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### Instruction:
Does addition of levalbuterol to a pediatric emergency department automated medication management system increase its use?
### Response:
| Use of nebulized levalbuterol, in relation to that of nebulized albuterol, for which it is a substitute, did not significantly change when it was included in the pediatric emergency department automated medication management system. This may reflect the lack of substantial benefit that levalbuterol offers over nebulize... |
### Instruction:
Does ocular application of nerve growth factor protect degenerating retinal ganglion cells in a rat model of glaucoma?
### Response:
| These findings indicate that NGF can exert protective action on RGC degeneration occurring in glaucomatous retina. We suggest that ocular NGF treatment might be a suitable pharmacologic approach to investigate protective mechanisms of degenerating RGCs. |
### Instruction:
Do schistosoma mansoni soluble egg antigens enhance HCV replication in mammalian cells?
### Response:
| HepG2 cells as well as whole blood cultures maintain HCV replication. Furthermore, SEA has the potential to enhance HCV propagation. |
### Instruction:
Is dual low response to acetylsalicylic acid and clopidogrel associated with myonecrosis and stent thrombosis after coronary stent implantation?
### Response:
| Dual LR to ASA and CLO is associated with an increased risk for short-term ischemic events after coronary stent implantation. |
### Instruction:
Do cardiac hormones eliminate some human squamous lung carcinomas in athymic mice?
### Response:
| Three of four cardiac hormones synthesized by the atrial natriuretic peptide gene can eliminate human squamous cell lung carcinomas in athymic mice when treated subcutaneously for 4 weeks. The 4th cardiac hormone, i.e. long-acting natriuretic peptide, decreased the volume of one squamous cell lung carcinoma to 2% of th... |
### Instruction:
Does endothelin receptors blockade blunt hypoxia-induced increase in PAP in humans?
### Response:
| A single oral dose of bosentan blunted an acute hypoxia-induced increase in PASP in healthy subjects, without altering cardiac output or systemic blood pressure. |
### Instruction:
Does restriction of HIV-1 genotypes in breast milk account for the population transmission genetic bottleneck that occurs following transmission?
### Response:
| Despite marked restriction of HIV-1 quantities in milk, our data indicate intermixing of virus between blood and breast milk. Thus, we found no evidence that a restriction in viral genotype diversity in breast milk accounts for the genetic bottleneck observed following transmission. In addition, our results highlight t... |
### Instruction:
Do effect of the combination of sodium hypochlorite and chlorhexidine on dentinal permeability and scanning electron microscopy precipitate observation?
### Response:
| The combination of 1% NaOCl and 2% CHX solutions results in the formation of a flocculate precipitate that acts as a chemical smear layer reducing the dentinal permeability in the apical third. |
### Instruction:
Are nF-kB and Bcl-3 activation prognostic in metastatic colorectal cancer?
### Response:
| Activation of canonical NF-kappaB subunits p50 and p65 as measured by nuclear expression is strongly associated with survival suggesting NF-kappaB as a prognostic factor in this disease. Primary tumor nuclear expression appears to be as good as, or better than, metastatic sites at predicting prognosis. Bcl-3 nuclear ex... |
### Instruction:
Is season of birth significantly associated with the risk of completed suicide?
### Response:
| Our results from a large sample of suicide completers from Hungary--a country with one of the highest suicide rates in the world over the last century--strongly support the concept that the season of birth is significantly associated with the risk of completed suicide. |
### Instruction:
Does brain death disrupt structure and function of pig liver?
### Response:
| The NF-kappaB activated by brain death promotes synthesis and release of inflammatory mediators, resulting in hepatic dysfunction. |
### Instruction:
Does lipocalin2 protect against airway inflammation and hyperresponsiveness in a murine model of allergic airway disease?
### Response:
| These data indicate a protective role for Lcn2 in allergic airway disease, suggesting a pro-apoptotic effect as the underlying mechanism. |
### Instruction:
Does [ Aerobic exercise improve physical capacity in patients under chronic hemodialysis ]?
### Response:
| Aerobic exercise conducted during hemodialysis sessions contributed to the improvement of physical capacity and control of hypertension in patients with chronic kidney disease. |
### Instruction:
Does treatment with imiquimod enhance antitumor immunity induced by therapeutic HPV DNA vaccination?
### Response:
| Thus, our data suggests that the combination of therapeutic HPV DNA vaccination with topical treatment with the TLR7 agonist imiquimod enhances the antitumor immunity induced by DNA vaccination. The current study has significant implications for future clinical translation. |
### Instruction:
Does lOH analysis of genes around D4S2964 identify ARD1B as a prognostic predictor of hepatocellular carcinoma?
### Response:
| LOH in genes around D4S2964 may play an important role in HCC development and progression. LOH in ARD1B and SEPT11 could serve as novel prognostic predictors in HCC patients. |
### Instruction:
Does mEOX2 regulate nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta?
### Response:
| Our results represent the first report of an interaction between a homeobox protein and IkappaBbeta and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components. These observations implicate MEOX2 as a potentially important regulatory gene inhibiting not only the angi... |
### Instruction:
Does dedicated Shift Wrap-up Time Improve Resident Sign-out Volume or Efficiency?
### Response:
| The additional hour devoted to wrapping up patients in the ED had no affect on SO burden. The SO burden represented a fixed percentage of the total number of patients seen by the residents. PGY3s sign-out a smaller percentage of patients seen compared to other classes, and have faster TATs. |
### Instruction:
Is hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants the complex result of BK virus infection , preparative regimen intensity and donor type?
### Response:
| Hemorrhagic cystitis is the result of a complex interaction of donor type, preparative regimen intensity, and BK viruria. |
### Instruction:
Does mD-354 selectively antagonize the antinociceptive effects of ( - ) nicotine in the mouse tail-flick assay?
### Response:
| MD-354 selectively antagonizes the antinociceptive actions of (-)nicotine in the tail-flick, but not in the hot-plate assay, or either the motor effects, or discriminative stimulus effects of (-)nicotine. The most parsimonious explanation is that MD-354 might act as a negative allosteric modulator of alpha 7 nACh recep... |
### Instruction:
Is uncoupling of collagen II metabolism in newly diagnosed , untreated rheumatoid arthritis linked to inflammation and antibodies against cyclic citrullinated peptides?
### Response:
| These results suggest that cartilage collagen formation and degradation are unbalanced when RA is diagnosed. The different associations of collagen II anabolism (PIIANP) and collagen II degradation (CTX-II) with anti-CCP, synovitis, and radiographic progression indicate that at this early stage of RA, cartilage collage... |
### Instruction:
Does chemical genetic inhibition of Mps1 in stable human cell lines reveal novel aspects of Mps1 function in mitosis?
### Response:
| Mps1 is involved in the regulation of multiple key processes that ensure correct chromosome segregation and is a promising target for inhibition in anti-cancer strategies. We report here two cell lines that allow specific and highly penetrant inhibition of Mps1 in a reproducible manner through the use of chemical genet... |
### Instruction:
Does delivery of RNA interference trigger to sensory neurons in vivo using herpes simplex virus?
### Response:
| The potential to use inducible or tissue-specific promoters and to simultaneously silence multiple gene targets, in addition to recent studies suggesting that artificial miRNAs may have improved safety profiles, hold clear advantages for the use of miRNA-based vectors for gene silencing in sensory neurons. |
### Instruction:
Are intima-media thickness of common carotid and brachial arteries and prothrombin fragment 1 + 2 associated with left ventricular diastolic dysfunction in patients with myocardial infarction?
### Response:
| In a population sample of patients with myocardial infarction, late diastolic filling time and mitral E/A were associated with cIMa of common carotid and brachial arteries, systolic blood pressure, and prothrombin fragment 1 + 2, suggesting a relationship between diastolic dysfunction, thrombin generation and atheroscl... |
### Instruction:
Does critical flicker frequency fail to disclose brain dysfunction in patients with primary biliary cirrhosis?
### Response:
| CFF fails to determine brain dysfunction in non-encephalopatic patients with PBC, suggesting that functional efficiency of their cerebral cortex remains unaffected and other central mechanisms are responsible for chronic fatigue in these patients. |
### Instruction:
Is repetitive transcranial magnetic stimulation efficacious as an add-on to pharmacological therapy in complex regional pain syndrome ( CRPS ) type I?
### Response:
| This study shows an efficacy of repetitive sessions of high-frequency rTMS as an add-on therapy to refractory CRPS type I patients. It had a positive effect in different aspects of pain (sensory-discriminative and emotional-affective). It opens the perspective for the clinical use of this technique. |
### Instruction:
Does sIRT1 modulate expression of matrix metalloproteinases in human dermal fibroblasts?
### Response:
| Our findings suggest that SIRT1 exerts a negative regulatory role in the production of MMP-1 and MMP-3 in human dermal fibroblasts. |
### Instruction:
Do desmin mutations as a cause of right ventricular heart failure affect the intercalated disks?
### Response:
| We confirmed that either an ARVC-like phenotype or a severe cardiomyopathy with right ventricular involvement are possible, yet infrequent, cardiac phenotypes in DRM. Moreover, we demonstrated that the DES mutation p.R454W affects the localization of desmoplakin and plakophilin-2 at the intercalated disk, suggesting a ... |
### Instruction:
Is presence of an in situ component associated with reduced biological aggressiveness of size-matched invasive breast cancer?
### Response:
| IDC co-existing with DCIS is characterised by lower proliferation and metastatic potential than size-matched pure IDC, especially if the ratio of DCIS to IDC size is high. We submit that IDC-DCIS is biologically distinct from pure IDC, and propose an incremental molecular pathogenesis of IDC-DCIS evolution involving an... |
### Instruction:
Do selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis?
### Response:
| Although nicotine reduced cytokine responses in vitro, both selective alpha7 nAChR agonists worsened the effects of DSS-induced colitis or were ineffective in those of TNBS-induced colitis. Our data indicate the need for caution in evaluating alpha7 nAChR as a drug target in colitis. |
### Instruction:
Is use of over-the-counter analgesics associated with perceived stress among 25-44-year-olds : a national cross-sectional study?
### Response:
| There was a significant association between perceived stress and OTCA use that could not be explained by potential stress-related pain across all the examined sociodemographic strata. OTCA may be used outside their indication to treat feelings of stress. Those in charge of dispensing medicines and policy makers should ... |
### Instruction:
Does curcumin attenuate airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats?
### Response:
| I/R of the pancreas induced systemic inflammatory responses with respiratory burst, nitrosative stress, and hyperresponses in the airways. Curcumin, which has antioxidant and anti-inflammatory effects, significantly attenuated the inflammatory responses and airway hyperreactivity induced by pancreatic I/R. |
### Instruction:
Is [ A diseased esophagus frequently the cause of chronic hiccup . A prospective study of 184 cases ]?
### Response:
| A diseased esophagus is frequently the cause of chronic hiccup. |
### Instruction:
Does cigarette smoke promote dendritic cell accumulation in COPD ; a Lung Tissue Research Consortium study?
### Response:
| These data indicate that COPD is associated with increased numbers of cells bearing markers associated with Langerhans cells and mature dendritic cells, and that cigarette smoke promotes survival signals and augments survival of dendritic cells. Although CSE suppressed dendritic cell CCR7 expression, migration towards ... |
### Instruction:
Is the transcription factor RBP-J-mediated signaling essential for dendritic cells to evoke efficient anti-tumor immune responses in mice?
### Response:
| The RBP-J-mediated Notch signaling is essential for DC-dependent anti-tumor immune responses. The deficiency of RBP-J impairs the DC-based anti-tumor immunity through affecting series of processes including maturation, migration, antigen presentation and T-cell activation. The Notch signaling pathway might be a target ... |
### Instruction:
Are spindle proteins differentially expressed in the various histological subtypes of testicular germ cell tumors?
### Response:
| In carcinoma in situ of TGCTs the spindle checkpoint proteins MAD2 and BUB1B are significantly less expressed compared to normal testis, while the expression of AURKA is increased. We suggest that these changes may be of importance in the transition from in situ to invasive testicular cancer. |
### Instruction:
Are prostate-specific antigen kinetics during follow-up an unreliable trigger for intervention in a prostate cancer surveillance program?
### Response:
| Postdiagnostic PSA kinetics do not reliably predict adverse pathology and should not be used to replace annual surveillance biopsy for monitoring men on active surveillance. |
### Instruction:
Does laminin induce matrix metalloproteinase-9 expression and activation in human cervical cancer cell line ( SiHa )?
### Response:
| Our findings indicate laminin-induced MMP-9 expression and activation possibly via α2β1 integrin-mediated signaling involving FAK, PI-3K, ERK followed by transcriptional upregulation of MMP-9. |
### Instruction:
Does periodontitis case definition affect the association with renal function in kidney transplant recipients?
### Response:
| These findings underscore the importance of periodontitis ‘case definition’ in the observed statistical associations between periodontitis and systemic disease. |
### Instruction:
Does direct peritoneal resuscitation accelerate primary abdominal wall closure after damage control surgery?
### Response:
| The addition of adjunctive DPR to the damage control strategy shortens the interval to definitive fascial closure without affecting overall resuscitation volumes. As a result, this mitigates intra-abdominal complications associated with open abdomen and damage control surgery and affords better patient outcomes. |
### Instruction:
Are not all desired : providers ' views on interpreters ' emotional support for patients?
### Response:
| Emotional support in bilingual health care is accomplished through the alliance of providers and interpreters, complementing each other to support patients' emotional needs. |
### Instruction:
Does tGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involve SMAD signaling and down-regulation of CCL5?
### Response:
| Our results suggest that TGF-beta1 reduces Abeta-induced microglial chemotaxis via the SMAD2 pathway. The down-regulation of CCL5 by TGF-beta1 at least partially contributes to the clustering of microglia at Abeta aggregates. The attenuating effects of SB431542 upon TGF-beta1-suppressed microglial clustering may be med... |
### Instruction:
Is vimentin a novel anti-cancer therapeutic target ; insights from in vitro and in vivo mice xenograft studies?
### Response:
| In light of these findings, evaluation of Withaferin-A, its analogs, or other anti-vimentin therapeutic approaches in soft tissue sarcoma and "epithelial to mesenchymal transition" clinical contexts is warranted. |
### Instruction:
Is voreloxin an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II?
### Response:
| As a first-in-class anticancer quinolone derivative, voreloxin is a toposiomerase II-targeting agent with a unique mechanistic signature. A detailed understanding of voreloxin's molecular mechanism, in combination with its evolving clinical profile, may advance our understanding of structure-activity relationships to d... |
### Instruction:
Is severe hypocholesterolaemia often neglected in haematological malignancies?
### Response:
| Following these preliminary results, blood cholesterol levels could be potentially considered a good biological marker to follow up the neoplastic process. |
### Instruction:
Is duration of first off-treatment interval prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation?
### Response:
| In patients who completed the first cycle of IAD, a duration of the first off-treatment interval of < or = 40 weeks defines a subset of patients at higher risk of CRPC and death. Conversely, patients with an off-treatment interval of more than 40 weeks have a significantly better long-term prognosis. |
### Instruction:
Do expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors?
### Response:
| We present a molecular signature that can predict, at diagnosis, the likelihood of bladder cancer progression and, possibly, lead to improvements in patient therapy. |
### Instruction:
Does oncogenic K-ras activate p38 to maintain colorectal cancer cell proliferation during MEK inhibition?
### Response:
| Oncogenic K-ras activates p38alpha to maintain cell proliferation during MEK inhibition. MEK-targeting therapeutics can create an acquired tumor cell dependency on p38alpha. |
### Instruction:
Is [ Tumour regression predictive for higher risk of sentinel node involvement in thin melanomas ( Breslow thickness < or = 1 mm ) ]?
### Response:
| The results of the present study and the analysis of the literature show that histological regression of the primary tumour does not seem predictive of higher risk of SLN involvement in thin melanomas. This suggests that screening for SLN is not indicated in thin melanomas, even those with histological regression. |
### Instruction:
Does early postoperative oral intake accelerate upper gastrointestinal anastomotic healing in the rat model?
### Response:
| These results suggest that mechanical loading plays a key role in anastomotic healing. Further investigations are necessary to confirm this suggestion. |
### Instruction:
Does regulator of calcineurin 1 control growth plasticity of adult pancreas?
### Response:
| We profile adaptive pancreatic growth, identify Rcan1 as an important new feedback regulator, and firmly establish that CN-NFAT signaling is required for this response. |
### Instruction:
Are women with TT genotype for eNOS gene more responsive in lowering blood pressure in response to exercise?
### Response:
| Our study shows clearly that women with or without eNOS gene polymorphism had no differences in NO production at basal conditions, but when physical exercise is applied an evident difference is detected showing that the presence of -786T>C eNOS gene polymorphism had a significant impact in the health-promoting effect o... |
### Instruction:
Is fetuin-A associated with calcified coronary artery disease?
### Response:
| Serum fetuin-A levels inversely correlated with advanced calcified coronary artery disease. |
### Instruction:
Do the overlap of interstitial cystitis/painful bladder syndrome and overactive bladder?
### Response:
| Many patients with symptoms of overactive bladder with little or no pain have cystoscopic evidence of interstitial cystitis and a positive Potassium Sensitivity Test. Therapies directed toward the uroepithelial dysfunction and neural upregulation associated with interstitial cystitis/painful bladder syndrome may be an ... |
### Instruction:
Does obesity influence the unique pharmacological properties of different biphasic insulin aspart preparations in patients with type 2 diabetes?
### Response:
| The pharmacokinetic and pharmacodynamic characteristics of the two preparations of biphasic insulin aspart were different; however, they were not influenced by the degree of obesity in type 2 diabetic patients. |
### Instruction:
Does murine toll-like receptor 2 activation induce type I interferon responses from endolysosomal compartments?
### Response:
| The results indicate that TLR2 activation induces pro-inflammatory and type I interferon responses from distinct subcellular sites: the plasma membrane and endolysosomal compartments respectively. Apart from identifying and characterizing a novel pathway for induction of type I interferons, the present study offers new... |
### Instruction:
Do recovery expectations predict recovery in workers with back pain but not other musculoskeletal conditions?
### Response:
| Recovery expectations provide some information for predicting future recovery in workers filing injury claims for back pain, but do not seem to predict recovery in claimants with other musculoskeletal conditions. |
### Instruction:
Does n-Acetyl L-Cysteine protect mouse ears from the effects of noise*?
### Response:
| There were no statistically significant differences in ABR threshold shifts between the mice receiving L-NAC and the control mice. This indicates that L-NAC was not effective in preventing permanent threshold shift in this mouse model of NIHL. |
### Instruction:
Do natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity?
### Response:
| Cross-recognition of CTL epitopes from wild-type and naturally-occurring HCV variants may lead to impaired immune responses and ultimately contribute to viral persistence. |
### Instruction:
Do epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells?
### Response:
| Our data provide fundamental evidence for the epigenetic control of MHC in hESCs and iPSCs. Reduced MHC class I and class II expression in hESCs and iPSCs can limit their recognition by the immune response against these cells. The knowledge of these mechanisms will further allow the development of strategies to induce ... |
### Instruction:
Do oscillatory breathing and exercise gas exchange abnormalities prognosticate early mortality and morbidity in heart failure?
### Response:
| Cardiopulmonary exercise testing parameters are powerful prognosticators of early mortality and morbidity in patients with CHF, especially the optimal 2-predictor model of a combination of elevated lowest .VE/.VCO(2) and OB. |
### Instruction:
Is metabolic syndrome associated with more pronounced impairment of left ventricle geometry and function in patients with calcific aortic stenosis : a substudy of the ASTRONOMER ( Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin )?
### Response:
| Notwithstanding AS severity and increase in hemodynamic load, MetS is independently associated with more pronounced LV concentric hypertrophy and worse myocardial function in patients with AS, which may, in turn, predispose them to the occurrence of adverse events. (Effects of Rosuvastatin on Aortic Stenosis Progressio... |
### Instruction:
Do existing risk prediction methods for elective abdominal aortic aneurysm repair predict short-term outcome following endovascular repair?
### Response:
| None of the available scores predicted the outcome of EVR with enough accuracy to be recommended for clinical use. To improve preoperative risk prediction in EVR validation of new systems is required, taking into account morphologic features of the aneurysm to predict medium-term morbidity and re-intervention. |
### Instruction:
Does transcriptional silencing of the ETS1 oncogene contribute to human granulocytic differentiation?
### Response:
| Our results indicated that a decreased expression of Ets-1 protein generalizes to granulocytic differentiation and may represent a crucial event for granulocytic maturation. |
### Instruction:
Does culture of non-genital sites increase the detection of gonorrhea in women?
### Response:
| Pharyngeal gonorrhea is as high in adolescent women from a children's hospital as in adult women from an STD clinic. Without pharyngeal culture, 11-26% of infected adolescent women would be missed. Increased pharyngeal testing may impact the gonorrhea epidemic among adolescent women. |
### Instruction:
Do core promoter structure and genomic context reflect histone 3 lysine 9 acetylation patterns?
### Response:
| Clustering core promoters according to their surrounding acetylation signal is a promising approach for the study of histone modifications. When examining promoters clustered into groups according to their surrounding H3K9 acetylation signal, we find that the relative localization and intensity of H3K9ac is very specif... |
### Instruction:
Are serum levels of total p-cresylsulphate associated with angiographic coronary atherosclerosis severity in stable angina patients with early stage of renal failure?
### Response:
| This study indicates that serum total PCS levels are significantly higher in the presence of CAD and are correlated with the severity of the disease, which suggest that increased serum total PCS may be involved in the pathogenesis of coronary atherosclerosis. |
### Instruction:
Does epidermal growth factor induce HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells?
### Response:
| EGF-induced HCCR-1 over-expression is mediated by PI3K/AKT/mTOR signaling which plays a pivotal role in pancreatic tumor progression, suggesting that HCCR-1 could be a potential target for cancer therapeutics. |
### Instruction:
Is coronary distensibility index measured by computed tomography associated with the severity of coronary artery disease?
### Response:
| CTA-measured CDI is inversely related to the severity of CAD independent of age, sex, cardiovascular risk factors, and CAC. |
### Instruction:
Are sociodemographic and lifestyle factors associated with the use of dietary supplements in a Korean population?
### Response:
| The use of dietary supplements was related to sociodemographic and lifestyle factors in a Korean population. |
### Instruction:
Does genetic background affect function and intracellular calcium regulation of mouse hearts?
### Response:
| These results demonstrate that a different genetic background is associated with physiological differences in cardiac function in vivo and differences in morphology, contractility, and Ca(2+) handling at the cellular level. |
### Instruction:
Do community- and family-level factors influence care-giver choice to screen blood lead levels of children in a mining community?
### Response:
| Children under 6 years of age are currently the least likely to have been screened for lead in Kellogg and screening rates decreased in the 2000s. According to most indicators, socio-economic status did not influence the likelihood of a care-giver to screen children's blood lead levels. However, children in homes with ... |
### Instruction:
Is mean platelet volume associated with insulin resistance in non-obese , non-diabetic patients with coronary artery disease?
### Response:
| We have shown that MPV was significantly elevated in insulin-resistant non-obese, non-diabetic CAD patients when compared to insulin-sensitive non-obese, non-diabetic CAD patients. |
### Instruction:
Does human rhinovirus proteinase 2A induce TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease?
### Response:
| Our findings suggest that patients with severe COPD show T(H)1- and T(H)2-biased responses during AE-COPD. HRV-encoded proteinase 2A, like other microbial proteinases, could provide a T(H)1- and T(H)2-biasing adjuvant factor during upper and lower respiratory tract infection in patients with severe COPD. Alteration of ... |
### Instruction:
Do gene expression profiles help identify the tissue of origin for metastatic brain cancers?
### Response:
| This study demonstrates the accuracy of the Tissue of Origin Test when applied to predict the tissue of origin of metastatic brain tumors. This test could be a very useful tool for pathologists as they classify metastatic brain cancers. |
### Instruction:
Does hedgehog/Gli support androgen signaling in androgen deprived and androgen independent prostate cancer cells?
### Response:
| Collectively, our results indicate that Hh/Gli signaling supports androgen signaling and AI growth in prostate cancer cells in a low androgen environment. The finding that Gli2 co-immunoprecipitates with AR protein suggests that an interaction between these proteins might be the basis for Hedgehog/Gli support of androg... |
### Instruction:
Does genetic variation in glutathione metabolism and DNA repair genes predict survival of small-cell lung cancer patients?
### Response:
| Genetic variations in genes involved in the glutathione and DNA repair pathways are associated with SCLC survival. |
### Instruction:
Does fET family proto-oncogene Fus contribute to self-renewal of hematopoietic stem cells?
### Response:
| Our findings define Fus as a novel regulator of self-renewal and radioprotection of HSCs and also implicate it in stress-resistance and maintenance of the genomic integrity of HSCs. |
### Instruction:
Does rNA interference modulate replication of dengue virus in Drosophila melanogaster cells?
### Response:
| These findings indicate that DENV can replicate in Drosophila S2 cells and that the RNAi pathway plays a role in modulating DENV replication in these cells. S2 cells offer a useful cell culture model for evaluation of the interaction between DENV and the RNAi response. |
### Instruction:
Do outcome predictors and quality of life of severe burn patients admitted to intensive care unit?
### Response:
| In severe burn patients, Baux index, severity of illness on admission to the ICU, complications, and time of first burn wound excision were the major contributors to hospital mortality. Quality of life was influenced by consequences of injury both in psychological and physical health. |
### Instruction:
Does donor-recipient gender and size mismatch affect graft success after kidney transplantation?
### Response:
| The inferior graft survival for female recipients of male donor kidneys is mitigated by male donors with a larger BMI. |
### Instruction:
Does psychometric properties and health correlate of the Geriatric Anxiety Inventory in Australian community-residing older women?
### Response:
| The GAI is a new scale designed specifically to measure anxiety in older people. In this Australian cohort of older women, the instrument had sound psychometric properties. |
### Instruction:
Is the immediate reduction in low back pain intensity following lumbar joint mobilization and prone press-ups associated with increased diffusion of water in the L5-S1 intervertebral disc?
### Response:
| In a group of subjects with LBP, who were classified as being candidates for extension-based treatment, the report of an immediate reduction in pain intensity of 2/10 of greater after a treatment of posterior-to-anterior-directed pressures, followed by prone press-up exercises, was associated with an increase in diffus... |
### Instruction:
Is receptor for advanced glycation end-products ( RAGE ) regulation of adiposity and adiponectin associated with atherogenesis in apoE-deficient mouse?
### Response:
| RAGE-mediated regulation of adiposity in non-diabetic status could be attributable to the progression of atherosclerosis. |
### Instruction:
Is l-type voltage-dependent calcium channel alpha subunit 1C a novel candidate gene associated with secondary hyperparathyroidism : an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms?
### Response:
| These results suggest that CACNA1C may be associated with secondary hyperparathyroidism. In addition, the haplotype-based approach may be useful to screen for key molecules associated with complex traits. |
### Instruction:
Are radiation doses to ERCP patients significantly lower with experienced endoscopists?
### Response:
| Database used is a voluntary reporting system, which may not be generalizable. Data is self-reported and was not verified for accuracy. |
### Instruction:
Does previous cesarean section increase the risk for breech presentation at term pregnancy?
### Response:
| According to the present study, women with a history of at least one cesarean delivery have an increased risk for breech presentation in the subsequent singleton pregnancy at-term. |
### Instruction:
Are obesity and daytime pulse pressure predictors of left ventricular hypertrophy in true normotensive individuals?
### Response:
| Obesity may represent a significant cardiovascular risk factor even in normotensive individuals. Other predictors of LVMI were ageing and daytime PP. |
### Instruction:
Are demographic variables associated with knowledge , attitudes , and preventive behaviors related to environmental tobacco smoke?
### Response:
| Differences in apparent ETS knowledge of specific ETS health effects by varying response format suggest that open-ended surveys may be useful in identifying specific content areas to address in public health education efforts. Various demographic variables predicted ETS knowledge, attitudes, and preventive behaviors, h... |
### Instruction:
Does expression of STAMP2 in monocytes associate with cardiovascular alterations?
### Response:
| In MetS patients, especially women patients, STAMP2 expression was down-regulated in peripheral blood mononuclear cell, which was correlated with carotid atherosclerosis and cardiac adaptation. |
### Instruction:
Do soluble biomarkers differentiate patients with psoriatic arthritis from those with psoriasis without arthritis?
### Response:
| This pilot study indicates that hsCRP, OPG, MMP-3 and the CPII : C2C ratio are biomarkers for PsA in patients with psoriasis. |
### Instruction:
Is the rs2231142 variant of the ABCG2 gene associated with uric acid levels and gout among Japanese people?
### Response:
| The association of the causal ABCG2 rs2231142 variant with uric acid levels and gout was confirmed in a sample of Japanese ancestry. Our study emphasizes the importance of this common causal variant in a population with a high risk allele frequency, especially as more Japanese adopt a Western lifestyle with a concomita... |
### Instruction:
Is combination of serum adiponectin level and metabolic syndrome closely associated with coronary artery disease in Japanese subjects with good glycemic control?
### Response:
| Our findings suggest that the combination of adiponectin levels and the number of MetS components is linked to the severity of CAD in subjects with good glycemic control. |
### Instruction:
Does assessment of health care by children and adolescents depend on when they respond to the questionnaire?
### Response:
| When comparing user satisfaction from different studies and when planning a survey of user satisfaction, the interval between the rendering of the health-care service and the assessment should be taken into consideration. |
### Instruction:
Is discordance of intraoperative frozen section analysis with definitive histology of sentinel lymph nodes in breast cancer surgery : complementary axillary lymph node dissection irrelevant for subsequent systemic therapy?
### Response:
| Discordance between intraoperative FS analysis and definitive histology of SLNs is common. In this selection of patients, a substantial proportion had additional lymph node metastases, but postsurgical treatment was rarely adjusted based on the findings of the complementary ALND. |
### Instruction:
Does sodium bicarbonate lower intracranial pressure after traumatic brain injury?
### Response:
| A single dose of 8.4% sodium bicarbonate is effective at treating rises in ICP for at least 6 h. Serum sodium was raised but without generation of a hyperchloremic metabolic acidosis. |
### Instruction:
Does quercetin attenuate inflammatory processes after spinal cord injury in an animal model?
### Response:
| Quercetin attenuated the recruitment of neutrophils to the site of injury. The resulting lower MPO release in the injured tissue is likely to decrease the extent of secondary injury and might at least partially explain the neuroprotective effect of the flavonoid quercetin. |
### Instruction:
Does transcriptomic analysis of patients with tetralogy of Fallot reveal the effect of chronic hypoxia on myocardial gene expression?
### Response:
| Chronic hypoxia in cyanotic children with tetralogy of Fallot induced the expression of genes associated with apoptosis and remodeling and reduced the expression of genes associated with myocardium contractility and function. |
### Instruction:
Is pneumonectomy a valuable treatment option after neoadjuvant therapy for stage III non-small-cell lung cancer?
### Response:
| Pneumonectomy after neoadjuvant therapy for non-small-cell lung cancer can be performed with a perioperative mortality rate of 3%. Thus, the need of a pneumonectomy for complete resection alone should not be a reason to exclude patients from a potentially curative procedure if done in an experienced center. The 5-year ... |
### Instruction:
Do maltose and maltodextrin utilization by Listeria monocytogenes depend on an inducible ABC transporter which is repressed by glucose?
### Response:
| The data obtained show that in L. monocytogenes the uptake of maltodextrin and, in contrast to B. subtilis, also maltose is exclusively mediated by an ABC transporter. Furthermore, the results suggest that glucose repression of the uptake system possibly is by inducer exclusion, a mechanism not described so far in this... |
### Instruction:
Does catechol-O-methyltransferase val158met genotype modulate sustained attention in both the drug-free state and in response to amphetamine?
### Response:
| The results of this study extend earlier findings with the COMT genotypes to additional measures of cognition, and suggest that the presence of the val allele is associated with poorer performance and greater improvement with a stimulant drug. The results further suggest that this polymorphism does not affect the mood-... |
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