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### Instruction:
Do akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse large B-cell lymphoma?
### Response:
| GEP identifies DLBCL subsets resistant to mTOR inhibitor therapy. Combined targeting of mTOR and Akt suppresses activation of key components of the Akt/mTOR pathway and results in synergistic cytotoxicity. These findings are readily adaptable to clinical trials. |
### Instruction:
Do heme oxygenase-1 end-products carbon monoxide and biliverdin ameliorate murine collagen induced arthritis?
### Response:
| Our data demonstrate a beneficial effect of CO, in particular, and biliverdin, on inflammation and bone destruction in the CIA mouse model. |
### Instruction:
Is preoperative enoxaparin safe to use in major gynecologic surgery for prophylaxis of venous thromboembolism : a retrospective cohort study?
### Response:
| The use of preoperative enoxaparin is not associated with increased blood loss, transfusion requirements, operative time, or hospital stay among patients having major gynecologic surgery. |
### Instruction:
Do food access and diet quality independently predict nutritional status among people living with HIV in Uganda?
### Response:
| Our results provide an empirical basis for focused efforts on improving food access and diet quality among PLWHIV. Addressing the broader structural determinants of food security of people infected and affected by HIV is crucial. |
### Instruction:
Are serum levels of GRO-α elevated in association with disease activity in patients with Behçet 's disease?
### Response:
| Our results indicate that serum levels of GRO-α are elevated in patients with active stage BD, suggesting that GRO-α may serve as a reliable marker for disease activity of BD. |
### Instruction:
Are [ The invasion ability and expressions of matrix metalloproteinase-13 and calcium-binding protein S100A4 inhibited by hyperthermia in human Tca8113 cells ]?
### Response:
| The invasion of Tca8113 could be inhibited by hyperthermia. The mechanism of this effect may be due to protein expression inhibition of MMP-13 and S100A4. |
### Instruction:
Does local delivery of a direct renin inhibitor into the kidney ameliorate progression of experimental glomerulonephritis?
### Response:
| This study revealed that renally delivered aliskiren has a renoprotective effect on potentially progressive glomerulosclerosis. |
### Instruction:
Do hypertonic saline downregulate the production level of lipopolysaccharide-induced migration inhibitory factor in THP-1 cells?
### Response:
| The role of HTS in maintaining physiological balance in human beings, at least in part, should be mediated through the MIF pathway. |
### Instruction:
Does intraoperative blood transfusion contribute to decreased long-term survival of patients with esophageal cancer?
### Response:
| Intraoperative blood loss could be a useful prognostic factor following radical esophagectomy in patients with esophageal squamous cell carcinoma. |
### Instruction:
Does interim fluoro-2-deoxy-D-glucose-PET predict response and progression-free survival in patients with Hodgkin lymphoma and HIV infection?
### Response:
| A negative interim 18F-FDG PET result is highly predictive of treatment success in HIV-HL patients. |
### Instruction:
Is chronic lymphocytic leukemia associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based study?
### Response:
| Patients with CLL before diagnosis of MM or MCC have significantly worse OS and MM or MCC cause-specific survival than those without a history of CLL/NHL. |
### Instruction:
Is roundabout required in the visceral mesoderm for proper microvillus length in the hindgut epithelium?
### Response:
| Together, these results establish a novel, dose-dependent role for Robo in regulating microvilli growth and provide in vivo evidence for the role of the visceral mesoderm in controlling morphological changes in the underlying intestinal epithelium. |
### Instruction:
Is aberrant anterior cingulate activation in obsessive-compulsive disorder related to task complexity?
### Response:
| Present findings provide further support for the relevance of the anterior cingulate in OCD and illustrate that both task demands and task processes are of major influence in this context. |
### Instruction:
Are antigen specific T-cell responses against tumor antigens controlled by regulatory T cells in patients with prostate cancer?
### Response:
| Tumor specific effector T cells were detected in most patients with prostate cancer, especially those with castration resistant prostate cancer. Since effector T-cell responses against prostate specific antigens strongly increased after regulatory T-cell depletion, our results indicate that immunotherapy efficacy could be enhanced by decreasing regulatory T cells. |
### Instruction:
Is expression of estrogen receptor alpha and beta decreased in hypospadias?
### Response:
| These data demonstrate a difference in estrogen receptor α and β expression and location in the foreskin of patients with hypospadias compared to controls. These findings are consistent with aberrant estrogenic effects having a role in the etiology of hypospadias. |
### Instruction:
Does prior statin use have no effect on survival after intracerebral hemorrhage in a multiethnic Asian patient cohort?
### Response:
| No beneficial effect on survival after ICH of prior statin use could be demonstrated in our large multi-ethnic Asian patient cohort. |
### Instruction:
Does pressure reactivity index correlate with metabolic dysfunction in a porcine model of intracerebral hemorrhage?
### Response:
| We found evidence for impaired CR in a porcine model of ICH. The findings suggest that, among other parameters of CR, positive PRx coefficients have the highest significance and could be associated with microdialysis alterations during hypoxic events. |
### Instruction:
Is the growth response to androgen receptor signaling in ERα-negative human breast cells dependent on p21 and mediated by MAPK activation?
### Response:
| These studies present a new model for the analysis of AR signaling in human breast epithelial cells lacking ERα/PR expression, providing an experimental system without the potential confounding effects of ERα/PR crosstalk. Using this system, we provide a mechanistic explanation for previous observations ascribing a dual role for AR signaling in human breast cancer cells. As previous reports have shown that approximately 40% of breast cancers can lack p21 expression, our data also identify potential new caveats for exploiting AR as a target for breast cancer therapy. |
### Instruction:
Does telbivudine prevent vertical transmission from HBeAg-positive women with chronic hepatitis B?
### Response:
| Women with CHB given telbivudine during the second or third trimester of pregnancy have reduced rates of perinatal transmission. Telbivudine produced no adverse events in mothers or infants by 28 weeks. |
### Instruction:
Does liver biopsy analysis have a low level of performance for diagnosis of intermediate stages of fibrosis?
### Response:
| Biopsy has a low level of diagnostic performance for fibrosis stages F2 and F1. The recommendation for biopsy analysis, instead of a validated biomarker panel such as FibroTest, for the diagnosis of intermediate stages of fibrosis is therefore misleading. |
### Instruction:
Does ultrasonography reveal a high prevalence of lower spinal dysraphism in children with urogenital anomalies?
### Response:
| The prevalence of OSD in children under 24 months of age with simple urogenital anomaly was higher than what was reported for the general population. Ultrasound examination of spinal structures before caudal block in children with urogenital anomaly should be considered. |
### Instruction:
Are high cholesterol levels associated with coronary microvascular dysfunction?
### Response:
| Our data obtained with invasive measurement of microvascular resistance suggest a significant correlation between cholesterol levels and coronary microvascular dysfunction. |
### Instruction:
Is the effect of catechol-O-methyltransferase polymorphisms on pain modified by depressive symptoms?
### Response:
| Our results indicate that variants within the COMT gene are associated with pain perception. However, this association is highly moderated by the absence or presence of lifetime depressive symptoms. |
### Instruction:
Do cognitive deficits in adults with ADHD go beyond comorbidity effects?
### Response:
| Neuropsychological deficits in adults with ADHD go beyond comorbidity. Specific comorbid disorders may influence the neuropsychological functioning in adults with ADHD. |
### Instruction:
Is pulse-wave analysis of optic nerve head circulation significantly correlated with brachial-ankle pulse-wave velocity , carotid intima-media thickness , and age?
### Response:
| Our results confirmed measurements of BOT in the optic nerve head can be a useful method for determinin g whether early atherosclerotic changes are present in the optic nerve head circulation. |
### Instruction:
Is erectile dysfunction frequent in systemic sclerosis and associated with severe disease : a study of the EULAR Scleroderma Trial and Research group?
### Response:
| Severe ED is a common and early problem in men with SSc. Physicians should address modifiable risk factors actively. More research into the pathophysiology, longitudinal development, treatment and psychosocial impact of ED is needed. |
### Instruction:
Is neck circumference an accurate and simple index for evaluating overweight and obesity in Han children?
### Response:
| The present study demonstrates that NC is a simple, inexpensive and accurate measurement that may be used to identify overweight and obesity in Han children. |
### Instruction:
Is e-mail management of the modified Atkins Diet for adults with epilepsy feasible and effective?
### Response:
| E-mail administration of the MAD to adults with refractory epilepsy appears to be feasible and effective. Therefore, when dietitian or physician support is limited for adult patients with epilepsy, remote access via telemedicine could provide an alternative. |
### Instruction:
Does penaeus monodon thioredoxin restore the DNA binding activity of oxidized white spot syndrome virus IE1?
### Response:
| WSSV's pathogenicity is enhanced by the virus' use of host Trx to rescue the DNA binding activity of WSSV IE1 under oxidizing conditions. |
### Instruction:
Is cCND1 G870A polymorphism associated with increased risk of colorectal cancer , especially for sporadic colorectal cancer and in Caucasians : a meta-analysis?
### Response:
| CCND1 G870A polymorphism is associated with the increased risk of colorectal cancer, especially for sporadic colorectal cancer and in Caucasians. |
### Instruction:
Does pattern of lymph node metastasis correlate with tumor location in bladder cancer?
### Response:
| The location of the bladder tumor and direction of metastatic spread were significantly correlated. Mandatory bilateral lymphadenectomy during radical cystectomy should be questioned. |
### Instruction:
Is cardiac catheterization within 1 to 3 days of proximal aortic surgery associated with increased postoperative acute kidney injury?
### Response:
| Cardiac catheterization within 1 to 3 days of elective proximal aortic surgery appears safe and should be considered acceptable practice for patients at low risk of acute kidney injury. |
### Instruction:
Does menopause affect pain depending on pain type and characteristics?
### Response:
| The present study provides preliminary data suggesting that menopause can affect pain depending on the painful condition experienced by the woman. This underlines the different interactions of menopause-related events with body structures involved in pain. |
### Instruction:
Does periodontal inflammatory burden correlate with C-reactive protein serum level?
### Response:
| This new method quantifies the inflammatory burden caused by periodontal disease. The size of the inflammatory burden is correlated with increased serum levels of CRP. |
### Instruction:
Do drug release patterns and cytotoxicity of PEG-poly ( aspartate ) block copolymer micelles in cancer cells?
### Response:
| Ionic interaction appeared to entrap DOX efficiently in polymer micelles from PEG-p(Asp) block copolymers. Polymer micelles possessing counter ions (Na) of DOX in the core were the most stable, releasing drugs for prolonged time in a pH-dependent manner, and suppressing cancer cells effectively. |
### Instruction:
Is certolizumab pegol plus MTX administered every 4 weeks effective in patients with RA who are partial responders to MTX?
### Response:
| CZP 400 mg every 4 weeks plus MTX demonstrated a favourable risk-benefit profile with rapid onset of action in RA patients with an inadequate response to an earlier MTX therapy. |
### Instruction:
Is immune thrombocytopenia in patients with chronic lymphocytic leukemia associated with stereotyped B-cell receptors?
### Response:
| Our data suggest that patients with CLL and peculiar BCR conformations are at higher risk of developing secondary ITP and that stereotyped BCR may be involved in the pathogenesis of this complication. |
### Instruction:
Does social adaptability index predict overall mortality in patients with diabetes?
### Response:
| Social adaptability index is associated with mortality in the diabetic population and is useful in identifying individuals who are at risk for inferior outcomes. |
### Instruction:
Does detection of the third and fourth heart sound using Hilbert-Huang transform?
### Response:
| The proposed method is adaptive for detecting low-amplitude and low-frequency S3 and S4 simultaneously compared with previous detection methods, which would be practical in primary care. |
### Instruction:
Is pollen-specific immunoglobulin E positivity associated with worsening of depression scores in bipolar disorder patients during high pollen season?
### Response:
| To our knowledge, this is the first report of coupling a molecular marker of vulnerability (allergen-specific IgE) with a specific environmental trigger (airborne allergens) leading to exacerbation of depression in patients with bipolar I disorder. |
### Instruction:
Is olfactory acuity associated with mood and function in a pilot study of stable bipolar disorder patients?
### Response:
| Diminished odor detection sensitivity predicted mania and social avoidance, whereas more sensitive odor detection predicted more depressive symptoms but better employment functioning in bipolar disorder patients. Odor acuity may be an illness state marker of mood syndromes in bipolar disorder. Alternatively, differences in odor acuity may identify heterogeneous subgroups within the bipolar spectrum. Longitudinal assessments in a large, sex-stratified sample are needed to understand the implications of odor sensitivity in patients with bipolar disorder. |
### Instruction:
Does candesartan improve impaired endothelial function in the human coronary artery?
### Response:
| Our results suggest that candesartan improves coronary endothelial dysfunction of human coronary arteries and may prevent cardiac events. |
### Instruction:
Does computational analysis of pathogen-borne metallo β-lactamases reveal discriminating structural features between B1 types?
### Response:
| A discriminating linker region identified in MBL proteins is highlighted and examined in the context of NDM-1 and primarily three other MBL types: IMP-1, VIM-2 and ccrA. The presence of an unusual linker region variant and uncommon amino acid composition at specific structurally important sites may help to explain the unusually broad kinetic profile of NDM-1 and may aid in directing research attention to areas of this protein, and possibly other MBLs, that may be targeted for inactivation or attenuation of enzymatic activity. |
### Instruction:
Does diet supplementation with green tea extract epigallocatechin gallate prevent progression to glucose intolerance in db/db mice?
### Response:
| This study shows that the green tea extract EGCG markedly preserves islet structure and enhances glucose tolerance in genetically diabetic mice. Dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes. |
### Instruction:
Is femoral anteversion correlated with acetabular version and coverage in Asian women with anterior and global deficient subgroups of hip dysplasia : a CT study?
### Response:
| Our results showed significantly greater and more variable femoral anteversion in DDH, and a significant correlation between femoral anteversion and acetabular version and coverage in DDH with anterior and global acetabular bone deficiency. |
### Instruction:
Is angiogenic remodeling in pediatric EoE associated with increased levels of VEGF-A , angiogenin , IL-8 , and activation of the TNF-α-NFκB pathway?
### Response:
| We demonstrate increased angiogenesis in the esophageal mucosa of pediatric patients with EoE. The data also provided evidence that the angiogenic factors VEGF-A, angiogenin, and IL-8 were prominently involved in promoting angiogenic remodeling. |
### Instruction:
Do gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome?
### Response:
| Gastrointestinal and nutritional problems perceived by parents are prevalent throughout life in girls and women with RTT and may pose a substantial medical burden for their caregivers. Physician awareness of these features of RTT may improve the health and quality of life of individuals affected with this disorder. |
### Instruction:
Is reduced expression of PER3 associated with incidence and development of colon cancer?
### Response:
| PER3 may play a role in colon cancer progression. |
### Instruction:
Is angiotensin converting enzyme DD genotype associated with acute coronary syndrome severity and sudden cardiac death in Taiwan : a case-control emergency room study?
### Response:
| This study demonstrated that the ACE DD genotype is an independent risk factor for ACS, and in particular, for acute myocardial infarction. In addition, the ACE DD genotype is also associated with greater ACS severity and a higher risk of sudden cardiac death. ACE genotyping is recommended for patients with a history of ACS, and more intensive preventive care is suggested for patients with the DD genotype. |
### Instruction:
Does population screening for coronary artery calcification increase mental distress and the use of psychoactive medication?
### Response:
| A population screening program including CAC score appears to have no detrimental impact on mental distress and does not increase the use of psychoactive medication. |
### Instruction:
Are triphasic and quadriphasic waveforms superior to biphasic waveforms for synchronized beating of cardiomyocytes?
### Response:
| The MEA system allows for a straightforward manner to investigate effects of waveform design on synchronized beating in cardiomyocytes in vitro. Increased number of phase changes in a pacing waveform seems to be the major reason for the reduction in synchronizing amplitudes. |
### Instruction:
Is the N355K atlastin 1 mutation associated with hereditary sensory neuropathy and pyramidal tract features?
### Response:
| Our family carrying the N355K ATL1 mutation, which was initially diagnosed as HSN I, enlarges the SPG3A phenotype. We therefore suggest that patients with HSN I excluded for more common causes of HSN I, and in particular, affected individuals who exhibit additional pyramidal tract features should also be screened for mutations in ATL1. |
### Instruction:
Is the secretion pattern of perivascular fat cells different from that of subcutaneous and visceral fat cells?
### Response:
| Perivascular (pre-)adipocytes differ substantially from other fat cells with regard to mRNA expression and protein production of angiogenic factors. This may contribute to fat tissue growth and atherosclerotic plaque complications. Higher levels of angiogenic factors, such as HGF, in patients with increased perivascular fat mass may have pathological relevance. |
### Instruction:
Does factor structure and correlate of the acceptance of cosmetic surgery scale among South Korean university students?
### Response:
| The results reveal important global information for plastic surgeons-not only on the treatment of non-Western patients but on the South Korean market, in which the cosmetic surgery industry remains unregulated. Given the popularity and acceptance of cosmetic surgery in South Korea, there is an urgent need for regulatory intervention to ensure patient safety and satisfaction. |
### Instruction:
Does [ X-ray induce autophagy in human mesenchymal stem cells ]?
### Response:
| Irradiation may induce the autophagy in hBMMSC, and autophagy could protect hBMMSC from irradiation injury in a certain dose range. |
### Instruction:
Does activin Receptor-Like Kinase 5 Inhibitor attenuate Fibrosis in Fibroblasts Derived from Peyronie 's Plaque?
### Response:
| Overexpression of TGF-β and activation of Smad transcriptional factors are known to play a crucial role in the pathogenesis of PD. Thus, inhibition of the TGF-β signaling pathway by ALK5 inhibitor may represent a promising therapeutic strategy for treating PD. |
### Instruction:
Does increased gut microbial translocation in HIV-infected children persist in virologic responders and virologic failures after antiretroviral therapy?
### Response:
| MT persists after 44 weeks of antiretroviral therapy in VS and VF patients. In VF, 16SrDNA exhibited relationships to monocyte and T cell IA and CD4 counts but not with viral load, suggesting a dominant role for MT in disease pathogenesis in HIV-infected children. |
### Instruction:
Are revision surgeries associated with significant increased risk of subsequent cerebrospinal fluid shunt infection?
### Response:
| Although younger age is associated with increased hazard of infection, subsequent CSF shunt revision significantly increases infection risk. |
### Instruction:
Are expression of DSG1 and DSC1 prognostic markers in anal carcinoma patients?
### Response:
| Membrane negativity for DSG1 and cytoplasmic negativity for DSC1 are favourable markers for CSS in SCCs of the anal region. |
### Instruction:
Is quality of lymphadenectomy equivalent with robotic and open cystectomy using an extended template?
### Response:
| No difference was identified in the lymph node yield or the positive node rate when comparing open and robotic extended lymph node dissection. Local recurrence and survival data are needed to confirm whether the 2 techniques are oncologically equivalent. |
### Instruction:
Does isoflurane enhance both fast and slow synaptic inhibition in the hippocampus at amnestic concentrations?
### Response:
| Isoflurane enhances both types of phasic GABA A receptor-mediated inhibition to similar degrees at amnesic concentrations. This pattern differs from etomidate, which at low concentrations selectively enhances slow inhibition. These effects of isoflurane are sufficiently large that they may contribute substantially to its suppression of hippocampal learning and memory. |
### Instruction:
Is spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats?
### Response:
| The present study shows that inhibition of spinal mTOR blocks cancer-related pain without affecting acute pain and locomotor function. Given that mTOR inhibitors are FDA-approved drugs, mTOR in spinal cord may represent a potential new target for preventing and/or treating cancer-related pain. |
### Instruction:
Does a panel of four miRNAs accurately differentiate malignant from benign indeterminate thyroid lesions on fine needle aspiration?
### Response:
| This study shows that that the expression of miR-222, miR-328, miR-197, and miR-21 combined in a predictive model is accurate at differentiating malignant from benign indeterminate thyroid lesions on FNA. These findings suggest that FNA miRNA analysis could be a useful adjunct in the management algorithm of patients with thyroid nodules. |
### Instruction:
Does use of xanthine oxidase inhibitor febuxostat inhibit renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy?
### Response:
| Our results provide evidence for the renoprotective action of febuxostat against the formation of interstitial fibrosis. A decrease in macrophage infiltration and interstitial fibrosis, along with a decrease of the oxidative stress marker, strongly suggests the existence of a causal relationship between them. Febuxostat may have therapeutic value in slowing or preventing interstitial fibrosis in patients with CKD. |
### Instruction:
Is the impairment of reproduction in db/db mice mediated by intraovarian defective leptin signaling?
### Response:
| We confirmed that impairment of reproduction in intact db/db mice is not mediated by intraovary intact/defective leptin signaling even in face of a divergent modulation by gonadotropins. |
### Instruction:
Is minimal residual disease quantification an independent predictor of progression-free and overall survival in chronic lymphocytic leukemia : a multivariate analysis from the randomized GCLLSG CLL8 trial?
### Response:
| MRD levels independently predict OS and PFS in CLL. Therefore, MRD quantification might serve as a surrogate marker to assess treatment efficacy in randomized trials before clinical end points can be evaluated. |
### Instruction:
Does alcohol consumption show a J-shaped association with lower urinary tract symptoms in the general screening population?
### Response:
| To the best of our knowledge this is the largest population based study to evaluate the relationship between alcohol consumption and moderate to severe lower urinary tract symptoms, including voiding and storage symptoms. In men alcohol consumption shows a J-shaped curve relationship with the risk of moderate to severe lower urinary tract symptoms. |
### Instruction:
Is body weight perception associated with socio-economic status and current body weight in selected urban and rural South Indian school-going children?
### Response:
| SES is associated with body weight perception. Underweight children are more likely to overestimate their weight status and overweight children more likely to underestimate it. |
### Instruction:
Does age-related accumulation of T cells with markers of relatively stronger autoreactivity lead to functional erosion of T cells?
### Response:
| These findings suggest that age-associated dysfunctions of the immune system could in part be due to functional erosion of T cells devised to protect the hosts from the prolonged exposure to T cells with high-avidity for self. |
### Instruction:
Does anesthetic propofol cause glycogen synthase kinase-3β-regulated lysosomal/mitochondrial apoptosis in macrophages?
### Response:
| These results suggest an essential role of GSK-3β in propofol-induced lysosomal/mitochondrial apoptosis. |
### Instruction:
Do complement and UV-irradiated photoreceptor outer segments increase the cytokine secretion by retinal pigment epithelial cells?
### Response:
| RPE cultivation with UV-POS might serve as a model to investigate the accumulation of lipofuscin-like structures. The enhanced cytokine secretion due to UV-POS with HCS may account for an increased susceptibility for lipofuscin-loaded cells to complement, inducing a proinflammatory environment as observed in AMD. |
### Instruction:
Is a novel polymorphism of the CYP4A11 gene associated with coronary artery disease?
### Response:
| rs3890011 maybe a novel polymorphism of the CYP4A11 gene associated with CAD in a Han Chinese population. |
### Instruction:
Is hMOX1 promoter ( GT ) n polymorphim associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population?
### Response:
| The distribution pattern of HMOX1 (GT) alleles was different in the Mexican population than those reported elsewhere. Our results suggest that HMOX1 (GT)n polymorphism was associated with susceptibility to childhood-onset SLE but not with JRA in Mexican individuals. |
### Instruction:
Does the cold-induced basic helix-loop-helix transcription factor gene MdCIbHLH1 encode an ICE-like protein in apple?
### Response:
| Based on these findings, MdCIbHLH1 encodes a transcription factor that is important for the cold tolerance response in apple. |
### Instruction:
Does pulsed light irradiation improve behavioral outcome in a rat model of chronic mild stress?
### Response:
| TLT was comparable to fluoxetine in improving the behavioral outcome after CMS. TLT did not cause weight loss, which is consistently seen in patients treated with fluoxetine. This study demonstrates that TLT has potential as an effective treatment for depression. |
### Instruction:
Does [ Resveratrol improve coronary collateral circulation in pigs with experimental acute coronary occlusion ]?
### Response:
| The collateral circulation after acute coronary occlusion was obviously insufficient in pigs. Resveratrol could significantly improve the blood flow in coronary collateral circulation after acute occlusion in this model. |
### Instruction:
Does raloxifene inhibit menin-dependent estrogen receptor activation in breast cancer cells?
### Response:
| Raloxifene inhibits the binding of menin to the AF-2 domain of ERα, suggesting that raloxifene is one of the therapeutic options for menin-positive breast cancer. |
### Instruction:
Is miRNA-141 a novel regulator of BMP-2-mediated calcification in aortic stenosis?
### Response:
| We report a completely novel role of miRNA-141 as a regulator of BMP-2-dependent aortic valvular calcification and demonstrate marked attenuation of miRNA-141 expression in patients with bicuspid aortic valve-associated aortic stenosis. Therapeutic targeting of miRNA-141 could serve as a novel strategy to limit progressive calcification in aortic stenosis. |
### Instruction:
Is over-expression of a cytochrome P450 associated with resistance to pyriproxyfen in the greenhouse whitefly Trialeurodes vaporariorum?
### Response:
| Over-expression of a single cytochrome P450 gene (CYP4G61) has emerged as a strong candidate for causing the enhanced resistance phenotype. Further work is needed to confirm the role of the encoded P450 enzyme CYP4G61 in detoxifying pyriproxyfen. |
### Instruction:
Is androgen-deprivation therapy for nonmetastatic prostate cancer associated with an increased risk of peripheral arterial disease and venous thromboembolism?
### Response:
| GnRH agonist use was associated with an increased risk of incident PAD (adjusted hazard ratio [HR]: 1.16; 95% confidence interval [CI], 1.12-1.21) and incident venous thromboembolism (adjusted HR: 1.10; 95% CI, 1.04-1.15). In addition, orchiectomy was associated with an increased risk of peripheral arterial disease (adjusted HR: 1.13; 95% CI, 1.02-1.26) and venous thromboembolism (adjusted HR: 1.27; 95% CI, 1.11-1.45). Limitations include the observational study design and the inability to assess the use of oral antiandrogens. |
### Instruction:
Does n-3 polyunsaturated fatty acid supplementation reduce vulnerability to atrial fibrillation in remodeling atria?
### Response:
| PUFA supplementation begun after cardiac injury has already occurred does not reduce atrial structural remodeling or vulnerability to AF. |
### Instruction:
Is a common variant near the KCNJ2 gene associated with T-peak to T-end interval?
### Response:
| The common variant rs7219669 is associated with the TPE interval and is thus a candidate to modify repolarization-related arrhythmia susceptibility in individuals carrying the major allele of this polymorphism. |
### Instruction:
Is iL28B polymorphism associated with fatty change in the liver of chronic hepatitis C patients?
### Response:
| In this study, a new quantitative method to objectively evaluate hepatic steatosis was described. IL28B genotypes were significantly associated with both vesicular and clear cell changes of livers in chronic hepatitis C patients. |
### Instruction:
Does isoflurane induce cognitive deficits in the Morris water maze task in rats?
### Response:
| Isoflurane exposure impaired retention memory for platform location 1 week after exposure in young adult rats and resulted in a delayed although weak impairment at 4 weeks in middle-aged rats. The great variation in reported effects of isoflurane suggests a complex effect of this agent on memory which warrants further investigation. |
### Instruction:
Are self-reported empathy deficits uniquely associated with poor functioning in schizophrenia?
### Response:
| Impaired perspective-taking, a component of cognitive empathy, is associated with poor functioning even after taking into account the influences of neurocognitive deficits and psychopathology. These findings support further efforts to clarify the underlying causes of empathic disturbances and suggest that treatments for these disturbances may help functional recovery in schizophrenia. |
### Instruction:
Do [ Effect of paternity leave on maternal postpartum depression ]?
### Response:
| It is not the presence of the father wich seems important to take into account for detection and the traitement of postpatum depression but his participation in the care of the baby. |
### Instruction:
Does socioeconomic disadvantage increase risk of prevalent and persistent depression in later life?
### Response:
| The higher prevalence and persistence of depression amongst disadvantaged older adults cannot be easily explained by confounding. Management of depression in disadvantaged areas may need to extend beyond traditional medical and psychological approaches. |
### Instruction:
Does exercise training enhance cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats?
### Response:
| Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways, which provides one of the new beneficial effects for exercise training in diabetes. |
### Instruction:
Is macrocytosis a predictor of resting lactate concentrations in persons on dideoxynucleoside therapy for HIV infection?
### Response:
| Macrocytosis may be a marker of treatment-related mitochondrial dysfunction in persons on treatment for HIV. Evaluating patients for early evidence of mitochondrial dysfunction in resource-constrained settings could be facilitated by this marker. |
### Instruction:
Do cytokine and chemokine responses to Japanese encephalitis live attenuated vaccine in a human population?
### Response:
| IL-6, IL-8, MCP-1, MIP-1α, and MIP-1β may play important roles in the immune response to JE live attenuated vaccine. |
### Instruction:
Does ligustrazine attenuate acute lung injury induced by blunt chest trauma?
### Response:
| Ligustrazine effectively protects lung injury induced by blunt chest trauma, and the protective effects seem to be mediated by attenuation of cell apoptosis via an increased ratio of Bcl-2/Bax and decreased caspase-3 activity. |
### Instruction:
Does heart rate variability biofeedback decrease blood pressure in prehypertensive subjects by improving autonomic function and baroreflex?
### Response:
| These effects suggest that HRV-BF, a novel behavioral neurocardiac intervention, could enhance BRS, improve the cardiac autonomic tone, and facilitate BP adjustment for individuals with prehypertension. |
### Instruction:
Does cancer stem cell phenotype relate to radio-chemotherapy outcome in locally advanced squamous cell head-neck cancer?
### Response:
| CSC markers are linked with poor radiotherapy outcome in HNSCC, with integrin-β1 being the strongest and independent prognostic factor. Targeting CSC molecules with monoclonal antibodies or pharmaceutical agents may prove important for the treatment of HNSCC. |
### Instruction:
Does enzastaurin have anti-tumour effects in lung cancers with overexpressed JAK pathway molecules?
### Response:
| Our results suggested that the JAK1 pathway may be used as a single predictive biomarker for enzastaurin treatment. The anti-tumour effect of enzastaurin should be evaluated in lung cancer with overexpressed JAK pathway molecules. |
### Instruction:
Is regurgitation less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease?
### Response:
| Regurgitation was less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease, indicating that persistent regurgitation is a common cause of incomplete treatment response. |
### Instruction:
Is use of a Pfannenstiel incision in minimally invasive colorectal cancer surgery associated with a lower risk of wound complications?
### Response:
| The use of a Pfannenstiel incision in MIS colorectal cancer resections is associated with a decreased risk of short-term wound complications. |
### Instruction:
Does family history predict angiographic localization or severity of coronary artery disease?
### Response:
| Sex-specific family history data do not predict angiographic localization of coronary disease in patients presenting with ACS. Maternal stroke and maternal MI probably affect ACS in females by a mechanism unrelated to atherosclerosis or coronary anatomy. However, family history data may still be useful in risk prediction and prognosis of ACS. |
### Instruction:
Does grape juice concentrate modulate p16 expression in high fat diet-induced liver steatosis in Wistar rats?
### Response:
| Taken together, our results suggest that subchronic grape juice concentrate administration was able to modulate cell cycle control by downregulation of p16 immunoexpression in high fat diet-induced liver steatosis in rats. |
### Instruction:
Is nT-proBNP associated with fibulin-1 in Africans : the SAfrEIC study?
### Response:
| Only Africans indicated a significant independent association between NT-proBNP and fibulin-1, suggesting that cardiovascular alterations are already present in this relatively young African population as opposed to Caucasians. |
### Instruction:
Is epiphany root canal sealer prepared with resinous solvent irritating to rat subcutaneous tissues?
### Response:
| The Epiphany sealer prepared with the RS was irritating to rat subcutaneous tissues. |
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