Datasets:
typosonlr
/
PubMedPreProcessed

Dataset card Data Studio Files
xet
Community
1
question
stringlengths
52
373
long_answer
stringlengths
1
3.34k
### Instruction: Does long non-coding RNA ANRIL promote the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway? ### Response:
ANRIL may reduce p15INK4B expression through inhibiting TGF-β/Smad signaling pathway, promoting invasion and metastasis of TC cells, and the silencing of ANRIL inhibits the invasion and metastasis of TPC-1 cells.
### Instruction: Does tollip SNP rs5743899 modulate human airway epithelial responses to rhinovirus infection? ### Response:
Our data suggest that Tollip SNP rs5743899 may predict varying airway response to RV infection in asthma.
### Instruction: Do logic models help make sense of complexity in systematic reviews and health technology assessments? ### Response:
Logic models can help authors of systematic reviews and HTAs to explicitly address and make sense of complexity, adding value by achieving a better understanding of the interactions between the intervention, its implementation, and its multiple outcomes among a given population and context. They thus have the potential to help build systematic review capacity-in SSA and other LMICs-at an individual level, by equipping authors with a tool that facilitates the review process; and at a system-level, by improving communication between producers and potential users of research evidence.
### Instruction: Do infant and young child feeding practices differ by ethnicity of Vietnamese mothers? ### Response:
Breastfeeding practices were suboptimal and differed by ethnicity, which suggests need for tailored interventions at multiple levels to address ethnic-specific challenges and norms. Complementary feeding practices were less optimal among ethnic minorities compared to Kinh, which suggests need for broad intervention including improved food availability, accessibility, and security.
### Instruction: Does two Hours of Teamwork Training improve Teamwork in Simulated Cardiopulmonary Arrest Events? ### Response:
A 2-hour simulation-based teamwork educational intervention resulted in improved perceptions of teamwork behaviors. Participants reported interactions with other disciplines, teamwork behavior education, and debriefing sessions were beneficial for enhancing the program.
### Instruction: Are specific patterns of laryngeal electromyography during wakefulness associated to sleep disordered breathing and nocturnal stridor in multiple system atrophy? ### Response:
Electromyographic/kinesiologic investigation of VC muscles during wakefulness provides additional information on the pathophysiology of the respiratory abnormalities in MSA patients that could be useful for guiding the choice of the best appropriate treatment and care.
### Instruction: Does local brain activity persist during apparently generalized postictal EEG suppression? ### Response:
Our results reveal that, during apparently generalized postictal EEG suppression, local brain activity persists or reemerges in most GCS. Possible implications of this localized neuronal activity in the context of SUDEP are discussed in the paper.
### Instruction: Does interictal epileptic discharge correlate with global and frontal cognitive dysfunction in temporal lobe epilepsy? ### Response:
In patients with TLE of long duration, IED occurrence was strongly related to cognitive deficits, most pronounced for frontal lobe function. These data suggest that IEDs reflect dysfunctional brain circuitry and may serve as an independent biomarker for cognitive comorbidity.
### Instruction: Is intensity-Modulated Radiation Therapy Associated with Perioperative or Survival Benefit over 3D-Conformal Radiotherapy for Rectal Cancer? ### Response:
IMRT is associated with worse local tumor control without any long-term survival benefit for patients with locally advanced rectal cancer. Given the lack of significant advantage and the higher cost of IMRT, caution should be exercised when using IMRT instead of traditional 3D-CRT for rectal cancer.
### Instruction: Do statin drugs decrease progression to cirrhosis in HIV/HCV co-infected individuals? ### Response:
Statin drug use is beneficial in mitigating the risk of liver disease progression for HIV/HCV co-infected patients without advanced liver disease. Low-HDL and diabetes in co-infected patients with abnormal ALT have greater risk of cirrhosis development.
### Instruction: Does students ' Interest in Surgery affect Laparoscopic Practicing Performance? ### Response:
Those clerks and interns interested in surgery who had more sessions for self-guided practice, displayed more improvement than those not interested in surgery did. Improvement in performance correlated highly with trainees' number of self-guided practice sessions.
### Instruction: Does wnt/Beta-Catenin Signal Inhibitor HC-1 sensitize Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population? ### Response:
These data suggest that HC-1 is an effective compound to target cancer stem cells, and the combination treatment of HC-1 and 5-fluorouracil can stimulate the tumor suppressive effect on oral squamous cell carcinoma cells.
### Instruction: Does transcriptome analysis in oak uncover a strong impact of endogenous rhythmic growth on the interaction with plant-parasitic nematodes? ### Response:
The results highlight that gene response patterns of plants to biotic interactions, both negative (i.e. plant-parasitic nematodes) and beneficial (i.e. mycorrhiza), are largely modulated by endogenous rhythmic growth, and that such plant traits should be considered as an important driver of these relationships in future studies.
### Instruction: Is reactive hyperemia associated with adverse clinical outcomes in heart failure? ### Response:
The association of reduced hyperemic flow with increased risk of adverse clinical outcomes suggests that micro-vascular function may be an important prognostic marker in patients with HF.
### Instruction: Is renal assessment using CKD-EPI equation useful as an early predictor of contrast- induced nephropathy in elderly patients with cancer? ### Response:
In elderly patients with cancer who visit the emergency department, renal assessment before CECT using CKD-EPI equation was superior to SCr alone, MDRD equation, or CG formula in predicting the occurrence of CIN related CECT.
### Instruction: Is combined Use of Bivalirudin and Radial Access in Acute Coronary Syndromes Superior to the Use of Either One Separately : Meta-Analysis of Randomized Controlled Trials? ### Response:
Bivalirudin reduces bleeding risk only with femoral access, and radial access reduces bleeding risk only with heparin anticoagulation. Therefore, there is no additional benefit to the combined use of bivalirudin and radial access strategies in patients with ACS.
### Instruction: Do cancer Patients Are at High Risk of Mortality if Presenting with Sepsis at an Emergency Department? ### Response:
Cancer patients have double the risk of mortality if presenting with sepsis at the ED.
### Instruction: Does gT-repeat length polymorphism in heme oxygenase-1 promoter determine the effect of cilostazol on vascular smooth muscle cells? ### Response:
Cilostazol inhibits VSMC proliferation involving an association between CREB and HO-1. The length polymorphism of GT-repeat in human HO-1 promoter determines the effect of cilostazol.
### Instruction: Does mindfulness-based Intervention Influence Cardiac Autonomic Control or Pattern of Physical Activity in Fibromyalgia During Daily Life : An Ambulatory , Multi-measure Randomized Controlled Trial? ### Response:
MBSR did not produce cardiac autonomic benefits or changes in daily activity in fibromyalgia. Furthermore, lack of association between patient-experienced clinical improvement and objective autonomic measures suggests subjective changes in wellbeing among fibromyalgia patients over time are not related to alterations in cardiorespiratory autonomic function or activity levels.
### Instruction: Is leukocyte-poor platelet-rich plasma more effective than the conventional therapy with acetaminophen for the treatment of early knee osteoarthritis? ### Response:
Treatment with LP-PRP injections resulted in a significantly better clinical outcome than did treatment with acetaminophen, with sustained lower EVA and WOMAC scores and improvement in quality-of-life (higher SF-12 score). Therapy with LP-PRP may positively modify the inflammatory joint environment by counteracting IL-1β action.
### Instruction: Is gene and Protein Expression of Chemokine ( C-C-Motif ) Ligand 19 Upregulated in Unstable Carotid Atherosclerotic Plaques? ### Response:
CCL19 is significantly overexpressed in patients with unstable carotid atherosclerotic plaques and may be a possible novel biomarker for identifying high-risk patients in whom more urgent intervention may be indicated.
### Instruction: Do socioeconomic Risk Adjustment Models for Reimbursement Are Necessary in Primary Total Joint Arthroplasty? ### Response:
Patients in the lowest SES group utilize more resources in the 90-day postoperative period. Therefore, risk adjustment models, including SES, may be necessary to fairly compensate hospitals and surgeons and to avoid potential problems with access to joint arthroplasty care.
### Instruction: Does antibiotic-Induced Gut Microbiota Disruption decrease TNF-α Release by Mononuclear Cells in Healthy Adults? ### Response:
In this proof-of-principle study of healthy subjects, microbiota disruption by broad-spectrum antibiotics is reversibly associated with decreased systemic cellular responsiveness towards LPS. The implications of these findings in a clinical setting remain to be determined.
### Instruction: Does the downregulation of ANGPTL4 inhibit the migration and proliferation of tongue squamous cell carcinoma? ### Response:
High expression levels of ANGPTL4 are associated with the T stage, lymphatic metastasis, angiogenesis and poor overall survival in TSCC patients. The downregulation of ANGPTL4 inhibits the migration and proliferation of cells in TSCC. Taken together, ANGPTL4 may serve as a novel biomarker and therapeutic target for TSCC.
### Instruction: Does melatonin Receptor 1-Deficiency affect Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice? ### Response:
Thus, the MT1-mediated signaling stimulates Pomc expression in a region-specific pattern. Since the MT1 mediated changes in Pomc expression do not elicit direct orexigenic or anorexigenic effects such effects are obviously mediated by regulatory systems downstream of the POMC mRNA (e.g. cleavage and release of pro-opiomelanocortin derivatives) which are independent of MT1 signaling.
### Instruction: Do eNPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical treatment response in dentofacial deformities? ### Response:
This study allows us to identify sub-populations at high risk of developing postoperative temporomandibular disorders after orthognathic surgery procedures. Many other genes of interest could be potential factors influencing the dysfunctional response to orthognathic surgery, particularly genes of the Opera cohort.
### Instruction: Are red deer bone and antler collagen isotopically equivalent in carbon and nitrogen? ### Response:
Bone and antler collagen δ(13) C and δ(15) N values are not isotopically equivalent and are therefore not directly comparable in palaeodietary, palaeoclimate and palaeocological studies. Bone and antler collagen isotopic differences probably relate to differential metabolic processes during the formation of the two tissues. Intra- and inter-antler isotopic variations probably reflect the isotopic composition of an individual's diet rather than physiological parameters, and may have the potential to provide high-resolution individual-specific information in modern and ancient cervid populations. Copyright © 2016 John Wiley & Sons, Ltd.
### Instruction: Is excessive bleeding a normal cleansing process : a qualitative study of postpartum haemorrhage among rural Uganda women? ### Response:
The community viewed bleeding after childbirth as a normal process and their methods of determining excessive bleeding are imprecise and varied. This opens the door for intervention for reducing delays in the home diagnosis of PPH. This includes increasing awareness among TBAs, women and their families about the risk of death due to excessive bleeding in the immediate postpartum period.
### Instruction: Is the link between metabolic features and TSH levels in polycystic ovary syndrome modulated by the body weight : an euglycaemic-hyperinsulinaemic clamp study? ### Response:
Our data confirm that the prevalence of SCH is increased in PCOS women. The presence of SCH is associated with endocrine and metabolic imbalances of PCOS, and the excessive body weight seems to promote this interplay.
### Instruction: Does lRG1 mRNA expression in breast cancer associate with PIK3CA genotype and with aromatase inhibitor therapy outcome? ### Response:
We showed in two datasets of ER positive and luminal breast tumors that the expression of 3 miRs and 9 mRNAs associate with the PIK3CA status. Expression of LRG1 is independent of luminal (A or B) subtype, decreased after neo-adjuvant AI-treatment, and is proposed as potential biomarker for AI therapy outcome.
### Instruction: Is indocyanine green retention a potential prognostic indicator after splenectomy and pericardial devascularization for cirrhotic patients? ### Response:
ICGR15 has outperformed the Child-Pugh classification for assessing liver function in cirrhotic patients with portal hypertension. ICGR15 may be a suitable prognostic indicator for cirrhotic patients after SPD.
### Instruction: Does release of Cathepsin B in Cytosol cause Cell Death in Acute Pancreatitis? ### Response:
This report defines the role of trypsin in AP and shows that cytosolic cathepsin B but not trypsin activates cell death pathways. This report also suggests that trypsin is a requisite for AP only because it causes release of cathepsin B into the cytosol.
### Instruction: Does aortic prosthesis-patient mismatch strongly affect early results of double valve replacement? ### Response:
Aortic PPM greatly affects the postoperative outcome of DVR, as it is related to an increased complication rate and a higher in-hospital mortality. A strategy of avoiding PPM but without taking additional risks might improve the early results of DVR.
### Instruction: Is nuclear expression of phosphorylated focal adhesion kinase associated with poor prognosis in human colorectal cancer? ### Response:
P-FAK expression is an independent prognostic marker in CRC. The present data suggest that the FAK signalling pathway may interact with TNS4, a known oncogene in CRC.
### Instruction: Does chronic kidney disease predict long-term mortality after major lower extremity amputation? ### Response:
Metabolic syndrome is not associated with increased risk of adverse outcomes after lower extremity amputation. However, patients with chronic kidney disease constitute a sub-group of patients at higher risk of postoperative long-term mortality and may be a group to target for intervention.
### Instruction: Is eD bedside point-of-care lactate in patients with suspected sepsis associated with reduced time to iv fluids and mortality? ### Response:
Implementation of bedside POC lactate measurement in adult ED patients with suspected sepsis reduces time to test results and time to administration of IV fluids but not antibiotics. A significant reduction in mortality and ICU admissions was also demonstrated, which is likely due, at least in part, to POC testing.
### Instruction: Is sIRT1 required for oncogenic transformation of neural stem cells and for the survival of `` cancer cells with neural stemness '' in a p53-dependent manner? ### Response:
These results indicate that expression of SIRT1 in cancer cells with neural stemness plays an important role in suppressing p53-dependent tumor surveillance, the abrogation of which may be responsible not only for inducing oncogenic transformation but also for retaining the neural cancer stemness of the cells, suggesting that SIRT1 may be a putative therapeutic target in GSCs.
### Instruction: Is acinetobacter baumannii infection in prior ICU bed occupants an independent risk factor for subsequent cases of ventilator-associated pneumonia? ### Response:
ICU admission or the hospitalization of patients infected by Acinetobacter baumannii increases the risk of AbVAP by subsequent patients.
### Instruction: Is apoptosis inhibitor-5 overexpression associated with tumor progression and poor prognosis in patients with cervical cancer? ### Response:
API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival, supporting that API5 may be a promising novel target for therapeutic interventions.
### Instruction: Does preservation of the rectus femoris origin during periacetabular osteotomy compromise acetabular reorientation? ### Response:
The approach modification was straightforward to implement in all patients and did not compromise acetabular fragment mobilization or final positioning. Two of the three key variables that the approach might have influenced-pain and length of stay-were below the minimum clinically important difference and different by only a fraction of a day, respectively. The difference in ambulation was of only modest clinical importance. More definitive evidence for clinical superiority in terms of pain, ambulation, and return of muscle function will likely require more sophisticated instruments such as gait analysis, muscle strength testing, and longer-term outcome studies with sensitive instruments.
### Instruction: Does above 5 cm , size matter anymore in patients with hepatocellular carcinoma? ### Response:
Although recurrence rates are high, surgical resection for solitary HCC offers good overall survival. Tumor size was not a prognostic factor. Solitary large HCC >10 cm would be a good candidate for hepatectomy as well as solitary HCC between 5 and 10 cm.
### Instruction: Do both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner? ### Response:
As VP4 of genotype P[8] is a component of current RV vaccines, our finding that Lewis-negative children are resistant to P[8] strains provides a plausible explanation for the reduced vaccine efficacy in populations with a high percentage of Lewis-negative individuals, such as in Africa. Furthermore, our findings provide a plausible explanation as to why P[6] RV strains are more common in Africa.
### Instruction: Does a farnesoid X receptor polymorphism predispose to spontaneous bacterial peritonitis? ### Response:
The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.
### Instruction: Does adaptive brain shut-down counteract neuroinflammation in the near-term ovine fetus? ### Response:
Adaptive brain shut-down during labor-like worsening acidemia counteracts neuroinflammation in a hypoxia- and time-dependent manner.
### Instruction: Is cross-section perimeter a suitable parameter to describe the effects of different baffle geometries in shaken microtiter plates? ### Response:
Calculated and experimentally determined OTRmax values agree within ± 30% accuracy. Furthermore, undesired out-of-phase operating conditions can be identified by using the relative perimeter as key parameter. Finally, an optimum well geometry characterized by an increased perimeter of 10% compared to the unbaffled round geometry is identified. This study may also assist to comprehensively describe and optimize the baffles of shake flasks in future.
### Instruction: Does the effect of neighbourhood unemployment on health-risk behaviours in elderly differ between Slovak and Dutch cities? ### Response:
Countries differed in the associations with HRB of both neighbourhood unemployment and individual SEP among the elderly urban residents. The local importance of socio-economic factors on both levels should be considered when developing health-promotion activities for the elderly.
### Instruction: Does sildenafil enhance the peripheral antinociceptive effect of ellagic acid in the rat formalin test? ### Response:
Our results suggest that EA has local peripheral antinociceptive activity, and enhancement of this effect with sildenafil probably occurs through the inhibition of cGMP metabolism.
### Instruction: Does topical vitamin K1 promote repair of full thickness wound in rat? ### Response:
Topical vitamin K demonstrates wound healing potential in full-thickness wound model.
### Instruction: Is fatty acid binding protein-4 expressed in the mouse placental labyrinth , yet is dispensable for placental triglyceride accumulation and fetal growth? ### Response:
FABP4 is expressed in the mouse placental labyrinth, with highest expression at E16.5. FABP4 is dispensable for feto-placental growth and placental lipid accumulation.
### Instruction: Is low birth weight associated with adiposity , impaired skeletal muscle energetics and weight loss resistance in mice? ### Response:
Our results reveal that in utero undernutrition alters metabolic physiology through a profound effect on skeletal muscle energetics and blunts response to a hypocaloric diet in adulthood. We propose that mitochondrial dysfunction links undernutrition in utero with metabolic disease in adulthood.
### Instruction: Is early repolarization associated with atrial and ventricular tachyarrhythmias in patients with acute ST elevation myocardial infarction undergoing primary percutaneous coronary intervention? ### Response:
The ER pattern is commonly observed in patients with STEMI and associated with atrial and ventricular tachyarrhythmia during acute setting.
### Instruction: Does estradiol bound to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro? ### Response:
Estradiol concentrations in hyperestrogenemic syndromes may interfere with INS binding to its receptor producing significant INS resistance.
### Instruction: Do plasma protein biomarkers enhance the clinical prediction of kidney injury recovery in patients undergoing liver transplantation? ### Response:
These data suggest that plasma protein profiles might improve the prediction of pre-LT kidney injury recovery after LT. However, multicenter, prospective studies are needed to validate these findings and ultimately test the value of such protein panels in perioperative management and decision making.
### Instruction: Does neighborhood influence on recreational physical activity and survival after breast cancer? ### Response:
Certain aspects of the neighborhood have independent associations with recreational physical activity among breast cancer patients and their survival. Considering neighborhood factors may aide in the design of more effective, tailored physical activity programs for breast cancer survivors.
### Instruction: Is basal and β-adrenergic cardiomyocytes contractility dysfunction induced by dietary protein restriction associated with downregulation of SERCA2a expression and disturbance of endoplasmic reticulum Ca2+ regulation in rats? ### Response:
The observations reveal that protein restriction induces marked myocardial morphofunctional damage. The pathological changes of cardiomyocyte mechanics suggest the potential involvement of the β-adrenergic system, which is possibly associated with changes in SERCA2a expression and disturbances in Ca(2+) intracellular kinetics.
### Instruction: Does autocrine secretion of 15d-PGJ2 mediate simvastatin-induced apoptotic burst in human metastatic melanoma cells? ### Response:
We characterized simvastatin-induced activation of the 15d-PGJ2 /FABP5 signalling cascades, which triggered an apoptotic burst in melanoma cells but did not affect primary human melanocytes. These data support the rationale for the pharmacological targeting of 15d-PGJ2 in metastatic melanoma.
### Instruction: Is t-cell receptor diversity selectively skewed in T-cell populations of patients with Wiskott-Aldrich syndrome? ### Response:
Our results indicate that WAS gene mutations selectively influence TCR repertoire development or expansion in CD45RO(+) (memory) CD4(+) T cells.
### Instruction: Does greater body mass independently predict less radiographic progression on X-ray and MRI over 1-2 years? ### Response:
Greater BMI is associated with a lower risk of progression on X-ray and MRI over 2 years. Subjects with greater BMI also demonstrate less bone oedema at baseline. Greater BMI may indicate a less aggressive RA phenotype and aid in risk stratification.
### Instruction: Does comparison of gene expression microarray data with count-based RNA measurements inform microarray interpretation? ### Response:
Microarray measurements generally correlate with relative RNA molecule counts within optimal ranges but suffer from expression-dependent accuracy bias and precision that varies across datasets. We urge microarray users to consider expression-level effects in signal interpretation and to evaluate noise properties in each dataset independently.
### Instruction: Is a novel BHLHE41 variant associated with short sleep and resistance to sleep deprivation in humans? ### Response:
There are a number of mutations of BHLHE41. Mutations reduce total sleep while maintaining NREM sleep and provide resistance to the effects of sleep loss. Mutations that affect sleep also modify the normal inhibition of BHLHE41 of CLOCK/BMAL1 transactivation. Thus, clock mechanisms are likely involved in setting sleep length and the magnitude of sleep homeostasis.
### Instruction: Is subcortical atrophy associated with cognitive impairment in mild Parkinson disease : a combined investigation of volumetric changes , cortical thickness , and vertex-based shape analysis? ### Response:
Patients with Parkinson disease with mild cognitive impairment demonstrated reduced subcortical volumes, which were associated with cognitive deficits. The thalamus, nucleus accumbens, and putamen may serve as potential biomarkers for Parkinson disease-mild cognitive impairment.
### Instruction: Is gOLP3 a predictor of survival in patients with hepatocellular carcinoma? ### Response:
GOLPH3 was overexpressed in HCC at both the mRNA and protein levels, and the presence of high levels of expression of GOLPH3 could serve as a novel and potential prognostic biomarker for liver cancer patients.
### Instruction: Do lymph node metastases impact survival in follicular variant papillary thyroid cancer? ### Response:
LNM occur in less than 10% of patients with FVPTC but do not impact DSM. Instead, DSM in FVPTC is related to size and local invasion.
### Instruction: Do histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells? ### Response:
Histones induce RBCs to express a procoagulant phenotype through the externalization of PS. This finding provides new insights into the prothrombotic activity of extracellular histones.
### Instruction: Does aMP-activated protein kinase deficiency rescue paraquat-induced cardiac contractile dysfunction through an autophagy-dependent mechanism? ### Response:
Taken together, our findings revealed that AMPK may mediate paraquat-induced myocardial anomalies possibly by regulating the AMPK/mTOR-dependent autophagy.
### Instruction: Is depigmentation caused by application of the active brightening material , rhododendrol , related to tyrosinase activity at a certain threshold? ### Response:
The generation of a tyrosinase-catalyzed hydroxyl-metabolite is one of the causes for the diminishment of the melanocyte viability by rhododendrol.
### Instruction: Is adherence to exercise programs for older people influenced by program characteristics and personal factors : a systematic review? ### Response:
Older people's adherence to exercise programs is most commonly measured with dropout and attendance rates and is associated with a range of program and personal factors.
### Instruction: Does comparative characterization of GmSPX members reveal that GmSPX3 is involved in phosphate homeostasis in soybean? ### Response:
Taken together, the results suggest that GmSPX3 is a positive regulator in the P signalling network, and controls Pi homeostasis in soybean.
### Instruction: Does pancreatic intubation facilitated by methylene blue injection decrease the risk for postpapillectomy acute pancreatitis? ### Response:
Endoscopic papillectomy is safe and effective in the hands of experts. Pancreatic-duct stent placement in fewer cannulation attempts could be facilitated by injection of MB before papillectomy, and this decreases the risk for postprocedure pancreatitis. Recurrences can be managed endoscopically, but with a higher risk for pancreatitis.
### Instruction: Does short-hairpin RNA-mediated MTA2 silencing inhibit human breast cancer cell line MDA-MB231 proliferation and metastasis? ### Response:
For the first time to our knowledge we showed that MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer. The role of MTA2 in breast cancer growth and metastasis might be linked with regulation of matrix metalloproteinase and apoptosis.
### Instruction: Does high or low calcium intake increase cardiovascular disease risks in older patients with type 2 diabetes? ### Response:
High or low calcium intake increases cardiovascular disease risks. We suggest that "moderate" intake of 402-600 mg Ca/day (approximately 67%-100% of Taiwan RDA for Ca) and adequate Mg intake (or meeting RDA for Mg) with Ca:Mg intake ratio of 2.0-2.5 are important for reducing cardiovascular disease risks in older patients with diabetes.
### Instruction: Does long-term , low-dose lithium treatment impair renal function in the elderly : a 2-year randomized , placebo-controlled trial followed by single-blind extension? ### Response:
Chronic use of lithium at low doses did not affect renal function and was clinically safe. However, some other potentially relevant adverse events were observed and others could not be ruled out due to limitations of the study design.
### Instruction: Does comparative genomic hybridization show complex genomic changes of plasmacytoid urothelial carcinoma? ### Response:
In PUCs, the frequency of aneuploidy and the complexity of genomic changes per tumor are greater than those described in conventional UC. The aberrations described in PUC involve the same regions that are associated with aggressive biological behavior in conventional UC. Gains on 11q, 17q, 17p, and 20q and losses on 4q and 6q affect most PUCs and seem to harbor important chromosomal regions for PUC carcinogenesis. Large-scale deletions on chromosome 9 were not detected. CNV analysis indicates heterozygous deletion of CDH1 as one underlying mechanism of loss of membranous E-cadherin in PUC. Loss of CCND1 and SNAI1 is a common molecular feature and could contribute to the aggressive biological behavior of PUC.
### Instruction: Is impaired subjective well-being in schizophrenia associated with reduced anterior cingulate activity during reward processing? ### Response:
In patients with schizophrenia, reduced activation of the dACC during multiple aspects of reward processing is associated with lower SW. As the dACC has been widely linked to coupling of reward and action, and the link to SW is apparent over anticipation and outcome, these findings suggest that SW deficits in schizophrenia may be attributable to reduced integration of environmental rewarding cues, motivated behaviour and reward outcome.
### Instruction: Does mPGES-2 deletion remarkably enhance liver injury in streptozotocin-treated mice via induction of GLUT2? ### Response:
mPGES-2 deletion enhanced STZ-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus.
### Instruction: Does switching types of drug-eluting stents prevent repeated in-stent restenosis in patients with coronary drug-eluting stent restenosis? ### Response:
A strategy involving repeated DES implantation was superior to POBA for preventing recurrent restenosis. Treatment with a different type or generation of DES does not appear to reduce the incidence of TLR. Moreover, we identified certain useful factors for facilitating appropriate and early triage in the patients with repeated DES ISR.
### Instruction: Does change in adiposity minimally affect the lipid profile in youth with recent onset type 1 diabetes? ### Response:
Our data suggest that weight loss may be an effective, but limited, therapeutic approach for dyslipidemia in youth with T1D.
### Instruction: Is endoscopic gastric volume reduction with a novel articulating plication device safe and effective in the treatment of obesity ( with video )? ### Response:
Limited number of patients.
### Instruction: Is environmental lead exposure associated with visit-to-visit systolic blood pressure variability in the US adults? ### Response:
This study documents a positive linear relationship between environmental lead exposure and systolic blood pressure variability. Screening adults with fluctuating blood pressure for lead exposure could be warranted.
### Instruction: Are residual perfusion defects in patients with pulmonary embolism related to impaired fibrinolytic capacity? ### Response:
Prolonged time-to-diagnosis and fibrinolysis imbalance are independent predictors of incomplete perfusion recovery after acute PE.
### Instruction: Is chromogranin A a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas? ### Response:
CgA is a reliable serum diagnostic biomarker for PNETs but not for insulinomas.
### Instruction: Is expression of A disintegrin and metalloprotease 8 associated with cell growth and poor survival in colorectal cancer? ### Response:
Our results show that ADAM8 is overexpressed in CRC, promotes cell growth and correlates with worse OS and DFS, and thus could serve as a biomarker for individual CRC patient therapy.
### Instruction: Is functional recovery considered the most important target : a survey of dedicated professionals? ### Response:
Functional recovery, as in tolerance of food without nausea and regained mobility, was considered the most important target of recovery. There was a consistent uniformity in the way international dedicated professionals scored the relative importance of recovery targets and care items. The relative rating of the perioperative care items was not dependent on the strength of evidence supporting the items.
### Instruction: Does successive exposure to moderate hypoxia affect glucose metabolism and substrate oxidation in young healthy men? ### Response:
Seven hours of moderate hypoxia did not alter postprandial glucose responses or substrate oxidation in young healthy men.
### Instruction: Is the CCR5Δ32 allele a major predisposing factor for severe H1N1pdm09 infection? ### Response:
The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 infection or with a severe disease course.
### Instruction: Does repetitive electric brain stimulation reduce food intake in humans? ### Response:
Our study implies that the application of anodal direct currents to the right DLPFC represents a promising option for reducing both caloric intake and appetite in humans. This trial was registered at the German Clinical Trials Register (www.germanctr.de) as DRKS00005811.
### Instruction: Do progesterone receptor and PTEN expression predict survival in patients with low- and intermediate-grade pancreatic neuroendocrine tumors? ### Response:
Combined immunohistochemical assessment of PR and PTEN may help identify a small subset of PanNETs with more aggressive behavior and may aid in risk stratification.
### Instruction: Does the yeast histone chaperone hif1p function with RNA in nucleosome assembly? ### Response:
These results suggest that specific RNA species may function in concert with histone chaperones to assemble chromatin.
### Instruction: Do obese children and adolescents need increased gastric volumes in order to perceive satiety? ### Response:
Obese children and adolescents need to ingest greater volumes to feel full which may predispose toward the consumption of larger portion sizes. This may easily lead to overeating if predominantly energy-dense foods are consumed. A reduction in energy-dense foods in the diet of obese children and adolescents appears to be a necessary strategy for managing body weight.
### Instruction: Does anesthetic preconditioning inhibit isoflurane-mediated apoptosis in the developing rat brain? ### Response:
The ISO-mediated increase in cleaved caspase-3 in the postnatal day 7 rat brain is ameliorated by PC with a brief anesthetic exposure, and differences were not detected in other markers of neuronal injury.
### Instruction: Is cFI-rs7356506 a genetic protective factor for acute anterior uveitis in Chinese patients? ### Response:
This study has revealed a significant association between AAU and CFI-rs7356506, suggesting that CFI is involved in the pathogenesis of AAU, and that its influence on AAU may differ depending on gender and HLA-B27 status.
### Instruction: Is early elevated serum gamma glutamyl transpeptidase after liver transplantation associated with better survival? ### Response:
  These paradoxical findings may be explained by the time-dependent role of GGT in glutathione metabolism. Immediate postoperative elevation of GGT may indicate a physiological systemic response while chronic elevation reflects a pathological response.
### Instruction: Do sodium hypochlorite chemical burn in an endodontist 's eye during canal treatment using operating microscope? ### Response:
Sodium hypochlorite is an effective antibacterial irrigant indicated for the treatment of root canal infections. The tissue cytotoxicity highlights the need to inform the patient of the risk factors of accidents and enhance care with individual protection equipment for the patient and the professional during clinical procedures.
### Instruction: Is human fetal growth constrained below optimal for perinatal survival? ### Response:
From an immediate survival perspective, optimal fetal growth requires a birth weight between the 80(th) and 84(th) centiles for the population. Median birth weight in the population is, by definition, substantially lower than these centiles, implying that the majority of fetuses exhibit some form of maternal constraint on growth. This finding is consistent with adaptations that have evolved in humans in conjunction with a large head and bipedalism, to reduce the risk of obstructed delivery. These data also fit remarkably well with those on long-term adult cardiovascular and metabolic health risks, which are lowest in cases with a birth weight around the 90(th) centile.
### Instruction: Does zinc treatment ameliorate diarrhea and intestinal inflammation in undernourished rats? ### Response:
Altogether our findings provide novel mechanisms of zinc action in the setting of diarrhea and undernutrition and support the use of zinc to prevent the vicious cycle of malnutrition and diarrhea.
### Instruction: Does silibinin administration improve hepatic failure due to extensive liver infiltration in a breast cancer patient? ### Response:
This is the first case report of a clinical benefit of silibinin administration in a breast cancer patient.
### Instruction: Is spa typing alone sufficient to demonstrate endemic establishment of meticillin-resistant Staphylococcus aureus in a low-prevalence country? ### Response:
MRSA spa type t304 appears to have established itself as an endemic genetic lineage in the study area. spa typing does not provide sufficient resolution when investigating the spread of an endemic-like genetic lineage in a low-prevalence area, and should be supplemented by additional typing techniques.
### Instruction: Is total antioxidant capacity significantly lower in cocaine-dependent and methamphetamine-dependent patients relative to normal controls : results from a preliminary study? ### Response:
Stimulant-dependent patients had significantly lower antioxidant capacity relative to controls, suggesting that they may be at greater risk for oxidative damage to the brain and other organs.
### Instruction: Is neoplastic progression in short-segment Barrett 's oesophagus associated with impairment of chemical clearance , but not inadequate acid suppression by proton pump inhibitor therapy? ### Response:
Neoplastic progression in SSBO is associated with impairment of chemical clearance, but not inadequate acid suppression by PPI therapy. Neoplastic progression in SSBO can be predicted by a low PSPW index.
### Instruction: Does nADPH oxidase 2 mediate angiotensin II-dependent cellular arrhythmias via PKA and CaMKII? ### Response:
Ang II activates PKA and CaMKII via NOX2, which results in disturbed Na and Ca currents (via PKA) and enhanced diastolic SR Ca leakage (via CaMKII). Oxidative activation of PKA and CaMKII via NOX2 may represent important pro-arrhythmogenic pathways in the setting of increased Ang II stimulation, which may be relevant for the treatment of arrhythmias in cardiac disease.