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### Instruction:
Do cyclic bisbibenzyls induce growth arrest and apoptosis of human prostate cancer PC3 cells?
### Response:
| The results suggest that cyclic bisbibenzyls could be used for the development of novel therapeutic chemicals against prostate cancer. |
### Instruction:
Is prevalence of metabolic syndrome comparable between inflammatory bowel disease patients and the general population?
### Response:
| Prevalence of metabolic syndrome in our IBD patients was comparable to that of the general population. Because age was the independent risk factor for developing MS, evaluation for MS is needed for elderly IBD patients. |
### Instruction:
Does epigallocatechin-3-gallate ameliorate hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation?
### Response:
| EGCG prevented hyperglycemia-induced embryopathy through inhibition of Forkhead transcription factor 3a activation. This may have been mediated via the activation of Akt. These findings offer the potential for a possible pharmacological prophylaxis for hyperglycemia-induced embryonic malformations. |
### Instruction:
Do anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes?
### Response:
| Using standard and new statistical methods of data analysis, 6/7 anti-V3 human mAbs displayed cross-clade neutralizing activity and revealed that a significant proportion of viruses can be neutralized by anti-V3 Abs. The new statistical method for analysis of neutralization data provides many advantages to previously u... |
### Instruction:
Are presynaptic actions of general anesthetics responsible for frequency-dependent modification of synaptic transmission in the rat hippocampal CA1?
### Response:
| IV anesthetics, but not volatile drugs, enhance the discharge of a readily releasable pool of GABA vesicles from presynaptic terminals. Depletion of an active pool of GABA after high-frequency stimuli would produce frequency- and use-dependent recurrent inhibition in the presence of IV anesthetics. The stimulus frequen... |
### Instruction:
Is resolution of allergic airway inflammation and airway hyperreactivity mediated by IL-17-producing { gamma } { delta } T cells?
### Response:
| This unfolds a new perspective for the understanding of gammadeltaT cell function with regard to innate regulation of the adaptive immune responses, emphasizing that resolution of responses are important in determining the outcome of acute inflammatory episodes as well as for maintenance of tissue integrity and homeost... |
### Instruction:
Is connexin45 the first connexin to be expressed in the central conduction system of the mouse heart?
### Response:
| These results show connexin45 to be the earliest detectable connexin in the central conduction system and to be the only connexin present throughout the whole conduction system. A distinct temporal pattern of connexin expression was also shown to occur during the development of the conduction tissues of the mouse heart... |
### Instruction:
Are antibodies to CBir1 associated with glycogen storage disease type Ib?
### Response:
| : Nearly all of the patients with GSD-Ib had elevated anti-CBir1 levels. The antibody did not differentiate those with and without a diagnosis of GSD-Ib-associated IBD. Seroreactivity to flagellin may represent immune dysfunction rather than active enterocolitis in this patient population. Long-term follow-up of the gr... |
### Instruction:
Are tbx5 and Bmp signaling essential for proepicardium specification in zebrafish?
### Response:
| Altogether, these data lead us to propose that Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate PE development. |
### Instruction:
Does promotion of CHIP-mediated p53 degradation protect the heart from ischemic injury?
### Response:
| We found that downregulation of CHIP level by hypoxia was responsible for p53 accumulation in the heart after myocardial infarction. Decreasing the amount of p53 prevented myocardial apoptosis and ameliorated ventricular remodeling after myocardial infarction. We conclude that anti-p53 approach would be effective to tr... |
### Instruction:
Does silencing nox4 in the paraventricular nucleus improve myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis?
### Response:
| These results suggest that MI causes dysregulation of Nox4-mediated redox signaling in the PVN, which leads to sympathetic overactivation and a decline in cardiac function. Targeted inhibition of oxidant signaling in the PVN could provide a novel treatment for MI-induced heart failure. |
### Instruction:
Does capromab pendetide scanning have a potential role in optimizing patient selection for salvage cryosurgical ablation of the prostate?
### Response:
| Using our algorithm with CPS and prostate biopsy enabled us to spare some low-risk patients the undue morbidity of local salvage procedures that are likely to fail, while offering selected high-risk patients the opportunity for cure, avoiding premature ADT. Low presalvage PSA seems to be correlated with successful outc... |
### Instruction:
Does mometasone furoate nasal spray reduce the ocular symptoms of seasonal allergic rhinitis?
### Response:
| This prospective study demonstrates that MFNS significantly reduces ocular symptoms in subjects with SAR. |
### Instruction:
Does simvastatin attenuate hypomyelination induced by hypoxia-ischemia in neonatal rats?
### Response:
| The present study shows that simvastatin treatment in neonatal rats attenuates HI-induced developing oligodendrocytes injury and hypomyelination. Its anti-inflammatory properties via suppression of microglial activation are likely to contribute to this action. It provides experimental evidence to support the neuroprote... |
### Instruction:
Does functional magnetic resonance imaging reveal age-related alterations to motor networks in weighted elbow flexion-extension movement?
### Response:
| The current study is the first to demonstrate significant differences in brain activation between old and young subjects during weighted elbow flexion-extension movement when both the old and young groups maintain the same performance level. In particular, overactivation of the basal ganglia in the aging brain appears ... |
### Instruction:
Does acid suppression by proton pump inhibitors enhance aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse?
### Response:
| PPI administration increased the number of parietal cells with enhanced expression of AQP4 and KCNQ1. |
### Instruction:
Does radiation therapy induce circulating serum Hsp72 in patients with prostate cancer?
### Response:
| The current study confirms for the first time in an actual clinical setting elevation of circulating serum Hsp72 with XRT. The accompanying studies in mice and in vitro identify the released exosomes containing Hsp72 as playing a pivotal role in stimulating pro-inflammatory immune responses. These findings, if validate... |
### Instruction:
Is habituation in prepulse inhibition affected by a polymorphism on the NMDA receptor 2B subunit gene ( GRIN2B )?
### Response:
| Although these findings need to be replicated in other samples, an underlying mechanism of impaired biological reaction may be influenced by NMDA hypofunctioning in schizophrenia. |
### Instruction:
Do interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians?
### Response:
| Our findings suggest a strong genetic component in personality traits manifested primarily through interaction effects that occur between genetic factors alone and between genetic and demographic factors. |
### Instruction:
Does intracardiac allogeneic mesenchymal stem cell transplantation elicit neo-angiogenesis in a fully immunocompetent ischaemic swine model?
### Response:
| Allogeneic mesenchymal stem cell transplantation enhances angiogenesis after myocardial infarction. This effect is limited to the viable myocardium. Using a concomitant 12-day course of tacrolimus, no mesenchymal stem cell-specific cellular immune response was demonstrated. |
### Instruction:
Does amino acid accumulation limit the overexpression of proteins in Lactococcus lactis?
### Response:
| We show that the availability of branched chain amino acids is a critical factor for the (over)expression of proteins in L. lactis. The forward engineering of cells for functional protein production required fine-tuning of co-expression of the branched chain amino acid transporter. |
### Instruction:
Does midterm prospective evaluation of TVT-Secur reveal high failure rate?
### Response:
| Mean postoperative follow-up was 30.2 +/- 9.8 mo (range: 11-40 mo). Short-term evaluation showed a 93.5% success rate, but, at last follow-up, only 18 (40%) patients were cured, while 8 (18%) were improved, and 19 (42%) failed. Twelve patients underwent implantation of TVT or transobturator tape during follow-up. Age, ... |
### Instruction:
Do mental disorders and service use among welfare and disability program participants in fee-for-service Medicaid?
### Response:
| The proportion of TANF recipients using mental health services was lower than the proportion of TANF recipients identified through surveys as having a mental disorder, most likely because some TANF recipients had mental disorders that were undiagnosed and untreated. Among those using services, some had patterns of use ... |
### Instruction:
Does transthoracic echocardiography reliably predict involvement of the aortic valve in patients with a discrete subaortic shelf?
### Response:
| Echocardiography is not sensitive in assessing whether a discrete subaortic membrane involves the aortic valve. Since the morbidity and mortality for discrete subaortic membrane resection is negligible, resection may be indicated at the time of diagnosis to minimise aortic valve impairment. |
### Instruction:
Does distal seminal vesicle invasion by prostate adenocarcinoma occur in isolation of proximal seminal vesicle invasion or lymphovascular infiltration?
### Response:
| In this study, as distal SV invasion in the absence of proximal SV invasion was found in <2% of cases, we conclude that sampling of the proximal third of the SVs is sufficient to identify virtually all cases of tumour infiltration into the SVs. If lymphovascular invasion is present in the absence of proximal SV invasio... |
### Instruction:
Is y chromosome loss a frequent early event in urothelial bladder cancer?
### Response:
| The data of this study show that Y chromosome losses are frequent in urothelial bladder cancer of all grades and stages, which could imply that loss of the Y chromosome is an early event in bladder cancer development. p53 mediated genomic instability is evidently not required for the development of Y chromosome losses.... |
### Instruction:
Are early depressive symptoms after ischemic stroke associated with a left lenticulocapsular area lesion?
### Response:
| Patients with ischemic stroke, particularly in the left lenticulocapsular area, should be carefully evaluated for early detection and treatment of depressive symptoms, which may greatly influence outcome. |
### Instruction:
Do discontinuous pulmonary arteries preclude good Fontan outcomes?
### Response:
| This experience indicates that a resuscitative strategy for discontinuous pulmonary arteries can result in good outcomes after the Fontan procedure. The presence of discontinuous pulmonary arteries in patients with single ventricle physiology should not preclude a management strategy with the goal of Fontan candidacy. |
### Instruction:
Is weight loss after gastric bypass surgery in women followed by a metabolically favorable decrease in 11beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue?
### Response:
| Weight loss after gastric bypass surgery was followed by metabolically favorable changes in insulin sensitivity, circulating leptin and adiponectin, and peripheral glucocorticoid metabolism. A significant reduction in 11beta-HSD1 expression was observed in sc adipose tissue after weight loss. This suggests that up-regu... |
### Instruction:
Is serum retinol binding protein 4 level related with renal functions in Type 2 diabetes?
### Response:
| According to the data obtained from this study, diabetic retinopathy and cardiovascular complications do not affect the serum RBP4 level in Type 2 diabetes. Renal functions rather than the metabolic factors of diabetes determine the RBP4 level and its relation with its ligands. |
### Instruction:
Do allergic rhinitis patients with recurrent acute sinusitis have increased sinonasal epithelial cell TLR9 expression?
### Response:
| The significant difference in expression of TLR9 in allergic sinusitis patients compared with allergy-only patients in this study may indicate a difference in the role of innate immunity in these groups. The results suggest that expression of innate immune markers such as TLR9 may be upregulated in response to repeated... |
### Instruction:
Do astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors?
### Response:
| Given their occult nature, opportunities to study premalignant stem/progenitor cells in human have been few. The ability to propagate and direct the differentiation of aneuploid hESCs provides a powerful in vitro system for investigating biological properties of human cells exhibiting features of premalignant stem cell... |
### Instruction:
Is early atropine safer than conventional atropine administration in the elderly undergoing dobutamine stress echocardiography?
### Response:
| In elderly patients undergoing dobutamine stress echocardiography, adopting the early atropine protocol offers a shorter test duration and a lower dobutamine dose, with consequently fewer adverse effects. |
### Instruction:
Does treatment of trichomoniasis in pregnancy in sub-Saharan Africa appear to be associated with low birth weight or preterm birth?
### Response:
| In pregnant women in sub-Saharan Africa, most of whom were HIV-infected, neither trichomoniasis nor its treatment appears to influence the risk of preterm birth or a low-birth-weight infant. |
### Instruction:
Does water extract of Zizyphus Jujube attenuate ischemia/reperfusion-induced liver injury in rats ( PP106 )?
### Response:
| These results suggested that I/R-induced liver injury with white blood cell activation, oxidative stress, and nitrosative stress. Pretreatment with an extract of ZJ, which shows high antioxidant effects, significantly attenuated the I/R-induced liver injury. |
### Instruction:
Does three-dimensional object recognition learning alter an early ERP component of N1?
### Response:
| These results suggest that object recognition learning differentiates between the representations of the objects, at least at the N1 level. |
### Instruction:
Is gamma-aminobutyric acid ( GABA ) an autocrine excitatory transmitter in human pancreatic beta-cells?
### Response:
| Signaling via GABA and GABA(A)R constitutes an autocrine positive feedback loop in human beta-cells. The presence of GABA(A)R in non-beta-cells suggests that GABA may also be involved in the regulation of somatostatin and glucagon secretion. |
### Instruction:
Does work impairment in bipolar disorder patients -- result from a two-year observational study ( EMBLEM )?
### Response:
| Work impairment in bipolar disorder is maintained over long periods, and is strongly associated with relationship status, living conditions and various disease-related factors. |
### Instruction:
Do midterm outcomes in supravalvular aortic stenosis demonstrate the superiority of multisinus aortoplasty?
### Response:
| Despite a longer cross-clamp time, SVAS repair by Doty or Brom aortoplasty restores normal hemodynamics and reduces the need for reoperation when compared with the classic one-patch technique. Our current preference for SVAS repair is the Brom three-patch symmetric aortoplasty. |
### Instruction:
Does impaired weight transfer persist at least four months after hip fracture and rehabilitation?
### Response:
| Movement deficits are evident for an extended time frame following rehabilitation for hip fracture. The slower response time following the rehabilitation period highlights ongoing difficulties with weight transfer onto the affected leg. |
### Instruction:
Is cTLA-4 A49G gene polymorphism associated with vitiligo in South Indian population?
### Response:
| Our results indicate that there is no association between CTLA-4 A49G gene polymorphism and vitiligo in southern Indian population. |
### Instruction:
Do prognostic factors and patterns of recurrence in esophageal cancer assert arguments for extended two-field transthoracic esophagectomy?
### Response:
| Radicality and LN ratio are strong prognostic factors. High radicality and adequate nodal assessment are guaranteed by an extended transthoracic approach. |
### Instruction:
Do antibodies to glutamic acid decarboxylase define a form of limbic encephalitis?
### Response:
| High-titer GAD antibodies define a form of nonparaneoplastic LE. This is a chronic, nonremitting disorder and should be included in the differential diagnosis of patients with TLE and mediotemporal encephalitis. Therapeutic trials of other immunotherapies should be undertaken. |
### Instruction:
Does systematic monitoring of disease activity using an outcome measure improve outcomes in rheumatoid arthritis?
### Response:
| Systematic monitoring of disease activity, aiming for at least low disease activity, and frequent followup improves outcome in RA. |
### Instruction:
Do antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex?
### Response:
| AcpP PPMO is active against Bcc infections in vitro and in vivo. |
### Instruction:
Does megestrol acetate improve weight gain in pediatric patients with chronic kidney disease?
### Response:
| MA appears to effectively improve weight gain in pediatric CKD patients with minimal adverse side effects and may therefore serve as a safe, short-term, nutritional strategy. |
### Instruction:
Is prevalence of delirium on admission to postacute care associated with a higher number of nursing home deficiencies?
### Response:
| Although this study is limited by small sample size, limited geographic scope, and crude assessment of quality with deficiency counts, we have found that facilities with more deficiencies admit more persons that satisfy CAM criteria for delirium. It is possible that good facilities often choose to admit and/or are refe... |
### Instruction:
Are variants at DGKB/TMEM195 , ADRA2A , GLIS3 and C2CD4B loci associated with reduced glucose-stimulated beta cell function in middle-aged Danish people?
### Response:
| We found that the lead variants at the DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response. This association underlines the importance of pancreatic beta cell dysfunction in the genetic predisposition to hyperglycaemia and type 2 diabetes. |
### Instruction:
Does ketamine activate cell cycle signaling and apoptosis in the neonatal rat brain?
### Response:
| These findings support a model in which ketamine induces aberrant cell cycle reentry, leading to apoptotic cell death in the developing rat brain. |
### Instruction:
Is deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle influenced by high-fat overfeeding in a birth-weight-dependent manner?
### Response:
| LBW subjects developed peripheral insulin resistance and decreased gene expression of PPARGC1A and OXPHOS genes when challenged with fat overfeeding. The extent to which our finding of a constitutively increased DNA methylation in the PPARGC1A promoter in LBW subjects may contribute needs to be determined. We provide t... |
### Instruction:
Is lack of regression of left ventricular hypertrophy associated with higher incidence of revascularization in hypertension : The LIFE Study?
### Response:
| Higher Sokolow-Lyon voltage during antihypertensive treatment, but not UACR or the Cornell voltage-duration product, was independently associated with higher incidence of coronary as well as peripheral revascularization. |
### Instruction:
Do medication barriers predict adolescent transplant recipients ' adherence and clinical outcomes at 18-month follow-up?
### Response:
| Barriers to adherence are essential to address in an effort to ameliorate adherence difficulties and potentially reduce the incidence of medical complications. |
### Instruction:
Does ovarian cyst fluid of serous ovarian tumors contain large quantities of the brain amino acid N-acetylaspartate?
### Response:
| The high concentration of NAA in cyst fluid of serous EOTs and low serum concentrations of NAA in these patients, suggest a local production of NAA in serous EOTs. Our findings provide the first identification of NAA concentrations high enough to suggest local production outside the human brain. Our findings contribute... |
### Instruction:
Does casein kinase 1 delta ( CK1delta ) regulate period length of the mouse suprachiasmatic circadian clock in vitro?
### Response:
| The results indicate that CK1delta plays a more prominent role than CK1epsilon in the maintenance of 24-hour rhythms in the master circadian oscillator. |
### Instruction:
Do endocannabinoids differentially modulate synaptic plasticity in rat hippocampal CA1 pyramidal neurons?
### Response:
| Our results suggest that CB1 dependent LTD and DSE are differentially expressed at the PP versus SC synapses in the same neurons, which may have an impact on synaptic scaling, integration and plasticity of hippocampal CA1 pyramidal neurons. |
### Instruction:
Is adiposity a major determinant of plasma levels of the novel vasodilator hydrogen sulphide?
### Response:
| Plasma H(2)S levels are reduced in overweight participants and patients with type 2 diabetes. Increasing adiposity is a major determinant of plasma H(2)S levels. |
### Instruction:
Does standard PAH therapy improve long term survival in CTEPH patients?
### Response:
| Our data may generate the hypothesis that specific vasodilative treatment improves outcome in patients with inoperable CTEPH. |
### Instruction:
Does regular primary care lower hospitalisation risk and mortality in seniors with chronic respiratory diseases?
### Response:
| The findings indicate that regular and proactive 'maintenance' primary care, as distinct from 'reactive' care, is beneficial to older CRD patients by reducing their risks of hospitalisation and death. |
### Instruction:
Does leptin deficiency cause insulin resistance induced by uncontrolled diabetes?
### Response:
| We conclude that leptin deficiency plays a key role in the pathogenesis of severe insulin resistance and related endocrine disorders in uDM. Treatment of diabetes in humans may benefit from correction of leptin deficiency as well as insulin deficiency. |
### Instruction:
Is long-term anabolic-androgenic steroid use associated with left ventricular dysfunction?
### Response:
| Cardiac dysfunction in long-term AAS users appears to be more severe than previously reported and may be sufficient to increase the risk of heart failure. |
### Instruction:
Does thymidylate synthase inhibition induce p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells?
### Response:
| We have shown that in the wild-type p53 context of RT4 cells, 5-FU-triggered apoptosis was prominently efficient and mainly regulated by p53-dependent mechanisms, whereas the mutant p53 environment of T24 cells was able to provide notable levels of resistance to apoptosis, basically ascribed to E2F-independent, and sti... |
### Instruction:
Does tumor size predict the biological behavior and influence of operative modalities in hepatocellular carcinoma?
### Response:
| Tumor size can be a predictable surrogate of biological behavior in the preoperative period. When tumor size is 2.1-5 cm, transplantation should be considered first, irrespective of the underlying liver condition. In patients with tumors 5.1-10 cm in size, liver resection is preferred. |
### Instruction:
Is analysis of 9p24 and 11p12-13 regions in autism spectrum disorders : rs1340513 in the JMJD2C gene associated with ASDs in Finnish sample?
### Response:
| In summary, our results give evidence for a possible common locus for OCD and ASDs at 9p24. We speculate that the area may represent a special candidate region for obsessive repetitive symptoms in ASDs. |
### Instruction:
Does signaling via GPR30 protect the myocardium from ischemia/reperfusion injury?
### Response:
| The GPR30 agonist, G-1, improves functional recovery and decreases myocardial inflammation after global I/R. GPR30 may play an important role in estrogen's ability to protect the heart against I/R injury. |
### Instruction:
Is striatal dysfunction marks preexisting risk and medial prefrontal dysfunction related to problem drinking in children of alcoholics?
### Response:
| These findings suggest a preexisting abnormality in ventral striatal function in youth at risk for AUD, which may lead to inappropriate motivational responding, and suggest that with alcohol use, the prefrontal "control" mechanism loses efficiency, further dysregulating the frontostriatal motivational circuitry. |
### Instruction:
Do salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome?
### Response:
| 9,057 full-length reference genes were characterized in S. salar and can be used to identify alleles and gene family members. Comparisons of duplicated genes show that while purifying selection is the predominant force acting on both duplicates, consistent with retention of functionality in both copies, some relaxation... |
### Instruction:
Are relative risk and odds ratio data still portrayed with inappropriate scales in the medical literature?
### Response:
| Given the perpetuation of this problem, it may be time for the International Committee of Medical Journal Editors to address this issue by requiring that figures portraying ratio data use only logarithmic or reciprocal scales. |
### Instruction:
Is failure to perform cholecystectomy for acute cholecystitis in elderly patients associated with increased morbidity , mortality , and cost?
### Response:
| Our study demonstrated that 25% of cholecystectomies on Medicare beneficiaries were not performed on initial hospitalization, leading to readmissions in 38% of surviving patients. For patients requiring readmission, the percentage of open procedures was increased, and the additional Medicare payment was $7,000 per re-a... |
### Instruction:
Does blood-brain barrier disruption with focused ultrasound enhance delivery of chemotherapeutic drugs for glioblastoma treatment?
### Response:
| This study demonstrates a means of increasing localized chemotherapeutic drug delivery for brain tumor treatment and strongly supports the feasibility of this treatment in a clinical setting. |
### Instruction:
Do patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton?
### Response:
| We show that a minimum of 11 kinesin families and 3 protein domain architectures were present in the LCEA. This demonstrates that the microtubule-based cytoskeleton of the LCEA was surprisingly highly developed in terms of kinesin motor types, but that domain architectures have been extensively modified during the dive... |
### Instruction:
Does a1298C polymorphism in the MTHFR gene predispose to cardiovascular risk in rheumatoid arthritis?
### Response:
| Our results show that the MTHFR 1298 A>C gene polymorphism confers an increased risk for subclinical atherosclerosis and CV events in patients with RA. |
### Instruction:
Is metabolic syndrome associated with learning and recall impairment in middle age?
### Response:
| These results indicate that impairments in cognitive functioning associated with metabolic syndrome and type 2 diabetes may begin as early as middle age and are primarily due to insulin resistance. These results demonstrate the importance of screening at-risk adults for insulin resistance in order to initiate lifestyle... |
### Instruction:
Does glycyrrhetinic acid inhibit ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells?
### Response:
| GA inhibits TNF-alpha-stimulated ICAM-1 expression, leading to a decrease in adherent monocytes to HUVEC. This inhibition is attributed to GA interruption of both JNK/c-Jun and I kappaB/NF-kappaB signaling pathways, which decrease activator protein-1 (AP-1) and NF-kappaB mediated ICAM-1 expressions. The results suggest... |
### Instruction:
Do aBCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis?
### Response:
| We identified a new beneficial role of ABCA1, ABCG1 and HDL in dampening the oxidative burst and preserving viability of macrophages following exposure to oxidized phospholipids and/or apoptotic cells. |
### Instruction:
Is the silencing of microRNA 148a production by DNA hypermethylation an early event in pancreatic carcinogenesis?
### Response:
| We show that the hypermethylation of the DNA region encoding miR-148a is responsible for its repression in PDAC precursor lesions and can be a useful tool for the differential diagnosis of PDAC and CP. |
### Instruction:
Are hippocampal and striatal gray matter volume associated with a smoking cessation treatment outcome : results of an exploratory voxel-based morphometric analysis?
### Response:
| These preliminary results suggest that maintaining smoking abstinence is associated with higher pre-quit brain volume in regions that subserve habit learning and visual processing, and lower brain volume in regions that subserve long-term memory processes and visual information processing. Future, large-scale studies c... |
### Instruction:
Do regionally distinct white matter lesions contribute to regional gray matter atrophy in patients with multiple sclerosis?
### Response:
| Results suggest a model whereby a distinct generalized disease process accounts for GM atrophy better than regionally distinct Wallerian degeneration. |
### Instruction:
Does stanniocalcin-1 regulate extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells?
### Response:
| The results indicated that STC1 plays an important role in the early response to mechanical injury by epithelial cells by modulating signaling of extracellular ATP. This is the first report to describe STC1 as a modulator or purinergic receptor signaling. |
### Instruction:
Is functional activity of the OCT-1 protein predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib?
### Response:
| Measurement of OA pretherapy is a predictor for the long-term risk of resistance and transformation in patients with imatinib-treated CML. Early dose-intensity may reduce the negative prognostic impact of low OA. We propose that OA could be used to individualize dosage strategies for patients with CML to maximize molec... |
### Instruction:
Is carbon dioxide insufflation useful for obtaining clear images of the bile duct during peroral cholangioscopy ( with video )?
### Response:
| The number of patients examined was small. |
### Instruction:
Does kITENIN represent a more aggressive phenotype in a murine model of oral cavity squamous carcinoma?
### Response:
| An antisense KITENIN strategy might inhibit distant metastasis and the progression of head and neck squamous cell carcinoma. |
### Instruction:
Are all the 1p19q codeleted gliomas mutated on IDH1 or IDH2?
### Response:
| This exclusive association suggests a new mechanism of tumorigenesis. Perhaps the IDH1/IDH2 mutation is a prerequisite for the occurrence of the t(1;19) translocation, or it is required for the 1p19q codeleted cells to acquire a tumor phenotype. |
### Instruction:
Does schistosoma mansoni infection but not egg antigen promote recovery from colitis in outbred NMRI mice?
### Response:
| The results presented here suggest that SEA treatment could not protect mice from acute colitis. However, both infection with S. mansoni and injection of SEA affect mucosal immune responses. |
### Instruction:
Is iSG20L1 a p53 family target gene that modulates genotoxic stress-induced autophagy?
### Response:
| Our identification of ISG20L1 as a p53 family target and discovery that modulation of this target can regulate autophagic processes further strengthens the connection between p53 signaling and autophagy. Given the keen interest in targeting autophagy as an anticancer therapeutic approach in tumor cells that are defecti... |
### Instruction:
Do career stage and work setting create different barriers for evidence-based medicine?
### Response:
| Both career stage and work setting were associated with perceived barriers to practising EBM. We have included these in our theoretical framework for classification of these barriers. |
### Instruction:
Do [ Sustentaculum tali screw placement for calcaneus fractures -- different navigation procedures compared to the conventional technique ]?
### Response:
| Navigation procedures seem to be helpful for the precise placement of sustentaculum tali screws in cases of operative calcaneus fracture fixation. The kind of application to be used depends on the infrastructure of the department and the navigation-experience of the operating room team. Whereas the fluoro-free procedur... |
### Instruction:
Is measurement of spleen volume useful for distinguishing between simple steatosis and early-stage non-alcoholic steatohepatitis?
### Response:
| Spleen enlargement may be a distinct feature of NASH, especially early-stage NASH. SBI might be a non-invasive and simple method of differentiating NASH and simple steatosis. |
### Instruction:
Do efficacy beliefs predict collaborative practice among intensive care unit nurses?
### Response:
| Healthcare organizations should create working environments that provide intensive care unit nurses with sufficient resources to perform their job well. Further research is needed to design and evaluate interventions for the enhancement of collaborative practice in intensive care units. |
### Instruction:
Does gnRH antagonist cetrorelix inhibit mitochondria-dependent apoptosis triggered by chemotherapy in granulosa cells of rats?
### Response:
| Cetrorelix could reduce the apoptosis in granulosa cells through inhibiting mitochondria-dependent apoptosis triggered by chemotherapy. |
### Instruction:
Are regulatory T cells associated with post-cryoablation prognosis in patients with hepatitis B virus-related hepatocellular carcinoma?
### Response:
| Treg variation is associated with tumor regression or progression in HCC following cryoablation and may be used as a marker to estimate HCC progression. |
### Instruction:
Is mexiletine an effective antimyotonia treatment in myotonic dystrophy type 1?
### Response:
| Mexiletine at dosages of 150 and 200 mg 3 times daily is effective, safe, and well-tolerated over 7 weeks as an antimyotonia treatment in DM1. |
### Instruction:
Do insulin-like growth factor-1 levels contribute to the development of bacterial translocation in sepsis?
### Response:
| These data support the hypothesis that sepsis-induced reductions in IGF-1 levels contribute to the development of bacterial translocation in both a murine model and human subjects. |
### Instruction:
Do cYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation?
### Response:
| The ABCB1 1199G>A, 3435C>T and 2677G>T/A SNPs, appeared to reduce the activity of P-glycoprotein towards Tac, increasing Tac PBMC concentrations. The impact of ABCB1 genetic polymorphisms on Tac blood concentrations was negligible. As increased Tac intracellular concentrations might in turn enhance immunosuppressive st... |
### Instruction:
Are hTR2C promoter polymorphisms associated with risperidone efficacy in Chinese female patients?
### Response:
| Our results indicate that variants in the HTR2C promoter region are likely to affect the risperidone therapeutic effect in female mainland patients. It may be helpful to investigate a combination of other clinical factors to predict atypical antipsychotic efficacy. |
### Instruction:
Does vitamin E reduce cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype?
### Response:
| A pharmacogenomic strategy of screening DM individuals for the Hp genotype and treating those with Hp 2-2 with vitamin E appears to be highly clinically effective. |
### Instruction:
Is microalbuminuria a predictor of chronic renal insufficiency in patients without diabetes and with hypertension : the MAGIC study?
### Response:
| Microalbuminuria is an independent predictor of renal and cardiovascular complications in patients without diabetes and with primary hypertension. |
### Instruction:
Is major LOXL1 risk allele reversed in exfoliation glaucoma in a black South African population?
### Response:
| This represents the first genetic association study of LOXL1 in an ancestral African population with XFG. We have confirmed the association between variants of LOXL1 and XFG. To date, the G allele of the major susceptibility variant rs3825942 has consistently been shown in multiple populations to increase the risk of X... |
### Instruction:
Does moberg Osteotomy shift Contact Pressure Plantarly in the First Metatarsophalangeal Joint in a Biomechanical Model?
### Response:
| There were no differences in peak pressure or first MTPJ contact area, but a plantar shift in the center of pressure occurred after the Moberg osteotomy. |
### Instruction:
Do the Effect of Aroma Hand Massage Therapy for People with Dementia?
### Response:
| This pilot study demonstrated that clinical aromatherapy was clinically safe but did not lead to statistically significant improvements in BPSD or ADL among people with dementia. Further research on therapeutic effects is needed to develop high-quality care with clinical aromatherapy for elderly patients with dementia ... |
### Instruction:
Does storage time modify the gene expression profile of cryopreserved human metaphase II oocytes?
### Response:
| The length of cryostorage has no effect on the gene expression profile of human MII oocytes. |
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