question stringlengths 52 373 | long_answer stringlengths 1 3.34k |
|---|---|
### Instruction:
Does wBC reduction reduce storage-associated RBC adhesion to human vascular endothelial cells under conditions of continuous flow in vitro?
### Response:
| Prolonged storage of NWR RBCs increases RBC adherence to endothelial cells in vitro. WBC reduction before storage abrogates the effect of storage duration on increased adhesion. Studies to assess whether an in vivo effect occurs are required. |
### Instruction:
Does induction of aggrecanase 1 ( ADAM-TS4 ) by interleukin-1 occur through activation of constitutively produced protein?
### Response:
| These data support the hypothesis that ADAM-TS4 is constitutively produced in these cells and tissue, and that stimulation by IL-1 results in aggrecanase activation. Thus, the activator could be a potential target by which to control aggrecanase-mediated degradation in arthritic diseases. |
### Instruction:
Does plasma adiponectin play an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects?
### Response:
| Glimepiride remarkably improved insulin resistance, suggested by a significant reduction in HOMA-IR, an increase in MCR-g, and a reduction in HbA(1c) without changing extrapancreatic beta-cell function and urine CPR. Increased plasma adiponectin and decreased plasma TNF-alpha may underlie the improvement of insulin resistance with glimepiride. |
### Instruction:
Is micturition associated with phase III of the interdigestive migrating motor complex in man?
### Response:
| Micturition and phase III of the migrating motor complex are associated in time. |
### Instruction:
Do temporal patterns of caregiving for preterm infants indicate individualized developmental care?
### Response:
| Temporal patterns of caregiving reliably indicate individual differences, with sensitive and responsive caregiving common to typical NICU nursing environments. |
### Instruction:
Does site of care influence breastmilk feedings at NICU discharge?
### Response:
| Neonates admitted to NICUs are often discharged on feedings that do not include breastmilk. Beyond previously identified risk factors, site of care significantly influences this occurrence. |
### Instruction:
Is rectal ropivacaine absorbed proportionally to the dose , with low intraindividual variability?
### Response:
| Plasma drug concentrations were proportional to the dose after rectally administered doses corresponding to 50-200 mg ropivacaine base in a gel formulation. The drug was well-tolerated. Mean bioavailability was about 60% and not influenced by variations in the enema volume. Initial absorption seemed to follow zero-order kinetics and then first-order kinetics after about 4 h. Cmax and AUC showed considerably less intra- compared with inter-individual variability, resulting in more consistent plasma concentrations within subjects. |
### Instruction:
Are intravenous immunoglobulin-induced panel reactive antibody A reduction : not all preparations created equal?
### Response:
| Laboratory screening of IVIg preparations provides a rational basis for the selection of product for administration to patients in whom the aim is to produce a PRA reduction. Experiments involving protein-A treatment of IVIg preparations indicate that immunoglobulin G is the principal factor involved in the abrogation of serum reactivity. |
### Instruction:
Does combination of intravenously infused methylene blue and inhaled nitric oxide ameliorate endotoxin-induced lung injury in awake sheep?
### Response:
| In sheep, methylene blue/inhaled nitric oxide protects more efficiently against acute lung injury than inhaled nitric oxide alone, as indicated by a milder pulmonary hypertension, less extravascular lung water accumulation, and maintained gas exchange. |
### Instruction:
Does endothelin receptor antagonist bosentan improve microcirculatory blood flow in splanchnic organs in septic shock?
### Response:
| The endothelin receptor antagonist bosentan significantly improved microcirculatory blood flow in many splanchnic organs and in peripheral tissues during septic shock. The results of this study are consistent with the hypothesis that endothelin plays an important role in the regulation of microcirculatory blood flow in splanchnic as well as in peripheral tissues during septic shock. |
### Instruction:
Does mild hypothermia during hemorrhagic shock in rats improve survival without significant effects on inflammatory responses?
### Response:
| These data suggest that lipid peroxidation and systemic inflammatory responses to hemorrhagic shock are minimally influenced by mild hypothermia, although liver injury is mitigated and survival improved. Other mechanisms of benefit from mild hypothermia need to be explored. |
### Instruction:
Does low-dose terlipressin improve systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats?
### Response:
| Low-dose terlipressin in fluid-challenged endotoxic rats improved systemic and splanchnic hemodynamics and improved the ileal microcirculation. |
### Instruction:
Does expression of the DNA-PK binding protein E4-34K fail to confer radiation sensitivity to mammalian cells?
### Response:
| The lack of radiosensitization by E4-34k expression is quite intriguing as it is known that E4-34k interaction with DNA-PK(cs) causes disruption of V(D)J recombination, a process dependent on DSB rejoining. These data suggest that for future studies, preferential targeting of DNA-PK(cs) DSB activity will be required to influence cellular radiosensitivity. |
### Instruction:
Is laminin-5 gamma 2 chain colocalized with gelatinase-A ( MMP-2 ) and collagenase-3 ( MMP-13 ) in odontogenic keratocysts?
### Response:
| Our results indicate that the colocalization of Ln-5 with MMP-2 or MMP-13, but not with MMP-8, in BM zone of KCs, may be related to special characteristics of KC. |
### Instruction:
Does synthetic retinoid CD437 induce cell-dependent cycle arrest by differential regulation of cell cycle associated proteins?
### Response:
| CD437 profoundly suppressed the growth of gastric cancer cells, which was associated with cell-dependent induction of G0/G1 or G2/M arrest. The differential regulation of p21 that leads to alteration in the activity of cdks may play a critical role in cell-line-dependent regulation of cell cycle arrest following treatment with CD437. |
### Instruction:
Do aTPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells?
### Response:
| Since geldanamycin and radicicol are specific inhibitors of the ATPase in HSP90, the present result implies that ATPase activity in HSP90 plays some role in this apoptosis. |
### Instruction:
Is hsp70 present in human saliva?
### Response:
| Hsp70 is secreted to saliva, but unlike amylase is not transported by the exocytotic secretory mechanisms of acinar cells. Passive transport mechanisms of Hsp70 from blood serum or from salivary gland cells may be major routes of salivary Hsp70 secretion. |
### Instruction:
Does molecular strain typing of Trichophyton rubrum indicate multiple strain involvement in onychomycosis?
### Response:
| This preliminary study suggests that in many cases of fungal nail infection by T. rubrum, multiple strains are involved. This has important implications for epidemiological studies and possibly for therapy. |
### Instruction:
Is myocardial damage in falciparum malaria detectable by cardiac troponin T rare?
### Response:
| Assessed by troponin T, myocardial damage in falciparum malaria is rare. |
### Instruction:
Is aldose reductase gene polymorphism associated with progression of diabetic nephropathy in Japanese patients with type 1 diabetes mellitus?
### Response:
| Homozygosity for the Z+2 allele was associated with accelerated early progression of diabetic nephropathy in Japanese type 1 diabetic patients. |
### Instruction:
Does rosiglitazone ( PPARgamma-agonist ) attenuate atherogenesis with no effect on hyperglycaemia in a combined diabetes-atherosclerosis mouse model?
### Response:
| Rosiglitazone-treated animals showed less atherosclerosis despite higher lipid levels and similar glucose levels. These data suggest a direct anti-atherogenic effect of rosiglitazone on the arterial wall. |
### Instruction:
Is coverage of previously carious roots as predictable a procedure as coverage of intact roots?
### Response:
| These results indicate that coverage of previously carious roots with subepithelial connective tissue grafts is a very predictable procedure with results similar to those found on intact roots. This procedure may provide a definitive biological alternative for conventional restorative treatment modalities for root caries. Moreover, the results are more esthetic, biologically acceptable, and maintainable. |
### Instruction:
Does chronic antioxidant treatment improve sympathetic functions and beta-adrenergic pathway in the spontaneously hypertensive rats?
### Response:
| These results suggest that NAC and melatonin decreased the MAP and heart rate and improved the chronotropic response to isoproterenol in SHRs, in association with an inhibition of sympathetic activity and the restoration of cardiac beta-adrenoceptor function. |
### Instruction:
Does endovascular repair reduce early and late morbidity compared to open surgery for abdominal aortic aneurysm?
### Response:
| Endovascular stent-graft repair compared to open surgery has reduced the early and late morbidity by half. Complications that require invasive or secondary surgical procedures and hospitalization are reduced with endovascular repair. |
### Instruction:
Does overexpression of damaged-DNA-binding protein 2 ( DDB2 ) potentiate UV resistance in hamster V79 cells?
### Response:
| Our findings indicate that overexpression of DDB2 in V79 cell potentiates DNA repair and protects cells from UV-induced cytotoxicity. These results also suggest that DDB2 may be involved in the development of UV resistance. |
### Instruction:
Are adaptive changes in the rat hippocampal glutamatergic neurotransmission observed during long-term treatment with lorazepam?
### Response:
| Taken together, these changes strongly suggest that a compensatory increase in the glutamatergic response develops in the hippocampus during chronic treatment with LZ. Our findings might indicate a contribution of glutamatergic mechanisms to the tolerance to hippocampal-mediated effects of LZ, such as amnesic and anticonvulsant activities. |
### Instruction:
Does electrical and chemical stimulation of the basolateral complex of the amygdala reinstate cocaine-seeking behavior in the rat?
### Response:
| BLC stimulation is sufficient to reinstate cocaine-seeking behavior in the rat. These results are congruent with the hypothesis that the basolateral complex of the amygdala is part of a neural system mediating drug-seeking behavior. |
### Instruction:
Does achievement of steady state optimize results when performing indirect calorimetry?
### Response:
| These data support the use of steady state, best defined as an interval of 5 consecutive minutes whereby VO2 and VCO2 change by <10%. The mean REE from this period correlates best to the 24-hour TEE regardless of CV. IC testing can be completed after achievement of steady state. Activity factors of 10% to 15% should not be added to the steady-state REE, because this practice significantly decreases the accuracy. In patients who fail to achieve steady state, the CV helps to determine the appropriate duration of IC testing. In those patients with a low CV (< or = 9.0), 30-minute test duration is adequate. In patients with CV >9.0, test duration of at least 60 minutes may be required. These latter patients should be considered for 24-hour IC testing. |
### Instruction:
Do preoperative albumin and surgical site identify surgical risk for major postoperative complications?
### Response:
| Elective, non-emergent esophageal and pancreatic procedures performed in patients who could have had surgery delayed for preoperative nutrition, but did not, result in higher risk than colon surgery at any given level of serum albumin below 3.25 g/dL. Patient populations in trials should be stratified by operative site and by markers of nutritional status. Degree of hypoalbuminemia and other potential markers of nutritional status may explain many of the discrepancies between trials of nutrition support. Preexisting hypoalbuminemia in patients undergoing elective surgery remains underappreciated, unrecognized, and untreated in many hospitalized patients. |
### Instruction:
Does off-pump coronary artery bypass surgery reduce gastrointestinal complications?
### Response:
| Our study suggests that off-pump and on-pump techniques are similar in the rates of GI complications. We suggest that a properly designed randomized control trial is needed to verify our findings. |
### Instruction:
Does cardiac positioning using an apical suction device maintain beating heart hemodynamics?
### Response:
| DPS positioning significantly compromises hemodynamics due to reduced LV filling. The apical suction device provides good exposure with less hemodynamic compromise. |
### Instruction:
Is systolic blood pressure the main etiology for poorly controlled hypertension?
### Response:
| Systolic hypertension is the etiology of uncontrolled hypertension in the majority of patients. Currently available antihypertensive medications are less effective in controlling systolic hypertension. |
### Instruction:
Do human scleroderma sera contain autoantibodies to protein components specific to the U3 small nucleolar RNP complex?
### Response:
| Antifibrillarin autoantibodies are associated with autoantibodies to protein components specific to U3 snoRNP, particularly Mpp10. The prevalence of anti-Mpp10 antibodies in antifibrillarin-positive patients suggests that the U3 snoRNP particle is a source of immunogenic/antigenic material for the anti-snoRNP response in scleroderma. Autoantibodies to snoRNP components were more frequent in patients with diffuse scleroderma than in those with either the limited systemic or localized forms. The increased expression of these antibodies in patients with the more severe form of scleroderma, coupled with the observations that fibrillarin expression is positively linked to collagen expression in fibroblasts and that fibrillarin is overexpressed in scleroderma fibroblasts, suggests a source of snoRNP to initiate and maintain these autoantibody responses. |
### Instruction:
Are adenosine A2A or A3 receptors required for inhibition of inflammation by methotrexate and its analog MX-68?
### Response:
| These findings confirm that adenosine, acting at A(2A) and A(3) receptors, is a potent regulator of inflammation. Moreover, these results provide strong evidence that adenosine, acting at either or both of these receptors, mediates the antiinflammatory effects of methotrexate and its analog MX-68. |
### Instruction:
Does perinatal substance abuse intervention in obstetric clinics decrease adverse neonatal outcomes?
### Response:
| Improved neonatal outcomes were found among babies whose mothers received substance abuse treatment integrated with prenatal care. The babies of SAT women did as well as control infants on rates of assisted ventilation, low birth weight, and preterm delivery. They had lower rates of these three neonatal outcomes than infants of either SA or S women. |
### Instruction:
Does the aqueous extract of Solanum melongena inhibit PAR2 agonist-induced inflammation?
### Response:
| These results demonstrate that the SMWE inhibits PAR2 agonist-induced mouse paw edema. |
### Instruction:
Do developmental dyslexics show altered allocation of attention in visual classification tasks?
### Response:
| Results are discussed in the context of deviances in allocation of attentional resources in dyslexic readers. |
### Instruction:
Do task instructions modulate neural responses to fearful facial expressions?
### Response:
| Neural responses to fearful facial expressions are modulated by task instructions. |
### Instruction:
Is human albumin synthesis increased by an ultra-endurance trial?
### Response:
| The increase in the albumin synthetic rate the day after an ultra-endurance trial is a major event associated with a greater circulating protein mass. The impact of exercise on albumin synthesis has disappeared 8 d later, as did PV and total protein mass expansion. |
### Instruction:
Is differential production of adrenal steroids by purified cells of the human adrenal cortex relative rather than absolute?
### Response:
| Our findings are consistent with the concept that all adrenocortical cells are capable of producing a range of steroids, but the relative production of cortisol, androgen and aldosterone differs. |
### Instruction:
Does tissue Doppler echocardiography in patients with thalassaemia detect early myocardial dysfunction related to myocardial iron overload?
### Response:
| Wall motion abnormalities may represent an early sign of cardiac disease despite preserved global function. The regional abnormalities are related to iron overload and easily detectable with tissue Doppler echocardiography. |
### Instruction:
Do extra-nodal lymphoma presenting as a mimic of soft-tissue sarcoma?
### Response:
| The present series highlights a rare subgroup of patients with extra-nodal soft-tissue lymphoma mimicking soft-tissue sarcoma. Core biopsy is accurate in their diagnosis. Computed tomography scanning may show features suggesting the diagnosis. |
### Instruction:
Does [ Cell infiltration in nasal polyps and it 's pathological significance ]?
### Response:
| Infiltration of inflammatory effector cells such as eosinphils and chronic inflammatory changes of the nasal mucosa might play a role in nasal polyps sprouting. |
### Instruction:
Are questionnaires better than laboratory tests to screen for current alcohol abuse or dependence in a male inpatient population?
### Response:
| With a prevalence of 12.4%, our results are similar with other published studies for alcohol abuse and dependence according DSM criteria. The AUDIT as well as the Fiveshot seems to have the best diagnostic properties in this male medical inpatient population, and regarding to brief interventions, these questionnaires can be used as screening instruments as well as opportunities to talk about alcohol problems with admitted patients. |
### Instruction:
Does subconjunctival doxifluridine administration suppress rat choroidal neovascularization through activated thymidine phosphorylase?
### Response:
| TP may be involved in the formation of CNV. Subconjunctival injection of doxifluridine significantly reduced experimental CNV activity without apparent adverse effects. These results suggest the possibility that doxifluridine can be beneficial in treating CNV. |
### Instruction:
Is pancreatic leak after left pancreatectomy reduced following main pancreatic duct ligation?
### Response:
| Pancreatic leak remains a common complication after left pancreatectomy. The incidence of leak is reduced significantly when the pancreatic duct is identified and directly ligated during left pancreatectomy. |
### Instruction:
Does systemic inflammatory response predict survival following curative resection of colorectal cancer?
### Response:
| In patients who have undergone potentially curative resection for colorectal cancer, the presence of a systemic inflammatory response predicts a poor outcome. |
### Instruction:
Do membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain?
### Response:
| In view of these findings, we propose that the heme-binding cytochrome b5 domain served as a template for the evolution of membrane-associated binding pockets for non-heme ligands. |
### Instruction:
Does waist circumference predict metabolic cardiovascular risk in postmenopausal Chinese women?
### Response:
| Postmenopausal Chinese women with abdominal obesity may carry higher metabolic cardiovascular risk than those without it. It is WC, not BMI, that predicts metabolic cardiovascular risk factors in these women. |
### Instruction:
Are biological properties of biopsy specimens useful for predicting lymph node micrometastasis in esophageal carcinoma?
### Response:
| The expression of CD1 and DG1 in biopsy specimens may offer useful information on lymph node metastasis, including MM in esophageal carcinoma. |
### Instruction:
Is [ Junctional tachycardia in adolescents : nodal reentry the most frequent cause ]?
### Response:
| Nodal reentry is very common in adolescents and can explain symptoms ascribed to "spasmophilia", as well as some cases of malaise or syncope. |
### Instruction:
Do supraspinal antinociceptive effects of mu and delta agonists involve modulation of adenosine uptake?
### Response:
| The antinociceptive effects obtained with mu or delta (but not kappa) agonists administered supraspinally were indicative of the involvement of modulation of adenosine uptake. |
### Instruction:
Is thermogenesis inhibition in brown adipocytes a specific property of volatile anesthetics?
### Response:
| There are two distinct classes of anesthetics with regard to effects on thermogenesis, thermogenesis inhibitors and thermogenesis noninhibitors. The results are important for the interpretation of studies in thermal biology in general; specifically, they indicate that conclusions concerning regulation of nonshivering thermogenesis during anesthesia depend on the type of anesthetic used. Of clinical importance is that the volatile anesthetics are inhibitory for nonshivering thermogenesis and thus for an alternative heat production when myorelaxants prevent shivering. As the distinction between thermogenesis inhibitors and thermogenesis noninhibitors corresponds to the distinction between volatile and nonvolatile anesthetics, it may be related to the mode of action of the volatile anesthetics. |
### Instruction:
Does [ Ischemic preconditioning inhibit ischemia/reperfusion induced myocardial apoptosis in rabbits in vivo ]?
### Response:
| It suggests that ischemic preconditioning inhibits the rabbit myocardial apoptosis induced by ischemia/reperfusion in vivo. |
### Instruction:
Does the influence of platelet additive solutions on cytokine levels and complement activation in platelet concentrate during storage?
### Response:
| Our results indicate that replacing plasma in PC with unmodified PASIII for storage results in higher levels of platelet-derived cytokines in PC. Furthermore, it appears that the nature of the medium used for storage of PC has a significant impact on platelet activation and cytokine levels of the PC. These implications should be taken into account when considering replacement of plasma with PAS. |
### Instruction:
Does a flicker paradigm for inducing change blindness reveal alcohol and cannabis information processing biases in social users?
### Response:
| Alcohol and cannabis processing biases are found at levels of social use, have the potential to influence future consumption and for this reason merit further research. |
### Instruction:
Does the prevalence and correlate of gamma-hydroxybutyrate ( GHB ) overdose among Australian users?
### Response:
| GHB-related overdoses were common among a sample of GHB users who had only recently begun using the drug. The only apparent distinguishing factor between those who had and had not overdosed on GHB was the amount of experience with GHB use. |
### Instruction:
Is loss of self-inhibition a cellular mechanism for episodic rhythmic behavior?
### Response:
| By utilizing the same intrinsic member of a CPG network in both rhythm-generation and suppression, this system has developed a simple and efficient mechanism for generating a variable level of response to suit the animal's changing behavioral demands. |
### Instruction:
Are single-step adhesives permeable membranes?
### Response:
| These features resembled the 'overwet phenomenon' that was previously reported along the dentine-adhesive interfaces of some acetone-based three-step adhesives. The cured adhesive layer in single-step adhesives may act as semi-permeable membranes that allow water diffusion from the bonded hydrated dentine to the intermixed zone between the adhesive and the uncured composite. Osmotic blistering of water droplets along the surface of the cured adhesive layer and emulsion polymerisation of immiscible resin components probably account for the compromised bond strength in single-step adhesives after delayed activation of light-cured composites. |
### Instruction:
Does healthy older adults ' sleep predict all-cause mortality at 4 to 19 years of follow-up?
### Response:
| Older adults with specific EEG sleep characteristics have an excess risk of dying beyond that associated with age, gender, or medical burden. The findings suggest that interventions to optimize and protect older adults' sleep initiation, continuity, and quality may be warranted. |
### Instruction:
Is human polyomavirus DNA detected in Guthrie cards ( dried blood spots ) from children who developed acute lymphoblastic leukemia?
### Response:
| JCV or BKV were not found in any of the dried blood spots of children who later developed ALL or in the healthy controls. These findings suggest that it is unlikely that childhood ALL is associated with an in utero infection with JCV or BKV, although it is not possible to exclude an association with an in utero infection that has become latent in the kidneys with very low levels of circulating virus at birth. |
### Instruction:
Does disuse exaggerate the detrimental effects of alcohol on cortical bone?
### Response:
| Reduced weight bearing accentuates the detrimental effects of alcohol on cortical bone in adult male rats by further inhibiting bone formation. This finding suggests that reduced physical activity may be a comorbidity factor for osteoporosis in alcohol abusers. |
### Instruction:
Do development and testing of a rapid diagnostic test for bubonic and pneumonic plague?
### Response:
| Our RDT is a specific, sensitive, and reliable test that can easily be done by health workers at the patient's bedside, for the rapid diagnosis of pneumonic and bubonic plague. This test will be of key importance for the control of plague in endemic countries. |
### Instruction:
Is rNA interference a functional pathway with therapeutic potential in human myeloid leukemia cell lines?
### Response:
| RNAi is a functional pathway in human myeloid leukemia cell lines and combined RNAi of c-raf and bcl-2 genes may represent a novel approach to leukemia, providing a means to overcome the resistance to chemotherapeutic agents and ultimately to augment the efficacy of chemotherapy in myeloid leukemia. |
### Instruction:
Do basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers?
### Response:
| Our data suggest that HBV carriers with T1762/A1764 basal core promoter mutant are at increased risk for HCC and that this mutant may contribute to the pathogenesis of HBV infection. |
### Instruction:
Does chemokine and chemokine receptor gene expression indicate acute rejection of human cardiac transplants?
### Response:
| The expression of IP-10, Mig, I-TAC, RANTES, CXCR3, and CCR5 in cardiac allografts significantly correlates with the presence and grade of acute rejection. |
### Instruction:
Does low-dose ethanol attenuate gut ischemia/reperfusion-induced liver injury in rats via nitric oxide production?
### Response:
| These results suggest that low-dose ethanol attenuates the gut I/R-induced hepatic microvascular dysfunction and sequential liver injury by increasing sinusoidal NO levels. |
### Instruction:
Does lafutidine increase hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats?
### Response:
| These data suggest that lafutidine increases hepatic blood flow by sensitizing the liver to the action of central TRH via both capsaicin-sensitive sensory neurons and endogenous CGRP in urethane-anesthetized rats. |
### Instruction:
Does pSC 833 modulation of multidrug resistance to paclitaxel in cultured human ovarian carcinoma cells lead to apoptosis?
### Response:
| These results demonstrate the PSC 833 reduced the Pg-p-mediated multidrug resistance in human ovarian carcinoma cells to PTX-induced apoptosis in vitro. |
### Instruction:
Does selective COX-2 inhibition improve endothelial function in coronary artery disease?
### Response:
| This is the first study to demonstrate that selective COX-2 inhibition improves endothelium-dependent vasodilation and reduces low-grade chronic inflammation and oxidative stress in coronary artery disease. Thus, selective COX-2 inhibition holds the potential to beneficially impact outcome in patients with cardiovascular disease. |
### Instruction:
Are repeated administrations of interleukin ( IL ) -12 associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma , tumor necrosis factor-alpha , IL-6 , and IL-8 responses?
### Response:
| Induction of pro-inflammatory cytokines and associated fluctuations in leukocyte subset counts decrease on repeated administrations of rHuIL-12. The steady increment of IL-10 plasma levels may mediate the observed down-regulation of clinical and immunological effects. |
### Instruction:
Are hepatocyte growth factor receptor , matrix metalloproteinase-11 , tissue inhibitor of metalloproteinase-1 , and fibronectin up-regulated in papillary thyroid carcinoma : a cDNA and tissue microarray study?
### Response:
| Several novel and previously undetected tumor promoting/inhibiting genes may be of importance in the molecular pathogenesis and malignant progression of PTC. Transcription of these genes may result in overexpression of proteins, such as c-MET, MMP-11, TIMP-1, and FN, which may contribute to the pathogenesis of PTC. |
### Instruction:
Is the granulin-epithelin precursor/PC-cell-derived growth factor a growth factor for epithelial ovarian cancer?
### Response:
| cDNA library preparation from microdissected tumor epithelium provided a selective advantage for the identification of growth factors for epithelial ovarian cancer. Differential granulin expression in tumor samples and the antiproliferative effects of its antisense down-regulation suggest that GEP may be a new autocrine growth factor and molecular target for epithelial ovarian cancer. |
### Instruction:
Does lorazepam substitute for the alcohol stimulus in social drinkers?
### Response:
| These results are consistent with the pre-clinical literature and indicate the cross-species generality of the GABA(A) component of the alcohol discriminative stimulus. |
### Instruction:
Does ginkgo biloba leaf extract enhance levels of caspase-3 and amyloid precursor protein in normal rat hippocampus?
### Response:
| GbE can raise the levels of caspase-3 and APP in the hippocampus of normal rats. |
### Instruction:
Do total coumarins from fruits of Cnidium monnieri inhibit formation and differentiation of multinucleated osteoclasts of rats?
### Response:
| TCFC reduced the bone lose by decreasing the osteoclast formation, its TRAP activity, and osteoclastic bone resorption. |
### Instruction:
Are two polymorphisms in the fracalkine receptor CX3CR1 associated with peripheral arterial disease?
### Response:
| In this study we could not detect a difference in genotype frequencies of the V249I and T280M polymorphisms in CX(3)CR1 between PAD patients and controls. CAD concomitant with PAD was also not affected by the I- or the M-allele. |
### Instruction:
Does baclofen decrease acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH?
### Response:
| Baclofen reduces post-prandial acid and non-acid reflux and their associated symptoms. GABA B agonists may have a role in treating GERD. |
### Instruction:
Is expression of syndecan-1 a sensitive marker for cutaneous plasmacytoma?
### Response:
| Syndecan-1 was found to be a sensitive marker for plasmacytomas, independent of cytologic differentiation. |
### Instruction:
Do [ The effects of CDFI and CDE high-frequency ultrasonography on diagnosis of parotid neoplasm ]?
### Response:
| CDFI and CDE show an important clinical value in diagnosing parotid neoplasm. |
### Instruction:
Do animal study on expression of laminin and fibronectin in cornea during wound healing following alkali burn?
### Response:
| In the process of wound healing after alkali burn, the expression of laminin and fibronectin increases dramatically, which suggests that laminin and fibronectin may participate in the process of corneal wound healing. |
### Instruction:
Does emergency medical services screening of elderly fall in the home?
### Response:
| Prospective analysis is easily gathered and identifies elderly injuries and patterns. A significant number of elderly patients whose homes were visited by EMS need help. Retrospective analysis gleans little injury prevention information. |
### Instruction:
Do physicians vary in approaches to the clinical management of delirium?
### Response:
| The common selection of lorazepam to treat delirium is troubling because benzodiazepines themselves are implicated in delirium. Selection of an initial dose of haloperidol higher than that recommended for geriatric patients by more than half of the respondents is also of concern. There is a paucity of sound clinical evidence to guide the choice of pharmacological agents for treating delirium in older hospitalized patients. |
### Instruction:
Do myoblasts survive intracardiac transfer and divide further after transplantation?
### Response:
| Intravital fluorescence staining with PKH- 26 dye proved to be an easy and reliable method for identifying cells after cellular transplantation. Myoblasts survived an intracardiac transfer, regaining their physiologic structures and maintaining their ability for further cell division. |
### Instruction:
Are microemulsions highly effective anti-biofilm agents?
### Response:
| The results indicate that the microemulsions are highly effective antibiofilm agents. |
### Instruction:
Is community treatment with azithromycin for trachoma associated with antibiotic resistance in Streptococcus pneumoniae at 1 year?
### Response:
| The authors were unable to demonstrate that mass azithromycin therapy for trachoma produced macrolide resistant S pneumoniae that persists until the next scheduled annual treatment. |
### Instruction:
Does lower physician estimate of underlying asthma severity lead to undertreatment?
### Response:
| Physician estimates of underlying asthma severity appear to determine asthma care. For patients with inadequate symptom control, lower physician estimates of underlying severity were associated with care that is less consistent with national guidelines. To improve the quality of asthma care, physicians need to update treatment based on their patients' current symptoms and adapt care accordingly. |
### Instruction:
Does aAV-mediated expression of vascular endothelial growth factor induce choroidal neovascularization in rat?
### Response:
| In this study, a highly reproducible animal model of long-lasting CNV was developed. This model is being used to test antiangiogenic molecules to reduce or inhibit CNV and could be extended to primates. |
### Instruction:
Do effectiveness of chart prompt about immunizations in an urban health center?
### Response:
| The chart prompt increased on-time immunizations for some antigens. |
### Instruction:
Is quality of life in adults with end-stage renal disease since childhood only partially impaired?
### Response:
| Dialysis patients with paediatric ESRD have an impaired physical quality of life, but in contrast to dialysis patients with adult ESRD onset, they have a normal mental quality of life. |
### Instruction:
Does teriparatide have no effect on the calcium-mediated pharmacodynamics of digoxin?
### Response:
| Teriparatide, 20 microg subcutaneously, does not alter the cardiac effect of digoxin. |
### Instruction:
Is low p27Kip1 expression associated with poor prognosis in oral squamous cell carcinoma?
### Response:
| These results suggest that reduction of p27Kip1 plays an important role in the progression of oral SCC and is considered to be a useful prognostic factor in oral SCC patients. |
### Instruction:
Is expression of tissue factor associated with clinical features and angiogenesis in prostate cancer?
### Response:
| These results suggest that increased angiogenesis associated with TF expression might cause the metastasis and progression of prostate cancer. |
### Instruction:
Does [ Expression of vascular endothelial growth factor and tumor angiogenesis correlate with biological behaviors of nasopharyngeal carcinoma ]?
### Response:
| MVD and expression of VEGF are highly correlated with biological behaviors of NPC, which may serve as a parameter for determining tumor biological metastatic potential and prognosis. Angiogenesis inhibitors might be helpful in preventing NPC from metastasis. |
### Instruction:
Does activation of peripheral excitatory amino acid receptors decrease the duration of local anesthesia?
### Response:
| These results suggest that shortened lidocaine block durations observed after glutamate injection into the masseter muscle result from sensitization of afferent fibers as well as increases of peak extracellular water content and blood flow in masseter muscle. These effects of glutamate are mediated in part through activation of peripheral excitatory amino acid receptors. |
### Instruction:
Does the essential 26S proteasome subunit Rpn11 confer multidrug resistance to mammalian cells?
### Response:
| Rpn11-overexpression in mammalian cells affects cell proliferation and the response to cytotoxic drugs, both of which may promote tumor cell escape from chemotherapeutic agents, and may serve as a marker for MDR-cells. |
### Instruction:
Does prophylactic high dose methylprednisolone fail to treat severe decompression sickness in swine?
### Response:
| Prophylactic high dose MP exerts no protective effect against severe DCS and actually worsens mortality in this model. An earlier group of untreated controls (UC, n = 44, 30 DCS, 11 died, mean weight +/- SE = 19.9 +/- 0.3 kg) exposed to the same profile was also available for analysis. Comparison of the UC and NS animals suggested that pre-dive NS treatment may protect against severe DCS. |
### Instruction:
Do [ Plants and plant produce -- about plants as cause of diseases ]?
### Response:
| Doctors should be familiar with the term phytodermatoses and be aware of plants and plant products as possible causes of skin disorder. |
### Instruction:
Does maternal separation alter acquisition of ethanol intake in male ethanol-preferring AA rats?
### Response:
| We have previously shown that prolonged periods of maternal separation in Wistar rats result in an increased ethanol intake later in life. This was not repeated in this study, using AA rats with an inherent high ethanol intake. However, it is shown that brief maternal separation can delay acquisition of high ethanol intake and in addition decrease voluntary ethanol intake and preference in AA rats. Maternal separation for 15 min is therefore suggested to protect against high voluntary ethanol intake later in life. |
### Instruction:
Does acute systemic inflammation enhance endothelium-dependent tissue plasminogen activator release in men?
### Response:
| Our results showed that acute systemic inflammation augmented local forearm t-PA release in men, which suggests that acute inflammation may invoke a protective response by enhancing the acute endogenous fibrinolytic capacity in healthy men. Further studies are needed to clarify whether this response is impaired in patients with cardiovascular disease. |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.