question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does non-pregnant circulatory volume status predict subsequent pregnancy outcome in normotensive thrombophilic formerly preeclamptic women?
### Response:
| Pre-pregnant plasma volume in normotensive thrombophilic formerly preeclamptic women have predictive value with respect to hypertensive complications in the subsequent pregnancy. |
### Instruction:
Does food influence the pharmacokinetics of a new extended release formulation of tolterodine for once daily treatment of patients with overactive bladder?
### Response:
| The new ER formulation of tolterodine shows no pharmacokinetic interaction with food. On the basis of these results, patients with overactive bladder may, therefore, be advised to take the drug without regard to the timing of meals, maximising convenience during therapy. |
### Instruction:
Are haemodynamic changes and vasopressin release consistently associated with carbon dioxide pneumoperitoneum in humans?
### Response:
| Continuous adequate depth of anaesthesia and normovolaemia may have prevented both a humoral and a haemodynamic response, initiated in the peritoneum by the contact with CO2 in previous investigations. |
### Instruction:
Do human recombinant interferon-alpha2a and interferon-alphaA/D have different effects on bleomycin-induced lung injury?
### Response:
| IFN-alpha may enhance Bleo-induced lung injury but this effect varies with different IFN preparations. |
### Instruction:
Does notch signaling target the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila?
### Response:
| Our results show that, in Drosophila, an activity of Notch that is likely to be independent of Su(H) inhibits Wingless signaling on Ubx(VM)B. A possible target of this activity is dTcf. As dTcf has been shown to be capable of repressing Wingless targets, our results suggest that this repressive activity may be regulated by Notch. Finally, we suggest that Wingless signaling is composed of two steps, a down-regulation of a Su(H)-independent Notch activity that modulates the activity of dTcf and a canonical Wingless signaling event that regulates the activity of Armadillo and its interaction with dTcf. |
### Instruction:
Does a novel pathway of cellular phosphatidylinositol ( 3,4,5 ) -trisphosphate synthesis is regulate by oxidative stress?
### Response:
| We describe for the first time a novel in vivo activity for Type Ialpha PIPkinase, and a novel pathway for the in vivo synthesis of functional PtdIns(3,4,5)P(3), a key lipid second messenger regulating a number of diverse cellular processes. |
### Instruction:
Does nocturnal body core temperature fall in Parkinson 's disease but not in Multiple-System Atrophy?
### Response:
| The physiological nocturnal fall of BcT degrees is blunted in MSA patients mainly because BcT degrees did not decrease during sleep. This CRT degrees pattern is not justified by differences in sleep structure and may reflect an impairment of central sympathetic nervous system function. |
### Instruction:
Are early puberty and early sexual activity associated with bulimic-type eating pathology in middle adolescence?
### Response:
| To prevent bulimia nervosa and to create opportunities for early intervention, attention should be paid to early maturing girls and off-time maturing boys, as well as those with early onset of sexual activity. |
### Instruction:
Are factors associated with medicine use and self medication different in adolescents?
### Response:
| The data from this study demonstrate a high prevalence of medicine use and self medication; however, the variables associated with medicine use and self medication differed. Urgent strategies to promote the rational use of drugs in this population and their families are necessary. |
### Instruction:
Is viral clearance associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3?
### Response:
| SVR is associated with a reduction in HOMA-IR in patients with HCV genotype 1 but not in those with genotype 2/3. Genotype 1 may have a direct effect on the development of IR, independent of host metabolic factors, and may be partially reversed by viral eradication. |
### Instruction:
Are physicians a key to encouraging cessation of smoking among people living with HIV/AIDS : a cross-sectional study in the Kathmandu Valley , Nepal?
### Response:
| Roughly one-third of HIV-positive smokers residing in the Kathmandu Valley, Nepal, are at the contemplation or preparation stage of smoking behaviour change, with rates significantly higher among those whose physicians have asked about their smoking status during any clinical interaction over the past year. Systematic screening for smoking by physicians during routine HIV care may help to reduce the heavy burden of smoking and smoking-related morbidity and mortality within HIV-positive populations in Nepal and similar settings. |
### Instruction:
Is albumin-induced apoptosis of glomerular parietal epithelial cells modulated by extracellular signal-regulated kinase 1/2?
### Response:
| A normal role of PECs is to take up filtered albumin. However, this is increased in proteinuric glomerular diseases, leading to apoptosis through changes in ERK1/2. |
### Instruction:
Is myocardial performance reduced immediately prior to ventricular ectopy?
### Response:
| Ventricular ectopy is preceded by a significant decrease in myocardial performance in the last sinus beat preceding VPBs as observed in consecutive patients with a broad variety of heart conditions pointing to a mutual underlying electrical mechanism (ie, localized conduction block confined to an area surrounding the ectopic pacemaker). |
### Instruction:
Does prophylactic intra-aortic balloon pump reduce C-reactive protein levels and early mortality in high-risk patients undergoing percutaneous coronary intervention?
### Response:
| The use of a prophylactic IABP in high-risk patients before PCI could reduce the CRP level and reduce mortality during the early phase following PCI. |
### Instruction:
Does inhibition of histidine decarboxylase ablate the autocrine tumorigenic effects of histamine in human cholangiocarcinoma?
### Response:
| The novel concept that an autocrine loop (consisting of enhanced histamine synthesis by HDC) sustains cholangiocarcinoma growth is proposed. Drug targeting of HDC may be important for treatment of patients with cholangiocarcinoma. |
### Instruction:
Does proteomic analysis of intra-arterial thrombus secretions reveal a negative association of clusterin and thrombospondin-1 with abdominal aortic aneurysm?
### Response:
| This proteomic analysis has identified a group of proteins concentrated in AAA ILT. Assessment of circulating concentrations of two representative polypeptides suggests for the first time that the ILT selectively sequesters proteins rather than actively releasing them. Further work is required to assess the mechanisms underpinning this observation and the associated clinical implications. |
### Instruction:
Is auditory novelty processing enhanced in obsessive-compulsive disorder?
### Response:
| It is suggested that the novelty P3 amplitude increase in OCD patients represents a physiological indicator of an enhanced cortical orienting response implicating stronger involuntary shifts of attention. This characteristic is driven by novelty per se and not moderated by potential threat of upcoming events. |
### Instruction:
Are sleep disturbances related to decreased transmission of blue light to the retina caused by lens yellowing?
### Response:
| Filtration of blue light by the aging lens was significantly associated with an increased risk of sleep disturbances. We propose that this is a result of disturbance of photoentrainment of circadian rhythms. |
### Instruction:
Does transcapsular arterial neovascularization after liver transplantation in pediatric patients indicate transplant failure?
### Response:
| Transcapsular arterial neovascularization, detected with color Doppler US, occurred in 9.5% (13 of 137) of pediatric patients and 8.4% (13 of 155) of liver transplants and was associated with underlying malperfusion and inflammation. The diagnosis of transcapsular arterial neovascularization was associated with reduced graft survival times and a high retransplantation rate. The negative prognostic value of the sign may assist in a strategy of organ allocation. |
### Instruction:
Does strength training with blood flow restriction diminish myostatin gene expression?
### Response:
| We concluded that LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. |
### Instruction:
Does treatment of metabolic syndrome slow progression of diabetic nephropathy?
### Response:
| Metabolic syndrome treatment and control are independently associated with a lesser progression of DN. |
### Instruction:
Is the waist circumference of risk in black South african men lower than in men of European ancestry?
### Response:
| For black South African diabetic men, CVD risk substantially increased with waist circumference >90 cm. The waist circumference cut point of >94 cm has the potential to misclassify many black South African diabetic men at risk for CVD. |
### Instruction:
Are genetic variants in MARCO associated with the susceptibility to pulmonary tuberculosis in Chinese Han population?
### Response:
| Our study suggested that genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population, and the findings emphasize the importance of MARCO mediated immune responses in the pathogenesis of tuberculosis. |
### Instruction:
Is human equilibrative nucleoside transporter 1 expression a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy?
### Response:
| The hENT1 expression in pancreatic adenocarcinoma strongly influences the outcome of preoperative Gem-CRT treatment. This biomarker could become a useful predictor of therapeutic effect for gemcitabine-based therapy in pancreatic cancer patients. |
### Instruction:
Does topical application of L-arginine block advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice?
### Response:
| L-Arginine when applied both orally and topically is a potent and broad suppressor of advanced ascorbylation in the lens. Its uptake in rabbit lens upon topical application suggests transcorneal uptake into the human lens should be feasible for testing its potential anticataract properties in clinical trials. |
### Instruction:
Does mobile phone emission modulate event-related desynchronization of α rhythms and cognitive-motor performance in healthy humans?
### Response:
| These results suggest that the peak amplitude of alpha ERD and the reaction time to the go stimuli are modulated by the effect of the GSM-EMFs on the cortical activity. |
### Instruction:
Do hLA-B57 and gender influence the occurrence of tuberculosis in HIV infected people of south India?
### Response:
| This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males. |
### Instruction:
Does cCK stimulation of GLP-1 neurons involve α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs?
### Response:
| CCK activates NTS-PPG cells by a circuit involving adrenergic and glutamatergic neurons. NTS-PPG neurons integrate a variety of peripheral signals that indicate both long-term energy balance and short-term nutritional and digestional status to produce an output signal to feeding and autonomic circuits. |
### Instruction:
Are increased Vitamin B12 levels associated with mortality in critically ill medical patients?
### Response:
| Our data show that high serum Vitamin B12 levels are associated with increased mortality in critically ill medical patients. We suggest that Vitamin B12 levels should be included in the work-up of all medical intensive care patients, particularly those with a chronic health history and increased severity of illness. |
### Instruction:
Does use of drospirenone/ethinyl estradiol ( DRSP/EE ) among women with acne reduce acne treatment-related resources?
### Response:
| The study was retrospective in design and had a limited follow-up period. Database limitations restricted assessment of medication compliance and adherence. |
### Instruction:
Does oral contraception enhance growth hormone responsiveness to hyper- and hypoglycaemia?
### Response:
| Healthy women on oral contraceptive treatment display an increased responsiveness of growth hormone to hypoglycaemic, as well as hyperglycaemic conditions and generally higher serum growth hormone concentrations than women without oral contraceptives. Given the known boosting effects of growth hormone on hypoglycaemic hormonal counter-regulation, oral contraceptives may thus be a pharmacological candidate contributing to combat hypoglycaemia unawareness in women with diabetes in the future. |
### Instruction:
Is socioeconomic status an independent predictor of biochemical recurrence among patients with prostate cancer who undergo radical prostatectomy?
### Response:
| Patients with low SES were older, presented more aggressive PCa characteristics and a high rate of disease recurrence. A low SES constituted an independent predictor for disease recurrence. |
### Instruction:
Does bMP9 inhibit the proliferation and invasiveness of breast cancer cells MDA-MB-231?
### Response:
| Decreased BMP9 expression is associated with the elevated proliferation and migration of human breast cancer. BMP9 can inhibit the growth, invasion, and migration of breast cancer cells in vitro and in vivo. BMP9 is a putative tumor suppressor in breast cancer. |
### Instruction:
Is mediobasal hypothalamic SIRT1 essential for resveratrol 's effects on insulin action in rats?
### Response:
| Taken together, these studies demonstrate that resveratrol improves glucose homeostasis mainly through a central SIRT1-dependent pathway and that the MBH is a major site of resveratrol action. |
### Instruction:
Do in vivo bone response and interfacial properties of titanium-alloy implant with different designs in rabbit model with time?
### Response:
| From the physico-chemical and biomechanical observations, it was found that that smooth type implants were well accepted in the physiological condition although chances of elemental leaching from the surface were also observed. Increase of the surface roughness can help into the formation of physico-chemical bondage with the surrounding hard tissues. |
### Instruction:
Is alcohol dependence related to overall internalizing psychopathology load rather than to particular internalizing disorders : evidence from a national sample?
### Response:
| The components of internalizing psychopathology that are associated with alcohol dependence are shared and cumulative among common anxiety and depressive disorders. These findings have the potential to influence clinical and scientific conceptualizations of the association between alcohol dependence and internalizing psychopathology. |
### Instruction:
Does roux-en-Y gastric bypass improve hepatic mitochondrial function in obese rats?
### Response:
| Diet-induced fatty liver is associated with mitochondrial dysfunction. RYGB increases COX-II, which is involved in mitochondrial respiration, and increases the nuclear translocation of the Nrf2 transcriptional factor, which is involved in mitochondrial biogenesis and function. Taken together, these data suggest that surgically induced weight loss is associated with improved mitochondrial function in obese rats. |
### Instruction:
Are placental morphologic features and chorionic surface vasculature at term highly correlated with 3-dimensional sonographic measurements at 11 to 14 weeks?
### Response:
| Many important ultimate placental morphologic features are likely predetermined early in pregnancy. Three-dimensional sonography may play an increasing role in the in utero evaluation of the early placenta. |
### Instruction:
Does low-dose mifepristone increase uterine natural killer cell cytotoxicity and perforin expression during the receptive phase?
### Response:
| Mifepristone may negatively regulate implantation by increasing the cytotoxicity of uNK cells, and this increased cytotoxicity may result from increased PFN expression. These findings provide further evidence to support the potential contraceptive activity of low-dose mifepristone. |
### Instruction:
Does topical dexamethasone-cyclodextrin microparticle eye drop for diabetic macular edema?
### Response:
| Based on this short pilot study, topical dexamethasone-cyclodextrin eye drops are well tolerated, decrease central macular thickness, and improve visual acuity in DME. The results encourage comparative studies between dexamethasone cyclodextrin microparticle eye drops and other treatments for DME. (http://www.umin.ac.jp/ctr number, UMIN000001790.). |
### Instruction:
Is the clinical phenotype of trachomatous trichiasis in Ethiopia : not all trichiasis due to entropion?
### Response:
| Many patients with TT have minimal or no entropion. The trichiasis is frequently attributable to metaplastic or misdirected eyelashes. The results of tarsal rotation surgery in TT patients without manifest entropion should be investigated and potentially alternative treatment strategies evaluated. |
### Instruction:
Do levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis?
### Response:
| MMP-3 levels are a good marker for disease activity in JIA-ERA. |
### Instruction:
Is carotid endarterectomy within seven days after the neurological index event safe and effective in stroke prevention?
### Response:
| An infarction on the preoperative CCT leads to an increased risk for a postoperative deterioration after CEA. Patients should be treated at an early point in time with bland CCTs. |
### Instruction:
Is aspirin first-line treatment for migraine and episodic tension-type headache regardless of headache intensity?
### Response:
| In neither migraine nor ETTH does pre-treatment headache intensity predict success or failure of aspirin. This is not an arguable basis for stratified care in migraine. In both disorders, aspirin is first-line treatment regardless of headache intensity. |
### Instruction:
Does the association between anomalous self-experience and suicidality in first-episode schizophrenia seem mediated by depression?
### Response:
| The interaction between anomalous self-experiences and depression could be a rational clinical target for the prevention of suicidality in the early phases of schizophrenia and supports the rationale for including assessment of SDs in early intervention efforts. |
### Instruction:
Does prevalence and correlate of physiological valvular regurgitation in healthy subjects?
### Response:
| In healthy subjects, AR, MR or TR are commonly detected by using a current echo machine. These "physiological" valvular regurgitations should not be considered as a "pathological" valvular heart disease. |
### Instruction:
Does t-cell compartment in synovial fluid of pediatric patients with JIA correlate with disease phenotype?
### Response:
| In pediatric JIA patients, we showed an alteration in the T cells from synovial fluid, which correlated with disease phenotype, assumedly secondary to enhanced proliferation, clonal TCR restriction, and reduced T-cell production, possibly reflecting a different disease or a different course of disease progression. |
### Instruction:
Does persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affect liver fibrosis and differentiation?
### Response:
| HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation; they could be investigated as disease markers and potential therapeutic targets. |
### Instruction:
Are comparison of eight diagnostic algorithms for liver fibrosis in hepatitis C : new algorithms more precise and entirely noninvasive?
### Response:
| SAFE and BA for significant fibrosis or cirrhosis are very accurate. However, their successive use induces a significant decrease in diagnostic accuracy and a significant increase in required liver biopsy. A new fibrosis classification that synchronously combines two fibrosis tests was as accurate as successive SAFE or BA, while providing an entirely noninvasive (0% liver biopsy) and more precise (six versus two or three fibrosis classes) fibrosis diagnosis. |
### Instruction:
Is accuracy of self-reported family history strongly influenced by the accuracy of self-reported personal health status of relatives?
### Response:
| The accuracy of self-reported family history of diabetes and hypertension is strongly influenced by the accuracy of self-reported personal health status of relatives. Raising awareness of personal health status is crucial to ensure the utility of family history for the assessment of risk and disease prevention. |
### Instruction:
Does fAK regulate intestinal epithelial cell survival and proliferation during mucosal wound healing?
### Response:
| In the colon, FAK functions as a regulator of epithelial cell survival and proliferation under conditions of mucosal injury and a mechanosensor of tissue compliance, inducing repair-driven proliferation in the colonic epithelium through upregulation of cyclin D1. |
### Instruction:
Does sublingual tissue perfusion improve during emergency treatment of acute decompensated heart failure?
### Response:
| Sublingual tissue perfusion is diminished in ADHF but increases with treatment. It may represent a quantitative way to evaluate ADHF in the ED setting. |
### Instruction:
Do sevoflurane and desflurane protect cholinergic-induced bronchoconstriction of hyperreactive airways in rabbits?
### Response:
| If the contractile stimulus is cholinergic in origin, sevoflurane and desflurane exert similar bronchoprotective potentials to act against lung constriction independent of the presence of BHR. These volatile anesthetics otherwise lack a potential to improve the enhanced ventilation heterogeneities that develop particularly in the presence of BHR. |
### Instruction:
Does detection of asymptomatic adenocarcinoma at endoscopy prior to gastric banding justify routine endoscopy?
### Response:
| The detection of two early, asymptomatic oesophageal adenocarcinomas in a high risk patient group justifies our policy of routine upper GI endoscopy prior to gastric banding surgery. |
### Instruction:
Does a novel reporter of notch signalling indicate regulated and random Notch activation during vertebrate neurogenesis?
### Response:
| A novel Notch reporter with multiple destabilisation elements provides a faithful read-out of endogenous Notch activity on a cell-by-cell basis, as neural progenitors progress through the cell cycle in the chick neural tube. Notch activity patterns in this cell population provide evidence for distinct Notch signalling dynamics underlying different cell division modes and for the involvement of random initiation of Notch signalling within the neuroepithelium. These findings highlight the importance of single-cell analysis in the study of the complexity of Notch activity and provide new insights into the mechanisms underlying cell fate decisions in neural progenitors. |
### Instruction:
Do an update on influenza vaccination in patients with egg allergy?
### Response:
| In considering vaccination in a patient with a history of egg allergy, several factors should be weighed, including the severity of the egg allergy, the egg content of vaccines, and the setting of vaccine administration. However, it appears that the risk of anaphylaxis to the influenza vaccine in patients with egg allergy may be much lower than previously thought, suggesting that in many cases skin testing may not be necessary. |
### Instruction:
Does injection of human mesenchymal stem cells improve healing of vocal folds after scar excision -- a xenograft analysis?
### Response:
| Human mesenchymal stem cells injected into the rabbit VF following the excision of a chronic scar, were found to enhance the functional healing of the VF with reduced lamina propria thickness and restored viscoelastic shear properties. |
### Instruction:
Does survey disability questionnaire generate valid accurate data compared to clinical assessment on an older population?
### Response:
| A survey questionnaire is not a valid method for accurately estimating disability in a population. |
### Instruction:
Is the shortest way to reach nutritional goals to adopt Mediterranean food choices : evidence from computer-generated personalized diets?
### Response:
| Whether recommendations on total fats, MUFAs, or total carbohydrates are included or not in the definition of overall nutrient adequacy, foods typical of the Mediterranean diet are needed to reach overall nutrient adequacy. |
### Instruction:
Does one-year choroidal thickness result after photodynamic therapy for central serous chorioretinopathy?
### Response:
| Half-dose photodynamic therapy for central serous chorioretinopathy resulted in thinner subfoveal choroidal thickness 1 month after treatment, decreased the choroidal vascular hyperpermeability, and maintained the remission for 1 year. Enhanced depth imaging optical coherence tomography was helpful for monitoring the pathophysiologic choroidal changes in central serous chorioretinopathy. |
### Instruction:
Are plasma concentrations of efavirenz associated with body weight in HIV-positive individuals?
### Response:
| In this cohort of well-controlled HIV-positive individuals, patients with lower weight or body mass index had a higher chance of presenting elevated plasma concentrations of efavirenz. Therapeutic drug monitoring to adjust dose might be a helpful tool to decrease efavirenz dose in order to minimize costs and adverse effects. |
### Instruction:
Do plasma calprotectin levels reflect disease severity in patients with chronic heart failure?
### Response:
| Plasma calprotectin is increased in CHF patients, indicating that inflammatory activity is upregulated in CHF and may be associated with the severity of CHF. |
### Instruction:
Does extraction of maxillary first molars improve second and third molar inclinations in Class II Division 1 malocclusion?
### Response:
| Extraction of the maxillary first molars in Class II Division 1 patients results in significant uprighting of M2 and M3 and facilitates the normal eruption of M3. |
### Instruction:
Does pioglitazone prevent intimal hyperplasia in experimental rabbit vein grafts?
### Response:
| Pioglitazone attenuates intimal hyperplasia of the vein graft after autologous bypass grafting by its ability to suppress cell proliferation and enhance apoptosis. Pioglitazone could represent a therapeutic target for the prevention of graft failure after bypass grafting. |
### Instruction:
Does microRNA-758 regulate cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1?
### Response:
| We identified miR-758 as a novel miRNA that posttranscriptionally controls ABCA1 levels in different cells and regulates macrophage cellular cholesterol efflux to apoA1, opening new avenues to increase apoA1 and raise high-density lipoprotein levels. |
### Instruction:
Does angiopoietin-1 require IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense?
### Response:
| These experiments are the first demonstration of IQGAP1 regulating barrier function in any cell type. Further, our data show that Angpt-1 requires IQGAP1 as an indispensable activator of Rac1. |
### Instruction:
Does enchanced levels of apolipoprotein M during HBV infection feedback suppress HBV replication?
### Response:
| Raised ApoM levels in HBV infection may in turn suppress HBV replication, one of the protective mechanisms of nature. |
### Instruction:
Does the angiogenic factor Del1 prevent apoptosis of endothelial cells through integrin binding?
### Response:
| Del1 has been previously shown to promote vascular smooth muscle cell adhesion, migration, and proliferation. We demonstrate here that Del1 prevented apoptosis of endothelial cells in cell culture through integrin binding without any effect on proliferation. |
### Instruction:
Do homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma?
### Response:
| Polymorphic analysis may be a predictive tool to identify those at high risk of LON. Prospective studies are required to establish definitively if LON or FCGR3A-158V/V genotype influences outcome. |
### Instruction:
Do anatomy and physiology predict response to motor cortex stimulation after stroke?
### Response:
| In this clinical stroke trial, the more that the physiologic integrity of the motor system was preserved, the more likely that a patient was to derive gains from subsequent therapy, consistent with preclinical models. Functional and structural preservation of key brain substrates are important to deriving gain from a restorative therapy. |
### Instruction:
Is biventricular pacing superior to right ventricular pacing in bradycardia patients with preserved systolic function : 2-year results of the PACE trial?
### Response:
| Left ventricular adverse remodelling and deterioration of systolic function continues at the second year after RVA pacing. This deterioration is prevented by BiV pacing. |
### Instruction:
Is positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis widespread after status epilepticus?
### Response:
| Our results suggest that alterations of cation-chloride cotransporter functions, comprising a higher NKCC1 action, contribute to hyperexcitability within the hippocampus following SE. |
### Instruction:
Does esmolol modulate inhibitory neurotransmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat?
### Response:
| These data suggest that esmolol modulates inhibitory transmitter release in the Sp5c through a mechanism involving Ca2+-entry but in a β1-adrenoceptor-independent manner. The present results suggest that the facilitation of inhibitory transmitter release in the central nociceptive network underlies, at least in part, the antinociceptive effect of esmolol. |
### Instruction:
Are qRS duration and QTc interval predictors of risk for ventricular arrhythmias during cardiac resynchronization therapy?
### Response:
| A pacing-induced increase in QTc and QRSd is related to sVTA in patients with CRT. Further studies are needed to determine whether optimization of CRT with the goal to achieve a narrow paced QRSd can reduce the occurrence of sVTA. |
### Instruction:
Does deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice?
### Response:
| These results demonstrate that G6pc2 is an important driver for the selection and expansion of islet-reactive CD8(+) T cells infiltrating NOD/ShiLtJ islets. However, autoreactivity to G6pc2 is not essential for the emergence of autoimmune diabetes. The results remain consistent with previous studies indicating that insulin may be the primary autoimmune target, at least in NOD/ShiLtJ mice. |
### Instruction:
Do angiotensin II receptors modulate muscle microvascular and metabolic responses to insulin in vivo?
### Response:
| We conclude that both AT(1)Rs and AT(2)Rs regulate insulin's microvascular and metabolic action in muscle. Although AT(1)R activity restrains muscle metabolic responses to insulin via decreased microvascular recruitment and insulin delivery, AT(2)R activity is required for normal microvascular responses to insulin. Thus, pharmacologic manipulation aimed at increasing the AT(2)R-to-AT(1)R activity ratio may afford the potential to improve muscle insulin sensitivity and glucose metabolism. |
### Instruction:
Are expansion of Th17 cells and functional defects in T regulatory cells key features of the pancreatic lymph nodes in patients with type 1 diabetes?
### Response:
| These data provide evidence for an unbalanced immune status in the PLNs of type 1 diabetic subjects, and treatments restoring the immune homeostasis in the target organ of these patients represent a potential therapeutic strategy. |
### Instruction:
Do lipid peroxidation and parathyroid hormone influence the cytosolic calcium levels of erythrocytes in peritoneal dialysis patients?
### Response:
| Our results confirm that oxidative stress is an important risk factor for CAPD. The results of multiple regression analysis suggest that RBC calcium was affected by both increased levels of TBARS and PTH. |
### Instruction:
Does hypoglycemia impair quality of blood glucose simulation in a clinical decision support system?
### Response:
| The present data show that hypoglycemia introduces substantial and systematic simulation errors for up to 24 h after hypoglycemia. This underlines the need for further evaluation of mechanisms behind this putative long-term glucose counter-regulation to hypoglycemia. When using blood glucose simulations in decision support systems, the results indicate that simulations for several hours following a hypoglycemic event may underestimate glucose levels by 100 mg/dl (5.6 mmol/liter) or more. |
### Instruction:
Does high density lipoprotein ( HDL ) promote glucose uptake in adipocytes and glycogen synthesis in muscle cells?
### Response:
| HDL stimulates glucose uptake in 3T3-L1 adipocytes through enhancing GLUT4 translocation by mechanisms involving PI3K/Akt via SR-BI and AMPK signaling pathways, and increases glycogen deposition in L6 muscle cells through promoting GSK3 phosphorylation. |
### Instruction:
Is glucocorticoid receptor polymorphism associated with lithium response in bipolar patients?
### Response:
| The GR gene variation seems to be involved in the response to lithium treatment in our group of bipolar patients. |
### Instruction:
Are chemerin levels positively correlated with abdominal visceral fat accumulation?
### Response:
| Abdominal visceral fat accumulation, blood pressure and lipid profile were significantly associated with serum chemerin levels. Our findings suggest that chemerin may be a mediator that links visceral obesity to cardiovascular risk factors. |
### Instruction:
Does abnormal T2-weighted MRI signal surrounding lead in a subset of deep brain stimulation patients?
### Response:
| Fifteen instances of T2 signal hyperintensity surrounding DBS leads on postoperative MRI scans were observed across 239 implants (6.3% incidence) in 133 patients. The signal characteristics were most consistent with vasogenic edema, possibly representing an inflammatory response. The finding was typically unilateral, even in patients with simultaneous bilateral lead implants. Most affected patients were asymptomatic, although 3 were symptomatic and 1 experienced marked gait instability that was treated with steroids. T2 signal abnormality was seen more commonly in scans obtained 3 or more days after surgery than in those collected immediately postoperatively. No differences in age, anatomical target, diagnosis, or number of microelectrode passes were noted between patients with or without T2 signal. Further research will be needed to explain this curious neuroimaging finding, and to rule out cause for clinical concern. |
### Instruction:
Is liver stiffness measured by transient elastography a predictor of hepatocellular carcinoma development in viral hepatitis?
### Response:
| Liver stiffness as measured by transient elastography is a predictor of HCC development in viral hepatitis. |
### Instruction:
Does acute inhalation of hypertonic saline improve mucociliary clearance in all children with cystic fibrosis?
### Response:
| These data suggest that percent MCC varies significantly between children with CF lung disease and normal pulmonary functions, with some children demonstrating MCC values within the normal range and others showing MCC values that are below normal values. In addition, although MCC did not improve in all children after inhalation of HS, improvement did occur in children with relatively low MCC values after placebo. This finding suggests that acute inhalation of hypertonic saline may benefit a subset of children with low MCC values. |
### Instruction:
Does methyl-binding domain protein-based DNA isolation from human blood serum combine DNA analyses and serum-autoantibody testing?
### Response:
| MBD affinity purification allows DNA isolations under native conditions retaining the protein function, thus for example enabling combined analyses of DNA methylation and autoantigene-profiles from the same serum sample and thereby improving minimal invasive diagnostics. |
### Instruction:
Does a unique protein profile of peripheral neutrophils from COPD patients reflect cytokine-induced protein profiles of neutrophils in vitro?
### Response:
| These results show that neutrophils from COPD patients have a unique protein profile compared to neutrophils from healthy age-matched controls. Furthermore, the neutrophil profiles of COPD patients do not reflect putative dominant signals induced by TNFα, GM-CSF or their combination. Our results indicate that systemic neutrophil responses in COPD patients are caused by a unique but subtle interplay between multiple inflammatory signals. |
### Instruction:
Do perspectives on child diarrhoea management and health service use among ethnic minority caregivers in Vietnam?
### Response:
| In order to improve EMGs' use of government health services it is necessary to improve the communication skills of health staff and to acknowledge both EMGs' explanatory disease models and the significant socio-economic constraints they experience. Broader health promotion programs should address the significant gender roles preventing highland mothers from seeking health services and include family elders and fathers in future health promotion programs. Encouraging existing child health care practices, including continued breastfeeding during illness and the use of home-made rehydration solutions, also present important opportunities for future child health promotion. |
### Instruction:
Is cyclin-dependent kinase inhibitor p21 , via its C-terminal domain , essential for resolution of murine inflammatory arthritis?
### Response:
| These are the first reported data to reveal that p21 has a key role in limiting the activation response of macrophages in an inflammatory disease such as RA. Thus, targeting p21 in macrophages may be crucial for suppressing the development and persistence of RA. |
### Instruction:
Is metabolic syndrome associated with increased risk of recurrent colorectal adenomas in Korean men?
### Response:
| Metabolic syndrome and obesity were significantly associated with the development of recurrent colorectal adenomas in Korean adult males. Furthermore, these associations were more strongly associated with advanced adenomas. |
### Instruction:
Is there no association of CCR6 polymorphisms with susceptibility to Behcet 's disease in two Chinese Han populations?
### Response:
| The tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations. |
### Instruction:
Does c5a contribute to intraocular inflammation by affecting retinal pigment epithelial cells and immune cells?
### Response:
| The results provide a direct link between complement activation and intraocular inflammation. This line of information may help to understand the mechanism of the pathogenesis of intraocular inflammatory diseases. Moreover, the authors show that a close, reciprocal interaction between the innate immune system and the adaptive immune system may be involved in the development of such diseases. |
### Instruction:
Does recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibit hepatocellular carcinoma xenograft growth in mice?
### Response:
| These results suggest that the potent inhibitive effect of HNF1α on HCC is attained by inducing the differentiation of hepatoma cells into mature hepatocytes and G(2)/M arrest. HNF1α might represent a novel, promising therapeutic agent for human HCC treatment. Our findings also encourage the evaluation of differentiation therapy for tumors of organs other than liver using their corresponding differentiation-determining transcription factor. |
### Instruction:
Does patterns and correlate of prescription opioid use in OEF/OIF veterans with chronic noncancer pain?
### Response:
| Prescription opioid use is common among OEF/OIF veterans with CNCP and is associated with several pain diagnoses and medical conditions. |
### Instruction:
Does topical aqueous suppression significantly affect duration of intraocular gas tamponade after vitrectomy?
### Response:
| Topical aqueous suppression with dorzolamide-timolol does not have a large effect on duration of SF6 gas tamponade after pars plana vitrectomy. |
### Instruction:
Is mindfulness associated with fewer PTSD symptoms , depressive symptoms , physical symptoms , and alcohol problems in urban firefighters?
### Response:
| Mindfulness may be important to consider and include in models of stress, coping, and resilience in firefighters. Future studies should examine the prospective relationship between mindfulness and health in firefighters and others in high-stress occupations. |
### Instruction:
Do multivariate graphical methods provide an insightful way to formulate explanatory hypotheses from limited categorical data?
### Response:
| Illustrative applications of a sequence of graphical procedures yield more informative and less abstract representations of limited data than do descriptive statistics alone, and by doing so, they aid in the formulation of explanatory hypotheses. |
### Instruction:
Is chlamydia pneumoniae heat shock protein 60 associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients?
### Response:
| Genes/proteins of pre-apoptotic caspase dependent/independent pathways, chemokines, and inflammatory cytokines receptors were significantly up-regulated in human atheromatous plaques of cHSP60 positive CAD patients suggesting an association of cHSP60 with CAD. |
### Instruction:
Do [ Inflammatory factors promote the development of colorectal cancer ]?
### Response:
| The serum level of inflammatory cytokines TGF-β 1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC. |
### Instruction:
Does medical journal cover -- an analysis of gendered images and how these might influence best practice?
### Response:
| While the images investigated are engaging and sometimes amusing, we explore meanings beyond our engagement as a viewer. The discussion focuses on the need for promotion of best practice, in words and pictures, to model best professional practice. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.