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### Instruction: Is stemness Derived from Thyroid Cancer Cells? ### Response:
Our findings support our earlier hypothesis that stemness in thyroid cancer is derived via EMT rather than from resident thyroid stem cells. In mice with a thyroid-specific knock-in of oncogenic Braf (LSL-Braf((V600E))/TPO-Cre), the neoplastic changes were dependent on thyroid cell differentiation and the onset of stemness must have been derived from differentiated thyroid epithelial cells. Furthermore, celastrol suppressed TGF-β1 induced EMT in thyroid cancer cells and may have therapeutic potential.
### Instruction: Does low RNA translation activit limit the efficacy of hydrodynamic gene transfer to pig liver in vivo? ### Response:
The results suggest that the low activity of mRNA translation limits the final efficacy of the gene transfer procedure. On the other hand, the gold nanoparticles study suggests that elongated DNA conformation could offer advantages in that the access of 15-nm particles is very limited.
### Instruction: Is p300-dependent STAT3 acetylation necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells? ### Response:
p300-dependent STAT3 acetylation is necessary for Ang II-induced STAT3 phosphorylation and the consequent pro-fibrotic responses in renal tubular epithelial cells in vitro.
### Instruction: Is bevacizumab concomitant with chemotherapy effective in treating Chinese patients with advanced non-squamous non-small cell lung cancer? ### Response:
Bevacizumab concomitant with chemotherapy is effective and the related toxicity can be well tolerated in Chinese patients with NSNSCLC.
### Instruction: Does why TQM work in Iranian healthcare organisations? ### Response:
Understanding the factors that are likely to obstruct TQM implementation would enable managers to develop more viable strategies for achieving business excellence.
### Instruction: Do autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits? ### Response:
Our findings clearly demonstrate that Dlgap2 plays a vital role in social behaviors and proper synaptic functions of the OFC. Moreover, these results may provide valuable insights into the neuropathology of autism.
### Instruction: Does next-generation sequencing reveal large connected networks of intra-host HCV variants? ### Response:
Most intra-host variants are organized into distinct single-mutation components that are: well separated from each other, represent genetic distances between viral variants, robust to sampling, reproducible and likely seeded during transmission events. Facilitated by NGS, large components offer a novel evolutionary framework for genetic analysis of intra-host viral populations and understanding transmission, immune escape and drug resistance.
### Instruction: Does stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbate liver injury and fibrosis? ### Response:
We provide a novel role of Stat3 cooperating TGF-β1 in activation and anti-apoptotic effect of HSCs. Stat3 worsens liver fibrosis through the up-regulation of TGF-β1 and fibrotic product expression.
### Instruction: Does astragalin inhibit airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling? ### Response:
Astragalin ameliorated oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling. Therefore, astragalin may be a potent agent antagonizing endotoxin-induced oxidative stress leading to airway dysfunction and inflammation.
### Instruction: Is physical activity associated with elevated arterial stiffness in patients with lumbar disk herniation? ### Response:
The findings showed that LDH patients had higher baPWV levels. In addition, reduced physical activity was a risk factor contributing to increased baPWV. Further studies are warranted to determine the role of baPWV in LDH.
### Instruction: Does effective treatment with intravenous immunoglobulins reduce autoreactive T-cell response in patients with CIDP? ### Response:
Our data demonstrate that immunomodulatory treatment with IVIgs on a long-term basis reduces the autoreactive T-cell response against PMP-22 and P2-antigens, which may be influenced by the altered maintenance of CD8 and CD4 effector/memory T-cell subsets towards a more anti-inflammatory immune status. Elevated PMP-22 and P2-specific T-cell responses may serve as predictors for treatment responsiveness to IVIgs warranting validation in larger studies.
### Instruction: Does self-controlled practice enhance motor learning in introverts and extroverts? ### Response:
We conclude that self-controlled practice enhances motor learning in introverts and extroverts.
### Instruction: Does interatrial septum motion but not Doppler assessment predict elevated pulmonary capillary wedge pressure in patients undergoing cardiac surgery? ### Response:
Doppler assessment of PCWP was neither sensitive nor specific enough to be clinically useful in anesthetized patients with mechanical ventilation. The fixed curve pattern of the interatrial septum was the best predictor of raised PCWP.
### Instruction: Is hashimoto 's disease a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria? ### Response:
The comorbidity rate of HD in CSU patients was high, and such patients tended to have a positive ASST. Thyroid therapy in CSU patients with HD can lead to a considerable remission of urticarial symptoms, which may suggest that HD is possibly involved in the aetiology of CSU, or is at least a potential exacerbating factor for CSU.
### Instruction: Does gender difference affect the outcomes of eccentric rotational acetabular osteotomy used in hip dysplasia? ### Response:
The mean operative time and the blood loss were not significantly different between male and female patients. Postoperative CE angle tended to be smaller in male than female patients. The survival rate was not significantly different between males and females. Gender difference did not affect the clinical outcomes of ERAO in patients with hip dysplasia.
### Instruction: Is physician preference a major factor in management of vesicoureteral reflux? ### Response:
A surgeon's historic Deflux utilization was the most important predictor of VUR surgery type. Although data on reflux grade were not available, analysis of patient and surgeon characteristics suggests that surgeon preference is the first or second most critical factor in determining a patient's treatment.
### Instruction: Are filaggrin loss-of-function mutations a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate? ### Response:
The FLG loss-of-function mutation frequency was not significantly different between the AD and non-AD groups in a cohort of children from Ishigaki Island, which has a subtropical climate, suggesting that FLG loss-of-function mutations are not always a predisposing factor for AD prevalence.
### Instruction: Does administrative Database Research overestimate the Rate of Interval Colon Cancer? ### Response:
The prevalence of I-CRC at our institution before adjustment was comparable with previously reported rates. This proportion was 47% lower after adjusting for administrative errors placing our figure at the lower end of reported I-CRC incidence. Reported rates of I-CRC may be falsely elevated due to errors unique to merging administrative databases.
### Instruction: Does complement protein C1q promote macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins? ### Response:
C1q-polarization of macrophages toward an anti-inflammatory (M2-like) phenotype may be important in dampening inflammation in the early atherosclerotic lesion. Further investigation of molecular pathways targeted by C1q may provide novel therapeutic targets for this disease.
### Instruction: Does virtual planning of complex head and neck reconstruction result in satisfactory match between real outcomes and virtual models? ### Response:
Virtual plans for mandibular and maxillofacial reconstruction can be realised with excellent match.
### Instruction: Does an accelerated infliximab induction regimen reduce the need for early colectomy in patients with acute severe ulcerative colitis? ### Response:
In patients with ASUC, an accelerated infliximab induction strategy reduces the need for early colectomy. An intensified infliximab dosing strategy in response to clinical or laboratory signs of breakthrough inflammation merits consideration in prospective studies.
### Instruction: Does combination of dehydroepiandrosterone and orthovanadate administration reduce intestinal leukocyte recruitment in models of experimental sepsis? ### Response:
Our results indicate that DHEA is able to reduce intestinal leukocyte recruitment induced by experimental sepsis. Combination of DHEA with OV inhibits leukocyte adherence to intestinal endothelium, similar to what is achieved by the single administration of DHEA but with significantly improved FCD. These findings suggest a potential role for DHEA and OV in clinical sepsis.
### Instruction: Does psychological distress negatively affect self-assessment of shoulder function in patients with rotator cuff tears? ### Response:
Higher levels of psychological distress are associated with inferior baseline patient self-assessment of shoulder pain and function using the VAS, the Simple Shoulder Test, and the American Shoulder and Elbow Surgeons score. Longitudinal followup is warranted to clarify the relationship between distress and self-perceived disability and the effect of distress on postoperative outcomes after arthroscopic rotator cuff repair.
### Instruction: Does drought degree constrain the beneficial effects of a fungal endophyte on Atractylodes lancea? ### Response:
Plant traits plasticity was conferred by dual effects of drought stress and FEs, and these factors are interactive. Although FEs can help plants cope with drought stress, the beneficial effects are strictly constrained by drought degree.
### Instruction: Does inhibition of euchromatic histone methyltransferase 1 and 2 sensitize chronic myeloid leukemia cells to interferon treatment? ### Response:
Our study sheds light on the role of EHMT1 and EHMT2 as potential targets in improving the efficacy of standard treatments of CML.
### Instruction: Does cT substitute derived from MR images reconstructed with parallel imaging? ### Response:
SPIRiT marginally improved the CT substitute quality for a given number of radial spokes as compared to gridding. However, the increased reconstruction time of non-Cartesian parallel imaging reconstruction is difficult to motivate from this improvement. Because the CT substitute algorithm was insensitive to moderate subsampling, data for a CT substitute could be collected in as little as minute and reconstructed with gridding without deteriorating the CT substitute quality.
### Instruction: Does increased nucleated red blood cells count in prolonged rupture of membranes is not erythropoietin driven? ### Response:
Cord blood concentrations of EPO do not appear to be significantly affected by the duration of ruptured membranes. We speculate that erythropoiesis is upregulated in PROM by mechanisms that involve the production of cytokines and are not EPO driven.
### Instruction: Does [ Inflammation promote the development of colitis-associated colorectal cancer ]? ### Response:
Inflammation can promote the colitis-associated CAC. And the activation of STAT3 signal pathway may promote the development of CAC.
### Instruction: Is higher fructose intake inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults? ### Response:
Our cross-sectional results did not support the current hypothesis that high intake of fructose is associated with a higher prevalence of NAFLD as assessed by using the FLI and NAFLD liver fat score.
### Instruction: Does formononetin attenuate hydrogen peroxide ( H2O2 ) -induced apoptosis and NF-κB activation in RGC-5 cells? ### Response:
Formononetin may be developed as a antioxidant drug to treat diabetic retinopathy.
### Instruction: Does zuo Jin Wan reverse P-gp-mediated drug-resistance by inhibiting activation of the PI3K/Akt/NF-κB pathway? ### Response:
Our study has provided the first direct evidence that ZJW reverses drug-resistance in human colorectal cancer by blocking the PI3K/Akt/NF-κB signaling pathway, and could be considered as a useful drug for cancer therapy.
### Instruction: Do patients with Pathologically Proven Renal Disease Have Similar Declines in Renal Function Following Robot-Assisted Partial Nephrectomy? ### Response:
The presence of pathological renal disease in non-neoplastic renal tissue did not place patients at risk for worsened postoperative complications or renal function deterioration following robot-assisted partial nephrectomy.
### Instruction: Is neuronal loss an early component of subacute sclerosing panencephalitis? ### Response:
The combination of MRS and diffusion MRI findings suggests neuronal loss can be a primary target in rapidly or subacutely progressing SSPE, and preservation or regeneration of axonal structure may be beneficial in chronic cases.
### Instruction: Is osteoprotegerin a Better Serum Biomarker of Coronary Artery Calcification than Osteocalcin in Type 2 Diabetes? ### Response:
Our results suggest that OPG is a more useful serum biomarker than OC or ucOC for identifying those at increased risk of arterial calcification in type 2 diabetes.
### Instruction: Does inconsistency in filling in the bottom of the spine bone map affect reported spine bone mineral density? ### Response:
When there is a noticeable defect in the bottom of the spine bone map, filling this defect in consistently eliminates a significant source of variability in analysis of spine BMDs and might allow us to achieve smaller LSCs.
### Instruction: Does chronic intermittent hypobaric hypoxia ameliorate ischemia/reperfusion-induced calcium overload in heart via Na/Ca2+ exchanger in developing rats? ### Response:
These data suggest that CIHH protects developing rat hearts during I/R by enhancing the resistance against calcium overload and by preserving normal I(Na/Ca) and NCX1 protein. PKC activation might be involved in this protective process of CIHH.
### Instruction: Does diffusion-weighted MRI characteristics of the cerebral metastasis to brain boundary predict patient outcomes? ### Response:
DWI demonstrates changes in the tumor, across the tumor edge and in the peritumoral region which may not be visible on conventional MRI and this may be useful in predicting patient outcomes for operated cerebral metastases.
### Instruction: Is sumo E2 enzyme UBC9 required for efficient protein quality control in cardiomyocytes? ### Response:
UBC9 plays a significant role in cardiomyocyte protein quality control, and its activity can be exploited to reduce toxic levels of misfolded or aggregated proteins in cardiomyopathy.
### Instruction: Are spinal cord grey matter abnormalities associated with secondary progression and physical disability in multiple sclerosis? ### Response:
The study findings suggest that pathological involvement of the spinal cord GM contributes significantly to physical disability in relapse-onset MS and SPMS in particular.
### Instruction: Does age worsen the efficacy nor tolerance to combined induction therapies in locally advanced non-small cell lung cancer? ### Response:
Age by itself did not significantly worsen either the efficacy or tolerance to combined induction and definitive treatment in patients with LA-NSCLC and Eastern Cooperative Oncology Group performance status 0-2.
### Instruction: Do parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis-like cell death and DNA damage in cancer cells? ### Response:
In this study, methanolic extracts of Parmelia sulcata and Usnea filipendula induced apoptosis-like cell death by causing DNA damage, to cancer cells.
### Instruction: Is parathyroid hormone associated with the LV mass after aortic valve replacement? ### Response:
After AVR, the level of PTH is independently associated with LVH. In turn, the level of PTH is related with the renal function and the level of 25-OHD.
### Instruction: Does the conserved discs-large binding partner Banderuola regulate asymmetric cell division in Drosophila? ### Response:
Bnd is a novel regulator of ACD in different types of cells. Our data place Bnd at the top of the hierarchy of the factors involved in ACD, suggesting that its main function is to mediate the localization and function of the Dlg tumor suppressor. Bnd has an antioncogenic function that is redundant with Dlg, and the physical interaction between the two proteins is conserved in evolution.
### Instruction: Does pINK1 trigger autocatalytic activation of Parkin to specify cell fate decisions? ### Response:
Autocatalytic activation of Parkin bolsters its accumulation on mitochondria and apoptotic response to valinomycin. Our results suggest that PINK1-Parkin constitutes a damage-gated molecular switch that governs cellular-context-specific cell fate decisions in response to variable stress stimuli.
### Instruction: Do integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions? ### Response:
These observations suggest a working model for NA assembly whereby transient α-actinin-integrin complexes help nucleate NAs within the lamellipodium. Subsequently, integrin complexes containing kindlin, but not talin, emerge. Once NAs have formed, myosin II activity promotes talin association with the integrin-kindlin complex in a stoichiometry consistent with each talin molecule linking two integrin-kindlin complexes.
### Instruction: Does short-term glucocorticoid treatment cause spinal osteoporosis in ovariectomized rats? ### Response:
Short-term glucocorticoid treatment of ovariectomized rats indicates according to DEXA standards a severe osteoporotic bone status in vertebral bone. Nonetheless, dysfunctional bone anabolism and enhanced bone catabolism are observed. Alterations of bone extracellular matrix proteins that correlate to inferior mechanical stability and affected microstructure were noticed and suggest further investigation. Treatment with dexamethasone was also seen to affect insulin and osteopontin levels and thus osteoblast function and maturation. This described animal model presents a recapitulation of clinically obtained data from early phase glucocorticoid-induced osteoporosis observed in patients.
### Instruction: Does graft shape affect midfoot correction and forefoot loading mechanics in lateral column lengthening osteotomies? ### Response:
Graft shape had no effect on the correction of talonavicular abduction or dorsiflexion but did influence coronal plane motion and forefoot loading mechanics. Also, overcorrecting the abduction deformity was predictive of increased lateral plantar pressures.
### Instruction: Are iGF2 expression and β-catenin levels increased in Frozen Shoulder Syndrome? ### Response:
As in Dupuytren's disease, β-catenin levels and IGF2 expression are elevated in Frozen Shoulder Syndrome. These findings support the hypothesis that these connective tissue fibroses share a common pathophysiology.
### Instruction: Does comparative genomics of 274 Vibrio cholerae genomes reveal mobile functions structuring three niche dimensions? ### Response:
Our analysis revealed that genomic variations, in particular mobile functions including phages, prophages, transposable elements, and plasmids underlie the metadata structuring in each of the three niche dimensions. This underscores the role of phages and mobile elements as the most rapidly evolving elements in bacterial genomes, creating local endemicity (space), leading to temporal divergence (time), and allowing the invasion of new habitats. Together, we take a data-driven approach for comparative functional genomics that exploits high-volume genome sequencing and annotation, in conjunction with novel statistical and machine learning analyses to identify connections between genotype and phenotype on a genome-wide scale.
### Instruction: Does caffeine modify blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes? ### Response:
Supplementation with 1.5 mg/kg of caffeine reduces BG concentration during prolonged exercise in T2DM patients.
### Instruction: Is decrease in daytime sleeping associated with improvement in cognition after hospital discharge in older adults? ### Response:
Older adults whose daytime sleeping decreased after hospital discharge also experienced improvements in cognitive functioning at 6 month follow-up. As such, daytime sleep may represent a promising candidate for targeted interventions aimed at promoting cognitive recovery after hospital discharge.
### Instruction: Does co-Administration of Metformin and N-Acetyl Cysteine fail to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI? ### Response:
CONSIDERING THE ADVERSE EFFECT OF COMBINATION THERAPY, WE PROPOSED THE CONADMINISTRATION MIGHT HAVE NO BENEFICIAL EFFECT FOR PCOS PATIENT DURING COURSE OF OVULATION INDUCTION OF ICSI (REGISTRATION NUMBER: IRCT201204159476N1).
### Instruction: Is bone mineral content in patients with congenital generalized lipodystrophy unaffected by metreleptin replacement therapy? ### Response:
In contrast to rodent models, CGL patients have increased BMC in the leptin-deficient state, which does not change with leptin replacement. The high BMC in these patients is partially explained by high lean mass and tall stature.
### Instruction: Is p16 ( INK4a ) overexpression linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells? ### Response:
Our study shows a low prevalence of hr-HPVs in the urine of patients with high-grade urothelial malignancy. In those, p16(INK4a) overexpression occurs in the absence of demonstrable HPV DNA in the tissue sections, contrary to what is noted in gynecopathology.
### Instruction: Does the PROMIS physical function correlate with the QuickDASH in patients with upper extremity illness? ### Response:
The PROMIS Physical Function instrument may be used as an upper extremity disability measure, as it correlates with the QuickDASH questionnaire, and both instruments are influenced most strongly by the degree to which pain interferes with achieving goals.
### Instruction: Does multidisciplinary care improve amputation-free survival in patients with chronic critical limb ischemia? ### Response:
MDC pathways for the management of a population of CLI patients improved AFS by greater than twofold and should be the standard of care for the CLI population. Baseline nonambulatory status and unrevascularized patients also predict worse AFS. Wound healing remains prolonged regardless of preoperative or postoperative wound care. Future study is required to evaluate the costs and functional outcomes for MDC in the management of CLI.
### Instruction: Is unilateral hearing loss associated with a negative effect on language scores in adolescents? ### Response:
These findings suggest that UHL in adolescents is associated with a negative effect on standardized language scores and IQ. They also demonstrate that the developmental gap between children with UHL and children with NH does not resolve as the children progress into adolescence and may even widen as the children grow older. Therefore, these results strongly encourage implementation of early intervention for children with UHL to prevent speech-language delays. More studies in adolescents are warranted to evaluate educational outcomes.
### Instruction: Is initiation of nutritional support delayed in critically ill obese patients : a multicenter cohort study? ### Response:
The initiation of nutritional support was delayed in obese ICU patients. Randomized controlled trials that address consequences of early compared with delayed beginnings of nutritional support in critically ill obese patients are needed.
### Instruction: Does [ Gambogenic acid induce mitochondria-dependent apoptosis in human gastric carcinoma cell line ]? ### Response:
GNA induces mitochondria-dependent apoptosis and increases P53 expression in human gastric carcinoma cell line.
### Instruction: Is cigarette smoking associated with a reduction in the risk of incident gout : results from the Framingham Heart Study original cohort? ### Response:
Cigarette smoking is associated with lower incidence of gout and this is not explained by differences in the prevalence of risk factors. The mechanistic underpinnings of this epidemiological finding merits further study.
### Instruction: Does relative influence of genetics and shared environment on child mental health symptoms depend on comorbidity? ### Response:
We conclude that symptom classes are largely similar across sexes in middle childhood. Heritability was moderate for all classes, but shared environment played a greater role for classes in which no one type of symptom predominated.
### Instruction: Are prepregnancy body mass index and prenatal fasting glucose effective predictors of early postpartum metabolic syndrome in Spanish mothers with gestational diabetes? ### Response:
Women having GDM are at threat of early postpartum metabolic syndrome. This risk can be easily identified by assessing prepregnancy BMI and antenatal fasting glycemia in the first pregnancy visit.
### Instruction: Does glutamine depletion by crisantaspase hinder the growth of human hepatocellular carcinoma xenografts? ### Response:
The combination of Crisantaspase and MSO reduces glutamine supply to CTNNB1-mutated HCC xenografts and hinders their growth.
### Instruction: Is high expression of GTPase regulator associated with the focal adhesion kinase ( GRAF ) a favorable prognostic factor in acute myeloid leukemia? ### Response:
We provide evidence that high GRAF expression is a favorable prognostic marker in patients with AML.
### Instruction: Does progression rates and sample size estimate for PPMS based on the CLIMB study population? ### Response:
Our modern PPMS cohort is demographically similar to previously studied cohorts. PPMS is associated with faster disability accrual than ROMS. Current real-world observations of time to sustained progression will inform design of new clinical trials for PPMS.
### Instruction: Does microelectronic wear-time documentation of removable orthodontic devices detect heterogeneous wear behavior and individualizes treatment planning? ### Response:
Both the duration of daily wear time and the wear behavior need to be considered to individualize the prescription for wear time; this is made possible with microelectronic wear-time documentation. Individual prescription changes based on the wear-time documentation can be arranged with patients in a shared decision-making process to achieve effective and successful treatment progress.
### Instruction: Does protease-mediated human smooth muscle cell proliferation by urokinase require epidermal growth factor receptor transactivation by triple membrane signaling? ### Response:
In human coronary VSMC, uPA induces uPAR-independent, domain-dependent smooth muscle cell proliferation through transactivation of EGFR by a plasmin-mediated, ADAM-induced, and HB-EGF-dependent process, which is mediated by the intracellular pathways involving Gαi, Gβγ, src, and NAD(P)H oxidase.
### Instruction: Does evaluation and comparison of high-level microwave oven disinfection with chemical disinfection of dental gypsum cast? ### Response:
Within the limitation of this in vitro study, it was found that microwave disinfection of casts for 5 min at 900 W gives high-level disinfection that complies with the current infection control guidelines for the dental laboratory and microwave disinfection method is an effective and validated method as chemical disinfection. How to cite the article: Meghashri K, Kumar P, Prasad DK, Hegde R. Evaluation and comparison of high-level microwave oven disinfection with chemical disinfection of dental gypsum casts. J Int Oral Health 2014;6(3):56-60 .
### Instruction: Do neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro? ### Response:
These observations indicate that HF-NCSCs do not confer the same positive effect on β-cells as demonstrated for bNCSCs. Furthermore, these data suggest that induction of cadherin expression by HF-NCSCs may be useful for their ability to support β-cells in coculture and after transplantation.
### Instruction: Is exclusive breastfeeding duration during the first 6 months of life positively associated with length-for-age among infants 6-12 months old , in Mangochi district , Malawi? ### Response:
EBF in the first 6 months of life was associated with increased linear growth, but not weight gain, in later infancy. Promotion of EBF could reduce the prevalence of chronic child undernutrition in the study area.
### Instruction: Does the transcription factor Ap-1 regulate monkey 20α-hydroxysteroid dehydrogenase promoter activity in CHO cells? ### Response:
Our results indicate that the Ap-1 site (-281 → -274) (5'-TGTCTCAT-3') plays a crucial role in the activation of the monkey 20α-HSD gene. Thus, we demonstrated that monkey 20α-HSD promoter activity is regulated by the transcription factor Ap-1 in CHO-K1 cells.
### Instruction: Are anxiety Disorders Associated with Reduced Heart Rate Variability : A Meta-Analysis? ### Response:
Anxiety disorders are associated with reduced HRV, findings associated with a small-to-moderate effect size. Findings have important implications for future physical health and well-being of patients, highlighting a need for comprehensive cardiovascular risk reduction.
### Instruction: Do early results of a new rotating hinge knee implant? ### Response:
Our study shows excellent clinical results of the EnduRo TKA. Furthermore, no premature material failure or unusual biological response to the new bearing material could be detected.
### Instruction: Does [ Essential oil from Artemisia lavandulaefolia induce apoptosis and necrosis of HeLa cells ]? ### Response:
Essential oil from Artemisia lavadulaefolia can inhibit the proliferation of HeLa cells in vitro. Low concentration of essential oil from Artemisia lavadulaefolia can induce apoptosis, whereas high concentration of the compounds result in necrosis of HeLa cells. And,the mechanism may be related to the caspase-3-mediated-PARP apoptotic signal pathway.
### Instruction: Does targeted antiosteosarcoma methotrexate-bisphosphonate conjugate induce apoptosis of osteosarcoma cells in vitro? ### Response:
A targeted antiosteosarcoma methotrexate-bisphosphonate conjugate induces apoptosis in human osteosarcoma MG-63 cells. This new conjugate is a valuable experimental tool for the therapy of osteosarcoma.
### Instruction: Does activation of microbubbles by low-level therapeutic ultrasound enhance the antitumor effects of doxorubicin? ### Response:
MB-US could increase the susceptibility of tumours to antineoplastic drugs, suggesting a potential clinical method for US-mediated tumour chemotherapy.
### Instruction: Do dPP4 inhibitors increase differentially the expression of surfactant proteins in Fischer 344 rats? ### Response:
DPP4 inhibition influence differently the expression of surfactant proteins in healthy rats and may be suitable to elevate surfactant synthesis in different diseases accompanied with surfactant deficiencies.
### Instruction: Is desert dust a risk factor for the incidence of acute myocardial infarction in Western Japan? ### Response:
These data suggest that exposure to AD a few days before symptom onset is associated with the incidence of AMI.
### Instruction: Is photodynamic Therapy with 5 % δ-Aminolevulinic Acid Safe and Effective Treatment of Acne Vulgaris in Japanese Patients? ### Response:
Our protocol was effective for acne in Japanese and did not exhibit severe side effects.
### Instruction: Is [ `` Second look '' after laparoscopic myomectomy -- that a prevention of postoperative adhesions ]? ### Response:
The factors, responsible for the formation of postoperative adhesions are: the location of the myoma in the posterior uterine wall, excessive accumulation of suturing materials and additional operative interventions. For patients underwent LM and willing pregnancy we recommend second look laparoscopy.
### Instruction: Do evaluation of triple antibiotic paste removal by different irrigation procedures? ### Response:
Current irrigation techniques do not effectively remove TAP from root canal systems, possibly because of its penetration and binding into dentin. However, calcium hydroxide is effectively removed with significant less residual presence.
### Instruction: Does equisetum arvense ( common horsetail ) modulate the function of inflammatory immunocompetent cells? ### Response:
The data indicate that the used extract of Equisetum arvense interferes with the polyfunctionality of immunocompetent cells thereby providing an anti-inflammatory mode-of-action.
### Instruction: Does remote ischemic postconditioning protect against gastric mucosal lesions in rats? ### Response:
RIP provides effective functional protection and prevents cell injury to gastric tissue induced by limb IR via anti-inflammatory and antioxidant actions.
### Instruction: Is increased risk of radiographic emphysema in HIV associated with elevated soluble CD14 and nadir CD4? ### Response:
HIV is an independent risk factor for radiographic emphysema. Emphysema severity was significantly greater among participants with HIV infection. Among those with HIV, nadir CD4 < 200 cells/μL and elevated soluble CD14 level were associated with emphysema, highlighting potential mechanisms linking HIV with emphysema.
### Instruction: Does prevalence and correlate of unmet supportive care needs in patients with resected invasive cutaneous melanoma? ### Response:
Around a quarter of melanoma patients may have unmet support needs in the mid to long term after primary treatment. In particular, patients who are younger, less educated, distressed or socially isolated could benefit from more support.
### Instruction: Does dosimetric Inhomogeneity predict for Long-Term Breast Pain After Breast-Conserving Therapy? ### Response:
Long-term breast pain was common after BCT. Although nearly half of patients had pain, most considered it tolerable. Dosimetric inhomogeneity independently predicted for pain and should be minimized to the greatest extent possible.
### Instruction: Does short-term venous stasis induce fibrinolytic activation but not thrombin formation? ### Response:
We conclude that short-term venous stasis induces a profibrinolytic response due to the activation of endothelial cells, but not a prothrombotic response, even in the presence of additional thrombophilic risk factors. Furthermore, our results support the hypothesis that the stasis-induced profibrinolytic activation of endothelial cells occurs independently from thrombin formation.
### Instruction: Is carotid artery stenosis exacerbated in spontaneously obese model rats with diabetes? ### Response:
The OLETF rats were obese, and diabetes worsened the degree of carotid artery stenosis. These results indicate the possibility of new therapies for carotid artery stenosis in obese and diabetic patients.
### Instruction: Do silent polymorphisms in the RYR1 gene modify the phenotype of the p.4898 I > T pathogenic mutation in central core disease : a case report? ### Response:
Considering that patient's relatives showed no pathologic phenotype, and the phenotype presented by the patient is within the range observed in other central core disease patients with the same mutation, it was concluded that the c.14256 A > C polymorphism alone is not responsible for disease, and the associated additional silent polymorphisms are not acting as modifiers of the primary pathogenic mutation in the affected patient. The case described above illustrates the present reality where new methods for wide genome screening are becoming more accessible and able to identify a great variety of mutations and polymorphisms of unknown function in patients and their families.
### Instruction: Are flavones from Erythrina falcata modulators of fear memory? ### Response:
Our results demonstrate that vitexin, isovitexin and diosmetin-6-C-glucoside and flavonoidic fractions resulted in a significant retention of fear memory but did not prevent the extinction of fear memory. These results further substantiate that the treatment with pure flavonoids or flavanoid-rich fractions might represent potential therapeutic approaches for the treatment of neurocognitive disorders, improvement of memory acquisition and spontaneous recovery of fear.
### Instruction: Is wee1 a novel independent prognostic marker of poor survival in post-chemotherapy ovarian carcinoma effusions? ### Response:
Wee1 is frequently expressed in ovarian serous carcinoma effusions, and its expression is significantly higher following exposure to chemotherapy. The present study is the first to report that Wee1 is an independent prognostic marker in serous ovarian carcinoma.
### Instruction: Does carvacrol alleviate ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats? ### Response:
The results suggest that carvacrol could alleviate I/R-induced liver injury by its anti-oxidative and anti-apoptotic activities, and warrant a further investigation for using carvacrol to protect I/R injury in clinic.
### Instruction: Does chikungunya virus exploit miR-146a to regulate NF-κB pathway in human synovial fibroblasts? ### Response:
This study demonstrated the mechanism of exploitation of cellular miR-146a by CHIKV in modulating the host antiviral immune response in primary human synovial fibroblasts.
### Instruction: Do functional crosstalk between the mitochondrial PTP and KATP channels determine arrhythmic vulnerability to oxidative stress? ### Response:
Cardioprotection by CsA requires mKATP channel activation through a PKC-dependent pathway. Increasing mKATP activity during CsA administration is required for limiting OS-induced electrical dysfunction.
### Instruction: Are proliferation and differentiation of human adipose-derived mesenchymal stem cells ( ASCs ) into osteoblastic lineage passage dependent? ### Response:
Osteogenic potential of ASCs is impaired by successive passaging and may not serve as a useful clinical source of osteogenic ASCs past P2.
### Instruction: Is serotonin 5-HT7 receptor critically involved in acute and chronic inflammation of the gastrointestinal tract? ### Response:
The 5-HT7R expressed on CD11c/CD86-positive myeloid cells modulates the severity of intestinal inflammation in an acute and chronic colitis and thus represents a potential therapeutic target for the treatment of inflammatory disorders such as CD.
### Instruction: Does integration of proteomic and transcriptomic profiles identify a novel PDGF-MYC network in human smooth muscle cells? ### Response:
These findings provide the first systems-level analysis of the PDGF-regulated transcriptome and proteome in normal smooth muscle cells. The analyses revealed an extensive cohort of PDGF-dependent biological processes and connected key transcriptional effectors to their regulation, significantly expanding current knowledge of PDGF-stimulated signaling cascades. These observations also implicate MYC as a novel target for pharmacological intervention in fibroproliferative expansion of smooth muscle, and potentially in cancers in which PDGFR-dependent signaling or MYC activation promote tumor progression.
### Instruction: Is optimal dairy intake predicated on total , cardiovascular , and stroke mortalities in a Taiwanese cohort? ### Response:
In a Chinese food culture, a dairy foods intake in adults up to 7 times a week does not increase mortality and may have favorable effects on stroke.
### Instruction: Does intraoperative 3-D imaging improve sentinel lymph node biopsy in oral cancer? ### Response:
FhSPECT is a feasible technology that allows the accurate identification of SLNs in oral cancer. FhSPECT overcomes the shine-through phenomenon, one of the most important limitations of SLNB, thereby confirming the importance of SLNB in patients with cN0 oral cancer.
### Instruction: Is robot-assisted gait training superior to balance training for improving postural instability in patients with mild to moderate Parkinson 's disease : a single-blind randomized controlled trial? ### Response:
Our findings indicate that robotic gait training is not superior to balance training for improving postural instability in patients with mild to moderate Parkinson's disease.