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### Instruction:
Is a variant at chromosome 9p21 associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome : the GRACE Genetics Study?
### Response:
| In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS. |
### Instruction:
Is advanced chronic venous insufficiency associated with increased calf muscle deoxygenation?
### Response:
| These results suggest that FI and RI, as measured by NIRS, may be promising parameters for discriminating early CVI from advanced CVI. |
### Instruction:
Does anaesthetic specialisation lead to improved early- and medium-term survival following major vascular surgery?
### Response:
| Anaesthetic specialisation reduced early- and medium-term mortality rates following major vascular surgery. If replicated by prospective studies, these results suggest that vascular surgery services would benefit from specialised anaesthetic support. |
### Instruction:
Do implant-supported single crowns predictably survive to five years with limited complications?
### Response:
| From the presented data it may be concluded that 5-year survival of implant-supported single crowns is high, although biologic and mechanical complications are anticipated. |
### Instruction:
Does upregulation of SOCS-3 and PIAS-3 impair IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users?
### Response:
| These findings provide compelling in vivo evidence that heroin use or heroin use plus HCV infection impairs CD56(+) T cell-mediated innate immune function, which may account for HCV infection and persistence in liver. |
### Instruction:
Does a novel DNA gyrase inhibitor rescue Escherichia coli dnaAcos mutant cells from lethal hyperinitiation?
### Response:
| These findings indicate that a screening with SF53 will be able to identify compounds that also target other replication proteins (in addition to DnaA). Screening of LOPAC with SF53 cells led to the discovery of a novel DNA gyrase inhibitor. |
### Instruction:
Are implant location and radiotherapy the only factors linked to 2-year implant failure?
### Response:
| The authors concluded that late implant failure was influenced by the local factor "implant location" and the systemic factor "radiotherapy." Neither smoking nor systemic health factors were found to adversely influence implant integration from abutment connection through 2 years' performance. |
### Instruction:
Do the use of mandibular implant-retained overdentures improve patient satisfaction and quality of life?
### Response:
| The analyses illustrate that patient general satisfaction and oral health-related QOL are greater with mandibular implant-retained overdentures than conventional dentures, but the magnitude of these effects remain uncertain, and heterogeneity of outcomes was observed. The review sheds no new light on the effect of the treatment on general health related QOL. |
### Instruction:
Do elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis?
### Response:
| Our results indicate that elevated immune responses toward EBNA1 are selectively increased in CIS patients and suggest that EBNA1-specific IgG titers could be used as a prognostic marker for disease conversion and disability progression. |
### Instruction:
Is physical activity during pregnancy associated with reduced fasting insulin -- the Pilot Pregnancy and Active Living Study?
### Response:
| Our findings suggest that increased total physical activity is associated with reduced fasting insulin levels in overweight or obese pregnant women. |
### Instruction:
Is passive leg-raise helpful to identify impaired diastolic functional reserve during exercise in patients with abnormal myocardial relaxation?
### Response:
| Passive leg raise might be helpful in identifying a subgroup with lower diastolic functional reserve and lower exercise capacity among patients with abnormal relaxation. |
### Instruction:
Do women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation?
### Response:
| Women with MIFs or RPLs have increased T cell activation in peripheral blood lymphocytes, and T cell suppressor activation seems to be associated with decreased Th1 immunity. Further studies on T cell activation may elucidate molecular mechanisms controlling Th1 effectors. |
### Instruction:
Is weekly bortezomib , pegylated liposomal doxorubicin , and dexamethasone a safe and effective therapy for elderly patients with relapsed/refractory multiple myeloma?
### Response:
| Bortezomib/ PLD/dexamethasone combination is safe and effective in elderly patients with resistant-relapsing MM. |
### Instruction:
Does inhibition of angiotensin-converting enzyme stimulate fracture healing and periosteal callus formation - role of a local renin-angiotensin system?
### Response:
| Our study provides evidence for a local RAS in bone that influenced the process of fracture healing. We show for the first time that inhibition of ACE is capable of accelerating bone healing and remodelling. |
### Instruction:
Does narrow band imaging cystoscopy improve the detection of non-muscle-invasive bladder cancer?
### Response:
| NBI cystoscopy improves the detection of primary and recurrent nonmuscle invasive bladder cancer over WLI. However, further validation of the technique with comparative studies is required. |
### Instruction:
Is ondansetron as effective as diphenhydramine for treatment of morphine-induced pruritus after cesarean delivery?
### Response:
| Ondansetron is as effective as diphenhydramine in relieving pruritus caused by SA morphine in patients undergoing a cesarean delivery. However, up to 50% of patients required naloxone either for primary failure or for recurrence. |
### Instruction:
Are language and motor skills impaired in infants with biliary atresia before transplantation?
### Response:
| Very young children with biliary atresia display a characteristic profile of early developmental deficits before transplantation. These findings suggest that early intervention and aggressive nutritional management should be the standard of care to minimize neurocognitive effects. |
### Instruction:
Is time for initial response to steroids a major prognostic factor in idiopathic nephrotic syndrome?
### Response:
| The interval from onset of steroid therapy to remission is an accurate early prognostic factor in INS. |
### Instruction:
Is maternal interleukin-6 ( -174 ) C/C polymorphism associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant?
### Response:
| Frequencies of the IL-6 G(-174)C polymorphisms did not differ between groups. Subgroup analysis revealed an association of the CC genotype with CCA and cPVL in the preterm newborn. |
### Instruction:
Do determinants of frequency and longevity of hospital encounters ' data use?
### Response:
| The usage of past patient information varied significantly according to patient age, type of information, type of hospital encounter and medical cause (main diagnosis) for the encounter. The exponential model is a good fit to model how the reports are seen over time, so the design of user interfaces and repository management algorithms should take it in consideration. |
### Instruction:
Is specificity protein 2 ( Sp2 ) essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts?
### Response:
| Our results demonstrate that Sp2 is essential for early mouse development and autonomous proliferation of MEFs in culture. Comparison of the Sp2 knockout phenotype with the phenotypes of Sp1, Sp3 and Sp4 knockout strains shows that, despite their structural similarity and evolutionary relationship, all four glutamine-rich members of the Sp family of transcription factors have distinct non-redundant functions in vivo. |
### Instruction:
Does mosaic structure of intragenic repetitive elements in histone H1-like protein Hc2 vary within serovars of Chlamydia trachomatis?
### Response:
| The polymorphisms in Hc2 need to be further investigated in experimental studies since DNA binding is essential for the unique biphasic life cycle of the Chlamydiacae. The high sequence variation in the corresponding hctB gene enables phylogenetic analysis and provides a suitable target for the genotyping of C. trachomatis. |
### Instruction:
Is geographic access to care a determinant of child mortality in a rural Kenyan setting with high health facility density?
### Response:
| Significant spatial variations in mortality were observed across the area, but were not correlated with distance to health facilities. We conclude that given the present density of health facilities in Kenya, geographic access to curative services does not influence population-level mortality. |
### Instruction:
Does caffeine protect against alcoholic liver injury by attenuating inflammatory response and oxidative stress?
### Response:
| These findings suggest that caffeine may represent a novel, protective strategy against alcoholic liver injury by attenuating oxidative stress and inflammatory response. |
### Instruction:
Are tax gene expression and cell cycling but not cell death selected during HTLV-1 infection in vivo?
### Response:
| Therefore, virus-cell interactions alone are not sufficient to initiate early leukemogenesis in vivo. |
### Instruction:
Does transitory activation of AMPK at reperfusion protect the ischaemic-reperfused rat myocardium against infarction?
### Response:
| Our data demonstrated that, in our ex vivo model of myocardial ischaemia-reperfusion injury, AMPK activation in early reperfusion is associated with a reduction in infarct size. |
### Instruction:
Does alcohol slow the brain potential associated with cognitive reaction time to an omitted stimulus?
### Response:
| The similarity between alcohol effects on premotor reaction time and some parameters of the OSP supports the importance of examining how other environmental and pharmacological factors known to alter premotor reaction time might change components of the OSP and other types of event-related potentials. |
### Instruction:
Is aminoterminal propeptide of type III procollagen ( PIIINP ) associated with ascending aortic aneurysm growth rate?
### Response:
| Our results suggest that it may in the future be possible to monitor TAA growth by means of PIIINP levels. |
### Instruction:
Does hormone therapy affect plasma measures of factor VII-activating protease in younger postmenopausal women?
### Response:
| HT increases the plasma measures of FSAP. This increase may contribute to the protective effect on CHD induced by HT in younger postmenopausal women. |
### Instruction:
Is reduced expression of EphB2 significantly associated with nodal metastasis in Chinese patients with gastric cancer?
### Response:
| Frequent deletion and decreased expression of EphB2 protein suggested it as a negative biomarker for gastric carcinogenesis and a potential predictor of the outcome of patients with gastric cancer. |
### Instruction:
Does volume of blood suctioned during vacuum-assisted breast biopsy predict later hematoma formation?
### Response:
| The likelihood of hematoma is increasing along with increasing amount of blood suctioned, reaching a plateau approximately at 80 cc of blood lost. |
### Instruction:
Is valsartan addition to amlodipine more effective than losartan addition in hypertensive patients inadequately controlled by amlodipine?
### Response:
| Valsartan 160 mg plus amlodipine 5 mg produced greater BP reductions than losartan 100 mg plus amlodipine 5 mg. |
### Instruction:
Does apocynin restore endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions?
### Response:
| NADPH oxidase expression is increased in diabetic rat aorta. NADPH oxidase-mediated oxidative stress is accompanied by the decreased eNOS and increased iNOS expressions, contributing to endothelial dysfunction. Apocynin effectively prevents the increased NADPH oxidase expression in diabetic aorta and restores the alterations in NOS expression, blocking the vicious cycle leading to diabetes-associated endothelial dysfunction. |
### Instruction:
Does phospholipase D1 mediate AMP-activated protein kinase signaling for glucose uptake?
### Response:
| These results suggest that AMPK-mediated PLD1 activation is required for (14)C-glucose uptake through ERK stimulation. We propose that the AMPK-mediated PLD1 pathway may provide crucial clues to understanding the mechanisms involved in glucose uptake. |
### Instruction:
Do dental implant outcomes may vary in patients with a history of periodontal disease?
### Response:
| The authors suggest there is "some evidence" that patients treated for periodontitis may experience more implant loss and complications around implants than patients without periodontitis. |
### Instruction:
Do survival rates of all-ceramic systems differ by clinical indication and fabrication method?
### Response:
| The authors suggest that many all-ceramic restorations were found to demonstrate acceptable longevity compared with conventional restorations (eg, metal-ceramic crowns). For single-rooted anterior teeth, broad support was found for the premise that clinicians may select from any all-ceramic system for laminate veneers, intracoronal restorations such as inlays and onlays, and for full-coverage restorations. For restoration of molar teeth, the review suggests that relatively few all-ceramic systems will provide predictable long-term success. The number of clinical complications with all-ceramic fixed dental prostheses (multiunit) remains high, even with increased connector size. Although zirconium systems offer the advantage of favorable material characteristics for substructures, the clinical problem of chipping of the weaker esthetic veneer persists. |
### Instruction:
Does neuromuscular and cardiac comorbidity determine survival in 140 patients with left ventricular hypertrabeculation/noncompaction?
### Response:
| Mortality in LVHT is high and due to cardiac and neuromuscular comorbidity, why monitoring and therapy, including device therapy, should be improved. |
### Instruction:
Do association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells?
### Response:
| If CAC mobilization and wound perfusion are important determinants of clinical outcome, then strategies designed to augment angiogenic responses may improve outcome in patients with severe burn wounds. |
### Instruction:
Are allelic variations in angiogenic pathway genes associated with preeclampsia?
### Response:
| Allelic variations in the fms-like tyrosine kinase 1 and vascular endothelial growth factor C genes are associated with preeclampsia in both ethnic groups. |
### Instruction:
Does simulation-based training improve physicians ' performance in patient care in high-stakes clinical setting of cardiac surgery?
### Response:
| Skills required to wean a patient from CPB can be acquired through simulation-based training. Compared with traditional interactive seminars, simulation-based training leads to improved performance in patient care by senior trainees in anesthesiology. |
### Instruction:
Does combination therapy of calcium channel blocker and angiotensin II receptor blocker reduce augmentation index in hypertensive patients?
### Response:
| The results suggest that azelnidipine has a more beneficial effect on vascular properties in combination therapy with ARB than trichlormethiazide. |
### Instruction:
Do maximal sterile barrier precautions reduce catheter-related bloodstream infections in general surgery units : a multi-institutional randomized controlled trial?
### Response:
| This study is larger in sample size than the one performed by Raad et al and could not demonstrate better prevention of CRBSIs by MSBP compared with SSBP. A large randomized controlled trial or at least a meta-analysis of any other studies in the literature is necessary to reach to a conclusion on this issue. |
### Instruction:
Do people with recurrent low back pain respond differently to trunk loading despite remission from symptoms?
### Response:
| Despite symptom remission, DM EMG during predictable loading and DM and SM EMG during unpredictable loading were less in people with recurrent LBP than healthy participants. |
### Instruction:
Does type I gore-tex laryngoplasty for glottic incompetence in mobile vocal fold?
### Response:
| Gore-tex thyroplasty provides reliable medium-term improvement in both perceptual and subjective voice parameters in the setting of GI with mobile vocal folds. |
### Instruction:
Does gene expression profiling define the role of ATP-exposed keratinocytes in skin inflammation?
### Response:
| These studies characterized (1) STAT3 activation, (2) chemotaxis for neutrophils via CXCL1-3, and (3) ATF3 activation as possible roles of ATP-stimulated keratinocytes in skin inflammation and immune response. |
### Instruction:
Is anal cancer maximum F-18 fluorodeoxyglucose uptake on positron emission tomography correlated with prognosis?
### Response:
| SUV(max) is a valuable biomarker of anal cancer prognosis, predicting increased risk of lymph node metastasis and worse disease-free survival. |
### Instruction:
Does immunotherapy with a Phleum pratense allergen extract induce an immune response to a grass-mix allergen extract?
### Response:
| Patients with rhinoconjunctivitis diagnosed using skin prick testing with a grass mix allergen extract and treated with a short course of SIT based on a single species P. pratense allergen extract are able to develop an immune response that targets not only the immunizing species, but also the grass mix allergen extract. |
### Instruction:
Do marrow-derived MSCs and atorvastatin improve cardiac function in rat model of AMI?
### Response:
| These results suggest that either atorvastatin or MSCs cannot individually improve ventricular function significantly. However, atorvastatin synergistically enhanced the beneficial effects of MSCs in the treatment of AMI. |
### Instruction:
Is toll-like receptor 6 Ser249Pro polymorphism associated with lower left ventricular wall thickness and inflammatory response in hypertensive women?
### Response:
| These data suggest that hypertensive women homozygous for the TLR6 249Ser polymorphism might exhibit lower LV wall thickness and reduced TLR6-mediated inflammatory response than females carrying the major allele. |
### Instruction:
Is apoptosis involved in the mechanism of myocardial dysfunction after resuscitation in a rat model of cardiac arrest and cardiopulmonary resuscitation?
### Response:
| Myocardial function was significantly impaired after cardiac arrest/cardiopulmonary resuscitation and ischemia/reperfusion. However, apoptosis was not involved in the mechanism of postresuscitation myocardial dysfunction in this setting. |
### Instruction:
Is increased affinity to canalicular P-gp via formation of lipophilic ion-pair complexes with endogenous bile salts associated with mw threshold in hepatobiliary excretion of quaternary ammonium compounds?
### Response:
| Mw-dependent binding of QACs to canalicular P-gp contributes in part to the mechanism of the Mw threshold of 200 +/- 50. The formation of lipophilic ion-pair complexes with bile salts, followed by stronger binding to canalicular P-gp, appears to accelerate biliary excretion of QACs with a high Mw. |
### Instruction:
Is gastrogastric fistula following Roux-en-Y bypass attributed to both surgical technique and experience?
### Response:
| GGF was only identified in undivided RGB. The occurrence decreased with increasing surgical experience. Together, overall surgical technique in addition to gastric division must play a role in fistula formation. |
### Instruction:
Does radiographic stability of ingrowth humeral stem in total shoulder arthroplasty?
### Response:
| Proximally coated humeral stems for TSA showed few radiolucencies and no loosening at short- to midterm followup, reflecting an improvement over previous series. We now use these stems for primary TSAs and reserve cemented stems only when uncemented fixation is not possible owing to bony deficiency. |
### Instruction:
Does protein C inhibitor regulate both cathepsin L activity and cell-mediated tumor cell migration?
### Response:
| Overall, our data show that PCI regulates tumor cell migration partly by inhibiting cathepsin L. |
### Instruction:
Do [ Epidemiology of substance use and substance use disorders in Germany ]?
### Response:
| The availability of nicotine and pharmaceutical dependence assistance to patients should be improved in the primary and secondary care systems. The alcohol abuse of adolescents requires specific observation and intervention. In order to adequately plan treatment systems for addiction, an estimation of the need for help and the acceptance of the help should be explored and analyzed in scientific studies. |
### Instruction:
Does opioid receptor agonist reduce myocardial ischemic injury when administered during early phase of myocardial ischemia?
### Response:
| In this model, the severity of postischemic myocardial dysfunction was less when the heart was protected during ischemia. Ischemia injury may therefore be the major cause of postresuscitation myocardial dysfunction. |
### Instruction:
Is two-thumb technique superior to two-finger technique during lone rescuer infant manikin CPR?
### Response:
| Healthcare providers required 0.6s longer time to deliver two breaths during two-thumb lone rescuer infant CPR, but there was no significant difference in percent effective breaths delivered between the two techniques. Two-thumb CPR had 4 fewer delivered compressions per minute, which may be offset by far more effective compression depth and compression pressure compared to two-finger technique. |
### Instruction:
Does large-scale transcriptome data reveal transcriptional activity of fission yeast LTR retrotransposons?
### Response:
| Presumably, the host organism negatively regulates proliferation of LTR retrotransposons. The finding of considerable transcriptional activity of retrotransposons suggests that part of this regulation is likely to take place at a post-transcriptional level. Alternatively, the transcriptional activity may signify a hitherto unrecognized activity level of retrotransposon proliferation. Our findings underline the usefulness of transcriptome data in elucidating dynamics in retrotransposon transcription. |
### Instruction:
Does polypyrimidine tract binding protein function as a negative regulator of feline calicivirus translation?
### Response:
| Our data indicates that PTB may function to negatively regulate FCV translation initiation. To reconcile this with efficient virus replication in cells, we propose a putative model for the function of PTB in the FCV life cycle. It is possible that during the early stages of infection, viral RNA is translated in the absence of PTB, however, as the levels of viral proteins increase, the nuclear-cytoplasmic shuttling of PTB is altered, increasing the cytoplasmic levels of PTB, inhibiting viral translation. Whether PTB acts directly to repress translation initiation or via the recruitment of other factors remains to be determined but this may contribute to the stimulation of viral RNA replication via clearance of ribosomes from viral RNA. |
### Instruction:
Does glycaemic status influence the nature and severity of coronary artery disease?
### Response:
| Fasting blood glucose, HbA1c and the presence of diabetes are associated with the severity and progression of coronary atherosclerosis. These observations support the hypothesis that better glycaemic control may favourably influence CAD in patients with abnormal glucose tolerance or diabetes. |
### Instruction:
Is impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance the dominant defect in glucose intolerance?
### Response:
| Insulin resistance normally upregulates the secretory tone, with no evidence of defective compensation in IGR. In contrast, beta cell glucose sensitivity is independent of insulin resistance, but a key determinant of glucose tolerance. This suggests that hyperglycaemia results from an intrinsic beta cell defect rather than from inadequate compensation for insulin resistance. |
### Instruction:
Does glucagon-like peptide-1 receptor signalling selectively regulate murine lymphocyte proliferation and maintenance of peripheral regulatory T cells?
### Response:
| These studies establish that GLP-1R signalling may regulate lymphocyte proliferation and maintenance of peripheral regulatory T cells. |
### Instruction:
Is initial colony morphology-based selection for iPS cells derived from adult fibroblasts substantially improved by temporary UTF1-based selection?
### Response:
| Our data indicate that temporary selection using a genetic UTF1-based system can generate homogenous pluripotent iPS cells that can be maintained without permanent selection pressure. |
### Instruction:
Is a functional polymorphism in the disrupted-in schizophrenia 1 gene associated with chronic fatigue syndrome?
### Response:
| DISC1 Ser704Cys might be a functional variant that affects one of the mechanisms implicated in the biology of CFS. Some patients with CFS showed a phenotype similar to that of patients with MDD, but further studies are needed to clarify the biological mechanism, because this study is of a rather preliminary nature. Despite the variety of patients with CFS, DISC1 Ser704Cys has an association with CFS, which may also suggest that DISC1 plays a central role in the induction of various psychiatric diseases. |
### Instruction:
Do random texts exhibit the real Zipf 's law-like rank distribution?
### Response:
| The good fit of random texts to real Zipf's law-like rank distributions has not yet been established. Therefore, we suggest that Zipf's law might in fact be a fundamental law in natural languages. |
### Instruction:
Does adiponectin stimulate prostaglandin E ( 2 ) production in rheumatoid arthritis synovial fibroblasts?
### Response:
| Our findings indicate that adiponectin induces COX-2 and mPGES-1 expression, resulting in the enhancement of PGE(2) production by RASFs. Thus, adiponectin may play a role in the pathogenesis of synovitis in RA patients. |
### Instruction:
Does polo-like kinase-1 regulate first cleavage of one-cell embryos in culture during assisted reproduction?
### Response:
| The PLK1 plays a crucial role during the first cleavage of one-cell embryos, and the zygotes are unable to divide successfully without functional PLK1. |
### Instruction:
Is cisplatin-induced gastrointestinal dysmotility aggravated after chronic administration in the rat . Comparison with pica?
### Response:
| Whereas gastric dysmotility induced by cisplatin is parallel to the development of acute pica and might underlie facilitation of pica throughout chronic treatment, it does not explain its long-term maintenance. These findings should be taken into account in the search for new antiemetic strategies. |
### Instruction:
Does the fixation target influence the near deviation and AC/A ratio in intermittent exotropia?
### Response:
| Through careful control of accommodation by ensuring relaxation with plus lenses to clear N5 print, we revealed increases in the AC/A ratio and unmasked deviations that would otherwise have been considered to be characteristic of true divergence excess. Simulated and true deviations are possibly part of a continuum and clinical delineation may be influenced by testing artefact. |
### Instruction:
Is co-administration of the JAK inhibitor CP-690,550 and methotrexate well tolerated in patients with rheumatoid arthritis without need for dose adjustment?
### Response:
| Co-administration of CP-690,550 and MTX was safe and well tolerated. There was no clinically significant effect on the PK profile of either drug. Therefore, dose adjustments should not be required when co-administering CP-690,550 and MTX. |
### Instruction:
Are dietary patterns associated with lower incidence of type 2 diabetes in middle-aged women : the Shanghai Women 's Health Study?
### Response:
| We identified and characterized dietary patterns in middle-aged Chinese women by using cluster analysis. We identified a dietary pattern low in staple foods and high in dairy milk, which was associated with lower risk of T2D. Study of dietary patterns will help elucidate links between diet and disease, and contribute to the development of healthy eating guidelines for health promotion. |
### Instruction:
Does critical appraisal of : The endotracheal tube air leak test predict extubation outcome in critically ill pediatric patients . Pediatr Crit Care Med 2008 ; 9:490-496?
### Response:
| Pediatric patients who are otherwise candidates for extubation but do not have an endotracheal airleak may successfully be extubated. |
### Instruction:
Does transcriptomic analysis reveal differential gene expression in response to aluminium in common bean ( Phaseolus vulgaris ) genotypes?
### Response:
| The expression of a citrate transporter MATE gene is crucial for citrate exudation in common bean. However, although the expression of the citrate transporter is a prerequisite for citrate exudation, genotypic Al resistance in common bean particularly depends on the capacity to sustain the synthesis of citrate for maintaining the cytosolic citrate pool that enables exudation. |
### Instruction:
Does oral health care reduce the risk of postoperative surgical site infection in inpatients with oral squamous cell carcinoma?
### Response:
| Oral health care may reduce the risk of postoperative WI in patients with OSCC. |
### Instruction:
Does the combined ion channel blocker AZD1305 attenuate late Na current and IKr-induced action potential prolongation and repolarization instability?
### Response:
| By blocking INalate, AZD1305 attenuates excessive APD90 prolongation and repolarization instability following sudden slowing of rhythm implying a low proarrhythmic potential for AZD1305. |
### Instruction:
Do rHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones?
### Response:
| Herein, we demonstrate a critical role for RHOA and PRKCZ in the regulation of different aspects of cell motility of pancreatic adenocarcinoma and demonstrate the need to inhibit both pathways to obtain a functionally relevant effect in most assays. These results indicate that RHOA and PRKCZ, and their downstream effectors, can represent important pharmacological targets that could potentially control the highly metastatic attitude of PDAC. |
### Instruction:
Is mFSD2A a novel lung tumor suppressor gene modulating cell cycle and matrix attachment?
### Response:
| Together these data suggest that MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment. |
### Instruction:
Are health state preferences equivalent in the United States and Trinidad and Tobago?
### Response:
| Overall, we found the US and Trinidad and Tobago weights were highly similar and that the choice of either set of weights would lead to similar conclusions. |
### Instruction:
Do st. John 's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier?
### Response:
| Our findings provide new insights into the short-term interaction of SJW with P-glycoprotein at the blood-brain barrier. They are of potential relevance given the wide use of SJW as OTC medication and the importance P-glycoprotein has for CNS therapy. |
### Instruction:
Is lipid-lowering treatment related to decreased risk of dementia : a population-based study ( FINRISK )?
### Response:
| Preliminary results from the FINRISK study indicate that lipid-lowering drugs may have a beneficial effect in dementia prevention. Further data linkage is ongoing in order to investigate the roles of different types of lipid-lowering drugs. |
### Instruction:
Are dietary fat and bile juice , but not obesity , responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats?
### Response:
| Excessive dietary fat and/or increased levels of luminal bile juice, but not genetic obesity, are responsible for the increase in small intestinal permeability resulting from the suppression of TJ protein expression. |
### Instruction:
Is angiographic embolization safe and effective therapy for blunt abdominal solid organ injury in children?
### Response:
| : AE is a safe and an effective technique for controlling hemorrhage from blunt ASO injuries in select pediatric patients. |
### Instruction:
Are physician champions key to improving antibiotic prescribing quality?
### Response:
| An effective local leader to serve as a physician champion was key to the success of this project. Organizational factors modify the effectiveness of QI interventions targeting individual physician performance and should be addressed during program implementation. |
### Instruction:
Is routine TORCH screening warranted in neonates with subependymal cysts?
### Response:
| The co-occurrence of TORCH congenital infections in infants with SEC is rare. Routine TORCH screening in neonates with SEC does not seem warranted. |
### Instruction:
Does nonobese population in a developing country have a high prevalence of nonalcoholic fatty liver and significant liver disease?
### Response:
| There is a significant prevalence of NAFL and potentially significant liver disease, including cryptogenic cirrhosis, in this predominantly nonobese, nonaffluent population in a developing country. NAFL will be a major determinant of future liver disease burden in countries of the developing world. |
### Instruction:
Is induction of balance and breadth in the immune response beneficial for the control of SIVmac239 replication in rhesus monkeys?
### Response:
| Induction of balance and breadth in the immune response is beneficial in controlling SIVmac239 replication in rhesus monkeys. This study provides insight for the future development of an effective HIV vaccine. |
### Instruction:
Do synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis?
### Response:
| Despite the similar histologic appearance of inflamed joints in patients with different subtypes of JIA, there are differences in protein expression according to the subtype of JIA. Haptoglobin is differentially expressed between the subtypes of JIA and is locally produced in an inflamed joint in JIA. Haptoglobin and other differentially expressed proteins may be potential biomarkers in JIA. |
### Instruction:
Does cryoprobe biopsy increase the diagnostic yield in endobronchial tumor lesions?
### Response:
| Cryobiopsy is safe and increases the diagnostic yield in endobronchial tumor lesions. The method also is feasible under routine conditions. |
### Instruction:
Is cD40 ligand shedding regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha ( IIb ) beta ( 3 )?
### Response:
| The results presented here strongly suggest that MMP-2 interacts with alpha(IIb)beta(3) to regulate the shedding of CD40L exposed on the surfaces of activated human platelets. |
### Instruction:
Does chemokine CCL3 facilitate the migration of hepatoma cells by changing the concentration intracellular Ca?
### Response:
| Chemokine CCL3 facilitates the migration of hepatoma by changing the concentration intracellular Ca(2+). The CCL3-CCR1 axis may play an important role in HCC invasion and metastasis. It may also be a potential target for HCC therapy or for prevention of the recurrence and metastasis of HCC. |
### Instruction:
Does serum ferritin concentration predict mortality in patients awaiting liver transplantation?
### Response:
| Serum ferritin concentration is an independent predictor of mortality-related and liver-related clinical events. Baseline serum ferritin identifies a group of "higher-risk" patients awaiting OLT and should be investigated as an adjunct to MELD in organ allocation. |
### Instruction:
Does activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increase nitric oxide synthesis and microvascular perfusion?
### Response:
| Activation of AMPK by AICAR activates endothelial nitric oxide synthase in arteriolar endothelium by increasing its Ser1177 phosphorylation, which leads to vasodilation of resistance arteries and recruitment of microvascular perfusion in muscle. |
### Instruction:
Does soluble epoxide hydrolase deficiency attenuate neointima formation in the femoral cuff model of hyperlipidemic mice?
### Response:
| These observations suggest that inhibition of sEH prevents vascular remodeling in an inflammatory model but not in a blood flow-dependent model of neointima formation. |
### Instruction:
Does nationwide linkage analysis in Scotland implicate age as the critical overall determinant of mortality in ulcerative colitis?
### Response:
| Hospital admission in UC patients >65 is associated with high mortality. Management strategies should consider this by treatment in specialist units, early investigation, focused medical treatment and earlier surgical referral. |
### Instruction:
Does sequence of immunoglobulin isotype exposure modulate inflammatory response to bacteria and lipopolysaccharide in vitro?
### Response:
| The sequence of immunoglobulin isotype involvement in infectious processes is important in modulating the cytokine response to bacteria and LPS by inflammatory cells. Our in vitro results support the critical role of sIgA in the proximal airways in mitigating inflammatory responses by other humoral defenses in the distal airways. Loss of effective sIgA function may contribute to increased morbidity and deaths from nosocomial pneumonia in compromised patients. |
### Instruction:
Does toll-like receptor 2 play a critical role in cardiac dysfunction during polymicrobial sepsis?
### Response:
| These studies suggest that toll-like receptor 2 signaling plays a critical role in mediating cardiomyopathy, deleterious myocardial and systemic inflammation, and high mortality during polymicrobial sepsis. |
### Instruction:
Does fibroblast growth factor receptor 3-IIIc mediate colorectal cancer growth and migration?
### Response:
| Our data show that FGFR3-IIIc exerts oncogenic functions by mediating FGF18 effects in colorectal cancer and may constitute a promising new target for therapeutic interventions. |
### Instruction:
Does flexible modeling improve assessment of prognostic value of C-reactive protein in advanced non-small cell lung cancer?
### Response:
| Our analysis shows that flexible modeling provides new insights regarding the value of CRP as a prognostic factor in NSCLC and that Cox's PH model underestimates early risks associated with high CRP. |
### Instruction:
Are impaired mobility , ASA status and administration of tramadol risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery?
### Response:
| PD is a frequent and severe postoperative event in elderly patients after major abdominal surgery. A perioperative geriatric assessment should be recommended to patients with an American Society of Anesthesiologists status of 3-4 and preoperative impaired mobility to facilitate the management of PD. In these patients, the postoperative administration of tramadol should be avoided. |
### Instruction:
Does a novel link between Sus1 and the cytoplasmic mRNA decay machinery suggest a broad role in mRNA metabolism?
### Response:
| In this study, we found genetic and biochemical association between Sus1 and components responsible for cytoplasmic mRNA metabolism. Moreover, Sus1 accumulates in discrete cytoplasmic granules, which partially co-localise with P-bodies and stress granules under specific conditions. These interactions suggest a role for Sus1 in gene expression during cytoplasmic mRNA metabolism in addition to its nuclear function. |
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