question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does targeting CD133 in an in vivo ovarian cancer model reduce ovarian cancer progression?
### Response:
| Directly targeting CSC that are a major cause of drug resistant tumor relapse with an anti-CD133 targeted toxin shows promise for ovarian cancer therapy. |
### Instruction:
Does liposomal temocene ( m-THPPo ) photodynamic treatment induce cell death by mitochondria-independent apoptosis?
### Response:
| Photodynamic treatment with liposomal m-THPPo leads to a significant percentage of apoptotic morphology of HeLa cells. The activation of caspase-2, without the relocalization of cytochrome c, indicates a mitochondrial-independent apoptotic mechanism. |
### Instruction:
Is aggregate plaque volume by coronary computed tomography angiography superior and incremental to luminal narrowing for diagnosis of ischemic lesions of intermediate stenosis severity?
### Response:
| Compared with diameter stenosis, area stenosis, MLD, and MLA, %APV by coronary CTA improves identification, discrimination, and reclassification of ischemic lesions of intermediate stenosis severity. |
### Instruction:
Does glasgow prognostic score predict therapeutic outcome after pancreaticoduodenectomy for carcinoma of the ampulla of vater?
### Response:
| The GPS in patients with carcinoma of the ampulla of Vater is an independent prognostic predictor after elective pancreaticoduodenectomy. |
### Instruction:
Does early treatment with inhaled antibiotics postpone next occurrence of Achromobacter in cystic fibrosis?
### Response:
| Early treatment with inhaled antibiotics may prevent or postpone chronic infection with Achromobacter in CF patients. |
### Instruction:
Does single Treatment with 100-Microsecond Alexandrite Laser clear Selected Acquired Melanocytic Nevi in Type IV Asian Facial Skin?
### Response:
| The μsAL is an effective modality for the removal of small facial AMNs. |
### Instruction:
Does an investigation of culturally competent terminology in healthcare policy found ambiguity and lack of definition?
### Response:
| Cultural competence within health services has been identified as an important factor that can improve the health outcomes for families from marginalised communities. However, inconsistency in definitions, understanding and implementation of cultural competence in health practice makes it difficult to implement care us... |
### Instruction:
Is pulmonary large cell carcinoma lacking squamous differentiation clinicopathologically indistinguishable from solid-subtype adenocarcinoma?
### Response:
| Other than a paucity of intracellular mucin, LCC lacking squamous or neuroendocrine differentiation is indistinguishable from solid-subtype ADC. We propose the reclassification of these tumors as mucin-poor solid adenocarcinomas. |
### Instruction:
Do deformable anatomic templates improve analysis of gliomas with minimal mass effect in eloquent areas?
### Response:
| This is proof of concept that DAT can improve the analysis of diffuse gliomas of any grade by efficiently alerting the surgeon to the possibility of eloquent area invasion. The technique is especially helpful in diffuse glioma because these tumors tend to infiltrate rather than displace eloquent structures. DAT is limi... |
### Instruction:
Do postoperative complications influence prognosis and recurrence patterns in periampullary cancer?
### Response:
| Postoperative complications affect prognosis and recurrence patterns in patients with periampullary cancer after PD. |
### Instruction:
Does the prognostic value of microRNAs vary with patient race/ethnicity and stage of colorectal cancer?
### Response:
| These preliminary findings suggest that the prognostic value of miRNAs in colorectal cancers varies with patient race/ethnicity and stage of disease. |
### Instruction:
Does deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affect integrative visuomotor capabilities?
### Response:
| Impaired eye-tracking skills in 4-year-old children exposed to methadone or buprenorphine and tobacco prenatally could inhibit the development of some cognitive functions in later life. |
### Instruction:
Does chronological age affect the permeation of fentanyl through human skin in vitro?
### Response:
| We demonstrate that fentanyl permeates the skin of young individuals in greater amounts and at a higher absorption rate than in middle-aged and old individuals in vitro. |
### Instruction:
Does a single intraperitoneal injection of ketamine affect spatial working , reference memory or neurodegeneration in adult mice : An animal study?
### Response:
| These data indicate that a single intraperitoneal injection of ketamine at subanaesthetic and anaesthetic doses does not impair working memory, reference memory or neurodegeneration in adult mice, but an intermediate dose of ketamine produces transitory hyperlocomotion. |
### Instruction:
Do different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis?
### Response:
| The markedly variable conversion rates by different pretreatment conditions complicated the quality control of this herb, mainly due to the high amount of endogenous enzymes of S. baicalensis. Optimal pretreatment conditions observed in this study could be used obtain the highest level of desired constituents to achiev... |
### Instruction:
Is pronecrotic mixed lineage kinase domain-like protein expression a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma?
### Response:
| Low expression of MLKL is associated with decreased OS in patients with resected PAC and decreased RFS and OS in the subset of patients with resected PAC who receive adjuvant chemotherapy. The use of this biomarker in patients with PAC may provide important prognostic information. |
### Instruction:
Are serum pepsinogens and Helicobacter pylori associated with esophageal squamous cell carcinoma in a high-risk area in China?
### Response:
| In this prospective study, neither H pylori infection nor abnormal pepsinogen status had a predictive role for the development of esophageal squamous cell carcinoma in the rural population of China. |
### Instruction:
Does the valosin-containing protein promote cardiac survival through the inducible isoform of nitric oxide synthase?
### Response:
| We conclude that the Akt substrate, VCP, mediates the increased expression of iNOS downstream from Hsp22 through an NF-κB-dependent mechanism. |
### Instruction:
Does education protect against cognitive changes associated with multiple sclerosis?
### Response:
| These findings provide evidence that higher education could be protective against MS-associated cognitive deficits and that high speed PASAT versions are more suitable for identifying compensatory capacities compared to low speed PASAT versions. |
### Instruction:
Do occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma?
### Response:
| The occurrence of stitch abscesses was related to age, liver dysfunction, and/or the presence of allergies. When diagnosing stitch abscess, the occurrence of multiple stitch abscesses is important. |
### Instruction:
Does downregulation of KLF8 expression by shRNA induce inhibition of cell proliferation in CAL27 human oral cancer cells?
### Response:
| These results strongly suggest that KLF8 is essential for growth of CAL 27 cancer cells. A better understanding of KLF8 function and processing may provide novel insights into the clinical therapy of oral cancer. |
### Instruction:
Is a common polymorphic allele of the LH beta-subunit gene associated with higher exogenous FSH consumption during controlled ovarian stimulation for assisted reproductive technology?
### Response:
| These results confirm that carriers exhibit hypo-sensitivity to exogenous FSH during COS, documenting that the frequency of v-betaLH in Denmark is similar to a number of European countries. |
### Instruction:
Is microRNA-491 involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition?
### Response:
| Our results suggest that miR-491 is involved in metastasis of HCC by blocking EMT and decreasing MMP-9 levels, which may provide a new clue for preventing tumour metastasis of HCC. |
### Instruction:
Do cD11a polymorphisms regulate TH2 cell homing and TH2-related disease?
### Response:
| Polymorphisms in CD11a critically influence TH2 cell homing and diverse TH2-dependent immunopathologic states in mice and potentially influence the expression of human allergic disease. |
### Instruction:
Is early remission associated with improved survival in patients with inflammatory polyarthritis : results from the Norfolk Arthritis Register?
### Response:
| Early and sustained remission is associated with decreased all-cause mortality in patients with IP. This result supports clinical remission as the target in the management of IP. |
### Instruction:
Does an RNA aptamer provide a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein?
### Response:
| This paper includes the first characterisation of the effects of an E7 RNA aptamer in a cell line derived from a cervical carcinoma. Transfection of cells with A2 was correlated with the loss of E7 and the induction of apoptosis. Aptamers specific for a number of cellular and viral proteins have been documented previou... |
### Instruction:
Does active suppression induced by repetitive self-epitopes protect against EAE development?
### Response:
| This study strongly supports an immunosuppressive role of repeat auto-antigens to control the development of EAE with potential applications in vaccination and antigen specific treatment of autoimmune diseases. |
### Instruction:
Is length of psychiatric hospitalization correlated with CYP2D6 functional status in inpatients with major depressive disorder?
### Response:
| CYP2D6 enzymatic functional status significantly affected length of hospital stay, perhaps due to reduced efficacy or increased side effects of the medications metabolized by the CYP2D6 isoenzyme. Functional scoring of CYP2D6 alleles may have a substantial impact on the quality of care, patient satisfaction and the eco... |
### Instruction:
Does benzylpenicillin inhibit the renal excretion of acyclovir by OAT1 and OAT3?
### Response:
| It indicates that acyclovir is a substrate for OAT1 and OAT3. PCG inhibits the renal excretion of acyclovir by inhibiting renal transporters OAT1 and OAT3 in vivo and in vitro. These results suggest important information for DDI between PCG and acyclovir in kidney. |
### Instruction:
Does luminal melatonin stimulate pancreatic enzyme secretion via activation of serotonin-dependent nerves?
### Response:
| Stimulation of pancreatic exocrine function caused by intraluminal administration of melatonin, or L-tryptophan is modified, at least in part, by serotoninergic mechanisms and vagal nerves. |
### Instruction:
Does quadrupedal head position enhance recovery from chronic maxillary sinusitis?
### Response:
| The improvements of QoL scores and CT scores were significantly better in the quadrupedal head position group than that in the non-quadrupedal head position group. Quadrupedal head position can be valuable adjuvant therapy for patients with CMS. |
### Instruction:
Do front-of-package references to fiber on foods in Canadian supermarkets highlight the need for increased nutrition knowledge among consumers?
### Response:
| Consumers may be faced with challenges in seeking out healthful sources of fiber in the grocery store, given the complexity of existing front-of-package nutrition-related marketing and limited references to fiber in some categories. This work suggests that current nutrition-related marketing cannot function as a substi... |
### Instruction:
Does inhibition of c-Jun N-terminal kinase activity enhance vestibular schwannoma cell sensitivity to gamma irradiation?
### Response:
| Inhibition of JNK signaling decreases histone 2AX phosphorylation and increases ROS and apoptosis in VS cells after gamma irradiation. These results raise the possibility of using JNK inhibitors to increase the effectiveness of radiosurgery for treatment of VSs. |
### Instruction:
Is methylation of the HACE1 gene frequently detected in hepatocellular carcinoma?
### Response:
| All stages of HCCs presented HACE1 methylation, indicating that the HACE1 gene has been methylated from the early stages of HCCs. |
### Instruction:
Does acute inflammation in young children inhibit C-type natriuretic peptide?
### Response:
| Acute inflammation in young children potently reduces CNP production, which needs to be considered when screening for growth disorders. Our data raise the possibility that the adverse effects of inflammatory cytokines on skeletal growth may be mediated in part by reduced CNP. |
### Instruction:
Are postprandial adiponectin levels associated with improvements in postprandial triglycerides after Roux-en-Y gastric bypass in type 2 diabetic patients?
### Response:
| The adiponectin levels may be involved in the mechanism responsible for high TG levels in obese and diabetic patients. These abnormalities can be reversed by RYGB. |
### Instruction:
Do the genomic architecture and association genetics of adaptive characters using a candidate SNP approach in boreal black spruce?
### Response:
| The sharing of genomic regions and significant SNPs between budset timing and tree height indicates pleiotropic effects. Significant QTLs and SNPs differed quite greatly among years, suggesting that different sets of genes for the same characters are involved at different stages in the tree's life history. The function... |
### Instruction:
Is ventricular assist device implant in the elderly associated with increased , but respectable risk : a multi-institutional study?
### Response:
| Multi-institutional analysis revealed advanced age as a predictor of increased mortality after CF LVAD implantation. Careful patient selection is critical in the elderly to optimize long-term outcomes after CF LVAD implantation. |
### Instruction:
Does albumin administration protect against bilirubin-induced auditory brainstem dysfunction in Gunn rat pups?
### Response:
| Albumin treatment is neuroprotective in acute hyperbilirubinemia in Gunn rat pups. Our present results underline the importance of functional diagnostic test of neurotoxicity above biochemical concentrations. |
### Instruction:
Does fractional carbon dioxide laser improve nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate?
### Response:
| Fractional laser pretreatment increases the fluorescence and clinical effectiveness of ALA-PDT for the treatment of nBCC. |
### Instruction:
Do vitamin D-related host genetic variants alter HIV disease progression in children?
### Response:
| Vitamin D-related host genetic variants that alter the availability and activity of vitamin D are associated with risk of HIV disease progression in children and may vary by age and race. |
### Instruction:
Is electrical storm in idiopathic ventricular fibrillation associated with early repolarization?
### Response:
| The VF storms in the IVF patients were highly associated with J waves that showed augmentation prior to the VF onset. Isoproterenol was effective in controlling VF and attenuated the J waves, which diminished to below the diagnostic level during follow-up. VF recurred in patients followed up without antiarrhythmic agen... |
### Instruction:
Does hypoxia influence stem cell-like properties in multidrug resistant K562 leukemic cells?
### Response:
| Hypoxia plays an important role in enhancing the stem cell-like properties and to induce multidrug resistance of leukemia cells. The activation of the TGF-β/Smad2 signaling pathway may be involved in the regulation of this pathophysiological process. |
### Instruction:
Does [ A de novo mutation of P gene cause oculocutaneous albinism type 2 with prenatal diagnosis ]?
### Response:
| A maternally inherited de novo mutation c.1327G>A has been identified in the patient. In order to detect de novo mutations, full sequence analysis is necessary. |
### Instruction:
Does mitochondria protection with ginkgolide B-loaded polymeric nanocapsules prevent diethylnitrosamine-induced hepatocarcinoma in rats?
### Response:
| Positive zeta-potential on N2GB surface might have offered higher hepatic accumulation of GB, especially at the electron-dense organelle mitochondria. Mitochondria protection against DEN-induced oxidative damage ensured HCC prevention. |
### Instruction:
Does dual-energy subtraction radiography improve laryngeal delineation in patients with moderate to severe cervical spondylosis?
### Response:
| DES provides better delineation of the laryngeal anatomy than conventional FPD radiography predominantly in patients with moderate-severe cervical spondylosis. |
### Instruction:
Do pericytes derived from adipose-derived stem cells protect against retinal vasculopathy?
### Response:
| ASC-derived pericytes can integrate with retinal vasculature, adopting both pericyte morphology and marker expression, and provide functional vascular protection in multiple murine models of retinal vasculopathy. The pericyte phenotype demonstrated by ASCs is enhanced with TGF-β1 treatment, as seen with native retinal ... |
### Instruction:
Does right atrial to left atrial area ratio on early echocardiography predict long-term survival after acute pulmonary embolism?
### Response:
| A RA/LA Ratio >1.0 at presentation with acute PE was associated with a three-fold increased risk of long-term mortality. The RA/LA ratio on presentation with an acute PE is a simple, novel predictor of long-term survival. |
### Instruction:
Does sleep deprivation accelerate delay-related loss of visual short-term memories without affecting precision?
### Response:
| Visual short-term memory is compromised during sleep deprivation, an effect compounded by delay. However, when memories are retrieved, they tend to be intact. |
### Instruction:
Does the genome sequencing of an albino Western lowland gorilla reveal inbreeding in the wild?
### Response:
| In this study we demonstrate how the use of whole genome sequencing can be extended to link genotype and phenotype in non-model organisms and it can be a powerful tool in conservation genetics (e.g., inbreeding and genetic diversity) with the expected decrease in sequencing cost. |
### Instruction:
Is microRNA-mediated regulation of target genes in several brain regions correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression?
### Response:
| The combinatorial analysis of miRNA-mediated regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can help reveal the brain region-specific contributions of miRNAs to brain function and development. |
### Instruction:
Is vaccination against seasonal influenza effective in Japanese patients with rheumatoid arthritis enrolled in a large observational cohort?
### Response:
| Influenza vaccination was effective in patients with RA regardless of disease activity or treatment. |
### Instruction:
Are low graft function and ongoing hyperparathyroidism closely related to post-transplantation osteoporosis?
### Response:
| Changes in bone density after RT were affected by graft function. The rapid loss of bone mineral density emphasizes the need for prevention started in the early posttransplant period. BMD measurements provided a guide for treatment and for subsequent evaluation. |
### Instruction:
Is the adiponectin gene single-nucleotide polymorphism rs1501299 associated with hepatocellular carcinoma risk?
### Response:
| This is the first report, demonstrating an association of ADIPOQ polymorphisms with HCC risk. Our results implicate the ADIPOQ SNP rs1501299 as a susceptibility locus for HCC. |
### Instruction:
Is the immunohistochemical expression of c-Met an independent predictor of survival in patients with glioblastoma multiforme?
### Response:
| Our findings suggest that c-Met immunohistochemical expression is an independent predictor of outcomes in patients with GBM treated by standard of care. |
### Instruction:
Does arterial spin-labeled perfusion imaging reflect vascular density in nonfunctioning pituitary macroadenomas?
### Response:
| Arterial spin-labeled perfusion imaging reflects the vascular density of nonfunctioning pituitary macroadenomas, which may be useful in the preoperative prediction of intra- and postoperative tumor hemorrhage. |
### Instruction:
Does normal-appearing white matter permeability distinguish poor cognitive performance in processing speed and working memory?
### Response:
| Significant normal-appearing white matter relative recirculation reduction exists in cognitively impaired patients with secondary-progressive MS, localizing to the domains of processing speed and working memory. |
### Instruction:
Does ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveal a dynamic inflammatory penumbra after strokes?
### Response:
| MPIOs-αVCAM-1-enhanced imaging seems to be promising in the detection of individuals presenting with severe cerebrovascular responses after stroke, which could therefore benefit from anti-inflammatory treatments. |
### Instruction:
Does lipoprotein receptor-related protein-6 protect the brain from ischemic injury?
### Response:
| LRP6 activates an endogenous neuroprotective pathway that acts independently of β-catenin by controlling GSK-3β activity and preventing its deleterious mitochondrial and proinflammatory effects. The findings raise the possibility that emerging treatment strategies for diseases attributable to LRP6 loss-of-function muta... |
### Instruction:
Is secretory clusterin ( sCLU ) overexpression associated with resistance to preoperative neoadjuvant chemotherapy in primary breast cancer?
### Response:
| We, therefore, suggested sCLU expression may be a useful marker for predicting response to preoperative chemotherapy and clinical outcome in patients with locally advanced breast cancer. |
### Instruction:
Does lipoic acid prevent hepatic and intestinal damage induced by obstruction of the common bile duct in rats?
### Response:
| Our results showed the protective potential of LA with liver and intestine damage. Despite improvements in operative technique and the development of potent, broad-spectrum antibiotics, biliary tract surgery in patients with obstructive jaundice is still associated with high morbidity and mortality rates In summary, ou... |
### Instruction:
Are prehospital ECG signs of acute coronary occlusion associated with reduced one-year mortality?
### Response:
| Among patients with a suspected ACS, prehospital ECG-signs indicating an acute coronary occlusion were not only a predictor for direct admission to acute coronary care but also a predictor for increased survival. To improve future outcome in acute ischemic heart diseases we must find and treat not only the STEMI's but ... |
### Instruction:
Does constitutional varus affect joint line orientation in the coronal plane?
### Response:
| Constitutional varus does not affect joint line orientation. Advanced medial arthritis causes divergence of the joint line from parallel to the floor. These findings influence decision-making for osteotomy and alignment in total knee arthroplasty. |
### Instruction:
Do apoptotic and proliferative defects characterize ocular development in a microphthalmic BMP model?
### Response:
| These data support a model whereby the gdf6a(-/-)-induced microphthalmia is based on early regulation of retinal progenitor cell number, and later by regulation of proliferation in the ciliary marginal zone. Foxi genes represent downstream effectors of Gdf6a function in the CMZ required for eye size determination. |
### Instruction:
Does telmisartan protect against microvascular dysfunction during myocardial ischemia/reperfusion injury by activation of peroxisome proliferator-activated receptor γ?
### Response:
| Except for the typical effects of angiotensin II-receptor blocker, telmisartan improved microvascular dysfunction during myocardial I/R injury via the PPARG pathway. |
### Instruction:
Does glucosamine alleviate scopolamine induced spatial learning and memory deficits in rats?
### Response:
| The results of this study showed that the glucosamine can inhibit scopolamine-induced impairments of spatial learning and memory in rats. Glucosamine might offer a promise in either the prevention or the treatment of neurodegenerative diseases such as Alzheimer's disease. |
### Instruction:
Does no strong temporal relationship between obesity and multisite pain -- result from a population-based 20-year follow-up study?
### Response:
| Being overweight or obese was associated with future multisite pain, although the magnitude of the association was small and the dose-response relationship observed in cross-sectional analyses disappeared in prospective analyses. There was less evidence that having multisite pain was a predictor of future overweight/ob... |
### Instruction:
Is stress hyperglycemia in acute ST-segment elevation myocardial infarction a marker of left ventricular remodeling?
### Response:
| SH is associated with high in-hospital mortality risk and it could be marker of LV remodeling (significant increase of EDV during one year). |
### Instruction:
Does short outpatient pulmonary rehabilitation programme reduce readmission following a hospitalization for an exacerbation of chronic obstructive pulmonary disease?
### Response:
| A short course of PR showed improvements in exercise capacity and health status in patients who have had an acute exacerbation of COPD. The number of readmissions was also significantly lower in the year following PR. |
### Instruction:
Does delayed motor response correlate with striatal degeneration in Parkinson 's disease?
### Response:
| We conclude that reaction- and movement-time is related to the dopaminergic nigrostriatal degeneration in untreated parkinsonian subjects. |
### Instruction:
Does active immunization of combined beta1-adrenoceptor and M2-muscarinic receptor peptides induce cardiac hypertrophy in rabbits?
### Response:
| Our results showed the coexistence of both anti-beta1-adrenoceptor and anti-M2-muscarinic receptor autoantibodies in the sera has pathophysiological importance, shown by their ability to induce cardiac hypertrophy in rabbits. |
### Instruction:
Does association with oleic acid vesicles enhance manganese III mesoporphyrin absorption and biliary elimination in rats?
### Response:
| Association with OA vesicles may enhance the rate of MnMeso absorption and biliary excretion while promoting the extent of liver accumulation of MnMeso in rats. This strategy may provide a means to provide safe and effective use of MnMeso as an MR contrast medium. |
### Instruction:
Is forearm reactive hyperaemia mediated by nitric oxide in healthy volunteers?
### Response:
| Nitric oxide production does not make a significant contribution to the vasodilatation associated with reactive hyperaemia in the human forearm. |
### Instruction:
Does cOMT inhibition with tolcapone affect carbidopa pharmacokinetics in parkinsonian patients in levodopa/carbidopa ( Sinemet )?
### Response:
| These results indicate that tolcapone does not affect carbidopa elimination and that no interaction of any clinical relevance occurs between tolcapone and carbidopa. |
### Instruction:
Does iris color alone predict susceptibility to the oculocardiac reflex in strabismus surgery?
### Response:
| The prediction of oculocardiac reflex propensity remains elusive. |
### Instruction:
Does acetylcholine intramuscular injection improve results of inferior oblique myectomy?
### Response:
| Our experience with injection of acetylcholine to the myectomized inferior oblique shows that it can, by stimulating contraction, enhance withdrawal and recession of the disinserted myectomized muscle and thereby eliminate undesirable reattachment near the original insertion. The end result is a lower incidence of pers... |
### Instruction:
Does gonadotropin-releasing hormone increase CD4 T-lymphocyte numbers in an animal model of immunodeficiency?
### Response:
| GnRH shows potential utility as an immunostimulatory agent in immunodeficient states manifesting diminished numbers of immunocompetent CD4(+) T lymphocytes. |
### Instruction:
Do peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture?
### Response:
| Our data suggest that these peptides or their derivatives may be useful as therapeutic modulators of LFA-1/ICAM-1 interaction during organ transplants. |
### Instruction:
Is preoperative localization of insulinomas necessary?
### Response:
| The diagnosis of an insulinoma does not require extensive localization studies before operation. The combination of surgical exploration and intraoperative ultrasonography identified more than 90% of insulinomas. When technically feasible, enudeation is curative and can be accomplished with low morbidity. |
### Instruction:
Are group II and IV phospholipase A ( 2 ) produced in human pancreatic cancer cells and influence prognosis?
### Response:
| These data suggest that PLA(2)-II and PLA(2)-IV are upregulated in human pancreatic cancer, and that upregulation of PLA(2)-II in pancreatic cancer covariates negatively with cancer cell growth. |
### Instruction:
Is variceal pressure a strong predictor of variceal haemorrhage in patients with cirrhosis as well as in patients with non-cirrhotic portal hypertension?
### Response:
| Variceal pressure is a major predictor of variceal bleeding in patients with cirrhosis as well as in patients with non-cirrhotic portal hypertension. The risk of bleeding in non-cirrhotics is less than in cirrhotics for the same level of variceal pressure. In patients with non-cirrhotic portal hypertension the risk of ... |
### Instruction:
Is molar potency predictive of the speed of onset of atracurium?
### Response:
| The speed of onset of atracurium is slower than predicted, based on its molar potency. Potency of a relaxant may not be a reliable predictor of its time to peak effect, when the drug administered is a mixture of isomers with widely different neuromuscular activities. |
### Instruction:
Does mouse strain modestly influence minimum alveolar anesthetic concentration and convulsivity of inhaled compounds?
### Response:
| Anesthetic potency differs by modest amounts among inbred, outbred, wild, and laboratory mouse strains. Absence of the neural form of protein kinase C increases minimum alveolar anesthetic concentration for isoflurane, indicating that protein phosphorylation by the gamma-isoform of protein kinase C (PKCgamma) can influ... |
### Instruction:
Is the oxidoreductase , biliverdin reductase , induced in human renal carcinoma -- pH and cofactor-specific increase in activity?
### Response:
| Increases in biliverdin reductase expression and activity only with NADH is found in renal cell carcinoma. The net effects of this change are uncertain at present but several pathways, which could be affected by the reductase, may alter local physiology. Biliverdin reductase as a zinc metalloprotein may directly intera... |
### Instruction:
Does preoperative treatment with human chorionic gonadotropin in infancy decrease the severity of proximal hypospadias and chordee?
### Response:
| HCG pretreatment in infancy produces disproportional penile enlargement, which advances the meatus distally to decrease the severity of hypospadias and chordee. This response pattern simplifies the required surgical procedure and appears to improve surgical results. It may benefit select patients, and provide insights ... |
### Instruction:
Does diffusion tensor MRI assess corticospinal tract damage in ALS?
### Response:
| The results support the use of diffusion tensor MRI in detecting pathology of the corticospinal tracts in ALS. |
### Instruction:
Is nutritional status a prognostic factor for survival in ALS patients?
### Response:
| Nutritional surveillance of ALS patients is very important, both in bulbar-onset and spinal-onset patients. |
### Instruction:
Does cardiac uptake of [ 123I ] MIBG separate Parkinson 's disease from multiple system atrophy?
### Response:
| This population assessment of the heart-mediastinum ratio of [123I]metaiodobenzylguanidine uptake showed a high sensitivity for the detection of autonomic involvement in patients with idiopathic IPD and also a high specificity for the discrimination between idiopathic PD and MSA. |
### Instruction:
Does the histologic evaluation of pulsed carbon dioxide laser resurfacing versus phenol chemical peel in vivo?
### Response:
| With the parameters used in this study, phenol peels resulted in the formation of a thicker zone of collagen despite the deeper ablation depth of the laser. |
### Instruction:
Is inhibition of angiogenesis by thrombospondin-1 mediated by 2 independent regions within the type 1 repeats?
### Response:
| These results indicate that the type 1 repeats of TSP-1 contain 2 subdomains that may independently inhibit neovascularization. They also identify 2 independent pathways by which TSP-1 can block FGF-2 and VEGF angiogenic signals on endothelial cells. |
### Instruction:
Is endothelial vasodilator function preserved at the spastic/inflammatory coronary lesions in pigs?
### Response:
| These results indicate that endothelial vasodilator function is preserved at the spastic site and that the spasm is caused primarily by smooth muscle hypercontraction in our porcine model. |
### Instruction:
Do mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro?
### Response:
| Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells via the activity of RMCP 1. Our results suggest that mast cell chymase may play a role in the progression of heart failure, because loss of cardiomyocytes and proliferation of nonmyocardial cells exaggerate its pathophysiology... |
### Instruction:
Does gABA uptake blocker NNC-711 exhibit marked anticonvulsant action in two cortical epileptic models in immature rats?
### Response:
| Primary epileptogenesis in the cerebral cortex was hardly influenced by NNC-711, but the spread of epileptic activity was markedly suppressed. This effect was better expressed in the 18- and 25-day-old animals than in the youngest group. |
### Instruction:
Do genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration?
### Response:
| Genetic differences in sensitivity to cocaine's rewarding effect depend critically on temporal parameters of the place-conditioning procedure. One possible interpretation of these findings is that short trial durations produce conditioned activity responses that interfere more with expression of conditioned place prefe... |
### Instruction:
Does fluoxetine block expression but not development of sensitization to morphine-induced oral stereotypy in rats?
### Response:
| The results indicate that increasing synaptic serotonin will block the expression but not the development of sensitization to the oral stereotypic effects of repeated high doses of morphine. Also, despite the complete blocking of the morphine effect by fluoxetine during the sensitization phase, the presence of signific... |
### Instruction:
Does the nitric oxide synthase cofactor tetrahydrobiopterin reduce allograft ischemia-reperfusion injury after lung transplantation?
### Response:
| Tetrahydrobiopterin administration during lung allograft reperfusion may reduce posttransplantation lung edema and oxygen-derived free radical injury in the graft. This effect is mediated by local enhancement of the nitric oxide/cyclic guanosine monophosphate pathway. |
### Instruction:
Does androgen deprivation therapy for prostate cancer result in significant loss of bone density?
### Response:
| Pre-existing osteopenia and osteoporosis were common in men with prostate cancer before initiating ADT. Both ADT and the duration of ADT were significantly associated with the loss of BMD in men with prostate cancer. |
### Instruction:
Do early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood?
### Response:
| We concluded that early-life seizures, without causing overt cellular injury, predispose the brain to the damaging effect of seizures later in life. |
### Instruction:
Does pneumoperitoneum in healthy humans affect central blood volume or cardiac output?
### Response:
| In healthy anaesthetized subjects, the elevation of mean arterial pressure and central venous pressure in response to pneumoperitoneum was not caused by enhancement in cardiac output or central blood volume. |
### Instruction:
Do iL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis?
### Response:
| In contrast to endotoxin-induced uveitis, both IL-1 and TNF appear to have critical roles in RPAR uveitis. When receptors for these cytokines were deleted, the severity of immune complex-induced uveitis was profoundly reduced. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.