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### Instruction:
Does obstructive lung disease increase lung cancer mortality among female never-smokers in Hong Kong?
### Response:
| Obstructive lung disease exerted differential effects on lung cancer mortality across different sex and smoking subgroups in this Asian population, with a conspicuous absence of effect among female never-smokers. |
### Instruction:
Does continuous wound infusion with ropivacaine fail to provide adequate analgesia after caesarean section?
### Response:
| Compared to saline control, continuous wound infusion with ropivacaine failed to reduce the use of intravenous oxycodone patient-controlled analgesia or pain scores. Intrathecal morphine decreased oxycodone consumption by 46% in the first 24 h after surgery when compared to continuous ropivacaine wound infusion. |
### Instruction:
Is serum 1,5-anhydroglucitol associated with diabetic retinopathy in Type 2 diabetes?
### Response:
| 1,5-Anhydroglucitol levels show close associations with diabetic retinopathy, especially among patients under moderate glucose control, but not with albuminuria. These results suggest that 1,5-anhydroglucitol might be a complementary marker for targeting higher risk group. |
### Instruction:
Is genetic admixture associated with plasma hemostatic factor levels in self-identified African Americans and Hispanics : the Multi-Ethnic Study of Atherosclerosis?
### Response:
| Greater African ancestry among African Americans and Hispanics was associated with higher levels of several hemostatic factors, notably fibrinogen. These results suggest that genetic heterogeneity contributes, albeit modestly, to racial/ethnic differences in hemostatic factor levels. |
### Instruction:
Does high-sensitivity flow cytometry provide access to standardized measurement of small-size microparticles -- brief report?
### Response:
| Recent improvements in FCM provide access to previously undetectable MP and represent a new opportunity to enhance their impact as biomarkers in clinical practice. |
### Instruction:
Do consensus document on the overlap phenotype COPD-asthma in COPD?
### Response:
| It is necessary to expand our knowledge about this phenotype in order to establish adequate guidelines and recommendations for its diagnosis and treatment. |
### Instruction:
Does topical ocular sodium 4-phenylbutyrate rescue glaucoma in a myocilin mouse model of primary open-angle glaucoma?
### Response:
| Topical ocular PBA reduces glaucomatous phenotypes in Tg-MYOC(Y437H) mice, most likely by reducing myocilin accumulation and ER stress in the TM. Topical ocular PBA could become a novel treatment for POAG patients with myocilin mutations. |
### Instruction:
Are genetic loci on chromosomes 4q25 , 7p31 , and 12p12 associated with onset of lone atrial fibrillation before the age of 40 years?
### Response:
| Three SNPs, rs2200733 (4q25), rs3807989 (7p31), and rs11047543 (12p12), were associated with early-onset lone AF. All 3 SNPs are positioned close to genes that in previous studies have been demonstrated to be important for cardiac morphology/development, thereby suggesting a link between these SNPs and structural heart disease. Our results however, indicate that variants in these 3 loci are associated with AF through mechanisms that do not involve major structural abnormalities in the heart. |
### Instruction:
Does gamma radiation induce senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments?
### Response:
| Mesenchymal stem cells isolated from bone marrow and periodontal ligament respond to ionizing radiation by induction of stress-induced premature senescence without apparent differences in their radiation response. |
### Instruction:
Does vitamin E supplementation alter physiological performance at fixed blood lactate concentrations in trained runners?
### Response:
| Daily VE supplementation for 35 days does not enhance or impair physiological performance at fixed blood lactate concentrations. Long-term VE supplementation for the purposes of performance enhancement is not recommended. |
### Instruction:
Do influence of a new bicycle crank design on aerobic parameters of non-cyclists?
### Response:
| The favourable results obtained in this study using the new chainring may be in consequence of a more efficient biomechanics of pedalling that does not reflect changes in O2 consumption and CO2 produced. However, it is not possible to exclude that involuntary motivational factors may have induced the difference in the time test since it was not possible to blind subjects about the two crank systems. Further investigations are necessary to confirm the results of this exploratory study and give a more exhaustive explanation about the mechanisms that allow the possible better performance with this new chainring system. |
### Instruction:
Does aerobic training alter CRP in apparently healthy , untrained men?
### Response:
| Regular aerobic training does not appear to affect CRP concentrations in apparently healthy, untrained men despite significant improvements in bodyweight, BF%, BMI, and VO2max. |
### Instruction:
Does preoperative administration of etoricoxib in patients undergoing hip replacement cause inhibition of inflammatory mediators and pain relief?
### Response:
| Administration of etoricoxib 2 h before surgery allows for an effective drug concentration in critical tissues, a reduction of the production of pro-inflammatory mediators and for better pain relief. |
### Instruction:
Does matrix metalloproteinase inhibitor attenuate cochlear lateral wall damage induced by intratympanic instillation of endotoxin?
### Response:
| The MMP inhibitors oxytetracycline and ilomastat protect from cochlear lateral wall damage caused by LPS-induced labyrinthitis. |
### Instruction:
Does methicillin-resistant Staphylococcus capitis with reduced vancomycin susceptibility cause late-onset sepsis in intensive care neonates?
### Response:
| A clonal population of methicillin-resistant S. capitis strains has spread into several French NICUs. These isolates exhibit reduced susceptibility to vancomycin, which is the most widely used antimicrobial agent in the NICU setting. |
### Instruction:
Are vascular clips safe and a great cost-effective technique for arterial and venous control in laparoscopic nephrectomy : single-center experience with 1834 laparoscopic nephrectomies?
### Response:
| Hem-o-lok and metallic vascular clips applied properly by trained surgeons according to published safety measures provide a safe and considerable cost-saving option for vascular control in laparoscopic nephrectomy. |
### Instruction:
Is the risk of a persistent glucose metabolism impairment after gestational diabetes mellitus increased in patients with polycystic ovary syndrome?
### Response:
| Patients with PCOS are at increased risk for a persistent impaired glucose metabolism after GDM. |
### Instruction:
Does pure alumina bearings with cementless stem versus sandwich bearings with cemented stems in total hip arthroplasty?
### Response:
| The sandwich design of the acetabular bearings can not reduce the migration rate in ceramic bearings but increase the liner fracture rate compared to pure ceramic liners. The high loosening rate in fluted and taped designed cemented stems with sandwich liners warrant caution to their use. |
### Instruction:
Do interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells?
### Response:
| Our finding indicates that glioma cells without self-renewal capability in standard conditions could also contribute to glioma malignancy when cytokines, such as IL-1β and TGF-β, are present in the tumor environment. Targeting GSC-promoting cytokines that are highly expressed in glioblastomas may contribute to the development of more effective glioma therapies. |
### Instruction:
Is agreement between cardiac outputs by four-dimensional echocardiography and thermodilution method poor?
### Response:
| The agreement between COs by 4D echo and standard PAC thermodilution technique was poor. 4D echo underestimates CO as compared with PAC. This is most likely caused by the analysis software or low frame rate inherent to the technique. |
### Instruction:
Does radiation exposure have increased in trauma patients over time?
### Response:
| The number of CT scans per trauma patient has more than doubled over 6 years, generating more radiation exposure and charges per patient, despite no change in mortality or injury severity. Judicious use of advanced imaging may control risks and costs without compromising care. |
### Instruction:
Does early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improve survival?
### Response:
| Many tumor proteins could be exploited for targeted therapy with the NK-92 cell line; combined with the mounting safety evidence for transcranial ultrasound, these results may soon be translatable to a highly targeted treatment option for patients with brain tumors. |
### Instruction:
Does dixon Sequence with Superimposed Model-Based Bone Compartment provide Highly Accurate PET/MR Attenuation Correction of the Brain?
### Response:
| Bone compartment and linear AC modifications result in a highly accurate MR AC method in subjects with suspected neurodegeneration. This prototype MR AC solution appears equivalent to other recently proposed solutions and does not require additional MR sequences and scanning time. These data also suggest that exclusively model-based MR AC approaches may be adversely affected by common individual variations in skull anatomy. |
### Instruction:
Does curcumin inhibit the proliferation and invasion of human osteosarcoma cell line MG-63 by regulating miR-138?
### Response:
| Curcumin could increase the expression of hsa-miR-138, hsa-miR-138 inhibited cell proliferation and invasive ability by inhibition of its target genes. |
### Instruction:
Is fibroblast growth factor-21 positively associated with atrial fibrosis in atrial fibrillation patients with rheumatic heart disease?
### Response:
| FGF-21 might involve in the development and maintenance of atrial fibrosis in atrial fibrillation with rheumatic heart disease, and FGF-21 could be used as a novel biomarker to evaluate myocardial fibrosis in the future. |
### Instruction:
Is superfertility more prevalent in obese women with recurrent early pregnancy miscarriage?
### Response:
| Our findings suggest that obese women may have a greater efficacy to achieve pregnancy, but with an increased risk of miscarriage, which may suggest the possible metabolic effects of obesity on endometrium. |
### Instruction:
Does risk of Asthma from Cesarean Delivery depend on Membrane Rupture?
### Response:
| We confirmed cesarean delivery to be a risk factor for childhood asthma. This effect was more pronounced for cesarean delivery performed before rupture of membranes. |
### Instruction:
Are two nonspecific lipid transfer proteins ( nsLTPs ) from tomato seeds associated to severe symptoms of tomato-allergic patients?
### Response:
| We herein described two novel allergens from tomato seeds that belong to the nonspecific lipid transfer protein family classes 1 and 2, respectively. This is the first work associating IgE reactivity to these proteins with severe symptoms of certain tomato-allergic patients. Therefore, they are optimal candidates for clarifying the diagnosis of the tomato allergy. |
### Instruction:
Does evolutionary analysis across mammals reveal distinct classes of long non-coding RNAs?
### Response:
| Our results highlight that lncRNAs are not a homogenous class of molecules but rather a mixture of multiple functional classes with distinct biological mechanism and/or roles. Our novel comparative methods for lncRNAs reveals 233 constrained lncRNAs out of tens of thousands of currently annotated transcripts, which we make available through the slncky Evolution Browser. |
### Instruction:
Does a Novel Feed-Forward Modeling System lead to Sustained Improvements in Attention and Academic Performance?
### Response:
| The FFM appeared to be an effective intervention for the treatment of ADHD and improving academic performance. This FFM training intervention shows promise as a first-line treatment for ADHD while improving academic performance. |
### Instruction:
Does hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition protect Against Development of Atherosclerosis?
### Response:
| HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis. The mechanisms involve beneficial modulation of the serum lipid profile and innate immune system and reduced inflammation. |
### Instruction:
Does hRP-3 protect the hepatoma cells from glucose deprivation-induced apoptosis?
### Response:
| We propose that glucose deprivation-induced HRP-3 up-regulation potentially plays a major role in protecting HCC cells against apoptosis caused by energy pressure. |
### Instruction:
Is down-regulation of NF-κB expression by n-3 fatty acid-rich linseed oil modulated by PPARγ activation , eicosanoid cascade and secretion of cytokines by macrophages in rats fed partially hydrogenated vegetable fat?
### Response:
| Detrimental effects of dietary PHVF in enhancing pro-inflammatory agents in rats could be significantly reduced by providing ALA (n-3 PUFA)-rich LSO. |
### Instruction:
Does targeting oliguria reversal in perioperative restrictive fluid management influence the occurrence of renal dysfunction : A systematic review and meta-analysis?
### Response:
| Our data suggest that, even though event numbers are small, perioperative restrictive fluid management does not increase oliguria or postoperative ARF while decreasing intraoperative fluid intake, irrespective of targeting reversal of oliguria or not. |
### Instruction:
Is iL15 polymorphism associated with advanced fibrosis , inflammation-related biomarkers and virological response in human immunodeficiency virus/hepatitis C virus coinfection?
### Response:
| The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of SVR to pegIFN-alpha/RBV therapy. |
### Instruction:
Does concordance of Expert and Parental Opinion about Hypospadias Surgical Outcome be Severity Dependent?
### Response:
| The level of concordance of opinion among parents and urologists with regard to their level of satisfaction with surgical outcomes is related to hypospadias severity, whereby the greatest level of concordance of opinion was achieved among most severe cases. This study underscores the need for longer follow-up to properly assess satisfaction with hypospadias repair, especially for the less severe forms of the condition. |
### Instruction:
Does a brief motivational interview with action and coping planning components enhance motivational autonomy among volunteer blood donors?
### Response:
| This study supports motivational interviewing with action and coping planning as a novel strategy to promote key contributors to donor motivation. |
### Instruction:
Are shared and divergent pathways for flower abscission triggered by gibberellic acid and carbon starvation in seedless Vitis vinifera L?
### Response:
| Globally, the results suggest that chemical and environmental cues induced contrasting effects on inflorescence metabolism, triggering flower abscission by different mechanisms and pinpointing the participation of novel abscission regulators. Grapevine showed to be considered a valid model to study molecular pathways of flower abscission competence acquisition, noticeably responding to independent stimuli. |
### Instruction:
Does low tidal volume ventilation preconditioning ameliorate lipopolysaccharide-induced acute lung injury in rats?
### Response:
| Low tidal volume ventilation preconditioning can attenuate release of pulmonary pro-inflammatory cytokines and decrease the AI induced by severe sepsis. Early protection seems to be mediated partly through inhibition of activation of a Rho pathway. |
### Instruction:
Are polymorphisms in NRGN associated with schizophrenia , major depressive disorder and bipolar disorder in the Han Chinese population?
### Response:
| Despite the association between NRGN and psychoses we have found, we failed to validate the positive variant rs12807809, which was reported in the Caucasian genome-wide association study both in our single site association test and the meta-analysis. Functional studies are needed to illuminate the role of NRGN in the pathogenesis of these mental disorders. |
### Instruction:
Is why the radial augmentation index low in patients with diabetes : The J-HOP study?
### Response:
| The lower rAI in DM associated with higher cPP compared to non-DM suggests proximal conduit-predominant arterial stiffening causing reduced reflection coefficients at systemic reflection sites. As renal function decreases, a cPP increase may overcome the increase of augmentation pressure in the DM group. |
### Instruction:
Does miRNA-21 Expression decrease from Primary Tumors to Liver Metastases in Colorectal Carcinoma?
### Response:
| In the context of previous studies demonstrating increased miRNA-21 expression in metastatic primary tumors, our findings raise the question whether miRNA-21 might be involved in the initiation but not in the perpetuation and growth of metastases. |
### Instruction:
Does early Life Growth predict Pubertal Development in South African Adolescents?
### Response:
| In boys and girls, both height and body mass index in early childhood predicted the trajectory of pubertal development. This may provide a tool to identify children at risk of early pubertal onset. |
### Instruction:
Are anxiety symptoms during hospitalization of elderly associated with increased risk of post-discharge falls?
### Response:
| Anxiety at time of hospitalization is associated with falls 30-days post-discharge, controlling for several well-known confounders. This relationship is partially mediated by functional decline. Identifying patients with anxiety for inclusion in targeted rehabilitation interventions may be an important component of fall prevention strategies. |
### Instruction:
Does association of MTHFR C677T Genotype With Ischemic Stroke be Confined to Cerebral Small Vessel Disease Subtype?
### Response:
| MTHFR C677T was associated with magnetic resonance imaging-confirmed lacunar stroke, but not large artery or cardioembolic stroke. The association may act through increased susceptibility to, or interaction with, high blood pressure. This heterogeneity of association might explain the lack of effect of lowering homocysteine in secondary prevention trials which included all strokes. |
### Instruction:
Do cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation?
### Response:
| Cigarette smoke exposure may predispose to ARDS through an abnormal response to a 'second hit,' with increased alveolar-capillary membrane permeability, exaggerated inflammation, increased epithelial injury and endothelial dysfunction. LPS inhalation may serve as a useful experimental model for evaluation of the acute pulmonary effects of existing and new tobacco products. |
### Instruction:
Does hippocampal dysfunction define disease onset in Huntington 's disease?
### Response:
| This study highlights the merit of using analogous tests in the laboratory and clinic and demonstrates that hippocampal impairments are an early feature of HD in patients as previously shown in rodent models of the disease. As such, they could be used not only to assist in the diagnosis of disease onset, but may also be useful as an outcome measure in future therapeutic trials. |
### Instruction:
Are circulating TGF-β1 levels negatively correlated with sclerostin levels in early postmenopausal women?
### Response:
| Our findings suggest that serum TGF-β1 level increases during postmenopause and declines in old age. Sclerostin production is inhibited by TGF-β1 during early postmenopause. |
### Instruction:
Does multiparametric flow cytometric analysis of whole blood reveal changes in minor lymphocyte subpopulations of multiple sclerosis patients?
### Response:
| Multiparametric flow cytometry analysis of whole blood is a robust, reproducible, and sensitive technology to monitor the effect of MS treatments even in minor lymphocyte subpopulations that might represent useful biomarkers of treatment response. |
### Instruction:
Does rIG-I inhibit the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1?
### Response:
| RIG-I has the potential to exert anticancer activity in BRAF-mutant melanoma via controlling IFNβ production and MAPK signaling. This is the first study showing that RIG-I activation results in MKP-1-mediated inhibition of cell proliferation via controlling the p38-HSP27, c-Jun and rpS6 pathways thus identifying RIG-I and MKP-1 as novel and promising therapeutical targets. |
### Instruction:
Does progesterone modulate endothelial progenitor cell ( EPC ) viability through the CXCL12/CXCR4/PI3K/Akt signalling pathway?
### Response:
| The CXCL12/CXCR4/PI3K/pAkt signalling pathway increased progesterone-induced EPC viability. |
### Instruction:
Does cytomegalovirus Infection Minimally affect the Frequencies of B-Cell Phenotypes in Peripheral Blood of Younger and Older Adults?
### Response:
| These results emphasize the importance of including CMV serostatus in the analysis of immune signatures. Because the proportion of the population infected with CMV increases with age, the effect of CMV rather than age could confound analyses seeking age-associated changes to human immunity. |
### Instruction:
Does sequencing of FTO and ALKBH5 in men undergoing infertility work-up identify an infertility-associated variant and two missense mutations?
### Response:
| The discovery of two missense mutations with potentially detrimental effect on the functionality of the methylation eraser protein FTO, as well as a genetic variant of the same protein that is associated with altered semen quality could suggest that aberrant demethylation of messenger RNA is a factor involved in reduced male fertility. |
### Instruction:
Does a Moderate Carnitine Deficiency exacerbate Isoproterenol-Induced Myocardial Injury in Rats?
### Response:
| Our study suggests that carnitine deficiency exposes the heart to a greater risk of injury when sympathetic nerve activity is greatly stimulated, for example during emotional, mental or physical stress. |
### Instruction:
Do interaction network of tobacco etch potyvirus NIa protein with the host proteome during infection?
### Response:
| Potyviral NIa targets many host elements during infection, establishing a network in which information is efficiently transmitted. |
### Instruction:
Does hydrodynamic loading in concomitance with exogenous cytokine stimulation modulate differentiation of bovine mesenchymal stem cells towards osteochondral lineages?
### Response:
| Moving forward, these results suggest bioprocessing conditions which minimize exposure of chondrogenic cultures to fluid shear stress to avoid undesirable differentiation of the MSC population. |
### Instruction:
Is impaired barrier function in patients with house dust mite-induced allergic rhinitis accompanied by decreased occludin and zonula occludens-1 expression?
### Response:
| We found impaired nasal epithelial barrier function in patients with HDM-induced AR, with lower occludin and zonula occludens-1 expression. IL-4 disrupted epithelial integrity in vitro, and FP restored barrier function. Better understanding of nasal barrier regulation might lead to a better understanding and treatment of AR. |
### Instruction:
Do effects of sustained release growth hormone treatment during the rehabilitation of adult severe burn survivors?
### Response:
| Our results suggest that SR-hGH treatment during the rehabilitation of adult burn survivors positively affects physical fitness levels, muscle power, and metabolic processes, although further confirmation through research of metabolic pathways in burn survivors is required. |
### Instruction:
Is erythrophagocytosis by plasmacytoid dendritic cells and monocytes enhanced during inflammation?
### Response:
| The nature of APCs that consume transfused RBCs is changed by inflammation. Given that APCs initiate humoral immune responses, these findings provide potential mechanistic insight into how inflammation regulates RBC alloimmunization. |
### Instruction:
Does induction of heme oxygenase-1 by hemin protect lung against orthotopic autologous liver transplantation-induced acute lung injury in rats?
### Response:
| Hemin pretreatment, by enhancing HO-1 induction, increased lung antioxidant capacity and reduced inflammatory stress,protected the lung from OALT-induced ALI at early stage of reperfusion. |
### Instruction:
Are oral nutritional supplements in a randomised trial more effective than dietary advice at improving quality of life in malnourished care home residents?
### Response:
| This study in malnourished care home residents indicates that ONS can improve QoL and nutritional intake more effectively than dietary advice alone. |
### Instruction:
Does supplementation of Korean Red Ginseng improve behavior deviations in animal models of autism?
### Response:
| As a food and herbal supplement with various known benefits, KRG demonstrated its therapeutic potential in rescuing abnormal behaviors related to autism caused by prenatal environmental exposure to VPA. |
### Instruction:
Are synovial Cytokines and the MSIS Criteria Useful for Determining Infection Resolution After Periprosthetic Joint Infection Explantation?
### Response:
| IL-6 and IL-1β demonstrated high sensitivities to diagnose PJI and showed the greatest decrease between first and second stages, which may potentially be used to monitor treatment response to PJI. However, cytokines and MSIS criteria had low sensitivity to rule out infection before reimplantation. |
### Instruction:
Do bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration?
### Response:
| The bioactive factors examined in this study have differing clinical effects on musculoskeletal tissue. Differences in the cellular and cytokine composition between PRP and BMC and between BMC systems should be taken into consideration by the clinician when choosing a biologic for therapeutic application. |
### Instruction:
Does smoking increase the risk of early meniscus repair failure?
### Response:
| Smoking is associated with significantly increased risk of early meniscus repair failure as defined by the incidence of repeat surgery on the index meniscus. |
### Instruction:
Does constitutive expression of SMAR1 confer susceptibility to Mycobacterium tuberculosis infection in a transgenic mouse model?
### Response:
| SMAR1 transgenic mice exhibited susceptibility to M. tuberculosis infection in vivo irrespective of genetic background. This susceptibility was attributed to downregulation of Th1 response and its hallmark cytokine IFN-γ. Hence, SMAR1 plays an important role in modulating host immune response after M. tuberculosis infection. |
### Instruction:
Do both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell?
### Response:
| Both TLN-1 and TLN-2 levels correlate with tumorigenicity in human HCC, indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of HCC. |
### Instruction:
Does overexpression of CD61 promote hUC-MSC differentiation into male germ-like cells?
### Response:
| Under induction of BMP4, CD61-overexpressing hUC-MSCs, which had turned into PGC-like cells, could be further differentiated into male germ-like cells. Thus, a simple and efficient approach to study male germ cell development by using hUC-MSCs has been established. |
### Instruction:
Does fine Mapping identify a New QTL for Brown Rice Rate in Rice ( Oryza Sativa L. )?
### Response:
| In the study, the qBRR-10 affected the BRR and was finally located to a region between two markers, P13 and P14. Two candidate genes were selected based on the expression difference between two parents, which facilitated the further cloning of the qBRR-10 gene and largely contributed to improve the grain yield and quality in rice. |
### Instruction:
Does oral acetate supplementation attenuate N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis?
### Response:
| The signature behavioral phenotypes induced by acute and chronic regimen of NMDA receptor antagonists seemed to be attenuated by GTA. This study thus provides a therapeutic paradigm of using dietary acetate supplement in psychiatric disorders. |
### Instruction:
Does overexpression of a brassinosteroid biosynthetic gene Dwarf enhance photosynthetic capacity through activation of Calvin cycle enzymes in tomato?
### Response:
| BR plays a role in the regulation of photosynthesis. BR can increase the photosynthetic capacity by inducing a reduced redox status that maintains the activation states of Calvin cycle enzymes. |
### Instruction:
Does miR-21 expression predict prognosis in diffuse large B-cell lymphoma?
### Response:
| The results of the present study suggested miR-21 expression level could be a novel potential biomarker for DLBCL prognosis. |
### Instruction:
Does microRNA-497 inhibit invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A?
### Response:
| Thus our results provide evidence that miR-497 might function as a metastasis suppressor in CRC. Targeting miR-497 may provide a strategy for blocking its metastasis. |
### Instruction:
Do zinc-modified nanopolymers improve the quality of resin-dentin bonded interfaces?
### Response:
| Infiltration of polymeric nanoparticles into demineralized dentin increased long-term bond strengths. Zinc-loaded nanoparticles facilitate dentin remineralization within the complete resin-dentin interface. |
### Instruction:
Does hospital-skilled nursing facility referral linkage reduce readmission rates among Medicare patients receiving major surgery?
### Response:
| The benefits of increased hospital-SNF linkage seem to include meaningful reductions in hospital readmission after surgery. Overall, a 10% increase in the proportion of surgical referrals to a particular SNF is estimated to decrease readmissions by 4%. This may impact hospital-SNF networks participating in risk-based reimbursement models. |
### Instruction:
Does monophasic Pulsed 200-μA Current promote Galvanotaxis With Polarization of Actin Filament and Integrin α2β1 in Human Dermal Fibroblasts?
### Response:
| The results show that 200 μA is an effective monophasic pulsed microcurrent intensity to promote migration toward the cathode, and this intensity could regulate polarization of migration-related intracellular factors in human dermal fibroblasts. |
### Instruction:
Does gene expression profiling reveal key genes and pathways related to the development of non-alcoholic fatty liver disease?
### Response:
| The identified DEGs (PRKCA, EGFR, CDC42, VEGFA), disturbed pathways (ribosome, ubiquitin mediated proteolysis, focal adhesion, Fc?R-mediated phagocytosis, etc.) and miRNAs (hsa-miR-330-3p, hsa-miR-126, etc.) might be closely related to NAFLD progression. These results might contribute to understanding NAFLD mechanism, conducting experimental researches, and designing clinical practices. |
### Instruction:
Is the dual specificity phosphatase 2 gene hypermethylated in human cancer and regulated by epigenetic mechanisms?
### Response:
| Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression. |
### Instruction:
Does retinal Ganglion Cell Loss precede Retinal Nerve Fiber Thinning in Nonarteritic Anterior Ischemic Optic Neuropathy?
### Response:
| Thinning of the GCIPL is first detectable at 1 month after NAION and persists for 3 months. GCIPL thinning occurs before RFNL thinning in NAION. |
### Instruction:
Does thrombelastography detect dabigatran at therapeutic concentrations in vitro to the same extent as gold-standard tests?
### Response:
| The whole blood viscoelastic assay TEG R displayed linearity towards fixed concentrations of dabigatran and correlated strongly to the current gold-standard tests Hemoclot and ECT, for assessing dabigatran. TEG R is applicable as a rapid and precise whole blood monitoring test for dabigatran treated patients in the emergency setting. |
### Instruction:
Is ultrarush schedule of subcutaneous immunotherapy with modified allergen extracts safe in paediatric age?
### Response:
| The ultrarush protocol, without premedication, was a safe alternative to be used in paediatric age during the induction phase of subcutaneous immunotherapy using allergoid depigmented extracts. |
### Instruction:
Does [ Architectural modernization of psychiatric hospitals influence the use of coercive measures ]?
### Response:
| Despite the limitations of the study design the results suggest that the architectural improvements reduced the application of coercive measures. It is speculated that the positive structural milieu enhanced the well-being of patients and staff and their social relations, which in turn prevented coercive measures. |
### Instruction:
Are physical Activity Level and Symptom Duration Associated After Concussion?
### Response:
| Results from this study indicate that physical activity after the injury may not be universally detrimental to the recovery of concussion symptoms. |
### Instruction:
Do prolonged but not short-duration blast waves elicit acute inflammation in a rodent model of primary blast limb trauma?
### Response:
| We report the development of a rodent model of primary blast limb trauma that is the first to highlight an important role played by blast wave duration and magnitude in initiating acute inflammatory response following limb injury in the absence of limb fracture or penetrating trauma. The combined biological and mechanical method developed can be used to further understand the complex effects of blast waves in a range of different tissues and organs in vivo. |
### Instruction:
Does signalling via the osteopontin and high mobility group box-1 axis drive the fibrogenic response to liver injury?
### Response:
| During liver fibrosis, the increase in OPN induces HMGB1, which acts as a downstream alarmin driving collagen-I synthesis in HSCs. |
### Instruction:
Is peripheral neuropathy a common manifestation of mitochondrial diseases : a single-centre experience?
### Response:
| In conclusion, peripheral involvement in MD is frequent even if often mild or asymptomatic. The correct identification and characterization of peripheral neuropathy through electrophysiological studies represents another tile in the challenge of MD diagnosis. |
### Instruction:
Is sCD48 anti-inflammatory in Staphylococcus aureus Enterotoxin B-induced eosinophilic inflammation?
### Response:
| SEB regulates CD48 dynamics on eosinophils. Our data indicate sCD48 as a SEB-induced 'decoy' receptor derived from eosinophil and therefore as a potential anti-inflammatory tool in S. aureus-induced eosinophil inflammation often associated with allergy. |
### Instruction:
Is polygenic risk for coronary artery disease associated with cognitive ability in older adults?
### Response:
| Increased polygenic risk for CAD is associated with lower cognitive ability in older adults. Common genetic variants may underlie some of the association between age-related cognitive decrements and the risk for CAD. |
### Instruction:
Is beta-cell function associated with carotid intima-media thickness independently of insulin resistance in healthy individuals?
### Response:
| Insulin secretion was associated with early carotid atherosclerosis in nondiabetic individuals, independently of other risk factors, including insulin sensitivity measured by the gold-standard method. |
### Instruction:
Is plasma B-type natriuretic peptide concentration independently associated with kidney function decline in Japanese patients with chronic kidney disease?
### Response:
| Higher BNP levels were associated with adverse renal outcomes, independent of cardiac structure and function, suggesting that BNP may be a useful biomarker for exploring factors associated with kidney disease progression. |
### Instruction:
Does combining Manual Lymph Drainage with Physical Exercise after Modified Radical Mastectomy Effectively prevent Upper Limb Lymphedema?
### Response:
| Self-MLD, in combination with physical exercise, is beneficial for breast cancer patients in preventing postmastectomy scar formation, upper limb lymphedema, and shoulder joint dysfunction. |
### Instruction:
Do resident PW1+ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension?
### Response:
| These results demonstrate the existence of a novel population of resident SMC progenitor cells expressing PW1 and participating in pulmonary hypertension-associated vascular remodeling. |
### Instruction:
Does nSun2 Deficiency protect Endothelium From Inflammation via mRNA Methylation of ICAM-1?
### Response:
| NSun2 upregulates the expression of ICAM-1 by methylating ICAM-1 mRNA. This regulatory process impacts on vascular inflammation and allograft arteriosclerosis. |
### Instruction:
Is complete resection of contrast-enhancing tumor volume associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial?
### Response:
| Surgery at first recurrence of GBM improves outcome if complete resection of contrast-enhancing tumor is achieved. |
### Instruction:
Does spatial variation of insecticide resistance in the dengue vector Aedes aegypti present unique vector control challenges?
### Response:
| The results from this study suggest that 3 years after switching chemical groups, deltamethrin resistance and a high frequency of kdr alleles persisted in Ae. aegypti populations. The spatial variation that was detected in both resistance phenotypes and genotypes has practical implications, both for vector control operations as well as insecticide resistance management strategies. |
### Instruction:
Does serum palmitoleate act as a lipokine in subjects at high cardiometabolic risk?
### Response:
| Our observational data supports a relationship between de novo lipogenesis-derived circulating palmitoleic acid (palmitoleate) and increased cardiometabolic risk. |
### Instruction:
Is leptin receptor signaling required for high-fat diet-induced atrophic gastritis in mice?
### Response:
| Together, these results suggest that activation of the leptin signaling pathway in the stomach is required to develop obesity-associated atrophic gastritis. |
### Instruction:
Does cross-cultural integration affect attitudes towards people with HIV/AIDS in Australia?
### Response:
| This study is the first to demonstrate the benefits afforded by an individualist culture, particularly for PLWHA. The article concludes with a discussion on the implications associated with these findings, particularly for researchers and practitioners within the health promotion field. |
### Instruction:
Is exercise Medicine™ : A pilot study linking primary care with community physical activity support?
### Response:
| EIM + participation significantly increased PA levels among participants, suggesting this approach significantly impacts the PA of inactive adults more than just EIM only. |
### Instruction:
Does reorganization of Motor Cortex by Vagus Nerve Stimulation require Cholinergic Innervation?
### Response:
| Together, these findings indicate that the NB is required for VNS-dependent enhancement of plasticity in the motor cortex and may provide insight into the mechanisms that underlie the benefits of VNS therapy. |
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