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### Instruction:
Is metabolome of human gut microbiome predictive of host dysbiosis?
### Response:
| Specific enzyme functions and metabolites predictive of dysbiosis provide insights into the molecular mechanisms of microbiome-host interactions. The ability to use machine learning to predict dysbiosis from microbiome community interaction data provides a potentially powerful tool for understanding the links between t... |
### Instruction:
Do synoptic operative reports enhance documentation of best practices for rectal cancer?
### Response:
| SR were associated with reliable and more complete and reliable documentation of items on the RCC. Use of an SR system standardizes operative reporting, providing the opportunity to enhance checklist compliance, and enable timely feedback to improve surgical outcomes for rectal cancer patients. |
### Instruction:
Is impaired cardiac autonomic nervous system function associated with pediatric hypertension independent of adiposity?
### Response:
| These data suggest that impaired cardiac autonomic nervous system function, at rest, is associated with higher odds of being prehypertensive/hypertensive and higher SBP which may be independent of adiposity in youth. |
### Instruction:
Does carbamazepine aggravate absence seizures in two dedicated mouse models?
### Response:
| CBZ aggravates absence seizures as assessed in two dedicated mouse models of absence seizures. Facilitation of sub-maximal α1β2γ2, and α3β2γ2 GABA currents by CBZ may play a role in CBZ-induced GABA-mediated aggravation of absence seizures. |
### Instruction:
Does dexmedetomidine protect from post-myocardial ischaemia reperfusion lung damage in diabetic rats?
### Response:
| Our results confirm that dexmedetomidine has protective effects against the lung damage resulting from I/R in diabetic rats. Future studies conducted to evaluate the effects of the use of dexmedetomidine on damage to various organs following different I/R durations may help understanding possible protective effects of ... |
### Instruction:
Does saxagliptin improve glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults ( LADA )?
### Response:
| Saxagliptin was effective in lowering blood glucose levels and generally well tolerated in GADA-positive patients. Interestingly, saxagliptin appears to improve β-cell function in these patients, although a longer treatment duration may be needed to confirm this finding. |
### Instruction:
Is high statistical heterogeneity more frequent in meta-analysis of continuous than binary outcomes?
### Response:
| Meta-analyses evaluating continuous outcomes showed substantially higher I(2) than meta-analyses of binary outcomes. Results suggest differing standards for interpreting I(2) in continuous vs. binary outcomes may be appropriate. |
### Instruction:
Does community outreach midwifery-led model improve antenatal access in a disadvantaged population?
### Response:
| There is a large disparity in maternal and child health outcomes between Aboriginal and Torres Strait Islander (Indigenous) and non-Indigenous Australians thought to be due to decreased access to antenatal care, poorer socioeconomic status and the associated risk factors. The change in model of care resulted in earlier... |
### Instruction:
Does extended 2D myotube culture recapitulate postnatal fibre type plasticity?
### Response:
| Our revised culture protocol allows the efficient differentiation and fusion of porcine myoblasts into myotubes and their prolonged adherence to the culture surface. Furthermore, we are able to recapitulate in 2D the maturation process of myotubes to resemble postnatal fibre types which represent a major technical adva... |
### Instruction:
Is basal ganglia pathology in ALS associated with neuropsychological deficits?
### Response:
| We demonstrate correlations between basal ganglia measures and structure-specific neuropsychological performance and a gradient of incremental basal ganglia pathology across the ALS-ALS-FTD spectrum, suggesting that the degree of subcortical gray matter pathology in C9orf72-negative ALS is closely associated with neuro... |
### Instruction:
Do jasmonates act positively in adventitious root formation in petunia cuttings?
### Response:
| Diminished numbers of AR in JA-deficient cuttings suggest that jasmonates act as positive regulators of AR formation in petunia wild type. However, wound-induced rise in jasmonate levels in petunia wild type cuttings seems not to be causal for increased auxin and ethylene levels and for sink establishment. |
### Instruction:
Does a Long Gastrojejunostomy be Associated With Decreased Incidence and Severity of Delayed Gastric Emptying After Pancreaticoduodenectomy?
### Response:
| This is the first study evaluating the effect of a long gastrojejunostomy on the incidence of DGE after PD. The LGPD is associated with significantly decreased DGE compared to SPD and PPPD and warrants further exploration as a means to improve outcome for patients who undergo PD. |
### Instruction:
Are assessments of Fatty Infiltration and Muscle Atrophy From a Single Magnetic Resonance Image Slice Predictive of 3-Dimensional Measurements?
### Response:
| Clinical scores using a single image slice do not represent 3-dimensional muscle measurements. Efficient methods are needed to more effectively capture 3-dimensional information for clinical applications. Participants with RCTs had increased fatty infiltration percentages that were likely driven by muscle atrophy rathe... |
### Instruction:
Do quality of life and hearing after cochlear implant placement in patients over 60 years of age?
### Response:
| The effectiveness of the cochlear implantation in patients with severe hearing loss after 60 years of age with respect to the quality of life and hearing was confirmed. Statistically significant improvement was demonstrated in the self-assessment of patients in relation to the speech understanding, spatial hearing and ... |
### Instruction:
Do dental composite components induce DNA-damage and altered nuclear morphology in gingiva fibroblasts?
### Response:
| The improved γ-H2AX/53BP1 focus assay revealed a concentration-dependent increase in DSBs for all tested substances. Furthermore, concentration-dependent changes in HGF cell nucleus morphology was noted, demonstrating genotoxic effects of the substances tested. |
### Instruction:
Does platelet to lymphocyte ratio play an important role in prostate cancer 's diagnosis and prognosis?
### Response:
| PLR is significantly increased in PCA patients, and it is an independent predictor of 3-year mortality in PCA patients. |
### Instruction:
Do serum Angiopoietin-Like Protein 2 Concentrations Are Independently Associated with Heart Failure?
### Response:
| Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation. |
### Instruction:
Do dietary restraint and impulsivity modulate neural responses to food in adolescents with obesity and healthy adolescents?
### Response:
| This first ERP study in adolescents with obesity and controls revealed impulsivity as a general risk factor in the current obesogenic environment by increasing food-cue salience. Dietary restraint showed paradoxical effects in patients, making them more vulnerable to visual food-cues. Salutogenic therapeutic approaches... |
### Instruction:
Is chlamydia trachomatis IgG3 seropositivity associated with gastroschisis?
### Response:
| Anti-CT IgG3 seropositivity was associated with greater than a threefold risk for gastroschisis. |
### Instruction:
Does chronotype modulate Language Processing-Related Cerebral Activity during Functional MRI ( fMRI )?
### Response:
| These findings reveal that even basic language processes are associated with chronotype-specific neuronal mechanisms. Consequently, results might change the way we schedule patient evaluations and/or healthy subjects in e.g. experimental research and adding "chronotype" as a statistical covariate. |
### Instruction:
Does up-regulation of A20/ABIN1 contribute to inefficient M1 macrophage polarization during Hepatitis C virus infection?
### Response:
| HCV antigens stimulation up-regulates A20/A20-binding inhibitor of NF-κB binding protein expression, which consequently contributes to inefficient M1 macrophage polarization. |
### Instruction:
Does progression of Common Variable Immunodeficiency Interstitial Lung Disease accompany Distinct Pulmonary and Laboratory Findings?
### Response:
| Interstitial lung disease resulted in physiological worsening in many, but not all subjects, and was associated with suboptimal immunoglobulin G replacement. Those with worsening pulmonary function tests, elevated IgM, and severe thrombocytopenic episodes appear to be at highest risk for progressive disease. Such patie... |
### Instruction:
Is endoplasmic reticulum stress involved in apoptosis of detrusor muscle in streptozocin-induced diabetic rats?
### Response:
| The occurrence of ERS-associated apoptosis may be involved in the development of DCP and may contribute to the diabetic detrusor impairment. Neurourol. Urodynam. 9999:XX-XX, 2015. © 2015 Wiley Periodicals, Inc. |
### Instruction:
Does cis-regulatory analysis of the Drosophila pdm locus reveal a diversity of neural enhancers?
### Response:
| These studies reveal a diversity of modular enhancers that most likely regulate pdm gene expression during embryonic and adult development, highlighting a high level of temporal and spatial expression specificity. In addition, we discovered clusters of functionally related enhancers throughout the pdm locus. A subset o... |
### Instruction:
Does dipeptidyl peptidase-4 inhibition attenuate arrhythmias via a protein kinase A-dependent pathway in infarcted hearts?
### Response:
| Sitagliptin protects ventricular arrhythmias by attenuating NGF-induced sympathetic innervation via upregulation ofHO-1expression in a cAMP/PKA/CREB-dependent antioxidant pathway in non-diabetic infarcted rats. |
### Instruction:
Are variant of the clock circadian regulator ( CLOCK ) gene and related haplotypes associated with the prevalence of type 2 diabetes in the Japanese population?
### Response:
| Variant of the CLOCK gene and related haplotypes are associated with the prevalence of T2D in the Japanese population, in which obesity is less common, and the association between CLOCK gene variant at rs1801260 and the prevalence of diabetes is enhanced in normal-weight subjects. |
### Instruction:
Does adoptive transfer of immune cells from glaucomatous mice provoke retinal ganglion cell loss in recipients?
### Response:
| This study demonstrates that the pathophysiology of glaucomatous degeneration in the tested animal models includes T-cell mediated events that are capable of causing loss of healthy retinal ganglion cells. |
### Instruction:
Does transvitreal Retinochoroidal Biopsy provide a Representative Sample From Choroidal Melanoma for Detection of Chromosome 3 Aberrations?
### Response:
| Regardless of genetic heterogeneity, the TVRC biopsy identified all patients with a high risk of developing metastatic disease when a combination of chromosome 3 and 8 status was assessed. |
### Instruction:
Does vitamin D protect Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine?
### Response:
| VD protects against atherosclerosis in hypercholesterolemic swine via controlling cholesterol efflux and macrophage polarization via increased CYP27A1 activation. |
### Instruction:
Does gaseous ammonia pretreatment lower the required energy input for fine milling-enhanced enzymatic saccharification of switchgrass?
### Response:
| The combination of knife milling, low moisture gaseous ammonia pretreatment followed by attritor milling that costs only ~5 % of the energy content of the biomass for a total energy input of ~11 % of the biomass energy content, is capable of delivering high sugar titers upon enzymatic saccharification. These results sh... |
### Instruction:
Is injury severity at presentation associated with long-term vocational outcome in British Military brain injury?
### Response:
| ISS/GCS at the point of injury does not reflect eventual outcome. IEDs/gunshots cause the greatest number of injuries and the highest incidence of brain injury. Brain injury should be considered in every battlefield casualty, irrespective of whether the head/neck/spinal cord was avoided. ISS should not be considered in... |
### Instruction:
Does leucoreduction help to preserve activity of antioxidant barrier enzymes in stored red blood cell concentrates?
### Response:
| Leucoreduction of RBC before storage helps to preserve the activity of antioxidant barrier enzymes in stored RBCs and significantly improves the quality of stored red blood cell components. |
### Instruction:
Is non-structural protein NS3/NS3a required for propagation of bluetongue virus in Culicoides sonorensis?
### Response:
| The lack of viremia and the inability to replicate within the vector, clearly demonstrate the inability of NS3/NS3a knockout DISA vaccine strains to be transmitted by midges. |
### Instruction:
Is spontaneous phenotypic suppression of GacA-defective Vibrio fischeri achieved via mutation of csrA and ihfA?
### Response:
| In addition to its established role in regulation of central metabolism, the CsrA regulator represses luminescence and siderophore as an intermediate of the GacA regulatory hierachy. Siderophore regulation was less sensitive to stoichiometry of CsrA consistent with higher affinity for the targets of this trait. The lac... |
### Instruction:
Does a dose-response meta-analysis reveal an association between vitamin B12 and colorectal cancer risk?
### Response:
| Our meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only. |
### Instruction:
Does hLA-E regulate NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire?
### Response:
| in contrast to NKG2A, NKG2C is regulated by HLA-E only when HLA-E is in complex with a restricted peptide repertoire, especially in combination with the HLA-G leader peptide. |
### Instruction:
Are in chordoma , metastasis , recurrences , Ki-67 index , and a matrix-poor phenotype associated with patients ' shorter overall survival?
### Response:
| We propose to include these parameters in the final pathologic report of the resected chordoma. |
### Instruction:
Does mCT4 surpass the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma?
### Response:
| Prognostic significance of CD147 protein expression could not surpass that of MCT4, especially of SLC16A3 DNA methylation, corroborating the role of MCT4 as prognostic biomarker for ccRCC. |
### Instruction:
Does gSK-3β regulate tumor growth and angiogenesis in human glioma cells?
### Response:
| These results reveal that GSK-3β regulates mTOR/p70S6K1 signaling pathway and inhibits glioma progression in vivo; its inactivation via p-GSK-3β (Ser9) is associated with glioma development, which is new mechanism that may be helpful in developing GSK-3β-based treatment of glioma in the future. |
### Instruction:
Does circadian clock gene play a key role on ovarian cycle and spontaneous abortion?
### Response:
| Collectively, theses findings indicate that CLOCK plays an important role in fertility and that the CLOCK knockdown leads to reduction in reproduction and increased miscarriage risk. |
### Instruction:
Is coffee consumption associated with increased risk of atrial fibrillation : results from two prospective cohorts and a meta-analysis?
### Response:
| We found no evidence that coffee consumption is associated with increased risk of AF. |
### Instruction:
Does hypothalamic stearoyl-CoA desaturase-2 ( SCD2 ) control whole-body energy expenditure?
### Response:
| Thus, SCD2 is highly expressed in the hypothalami of rodents and its knockdown reduces body mass due to increased whole-body energy expenditure. |
### Instruction:
Is clinician empathy associated with differences in patient-clinician communication behaviors and higher medication self-efficacy in HIV care?
### Response:
| Clinician empathy may be expressed through addressing patient engagement in care, by fostering cognitive, rather than primarily emotional, processing. |
### Instruction:
Does elevated protein arginine methyltransferase 1 expression regulate fibroblast motility in pulmonary fibrosis?
### Response:
| PRMT1 can contribute to the development of pulmonary fibrosis by regulating fibroblast activities. Thus, interference with its expression and/or activity may provide a novel therapeutic option for patients with IPF. |
### Instruction:
Is kupffer phase image of Sonazoid-enhanced US useful in predicting a hypervascularization of non-hypervascular hypointense hepatic lesions detected on Gd-EOB-DTPA-enhanced MRI : a multicenter retrospective study?
### Response:
| Kupffer-phase images in Sonazoid-enhanced US and tumor diameter can predict hypervascularization of hypointense borderline lesions detected on hepatobiliary-phase Gd-EOB-DTPA-enhanced MRI. |
### Instruction:
Does diffuse reflectance spectroscopy accurately quantify various degrees of liver steatosis in murine models of fatty liver disease?
### Response:
| DRS can quantify steatosis with good agreement to histopathological analysis. DRS may be useful for real-time objective evaluation of liver steatosis during liver transplantation, especially to differentiate between mild and moderate/severe steatosis. |
### Instruction:
Do inadequate hepcidin serum concentrations predict incident type 2 diabetes mellitus?
### Response:
| Hepcidin levels that are inadequately low in relation to body iron stores are an independent predictor for incident T2DM and may contribute to diabetes-related tissue iron overload. Copyright © 2015 John Wiley & Sons, Ltd. |
### Instruction:
Does naCl concentration in the medium modulate the secretion of active EmpA protease in Vibrio anguillarum at post-transcriptional level?
### Response:
| The NaCl concentration in the medium modulates the secretion of active EmpA protease in V. anguillarum at a post-transcriptional level. |
### Instruction:
Do abnormal frontal theta oscillations underlie the cognitive flexibility deficits in children with high-functioning autism spectrum disorders?
### Response:
| Our findings suggest that abnormal activations of multiple cortical regions, especially the frontal lobe, form the neural basis of the cognitive flexibility deficits in children with ASD. In addition, we found an EEG marker of cognitive flexibility which could be used to monitor treatment outcomes objectively. |
### Instruction:
Does local injury to the endometrium improve the implantation rate in good responder patients undergoing in-vitro fertilization?
### Response:
| In our study, endometrial biopsy didn't increase the chances to conceive at the following cycle of treatment. |
### Instruction:
Does 'Deepness of Response ' Is associate with Overall Survival in Standard Systemic Chemotherapy for Metastatic Colorectal Cancer?
### Response:
| DpR correlated with OS in various first-line systemic upfront chemotherapy regimens for mCRC. |
### Instruction:
Does delta-slope of alpha-fetoprotein improve the ability to select liver transplant patients with hepatocellular cancer?
### Response:
| Integration of the AFP delta-slope with conventional criteria may further improve patient selection and post-LT outcomes; prospective studies are needed to validate the present proposed model. |
### Instruction:
Does the progression of thyroid cartilage calcification as it relate to the utilization of laryngeal ultrasound?
### Response:
| The thyroid cartilage calcifies at a rate that is significantly related to increasing age and calcifies in a posterolateral to anteromedial direction. Based on the HU, the thyroid cartilage is not consistently denser than soft tissue until greater than 40 years of age, which would make laryngeal ultrasound feasible for... |
### Instruction:
Does hybrid de novo tandem repeat detection using short and long read?
### Response:
| Our method shows high precision and sensitivity. With low false positive rates even for highly erroneous reads, MixTaR is able to detect accurate tandem repeats with pattern lengths varying within a significant interval. |
### Instruction:
Do a number of factors explain why WHO guideline developers make strong recommendations inconsistent with GRADE guidance?
### Response:
| WHO panelists make discordant recommendations inconsistent with GRADE guidance for reasons that include limitations in their understanding of GRADE. Ensuring optimal application of GRADE at WHO and elsewhere likely requires selecting panelists who have a commitment to GRADE principles, additional training of panelists,... |
### Instruction:
Does activation of Src-dependent Smad3 signaling mediate the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury?
### Response:
| Our data suggest that hyperoxia-increased high-tidal-volume ventilation-induced ALI partially depends on the Src and Smad3 pathways. |
### Instruction:
Does acute Alcohol Intoxication aggravate Brain Injury Caused by Intracerebral Hemorrhage in Rats?
### Response:
| This is a novel model to evaluate the effects of high-dose alcohol administration on experimental ICH rats. |
### Instruction:
Does pyruvate Kinase Muscle Isoenzyme 2 ( PKM2 ) Expression be Associated with Overall Survival in Pancreatic Ductal Adenocarcinoma?
### Response:
| PKM2 expression is associated with overall survival in PDAC. Further studies are warranted to validate the value of PKM2 as a prognostic biomarker and to examine the potential utility of PKM2 in predicting treatment response, as well as a potential therapeutic target in PDAC. |
### Instruction:
Does health-related quality of life predict unplanned rehospitalization following coronary revascularization?
### Response:
| Poor HRQL assessed after coronary revascularization appears to be a powerful predictor of rehospitalization over a 3-year period. |
### Instruction:
Does acute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice be REDD-1 and mTOR-Independent?
### Response:
| REDD1 does not appear to play a role in the acute alcohol-mediated decrease in protein synthesis or mTOR activity, but may contribute to the regulation of ubiquitin-proteasome mediated protein breakdown. |
### Instruction:
Does pretreatment with magnesium ameliorate lipopolysaccharide-induced liver injury in mice?
### Response:
| Pretreatment with Mg protects the liver from the acute injury which occurs shortly after septicemia. |
### Instruction:
Is iL-17A implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation?
### Response:
| Taken together, our results suggest that IL-17A was involved in LPS-induced neuroinflammation and cognitive impairment in aged rats via microglial activation. Anti-IL-17A may represent a new therapeutic strategy for the treatment of endotoxemia-induced neuroinflammation and cognitive dysfunction. |
### Instruction:
Is akt2 and p-Akt overexpression in oral cancer cells due to a reduced rate of protein degradation?
### Response:
| Both Akt2 and p-Akt were overexpressed in oral cancer cells, which may be partly explained by a reduced rate of protein degradation in order to maintain high cytosolic levels. |
### Instruction:
Does interferon-γ-mediated allograft rejection exacerbate cardiovascular disease of hyperlipidemic murine transplant recipients?
### Response:
| Our study reveals that sustained activation of the immune system because of chronic allorecognition exacerbates the atherogenic diathesis of hyperlipidemia and results in de novo cardiovascular dysfunction in organ transplant recipients. |
### Instruction:
Does differential response to endothelial epithelial sodium channel inhibition ex vivo correlate with arterial stiffness in humans?
### Response:
| Here, we report differential responses of human ex-vivo vessels to amiloride. Although the mechanism of differential amiloride response is still unknown, the data indicate that drug action on endothelial function could differ strongly among patients, especially in those with a vascular end-organ damage determined by PW... |
### Instruction:
Do integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity?
### Response:
| Our data indicate that reduced methylation of the CIB2 promoter in individuals carrying rs7164338 may lead to increased CIB2 expression. Given that CIB2 is thought to regulate intracellular calcium levels, an increase in protein levels may prevent the accumulation of serum calcium and phosphate, ultimately slowing down... |
### Instruction:
Is peripheral nerve diffusion tensor imaging reliable and reproducible?
### Response:
| We found peripheral nerve DTI to be reliable and reproducible, with few effects related to the postprocessing package used. |
### Instruction:
Does apolipoprotein-J prevent angiotensin II-induced apoptosis in neonatal rat ventricular cells?
### Response:
| ApoJ serves as a cytoprotective protein in NRVCs against cytotoxicity of AngII through the PI3K-Akt-ROS and MAPK/ NF-κB pathways. |
### Instruction:
Does significant Incidence of Extra-Articular Tibia Vara affect Radiological Outcome of Total Knee Arthroplasty?
### Response:
| A significant inherent extra-articular varus angulation best measured using MDA exists in the proximal tibia in osteoarthritic Indian patients undergoing TKA. MDA of >4° is associated with abnormal postoperative HKA. Computer navigation may be useful for achieving ideal correction in such cases. |
### Instruction:
Is the PI3K/AKT cell signaling pathway involved in regulation of osteoporosis?
### Response:
| The in vivo and in vitro studies indicated that the PI3K/Akt cell signaling pathway is involved in the inhibition of osteoporosis through promoting osteoblast proliferation, differentiation and bone formation. |
### Instruction:
Is abnormal distribution of AQP5 in labial salivary glands associated with poor saliva secretion in patients with Sjögren 's syndrome including neuromyelitis optica complicated patients?
### Response:
| Our results suggest that AQP5 but not AQP4 contributes to salivary secretion in patients with SS including those with NMO complicated with SS. |
### Instruction:
Is regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 determined by 5 ' splice site strength?
### Response:
| Competition for PRPF8 availability alters the transcription-coupled splicing of RNAs in which weak 5' splice sites predominate, enabling diversification of human gene expression during biological processes like mitosis. Our findings exemplify the regulatory potential of changes in the core spliceosome machinery, which ... |
### Instruction:
Does bDNF Val66Met Polymorphism be Related to Motor System Function After Stroke?
### Response:
| The extent to which these findings generalize to other populations of people with stroke, such as those with stroke <7 days prior, remains uncertain. |
### Instruction:
Does prevalence and correlate of metabolic syndrome and its components in elderly Korean adults?
### Response:
| The results indicated that the prevalence of metabolic syndrome in elderly Korean adults was high, suggesting that the prevention and management of metabolic syndrome in the elderly should be addressed via individual components. |
### Instruction:
Does inclusion of homologous DNA in nuclease-mediated gene targeting facilitate a higher incidence of bi-allelically modified cells?
### Response:
| The approach of using donor DNA in conjunction with a meganuclease can be used to increase the efficiency of gene targeting. The gene editing methods can be applied to other genes as well as other mammalian systems. Additionally, gene expression analysis further confirms that the CMAH/GGTA1 double KO pigs can be a valu... |
### Instruction:
Does a novel fibrinogenase from Agkistrodon acutus venom protect against LPS-induced endotoxemia via regulating NF-κB pathway?
### Response:
| Our findings suggested that FII had protective effect on LPS-induced endotoxemia and organ injuries by suppressing the activation of NF-κB which decreased TNF-α level. |
### Instruction:
Does alpha-Synuclein produce Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit?
### Response:
| We suggest that striatal cholinergic dysfunction, induced by a direct interaction between α-syn and GluN2D-expressing N-methyl-D-aspartate receptors, represents a precocious biological marker of the disease. |
### Instruction:
Does ellagic acid improve electrocardiogram waves and blood pressure against global cerebral ischemia rat experimental models?
### Response:
| Results indicate that global cerebral ischemia-reperfusion impairs certain heart functions and ellagic acid as an antioxidant can restore these parameters. The results of this study suggest the possible utility of ellagic acid in patients with brain stroke. |
### Instruction:
Do glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells?
### Response:
| These results indicate that POAG-causing MYOC mutants activate the IL-1/NF-κB pathway, with activation levels correlated with intracellular retention of the protein, but not POAG-causing potency. Unexpectedly, it was also discovered that wild-type MYOC inhibits activation of the IL-1/NF-κB pathway, and that activation ... |
### Instruction:
Does maternal inheritance predict cholesterol levels in children with familial hypercholesterolemia?
### Response:
| Maternal inheritance of FH was not associated with detectable long-term effects in the offspring's phenotype measured by adverse lipid profiles and increased CRP levels, whereas a LDL receptor negative mutation was associated with an unfavorably phenotype in FH offspring. Our findings do not support the fetal origin of... |
### Instruction:
Does effect of benzene extract of Ocimum sanctum leave on cauda epididymal spermatozoa of rats?
### Response:
| The effects observed in this study may have resulted from a general alteration in the cauda epididymal milieu, probably due to androgen deficiency consequent to the anti-androgenic property of O.sanctum leaves. |
### Instruction:
Does icodextrin reduce adhesion formation following gynecological surgery in rabbits?
### Response:
| The use of 4% icodextrin solution was more effective than human amniotic fluid and sterile water in reducing adhesion formation in a gynecological surgery model in rabbits. |
### Instruction:
Does outcome of in-patient fall in hospitals with 100 % single rooms and multi-bedded wards?
### Response:
| This observational study shows a significantly increased incidence of falls and fracture in a hospital design with SRs compared with a multi-bedded facility. Consideration should be given to increased incidence of falls and falls-related injury in SRs when deciding on the percentage of single-room provision in new hosp... |
### Instruction:
Does rbAp48 be Critical for the Proliferation of Hypopharyngeal Carcinoma?
### Response:
| RbAp48 was identified as critical in the proliferation of hypopharyngeal carcinoma in both in vitro and in vivo experiments. It is conceivable that the regulation of tumor suppressors (Bcl-2 family and caspase enzymes) by RbAp48 contributes, at least in part, to the RbAp48-mediated proliferation in hypopharyngeal carci... |
### Instruction:
Is chronic lymphocytic thyroiditis associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents?
### Response:
| Children and adolescents with CLT present more frequently familial PTC as well as thyroid cancer with invasive characteristics. |
### Instruction:
Is nighttime kidney transplantation associated with less pure technical graft failure?
### Response:
| Limitation of this study is mainly to its retrospective design, and the influence of some relevant variables, such as the experience level of the surgeon, could not be assessed. We conclude that nighttime surgery is associated with less pure technical graft failures. Further research is required to explore factors that... |
### Instruction:
Are platelet activating factors associated with depressive symptoms in coronary artery disease patients : a hypothesis-generating study?
### Response:
| These preliminary findings support the exploration of the PAF lipidome for depressive symptom biomarkers in CAD patients. Patients were recruited as part of the following clinical trial: NCT00981383. |
### Instruction:
Is an intact helical domain required for Gα14 to stimulate phospholipase Cβ?
### Response:
| Collectively, our study suggests that the previously identified PLCβ-interacting residues are insufficient to ensure productive interaction of Gα14 with PLCβ, while an intact N-terminal half of Gα14 is apparently required for PLCβ interaction. |
### Instruction:
Does fragmented QRS on Admission Electrocardiography predict Long-Term Mortality in Patients with Non-ST-Segment Elevation Myocardial Infarction?
### Response:
| We found a relation between fQRS and late mortality. Fragmented QRS may be seen as a cautionary signal for extensive myocardial damage and thereby increased long-term mortality for patients with NSTEMI. |
### Instruction:
Is phytoestrogenic activity of blackcurrant ( Ribes nigrum ) anthocyanins mediated through estrogen receptor alpha?
### Response:
| These results suggest that blackcurrant anthocyanins act as phytoestrogens in vitro and in vivo. |
### Instruction:
Does weekend Admission for Acute Cholangitis Adversely Impact Clinical or Endoscopic Outcomes?
### Response:
| Weekend admission and weekend ERC do not negatively impact outcomes of patients hospitalized with acute cholangitis at a tertiary care center. Further studies, particularly in centers with less weekend resources or staffing, are indicated. |
### Instruction:
Does human papillomavirus DNA in pharyngeal scrape as a marker of HPV-related squamous cell cancer of the oropharynx?
### Response:
| The proposed novel method of HPV status assessment using RT-PCR and superficial scraps appeared to be highly sensitive, specific, and useful in predicting the clinical outcome. |
### Instruction:
Does loss of ACSS2 expression predict poor prognosis in patients with gastric cancer?
### Response:
| We revealed that the loss of ACSS2 expression is a reliable independent poor prognostic factor in GC. Our results may expand our understanding of the involvement of glucose metabolism, including the role of ACSS2, in the pathogenesis of GC. |
### Instruction:
Does loss of Gsα impair liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling?
### Response:
| The growth factor signaling pathway that promotes hepatocyte proliferation is dependent on Gsα signaling. Loss of Gsα leads to a breakdown of the crosstalk between cAMP and growth factor signaling and dramatically impairs liver regeneration. |
### Instruction:
Does vitamin D deficiency exacerbate COPD-like characteristics in the lungs of cigarette smoke-exposed mice?
### Response:
| Our data demonstrate that vitamin D deficiency both accelerates and aggravates the development of characteristic disease features of COPD. As vitamin D deficiency is highly prevalent, large randomized trials exploring effects of vitamin D supplementation on lung function decline and COPD onset are needed. |
### Instruction:
Does hsp27 act as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular Carcinoma Progression?
### Response:
| Hsp27 along with its co-chaperones was related to the development of HCC by regulating multiple signaling pathways, and drugs that target Hsp27 along with its co-chaperones may be a potential therapy for HCC. |
### Instruction:
Does inhibition of Survival Pathways MAPK and NF-kB trigger Apoptosis in Pancreatic Ductal Adenocarcinoma Cells via Suppression of Autophagy?
### Response:
| Here we present evidence that allows us to consider a combined therapy regimen comprising an autophagy inhibitor and a MAPK or NF-kB pathway inhibitor as a possible treatment strategy for pancreatic cancer. |
### Instruction:
Does budesonide Foam have a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis?
### Response:
| This integrated analysis demonstrated that budesonide foam for the induction of remission of distal ulcerative colitis is safe overall, with no clinically relevant effects on the hypothalamic-pituitary-adrenal axis. |
### Instruction:
Does clinical outcome and long term result after surgical treatment of biliary cystadenoma and cystadenocarcinoma?
### Response:
| Preoperative differentiations of BCA from simple cyst, and BCCA from BCA are still difficult. Complete removal of the tumor, via major hepatectomy, should be considered, especially in the younger age group with large tumor. |
### Instruction:
Does down-regulation of miR-186 contribute to podocytes apoptosis in membranous nephropathy?
### Response:
| We revealed that TLR4 is involved in the regulation of miR-186 expression, and the anti-apoptotic effect of miR-186 on podocytes is correlated with P2×7 regulation. |
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