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### Instruction:
Does genetic variation in MMP20 contribute to higher caries experience?
### Response:
| Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits. |
### Instruction:
Do [ Dental implant restoration in 248 patients with periodontal disease and type 2 diabetes ]?
### Response:
| The patients with periodontal disease and type 2 diabetes are suitable for implant treatment with satisfactory results under the conditions that the indication and risk factors are evaluated and controlled strictly. |
### Instruction:
Do fenoterol enantiomers possess beneficial therapeutic properties of their racemic mixture in the rat model of post myocardial infarction dilated cardiomyopathy?
### Response:
| The conclusion drawn on the basis of previous experiments with single cardiomyocytes that RR-enantiomer of fenoterol represents an active component of racemic fenoterol and can be further investigated as a new drug for treatment of chronic heart failure was not confirmed in the whole animal model of DCM. |
### Instruction:
Is cIP2A a predictor of poor prognosis in colon cancer?
### Response:
| CIP2A is a prognostic factor in colon cancer. The knockdown of CIP2A reduced proliferation and anchorage-independent colony formation and increased 5-fluorouracil, oxaliplatin, and SN38 efficacy in colon cancer cell lines. |
### Instruction:
Is the neuropeptide galanin a novel inhibitor of human hair growth?
### Response:
| We present the first evidence that human HFs are both a source and a functionally relevant target of galanin. Due to its hair growth-inhibitory properties in vitro, galanin application deserves further exploration as a potential new treatment strategy for unwanted hair growth (hirsutism, hypertrichosis). |
### Instruction:
Do helical EndoStaples enhance endograft fixation in an experimental model using human cadaveric aortas?
### Response:
| The fixation of eight different endografts was increased by a mean of 30 N with four Aptus EndoStaples and by a mean of 57 N with six EndoStaples in this model. Endostaples can increase endograft fixation to levels equivalent or superior to that of a hand-sewn anastomosis. The application of six EndoStaples results in aortic tissue failure above the fixation zone, demonstrating fixation strength that exceeds inherent aortic integrity in these cadavers. |
### Instruction:
Does [ Gemin3 inhibit cell apoptosis through suppression of p53 expression ]?
### Response:
| Gemin3 binds with p53 forming a complex and plays an anti-apoptotic role by repressing the p53 expression. |
### Instruction:
Do single unit attachments improve peri-implant soft tissue conditions in mandibular overdentures supported by four implants?
### Response:
| Although the patients' satisfaction was similar in both groups the Locator(®) system demonstrated better soft tissues scores because hygienic maintenance was more complicated around bars. This may increase the frequency of chronic inflammations around the implants. |
### Instruction:
Is cubilin expressed in rat and human glomerular podocytes?
### Response:
| Our findings show that the podocytes display the two endocytic receptors which are responsible for the only documented process for protein reabsorption in proximal tubule cells. |
### Instruction:
Are sleep problems associated with binge eating in women?
### Response:
| This investigation offers empirical support for an independent association between sleep problems and BE, which is likely due to complex psychological, biological, neuroendocrine, and metabolic factors. |
### Instruction:
Does src tyrosine kinase inhibition prevent pulmonary ischemia-reperfusion-induced acute lung injury?
### Response:
| During pulmonary ischemia, Src PTK activation, rather than alteration in gene expression, may play a critical role in reperfusion-induced lung injury. Src PTK inhibition presents a new prophylactic treatment for pulmonary ischemia-reperfusion-induced acute lung injury. |
### Instruction:
Do relative effects of negative versus positive pressure ventilation depend on applied conditions?
### Response:
| These data do not support major biological differences between negative and positive pressure ventilation when waveforms and lung volume history are matched. |
### Instruction:
Does peripheral vasoconstriction influence thenar oxygen saturation as measured by near-infrared spectroscopy?
### Response:
| Peripheral vasoconstriction due to body surface cooling could significantly influence noninvasive measurements of thenar StO(2) using InSpectra model 650 with 15-mm probe spacing. |
### Instruction:
Do endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia?
### Response:
| These data implicate C. elegans endocytosis proteins localized at the ciliary base in regulating ciliary and periciliary membrane volume and suggest that membrane retrieval from these compartments is counterbalanced by BBS-8 and RAB-8-mediated membrane delivery. |
### Instruction:
Is tumoral CRP expression in thoracic esophageal squamous cell cancers associated with poor outcomes?
### Response:
| Tumoral CRP is associated with a poor outcome in thoracic esophageal squamous cell cancer. Tumoral CRP could therefore be an important target for the treatment of this disease. |
### Instruction:
Does cAG repeat expansion in Huntington disease determine age at onset in a fully dominant fashion?
### Response:
| Normal allele CAG length, interaction between expanded and normal alleles, and presence of a second expanded allele do not influence age at onset of motor manifestations, indicating that the rate of HD pathogenesis leading to motor diagnosis is determined by a completely dominant action of the longest expanded allele and as yet unidentified genetic or environmental factors. |
### Instruction:
Does laparoscopic gastrectomy for patients with advanced gastric cancer produce oncologic outcomes similar to those for open resection?
### Response:
| The study findings suggest that laparoscopic gastrectomy is an oncologically safe procedure for advanced gastric cancer with outcomes similar to those for open resection. |
### Instruction:
Does early entry and deformation of macropinosomes correlate with high efficiency of decaarginine-polyethylene glycol-lipid-mediated gene delivery?
### Response:
| We have shown that the existence of R10B/DNA complexes in macropinosomes at the early stages of gene delivery correlates with high efficiency R10B-mediated gene delivery. This finding will provide valuable insights for the engineering of more efficient gene delivery systems based on oligoarginine-mediated carriers. |
### Instruction:
Does neuropsychological performance predict decision-making abilities in Chinese older persons with mild or very mild dementia?
### Response:
| Neuropsychological test performance differentially predicted different decision-making abilities in older patients with mild or very mild dementia. |
### Instruction:
Do glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes?
### Response:
| These results support an important role of the presynaptic partner in the induction and differentiation of the postsynaptic structures. |
### Instruction:
Are plasma cell-free DNA levels elevated in acute Puumala hantavirus infection?
### Response:
| The plasma levels of cf-DNA are elevated during acute PUUV infection and correlate with the apoptotic cf-DNA-band intensity. The plasma cf-DNA concentration correlates with some variables reflecting the severity of the disease. The urinary excretion of cf-DNA does not reflect the degree of inflammation in the kidney. |
### Instruction:
Do fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response?
### Response:
| Fluoxetine and aripiprazole pretreatment of poly I:C offspring from postnatal days 35 to 70 stabilized response to amphetamine exposure persisting through 3 months of age, similar to earlier findings in mice that fluoxetine treatment following prenatal immune activation prevented altered locomotor response to amphetamine. The current data also confirm earlier findings of potential adverse behavioral effects in offspring of control dams following treatment with fluoxetine and antipsychotic medications, highlighting the potential for both therapeutic as well as safety concerns with exposure to preventive pharmacological treatments over the course of adolescent development. Further study is needed to determine clinical and epidemiological consequences of these pre-clinical findings. |
### Instruction:
Does acute hyperfibrinogenemia impair cochlear blood flow and hearing function in guinea pigs in vivo?
### Response:
| The effect of microcirculatory impairment on hearing function could be explained by a malfunction of the cochlear amplifier. Further investigation is needed to quantify cochlear potentials under elevated serum fibrinogen levels. |
### Instruction:
Does hIV-1 protease mutation 82M contribute to phenotypic resistance to protease inhibitors in subtype G?
### Response:
| Our results suggest that 82M has an impact on PI susceptibility and that this effect is not due to a compensatory effect on the replication capacity. Because 82M is not observed as a polymorphism in any subtype, these observations support the inclusion of 82M in drug resistance interpretation systems and PI mutation lists. |
### Instruction:
Is blood donors ' helping behavior driven by warm glow : more evidence for the blood donor benevolence hypothesis?
### Response:
| This paper offers objective behavioral evidence that blood donors' charitable giving and blood donation, compared to non-blood donors, is more strongly motivated by warm glow. This provides additional support for the benevolence hypothesis of blood donation. |
### Instruction:
Does troponin elevation predict atrial fibrillation in patients with stroke or transient ischemic attack?
### Response:
| cTnI elevation predicts new-onset AF on 24-hour Holter measurement in patients with acute ischemic stroke or TIA and may indicate a poorer prognosis and a higher risk of stroke, MI, and death at 3 months. |
### Instruction:
Does sanguisorba minor extract suppress plasmin-mediated mechanisms of cancer cell migration?
### Response:
| Our results show that the extract from Sanguisorba minor limits plasmin-mediated tumor cell motility in vitro, mostly due to quercetin-3-glucuronide. This glucuronated flavonoid is a promising template for rational designing of anticancer drugs to be used in the treatment of pathological states involving the unregulated activity of plasmin. |
### Instruction:
Does combination of alpha lipoic acid and superoxide dismutase lead to physiological and symptomatic improvements in diabetic neuropathy?
### Response:
| The combination of two powerful antioxidant agents leads to improvement in both subjective and objective parameters in patients with diabetic neuropathy. New profitable directions for investigations are opened for a non-invasive treatment of diabetic neuropathy in the future. |
### Instruction:
Is childhood sexual abuse associated with cortisol awakening response over pregnancy : preliminary findings?
### Response:
| This is the first study to show that cortisol awakening responses increase over pregnancy in women with CSA histories compared to women with CA and NA histories. |
### Instruction:
Is subpleural block less effective than thoracic epidural analgesia for post-thoracotomy pain : a randomised controlled study?
### Response:
| Thoracic epidural analgesia is superior to subpleural analgesia in relieving post-thoracotomy pain. |
### Instruction:
Does sirtuin 6 protect cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity?
### Response:
| Our findings suggest that SIRT6 suppressed cardiomyocyte hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity and that this effect was dependent on its deacetylase activity. |
### Instruction:
Is polymorphism in apoA1 Influences High-Density Lipoprotein Cholesterol Levels but a Major Risk Factor of Alzheimer 's Disease?
### Response:
| Our data support the observation that apoA1 polymorphism influences cholesterol metabolism and Aβ42 deposition in the brain. |
### Instruction:
Does stroke subtype predict outcome in young and middle-aged stroke sufferers?
### Response:
| In young and middle-aged stroke patients, stroke subtype predicts recurrent vascular events and/or death 2 years after index stroke independently of cardiovascular risk factors and stroke severity. Thus, it is important to take the etiologic subtype of IS in account when assessing the risk of recurrence both in the clinical setting and in future studies. |
### Instruction:
Are igE antibodies to animal-derived lipocalin , kallikrein and secretoglobin markers of bronchial inflammation in severe childhood asthma?
### Response:
| Multi-sensitization towards lipocalin, kallikrein and secretoglobin components is associated with increased bronchial inflammation in severe asthmatics. In addition, crossreactive patterns were observed between different lipocalin components. |
### Instruction:
Do bacterium-like particles as multi-epitope delivery platform for Plasmodium berghei circumsporozoite protein induce complete protection against malaria in mice?
### Response:
| Presentation of Plasmodium-derived antigens using BLPs as a delivery system induced complete protection in a murine malaria model. Eventually, BLPs have the potential to be used as a novel versatile delivery platform in malaria vaccine development. |
### Instruction:
Does comparison of wire and disc lead to activate the expiratory muscles in dogs?
### Response:
| These results suggest that specific configurations of wire leads, which can be placed via minimally invasive techniques, result in comparable activation of the expiratory muscles compared to disc leads and may be a useful technique to restore cough in persons with SCI. |
### Instruction:
Do transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans?
### Response:
| Our results suggest that variation in Lmf1 expression is a posttranslational determinant of LPL activity. |
### Instruction:
Do functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis?
### Response:
| The present study provides direct evidence for a previously undefined functional overlap between chondroitin sulfate proteoglycans and heparan sulfate proteoglycans during sprouting angiogenesis. Our findings provide information relevant for potential future drug design efforts that involve targeting of proteoglycans in the vasculature. |
### Instruction:
Does tissue and cellular distribution of gold nanoparticles vary based on aggregation/agglomeration status?
### Response:
| These findings raise the possibility for different mechanisms of toxicity between the structures. Such a possibility necessitates complete characterization and stability assessment of nanomaterials prior to their in vivo administration. |
### Instruction:
Does measurement of tumor volumes improve RECIST-based response assessments in advanced lung cancer?
### Response:
| Our findings indicate that measurement of changes in tumor volumes is adequately reproducible. Using tumor volumes as the basis for response assessments could have a positive impact on both patient management and clinical trials. More authoritative work to qualify or discard changes in volume as the basis for response assessments should proceed. |
### Instruction:
Does platelet-rich plasma differ according to preparation method and human variability?
### Response:
| Single-step procedures are capable of producing sufficient amounts of platelets for clinical usage. Within the evaluated procedures, platelet numbers and numbers of white blood cells differ significantly. The intra-individual results of platelet-rich plasma separations showed wide variations in platelet and cell numbers as well as levels of growth factors regardless of separation method. |
### Instruction:
Does physical activity predict changes in body image during obesity treatment in women?
### Response:
| These findings highlight the importance of PA as a contributing factor in the improvement of body image in overweight/obese women, mainly by reducing excessive salience of appearance to one's life and self. Lifestyle PA may also be a valid option, particularly in the long term. Exercise might provide a buffer against body image deterioration overtime, favoring lasting weight loss maintenance. |
### Instruction:
Do tLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle?
### Response:
| The present study supports the idea that during endurance exercise, TLR2 and TLR4 mediate a signal linking the elevated plasma NEFA concentration to the activation of p38 MAPK and JNK. |
### Instruction:
Does swimming training in rats increase cardiac MicroRNA-126 expression and angiogenesis?
### Response:
| This study showed that aerobic training promotes an increase in the expression of miRNA-126 and that this may be related to exercise-induced cardiac angiogenesis, by indirect regulation of the VEGF pathway and direct regulation of its targets that converged in an increase in angiogenic pathways, such as MAPK and PI3K/Akt/eNOS. |
### Instruction:
Does overexpression of PFTK1 predict resistance to chemotherapy in patients with oesophageal squamous cell carcinoma?
### Response:
| PFTK1 is not only useful as a prognostic marker, but also as a predictor of the response to chemotherapy. |
### Instruction:
Do non-hispanic whites have higher risk for pulmonary impairment from pulmonary tuberculosis?
### Response:
| Despite controlling for cigarette smoking, socioeconomic status and time to beginning TB treatment, non-Hispanic White race/ethnicity remained an independent predictor for disproportionately frequent and severe pulmonary impairment after tuberculosis relative to other race/ethnic groups. Since race/ethnicity was self reported and that race is not a biological construct: these findings must be interpreted with caution. However, because race/ethnicity is a proxy for several other unmeasured host, pathogen or environment factors that may contribute to disparate health outcomes, these results are meant to suggest hypotheses for further research. |
### Instruction:
Is postorthodontic external root resorption in root-filled teeth influenced by interleukin-1β polymorphism?
### Response:
| The development of EARR in subjects with root-filled teeth who undergo orthodontic treatment might be attributable to genetic variations in the interleukin-1β gene (rs1143634). |
### Instruction:
Does age modulate the effect of COMT genotype on delay discounting behavior?
### Response:
| These results confirm our previous finding of enhanced delay-discounting among val/val adults relative to met-allele carriers, and help reconcile existing literature. We propose a single U-shaped model of the relationship between frontal DA levels and impulsive choice that accounts for both adolescent and adult data. |
### Instruction:
Is sox10 expressed in primary melanocytic neoplasms of various histologies but not in fibrohistiocytic proliferations and histiocytoses?
### Response:
| This is a retrospective study with 145 cases included. |
### Instruction:
Is β-catenin a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis?
### Response:
| The present study findings identify β-catenin as a key player of fibroblast activation and tissue fibrosis in SSc. Although further translational studies are necessary to test the efficacy and tolerability of β-catenin/Wnt inhibition in SSc, the present findings may have clinical implications, because selective inhibitors of β-catenin/Wnt signaling have recently entered clinical trials. |
### Instruction:
Does [ Resolvin E1 protect against ox-LDL-induced injury on vascular endothelial cells ]?
### Response:
| The present data showed that RvE1 could effectively protect against ox-LDL-induced endothelial cell injury, which might be mediated by PI3K-AKT signaling pathway. |
### Instruction:
Does [ Atorvastatin protect swine bone marrow mesenchymal stem cells from apoptosis through AMPK but not PI3K/Akt pathway ]?
### Response:
| Atorvastatin can protect MSCs from H/SF induced apoptosis through AMPK pathway, which resulting in activation of eNOS. |
### Instruction:
Is reduced positive affect ( anhedonia ) independently associated with 7-year mortality in patients treated with percutaneous coronary intervention : results from the RESEARCH registry?
### Response:
| Anhedonia was independently associated with a 1.5-fold increased risk for all-cause mortality in patients who survived the first 6 months post-PCI. Enhancing positive emotions, in addition to reducing negative emotions, may constitute an important target for future psychological intervention trials in CAD patients. |
### Instruction:
Is chronic fatigue associated with increased disease-related worries and concerns in inflammatory bowel disease?
### Response:
| Chronic fatigue is associated with increased levels of disease-related worries and concerns in IBD. Increased levels of worries were also associated with impaired health-related quality of life. |
### Instruction:
Does level of 8-OHdG in drained dialysate appear to be a marker of peritoneal damage in peritoneal dialysis?
### Response:
| The level of 8-OHdG in drained dialysate may be a useful novel marker of peritoneal damage in PD. |
### Instruction:
Does substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevent recurrence of Hepatitis B after liver transplantation?
### Response:
| Substitution of TDF/FTC for HBIg prevented recurrence of HBV DNA in 100% (20/20) of patients who were compliant with the medication and led to substantial cost savings over HBIg-containing regimens. |
### Instruction:
Does novel chitosan-polycaprolactone blend as potential scaffold and carrier for corneal endothelial transplantation?
### Response:
| A ratio of 75:25 (chitosan:PCL) blends showed enough mechanical properties as well as suitable support for cellular activity in cultivating BCECs. Thus, a novel methodology of biodegradable carrier from chitosan and PCL has potential to be a good replacement scaffold for raising CECs for clinical transplantation. |
### Instruction:
Does silencing of insulin receptor substrate-1 increase cell death in retinal Müller cells?
### Response:
| In these studies, we show for the first time that salmeterol, a beta-2-adrenergic receptor agonist, can reduce retinal Müller cell death through IRS-1 actions. These findings also suggest the importance of IRS-1 in beta-adrenergic receptor signaling in the prevention of cell death in retinal Müller cells. |
### Instruction:
Do variations in LOXL1 associated with exfoliation glaucoma affect amine oxidase activity?
### Response:
| The R141L and G153D variations in the NH(2)-terminal region of LOXL1 do not affect the amine oxidase activity of LOXL1. This is consistent with recent genetic findings on the reversal of risk alleles of R141L and G153D in different ethnic backgrounds. Our results suggest that other unknown genetic factors or molecular mechanisms may be more relevant to the development of XFG. |
### Instruction:
Does rpgrORF15 connect to the usher protein network through direct interactions with multiple whirlin isoforms?
### Response:
| Whirlin expression has been reported in photoreceptors and cochlear hair cells, and mutations in whirlin cause Usher syndrome (USH2D) and nonsyndromic congenital deafness (DFNB31). Because mutations in the 5' end of whirlin are associated with the syndromic phenotype associated with USH2D, the identification of novel N-terminal isoforms in the retina and a novel RPGR(ORF15)-whirlin interaction provide a potential mechanism for the retinal phenotype observed in USH2D. |
### Instruction:
Does electroconvulsive therapy improve antipsychotic and somnographic responses in adolescents with first-episode psychosis -- a case-control study?
### Response:
| ECT is an effective and safe intervention used in adolescents with first-episode psychosis. Its antipsychotic effects are associated with improved PSG variables. ECT can be considered as an early psychosis intervention. |
### Instruction:
Do different mechanisms preserve translation of programmed cell death 8 and JunB in virus-infected endothelial cells?
### Response:
| We show that microarray profiling of polyribosomal mRNA transcripts from PV-infected ECs successfully identifies mRNAs whose translation is preserved in the face of stress-induced, near complete cessation of cap-dependent initiation. Nevertheless, internal ribosome entry is not the only mechanism responsible for this privileged translation. |
### Instruction:
Is high expression of microRNA-210 an independent factor indicating a poor prognosis in Japanese triple-negative breast cancer patients?
### Response:
| The degree of miR-210 expression might be a clinically useful prognostic factor for decision-making regarding treatment in the adjuvant setting, especially in node-negative triple-negative breast cancer patients. |
### Instruction:
Is elevated blood urea nitrogen/creatinine ratio associated with poor outcome in patients with ischemic stroke?
### Response:
| An elevated BUN/Cr ratio in patients with AIS is associated with poor outcome at 30 days. Further study is needed to see if acutely addressing hydration status in ED patients with AIS can alter outcome. |
### Instruction:
Does clean Indoor Air act reduce the burden of adverse cardiovascular outcomes?
### Response:
| State/territory-wide CIAAs are beneficial in reducing adverse cardiovascular health outcomes in the short term. The prevalence of AMI, CHD/angina, and former and current smokers decreased significantly following CIAA implementation. The current study adds further support for the passage and implementation of CIAAs on a state/territory-wide level. However, further studies need to be conducted to assess the long-term outcomes of CIAAs. |
### Instruction:
Do dNMT inhibitors and HDAC inhibitors regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo?
### Response:
| A combination of HDACIs and DNMTIs suppresses the growth of EC, which is likely mediated by upregulation of E-cadherin and downregulation of Bcl-2. |
### Instruction:
Does peginterferon-α improve early peripheral blood HBV-specific T-cell responses in HBeAg-negative chronic hepatitis?
### Response:
| IFN-α did not improve peripheral blood HBV-specific T-cell responses in the first 24 weeks of treatment, consistent either with a predominant antiviral/antiproliferative effect or with an immunomodulatory activity on other arms of the immune system which were not analyzed in our study. A better pre-treatment ex vivo IFN-γ production was associated with better chances to control HBV replication during therapy and represents a promising predictor of IFN efficacy. |
### Instruction:
Is lack of TGF-β production by hepatitis C virus-specific T cells during HCV acute phase associated with HCV clearance in HIV coinfection?
### Response:
| During acute hepatitis C, pre-therapeutic HCV-specific TGF-β-producing T cells are a new marker independent of the IL-28B gene polymorphism, predicting the lack of spontaneous or therapeutic HCV clearance. |
### Instruction:
Does a large study reveal no association between APOE and Parkinson 's disease?
### Response:
| There is no association between APOE epsilon alleles and Parkinson's disease. |
### Instruction:
Are steroid requirements and immune associations with vitamin D stronger in children than adults with asthma?
### Response:
| This study demonstrated significant associations between serum vitamin D status and steroid requirement and in vitro responsiveness to corticosteroids in the pediatric but not the adult asthma group. Vitamin D was also related to IgE levels in children but not in adults. |
### Instruction:
Do adults with Down syndrome have reduced cardiac response after light exercise testing?
### Response:
| CI at rest was similar in adults with DS and controls; however persons with DS have a diminished cardiac response to exercise. Stroke volumes were significantly lower in DS during exercise and a compensated heightened heart rate was absent. |
### Instruction:
Is dysfunctional coping in headache : avoidance and endurance associated with chronic forms of headache?
### Response:
| Dysfunctional coping was seen with high prevalence in the entire patient sample (66%). Against our hypothesis, it was not confined to chronic forms of headache. In respect to our data, we discuss the role of avoidance and endurance coping in headache and its possible role in chronicity. |
### Instruction:
Does lBD29 regulate the cell cycle progression in response to auxin during lateral root formation in Arabidopsis thaliana?
### Response:
| The ability of LBD29 to regulate lateral root initiation is associated with its maintenance of the cell division capacity of the pericycle in response to auxin and its involvement in the auxin signalling pathway. |
### Instruction:
Does blue mode offer any benefit over white light when calculating Lewis score in small-bowel capsule endoscopy?
### Response:
| Although BM is believed to enhance mucosal details i.e., small mucosal breaks, it did not perform better than WL in the calculation of LS in our cohort. |
### Instruction:
Do extracorporeal shock wave therapy for the management of burn scars?
### Response:
| Extracorporeal shock wave therapy is a feasible and cost-effective treatment in the management of postburn pathologic scars. |
### Instruction:
Does online detection of error-related potentials boost the performance of mental typewriters?
### Response:
| The performance of BCIs can be increased by using an automatic error detection mechanism. The benefit for patients with motor disorders is potentially high since they often have rather low spelling accuracies compared to healthy people. |
### Instruction:
Is delaying progression to type 2 diabetes among high-risk Spanish individuals feasible in real-life primary healthcare settings using intensive lifestyle intervention?
### Response:
| Intensive lifestyle intervention is feasible in a primary care setting and substantially reduces diabetes incidence among high-risk individuals. |
### Instruction:
Do patients with endometriosis of the rectosigmoid have a higher percentage of natural killer cells in peripheral blood?
### Response:
| Compared with patients without endometriosis, those with endometriosis demonstrate a higher concentration of peripheral NK cells. The percentage of NK cells is greater, primarily in patients with advanced stages of endometriosis involving the rectosigmoid colon. Therefore, it may serve as a diagnostic marker for this type of severe endometriosis, in particular if considered in conjunction with the symptoms. |
### Instruction:
Does myocardial remodeling after large infarcts in rat convert post rest-potentiation in force decay?
### Response:
| Our results showed, for the first time ever, that myocardial remodeling after MI in rats may change the regular potentiation to post-rest decay by affecting myocyte Ca(2+) handling proteins. |
### Instruction:
Does sufentanil reduce emergence agitation in children receiving sevoflurane anesthesia for adenotonsillectomy compared with fentanyl?
### Response:
| Administration of sufentanil at 0.2 µg/kg after induction of anesthesia reduced emergence agitation in children receiving sevoflurane anesthesia for adenotonsillectomy compared with fentanyl. This was without delaying the recovery time or causing significant hypotension. |
### Instruction:
Is asian ethnicity associated with a higher trunk/peripheral fat ratio in women and adolescent girls?
### Response:
| These results confirm previous reports of greater central adiposity in women of Asian ancestry and indicate that ethnic differences in adiposity are already present in adolescence. |
### Instruction:
Does disruption of Trp53 in livers of mice induce formation of carcinomas with bilineal differentiation?
### Response:
| Deletion of p53 from livers of mice is sufficient to induce tumor formation. The tumors have bilineal differentiation and dysregulation of Rb checkpoint genes. |
### Instruction:
Does bone regeneration in distraction osteogenesis demonstrate significantly increased vascularity in comparison to fracture repair in the mandible?
### Response:
| We report robust and quantifiable increases in vascular density in DO compared with FxR. Our findings support a significant distinction between the regenerative processes of mandibular DO from the reparative mechanisms controlling fracture healing. A better understanding of the differences between the 2 types of bone formation may enable clinicians to selectively optimize therapeutic outcomes in the future. |
### Instruction:
Does [ Perioperative use of fluidwarmers reduce hypothermia in cats ]?
### Response:
| The present study shows that warmed IV infusions have a significant influence on the reduction of perioperative heat loss in cats. Nevertheless other additional methods to prevent heat loss are necessary to keep the patient in a normothermic range. Room temperatures play an essential role in decreasing hypothermia and should be at least 26°C. Low body temperature at the end of anaesthesia prolongs the recovery periode and enhances postoperative shivering. |
### Instruction:
Does mercury in serum predict low risk of death and myocardial infarction in Gothenburg women?
### Response:
| There was a strong inverse association between Hg exposure and CVD. Likely, reasons are confounding with good dental health (also correlated with the number of amalgam fillings in these age groups) and/or fish consumption. The results suggest potential effects of dental health and/or fish consumption on CVD that deserve attention in preventive medicine. |
### Instruction:
Does up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulate colon-to-bladder cross-sensitization in rat?
### Response:
| Acute colonic inflammation increases bladder activity without affecting bladder morphology. Primary afferent-mediated BDNF up-regulation in the sensory neurons regulates, at least in part, the bladder activity during colonic inflammation. |
### Instruction:
Does gestational weight loss have adverse effects on placental development?
### Response:
| GWL is associated with SGA, small placenta, short umbilical cord length, preterm delivery and pPROM. |
### Instruction:
Does glycine transporter type 2 ( GlyT2 ) inhibitor ameliorate bladder overactivity and nociceptive behavior in rats?
### Response:
| During cystometry in CYP-treated rats, significant increases in intercontraction interval and micturition pressure threshold were elicited by ALX-1393, a selective GlyT2 inhibitor, but not by sarcosine, a GlyT1 inhibitor. These effects were completely reversed by strychnine, a GlyR antagonist. ALX-1393 also significantly suppressed nociceptive behaviors in a dose-dependent manner. In sham rats, GlyT2 mRNA was expressed at a much higher level (23-fold) in the dorsal spinal cord than GlyT1 mRNA. In CYP-treated rats, mRNA levels of GlyT2 and the GlyR α1 and β subunits were significantly reduced. |
### Instruction:
Are primary care-based interventions associated with increases in hepatitis C virus testing for patients at risk?
### Response:
| Two simple clinical reminder interventions were associated with significantly increased HCV testing rates. Our findings suggest that HCV screening programs, using either a risk-based or birth cohort strategy, should be adopted in primary care settings so that HCV-infected patients may benefit from antiviral treatment. |
### Instruction:
Is the functional Ser326Cys polymorphism in hOGG1 associated with gastric cancer risk : evidence from 1180 cases and 2444 controls?
### Response:
| Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer. |
### Instruction:
Do peptide markers of aminoacyl tRNA synthetases facilitate taxa counting in metagenomic data?
### Response:
| A major advantage of our method is its simplicity: it relies on searching sequences for the occurrence of just 4000 specific peptides belonging to the S61 subgroup of aaRS enzymes. When compared to other methods, it provides additional insight into the taxonomic contents of metagenomic data. Furthermore, it can be directly applied to short read data, avoiding the need for genomic contig reconstruction, and taking into account short reads that are otherwise discarded as singletons. Hence it is very suitable for a fast analysis of next generation sequencing data. |
### Instruction:
Is bMPR2 expression suppressed by signaling through the estrogen receptor?
### Response:
| BMPR2 gene expression is reduced in females compared to males in live humans and in mice, likely through direct estrogen receptor alpha binding to the BMPR2 promoter. This reduced BMPR2 expression may contribute to the increased prevalence of PAH in females. |
### Instruction:
Is selective pulmonary artery perfusion with melphalan equal to isolated lung perfusion but superior to intravenous melphalan for the treatment of sarcoma lung metastases in a rodent model?
### Response:
| SPAP with MN for the treatment of sarcoma lung metastases in rats is equally effective to ILuP but resulted in a significantly better survival compared with IV MN. As SPAP can be applied as a minimally invasive endovascular procedure, continued research with this technique is warranted. |
### Instruction:
Does the location of the primary entry tear in acute type B aortic dissection affect early outcome?
### Response:
| A primary entry tear at the concavity of the aortic arch as well as a short distance between the primary entry tear and the left subclavian artery are frequently associated with the presence or the development of complicated acute type B aortic dissection. These findings shall help us to further differentiate acute type B aortic dissections in addition to the common categorization in complicated and uncomplicated. These findings may therefore also have an impact on primary treatment. |
### Instruction:
Does plasma profiling by a protein array approach identify IGFBP-1 as a novel biomarker of abdominal aortic aneurysm?
### Response:
| IGFBP-1 has been identified by a protein array approach as a potential novel biomarker of AAA. The biological role of IGFBP-1 in AAA pathogenesis could be related to the modulation on the effect of IGF-1 on platelet aggregation. |
### Instruction:
Is an encapsulated Yersinia pseudotuberculosis a highly efficient vaccine against pneumonic plague?
### Response:
| The encapsulated Y. pseudotuberculosis V674pF1 is an efficient live oral vaccine against pneumonic plague, and could be developed for mass vaccination in tropical endemic areas to control pneumonic plague transmission and mortality. |
### Instruction:
Does adiponectin regulate functions of gingival fibroblasts and periodontal ligament cells?
### Response:
| Our observations demonstrate that adiponectin exerts anti-inflammatory effects on HGFs and MGFs, and promotes the activities of osteoblastogenesis of HPDL cells. We conclude that adiponectin has potent beneficial functions to maintain the homeostasis of periodontal health, improve periodontal lesions, and contribute to wound healing and tissue regeneration. |
### Instruction:
Does akt-centered amplification loop play a critical role in vascular endothelial growth factor/stromal cell-derived factor 1-α cross-talk and cardioprotection?
### Response:
| VEGF has direct protective effects on cardiomyocytes; a crosstalk between VEGF and SDF-1α through PI3K-Akt serves a survival role in cardiomyocytes in vitro. |
### Instruction:
Does inhibition of connective tissue growth factor overexpression decrease growth of hepatocellular carcinoma cells in vitro and in vivo?
### Response:
| CTGF was overexpressed in human HCC cells and downregulation of CTGF inhibited HCC growth in vitro and in vivo. Knockdown of CTGF may be a potential therapeutic strategy for treatment of HCC. |
### Instruction:
Does dexamethasone increase susceptibility of Aspergillus fumigatus to hydrogen peroxide via down-regulation of Afyap1 gene expression in vitro?
### Response:
| Dexamethasone can have A. fumigatus being more susceptible to ROS when treated for shorter period (0.5 to 2 hours) via the reduction of Afyap1 gene expression as well as the down-stream enzyme-coding gene expression. |
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