question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Do predictive value of PWI for blood supply and T1-spin echo MRI for consistency of pituitary adenoma?
### Response:
| Our results suggest that T1-SE imaging may be a simple and useful method for predicting consistency of PA. CBV value can provide helpful information for assessing the blood supply of pituitary macroadenoma. |
### Instruction:
Do horn fly larval survival in cattle dung is reduced by endophyte infection of tall fescue pasture?
### Response:
| These data suggest that endophyte infection of cattle pasture, i.e. modified pasture management, can significantly affect horn fly development. © 2015 Society of Chemical Industry. |
### Instruction:
Does point-of-care ultrasonography improve the diagnosis of splenomegaly in hospitalized patients?
### Response:
| Point-of-care ultrasonography significantly improves examiners' sensitivity in diagnosing splenomegaly. |
### Instruction:
Do a design of experiments approach to validation sampling for logistic regression modeling with error-prone medical records?
### Response:
| The simulation comparisons demonstrate that this DSCVR approach can produce predictive models that are significantly better than those produced from random validation sampling, especially when the event rate is low. |
### Instruction:
Do young patients with colorectal cancer have increased risk of second primary cancers?
### Response:
| Young patients with colorectal cancer have an increased risk of developing second primary cancer. |
### Instruction:
Does printed three-dimensional airway model assist planning of single-lung ventilation in a small child?
### Response:
| Three-dimensional printing of a model of the airway of a small child aided planning of bronchial intubation and single-lung ventilation. Three-dimensional printing of airway structures may have wider application in anaesthesia practice. |
### Instruction:
Do increased Snacking and Eating Occasions Are Associated with Higher Energy Intake among Mexican Children Aged 2-13 Years?
### Response:
| Snacks represent an area for potential improvement in the diets of Mexican children, especially among those aged 6 to 13 y, for whom each additional snack or eating occasion was linked to even greater increases in total daily energy intake. |
### Instruction:
Does brand name to generic substitution of antiepileptic drugs lead to seizure-related hospitalization : a population-based case-crossover study?
### Response:
| Brand-to-generic AED substitution was not associated with an elevated risk of seizure-related hospitalization. |
### Instruction:
Is the association between arthritis and depression intensified by excessive body weight : Findings from a US national survey , 2005-2012?
### Response:
| The association between arthritis and depression is intensified significantly by increased body weight, in particular, among women. |
### Instruction:
Does miRNA-29c regulate cell growth and invasion by targeting CDK6 in bladder cancer?
### Response:
| miR-29c could inhibit the proliferation, migration and invasion of bladder cancer cells via regulating CDK6. in the future, it could be used as a therapeutic target for the treatment of bladder cancer. |
### Instruction:
Does janus-kinase-2 relate directly to portal hypertension and to complications in rodent and human cirrhosis?
### Response:
| Hepatic JAK2/ARHGEF1/ROCK expression is associated with portal hypertension and decompensation in human cirrhosis. The deletion of Jak2 in myofibroblasts attenuated experimental fibrosis and acute inhibition of JAK2 decreased PP. Thus, JAK2 inhibitors, already in clinical use for other indications, might be a new appro... |
### Instruction:
Is tissue alkaline phosphatase involved in lipid metabolism and gene expression and secretion of adipokines in adipocytes?
### Response:
| We suggest that AP-TNAP activity is involved in lipid and energy metabolism of fat cells, and it might regulate glucose metabolism and insulin sensitivity via adipokine synthesis and secretion. |
### Instruction:
Does tAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages rely on constitutive TNF-α signaling and ROS production?
### Response:
| TAKI-induced cytotoxicity is cell context specific, and apoptosis observed in macrophages is dependent on the constitutive autocrine action of TNF-α for RIP1 activation and ROS production. |
### Instruction:
Does cardiovascular Disease predict Severe Hypoglycemia in Patients with Type 2 Diabetes?
### Response:
| A history of CVD was an independent risk factor for the development of SH in patients with type 2 diabetes mellitus. For patients with CVD, modulation of glycemic targets and diabetic education for the prevention of hypoglycemia should be implemented. |
### Instruction:
Do [ Grape seed proanthocyanidin extracts inhibit lipopolysaccharide of Porphyromonas gingivalis ]?
### Response:
| Grape seed proanthocyanidin extracts have inhibitory effect on lipopolysaccharide of Porphyromonas gingivalis. |
### Instruction:
Do [ Effects of calcium hydroxide and Hoshino 's paste on the proliferation of porcine dental papilla cells ]?
### Response:
| Each concentration of Ca(OH)₂in the study has no effect on pDPCs proliferation, while Hoshino's paste can inhibit cell proliferation. |
### Instruction:
Is history of deep vein thrombosis a discriminator for concomitant atrial fibrillation in pulmonary embolism?
### Response:
| History of DVT is a significant discriminator for clinical profile of PE patients. Individuals without DVT had more often cardiac and pulmonary disease with strongest association with AF. Data advocate a potential link between AF and PE. |
### Instruction:
Does implementation of an Acute Care Surgery Service facilitate Modern Clinical Practice Guidelines for Gallstone Pancreatitis?
### Response:
| Implementation of an ACS service resulted in a higher rate of index cholecystectomy and decreased emergency department visits and readmissions for biliary disease, and allowed for increased adherence to clinical practice guidelines for GSP. |
### Instruction:
Do postoperative complications impact on recurrence and survival after curative resection of gastric cancer?
### Response:
| Evidence provided by this study does not support a negative impact of postoperative complications CD ≥ II, sepsis, and intra-abdominal sepsis on the oncologic outcome after curative gastric cancer resection. |
### Instruction:
Is a novel non-invasive index using AFP and APTT associated with liver fibrosis in patients with chronic hepatitis B infection : a retrospective cohort study?
### Response:
| The AA index can be used to predict significant fibrosis, and may decrease the need for liver biopsy in patients with chronic hepatitis B infection. |
### Instruction:
Is eukaryotic translation initiation factor 6 a novel regulator of reactive oxygen species-dependent megakaryocyte maturation?
### Response:
| Taken together, our results show a role for eIF6-driven translation in megakaryocyte development, and unveil the novel connection between translational control and ROS production in this cell subset. |
### Instruction:
Are five heads better than one : preliminary results of team-based learning in a communication disorders graduate course?
### Response:
| The outcomes of this pilot study suggest the effectiveness of TBL as an instructional method that provides student teams with opportunities to apply course content in problem-solving activities followed by immediate feedback. This research also addresses the dearth of empirical information on how graduate programmes in... |
### Instruction:
Does bMP4 depletion by miR-200 inhibit tumorigenesis and metastasis of lung adenocarcinoma cells?
### Response:
| BMP4 functions as a pro-tumorigenic factor in a murine lung cancer model, and its transcription is regulated by miR-200 and GATA4/6. Thus, we propose that BMP4 and its antagonists may be suitable therapeutic targets for the treatment of lung cancer. |
### Instruction:
Is nonalcoholic steatohepatitis strongly associated with sarcopenic obesity in patients with cirrhosis undergoing liver transplant evaluation?
### Response:
| Sarcopenia and sarcopenic obesity is seen in a significant number of patients with cirrhosis undergoing LT evaluation. Sarcopenia progresses after LT initially and does not recover at least within the first year after surgery. Obesity is an independent predictor of pretransplant sarcopenia and NASH was associated with ... |
### Instruction:
Does long-term exposure to pro-inflammatory cytokines inhibit the osteogenic/dentinogenic differentiation of stem cells from the apical papilla?
### Response:
| The pro-inflammatory cytokines TNF-α and IL-1β inhibited mineralization and osteogenic-/dentinogenic-related gene expression in SCAPs in vitro after long-term culturing. However, these cytokines induced cell proliferation and mineralization in short-term culture probably as a protective response. These findings help to... |
### Instruction:
Do monte Carlo calculations support organ sparing in Deep-Inspiration Breath-Hold intensity-modulated radiotherapy for locally advanced lung cancer?
### Response:
| MC calculations revealed (i) that DIBH compared with FB can significantly reduce the dose to the OARs even if the treatment planning is carried out with AAA, and (ii) inferior target dose coverage compared to AAA, irrespectively of FB and DIBH. The dose deviations were similar for FB and DIBH. The observed inferior tar... |
### Instruction:
Does tHAM reduce CO2-associated increase in pulmonary vascular resistance - an experimental study in lung-injured piglets?
### Response:
| The pH in the THAM groups was similar to pH in the controls at 6 h, despite a marked increase in BE. This was due to an increase in PaCO2 after stopping the THAM infusion, possibly by intracellular release of CO2. Pulmonary arterial pressure and PVR were lower in the THAM-treated animals, indicating that THAM may be an... |
### Instruction:
Does the Oral Microbiome of Denture Wearers be Influenced by Levels of Natural Dentition?
### Response:
| This is the first study to provide a detailed understanding of the oral microbiome of denture wearers and has provided evidence that DS development is more complex than simply a candidal infection. Both fungal and bacterial kingdoms clearly play a role in defining the progression of DS, though we were unable to show a ... |
### Instruction:
Does a newly identified susceptibility locus near FOXP1 modify the association of gastroesophageal reflux with Barrett 's esophagus?
### Response:
| Reflux symptoms are more strongly associated with Barrett's esophagus risk among persons homozygous for the major allele of rs2687201, which lies approximately 75 kb downstream of the transcription factor gene FOXP1. |
### Instruction:
Does sulforaphane improve the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways?
### Response:
| These findings suggest the potential value of blocking the bronchoconstrictor hyperresponsiveness in some types of asthmatics by phytochemicals such as sulforaphane. |
### Instruction:
Are meta-analyses with industry involvement massively published and report no caveats for antidepressants?
### Response:
| There is a massive production of meta-analyses of antidepressants for depression authored by or linked to the industry, and they almost never report any caveats about antidepressants in their abstracts. Our findings add a note of caution for meta-analyses with ties to the manufacturers of the assessed products. |
### Instruction:
Does single-stage orthoplastic reconstruction of Gustilo-Anderson Grade III open tibial fractures greatly reduce infection rates?
### Response:
| Joint orthoplastic operating lists facilitate simultaneous definitive fixation and cover that greatly reduces infection rates. Based on our experience presented in this paper, we believe that emphasis should be placed on timely transfer to a specialist centre, aiming for a single-stage combined orthoplastic procedure t... |
### Instruction:
Does weight-reduction through a low-fat diet cause differential expression of circulating microRNAs in obese C57BL/6 mice?
### Response:
| These results imply that obesity-related reductions in the expression of circulating miRNAs could be reversed through changes in metabolism associated with weight reduction achieved through LFD feeding. |
### Instruction:
Does hypoxia Differentially regulate Arterial and Venous Smooth Muscle Cell Migration?
### Response:
| Our study determines that SMC migration under hypoxia occurs via both an autocrine and paracrine mechanism and is dependent on Vascular Endothelial Growth Factor-A (VEGF-A) in V-SMC and PDGF-BB in A-SMC. Migration of both A-SMC and V-SMC is inhibited by p38 MAPK inhibitor. These studies suggest that pharmacotherapeutic... |
### Instruction:
Does gas-phase smile rearrangement reactions of deprotonated N-phenylbenzamides studied by electrospray ionization tandem mass spectrometry?
### Response:
| In the fragmentation of deprotonated N-phenylbenzamides, the gas-phase Smiles rearrangement reaction initiated by either the nitrogen or the oxygen atom can proceed. The findings in this study have not only enriched knowledge on the gas-phase Smiles rearrangement reactions, but also provided valuable information for un... |
### Instruction:
Are changes in transcription of cytokinin metabolism and signalling genes in grape ( Vitis vinifera L. ) berries associated with the ripening-related increase in isopentenyladenine?
### Response:
| The transcriptional analysis of grapevine genes involved in cytokinin production, degradation and response has provided a possible explanation for the ripening-associated accumulation of iP in grapes and other fruit. The pre- and post-veraison-specific expression of different members from each of five gene families sug... |
### Instruction:
Does pharmacological Elevation of Circulating Bioactive Phosphosphingolipids enhance Myocardial Recovery After Acute Infarction?
### Response:
| Acute myocardial infarction (AMI) initiates innate immune and reparatory mechanisms through which bone marrow-derived stem/progenitor cells (BMSPCs) are mobilized toward the ischemic myocardium and contribute to myocardial regeneration. Although it is clear that the magnitude of BMSPC mobilization after AMI correlates ... |
### Instruction:
Does biomechanical characteristics of head injuries from fall in children younger than 48 months?
### Response:
| An infant is more likely to sustain a skull fracture/ICI from a fall above a 0.6 m (2 ft) threshold, based on the height of the head centre of gravity, or with a parietal/temporal or occipital impact. These variables should be recorded when evaluating the likelihood of skull fracture/ICI. |
### Instruction:
Is activation of peroxisome proliferator-activated receptor gamma crucial for antitumoral effects of 6-iodolactone?
### Response:
| These results support the previously proposed mechanism, in which the I2 effects are mediated by 6IL, and they provide further support for the use of I2 as coadjuvant in breast cancer treatment. |
### Instruction:
Does miR-205 suppress the proliferative and migratory capacity of human osteosarcoma Mg-63 cells by targeting VEGFA?
### Response:
| Collectively, these data suggest that miR-205 might function as a tumor suppressor in OS by, at least partially, targeting VEGFA. |
### Instruction:
Does [ MiR-211 promote invasion of hepatoma cells by targeting estrogen receptor alpha ]?
### Response:
| miR-211 promotes invasion of carcinoma cells by directly targeting ESR1. |
### Instruction:
Does annexin A1 be Increased in the Plasma of Preeclamptic Women?
### Response:
| Our data show that increased AnxA1 levels were associated with a systemic inflammatory phenotype in PE, suggesting AnxA1 deregulation in PE pathogenesis. However, more studies are needed to clarify the role of AnxA1 and other proresolving molecules in the context of the systemic inflammatory response in this intriguing... |
### Instruction:
Does preoperative Metyrosine improve Cardiovascular Outcomes for Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma?
### Response:
| In this study, preoperative metyrosine improved intraoperative hemodynamic stability and decreased CVC rates in patients undergoing PCC/PGLresection. These data suggest that the addition of preoperative metyrosine may improve operative outcomes. |
### Instruction:
Do detection of the MicroRNA expression profile in skeletal muscles of burn trauma at the early stage in rats?
### Response:
| The deregulated miRNAs probably play a potential role in the pathogenesis of skeletal muscle wasting in burn trauma. |
### Instruction:
Are lower omega-3 fatty acids associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis : a nested case-control study?
### Response:
| The inverse association between anti-CCP2 positivity and self-reported omega-3 FA supplement use and omega-3 FA % in RBCs suggests that omega-3 FAs may protect against the development of RA-related autoimmunity in pre-clinical RA. |
### Instruction:
Is breech presentation a risk factor for dysplasia of the femoral trochlea?
### Response:
| For some newborns, a high sulcus angle can be found at birth, indicating that trochlear dysplasia can be found from birth. Breech presentation with knees extended appears to be a major risk factor for development of trochlear dysplasia. |
### Instruction:
Does combined Inhibition of Histamine H1 Receptors and Leukotrienes reduce Compound 48/80-Induced Contraction of the Human Bronchus in vitro?
### Response:
| A supra-additive effect is proposed for the antihistamine and the anti-leukotrienes, which might have relevance to human asthma therapy as well; such a combination deserves a large-scale clinical study. These data also indicate that substances like compound 48/80 should be denoted as mast cell activators rather than 'h... |
### Instruction:
Is hyperglycemia-induced downregulation of apolipoprotein M expression via the hexosamine pathway?
### Response:
| It is concluded that both exogenous and endogenous glucosamine were essential for the over-expression of apoM, which may suggest that the increased intracellular content of glucosamine does not be responsible for the depressed apoM expression at hyperglycemia condition. |
### Instruction:
Is chronic Widespread Back Pain Distinct From Chronic Local Back Pain : Evidence From Quantitative Sensory Testing , Pain Drawings , and Psychometrics?
### Response:
| Even after long duration CLP presents with a local hypersensitivity for PPT, suggesting a somatotopically specific sensitization of nociceptive processing. However, CWP patients show widespread ongoing pain and hyperalgesia for different stimuli that is generalized in space, suggesting the involvement of descending con... |
### Instruction:
Does partial purification and biochemical characterization of peroxidase from rosemary ( Rosmarinus officinalis L. ) leave?
### Response:
| The stability against high temperature and extreme pH demonstrated that the enzyme could be a potential POD source for various applications in the medicine, chemical and food industries. |
### Instruction:
Does light-Activated Sealing of Nerve Graft Coaptation Sites improve Outcome following Large Gap Peripheral Nerve Injury?
### Response:
| Light-activated sealing of cross-linked human amnion results in superior outcomes when compared with conventional suture. |
### Instruction:
Does lKB1 deletion cause early changes in atrial channel expression and electrophysiology prior to atrial fibrillation?
### Response:
| Deletion of LKB1 causes early defects in atrial channel expression, action potential generation and conduction, which precede widespread atrial remodelling, fibrosis and AF. LKB1 is critical for normal atrial growth and electrophysiological function. |
### Instruction:
Does caprini venous thromboembolism risk assessment permit selection for postdischarge prophylactic anticoagulation in patients with resectable lung cancer?
### Response:
| One third of VTE events occurred after discharge. Postoperative VTE incidence was correlated with increasing Caprini scores. Patients in the high risk group had an incidence of 10.3%. Elevated scores may warrant extended chemoprophylaxis for patients after discharge. |
### Instruction:
Does centipeda minima ( Ebushicao ) extract inhibit PI3K-Akt-mTOR signaling in nasopharyngeal carcinoma CNE-1 cells?
### Response:
| CME inhibited the proliferation of CNE-1 cells and activation of the PI3K-AKT-mTOR signaling pathway. |
### Instruction:
Do adolescents in a residential school for behavior disorders have an elevated mortality risk in young adulthood?
### Response:
| Adolescents with severe disruptive behavior problems have a seven-fold risk for premature adult-age death compared to matched controls. The most common causes for death were avoidable, substance-related followed by suicide. Effective treatment of mental and substance use related problems during and after the placement ... |
### Instruction:
Do low oxygen levels contribute to improve photohydrogen production in mixotrophic non-stressed Chlamydomonas cultures?
### Response:
| Low levels of oxygen allow for low acetate uptake rates, and paradoxically, lead to efficient and sustained production of hydrogen. Our data suggest that acetate plays an important role in the hydrogen production process, during non-stressed conditions, other than establishing anaerobiosis, and independent of starch ac... |
### Instruction:
Are new paradigms in hepatitis B management : only diamonds forever?
### Response:
| Despite significant treatment advances, there is increased recognition of the need for improved anti-HBV treatments, and new virologic tests for monitoring treatment response. |
### Instruction:
Does four-year results of Summit stem for total hip arthroplasty in Japanese patients?
### Response:
| These short-term results indicate that the Summit stem achieved good initial fixation, although there were some cases of distal fixation. Careful long-term follow-up and observation will be necessary for hips in which stress shielding occurs. |
### Instruction:
Is active Surveillance for Renal Neoplasms with Oncocytic Features Safe?
### Response:
| Although the majority of oncocytic renal neoplasms will grow with time, surveillance appears to remain safe. Patients opting for this strategy should be made aware that a diagnosis of oncocytoma following biopsy is associated with some degree of uncertainty due to the difficulty of differentiating them from other oncoc... |
### Instruction:
Does rIG-I contribute to the innate immune response after cerebral ischemia?
### Response:
| Our findings suggest a role for RIG-I in contributing to the innate immune response after focal cerebral ischemia. |
### Instruction:
Does low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors reveal Evidence of Exposure to Carcinogenic Aristolochic Acid?
### Response:
| LC-WES analysis of archived tumor tissues is a reliable method applicable to investigations of both the exposure to AA and its biologic effects in human carcinomas. |
### Instruction:
Does short-term suppression of Aedes aegypti using genetic control facilitate Aedes albopictus?
### Response:
| There was no evidence for species replacement of Ae. aegypti by Ae. albopictus over the course of this study. No unintentional environmental impacts or elevated operational risks were observed. The potential for this emerging technology to mitigate against disease outbreaks before they become established is discussed. |
### Instruction:
Does up-regulation of microRNA-16 in Glioblastoma inhibit the Function of Endothelial Cells and Tumor Angiogenesis by Targeting Bmi-1?
### Response:
| Collectively, these findings indicate that loss of microRNA-16 may favor glioma angiogenesis, on the contrary overexpression of microRNA-16 in GBM cells plays a critical role in repressing endothelial function and angiogenesis by targeting Bmi-1. microRNA-16 may be a potential therapeutic agent in the treatment of GBM. |
### Instruction:
Is size an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes?
### Response:
| Altogether, these findings suggest that size is a critical determinant of the UVB-protective efficacy of AgNPs in human keratinocytes. |
### Instruction:
Does not All sound Have Negative Effects on Children Undergoing Cardiac Surgery?
### Response:
| Listening to favorable music by children undergoing repair for congenital heart disease resulted in less stress and more relaxation. |
### Instruction:
Does differential expression of the aryl hydrocarbon receptor pathway associate with craniofacial polymorphism in sympatric Arctic charr?
### Response:
| These results suggest a key role of the aryl hydrocarbon receptor (AhR) pathway in the observed craniofacial differences between distinct charr morphotypes. |
### Instruction:
Does hypoxia activate Calpains in the Nerve Fiber Layer of Monkey Retinal Explants?
### Response:
| During hypoxia/reoxygenation in an improved, relevant monkey model, calpains were first activated in the NFL, followed by death of the parent RGCs. This observation suggest that calpain-induced degeneration of retinal nerve fibers may be an underlying mechanism for RGC death in hypoxic retinal neuropathies. |
### Instruction:
Does curcumin protect against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206?
### Response:
| Curcumin is suggested to activate miR-206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose-induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin's effects on fructose-associated podocyte injury. |
### Instruction:
Are limited evidence that cancer susceptibility regions preferential targets for somatic mutation?
### Response:
| Our findings suggest a complex interplay between germline susceptibility and somatic mutation, underscoring the cumulative effect of common variants on redundant pathways as opposed to driver genes. Complex biological pathways and networks likely link these genetic features of carcinogenesis, particularly as they relat... |
### Instruction:
Do itemized NIHSS subsets predict positive MRI strokes in patients with mild deficits?
### Response:
| NIHSS score subsets predict DWI positivity in mild strokes. The presence of neglect or visual field deficits on the NIHSS subsets is most likely to have an MRI correlate even in patients with low NIHSS. |
### Instruction:
Does atrial Function Assessed by Speckle Tracking Echocardiography be a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients?
### Response:
| Age-related changes in atrial function preceding atrial dilation are evident only upon LA strain analysis. LA strain impairment is an independent predictor of POAF irrespective of age and may serve as a surrogate marker for biological processes involved in establishing the substrate for POAF. |
### Instruction:
Is remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke Associated with Significant Alterations in Peripheral Immune Responses?
### Response:
| Our results reveal dramatic immune changes during RIPC-afforded neuroprotection against cerebral ischemia. |
### Instruction:
Does assessment of serum 25-hydroxy vitamin D improve coronary heart disease risk stratification in patients with type 2 diabetes?
### Response:
| Serum 25(OH)VitD is an independent predictor of future adverse CHD events in patients with T2DM. Addition of 25(OH)VitD status to Framingham Risk Score improves CHD risk prediction in patients with T2DM. |
### Instruction:
Is fstl1 involved in the regulation of radial glial scaffold development?
### Response:
| In the present study, we identified a new role for FSTL1 in the development of radial glial scaffolds and the neuronal migration of upper-layer projection neurons. Our findings will improve understanding of the regulation of RGC development and neuronal migration. |
### Instruction:
Are historical loss thinking and symptoms of depression influenced by ethnic experience in American Indian college students?
### Response:
| Results indicated that a strong ethnic identification, desire to predominantly socialize with other American Indians, and perceptions of discrimination were associated with increased historical loss thinking. Feelings of comfort and assimilation with the mainstream American culture were negatively related to historical... |
### Instruction:
Does 18F-FDG-PET/MR increase diagnostic confidence in detection of bone metastases compared with 18F-FDG-PET/CT?
### Response:
| PET/MRI offers higher reader confidence and improved conspicuity in bone metastases compared with PET/CT. However, the overall detection rate was not different. The highest possible clinical impact of PET/MRI appears to be in patients with limited, early bone metastatic disease. |
### Instruction:
Do evaluation of the bristle end-rounding patterns of children 's toothbrushes using scanning electron microscopy and stereomicroscopy?
### Response:
| The types and percentages of bristle ends of children's toothbrushes marketed in Korea were various, but the amount of acceptable end-rounded bristles was low. The result, that even toothbrushes labelled as end-rounded had potential to harm oral tissue, demonstrates that quality control for rounding bristle ends as wel... |
### Instruction:
Is licarin A a candidate compound for the treatment of immediate hypersensitivity via inhibition of rat mast cell line RBL-2H3 cells?
### Response:
| Our results demonstrate that licarin A reduces TNF-α and PGD2 secretion via the inhibition of PKCα/βII and p38 MAPK pathways; this compound may be useful for attenuating immediate hypersensitivity. |
### Instruction:
Is high conductance potassium channels activation by acid exposure in rat aorta endothelium-dependent?
### Response:
| High conductance potassium channel activation induced by acid exposure is endothelium-dependent. |
### Instruction:
Does recurrence of macular edema in eyes with branch retinal vein occlusion change the diameter of unaffected retinal vessels?
### Response:
| Unaffected retinal venular diameters associate with the course of BRVO with ME. This may help elucidate the pathological mechanism underlying BRVO. |
### Instruction:
Does pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverse motor deficits in a rat model of Parkinson 's disease?
### Response:
| Overall, these findings provide evidence that functional modulation of PPN cholinergic neurons alleviates parkinsonian motor symptoms. |
### Instruction:
Does resveratrol selectively induce apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway?
### Response:
| Resveratrol may have therapeutic potential against myeloproliferative neoplasms associated with the aberrant activation of the JAK2 pathway. |
### Instruction:
Does depletion of yeast PDK1 orthologs trigger a stress-like transcriptional response?
### Response:
| By using the tetO7 promoter we elucidated for the first time the transcriptomic changes directly or indirectly caused by progressive depletion of Pkh. Furthermore, this system enabled the characterization of the transcriptional response triggered by heat shock in wild-type and Pkh-depleted cells, showing that about 40 ... |
### Instruction:
Do an update of the blockade of the renin angiotensin aldosterone system in clinical practice?
### Response:
| Monotherapy with an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin II receptor blocker (ARB) remains valid in all the guidelines, whereas their dual combination has been discarded due to the absence of proven benefits in high CV risk patients and in patients with chronic kidney disease (CKD). The comb... |
### Instruction:
Are assessments of endothelial function and arterial stiffness reproducible in patients with COPD?
### Response:
| The present study provides evidence for within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD. |
### Instruction:
Does long non-coding RNA UCA1 promote glutamine metabolism by targeting miR-16 in human bladder cancer?
### Response:
| Together, our results revealed that urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells. |
### Instruction:
Does hepatic resection margin predict survival in colorectal cancer with hepatic metastasis?
### Response:
| Hepatic resection provides a safe and effective treatment in patients with hepatic metastasis from colorectal cancer. In this study, only the surgical resection margin of the hepatic metastasis of colorectal cancer significantly predicted survival. |
### Instruction:
Does trail Making Test elucidate Neural Substrates of Specific Poststroke Executive Dysfunctions?
### Response:
| In this multinational stroke cohort study, damage to lateral cholinergic pathways and the superior longitudinal fasciculus emerged as significant neuroanatomical correlates for executive deficits in set shifting. |
### Instruction:
Is para-aortic workup in locally advanced cervical cancer : heterogeneity still the rule . Results from a retrospective multicenter study?
### Response:
| Despite established recommendations, our results point out the tremendous heterogeneity regarding para-aortic assessment. These differences in management are perhaps related to a recommended therapeutic strategy that does not appear to improve the poor prognosis associated with PA involvement. |
### Instruction:
Does ketoacid Supplementation Partially improve Metabolic Parameters in Patients on Peritoneal Dialysis?
### Response:
| Ketoacid therapy administered for 6 months had no effect on HOMA-IR but resulted in improvements in hs-CRP and LAR, suggesting metabolic benefit. Future studies are needed to confirm these results and any potential benefit in vascular health of PD patients. |
### Instruction:
Is risk prediction by genetic risk scores for coronary heart disease independent of self-reported family history?
### Response:
| The addition of 23 SNPs to an existing GRS27 improved CHD risk prediction and was independent of self-reported family history. Coronary heart disease risk assessment by GRS could be particularly useful in young individuals. |
### Instruction:
Does nrf2-driven CD36 and HO-1 gene expression in circulating monocytes correlate with favourable clinical outcome in pregnancy-associated malaria?
### Response:
| Altogether these results suggest that Nrf2-driven CD36 and HO-1 expression on innate immune cells could contribute to a protective and detoxifying mechanism during PAM. More powered and mechanistical studies are however needed to strengthen the conclusions of this study. |
### Instruction:
Is isoprene in the Exhaled Breath a Novel Biomarker for Advanced Fibrosis in Patients with Chronic Liver Disease : A Pilot Study?
### Response:
| Isoprene is a potential biomarker for advanced fibrosis that deserves further validation. |
### Instruction:
Do several Ryanodine Receptor Type 1 Gene Mutations of p.Arg2508 Are Potential Sources of Malignant Hyperthermia?
### Response:
| Any of these 4 mutations in RYR1 p.Arg2508 may cause important changes related to MH. Studying the effects of changes in amino acids at 2508 in RYR1 on the movement of this large protein may lead to a better understanding of the pathology of MH events. |
### Instruction:
Does menstrual blood contain immune cells with inflammatory and anti-inflammatory properties?
### Response:
| MB contains cells of an inflammatory and anti-inflammatory nature, implying the existence of finely tuned cell homeostasis during menstruation. Our results imply that MB could be viewed as an easy-to access specimen for monitoring endometrial immune cells, especially those that have preferential endometrial localizatio... |
### Instruction:
Does liraglutide treatment cause upregulation of adiponectin and downregulation of resistin in Chinese type 2 diabetes?
### Response:
| In Chinese T2DM patients, liraglutide treatment led to increased adiponectin and decreased resistin levels compared to glimepiride-treated subjects, while inducing similar glycemic changes. |
### Instruction:
Is overexpression of MMP13 in human osteoarthritic cartilage associated with the SMAD-independent TGF-β signalling pathway?
### Response:
| Our results demonstrate that MMP13 expression is associated with an increased expression of TGFB1 in OA-affected cartilage, possibly through SMAD-independent TGF-β pathway. Furthermore, TGF-β/SMAD3 is overactivated in OA cartilage; yet, the consequence of this overactivation remains to be established. |
### Instruction:
Is sequential Therapy Superior to Triple Therapy for Helicobacter pylori Infection in Children : A Meta-Analysis?
### Response:
| In children, sequential therapy appears to be superior to triple therapy for H. pylori eradication, although the eradication rates remain lower than the expected goal with both treatments. Factors-associated with a higher risk of eradication failure, such as compliance and antimicrobial resistance, remain insufficientl... |
### Instruction:
Do vitamin D levels predict hospitalization and mortality in patients with heart failure?
### Response:
| Vitamin D deficiency is highly prevalent in patients with HF, and low vitamin D levels are closely associated with increased hospitalisation and mortality. |
### Instruction:
Are apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms correlated with an increased risk of coronary heart disease : a case-control and meta-analysis study?
### Response:
| APOA5 -1131 T > C and APOC3 -455 T > C SNPs may play potent roles in the development and progression of CHD. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.