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### Instruction:
Do evaluation of a Veress needle for the fluid egress system of stifle arthroscopy in toy dog breeds?
### Response:
| The Veress needle method used in this study was useful to establish a fluid egress system and limit iatrogenic cartilage excoriations. This technique could become the method of choice for stifle arthroscopy, especially in smaller dogs. |
### Instruction:
Is helicobacter pylori infection high in paediatric nonulcer dyspepsia but not associated with specific gastrointestinal symptoms?
### Response:
| The prevalence of H. pylori infection was high in Brazilian children with nonulcer dyspepsia, but was not associated with specific signs and symptoms, except for nausea. |
### Instruction:
Does tGF-β Type I Receptor Kinase Inhibitor EW-7197 suppress Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition?
### Response:
| This study suggests that EW-7197 exhibits potential as a treatment for liver fibrosis because it inhibits HIF1α-induced TGF-β signaling. |
### Instruction:
Is endocan of the maternal placenta tissue increased in pre-eclampsia?
### Response:
| Endocan may play a role in the progression of pregnancy and has a potential to be a new marker for the detective of PE. |
### Instruction:
Do dopamine D1-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL?
### Response:
| Macrophages express D1-like receptors. The activation of the D1-like receptors significantly inhibits Ox-LDL-induced macrophage proliferation, possibly through the inhibition of the PI3K/Akt and MAPK/ERK signaling pathways. |
### Instruction:
Do colorectal cancer-derived microvesicles modulate differentiation of human monocytes to macrophages?
### Response:
| Macrophage activity (polarization status) may be regulated by contact with not only tumour cells but also with TMVs. Their final polarization status depends on the contact time, and probably on the vesicle "cargo", as signified by the distinct impact of TMVs which enabled the switching of MDM maturation to regulatory macrophages. |
### Instruction:
Do miR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells?
### Response:
| To our knowledge, this is the first study showing the significance of miR-20a and miR-20b regulating autophagy by targeting RB1CC1/FIP200. |
### Instruction:
Are iL-6 , IL-8 , IP-10 , MCP-1 and G-CSF significantly increased in cerebrospinal fluid but not in sera of patients with central neuropsychiatric lupus erythematosus?
### Response:
| In central NPSLE the production of IL-6, IL-8, IP-10, MCP-1 and G-CSF might take place in the central nervous system (CNS). These increased CSF cytokines/chemokines along with anti-P might have a prerequisite role in the pathogenesis of central NPSLE. |
### Instruction:
Does inhalation therapy with M1 inhibit experimental melanoma development and metastases in mice?
### Response:
| Altogether these data suggest M1 is an efficient candidate for melanoma therapy to be considered for future clinic studies as this study is the first supporting the idea that melanoma patients may benefit with the treatment. The treatment with M1 provides advantages considering the highly-diluted properties and a cost effective alternative to costly chemotherapeutic approaches with, if any, lower toxicity. |
### Instruction:
Do cD146+ mesenchymal stem cells display greater therapeutic potential than CD146- cells for treating collagen-induced arthritis in mice?
### Response:
| This study suggests that CD146(+) cells have greater potency than CD146(-) cells for cartilage protection and can suppress Th17 cell activation. These data suggest a potential therapeutic application for CD146(+) cells in treating inflammatory arthritis. |
### Instruction:
Do chromosomal disruption and rearrangements during murine sarcoma development converge to stable karyotypic formation kept by telomerase overexpression?
### Response:
| Our data reinforce the notion that the sarcoma cell evolution converges from a highly unstable karyotype to relatively stable and functional chromosome rearrangements, which are further enabled by telomerase overexpression. |
### Instruction:
Is aTAD2 overexpression associated with progression and prognosis in colorectal cancer?
### Response:
| These results showed that ATPase family AAA domain-containing 2 overexpression was associated with progression and prognosis of colorectal cancer. |
### Instruction:
Does maternal Immune Activation disrupt Dopamine System in the Offspring?
### Response:
| These results confirm that maternal immune activation severely impairs dopamine system and that the polyriboinosinic-polyribocytidilic acid model can be considered a proper animal model of a psychiatric condition that fulfills a multidimensional set of validity criteria predictive of a human pathology. |
### Instruction:
Is number of biopsied trophectoderm cells likely to affect the implantation potential of blastocysts with poor trophectoderm quality?
### Response:
| The implantation potential is negatively affected by the biopsied TE cell number in blastocysts with poor TE morphological score. |
### Instruction:
Does prenatal Visualization of the Pulmonary and Aortic Valves and Leaflets be Feasible Using 4-Dimensional Sonography?
### Response:
| Examination of the morphologic characteristics of the semilunar valves using STIC is feasible, which is difficult when using 2-dimensional sonography. With increasing implementation of 4-dimensional sonography, the understanding of rendered images might be useful for anyone practicing fetal echocardiography. |
### Instruction:
Does high Short-Term Blood Pressure Variability predict Long-Term Cardiovascular Mortality in Untreated Hypertensives But Not in Normotensives?
### Response:
| A high short-term BPV is significantly predictive of long-term cardiovascular mortality in untreated hypertensive but not normotensive community-based subjects, independently of office or 24-hour SBP. |
### Instruction:
Does vitamin D 20,000 IU per Week for Five Years Prevent Progression From Prediabetes to Diabetes?
### Response:
| In subjects without vitamin D deficiency, vitamin D supplementation is unlikely to prevent progression from prediabetes to diabetes. Very large studies with inclusion of vitamin D-deficient subjects will probably be needed to show such a putative effect. This study tested if supplementation with vitamin D to subjects with prediabetes will prevent progression to type 2 diabetes (T2DM). |
### Instruction:
Does epigallocatechin Gallate attenuate Partial Bladder Outlet Obstruction-induced Bladder Injury via Suppression of Endoplasmic Reticulum Stress-related Apoptosis-In Vivo Study?
### Response:
| EGCG alleviate pBOO-induced bladder injury and dysfunction via suppression of inflammation and ER stress-related apoptosis. |
### Instruction:
Does silver-nanoparticle-coated biliary stent inhibit bacterial adhesion in bacterial cholangitis in swine?
### Response:
| PU biliary stents modified with silver nanoparticles are able to alleviate the inflammation of pigs with bacterial cholangitis. Silver-nanoparticle-coated stents are resistant to bacterial adhesion. |
### Instruction:
Is low skeletal muscle mass associated with non-alcoholic fatty liver disease in Korean adults : the Fifth Korea National Health and Nutrition Examination Survey?
### Response:
| Low SMI is associated with the risk of FLI-defined NAFLD independent of other well-known metabolic risk factors in both genders. This association may differ according to age group or menopausal status. Further studies are warranted to confirm this relationship. |
### Instruction:
Do cD4+CXCR5+ T cells activate CD27+IgG+ B cells via IL-21 in patients with hepatitis C virus infection?
### Response:
| HCV infection increased the frequency of CD4+CXCR5+ T cells and decreased the frequency of CD27+IgG+ B cells. CD4+CXCR5+ T cells activated CD27+IgG+ B cells via the secretion of IL-21. |
### Instruction:
Does miR-26a regulate mouse hepatocyte proliferation via directly targeting the 3 ' untranslated region of CCND2 and CCNE2?
### Response:
| miR-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2; miR-26a also regulated p53-mediated apoptosis. Our data suggested that miR-26a may be a promising regulator in liver regeneration. |
### Instruction:
Do genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis?
### Response:
| Glycogen metabolism is not required for the maintenance of beta cell function. Glycogen accumulation in beta cells alone is not sufficient to trigger the dysfunction or loss of these cells, or progression to diabetes. |
### Instruction:
Does manual Tactile Test predict Sensorimotor Control Capability of Hands for Patients With Peripheral Nerve Injury?
### Response:
| This study indicates that the MTT is highly accurate and a significant predictor of sensorimotor performance in hands of patients with PNI. The MTT could therefore help clinicians obtain a better understanding of the sensorimotor and functional status of the hand with nerve injuries. |
### Instruction:
Does a new dynamic six degrees of freedom disc-loading simulator allow to provoke disc damage and herniation?
### Response:
| This new dynamic disc-loading simulator has proven to be able to apply complex motion combinations and allows to create artificial lesions in the disc with complex loading protocols. The aim of further tests is to better understand the mechanisms by which disc failure occurs at the microstructural level under different loading conditions. Visualisation with ultra-high field MRI at different time points is a promising method to investigate the gradual development of such lesions, which may finally lead to disc failure. These kinds of experiments will help to better investigate the mechanical failure of discs to provide new insights into the initiation of intervertebral disc herniation. This device will also serve for many other applications in spine biomechanics research. |
### Instruction:
Is socioeconomic status associated with reduced lung function in China : an analysis from a large cross-sectional study in Shanghai?
### Response:
| We found cross-sectional evidence of socioeconomic disparities in pulmonary function in Shanghai. These differences increased with age and were partially explained by potentially modifiable exposures. |
### Instruction:
Are mutations in EXOSC2 associated with a novel syndrome characterised by retinitis pigmentosa , progressive hearing loss , premature ageing , short stature , mild intellectual disability and distinctive gestalt?
### Response:
| We report a novel condition that is probably caused by altered RNA exosome function and expands the spectrum of clinical consequences of impaired RNA metabolism. |
### Instruction:
Does expression of CAIII and Hsp70 be Increased the Mucous Membrane of the Posterior Commissure in Laryngopharyngeal Reflux Disease?
### Response:
| CAIII and Hsp70 expressions were higher in LPRD patients that in non-LPRD patients, suggesting the possibility as one of biomomarker in LPRD diagnosis. |
### Instruction:
Do diurnal salivary cortisol patterns prior to pregnancy predict infant birth weight?
### Response:
| These novel findings on interpregnancy HPA axis function and subsequent pregnancy outcomes strongly support life course health approaches and underscore the importance of maternal stress physiology between pregnancies. (PsycINFO Database Record |
### Instruction:
Does long noncoding RNA NEAT1 promote laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway?
### Response:
| NEAT1 plays an oncogenic role in the tumorigenesis of LSCC and may serve as a potential target for therapeutic intervention. |
### Instruction:
Is very early initiation of chemical venous thromboembolism prophylaxis after blunt solid organ injury safe?
### Response:
| Early initiation of medical thromboembolic prophylaxis appears safe in select patients with isolated SOI following blunt trauma. A prospective multicentre study is warranted. |
### Instruction:
Is [ Older age related to hemorrhagic transformation and favorable outcomes in patients with wake-up ischemic stroke undergoing intravenous thrombolytic therapy ]?
### Response:
| Older age is not related to the favorable outcome or hemorrhagic transformation in WUIS patients undergoing multimodal image-guided intravenous thrombolytic therapy. |
### Instruction:
Are longer procedural times independently associated with symptomatic intracranial hemorrhage in patients with large vessel occlusion stroke undergoing thrombectomy?
### Response:
| Our data support an association between the risk of SICH and a longer procedure time, but no association between procedural times and the final infarction volume or long-term functional outcomes was found. |
### Instruction:
Does treatment with anti-HMGB1 monoclonal antibody affect lupus nephritis in MRL/lpr mice?
### Response:
| Treatment with monoclonal anti-HMGB-1 antibody 2G7 does not affect development of lupus nephritis, disease progression or pro-inflammatory cytokines levels in MRL/lpr mice. This indicates that blocking of HMGB1 by this neutralizing antibody does not affect lupus nephritis in MRL/lpr mice. |
### Instruction:
Do weak self-directed learning skills hamper performance in cumulative assessment?
### Response:
| Behavioral traits appear to influence student reactions to feedback on test results, with students with low self-directedness scores being particularly at risk. They can thus be identified and should receive special attention from student counselors. |
### Instruction:
Does a new oxygen modification cyclooctaoxygen bound to nucleic acids as sodium crown complex?
### Response:
| We postulate that cyclooctaoxygen is formed in most eukaryotic cells in vivo from dihydrogen peroxide in a catalase reaction catalyzed by cytidine and RNA. A molecular biological model is deduced for a first epigenetic shell of eukaryotic in vivo DNA. This model incorporates an epigenetic explanation for the interactions of the essential micronutrient selenium (as selenite) with eukaryotic in vivo DNA. |
### Instruction:
Does downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provide a unique contrast in human glioblastoma?
### Response:
| Thus, suppression of the downfield rNOE contribution might be the important step to yield the amide proton CEST contrast originally aimed at. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc. |
### Instruction:
Does cervico-ocular Reflex be Increased in People With Nonspecific Neck Pain?
### Response:
| Measuring eye movements while the participant is sitting on a rotating chair in complete darkness is technically complicated. |
### Instruction:
Does alcohol decrease Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric Oxide and Protein Kinase-Mediated Inhibition of TACE?
### Response:
| These data suggest that alcohol requires a soluble cyclase-generated cAMP-PKA pathway that is dependent upon the action of NO to inhibit TACE and TNF-α release. These findings support our observations that alcohol functions through a dual NO and PKA pathway in bronchial epithelial cells. |
### Instruction:
Does chronic Alcohol Consumption in Rats lead to Desynchrony in Diurnal Rhythms and Molecular Clocks?
### Response:
| Our findings suggest that desynchrony among internal rhythms is an important and overlooked aspect of alcohol-induced circadian disruptions. The misalignment of phases among rhythms may compromise normal physiological functions and put individuals with chronic alcohol use at greater risk for developing other physical and mental health issues. How this desynchrony occurs and the extent to which it participates in alcohol-related pathologies requires further investigation. |
### Instruction:
Do inhibitors of Calcium-Activated Anion Channels Modulate Hypnotic Ethanol Responses in Adult Sprague Dawley Rats?
### Response:
| These results suggest that CAACs are a major target of ethanol in vivo, and the regulation of these channels contributes to select behavioral actions of ethanol. |
### Instruction:
Do dexmedetomidine and ketamine show distinct patterns of cell degeneration and apoptosis in the developing rat neonatal brain?
### Response:
| These data show that ketamine and dexmedetomidine result in anatomically distinct patterns of cell degeneration and apoptosis in the brains of 7-day-old rat pups. The meaning and the clinical significance of these findings remain to be established. |
### Instruction:
Does spinal glycine transporter-1 inhibition influence the micturition reflex in urethane-anesthetized rats?
### Response:
| The results of our study indicate that GlyT-1 plays an important role in the modulation of micturition. Furthermore, these findings indicate that in urethane-anesthetized rats suppression of GlyT-1 can inhibit the micturition reflex at the spinal cord level. Thus, GlyT-1 could be a potential target for the treatment of bladder dysfunction such as overactive bladder. |
### Instruction:
Is dynamics of heart rate variability analysed through nonlinear and linear dynamics already impaired in young type 1 diabetic subjects?
### Response:
| Young subjects with type 1 diabetes mellitus have autonomic nervous system behaviour that tends to randomness compared with healthy young subjects. Moreover, this behaviour is related to reduced sympathetic and parasympathetic activity of the autonomic nervous system. |
### Instruction:
Is high plasma level of soluble RAGE independently associated with a low recurrence of atrial fibrillation after catheter ablation in diabetic patient?
### Response:
| High plasma level of sRAGE was independently associated with low AF recurrence after catheter ablation in diabetic patients, especially those with paroxysmal AF. |
### Instruction:
Does metabolomics uncover the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity?
### Response:
| Overall, these results support the notion that in situ production of PLP is required for physiological adipogenesis. |
### Instruction:
Is autophagy a major regulator of beta cell insulin homeostasis?
### Response:
| In the beta cell, transport-competent secretory peptide precursors, including proinsulin, are regulated by autophagy, whereas efficient clearance of transport-incompetent mutated forms of proinsulin by alternative degradative pathways may be necessary to avoid beta cell proteotoxicity. Reduction of autophagic degradation of proinsulin increases its residency in the secretory pathway, followed by enhanced secretion in response to stimuli. |
### Instruction:
Does short-Term Resistance Training attenuate Cardiac Autonomic Dysfunction in Obese Adolescents?
### Response:
| RT attenuated CAdyfs and BP in obese adolescents, by increasing parasympathetic activity and decreasing sympatho-vagal balance. |
### Instruction:
Does oral versus intravenous iron replacement therapy distinctly alter the gut microbiota and metabolome in patients with IBD?
### Response:
| Shifts in gut bacterial diversity and composition associated with iron treatment are pronounced in IBD participants. Despite similar clinical outcome, oral administration differentially affects bacterial phylotypes and faecal metabolites compared with IV therapy. |
### Instruction:
Does implant-delivered Alendronate cause a Dose-dependent Response on Net Bone Formation Around Porous Titanium Implants in Canines?
### Response:
| The local release of alendronate from a three-dimensional printed porous-coated implant from the three doses studied showed an overall improvement in bone apposition and periimplant bone at the intermediate dose compared with bare metal or with HA-coated controls, although the effect was more pronounced compared with bare metal. Long-term studies to show the effects of localized alendronate delivery and mechanical fixation would be the next step for future studies. |
### Instruction:
Is adipose tissue glycogen accumulation associated with obesity-linked inflammation in humans?
### Response:
| Our data establish glycogen mishandling in adipose tissue as a potential key feature of inflammatory-related metabolic stress in human obesity. |
### Instruction:
Does eBF2 promote the recruitment of beige adipocytes in white adipose tissue?
### Response:
| Taken together, our results demonstrate that EBF2 controls the beiging process and suggest that activation of EBF2 in WAT could be used to reduce obesity. |
### Instruction:
Does stress-induced activation of brown adipose tissue prevent obesity in conditions of low adaptive thermogenesis?
### Response:
| Our findings demonstrate that thermogenesis and BAT function are determinant of the resilience or vulnerability to stress-induced obesity. Our data support a model in which adrenergic and purinergic pathways exert complementary/synergistic functions in BAT, thus suggesting an alternative to βARs agonists for the activation of human BAT. |
### Instruction:
Does skeletal muscle salt inducible kinase 1 promote insulin resistance in obesity?
### Response:
| SIK1 is dispensable for glycemic control on chow diet. SIK1 promotes insulin resistance on high fat diet by a cell-autonomous mechanism in skeletal muscle. Our study establishes SIK1 as a promising therapeutic target to improve skeletal muscle insulin sensitivity in obese individuals without deleterious effects on hepatic glucose production. |
### Instruction:
Do variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease?
### Response:
| In WES and targeted exome sequence analyses of an infant with severe IBD characterized by granulomatous colitis and severe perianal disease, we identified a homozygous variant of TRIM22 that affects the ability of its product to regulate NOD2. Combined computational and functional studies showed that the TRIM22-NOD2 network regulates antiviral and antibacterial signaling pathways that contribute to inflammation. Further study of this network could lead to new disease markers and therapeutic targets for patients with very early and adult-onset IBD. |
### Instruction:
Does point-of-Care Multi-Organ Ultrasound improve Diagnostic Accuracy in Adults Presenting to the Emergency Department with Acute Dyspnea?
### Response:
| In this small study, POCUS evaluation of the heart, lungs and IVC improved the treating physician's immediate overall diagnostic accuracy for ADHF, COPD/asthma and pneumonia and was particularly useful to immediately exclude ADHF as the cause of acute dyspnea. |
### Instruction:
Does high-resolution Quantitative Computed Tomography demonstrate Structural Defects in Cortical and Trabecular Bone in IBD Patients?
### Response:
| IBD patients develop significant cortical bone loss, impairing bone strength. Trabecular bone loss is limited to CD patients, who exhibit a more severe bone phenotype compared with UC patients. |
### Instruction:
Does e3 Ubiquitin ligase RNF183 be a Novel Regulator in Inflammatory Bowel Disease?
### Response:
| RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IκBα, thereby inducing NF-κB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of IBD. |
### Instruction:
Does histone deacetylase 2 regulate doxorubicin ( Dox ) sensitivity of colorectal cancer cells by targeting ABCB1 transcription?
### Response:
| Our data revealed that HDAC2 can regulate Dox sensitivity of CRC cells by targeting ABCB1 transcription. It suggested that HDAC2 might be an important target for CRC therapy. Further, the combination of HDAC2-specific inhibitor and anticancer drugs including Dox might be an efficiency approach to elevate the treatment outcome of CRC. |
### Instruction:
Does cholestasis reveal Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome?
### Response:
| Cholestasis is a frequent symptom at presentation of PSIS during the neonatal period that may help earlier diagnosis and that indicates a profound cortisol deficiency. |
### Instruction:
Do cardiovascular alterations do exist in children with stage-2 chronic kidney disease?
### Response:
| Cardiovascular deteriorations appear in children with stage-2 CKD. Good control of BP and decreasing the level of FGF23 may be useful to slow down the progression of cardiovascular complications. |
### Instruction:
Are epitelial-to-mesenchimal transition and invasion upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells?
### Response:
| These findings present a novel role for GrB as upmodulator of EMT in CRC cells. Moreover, these results support the use of DHA, a dietary compound without toxic effects, as adjuvant in CRC therapy. |
### Instruction:
Does nerve Growth Factor promote Angiogenesis and Skeletal Muscle Fiber Remodeling in a Murine Model of Hindlimb Ischemia?
### Response:
| NGF transfection can promote NGF and VEGF protein expression which not only can induce angiogenesis but also induce type I muscle fiber expression in ischemic limbs. |
### Instruction:
Is methylprednisolone Pulse Treatment of Graves ' Ophthalmopathy Associated with Secondary Adrenocortical Insufficiency?
### Response:
| Transient suppression of the HPA axis with secondary adrenocortical insufficiency does not seem to be a common phenomenon after intravenous methylprednisolone pulse therapy for GO. Therefore, routine precautions are not necessary. However, our results do not exclude that transient secondary adrenocortical insufficiency might occur occasionally. |
### Instruction:
Does haplo-insufficiency of both BubR1 and SGO1 accelerate cellular senescence?
### Response:
| Taken together, our observations suggest that combined deficiency of BubR1 and Sgo1 accelerates cellular senescence. |
### Instruction:
Do ganoderma lucidum total triterpenes prevent γ-radiation induced oxidative stress in Swiss albino mice in vivo?
### Response:
| The results of the present study thus revealed the potential therapeutic use of Ganoderma total triterpenes as an adjuvant in radiation therapy. |
### Instruction:
Is the specificity of Pavlovian regulation associated with recovery from depression?
### Response:
| Depression is associated with an abnormal influence of emotional reactions on decision-making in a way that may predict recovery. |
### Instruction:
Does nebivolol ameliorate asymmetric dimethylarginine-induced vascular response in rat aorta via β3 adrenoceptor-mediated mechanism?
### Response:
| Nebivolol ameliorates the ADMA-induced vascular responses in rat aorta, at least in part, by mechanisms involving β3 adrenoceptor. |
### Instruction:
Does phenethyl isothiocyanate enhance TRAIL-induced apoptosis in oral cancer cells and xenografts?
### Response:
| We showed for the first time that PEITC overcomes TRAIL resistance in oral cancer cells and enhance the therapeutic potential of TRAIL in vivo. |
### Instruction:
Is serum uric acid associated with non-dipping circadian pattern in young patients ( 30-40 years old ) with newly diagnosed essential hypertension?
### Response:
| Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension. |
### Instruction:
Do epigenome overlap measure ( EPOM ) for comparing tissue/cell types based on chromatin states?
### Response:
| The proposed EPOM measure demonstrates superior capability in grouping and finding a clear correspondence map of biological samples from different tissue and cell types. The identified associated enhancers and promoters provide a comprehensive catalog to study distinct biological processes and disease variants in different tissue and cell types. Our results also find that the associated promoters exhibit more cell-type-specific functions than the associated enhancers do, suggesting that the non-associated promoters have more housekeeping functions than the non-associated enhancers. |
### Instruction:
Is prefrailty in community-dwelling older adults associated with nutrition status?
### Response:
| The results showed that nutritional assessment can be employed with community-dwelling older adults. In particular, prefrailty and body mass index were key factors that affected nutritional status in older adults. |
### Instruction:
Does ophiopogonin D maintain Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress?
### Response:
| OPD is a novel CYP2J3 inducer that may offer a therapeutic benefit in treatment of cardiovascular diseases related to disturbance of Ca(2+) homeostasis and ER stress. |
### Instruction:
Is impairment of gastric accommodation induced by water-avoidance stress mediated by 5-HT2B receptors?
### Response:
| Stress-induced impairment of GA may be mediated by an increased responsiveness of 5-HT2B receptors, and activation of the 5-HT2B receptor signaling pathway may have an inhibitory effect on nitric oxide function. |
### Instruction:
Does cardiac Slo2.1 Is require for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning?
### Response:
| Slick (Slo2.1) is required for both VA-stimulated K flux and for the APC-induced cardioprotection. |
### Instruction:
Does mean platelet volume predict the glycemic control deterioration in diabetes mellitus type 2 patients?
### Response:
| Mean platelet volume correlates with glycemic control markers in DMT2 patients. It could be used as a simple and cost-effective predictor of deterioration of glucoregulation. |
### Instruction:
Does serum Vascular Adhesion Protein-1 predict End-Stage Renal Disease in Patients with Type 2 Diabetes?
### Response:
| In conclusion, serum VAP-1 can predict ESRD and is a useful biomarker to improve risk stratification in type 2 diabetic subjects. |
### Instruction:
Does ethosuximide affect Paired-Pulse Facilitation in Somatosensory Cortex of WAG\Rij Rats as a Model of Absence Seizure?
### Response:
| These experiments indicate that Ethosuximide has effects on presynaptic facilitation in somatosensory cortex inhibitory loops by alteration in GABA levels that leads to a markedly diminished PPF in paired-pulse stimulation. |
### Instruction:
Does vessel Dilation attenuate Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats?
### Response:
| Our dynamic angiographic data demonstrated that diabetes could impair the cerebral arterial reactivity. Prolonged fasudil treatment could attenuate arterial dysfunction and improve the prognosis of ischemic stroke by affecting both the large and small vasculature. |
### Instruction:
Are minor Components of Micropapillary and Solid Subtypes in Lung Adenocarcinoma Predictors of Lymph Node Metastasis and Poor Prognosis?
### Response:
| Minor components of micropapillary and/or solid subtypes of lung adenocarcinoma are correlated with lymph node metastasis and poor prognosis. Thus, it is beneficial to focus not only on predominant subtypes but also minor components to predict prognoses and make therapeutic strategies more comprehensively. |
### Instruction:
Is severe neutropenia during cabazitaxel treatment associated with survival benefit in men with metastatic castration-resistant prostate cancer ( mCRPC ) : A post-hoc analysis of the TROPIC phase III trial?
### Response:
| This post-hoc analysis of TROPIC suggests that the occurrence of grade ≥3 neutropenia with cabazitaxel is associated with improved OS and PFS. Patients with a low NLR at baseline were more likely to develop grade ≥3 neutropenia during cabazitaxel therapy and showed the longest OS. High NLR at baseline and no grade ≥3 neutropenia during therapy was associated with poor outcomes which may suggest insufficient drug exposure or a limited impact on the tumour-associated immune response. Primary or secondary prophylactic use of G-CSF had no adverse impact for outcome. If prospectively confirmed, these results would justify maintaining the intended cabazitaxel dose of 25 mg/m(2) whenever possible. |
### Instruction:
Does helix B Surface Peptide protect Cardiomyocytes Against Hypoxia/Reoxygenation-induced Apoptosis Through Mitochondrial Pathways?
### Response:
| These results indicated that HBSP has protective effects against H/R-induced apoptosis by regulating the mitochondrial pathway. This mechanism involves inhibiting mitochondrial ROS generation, inhibiting caspase-3 activity, reducing ΔΨm collapse, reducing cytochrome release, and balancing anti and proapoptotic Bcl-2 family proteins. |
### Instruction:
Are morphometric features of posterior cranial fossa different between Chiari I malformation with and without syringomyelia?
### Response:
| Small size of the posterior fossa was detected both in CMI cases with and without syrinx. The clivus gradient served as the only morphologic difference in the PCF between CMI-S and CMI-only patients and was correlated with the severity of the syrinx, may support the theory that the restricted circulation of cerebrospinal fluid at the anterior paramedial subarachnoid space contributes to the formation of a syrinx. |
### Instruction:
Is serum albumin an early predictor of complications after liver surgery?
### Response:
| Early postoperative drop of serum albumin reflects the intensity of the surgical stress and may predict complications after liver surgery. Serum albumin is a biomarker displaying precious features and deserving further prospective investigations. |
### Instruction:
Does the Air Quality Health Index and Emergency Department visit for Otitis Media?
### Response:
| These findings confirm that there is an association between the multipollutant Air Quality Health Index and emergency department visits for OM. The findings can be used to inform risk communication, patient education, and policy. |
### Instruction:
Is the anterior chamber of the eye a transplantation site that supports and enables visualisation of beta cell development in mice?
### Response:
| Altogether, we show that the ACE is able to support growth, differentiation and function of a developing pancreatic bud across time in vivo. |
### Instruction:
Are radiographers valuable contributors in interpreting computed tomography colonography?
### Response:
| This study shows that radiographers can be a valuable contribution in the interpretation of CTC. |
### Instruction:
Does antibody-Mediated Blockade of Phosphatidylserine enhance the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts?
### Response:
| Overall, these results strongly support the combination of bavituximab with sorafenib as a promising systemic therapeutic strategy for the treatment for advanced HCC patients. |
### Instruction:
Does hepatocyte nuclear factor 6 inhibit the growth and metastasis of cholangiocarcinoma cells by regulating miR-122?
### Response:
| The results indicate that HNF6 may serve as a tumor suppressor by regulating miR-122, and its overexpression may represent a mechanism-based therapy for CCA. |
### Instruction:
Does histone Acetylation in Microglia contribute to Exercise-Induced Hypoalgesia in Neuropathic Pain Model Mice?
### Response:
| This article presents the importance of epigenetic modification in microglia in producing EIH. The current research is not only helpful for developing novel nonpharmacological therapy for NPP, but will also enhance our understanding of the mechanisms and availability of exercise in our daily life. |
### Instruction:
Do poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways?
### Response:
| By comparing the effects exerted by poorly soluble Co3O4P with those obtained in the presence of soluble cobalt chloride (CoCl2), we demonstrated that the genotoxic effects of Co3O4P are not simply due to the released Co(2+) but are induced by the particles themselves, as genotoxicity is observed at very low Co3O4P concentrations. |
### Instruction:
Does protection against cardiac hypertrophy by geniposide involve the GLP-1 receptor / AMPKα signalling pathway?
### Response:
| Geniposide protected against cardiac hypertrophy via activation of the GLP-1 receptor/AMPKα pathway. Geniposide is a potential therapeutic drug for cardiac hypertrophy. |
### Instruction:
Is 7-aminoclonazepam superior to clonazepam for detection of clonazepam use in oral fluid by LC-MS/MS?
### Response:
| 7AC should be the analyte measured in OF for the detection of CLON use. |
### Instruction:
Is dysphoria a risk factor for depression in medically ill older people?
### Response:
| Dysphoric mood results in depression in older people with medical health problems. Copyright © 2016 John Wiley & Sons, Ltd. |
### Instruction:
Is implantation depth measured by 64-slice computed tomography associated with permanent pacemaker requirement following transcatheter aortic valve implantation with the Core Valve ( ® ) system?
### Response:
| Implantation depth of the Core Valve(®) into the LVOT was associated with post-procedural PM requirement. Thereby, a cut-off value of 6mm, as measured by 64-slice CT, proved useful to define patients at risk for PM requirement. |
### Instruction:
Is promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy?
### Response:
| An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes. |
### Instruction:
Is fibroblast growth factor 23 associated with left ventricular hypertrophy , not with uremic vasculopathy in peritoneal dialysis patients?
### Response:
| Our results show that FGF23 is associated with LVH but not with endothelial dysfunction, arterial stiffness, or vascular calcification in PD patients. |
### Instruction:
Is transesophageal Echocardiographic Measurement of Cardiac Index by the Prosthetic Mitral Valve Method Similar to the Continuous Thermodilution Method Via a Pulmonary Artery Catheter?
### Response:
| A relatively weak correlation and lack of agreement between values of CI(PAC) and CI(MV) were observed in patients undergoing double-valve replacement. Therefore, transesophageal echocardiography might not be interchangeable with PAC-TD for measuring cardiac output or cardiac index. A regression equation is needed to correct the probable value of CI(PAC). CI(MV) might be useful as a quantitative or semi-quantitative cardiac output measurement. |
### Instruction:
Do [ Anticholinergics affect the sexual function in women diagnosed with multiple sclerosis ]?
### Response:
| In this limited series of "naive" patients with MS, no impact of anticholinergic therapy on vaginal lubrication or sexual quality was observed. |
### Instruction:
Does physiological oxygen tension modulate soluble growth factor profile after crosstalk between chondrocytes and osteoblasts?
### Response:
| These results not only indicate the importance of crosstalk between chondrocytes and osteoblasts but also improve our understanding of the mechanisms underlying homoeostatic maintenance of endochondral bone. |
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