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### Instruction:
Does abnormal Sleep Duration be Associated with a Higher Risk of Accidental Injury?
### Response:
| Most adults sleep between 7 and 8 hours nightly. Adults with sleep time outside this range, with either less or more sleep, have increased rates of accidental injury. These data highlight the need for sufficient quantity and quality of sleep in preventing accidental injury. |
### Instruction:
Is c-reactive protein associated with low-density lipoprotein cholesterol and obesity in type 2 diabetic Sudanese?
### Response:
| The high prevalence of obesity among diabetics, together with elevated levels of triglycerides and CRP, suggest coexistence of dyslipidemia and inflammation in diabetes. Our findings emphasize that diabetics were 5.6 times more likely to have high CRP levels than nondiabetics; as CRP is a predictor of cardiovascular di... |
### Instruction:
Is vitamin D deficiency associated with the severity of COPD : a systematic review and meta-analysis?
### Response:
| Low serum levels of 25(OH)D were not associated with COPD susceptibility, but the high deficiency rate of 25(OH)D was associated with COPD severity. Vitamin D supplementation may prevent COPD exacerbation. |
### Instruction:
Is chronic neuropathic ulcer the most common antecedent of lower limb infection or amputation among diabetics admitted to a regional hospital in Jamaica : results from a prospective cohort study?
### Response:
| Chronic neuropathic ulcer accounted for only 23.4 % of lower limb infections and 27.7% of amputations in this population of diabetics, making it the second most common antecedent of either after acute idiopathic soft tissue infection/ulcer at 30.5 and 34.7% respectively. Trauma as a group (defined as closed puncture wo... |
### Instruction:
Does chronic cat allergen exposure induce a TH2 cell-dependent IgG4 response related to low sensitization?
### Response:
| These experiments suggest that (1) allergen-experienced B cells with the capacity to produce IgG4 are present in allergic subjects and (2) cat allergen exposure induces an IgG4 response in a TH2 cell-dependent manner. Thus IgG4 accumulation could be mediated by chronic activation of the TH2 response, which in turn driv... |
### Instruction:
Does the multifunctional protein CI of potyviruses play interlinked and distinct roles in viral genome replication and intercellular movement?
### Response:
| The helicase domain and C-terminal region of TuMV CI are essential for viral genome replication, and the N-terminal sequence modulates viral cell-to-cell movement. TuMV CI plays both interlinked and distinct roles in replication and intercellular movement. The ability of CI to target PD and interact with CP is associat... |
### Instruction:
Are prior Corneal Scarification and Injection of Immune Serum Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice?
### Response:
| Despite the reduced reactivation and disease, avoidance of both corneal scarification and immune serum should improve the clinical relevance of the UV-B mouse model. |
### Instruction:
Does red Light modulate Ultraviolet-Induced Gene Expression in the Epidermis of Hairless Mice?
### Response:
| This is an initial observation that in mouse red light LLLT more often than not causes opposite gene expression changes or reduces those caused by moderate UVA-UVB irradiation. |
### Instruction:
Is transient sacroiliac joint-related pain a common problem following lumbar decompressive surgery without instrumentation?
### Response:
| The adaptation of a changed body posture and gait could lead to transient overload of the SIJ and surrounding myofascial structures. The patients should be informed about this possible condition to avoid uncertainty, discontent, unnecessary diagnostics and to induce a quick, specific treatment. Non-diagnosed sacroiliac... |
### Instruction:
Does urinary liver-type fatty acid-binding protein predict recovery from acute kidney injury?
### Response:
| Urinary L-FABP appears to be a useful biomarker to predict failure to recover during hospitalization in the cohort of patients with AKIN3. |
### Instruction:
Does anti-Tumor Necrosis Factor Therapy restore Peripheral Blood B-cell Subsets and CD40 Expression in Inflammatory Bowel Diseases?
### Response:
| A lower number of circulating B cells, a low CD40 expression, and a decrease in the proportion of CD5 and in the preswitched memory subset characterize active IBD. Restoration of these abnormalities correlates with the clinical response to anti-TNF therapy. The mechanism for this effect on B cells should be further exp... |
### Instruction:
Does isoliquiritigenin prevent the progression of psoriasis-like symptoms by inhibiting NF-κB and proinflammatory cytokines?
### Response:
| ISL could ameliorate the inflammatory process of psoriasis. ISL could suppress NF-κB and subsequent production of a series of pro-inflammatory cytokines. Dual-inhibitory activity against IL-6 and IL-8 of ISL is implemented via inhibiting NF-κB. ISL exerts no inhibitory effects on normal human keratinocytes or wild-type... |
### Instruction:
Do ancient gene duplications have shaped developmental stage-specific expression in Pristionchus pacificus?
### Response:
| We propose that gene duplications of developmentally regulated genes represent a plausible evolutionary mechanism to increase the dosage of stage-specific expression. Consequently, this may contribute to the substantial divergence in expression profiles that has been observed across larger evolutionary time scales. |
### Instruction:
Are methionine and S-adenosylmethionine levels critical regulators of PP2A activity modulating lipophagy during steatosis?
### Response:
| These data suggest that elevated levels of methionine and SAMe can inhibit autophagic catabolism of lipids contributing to liver steatosis. |
### Instruction:
Is serum potassium decline during hospitalization for acute decompensated heart failure a predictor of 6-month mortality , independent of N-terminal pro-B-type natriuretic peptide levels : An individual patient data analysis?
### Response:
| A percentage serum potassium decline of >15% is an independent predictor of 180-day all-cause mortality on top of baseline potassium levels, NT-proBNP levels, renal variables, and other relevant clinical variables. This suggest that patients hospitalized for ADHF with a decline of >15% in serum potassium levels are at ... |
### Instruction:
Does continued Follow-Up of Phambili Phase 2b Randomized HIV-1 Vaccine Trial Participants support Increased HIV-1 Acquisition among Vaccinated Men?
### Response:
| The additional follow-up from HVTN 503-S supported the Phambili finding of increased HIV-1 acquisition among vaccinated men and strengthened the evidence of lack of vaccine effect among women. |
### Instruction:
Does impairment of Dynamic Pressure Autoregulation precede Clinical Deterioration after Aneurysmal Subarachnoid Hemorrhage?
### Response:
| The results demonstrate the capability of the ARI to serve as a reliable early warning system after SAH. Further trials with larger study populations are needed to validate these promising preliminary data. |
### Instruction:
Is reduction in pulmonary function after CABG surgery related to postoperative inflammation and hypercortisolemia?
### Response:
| Larger reductions in pulmonary function after CABG surgery are present in patients experiencing greater postoperative increases in blood CRP and cortisol levels. Decrements in pulmonary function after CABG surgery are, at least in part, thus related to alterations in circulatory factors that affect muscle protein synth... |
### Instruction:
Does pycnogenol ( ® ) treatment inhibit bone mineral density loss and trabecular deterioration in ovariectomized rats?
### Response:
| Pycnogenol(®) (40 mg/kg) can inhibit aggravated bone resorption, prevent BMD loss, and restore the impaired trabecular microarchitecture in OVX rats after 9-week-intervention. |
### Instruction:
Does associative Learning drive the Formation of Silent Synapses in Neuronal Ensembles of the Nucleus Accumbens?
### Response:
| Our results indicate that silent synapses are formed only in neuronal ensembles of the nucleus accumbens shell that are related to associative learning. |
### Instruction:
Do variants in the CYP7B1 gene region affect natural resistance to HIV-1 infection?
### Response:
| Although our study had limited power to detect association due to the small sample size, comparisons among the three cohorts revealed very similar allelic and genotypic frequencies in HESN and HIV-1 positive subjects. Overall, these data indicate that the two GWAS-defined variants in the CYP7B1 region do not strongly i... |
### Instruction:
Do genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer?
### Response:
| Our study suggests that SNPs in TCA cycle metabolic enzymes might be significantly associated with clinical outcomes in Chinese population diagnosed with CRC. Further functional and validated studies are warranted to expend our results to clinical utility. |
### Instruction:
Is the contribution of PCSK9 levels to the phenotypic severity of familial hypercholesterolemia independent of LDL receptor genotype?
### Response:
| These results suggested that the contribution of PCSK9 levels to the phenotypic severity in FH heterozygotes is independent of LDLR genotype. |
### Instruction:
Are socioeconomic ( SES ) differences in language evident in female infants at 7months of age?
### Response:
| In this single sex and race cohort of healthy, term, female infants, lower SES exerted negative effects on infant language by 7months of age. While maternal vocabulary scores showed no relation with infant language skills at 7months, continued study of the relations between SES, infant outcomes and maternal characteris... |
### Instruction:
Does emotion Dysregulation mediate the Relation between Mindfulness and Rejection Sensitivity?
### Response:
| Longitudinal studies could help in delineating etiological models of RS, and the joint role of deficits in mindfulness and emotion regulation should inform treatment programs. |
### Instruction:
Does tetramethylpyrazine inhibit Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro?
### Response:
| TMP may be an effective Hh signaling pathway inhibitor for hepatic fibrosis treatment. |
### Instruction:
Does artocarpus altilis heartwood extract protect skin against UVB in vitro and in vivo?
### Response:
| The experimental study revealed that A. altilis extract suppresses structural alterations in skin damaged by ultraviolet radiation B irradiation. This suppression was, at least partially, mediated by decrease in MMP-1 production in fibroblasts and TNF-α and IL-6 productions in keratinocytes. |
### Instruction:
Does soft Contact Lens optimize Visual Goals for a Patient with Keratoectasia?
### Response:
| This case highlights the success of the KeraSoft IC soft contact lens for irregular corneas to address specific visual and comfort demands during physical fitness activities. |
### Instruction:
Does electrical Intramuscular Stimulation in Osteoarthritis enhance the Inhibitory Systems in Pain Processing at Cortical and Cortical Spinal System?
### Response:
| The serum BDNF revealed an inverse relationship with PPT independent of the treatment group. These results suggest that a-EIMS enhanced the corticospinal inhibitory systems in cortical and infracortical pain processing sites most likely by bottom-up regulation mechanisms. |
### Instruction:
Does tau phosphorylation regulate the interaction between BIN1 's SH3 domain and Tau 's proline-rich domain?
### Response:
| Our results show that (i) BIN1 and Tau bind through an SH3-PRD interaction and (ii) the interaction is downregulated by phosphorylation of Tau Thr231 (and potentially other residues). Our study sheds new light on regulation of the BIN1/Tau interaction and opens up new avenues for exploring its complex's role in the pat... |
### Instruction:
Does paternal transmission of MTHFD1 G1958A variant predispose to neural tube defects in the offspring?
### Response:
| Our research provides the first evidence supporting a paternal, rather than a maternal, transmission bias of MTHFD1 G1958A variant for NTD susceptibility in the offspring. |
### Instruction:
Does vitamin A maintain the airway epithelium in a murine model of asthma by suppressing glucocorticoid-induced leucine zipper?
### Response:
| Vitamin A maintained the Dex-treated asthma airway epithelium via the down-regulation of GILZ expression and the activation MAPK-ERK signaling, and these effects might contribute to improving the effects of GC therapeutics on asthma. |
### Instruction:
Does parathyroidectomy in asymptomatic primary hyperparathyroidism reduce carotid intima-media thickness and arterial stiffness?
### Response:
| Parathyroidectomy leads to an improvement in the structural and functional impairment associated with atherosclerosis in the vascular wall in asymptomatic hypercalcaemic PHPT patients. |
### Instruction:
Do endothelial- and Platelet-Derived Microparticles Are Generated During Liver Resection in Humans?
### Response:
| Endothelial and platelet-derived microparticles are specifically elevated during liver resection, accompanied by increased procoagulant activity. Leukocyte-derived microparticles are a potential marker for systemic inflammation. Plasma microparticles may represent a specific response to surgical stress and may be an im... |
### Instruction:
Does inhibition of AMPK through Lyn-Syk-Akt enhance FcεRI signal pathways for allergic response?
### Response:
| AMPK is inhibited by FcεRI via Lyn-Syk-Akt signaling in RBL-2H3 cells. AMPK inhibition supports FcεRI-mediated Lyn signaling and allergic response. Metformin has inhibitory effect on passive cutaneous anaphylaxis. |
### Instruction:
Does relative Peripheral Hyperopia Predict Development and Progression of Myopia in Children?
### Response:
| Relative peripheral hyperopia does not predict development nor progression of myopia in children. This calls into question the efficacy of treatments that aim to slow progression of myopia in children by "treating" relative peripheral hyperopia. |
### Instruction:
Does a 3-day high-fat/low-carbohydrate diet alter exercise-induced growth hormone response in healthy males?
### Response:
| We could not show that short-term HF-LC consumption changed significantly exercise-induced GH response or IMCL content in healthy young males. |
### Instruction:
Do serum CXCL12 levels on hospital admission predict mortality in patients with severe sepsis/septic shock?
### Response:
| Our data suggest a possible role for CXCL12 as a prognostic marker in severe sepsis/septic shock and give background evidence for larger trials to evaluate the pathophysiologic and clinical role of CXCL12 in sepsis, with respect to other markers of inflammation and hypoxia. |
### Instruction:
Does co-culture of neuroepithelial stem cells with interstitial cells of Cajal result in neuron differentiation?
### Response:
| These in vitro findings demonstrated that ICCs could induce the neuronal differentiation of NESCs, which connected with differentiated neurons into a network morphologically. The findings provide an experimental basis for in vivo application of the simultaneous transplantation of NESCs and ICCs. |
### Instruction:
Does quantitative proteomics reveal the central changes of wheat in response to powdery mildew?
### Response:
| Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a destructive pathogenic disease in wheat-producing regions worldwide, resulting in severe yield reductions. Although many resistant wheat varieties have been cultivated, there are few reports about the proteomic response to Bgt infection in resistant... |
### Instruction:
Do long-term strategies support autonomy in radiation safety in invasive cardiology?
### Response:
| Our data highlight the efficacy of various radiation-reducing strategies by autonomous control and iterative training in radiation safety toward submillisievert levels for CA, and define realizable benchmarks for comparison with the performance data of any individual. |
### Instruction:
Does ceftriaxone attenuate acute cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens of the rat?
### Response:
| These results are the first evidence that ceftriaxone affects cocaine-evoked dopaminergic transmission, in addition to its well-described effects on glutamate, and suggest that its ability to attenuate cocaine-induced behaviours, such as psychomotor activity, is due in part to reduced dopaminergic neurotransmission in ... |
### Instruction:
Do cloacal malformation patients report similar quality of life as female patients with less complex anorectal malformations?
### Response:
| Patients with cloacal malformations and females with less complex anorectal malformations report similar QoL. Parents of cloacal malformation patients report more problems on several psychosocial domains relative to the healthy reference group. To monitor these matters, long-term follow-up protocols should contain mult... |
### Instruction:
Do hDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis?
### Response:
| The results reveal that HDACs play a role in the regulation of pressure overload-induced miR-133a downregulation. This work is the first to provide insight into an epigenetic-miRNA regulatory pathway in pressure overload-induced cardiac fibrosis. |
### Instruction:
Does sRC3 Phosphorylation at Serine 543 be a Positive Independent Prognostic Factor in ER-Positive Breast Cancer?
### Response:
| Phosphorylation of SRC3 at S543 affects its genomic interactions on a genome-wide level, where SRC3-pS543 is selectively recruited to promoters of ERα-responsive genes. SRC3-pS543 is a prognostic marker, and a predictive marker of response to endocrine therapy. |
### Instruction:
Does blue Light protect Against Temporal Frequency Sensitive Refractive Changes?
### Response:
| Illuminants rich in blue light can protect against myopic eye growth when the eye is exposed to slow changes in luminance contrast as might occur with near work. |
### Instruction:
Does tideglusib protect neural stem cells against NMDA receptor overactivation?
### Response:
| Our study provides the evidence that GSK-3β and PPARγ may be directly involved in pathways leading to NMDA receptor-induced cell death and that the inhibitors including tideglusib may exert neuroprotective effect against these receptor overactivation. |
### Instruction:
Does β-elemene enhance the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation?
### Response:
| This is the first demonstration that β-elemene enhances radiosensitivity of gastric cancer cells, and that the mechanism involves inhibition of Pak1 signaling. |
### Instruction:
Does miR-9a-5p regulate proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1?
### Response:
| Our results suggest that during liver fibrosis, portal hypertension may induce the proliferation, migration and activation of HSCs through the up-regulation of miR-9a-5p, which targets Sirt1. |
### Instruction:
Does silencing of ATPase Inhibitory Factor 1 inhibit Cell Growth via Cell Cycle Arrest in Bladder Cancer?
### Response:
| These results suggest the inhibitory effect of IF1 knockdown on BCa cell proliferation is via the suppression of cyclins and cdks related to G1/S transition and then induction of G0/G1 arrest, and firstly indicate IF1 mediates the tumor cell cycle. We concluded that IF1 may be a novel therapeutic target for BCa. |
### Instruction:
Does inhibition of fatty acid synthase with C75 decrease organ injury after hemorrhagic shock?
### Response:
| Administration of C75 after hemorrhage and resuscitation decreased the increase in serum free fatty acids, decreased markers of tissue injury, downregulated the expression of inflammatory mediators, and decreased neutrophil infiltration and lung injury. Thus, the dual action of inhibiting fatty acid synthesis and stimu... |
### Instruction:
Is endovascular aortic aneurysm repair in patients with narrow aortas using bifurcated stent grafts safe and effective?
### Response:
| EVAR with bifurcated stent grafts is safe and effective in patients with a narrow distal aortic diameter, even when the aortic bifurcation measures <14 mm. Adjunctive balloon dilatation did not result in any bleeding complications from aortic disruption, and limb patency was excellent. Aortouniiliac converters are rare... |
### Instruction:
Is hyperhomocysteinemia an independent predictor of long-term clinical outcomes in Chinese octogenarians with acute coronary syndrome?
### Response:
| In ACS octogenarians, hyperhomocysteinemia is an important predictor for long-term all-cause mortality and MACE. |
### Instruction:
Does methylome profiling reveal functions and genes which are differentially methylated in serrated compared to conventional colorectal carcinoma?
### Response:
| This methylome study demonstrates distinct epigenetic regulation patterns in SAC which are consistent to previous expression profile studies and that DIO3 and FOXD2 might be molecular targets for a specific histology-oriented treatment of CRC. |
### Instruction:
Does comparative paleovirological analysis of crustaceans identify multiple widespread viral groups?
### Response:
| In conclusion, we have unearthed a large diversity of EVEs from crustacean genomes, and shown that four of the five viral groups we uncovered (Bunyaviridae, Circoviridae, Mononegavirales, Parvoviridae) were and may still be present in three to four highly divergent crustacean taxa. In addition, the discovery of recent ... |
### Instruction:
Does total Iron Bioavailability from the US Diet be Lower Than the Current Estimate?
### Response:
| This study provides useful data for evaluating the current value of iron bioavailability from the US diet. |
### Instruction:
Are in vivo siRNA distribution and pharmacokinetics assessed by nuclear imaging modulated according to radiolabelling site?
### Response:
| In this study, we highlighted the large influence of siRNAs radiolabelling position on their biodistribution and pharmacokinetic profiles, and proposed a systematic approach for the imaging of all siRNAs of clinical interest. |
### Instruction:
Does human papillomavirus 16 E6 modulate the expression of host microRNAs in cervical cancer?
### Response:
| Our results indicate that HPV infection and subsequent transformation take place through complex regulatory patterns of gene expression in the host cells, part of which are regulated by the E6 protein. |
### Instruction:
Does aldehyde dehydrogenase-2 protect against myocardial infarction-related cardiac fibrosis through modulation of the Wnt/β-catenin signaling pathway?
### Response:
| The reduction of cardiac fibrosis and the down-regulation of β-catenin, phosphorylated GSK-3β, Wnt-1, and WISP-1 may be mediated by increased ALDH2 activity, leading to reduction of MI-related cardiac fibrosis. |
### Instruction:
Is ventral striatal hypoactivation associated with apathy but not diminished expression in patients with schizophrenia?
### Response:
| Although the results remain significant when controlling for chlorpromazine equivalents, we cannot fully exclude potential confounding effects of medication with atypical antipsychotics. |
### Instruction:
Does gilbert syndrome act as a risk factor of developing gallstone among β hemoglobinopathy Tunisian patients?
### Response:
| Altogether, our data provide evidence that genotypes (TA)6/(TA)7 and (TA)7/(TA)7 and (TA)7 variant present a risk factor of developing gallstone among β hemoglobinopathy Tunisian patients. |
### Instruction:
Is sulfonylurea use associated with larger infarct size in patients with diabetes and ST-elevation myocardial infarction?
### Response:
| This study adds further evidence to the proposed causal relationship between sulfonylureas and adverse cardiovascular events by observing a significant difference in infarct size among type 2 diabetes patients presenting with STEMI. Clinicians should consider this association when prescribing sulfonylureas to manage pa... |
### Instruction:
Is protein N-linked homocysteine associated with recurrence of venous thromboembolism?
### Response:
| Elevated protein N-linked Hcy concentrations, indicating enhanced protein homocysteinylation in vivo, characterize patients with recurrent VTE and this phenomenon is associated with enhanced inflammatory state. |
### Instruction:
Is gLUT4 translocation impaired after acute exercise in skeletal muscle of women with obesity and polycystic ovary syndrome?
### Response:
| A single bout of exercise elicited similar GLUT4 translocation in skeletal muscle of PCOS and CTRL, despite a slightly differential pattern of protein phosphorylation. The absence of impairment in GLUT4 translocation suggests that PCOS patients with obesity and insulin resistance may benefit from exercise training. |
### Instruction:
Does bradykinin Impairs and HOE 140 Protect Rat Hindlimb Skeletal Muscle Against Tourniquet-induced Reperfusion Injury?
### Response:
| After 2 h of total ischemia, infusion of bradykinin during 4 h of reperfusion, worsened the I/R injury in the hindlimb skeletal muscle. |
### Instruction:
Does tacrolimus trough-level variability predict long-term allograft survival following kidney transplantation?
### Response:
| Inferior renal allograft survival was observed in recipients with higher variability in tacrolimus trough-levels. |
### Instruction:
Does morphometric MRI analysis enhance visualization of cortical tubers in tuberous sclerosis?
### Response:
| Morphometric analysis of MRIs in TSC can highlight cortical tubers which are likely to be overlooked in conventional MRI sequences alone. Additionally detected tubers may be of potential importance for both presurgical evaluation and initial diagnosis of TSC. |
### Instruction:
Does hMGB1/RAGE induce IL-17 expression to exaggerate inflammation in peripheral blood cells of hepatitis B patients?
### Response:
| HMGB1, RAGE and IL-17 expression is increased in liver of severe HB patients. HMGB1 and RAGE interaction may contribute to the inflammation of liver enhancing the expression of IL-17, which can be possibly restored through the decline of the HMGB1/RAGE axis. |
### Instruction:
Do exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay?
### Response:
| Both in vitro and in vivo data show that MSCs expressing hGluc can identify and report small tumors or metastases in a simple blood test format. Our novel and simple stem cell-based blood test can potentially be used to screen, detect, and monitor cancer and metastasis at early stages and during treatment. |
### Instruction:
Do handcrafted cuff manometers accurately measure endotracheal tube cuff pressure?
### Response:
| The handcrafted manometers do not provide accurate cuff pressure measurements when compared to a cuff-specific device and should not be used to replace the commercial cuff manometers in mechanically ventilated patients. |
### Instruction:
Does microRNA-21 negatively regulate Treg cells through a TGF-β1/Smad-independent pathway in patients with coronary heart disease?
### Response:
| Because the smad7 expression pattern was similar to that of TGF-β, our study suggests that miR-21 can negatively regulate the frequency of circulating Treg cells through a TGF-β1/smad-independent signaling pathway in PBMCs. |
### Instruction:
Is public reporting of colonoscopy quality associated with an increase in endoscopist adenoma detection rate?
### Response:
| There was no concurrent control group to assess whether the increased ADR was due to a secular trend. |
### Instruction:
Is alloantibody against new platelet alloantigen ( Lap ( a ) ) on glycoprotein IIb responsible for a case of fetal and neonatal alloimmune thrombocytopenia?
### Response:
| This study not only underlines the relevance of rare HPAs on the pathomechanism of FNAIT, but also helps to understand the pitfalls of serologic assays to detect anti-GPIIb alloantibodies. |
### Instruction:
Does differential proteomics reveal age-dependent liver oxidative costs of innate immune activation in mice?
### Response:
| Our paper tackles the open question of the cost of mounting an innate immune response. Evolutionary biologists are familiar since a long time with the concept of trade-offs among key traits of an organism, trade-offs that shape life history trajectories of species and individuals, ultimately in terms of reproduction an... |
### Instruction:
Does versican localize to the nucleus in proliferating mesenchymal cells?
### Response:
| Collectively, these data suggest an intracellular function for versican in vascular cells where it appears to play a role in mitotic spindle organization during cell division. These observations open a new avenue for studies of versican, suggesting even more diverse roles in vascular health and disease. |
### Instruction:
Does incidence of hemorrhage in the pediatric population with placement and removal of external ventricular drain?
### Response:
| The authors found the incidence of hemorrhage at EVD placement to be 10%, and the incidence of hemorrhage on EVD removal to be 21.9% in those patients who underwent imaging after each event. Although none of the hemorrhages were of obvious clinical significance, these data can be useful in decision making, and in discu... |
### Instruction:
Are those harmed by others ' drinking in the US population more depressed and distressed?
### Response:
| Findings suggest recently experiencing particular harms from others' drinking significantly affects mental health (both depression and distress). This confirms in a US population results recently reported in Australasian samples. |
### Instruction:
Does productivity cost decrease after endoscopic sinus surgery for refractory chronic rhinosinusitis?
### Response:
| Daily productivity is negatively impacted by the presence of CRS. The outcomes from this study provide the first insights into the reduced productivity costs associated with receiving ESS for refractory CRS. Future studies with larger sample sizes will need to validate the results from this pilot study. |
### Instruction:
Does diagnostic management and outcomes of pulmonary tuberculosis suspect admitted to a central hospital in Malawi?
### Response:
| The study shows inadequacies in the diagnostic management of PTB suspects in the Zomba Central Hospital, but suggests opportunities for improvement. |
### Instruction:
Is laryngeal penetration on videofluoroscopic swallowing study associated with increased pneumonia in children?
### Response:
| To our knowledge, this is the first study to demonstrate that laryngeal penetration on videofluoroscopic swallowing study is associated with significantly more cases of pneumonia in children. While this remains a retrospective study demonstrating a weak association, the results suggest a need for future prospective stu... |
### Instruction:
Does astragaloside IV protect against polymicrobial sepsis through inhibiting inflammatory response and apoptosis of lymphocytes?
### Response:
| ASI-IV protected mice against polymicrobial sepsis by inhibiting inflammatory response and lymphocyte apoptosis. Therefore, ASI-IV might provide a novel therapeutic approach for septic patients. |
### Instruction:
Do caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats?
### Response:
| CAPE has the effect of anti-hepatic fibrosis, which can be realized through adjusting the expression level of iNOS and CSE. |
### Instruction:
Does endothelial Nitric Oxide Synthase-Derived Nitric Oxide prevent Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation?
### Response:
| We conclude that S-nitrosylation of DHFR at cysteine 7 by eNOS-derived NO is crucial for DHFR stability. We also conclude that NO-induced stabilization of DHFR prevents eNOS uncoupling via regeneration of BH4, an essential eNOS cofactor. |
### Instruction:
Is fibroblast growth factor associated to left ventricular mass index , anemia and low values of transferrin saturation?
### Response:
| FGF-23 is associated with LVMI, anemia and low TSAT in patients with PD. Whether increased FGF-23 is a marker or a potential mechanism of myocardial hypertrophy and anemia in patients with end-stage renal disease (ESRD) requires further study. |
### Instruction:
Are microRNAs in urine biomarkers of multiple myeloma?
### Response:
| Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma. |
### Instruction:
Does trypanosoma cruzi bound to Cytokeratin through Conserved Peptide Motifs Found in the Laminin-G-Like Domain of the gp85/Trans-sialidase Proteins?
### Response:
| Taken together, the present study reinforces previous results from our group implicating the gp85 superfamily of glycoproteins and the intermediate filament proteins cytokeratin and vimentin in the parasite infection process. It also suggests an important role in parasite biology for the conserved laminin-G-like domain... |
### Instruction:
Is hMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells Fas/FasL activation-dependent?
### Response:
| Our results show that interaction of retinal cells with infiltrating uveitogenic T cells leads to rapid release of HMGB1 via the Fas/FasL inflammatory signaling pathway. |
### Instruction:
Does eGF-induced sodium influx regulate EGFR trafficking through HDAC6 and tubulin acetylation?
### Response:
| These studies provide a novel regulatory mechanism to attenuate EGFR signaling in which EGF modulates EGFR trafficking through intracellular sodium-mediated HDAC6 inactivation and tubulin acetylation. |
### Instruction:
Does radix Scrophulariae extracts ( harpagoside ) suppress hypoxia-induced microglial activation and neurotoxicity?
### Response:
| These results suggested that the anti-inflammatory mechanism of harpagoside might be associated with the NF-κB signaling pathway. Harpagoside protect against hypoxia-induced toxicity on microglial cells through HIF-α pathway. |
### Instruction:
Is human papilloma virus detectable in samples of urothelial bladder cancer in a central European population : a prospective translational study?
### Response:
| Using a broad, sensitive assay with prospectively collected specimens of a Central European population we could not detect HPV-DNA in any of the cases. Our results suggest that it is unlikely that HPV infections play a major role in the development of urothelial bladder cancer. |
### Instruction:
Does soshiho-tang water extract inhibit ovalbumin-induced airway inflammation via the regulation of heme oxygenase-1?
### Response:
| These results suggest that SSTW may be used as a valuable therapeutic agent for treating various inflammatory diseases including allergic asthma. |
### Instruction:
Is predictive formula for acute liver failure useful for predicting the prognosis of patients with acute-on-chronic liver failure?
### Response:
| Although ACLF could not be differentially diagnosed from ALF at admission from the laboratory data alone, the J-HEPM effectively predicted the prognosis of liver failure in patients with ACLF. These findings indicate that ACLF patients with high J-HEPM scores require earlier and more intensive care than ALF patients. |
### Instruction:
Is brain sparing effect in growth-restricted fetuses associated with decreased cardiac acceleration and deceleration capacities : a case-control study?
### Response:
| Our study observed for the first time that AC and DC at PRSA analysis are associated with middle cerebral artery PI, but not with uterine or umbilical artery PI, and that there is a significant decrease of AC and DC in association with brain sparing in IUGR fetuses from 25 weeks of gestation to term. |
### Instruction:
Is exposure to vehicular traffic associated to a higher risk of hospitalization for bronchiolitis during the first year of life?
### Response:
| Exposure to air pollution due to vehicular traffic may increase the risk of hospitalization for bronchiolitis in the first year of life. |
### Instruction:
Does interstudy heterogeneity of definitions of diastolic dysfunction severely affect reported prevalence?
### Response:
| A substantial heterogeneity of definitions of DDF was evident among the studies reviewed, and the different definitions had a substantial impact on the reported prevalence of DDF. |
### Instruction:
Is xRCC1 Arg399Gln polymorphism associated with breast cancer in Chinese?
### Response:
| Our results suggest that the XRCC1 Arg399Gln polymorphism may be associated with increased Breast cancer risk among Asians, except Chinese population. |
### Instruction:
Is musical ability associated with enhanced auditory and visual cognitive processing?
### Response:
| We conclude that musical ability as measured by neuropsychological tests is associated with improved short-time cognitive processing both in the auditory and, surprisingly, also in the visual domain. |
### Instruction:
Do hand/foot splitting and the 're-evolution ' of mesopodial skeletal elements during the evolution and radiation of chameleons?
### Response:
| Our data underscores the importance of comparative and phylogenetic approaches when studying development. Body size may have played a role in the characteristic mesopodial skeletal architecture of chameleons by constraining deployment of the skeletogenic program in the smaller and earliest diverged and basal taxa. Our ... |
### Instruction:
Do prevalence of Anal HPV Infection Among HIV-Positive Men Who Have Sex With Men in India?
### Response:
| Almost all Indian HIV-positive MSM had anal HPV infection. The prevalence of HPV 16 was lower and the prevalence of other oncogenic HPV types was higher than in similar populations in North America and Europe. Vaccine-based prevention strategies for HPV infection in India should consider potential differences in HPV ty... |
### Instruction:
Does molecular Epidemiology of Mycobacterium tuberculosis isolate in 100 Patients With Tuberculosis Using Pulsed Field Gel Electrophoresis?
### Response:
| Molecular epidemiology studies of infectious diseases have been useful when bacterial isolates have been clustered in a period of time and in different geographical regions with variable antibiotic resistance patterns. In spite of high geographical differences and different antibiotic resistant patterns, low genetic di... |
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