate transcription of the non-native biosynthetic gene cluster. Our bioinformatics analysis is consis... |
### Instruction:
Does cCL17/thymus and activation-regulated chemokine induce calcitonin gene-related peptide in human airway epithelial cells through CCR4?
### Response:
| CCL17-induced, CCR4-dependent release of CGRP by human airway epithelial cells represents a novel inflammatory pathway and a possible target in patients with asthma and allergic disease. |
### Instruction:
Does anthocyanin-rich juice affect gut-associated immunity in Fischer rats?
### Response:
| This in vivo study suggests that anthocyanins at physiological doses affect neither the systemic immune system, nor GALT, or MAT in healthy, unchallenged rats. |
### Instruction:
Does lipopolysaccharide induce the expression of an autocrine prolactin loop enhancing inflammatory response in monocytes?
### Response:
| Our results suggest the expression of a full-autocrine loop of PRL enhances the inflammatory response in activated monocytes. This response mediated by big PRL may contribute to the eradication of potential pathogens during innate immune response in monocytes but may also contribute to inflammatory disorders. |
### Instruction:
Does genome-wide association study identify new susceptibility loci for posttraumatic stress disorder?
### Response:
| This study identified TLL1 as a new susceptibility gene for PTSD. |
### Instruction:
Is scalloping a reliable endoscopic marker for celiac disease?
### Response:
| The results suggest that the diagnosis of CD is almost certain if isolated scalloping is observed during EGD done to rule out CD. Thus, attention to this finding may serve as an additional tool in the diagnosis of CD. |
### Instruction:
Does microchannel acoustophoresis impact survival or function of microglia , leukocytes or tumor cells?
### Response:
| We conclude that microchannel acoustophoresis can be used for effective continuous flow-based cell separation without affecting cell viability, proliferation, mitochondrial respiration or inflammatory status. |
### Instruction:
Is leishmaniasis sand fly vector density reduction less marked in destitute housing after insecticide thermal fogging?
### Response:
| Our results suggest the potential of insecticide application to control SF density and leishmaniasis transmission could depend on housing quality beyond insecticide efficiency. |
### Instruction:
Do nOTCH1 mutations influence survival in chronic lymphocytic leukemia patients?
### Response:
| Both NOTCH1 and TP53 mutations seem to be independent predictive markers for worse outcome in CLL-patients and this study emphasizes the contention that NOTCH1 mutations is a novel risk marker. |
### Instruction:
Do sERT-to-DAT ratios in early Parkinson 's disease correlate with the development of dyskinesias?
### Response:
| SERT-to-DAT ratios in early-stage untreated PD do not correlate with the future development of dyskinesias. However, our study does not exclude the possibility that SERT-to-DAT ratios increase with disease progression in patients that develop dyskinesias because of a slower rate of degeneration of the serotonergic syst... |
### Instruction:
Are pretherapeutic plasma pro- and anti- inflammatory mediators related to high risk of oral mucositis in pediatric patients with acute leukemia : a prospective cohort study?
### Response:
| The results imply that pretherapeutic high levels of inflammatory cytokines and low levels of pro-LL-37 in plasma might contribute to the high incidence of oral mucositis in patients with acute leukemia. These findings may add to our understanding of the predispositions to oral mucositis in children with malignancies. |
### Instruction:
Does iKKε knockout prevent high fat diet induced arterial atherosclerosis and NF-κB signaling in mice?
### Response:
| The knockout of IKKε prevented significant atherosclerosis lesions in the mouse aorta from in both wild-type and ApoE knockout mice fed a HFD, suggesting that IKKε may play a vital role in HFD-induced atherosclerosis and would be an important target for the treatment of atherosclerosis. |
### Instruction:
Do rapid on-site cytologic examination of 1500 breast lesions using the modified Shorr 's stain?
### Response:
| Our modified Shorr's staining protocol was useful to reduce the time for the diagnosis and treatment planning of breast lesions suspected of being breast cancer. It is beneficial for both the patients and clinicians. |
### Instruction:
Is dysfunction of the PI3K-Akt-GSK-3 pathway a common feature in cell culture and in vivo models of prion disease?
### Response:
| Our findings in cell culture and in vivo models of prion disease demonstrate marked alterations to the PI3K/Akt/GSK-3 pathway and suggest that two additional pathways contribute to PrP-induced neurotoxicity as responsible of JNK and caspase 12 activation. |
### Instruction:
Do cooler temperatures destabilize RNA interference and increase susceptibility of disease vector mosquitoes to viral infection?
### Response:
| This data suggest that microclimates, such as those present in mosquito breeding sites, as well as more general climactic variables may influence the dynamics of mosquito-borne viral diseases by affecting the antiviral immunity of disease vectors. |
### Instruction:
Does s100B promote glioma growth through chemoattraction of myeloid-derived macrophages?
### Response:
| These observations suggest that S100B promotes glioma growth by TAM chemoattraction through upregulation of CCL2 and introduces the potential utility of S100B inhibitors for glioma therapy. |
### Instruction:
Do nanoparticles engineered with rituximab and loaded with Nutlin-3 show promising therapeutic activity in B-leukemic xenografts?
### Response:
| Our data show for the first time the potential antileukemic activity of rituximab-engineered Nutlin-3-loaded NPs in xenograft SCID mice. |
### Instruction:
Is σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity correlated to body temperature modulation?
### Response:
| The ability of σ receptor antagonists to mitigate METH-induced hyperthermia may contribute to its neuroprotective actions. |
### Instruction:
Does pharmacological reduction of mucosal but not neuronal serotonin oppose inflammation in mouse intestine?
### Response:
| Observations suggest that that peripheral TPH inhibitors uncouple the positive linkage of enterochromaffin cell-derived 5-HT to intestinal inflammation. Because peripheral TPH inhibitors evidently do not enter the murine ENS, they lack deleterious effects on constitutive intestinal motility in mice. |
### Instruction:
Do atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase?
### Response:
| Atorvastatin facilitates survival of implanted MSCs, improves function and morphology of infarcted hearts, mediated by activation of eNOS and alleviated by NOS inhibitor. The data reveal the cellular and molecular mechanism for anti-AMI therapy with a combination of statin and stem cells. |
### Instruction:
Does comparative exploration of whole-body MR through locally rigid transform?
### Response:
| We demonstrated how our method significantly facilitates examination of whole-body MR datasets in follow-up studies by enabling the rapid interactive matching of regions of interest and by the explicit visualization of change. |
### Instruction:
Does pinocembrin protect rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids?
### Response:
| Inhibiting sEH and then increasing the potency of EETs may be one of the mechanisms through which pinocembrin provides cerebral protection. |
### Instruction:
Does wuling san ameliorate urate under-excretion and renal dysfunction in hyperuricemic mice?
### Response:
| Compared to the hyperuricemia control group, Wuling San significantly reduced serum uric acid and creatinine levels, increased 24 h urate and creatinine excretion, and FEUA in hyperuricemic mice, exhibiting its ability to enhance urate excretion and improve kidney function. Wuling San was found to down-regulate mRNA an... |
### Instruction:
Does euphorbia kansui roots induced-diarrhea in mice correlate with inflammatory response?
### Response:
| The results showed that the extract of E. KS acted on the intestinal smooth muscle with propulsion of feces involving the irritation of the intestines with acute inflammatory reactions. |
### Instruction:
Does sorafenib act synergistically in combination with radiotherapy without causing intestinal damage in colorectal cancer?
### Response:
| We provide a scientific rationale for the use of sorafenib in combination with radiotherapy in colorectal cancer. |
### Instruction:
Does urinary albumin excretion at follow-up predict cardiovascular outcomes in subjects with resistant hypertension?
### Response:
| In RH patients, the inability to microalbuminuria regression, either due to persistence or new appearance, independently predicts CVD. |
### Instruction:
Does iFN-γ inhibit liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice?
### Response:
| IFN-γ inhibits LPC expansion via the direct inhibition of LPC proliferation and indirect attenuation of liver fibrosis in the DDC model, but it may also enhance LPC expansion via the promotion of inflammation in the CDE model; thereby playing dual roles in regulating LPC proliferation in vivo. |
### Instruction:
Does syringic acid from Tamarix aucheriana possess antimitogenic and chemo-sensitizing activities in human colorectal cancer cells?
### Response:
| SA exerted its chemotherapeutic and chemo-sensitizing effects through an array of mechanisms including cell-cycle arrest, apoptosis induction, inhibition of cell proliferation, cell migration, angiogenesis, NFκB DNA-binding and proteasome activities. |
### Instruction:
Is thromboelastometric maximum clot firmness in platelet-free plasma influenced by the assay used?
### Response:
| We speculate that FIBTEM and FIBTEM PLUS may contain stabilizing agents that enhance fibrin polymerization whereas FFTEG might contain less tissue factor than the ROTEM assays. |
### Instruction:
Is gP73 down-regulated in gastric cancer and associated with tumor differentiation?
### Response:
| GP73 was normally expressed in non-tumorous gastric mucosa and down-regulated in gastric cancer. Its expression in gastric cancer was correlated with tumor differentiation. |
### Instruction:
Are metabolic disease and participant age independent predictors of response to pulmonary rehabilitation?
### Response:
| Identifying responders in exercise capacity following PR remains difficult, with only age and participants with metabolic disease identified as independent predictors. |
### Instruction:
Does late administration of a specific COX-2 inhibitor treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure?
### Response:
| Late introduction of specific COX-2 inhibitor (Meloxicam) did not treat and was not able to prevent the progression of tumoral lesions induced by duodenogastric reflux in the rat stomachs. |
### Instruction:
Are dioxin-like compounds associated with bone strength measured by ultrasonography in Inuit women from Nunavik ( Canada ) : results of a cross-sectional study?
### Response:
| Our results do not support a relation between exposure to DLCs and bone strength measured by ultrasonography in Inuit women of Nunavik. |
### Instruction:
Are subepicardial action potential characteristics a function of depth and activation sequence in isolated rabbit hearts?
### Response:
| Decreased electrotonic load at the epicardial surface results in more rapid AP upstrokes and higher conduction velocities compared with the bulk myocardium. Combined effects of tissue depth and pacing rate on AP rise time reduce conduction safety and myocardial excitability within the ventricular wall. |
### Instruction:
Is upregulation of the TPX2 gene associated with enhanced tumor malignance of esophageal squamous cell carcinoma?
### Response:
| Overexpression of TPX2 may be risk factor of lymph node in esophageal carcinoma, and maybe a potential biomarker for early diagnosis and prognosis of esophageal squamous cell carcinoma. |
### Instruction:
Is cABG mortality influenced by prior PCI in low risk patients?
### Response:
| In this study involving low risk patients, a PCI prior to CABG did not increase morbidity or mortality. |
### Instruction:
Does s100P predict prognosis and drug resistance in gastric cancer?
### Response:
| The expression of S100P in human gastric cancer tissues was upregulated in comparison with normal controls. By establishing an association between S100P expression and shortened OS, increase in proliferation and drug resistance, this study indicates that S100P may be a useful prognostic marker for gastric cancer patien... |
### Instruction:
Do bending moments of zirconia and titanium implant abutments supporting all-ceramic crowns after aging?
### Response:
| The differently connected zirconia abutments exhibited similar bending moments with the exception of one group. Hence, the type of connection only had a minor effect on the stability of restored zirconia abutments. In general, restored titanium abutments exhibited the highest bending moments. |
### Instruction:
Is serum prostate-specific antigen ( PSA ) concentration positively associated with rate of disease reclassification on subsequent active surveillance prostate biopsy in men with low PSA density?
### Response:
| Risk for biopsy reclassification increased non-linearly across PSA concentration in men with low PSAD, whereby no obvious clinically meaningful threshold could be identified. This information could be incorporated into decision-making for AS. However, longer follow-up times are needed to warrant final conclusions. |
### Instruction:
Does [ Monoclonal antibody against laminin receptor 1 inhibit the pulmonary fibrosis induced by bleomycin in rats ]?
### Response:
| LAMR1 mAb can evidently alleviate pulmonary fibrosis induced by bleomycin in rats. |
### Instruction:
Does novel membrane frizzled-related protein gene mutation as cause of posterior microphthalmia resulting in high hyperopia with macular fold?
### Response:
| These are the youngest nanophthalmos patients in the literature identified with severe loss of MFRP function, showing already the known structural abnormalities for this disease. Adult patients affected by homozygous or compound heterozygous MFRP mutations generally show signs of retinal dystrophy, with ERG disturbance... |
### Instruction:
Does preoperative angiotensin system inhibitor use attenuate heparin-induced hypotension in patients undergoing cardiac surgery?
### Response:
| This prospective clinical study indicated that preoperative ASI therapy until the day before surgery may attenuate heparin-induced hypotension. Definitive mechanistic insight requires further clinical study. |
### Instruction:
Are low levels of high-density lipoproteins associated with acute kidney injury following revascularization for chronic limb ischemia?
### Response:
| AKI following revascularization is not uncommon (12.0%), and lower concentrations of HDL and serum albumin are associated with increased odds of postoperative AKI. There was also a trend of higher prevalence of AKI among those with pre-existing CKD. |
### Instruction:
Does silent information regulator 1 protect the brain against cerebral ischemic damage?
### Response:
| These results support the idea that SIRT1 plays an important role in neuroprotection against brain ischemia by deacetylation and subsequent inhibition of p53-induced and nuclear factor κB-induced inflammatory and apoptotic pathways. |
### Instruction:
Does rounding behavior in the reporting of headache frequency complicate headache chronification research?
### Response:
| Because of the coarsening induced by rounding, caution should be used when distinguishing between episodic and chronic headache sufferers using self-reported estimates of headache frequency. Unreliability in frequency estimates is of particular concern among individuals with high-frequency (chronic) headache. Employing... |
### Instruction:
Is analysis of risk factors for late presentation in a cohort of HIV-infected patients in Dresden : positive serology for syphilis in MSM a determinant for earlier HIV diagnosis?
### Response:
| A positive syphilis screening test seems to be a determinant for lower risk of late presentation to HIV care and diagnosis in MSM. The presence and awareness of sexually transmitted infections (STIs) such as syphilis may lead to earlier utilisation of HIV health care and, thus, promote earlier HIV diagnosis. HIV preven... |
### Instruction:
Are statins associated with reduced risk of gastric cancer : a meta-analysis?
### Response:
| A meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer. |
### Instruction:
Does dietary uptake of Wedelia chinensis extract attenuate dextran sulfate sodium-induced colitis in mice?
### Response:
| Together, our findings suggest that specific extracts of W. chinensis have nutritional potential for future development into nutraceuticals or dietary supplements for treatment of inflammatory bowel disease. |
### Instruction:
Do genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development?
### Response:
| Our data suggest a relatively weak but functionally relevant role for vitamin D in the prevention of HCV-related hepatocarcinogenesis. |
### Instruction:
Do monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats?
### Response:
| Our findings support the hypothesis that epitope-specific GAD65Ab induce cerebellar dysfunction impairing motor and procedural abilities. This is the first demonstration of a critical role of cerebellar nuclei GAD65 enzyme in procedural spatial functions. |
### Instruction:
Does cancer associated E17K mutation cause rapid conformational drift in AKT1 pleckstrin homology ( PH ) domain?
### Response:
| The overall result suggested that, although the mutation did not induce any stability loss in structure, the associated pathological consequences might have occurred due to the rapid conformational drifts observed in the mutant AKT1 PH domain. |
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