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### Instruction:
Is human dental pulp stem cell a promising autologous seed cell for bone tissue engineering?
### Response:
| These findings suggested that hDPSCs may be valuable as seed cells for bone tissue engineering. As a special stem cell source, hDPSCs may blaze a new path for bone tissue engineering. |
### Instruction:
Does obesity alter the expression profile of clock genes in peripheral blood mononuclear cells?
### Response:
| Differences were observed in the expression profile variation of clock genes between the obese and non-obese groups. This study reveals the differences in clock gene expression profiles between obese and non-obese subjects, with evidence for two distinct chronotypes, and suggests a contribution of these chronotypes to fat accumulation in humans. |
### Instruction:
Do sendai virus-based liposomes enable targeted cytosolic delivery of nanoparticles in brain tumor-derived cells?
### Response:
| These findings are the first to utilize the Sendai virus to achieve cytosolic, targeted intracellular binding of Qdots within Human brain tumor cells. The results are significant to the continued applicability of nanoparticles used for the molecular labeling of cancer cells to determine tumor heterogeneity, grade, and chemotherapeutic resistivity. |
### Instruction:
Is a clinically confirmed family history for early myocardial infarction associated with increased risk of obesity , insulin resistance and metabolic syndrome?
### Response:
| Parental history of clinically verified early MI is associated with MetS, obesity and insulin resistance rather than with traditional cardiovascular disease risk factors such as LDL and smoking, suggesting that primary preventive interventions targeted at weight reduction and improvement of insulin sensitivity may be particularly beneficial in this subset of the population. |
### Instruction:
Do diverse sensory inputs permit priming in the acidic saline model of hyperalgesia?
### Response:
| These data indicate that anatomically diverse peripheral stimuli can converge within the central nervous system to produce hyperalgesia. |
### Instruction:
Is multiple sclerosis fatigue associated with reduced psychomotor vigilance?
### Response:
| Subjective fatigue and disability were associated with poor performance on alertness testing in MS patients. This research highlights a potential role for psychomotor vigilance testing in providing a standardized assessment tool for an important aspect of MS-related fatigue. |
### Instruction:
Does a novel PLP1 mutation further expand the clinical heterogeneity at the locus?
### Response:
| We report a new PLP1 gene mutation in a patient with a clinical phenotype consistent with a PLP1 null syndrome. |
### Instruction:
Does the validity of heart failure diagnoses obtained from administrative register?
### Response:
| Classification obtained from administrative registers has high specificity and can be used in follow-up studies with HF as an end point. Sensitivity is modest and administrative data should be used with caution for surveillance. |
### Instruction:
Does antagonistic experimental coevolution with a parasite increase host recombination frequency?
### Response:
| This study provides direct, experimental evidence for an increase in recombination frequency under host-parasite coevolution in an obligatory outcrossing species. Combined with earlier results, the Red Queen process is the most likely explanation for this observation. |
### Instruction:
Are systemic soluble tumor necrosis factor receptors 1 and 2 associated with severity of diabetic retinopathy in Hispanics?
### Response:
| Levels of sTNF-R1 and sTNF-R2 are highly correlated with the severity of DR, suggesting that inflammation and insulin resistance may play a critical role in the development of DR. These may be useful biomarkers for DR, aiding in etiologic studies and possibly identifying at-risk patients for active intervention. |
### Instruction:
Does generalized anxiety modulate frontal and limbic activation in major depression?
### Response:
| Our findings highlight frontal and limbic hypoactivation in patients with depression and comorbid anxiety and indicate that anxiety level may modulate frontal and limbic activation depending upon the emotional context. One implication of this finding is that divergent findings reported in the imaging literature on depression could reflect modulation of activation by anxiety level in response to different types of emotional information. |
### Instruction:
Is normalization of visceral adiposity required to normalize plasma apolipoprotein B levels in response to a healthy eating/physical activity lifestyle modification program in viscerally obese men?
### Response:
| These results suggest that, in order to "normalize" apoB levels in response to a lifestyle modification program, viscerally obese dyslipidemic men need to achieve levels of VAT similar to healthy non-obese men. |
### Instruction:
Do discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices?
### Response:
| Our results suggest a mechanism by which the presence of collagen I in situations of excessive matrix deposition could induce fibroblast migration through basement membranes through DDR2 activation and subsequent DDR1 and MMP-2 gene expression. This work provides new insights into the role of DDRs in fibroblast function. |
### Instruction:
Is younger gestational age associated with worse neurodevelopmental outcomes after cardiac surgery in infancy?
### Response:
| These findings are consistent with the hypothesis that delivery before 39 to 40 weeks of GA is associated with worse outcomes in patients with CHD. Early delivery of a child with CHD is often indicated because of maternal or fetal health issues. In the absence of these concerns, these data suggest that elective (or spontaneous) delivery at 39 to 40 weeks of GA is associated with better ND outcomes. |
### Instruction:
Does treatment with tPA predict better outcome even if MCA occlusion persists?
### Response:
| Although the prognosis of patients with persisting middle cerebral artery occlusion after tissue plasminogen activator administration is known to be poor, patients do better if treated with tissue plasminogen activator vs. those who could not be treated - mainly for late presentation. This may be due to sufficient small vascular territory recanalization despite persistence of large artery occlusion after tissue plasminogen activator treatment. |
### Instruction:
Does basic self-disturbance predict psychosis onset in the ultra high risk for psychosis `` prodromal '' population?
### Response:
| The results indicate that identifying basic self-disturbance in the UHR population may provide a means of further "closing in" on individuals truly at high risk of psychotic disorder, particularly of schizophrenia spectrum disorders. This may be of practical value by reducing inclusion of "false positive" cases in UHR samples and of theoretical value by shedding light on core phenotypic features of schizophrenia spectrum pathology. |
### Instruction:
Does beta blocker use in subjects with type 2 diabetes mellitus and systolic heart failure worsen glycaemic control?
### Response:
| BB use did not worsen glycaemic control, lipid profile or albuminuria status in subjects with SHF and T2DM. Carvedilol significantly improved glycemic control in subjects with SHF and T2DM and this improvement was non significantly better than that obtained with bisoprolol. BB's should not be withheld from patients with T2DM and SHF. |
### Instruction:
Do carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients?
### Response:
| Carrier-bound Der p 2 peptides should allow avoiding IgE-mediated side-effects, and because of their low potential to activate allergen-specific T cells, they may reduce late-phase side-effects during SIT. Further, these peptides may be also useful for prophylactic vaccination. |
### Instruction:
Is expression of receptor for advanced glycation end products ( RAGE ) on the surface of circulating endothelial cells upregulated in Kawasaki disease?
### Response:
| The results suggest that the expression levels of RAGE on the surface of CECs are upregulated in KD patients, and that the upregulated expression levels of RAGE on the surface of CECs can be aggravated in SA-KD and C-KD patients with CALs, and also in IVIG-resistant SA-KD and C-KD patients. The RAGE expression on CECs is involved in the pathophysiology of KD. |
### Instruction:
Does rye bread intake improve oxidation resistance of LDL in healthy humans?
### Response:
| Rye bread intake improved significantly the oxidation resistance of LDL. Further studies are needed to clarify the protective mechanism(s). |
### Instruction:
Is a major imprinted gene involved in hydatidiform mole located in 2q31.2-qter or 5q34-qter?
### Response:
| If the molar phenotype is caused by paternal excess of one gene, only, it is unlikely that this gene is located telomeric to genome position 179Mb on chromosome 2. And similarly, if the phenotype complete mole is caused by the presence of exclusively paternally imprinted alleles of one gene, this gene is not located telomeric to genome position 165Mb on chromosome 5. |
### Instruction:
Is iL-10 transcription negatively regulated by BAF180 , a component of the SWI/SNF chromatin remodeling enzyme?
### Response:
| These results demonstrate that BAF180 is a repressor of IL-10 transcription in Th2 cells and suggest that the differential recruitment of different SWI/SNF subtypes can have direct consequences on chromatin structure and gene transcription. |
### Instruction:
Are fibrillation potentials of denervated rat skeletal muscle associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5?
### Response:
| Expression of Nav1.5 participates in the generation of fibrillation potentials in denervated rat skeletal muscle. |
### Instruction:
Is geographical variation in ambulance calls associated with socioeconomic status?
### Response:
| This study demonstrates the utility of geospatial analysis to relate population socioeconomic factors with ambulance call volumes. This can serve as a model for analysis of other public health systems. |
### Instruction:
Does proton pump inhibitor therapy use predispose to small intestinal bacterial overgrowth?
### Response:
| In this large, adequately powered equivalence study, PPI use was not found to be significantly associated with the presence of SIBO as determined by the GHBT. |
### Instruction:
Do [ The clinical study of high-frequency ultrasound-guided vacuum-assisted biopsy for breast microcalcifications ]?
### Response:
| The clinical application of high-frequency ultrasound-guided vacuum-assisted biopsy was an effective option for the diagnosis of breast microcalcifications, especially for the type of microcalcifications with masses and the maximal diameter more than 5 mm. |
### Instruction:
Does automated data extraction -- a feasible way to construct patient register of primary care utilization?
### Response:
| The CXP is a reliable and accurate data mining tool to extract selective data from EMR. |
### Instruction:
Does nDRG2 promote GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells?
### Response:
| The results reveal that NDRG2 promotes the expression of GATA-1 through activation of the JAK2/STAT pathway, but not through the regulation of the BMP-4/Smad pathway in U937 cells. Our findings further suggest that NDRG2 may play a role as a regulator of erythrocyte and megakaryocyte differentiation during hematopoiesis. |
### Instruction:
Is production of prostaglandin e ( 2 ) and i ( 2 ) coupled with cyclooxygenase-2 in human follicular dendritic cells?
### Response:
| The current results suggest that mPGES-1 and PGIS are coupled with COX-2 but not with COX-1 in human follicular dendritic cell (FDC) and may help understand the potential effects of selective COX inhibitors on the humoral immunity. |
### Instruction:
Does hydrogen gas ameliorate oxidative stress in early brain injury after subarachnoid hemorrhage in rats?
### Response:
| Hydrogen gas could exert its neuroprotective effect against early brain injury after subarachnoid hemorrhage by its antioxidative activity. |
### Instruction:
Does systemic administration of autologous adipose-derived mesenchymal stem cells alleviate hepatic ischemia-reperfusion injury in rats?
### Response:
| The results showed that systemic adipose tissue-derived mesenchymal stem cell administration significantly preserved hepatocyte integrity and suppressed inflammatory responses, oxidative stress, and apoptosis in a rodent model of hepatic ischemia-reperfusion injury. |
### Instruction:
Does up-regulation of microRNA-21 correlate with lower kidney cancer survival?
### Response:
| The current study shows a clear correlation between miR-21 expression and clinical characteristics of renal cancer. Thus we believe that miR-21 can be used as a tumor marker and its inhibition may prove to be useful in controlling cancers with up-regulated miR-21. |
### Instruction:
Does ubiquitin-specific protease 4 inhibit mono-ubiquitination of the master growth factor signaling kinase PDK1?
### Response:
| The regulated mono-ubiquitination of PDK1 provides an unanticipated layer of complexity in this central signaling network and offers potential novel avenues for drug discovery. |
### Instruction:
Does fGD5 mediate proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells?
### Response:
| This study provides the first demonstration of expression, subcellular localization, and function of FGD5 in vascular ECs. The results suggest that FGD5 regulates proangiogenic action of VEGF in vascular ECs, including network formation, permeability, directional movement, and proliferation. |
### Instruction:
Do creatinine and insulin predict cardiac mass in drug-naïve hypertensive patients?
### Response:
| Independently of other risk factors, fasting insulin and serum creatinine contribute to explain LVM development in hypertensives with preserved renal function; insulin interacts with creatinine in explaining LVM variability in these patients. |
### Instruction:
Does curcumin protect against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain?
### Response:
| These data suggest that CUR may be an alternative to prevent neurodegenerative damage after pesticide exposure. |
### Instruction:
Does actin cytoskeleton rest stop regulate anterograde traffic of connexin 43 vesicles to the plasma membrane?
### Response:
| Actin is a necessary component of the cytoskeleton-based forward trafficking apparatus for Cx43. In cardiomyocytes, Cx43 vesicles spend a majority of their time pausing at nonsarcomeric actin rest stops when not undergoing microtubule-based transport to the plasma membrane. Deleterious effects on this interaction between Cx43 and the actin cytoskeleton during acute ischemia contribute to losses in Cx43 localization at intercalated discs. |
### Instruction:
Does green tea polyphenol epigallocatechin-3-gallate show therapeutic antioxidative effects in a murine model of colitis?
### Response:
| These data support the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis, an effect that may be mediated by its strong antioxidative potential. |
### Instruction:
Do obesity-related systemic factors promote an invasive phenotype in prostate cancer cells?
### Response:
| We report, prostate cancer cells exposed to sera from obese mice increases proliferation, invasion, migration, MMP activity and induces changes in proteins critical for EMT. |
### Instruction:
Does hypoxia-inducible factor 1 mediate nasal polypogenesis by inducing epithelial-to-mesenchymal transition?
### Response:
| hNECs undergo EMT during hypoxia and this process is critically mediated by HIF-1α and pSmad3. This study shows that hypoxia-induced EMT is likely to contribute to nasal polyposis in CRS, and suggests that HIF-1α be viewed as a therapeutic target for nasal polyposis. |
### Instruction:
Is dNA hypomethylation at ALOX12 associated with persistent wheezing in childhood?
### Response:
| DNA methylation of ALOX12 may be an epigenetic biomarker for the risk of asthma-related phenotypes. |
### Instruction:
Do vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans?
### Response:
| Autophagy protects against infection with H pylori; the toxin VacA disrupts autophagy to promote infection, which could contribute to inflammation and eventual carcinogenesis. |
### Instruction:
Are current self-reported symptoms of attention deficit/hyperactivity disorder associated with total brain volume in healthy adults?
### Response:
| This finding improves our understanding of the biological substrates of self-reported ADHD symptoms, and suggests total brain volume as a target intermediate phenotype for future gene-finding in ADHD. |
### Instruction:
Does targeting Gene-Viro-Therapy with AFP driving Apoptin gene show potent antitumor effect in hepatocarcinoma?
### Response:
| The AD55-Apoptin can be a potential anti-hepatoma agent with remarkable antitumor efficacy as well as higher safety in cancer targeting gene-viro-therapy system. |
### Instruction:
Is cognitive dysfunction worse among pediatric patients with bipolar disorder Type I than Type II?
### Response:
| Findings from the current study indicate that BD I patients are characterized by more severe cognitive impairment relative to BD II patients who show an intermediate pattern of performance between BD I patients and HC. Verbal learning and memory may effectively differentiate pediatric BD patients and controls, regardless of the subtype of BD, and may serve as a cognitive endophenotype for the disorder. Additionally, these findings move us closer to developing effective cognitive interventions tailored to specific subtypes of pediatric BD patients. |
### Instruction:
Does obesity play an independent worsening modifying effect on nocturnal hypoxia in obstructive sleep apnea?
### Response:
| Our results indicate that obesity plays an independent worsening modifying effect on nocturnal hypoxia in OSAS. |
### Instruction:
Do spinal bombesin-recognized neurones mediate more nonhistaminergic than histaminergic sensation of itch in mice?
### Response:
| These results suggest that spinal bombesin-recognized neurones are critical to both the histamine-dependent and histamine-independent pathways for itch, and that they mediate more nonhistaminergic than histaminergic sensation of itch in mice. |
### Instruction:
Does low high-density lipoprotein 3 reduce the odds of men surviving to age 85 during 53-year follow-up?
### Response:
| Low HDL3 reduces the odds of extended survival in men, independent of HDL2, other lipoproteins, and standard risk factors. |
### Instruction:
Are mitochondrial fission proteins in peripheral blood lymphocytes potential biomarkers for Alzheimer 's disease?
### Response:
| Altered mitochondrial fission proteins Drp1, SNO-Drp1, and Fis1 in PBL were relatively sensitive and specific in identifying AD patients and could be serving as a biomarker in the procedure of diagnosis. |
### Instruction:
Does elevated interleukin-8 enhance prefrontal synaptic transmission in mice with persistent inflammatory pain?
### Response:
| Our findings suggest that up-regulation of IL-8 in the ACC partly attributable to the enhanced prefrontal synaptic transmission in the mice with persistent inflammatory pain. |
### Instruction:
Is carbonic anhydrase IX a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification?
### Response:
| We demonstrate that CA IX expression is correlated with worse PFS and OS for breast cancer patients treated with doxorubicin, independent of HER2 or TOP2A gene amplification. This study provides evidence that using CA IX to detect hypoxia in surgically-resected breast tumours may be of clinical use in choosing an appropriate chemotherapy regimen. |
### Instruction:
Does admission glucose improve GRACE score at 6 months and 5 years after myocardial infarction?
### Response:
| APG is a predictor of 6-month and 5-year mortality, each mmol/l increase in APG being associated with a mortality increase of 17 and 12%, respectively, independent of the GRACE risk score. However, adding APG to the GRACE model did not result in significantly improved clinical risk stratification. |
### Instruction:
Does intracerebroventricular administration of metformin inhibit ghrelin-induced Hypothalamic AMP-kinase signalling and food intake?
### Response:
| Metformin could reduce food intake by preventing ghrelin-induced AMPK signalling and mTOR inhibition in the hypotalamus. |
### Instruction:
Is leukocyte-depleted blood transfusion associated with decreased survival in resected early-stage lung cancer?
### Response:
| Our data suggest that transfusion of LD blood is associated with a worse disease-free and overall survival in patients with resected stage I non-small cell lung cancer. |
### Instruction:
Does integrated approach to functionally characterize novel factors in lipoprotein metabolism?
### Response:
| The integration of GWAS data with existing functional genomics strategies has contributed to ascertain the relevance of a number of novel factors for lipoprotein biology and disease. However, technologies are warranted that provide a more systematic insight into the molecular function and pathogenic relevance of promising candidate genes. |
### Instruction:
Does serological investigation of pneumonia as it present to the physician 's office?
### Response:
| While it is not possible to generalize about these findings because of ascertainment bias, the data suggest that M pneumoniae is a common cause of pneumonia presenting to a physician's office and that mortality is low in this group of patients. |
### Instruction:
Is genetic variability in adapter proteins with APPL1/2 associated with the risk of coronary artery disease in type 2 diabetes mellitus in Chinese Han population?
### Response:
| Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population. |
### Instruction:
Is high-normal serum uric acid associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients?
### Response:
| High-normal SUA was associated with albuminuria and impaired glomerular filtration rate in Chinese type 2 diabetic patients. |
### Instruction:
Is lipopolysaccharide-enhanced early proliferation of insulin secreting NIT-1 cell associated with nuclear factor-kappaB- mediated inhibition of caspase 3 cleavage?
### Response:
| LPS promotes early NIT-1 cell proliferation in association with NF-κB-mediated inhibition of caspase 3 cleavage. LPS exerts a time-dependent inhibitory effect on chronic insulin secretion from NIT-1 cells. |
### Instruction:
Is cytokine BAFF gene variation associated with survival of patients with T-cell lymphomas?
### Response:
| These findings suggest that functional polymorphism in BAFF might be a genetic determinant for the survival of patients with TCL. |
### Instruction:
Does free-radical scavenger edaravone inhibit both formation and development of abdominal aortic aneurysm in rats?
### Response:
| Edaravone inhibition of ROS can prevent aneurysm formation and expansion in the rat AAA model. Free-radical scavenger edaravone might be an effective pharmaceutical agent for AAA in clinical practice. |
### Instruction:
Is sNP rs356219 of the α-synuclein ( SNCA ) gene associated with Parkinson 's disease in a Chinese Han population?
### Response:
| The results suggested that SNCA rs356219 variant might have an increased risk of susceptibility to PD in a Chinese Han population. Further studies are needed to replicate the association that we found. |
### Instruction:
Are chromosome 9p21 single nucleotide polymorphisms associated with recurrent myocardial infarction in patients with established coronary artery disease?
### Response:
| 9p21 SNPs were not associated with recurrent MI, revascularization, or mortality after ACS or CABG. Individuals with the rs1333049 C allele, however, may present with earlier and more extensive disease. |
### Instruction:
Does [ Intermediate result on the use of drainage devices for paediatric glaucoma ]?
### Response:
| GDDs are a good surgery option for refractory paediatric glaucoma when other surgery procedures have failed or have bad prognosti. |
### Instruction:
Do transplantation of Cbfa1-overexpressing adipose stem cells together with vascularized periosteal flaps repair segmental bone defects?
### Response:
| Combination with implanting the Cbfa1 gene-modified tissue-engineered bone and vascularized periosteum can better repair the segmental bone defects by stimulating osteogenesis, osteoinduction, and osteoconduction than using either one of the approaches. |
### Instruction:
Is the tyrosyl-tRNA synthetase like gene located in the tyramine biosynthesis cluster of Enterococcus durans transcriptionally regulated by tyrosine concentration and extracellular pH?
### Response:
| The expression of the tyrS gene present in the TDC cluster of E. durans is transcriptionally regulated by tyrosine concentration and extracelular pH. The regulation is mediated by both an antitermination system and the promoter itself. |
### Instruction:
Does antinociceptive activity of acute and chronic administration of Murraya koenigii L. leave in experimental animal models?
### Response:
| The degree of antinociception produced by PMK and AMK at the end of 15 days study suggest that Murraya koenigii has potential to use as an analgesic. |
### Instruction:
Does microbubble therapy enhance anti-tumor properties of cisplatin and cetuximab in vitro and in vivo?
### Response:
| MB-UST promotes disruption of cell membranes in tumor cells in vitro, which may be leveraged to selectively improve the uptake of conventional and targeted therapeutics in vivo. |
### Instruction:
Are genetic polymorphisms of FcγRIIa and FcγRIIIa predictive of clinical outcomes after cetuximab plus irinotecan chemotherapy in patients with metastatic colorectal cancer?
### Response:
| The FcγRIIa and FcγRIIIa polymorphisms may not be useful molecular biomarkers for the activity of cetuximab in patients with mCRC. |
### Instruction:
Does curative treatment with extracts of Bombax ceiba fruit reduce risk of calcium oxalate urolithiasis in rats?
### Response:
| The results indicate that the fruit of B. ceiba is endowed with lithontriptic activity warranting further development for curative treatment of urolithiasis. |
### Instruction:
Is role of C6ORF120 , an N-glycosylated protein , implicated in apoptosis of CD4⁺ T lymphocytes?
### Response:
| Our results suggested that C6ORF120 could induce apoptosis of CD4(+) T cells, at least in part, mediated with endoplasmic reticulum stress. |
### Instruction:
Does astrocyte elevated gene-1 induce breast cancer proliferation and invasion through upregulating HER2/neu expression?
### Response:
| AEG-1 might facilitate the proliferation and invasion of breast cancer cells by upregulating HER2/neu expression, which provides a potential target for breast cancer therapy. |
### Instruction:
Does apigenin accelerate lipopolysaccharide induced apoptosis in mesenchymal stem cells through suppressing vitamin D receptor expression?
### Response:
| API could inhibit the expression of inducible inflammatory factors, therefore exert the strong anti-inflammatory function. However, API could not protect MSC apoptosis induced by LPS but amplified the apoptosis. The apoptosis is related to Bad/Bcl-2 increasing and caspase-3 activation, which is mediated through suppressing VDR expression. |
### Instruction:
Does rebamipide increase the mucin-like glycoprotein production in corneal epithelial cells?
### Response:
| Rebamipide promoted glycoconjugate, which has a property as a mucin-like glycoprotein, in human corneal epithelial cells. The increased production was mediated by MUC1 and MUC4 gene expression. |
### Instruction:
Is c-reactive protein a more sensitive and specific marker for diagnosing bacterial infections in systemic lupus erythematosus compared to S100A8/A9 and procalcitonin?
### Response:
| Our data suggest that CRP is the most sensitive and specific marker for diagnosing bacterial infections in SLE. |
### Instruction:
Do ciprofloxacin or imipenem use correlates with resistance in Pseudomonas aeruginosa?
### Response:
| Ciprofloxacin use was directly associated with ciprofloxacin resistance, and imipenem use was directly associated with imipenem resistance in P aeruginosa. |
### Instruction:
Does preincisional administration of intravenous or subcutaneous infiltration of low-dose ketamine suppress postoperative pain after appendectomy?
### Response:
| A 0.5 mg/kg dose of ketamine given at approximately 15 minutes before surgery by the intravenous route provided analgesia for 24 hours after surgery in patients undergoing appendectomy. |
### Instruction:
Do anticoagulants affect matrix metalloproteinase 9 levels in blood samples of stroke patients and healthy controls?
### Response:
| Preanalytics plays a key role for determination of MMP-9. EDTA seems to be a valid anticoagulant for MMP-9 protein measurement. |
### Instruction:
Is extracorporeal shock wave therapy useful after arthroscopic rotator cuff repair?
### Response:
| This study failed to prove that ESWT stimulates rotator cuff healing after arthroscopic rotator cuff repair. Additional ESWT after rotator cuff repair could theoretically be advantageous, and it was proven to be safe in this study. |
### Instruction:
Is microalbuminuria an independent prognostic marker in patients with chronic heart failure?
### Response:
| Microalbuminuria is an independent prognostic marker in pts with chronic HF. Pts with microalbuminuria had a trend for lower LVEF. |
### Instruction:
Is the neutrophilic inflammatory phenotype associated with systemic inflammation in asthma?
### Response:
| Systemic inflammation is increased in patients with asthma with neutrophilic airway inflammation and associated with worse clinical outcomes. Systemic inflammation may contribute to the pathophysiology of neutrophilic asthma. |
### Instruction:
Is single nucleotide polymorphism in gene encoding transcription factor Prep1 associated with HIV-1-associated dementia?
### Response:
| These results support previous findings suggesting an important role for MCP-1 in the onset of HIV-1-associated neurocognitive disorders. |
### Instruction:
Does [ Glycosyl-phosphatidylinositol-anchored interleukin-2 expressed on tumor-derived exosomes induce anti-tumor immune response ]?
### Response:
| GPI-IL-2 gene-modified tumor cells can make the exosomes containing GPI-IL-2 with an increased anti-tumor effect. Our study provides a feasible approach for exosome-based tumor immunotherapy of bladder transitional cell tumors. |
### Instruction:
Do women derive less benefit from elective endovascular aneurysm repair than men?
### Response:
| Mortality for females undergoing elective EVAR is significantly greater than for males. It is also more hazardous. Colon ischemia, native arterial rupture, and type 1 endoleaks are more frequent. Elective endovascular aneurysm repair benefits men more than women. |
### Instruction:
Are aBO antibody titers predictive of hemolytic reactions due to plasma-incompatible platelet transfusions?
### Response:
| A critical anti-A or -B titer is not sufficient to predict the risk of hemolysis in patients receiving plasma-incompatible APs, although underreporting of reactions to the blood bank may limit the generalizability of this study. |
### Instruction:
Does cyclooxygenase-2 promoter polymorphism -899G/C is associate with hepatitis B-related liver cancer in a Chinese population of Gansu province?
### Response:
| COX-2 -899C genotype may increase the susceptibility of individuals to hepatitis B-related liver cancer in Gansu province, China. |
### Instruction:
Does needle electromyography predict outcome after lumbar epidural steroid injection?
### Response:
| NEE is an independent predictor of long-term pain relief after LESI for LSR. Abnormal NEE is predictive of better outcome than normal NEE. A regression equation including NEE and other independent predictors was predictive of pain and functional outcomes. |
### Instruction:
Do coincident posttraumatic stress disorder and depression predict alcohol abuse during and after deployment among Army National Guard soldiers?
### Response:
| Coincident depression and PTSD were predictive of developing peri-/post-deployment alcohol abuse, and thus may constitute an etiologic pathway through which deployment-related exposures increase the risk of alcohol-related problems. |
### Instruction:
Does nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlate with noninvasive measurements of endothelial function?
### Response:
| Acetylcholine vasodilator responses in human gluteal subcutaneous arterioles are NO synthase dependent and correlate with cardiac risk factors and in vivo measures of endothelial function. These data suggest subcutaneous arterioles offer an opportunity for translational studies of mechanisms of modulating NO bioavailability relevant to in vivo endothelial function measures. |
### Instruction:
Does inhibition of Bcl-2 enhance the efficacy of epirubicin chemotherapy in PC-3 prostate cancer cells?
### Response:
| These data suggested that inhibition of Bcl-2 expression combined with epirubicin may be an attractive therapeutic strategy in hormone-refractory prostate cancer. |
### Instruction:
Do intermittent hypoxia and isoniazid plus rifampicin affect hepatic ultrastructure in mice?
### Response:
| Chronic intermittent hypoxia and isoniazid plus rifampicin treatment lead to synergistic liver cell ultrastructural injury. |
### Instruction:
Does expression of ERCC1 protein in biopsy specimen predict survival in advanced ovarian cancer patients treated with platinum-based chemotherapy?
### Response:
| Our results revealed that ERCC1 protein expression could potentially be used to customize chemotherapy by defining subsets of patients who would benefit the least from platinum-based chemotherapy. |
### Instruction:
Is worsening severity of vitamin D deficiency associated with increased length of stay , surgical intensive care unit cost , and mortality rate in surgical intensive care unit patients?
### Response:
| In univariate analysis, severe and moderate vitamin D deficiency was related inversely to the length of stay in the surgical intensive care unit (r = .194; P = .001), related inversely to surgical intensive care unit treatment cost (r = .194; P = .001) and mortality (r = .125; P = .023), compared with the mild vitamin D-deficient group, after adjusting for age, sex, race, and comorbidities (myocardial infarctions, acute renal failure, and pneumonia); the length of stay, surgical intensive care unit cost, and mortality remained significantly associated with vitamin D deficiency. |
### Instruction:
Does increased expression of granulocyte colony-stimulating factor mediate mesenchymal stem cells recruitment after vascular injury?
### Response:
| Increased expression of G-CSF by injured arteries plays an essential role in contribution to recruitment and homing of MSCs to the site of the arterial lesion. |
### Instruction:
Is early survival after heart transplant in young infants lowest after failed single-ventricle palliation : a multi-institutional study?
### Response:
| Infant HT recipients with different pre-HT diagnoses have significantly different post-HT outcomes. HLHS infants with surgery have the lowest survival and their outcome is unchanged in the current era. |
### Instruction:
Is vascular function impaired early in the course of bipolar disorder?
### Response:
| The lack of clinically significant differences in vascular function in this young sample suggests any increased risk either occurs later in the course of illness or is largely due to behavioral risk factors, such as smoking, which was balanced between groups. Substantial insulin resistance is identifiable early in course of illness, perhaps secondary to treatment. |
### Instruction:
Is hazardous alcohol consumption a major factor in male premature mortality in a typical Russian city : prospective cohort study 2003-2009?
### Response:
| This prospective cohort study strengthens the evidence that hazardous alcohol consumption has been a major determinant of mortality among working age men in a typical Russian city. As such the similar findings of the previous case-control studies cannot be explained as artefacts of limitations of their design. As Russia struggles to raise life expectancy, which even in 2009 was only 62 years among men, control of hazardous drinking must remain a top public health priority. |
### Instruction:
Do psychological aspects affect quality of life in patients with oral squamous cell carcinomas?
### Response:
| Taken together, these findings emphasise the impact of psychological treatment at least on a significant number of head and neck cancer patients. |
### Instruction:
Do [ Eco-geographic landscapes of natural plague foci in China I. Eco-geographic landscapes of natural plague foci ]?
### Response:
| Scientific basis for Chinese natural plague foci classification was provided. |
### Instruction:
Does acute cigarette smoking reduce latencies on a Smoking Stroop test?
### Response:
| Smoking-related cues have distracting effects in smokers, and smoking reduces response latency, with no specific effect on attentional bias. The increase in response speed may contribute to a smoker's impression that abstinence hinders performance and that smoking reverses impairment. |
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