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### Instruction:
Does comparative profiling of primary colorectal carcinomas and liver metastases identify LEF1 as a prognostic biomarker?
### Response:
| Among genes differentially expressed between CLM and primary CRC, we demonstrate overexpression of LEF1 in primary CRC to be a prognostic factor for poor survival and increased risk for liver metastasis. |
### Instruction:
Does methylation profiling of rectal cancer identify novel markers of early-stage disease?
### Response:
| Locus-specific hypermethylation was more prevalent in early- than late-stage disease. Hypermethylation of two or more of a panel of five tumour suppressor genes was associated with localized disease. |
### Instruction:
Do alternative TFAP2A isoforms have distinct activities in breast cancer?
### Response:
| Our findings suggest that TFAP2A isoforms may be differentially regulated during breast tumourigenesis and this, coupled with differences in their transcriptional activity, may impact on tumour responses to tamoxifen therapy. These data also have implications for the interpretation of tumour studies that seek to correlate outcomes with TFAP2A expression level. |
### Instruction:
Does glyphosate reduce urediniospore development and Puccinia psidii disease severity on Eucalyptus grandis?
### Response:
| Reductions in germination and apressorium formation of P. psidii urediniospores with increasing glyphosate dose indicate that a lower severity and intensity of the disease may perhaps be due to blockage of the shikimic acid pathway in the fungal metabolic system. |
### Instruction:
Does treatment with the immunomodulator FTY720 promote spontaneous bacterial infections after experimental stroke in mice?
### Response:
| Our results corroborate the experimental evidence of the protective effect of FTY720 seen in different rodent stroke models. Interestingly, we found no increase in bacterial lung infections even though FTY720 strongly reduces the number of circulating leukocytes. |
### Instruction:
Are temporomandibular disorders differentially associated with headache diagnoses : a controlled study?
### Response:
| TMD, TMD subtypes, and TMD severity are independently associated with specific headache syndromes and with headache frequency. This differential association suggests that the presence of central facilitation of nociceptive inputs may be of importance, as positive association was observed only when muscular TMD pain was involved. |
### Instruction:
Does timing of lower extremity frontal plane motion differ between female and male athletes during a landing task?
### Response:
| Frontal plane kinematic temporal relationships at the hip, knee, and ankle differ between genders. The components of dynamic knee valgus peak during the deceleration phase in women and during the acceleration phase in men during a drop-jump landing. These data suggest that men and women employ a completely different kinematic landing/jumping strategy and that women land and collapse very rapidly into valgus compared with their male counterparts. |
### Instruction:
Does low serum citrulline concentration correlate with catheter-related bloodstream infections in children with intestinal failure?
### Response:
| Low serum citrulline concentration and longer central venous catheter time are independently associated with CRBSI in children with intestinal failure. Serum citrulline concentration may be a useful biomarker to identify patients with intestinal failure who are at high risk of developing a CRBSI. |
### Instruction:
Is restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy calprotectin-dependent?
### Response:
| Reconstituted NET formation by GT for human CGD was associated with rapid cure of pre-existing therapy-refractory invasive pulmonary aspergillosis in vivo, underlining the role of functional NADPH oxidase in NET formation and calprotectin release for antifungal activity. These results demonstrate the critical role of calprotectin in human innate immune defense against Aspergillus infection. |
### Instruction:
Do lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension?
### Response:
| Using microarray analysis on carefully phenotyped SSc and comparator lung tissues, we demonstrated distinct molecular profiles in tissues and fibroblasts from patients with SSc-associated lung disease compared to idiopathic forms of lung disease. Unique molecular signatures were generated that are disease specific (SSc) and phenotype specific (PF versus PAH). These signatures provide new insights into the pathogenesis and potential therapeutic targets of SSc-related lung disease. |
### Instruction:
Does a systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveal an association with IL2/IL21?
### Response:
| The findings, although requiring replication, suggest that IL2/IL21 may play a key role in the pathogenesis of psoriasis as well as in other diverse autoimmune diseases. |
### Instruction:
Are autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer associated with a better prognosis?
### Response:
| Autoantibodies to specific cancer associated glycoforms of MUC1 are found more frequently and at higher levels in early stage breast cancer patients than in women with benign breast disease or healthy women. Association of strong antibody response with reduced rate and delay in metastases suggests that autoantibodies can affect disease progression. |
### Instruction:
Are vascular procedures in nonagenarians and centenarians safe?
### Response:
| Patients in their 90s can safely undergo vascular procedures with reasonable early outcomes. Most patients return to their preoperative status. Age alone should not be a determinant in refusing surgery in this age group. |
### Instruction:
Does vascular endothelial growth factor-B gene transfer exacerbate retinal and choroidal neovascularization and vasopermeability without promoting inflammation?
### Response:
| VEGF-B overexpression promoted pathological retinal and choroidal NV and BRB breakdown without causing inflammation, which is associated with the progression of diabetic retinopathy and age-related macular degeneration, showing that these complications are not dependent on inflammation. VEGF-B targeting could benefit antiangiogenic therapy. |
### Instruction:
Does a novel p.E276K IDUA mutation decreasing α-L-iduronidase activity cause mucopolysaccharidosis type I?
### Response:
| This study reports a novel mutation, expanding the mutational spectrum for MPS I. |
### Instruction:
Is regeneration of the exocrine pancreas delayed in telomere-dysfunctional mice?
### Response:
| Our results indicate that pancreatic regeneration is limited in the context of telomere dysfunction without evidence for p53 checkpoint activation. |
### Instruction:
Are metabolic cycles linked to the cardiovascular diurnal rhythm in rats with essential hypertension?
### Response:
| These results indicate that the metabolic cycle is an important determinant of the cardiovascular diurnal rhythm and that disrupted BP rhythms in hypertensive patients can be normalized by manipulating feeding cycles. |
### Instruction:
Do bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis?
### Response:
| Bile proteomic analysis discriminates benign conditions from CC accurately. This method may become a diagnostic tool in future as it offers a new possibility to diagnose malignant bile duct disease and thus enables efficient therapy particularly in patients with PSC. |
### Instruction:
Do hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice?
### Response:
| Cotransplantation with in vitro generated MDSC can effectively protect islet allografts from host immune attack. Local delivery of potent immune suppressor cells for cell transplants holds great clinical application potential. |
### Instruction:
Does prevalence and correlate of bipolar spectrum disorder in the world mental health survey initiative?
### Response:
| Despite cross-site variation in the prevalence rates of BPS, the severity, impact, and patterns of comorbidity were remarkably similar internationally. The uniform increases in clinical correlates, suicidal behavior, and comorbidity across each diagnostic category provide evidence for the validity of the concept of BPS. Treatment needs for BPS are often unmet, particularly in low-income countries. |
### Instruction:
Do modifications of the ABCD2 score improve the risk stratification of transient ischemic attack patients?
### Response:
| Modifications of the ABCD2 score changed the risk category for few patients and did not improve the overall predictive value of the score. |
### Instruction:
Does pulsatile pulmonary perfusion with oxygenated blood ameliorate pulmonary hemodynamic and respiratory indices in low-risk coronary artery bypass patients?
### Response:
| Oxygenated blood PPP proved safe and significantly ameliorated pulmonary hemodynamic parameters and respiratory indices in low-risk CABG. |
### Instruction:
Does intra-arterial injection of human embryonic stem cells in athymic rat hind limb ischemia model lead to arteriogenesis?
### Response:
| Intra-arterial injection of hESC resulted in moderate improvement of flow and perfusion and increased number of arteries in the ischemic hind limb. No consistent change in perfusion, flow, and number of arteries was observed after intramuscular injection. |
### Instruction:
Does dexamethasone protect airway epithelial cell line NCI-H292 against lipopolysaccharide induced endoplasmic reticulum stress and apoptosis?
### Response:
| LPS may activate ER stress through the overexpression of MUC5AC. Dexamethasone may protect human airway epithelial cells against ER stress-related apoptosis by attenuating the overload of MUC5AC. |
### Instruction:
Is l1 Cell adhesion molecule ( L1CAM ) expression at the cancer invasive front a novel prognostic marker of pancreatic ductal adenocarcinoma?
### Response:
| L1CAM could play an important role in the invasive process in vivo, and is thought to be a good indicator of prognosis in PDAC. |
### Instruction:
Does a comprehensive obstetrics patient safety program improve safety climate and culture?
### Response:
| Safety programs can improve workforce perceptions of safety and an improved safety climate. |
### Instruction:
Is chronic maternal depression associated with reduced weight gain in latino infants from birth to 2 years of age?
### Response:
| Exposure to chronic maternal depression in the pre- and postnatal period was associated with reduced weight gain in the first two years of life and greater risk for failure to thrive, in comparison with unexposed infants or those exposed episodically. The infants of mothers with chronic depression may need additional nutritional monitoring and intervention. |
### Instruction:
Does lactobacillus rhamnosus HN001 attenuate allergy development in a pig model?
### Response:
| Probiotic supplementation decreased the severity of allergic skin and lung responses in allergen-sensitized pigs with a corresponding increase in IFN-γ expression. A similar correlation between certain allergic responses and increased IFN-γ expression has been reported in human clinical studies of allergy; this pig model of allergy may be indicative of potential probiotic modulation of allergic lung disease in humans. |
### Instruction:
Do green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats?
### Response:
| GTP attenuates myocardial fibrosis through a suppression of chronic inflammation and innate immune responses. |
### Instruction:
Does quantitative determination of superoxide in plant leave using a modified NBT staining method?
### Response:
| Chloroform allowed a selective formazan extraction and removal of potential endogenous, exogenous or procedural artefacts that may interfere with the quantitative determination. This protocol can be used to quantify the superoxide produced in plant tissues using any traditional qualitative NBT histochemical staining method. |
### Instruction:
Is bcl-2 upregulation induced by miR-21 via a direct interaction associated with apoptosis and chemoresistance in MIA PaCa-2 pancreatic cancer cells?
### Response:
| Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis, chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells. |
### Instruction:
Do s100B transgenic mice develop features of Parkinson 's disease?
### Response:
| Overexpression of S100B in the brain resulted in motor coordination impairment, which may have resulted from the downregulation of D2DR and GRK2 expressions, increased DA synthesis and metabolism, and decreased 5-HT level. Therefore, S100B may be a potential cause of pathogenesis in PD. |
### Instruction:
Does amlodipine treatment prevent angiotensin II-induced human umbilical vein endothelial cell apoptosis?
### Response:
| Our data demonstrate that amlodipine ameliorates Ang II-induced endothelial apoptosis, which is likely associated with the elevation of Bcl-2/Bax ratio and reduction of the LOX-1 expression. |
### Instruction:
Is iFN-stimulated gene expression a useful potential molecular marker of response to antiviral treatment with Peg-IFNα 2b and ribavirin in patients with hepatitis C virus genotype 1?
### Response:
| IFI27, IFIT1, IFI6, ISG15, and CXCL10 genes are potential biological markers useful for predicting response to Peg-IFNα 2b/RBV therapy in HCV-1 patients. |
### Instruction:
Is inguinal hernia repair in patients with cirrhosis associated with increased risk of complications and recurrence?
### Response:
| Our results indicate that the incidence of postoperative complications and long-term recurrence after inguinal hernia repair in LC patients does not differ from that in non-LC patients. Elective repair of symptomatic inguinal hernia in patients with cirrhosis should be advocated. |
### Instruction:
Does reduced vital capacity lead to exercise intolerance in patients with ankylosing spondylitis?
### Response:
| Rather than musculoskeletal manifestations, exercise intolerance was mainly explained by pulmonary function impairment in AS patients. |
### Instruction:
Does oocyte-targeted deletion reveal that hsp90b1 is needed for the completion of first mitosis in mouse zygotes?
### Response:
| Our findings demonstrate that the maternal contribution of Hsp90b1 is critical for the development of murine zygotes. All together our data indicate that Hsp90b1 is involved in unique and specific aspects of the first mitosis, which brings together the maternal and paternal genomes on a single spindle. |
### Instruction:
Do ω-3 fatty acids attenuate mucosal inflammation in premature rat pups?
### Response:
| Our findings indicate that ω-3 fatty acids are beneficial for protecting the premature intestine from inflammation by regulating eicosanoid- and nuclear factor-κB-related metabolite expression. |
### Instruction:
Is phosphorylation-dependent 14-3-3 binding to LRRK2 impaired by common mutations of familial Parkinson 's disease?
### Response:
| LRRK2 is extensively phosphorylated in vivo, and the phosphorylation of specific sites (e.g. S935) determines 14-3-3 binding of LRRK2. We propose that 14-3-3 is an important regulator of LRRK2-mediated cellular functions. Our study suggests that PKA, a cAMP-dependent kinase involved in regulating dopamine physiology, is a potential upstream kinase that phosphorylates LRRK2 at S935. Furthermore, the reduction of phosphorylation/14-3-3 binding of LRRK2 due to the common familial PD-related mutations provides novel insight into the pathogenic mechanism of LRRK2-linked PD. |
### Instruction:
Is the large zinc finger protein ZAS3 a critical modulator of osteoclastogenesis?
### Response:
| Collectively, the data suggested a novel role of ZAS3 as a positive regulator of osteoclast differentiation. ZAS3 deficiency caused increased bone mass, at least in part due to decreased osteoclast formation and bone resorption. These functions of ZAS3 were mediated via activation of multiple intracellular targets. In the cytoplasmic compartment, ZAS3 associated with TRAF6 to control NF-kB and MAP kinase signaling cascades. Nuclear ZAS3 acted as a transcriptional regulator for osteoclast-associated genes. Additionally, ZAS3 activated NFATc1 required for the integration of RANK signaling in the terminal differentiation of osteoclasts. Thus, ZAS3 was a crucial molecule in osteoclast differentiation, which might potentially serve as a target in the design of therapeutic interventions for the treatment of bone diseases related to increased osteoclast activity such as postmenopausal osteoporosis, Paget's disease, and rheumatoid arthritis. |
### Instruction:
Does preoperative left ventricular dysfunction predispose to postoperative acute kidney injury and long-term mortality?
### Response:
| Patients with preoperatively LVD have an increased risk of developing AKI after vascular surgery. The occurrence of AKI in patients with LVD has an incremental predictive value toward cardiovascular mortality risk during long-term follow-up. |
### Instruction:
Do clinical features of asthma in children differ with regard to the intensity of distal gastroesophageal acid reflux?
### Response:
| There are differences in clinical features of asthma in children with regard to the intensity of esophageal acid exposure. Symptoms of asthma in nonatopic individuals with early onset and difficult-to-control nighttime asthma attacks suggest the possibility of concomitant, clinically relevant GER. |
### Instruction:
Does e. coli Nissle 1917 affect Salmonella adhesion to porcine intestinal epithelial cells?
### Response:
| We propose that EcN affects Salmonella adhesion through secretory components. This mechanism appears to be common to many E. coli strains, with strong adherence being a prerequisite for an effective reduction of SiiE-mediated Salmonella adhesion. |
### Instruction:
Is cR1 associated with amyloid plaque burden and age-related cognitive decline?
### Response:
| We found that common variation at the CR1 locus has a broad impact on cognition and that this effect is largely mediated by an individual's amyloid plaque burden. We therefore highlight 1 functional consequence of the CR1 susceptibility allele and generalize the role of this locus to cognitive aging in the general population. |
### Instruction:
Is downregulation of stathmin involved in malignant phenotype reversion and cell apoptosis in esophageal squamous cell carcinoma?
### Response:
| These findings demonstrate that stathmin may play an essential role in carcinogenesis of ESCC, which will lay a foundation for target therapy of ESCC. |
### Instruction:
Is oncostatin M expressed in atherosclerotic lesions : a role for Oncostatin M in the pathogenesis of atherosclerosis?
### Response:
| These findings demonstrate that OSM is expressed in atherosclerotic lesions and may contribute to the progression of atherosclerosis by promoting SMC proliferation, migration and extracellular matrix protein synthesis through the STAT pathway. |
### Instruction:
Is blood pressure and not uraemia the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity?
### Response:
| These findings suggest that declining renal function, in the absence of significant co-morbidity, is associated with progressive arterial stiffness, but only patients close to dialysis exhibit endothelial dysfunction. Whilst blood pressure remains the major determinant of PWV and FMD, inflammation, oxidative stress and endothelin-nitric oxide balance contribute to cardiovascular risk, in this non-comorbid cohort. |
### Instruction:
Is brain cortical activity influenced by exercise mode and intensity?
### Response:
| In conclusion, these findings demonstrate that cortical activation patterns depend on exercise mode and intensity and that individual exercise preferences may contribute to the positive psychophysiological response. |
### Instruction:
Is supraspinal fatigue similar in men and women for a low-force fatiguing contraction?
### Response:
| Supraspinal fatigue was similar for men and women after the low-force fatiguing contraction, and the sex difference in muscle fatigue was associated with peripheral mechanisms. Furthermore, supraspinal fatigue can be quantified in both men and women without influencing motor performance. |
### Instruction:
Are expression of microRNA and their gene targets dysregulated in preinvasive breast cancer?
### Response:
| These data provide the first miRNA expression profile of normal breast epithelium and of preinvasive breast carcinoma. Further, we demonstrate that altered miRNA expression can modulate gene expression changes that characterize these early cancers. We conclude that miRNA dysregulation likely plays a substantial role in early breast cancer development. |
### Instruction:
Is the Peroxisomal Targeting Signal 1 in sterol carrier protein 2 autonomous and essential for receptor recognition?
### Response:
| Our data therefore suggest that at least in the case of sterol carrier protein 2 the contribution of the second binding site is not essential for peroxisomal import. At this stage, however, we cannot rule out that other cargo proteins may require this ancillary binding site. |
### Instruction:
Is high-sensitivity C-reactive protein independently associated with arterial stiffness in women with metabolic syndrome?
### Response:
| Levels of hs-CRP may provide important prognostic information in terms of future cardiovascular risk in women with MetS. |
### Instruction:
Do environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs?
### Response:
| Exposure of neonates to EPFR-containing CGUFP induced pulmonary oxidative stress and lung dysfunction. This correlated with alterations in the expression of various proteins associated with the response to oxidative stress and the regulation of glucocorticoid receptor translocation in T lymphocytes. |
### Instruction:
Does surgical approach to intramedullary cavernous malformations of the spinal cord?
### Response:
| Intramedullary spinal cord cavernous malformations are complex entities, and it is our hope that this article will improve readers' understanding of their clinical characteristics, their indications for treatment, and the surgical pathways through which these lesions can be safely resected. |
### Instruction:
Does male gender significantly increase risk of oxidative stress related congenital anomalies in the non-diabetic population?
### Response:
| In non-diabetic pregnancies, male gender appears to be an independent risk factor for some types of CA believed to be associated with OS. Cigarette smoking, a well recognized source of OS only increased the risk of CL/P in males. |
### Instruction:
Do noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C?
### Response:
| Noninvasive tests for liver fibrosis (measurement of liver stiffness or FibroTest) can predict 5-year survival of patients with chronic hepatitis C. These tools might help physicians determine prognosis at earlier stages and discuss specific treatments, such as liver transplantation. |
### Instruction:
Do human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells?
### Response:
| CMFs suppress the immune response in normal colon tissue and might therefore help maintain colonic mucosal tolerance. Alterations in CMF-mediated induction of Treg cells might promote pathogenesis of inflammatory bowel diseases. |
### Instruction:
Do four cardiac hormones cause death of human cancer cells but not of healthy cells?
### Response:
| Four cardiac hormones cause death of pancreatic and prostate cancer cells but not of normal prostate, lung, or kidney cells. |
### Instruction:
Does conversion from conventional in-centre thrice-weekly haemodialysis to short daily home haemodialysis ameliorate uremia-associated clinical parameters?
### Response:
| Conversion from conventional in-centre to short daily home HD leads to an improvement in numerous dialysis-associated metabolic variables and thus represents an attractive treatment modality for selected patients. |
### Instruction:
Do retrospective cohort study of the predictors of implant failure in the posterior maxilla?
### Response:
| Within the limitations of this retrospective study, the results suggest that there are risk factors associated with maxillary posterior implant failure. Implants placed in areas with inadequate residual crestal bone height that required sinus augmentation were statistically associated with implant failure. |
### Instruction:
Are individual fascicles of the paraspinal muscles activated by discrete cortical networks in humans?
### Response:
| Different fascicles of the paraspinal muscles are organised and thus could be controlled by discrete neuronal networks within the motor cortex. Further, TMS mapping from surface recordings of paraspinal muscles may be confounded by cross-talk from multiple underlying fascicles. |
### Instruction:
Do alternate transcripts of a floral developmental regulator have both distinct and redundant functions in opium poppy?
### Response:
| These results describe the first explicit functional analysis of an AG-clade gene in a basal eudicot; illustrate one of the few examples of the functional consequences of alternative splicing in transcription factors and reveal the importance of alternative transcription, as well as gene duplication, as a driving force in evolution. |
### Instruction:
Are interleukin-2 serum levels elevated in patients with uremic pruritus : a novel finding with practical implications?
### Response:
| The results of our study, for the first time, point to the potential important role of IL-2 in UP and further support the notion of TH1 overactivity in its pathogenesis. Our study paves the way for further studies focusing on the contribution of IL-2 to the UP, such as the experimental use of anti-IL-2 receptor antibodies. |
### Instruction:
Are serum selenium levels inversely associated with death risk among hemodialysis patients?
### Response:
| Serum selenium levels were inversely associated with death risk, especially death risk due to infectious disease, among hemodialysis patients. Decreased serum selenium level may contribute to immunity dysfunction and may increase the risk of death from infectious disease in hemodialysis patients. |
### Instruction:
Do human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production?
### Response:
| The present results indicate that human MSCs constitutively produce OPG, resulting in inhibition of osteoclastogenesis and expression of NF-ATc1 and cathepsin K in the absence of cell-cell contact. Therefore, we conclude that human MSCs exert a suppressive effect on osteoclastogenesis, which may be beneficial in inhibition of joint damage in RA. |
### Instruction:
Is polymorphisms of GSTP1 associated with differences of chemotherapy response and toxicity in breast cancer?
### Response:
| GSTP1 polymorphism was associated with the chemotherapy response or adverse effects of EPI and CTX regimens. |
### Instruction:
Does cyanidin-3-O-β-glucoside improve obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity?
### Response:
| Our present data thus demonstrate that Cy-3-g improves obesity and triglyceride metabolism in KK-Ay mice. The underlying mechanism is found to be partly related to the activation of LPL in plasma and skeletal muscle, and inhibition of LPL in adipose tissue following the activation of pAMPK. |
### Instruction:
Does interferon-γ modulate intestinal epithelial cell function in-vitro through a TGFβ-dependent mechanism?
### Response:
| These studies suggest that IFNγ produced by constituents of the mucosal immune system modulates epithelial cell functions with relevance for intestinal wound healing and may play a role in preserving the integrity of the intestinal epithelium following various forms of injuries. |
### Instruction:
Is monthly screening for BK viremia an effective strategy to prevent BK virus nephropathy in renal transplant recipients?
### Response:
| BKV infection is an early complication. Monthly NAT in blood during the first 6 months and immediate reduction of IS in viremic patients almost completely prevent definitive BKVN. |
### Instruction:
Does rectal administration of lipopolysaccharide and ovalbumin ameliorate acute murine colitis?
### Response:
| Rectal administration of LPS attenuated acute murine colitis, possibly through TLR4 down-regulation, and combined treatment of OVA additionally ameliorated colonic inflammation associated with up-regulation of IL-10. |
### Instruction:
Do intraoperative patellar kinematics following resection of the central one-third of the patellar tendon in the ovine stifle joint?
### Response:
| The data obtained in this study suggests that both the patellar height and integrity of the PT are important determinants of patellar kinematics in the ovine stifle joint. |
### Instruction:
Does a signature of aberrant immune responsiveness identify myocardial dysfunction in rheumatoid arthritis?
### Response:
| The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced myocardial dysfunction in patients with RA. The unique information added by the immune response score concerning the likelihood of LVDD warrants future longitudinal studies of its value in predicting future deterioration in myocardial function. |
### Instruction:
Does antimicrobial activity of the constituents of Smallanthus sonchifolius leave against methicillin-resistant Staphylococcus aureus?
### Response:
| These results suggest that only enhydrin can be considered as an antibacterial drug against MRSA. |
### Instruction:
Does cumulus cell gene expression predict better cleavage-stage embryo or blastocyst development and pregnancy for ICSI patients?
### Response:
| Multivariable models based on CC gene expression can be used to predict embryo development and pregnancy. |
### Instruction:
Is local peritoneal irrigation with intestinal alkaline phosphatase protective against peritonitis in mice?
### Response:
| Peritoneal irrigation with cIAP significantly enhances survival in a mouse model of peritonitis, likely through reduction of local inflammation and remote organ damage. We suggest that intraperitoneal cIAP irrigation could be a novel therapy for intra-abdominal sepsis. |
### Instruction:
Does uncertainty in nuchal translucency reference range at 11-14 weeks of gestation -- comparison to Swedish centiles?
### Response:
| Our results demonstrate that there are substantial differences in the NT medians and centiles between countries. |
### Instruction:
Do influence of the insertion time and number of polyps on miss rate in colonoscopy?
### Response:
| In usual clinical practice, colon polyps were frequently missed on colonoscopy. Comprehensive analysis of patient should be required to reduce the miss rates. |
### Instruction:
Is hbA1c related with uremic pruritus in diabetic and nondiabetic hemodialysis patients?
### Response:
| In both diabetic and nondiabetic patients, HbA1c is closely related with pruritus in HD patients. |
### Instruction:
Does fascia iliaca compartment block reduce emergence agitation by providing effective analgesic properties in children?
### Response:
| In children having surgery on the thigh, FICB effectively reduced the severity of emergence agitation and postoperative pain during the immediate postoperative period. |
### Instruction:
Does a recombinant human neuregulin-1 peptide improve preservation of the rodent heart after prolonged hypothermic storage?
### Response:
| rhNRG-1 given together with other activators of prosurvival pathways improves preservation of the rat heart and shows promise for increasing the cold-ischemic life of donor hearts in transplantation. |
### Instruction:
Does impact on mortality and cancer incidence rates of using random invitation from population register for recruitment to trials?
### Response:
| Recruitment to screening trials through invitation from population registers does not prevent a pronounced HVE on mortality. The impact on cancer incidence is much smaller. Similar shortfalls can be expected in other screening RCTs and it maybe prudent to use the various mortality and incidence rates presented as guides for calculating event rates and power in RCTs involving women. |
### Instruction:
Are biliary metal stents superior to plastic stents for preoperative biliary decompression in pancreatic cancer?
### Response:
| SEMS are superior to plastic stents for preoperative biliary decompression in pancreatic cancer. |
### Instruction:
Does candesartan with pioglitazone protect against endothelial dysfunction and inflammatory responses in porcine coronary arteries implanted with sirolimus-eluting stents?
### Response:
| Candesartan protected against vascular inflammation and restored endothelial function after SES implantation. The combination of candesartan and pioglitazone was more effective than candesartan monotherapy and might confer vascular protection when administered before SES implantation. |
### Instruction:
Does cyclin-dependent kinase 5 promote pancreatic β-cell survival via Fak-Akt signaling pathways?
### Response:
| This study shows that by regulating Fak phosphorylation and subsequently PI3K/Akt survival pathway, CDK5 plays a previously unrecognized role in promoting β-cell survival. |
### Instruction:
Does partial inhibition of insulin secretion result in glucose intolerance but not hyperglucagonemia?
### Response:
| Partial inhibition of insulin secretion results in impairment of glucose tolerance after a mixed meal and after glimepiride administration in the absence of a difference in glucagon secretion. They underscore the primary glucoregulatory role of insulin and support the evidence that β-cell secretion is not the only regulator of α-cell glucagon secretion. |
### Instruction:
Do behavioral healthcare services use in health savings accounts versus traditional health plans?
### Response:
| Our results suggest enrollment in CDHPs moderately affects the use of behavioral health services but do not affect the intensity of outpatient behavioral health services conditioned on initiating these services. These finding are somewhat limited in that specific information about benefits were not included in the study. These results are also subject to self-selection bias. Members who switched to CDHP may be influenced to do so by other unknown factors that bear on their behavioral health. |
### Instruction:
Does concurrent sulforaphane and eugenol induce differential effects on human cervical cancer cells?
### Response:
| This study clearly indicates that 2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention. |
### Instruction:
Does polysaccharide of Cordyceps sinensis enhance cisplatin cytotoxicity in non-small cell lung cancer H157 cell line?
### Response:
| The current study indicates that the polysaccharide of CS inhibits tumor growth in NSCLC and that CS may be a potential adjuvant chemotherapeutic agent in NSCLC therapy. |
### Instruction:
Does topiramate modulate hippocampus NMDA receptors via brain Ca ( 2+ ) homeostasis in pentylentetrazol-induced epilepsy of rats?
### Response:
| The two doses of TOP modulated MMCA activity, total brain cortex calcium and hippocampus NMDAR 2A and 2B subunit concentrations in the epileptic rats. |
### Instruction:
Is a lower antral follicle count associated with infertility?
### Response:
| Decreased AFC in infertile women suggests that factors affecting the size of the remaining follicle pool in younger women also affect oocyte quality and the likelihood of conception. |
### Instruction:
Are patient-reported outcomes superior in patients with Type 2 diabetes treated with liraglutide as compared with exenatide , when added to metformin , sulphonylurea or both : results from a randomized , open-label study?
### Response:
| These results demonstrate significant improvements in patients' treatment satisfaction with liraglutide compared with exenatide. |
### Instruction:
Is cardiovascular autonomic dysfunction associated with central obesity in persons with impaired glucose tolerance?
### Response:
| Cardiovascular autonomic neuropathy is common in persons with impaired glucose tolerance. Obesity, especially among men, seems to play an important role in the early pathogenesis of cardiovascular autonomic neuropathy. |
### Instruction:
Is pINCH1 transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression?
### Response:
| These results indicate that PINCH1 can shuttle into the nucleus from cytoplasm in podocytes, wherein it interacts with WT1 and suppresses podocyte-specific gene expression. Our studies reveal a previously unrecognized, novel function of PINCH1, in which it acts as a transcriptional regulator through controlling specific gene expression. |
### Instruction:
Does a comparison of methods for forecasting emergency department visits for respiratory illness using telehealth Ontario call?
### Response:
| Telehealth can be used to estimate ED visits for respiratory illness at the health unit level. Non-linear modeling methods produced better estimates than regression in larger health units. |
### Instruction:
Do immediate newborn care practices delay thermoregulation and breastfeeding initiation?
### Response:
| This minute-by-minute observational assessment revealed that performance and timing of immediate newborn care interventions are below WHO standards and deprive newborns of basic protections against infection and death. |
### Instruction:
Is coffee consumption associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C?
### Response:
| High-level consumption of coffee (more than 3 cups per day) is an independent predictor of improved virologic response to peginterferon plus ribavirin in patients with hepatitis C. |
### Instruction:
Is recurrence-free survival in prostate cancer related to increased stromal TRAIL expression?
### Response:
| Expression of the components of the pro-apoptotic TRAIL pathway is altered in prostate cancer. Moreover, TRAIL expression in the tumor microenvironment may affect recurrence-free survival rate of prostate cancer patients. Consequently, these results may be useful in devising future therapeutic strategies targeting the TRAIL pathway in prostate cancer. |
### Instruction:
Does timing of administration of bevacizumab chemotherapy affect wound healing after chest wall port placement?
### Response:
| The risk of a wound dehiscence requiring chest wall port explant in patients treated with bevacizumab was inversely proportional to the interval between bevacizumab administration and port placement, with significantly higher risk seen when the interval is less than 14 days. |
### Instruction:
Is reduced immunogenicity of influenza vaccines in HIV-infected compared with uninfected pregnant women associated with regulatory T cells?
### Response:
| Influenza vaccines have reduced immunogenicity in HIV-infected compared with uninfected pregnant women. In HIV-infected women, increased regulatory CD4(+)FoxP3(+)% may attenuate the immunogenicity of vaccines. |
### Instruction:
Does simvastatin improve learning and memory in control but not in olfactory bulbectomized rats?
### Response:
| In the present study, simvastatin treatment enhanced cognition in intact rats, but had no effect in OBX rats. These results are in line with the idea that statins may attenuate (early) age-associated cognitive decline in humans. |
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