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### Instruction:
Does hIF-1α siRNA reduce retinal neovascularization in a mouse model of retinopathy of prematurity?
### Response:
| RNA interference targeting HIF-1α can effectively inhibit the retinal neovascularization of ROP. |
### Instruction:
Are concerns about covert HIV testing associated with delayed presentation in Ethiopian adults with suspected malaria : a cross-sectional study?
### Response:
| In adults living in central Ethiopia, the perception that HIV testing accompanied the investigation of suspected malaria was common. This is likely to impede presentation for early medical treatment in some areas and represents a reversible risk factor that deserves further study. |
### Instruction:
Does the extracellular matrix protein laminin-10 promote blood-brain barrier repair after hypoxia and inflammation in vitro?
### Response:
| Our data unravel new mechanisms of BBB dysfunction induced by hypoxia and inflammation and identify LM10 as a key ECM molecule involved in BBB repair after hypoxic injury and inflammation. |
### Instruction:
Does co-administration of cisplatin and curcumin alter mood-associated behaviors?
### Response:
| According to the results of the present study, we concluded that curcumin might be regarded as a safe adjuvant in cisplatin chemotherapy in terms of the mood-associated behaviors (Fig. 4, Ref. 41). |
### Instruction:
Does exercise improve hippocampal estrogen and spatial memory of ovariectomized rats?
### Response:
| Regular exercise increases hippocampal estrogen levels and improves spatial memory retention of ovariectomized rats (Tab. 1, Fig. 4, Ref. 53). |
### Instruction:
Do a Novel Mutation in DMD ( c.10797+5G > A ) Causes Becker Muscular Dystrophy Associated with Intellectual Disability?
### Response:
| Dystrophinopathy may be associated with predominantly cognitive impairment and neurobehavioral disorder, and should be considered in the differential diagnosis of unexplained cognitive or psychiatric disturbance in males. |
### Instruction:
Does overexpression of HMGA2 promote tongue cancer metastasis through EMT pathway?
### Response:
| Our findings demonstrate that HMGA2 promotes TSCC invasion and metastasis; additionally, HMGA2 is an independent prognostic factor which implied that HMGA2 can be a biomarker both for prognosis and therapeutic target of TSCC. |
### Instruction:
Does albumin expression distinguish bile duct adenomas from metastatic adenocarcinoma?
### Response:
| Diagnostically challenging examples of bile duct adenoma may be distinguished from metastatic pancreatic adenocarcinoma by the use of albumin bISH. |
### Instruction:
Are grey matter brain injuries common in Ugandan children with cerebral palsy suggesting a perinatal aetiology in full-term infants?
### Response:
| Brain imaging patterns in this group of CP children differed markedly from imaging studies reported from high income countries, suggesting a perinatal aetiology in full-term infants and reduced survival in preterm infants. |
### Instruction:
Does hIF-2α promote epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer?
### Response:
| These findings indicated that HIF-2α promotes EMT in pancreatic cancer by regulating Twist2 binding to the promoter of E-cadherin, which meant that HIF-2α and this pathway may be effective therapeutic targets for pancreatic cancer. |
### Instruction:
Is reduced withdrawal and failure rates of accelerated nursing students enrolled in pharmacology associated with a supportive intervention?
### Response:
| The accelerated international and domestic graduate nursing students have low withdrawal rates and high success rates in a pharmacology course. However, domestic students with non-university qualifications have higher withdrawal and failure rates than other nursing students and may be underprepared for university study in pharmacology in nursing programs. The introduction of an intervention was associated with reduced withdrawal and failure rates for these students in the pharmacology course. |
### Instruction:
Does central proopiomelanocortin but not neuropeptide Y mediate sympathoexcitation and hypertension in fat fed conscious rabbits?
### Response:
| These findings suggest that obesity-induced hypertension and increased RSNA are dependent on the balance between greater activation of melanocortin signalling through melanocortin receptors and lesser activation of NPY sympathoinhibitory signalling. The amplification of the sympathoexcitatory effects of α-melanocortin stimulating hormone also indicates that the underlying mechanism is related to facilitation of leptin-melanocortin signalling, possibly involving chronic activation of brain-derived neurotrophic factor. |
### Instruction:
Is a stop-codon of the phosphodiesterase 11A gene associated with elevated blood pressure and measures of obesity?
### Response:
| One percent of the Swedish population carries a PDE11A loss-of-function mutation associated with elevated BP, abdominal obesity, and risk of ischemic stroke. |
### Instruction:
Does psychological Stress activate the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor?
### Response:
| These findings demonstrate that psychological "stress" is sensed by the innate immune system in the brain via the ATP/P2X7R-NLRP3 inflammasome cascade, and they identify novel therapeutic targets for the treatment of stress-related mood disorders and comorbid illnesses. |
### Instruction:
Is the cardiovascular and hypothalamus-pituitary-adrenal axis response to stress controlled by glucocorticoid receptor sequence variants and promoter methylation?
### Response:
| This is one of the first studies linking epigenetic modifications of the GR promoter, receptor genotype and physiological measures of the stress response. At baseline, there were clear genetic and epigenetic effects on blood pressure. The seCPT induced a strong cardiovascular and HPA axis response, and both systems were affected by the functional genetic variants, although methylation also predicted blood pressure reactivity. The return to baseline was predominantly influenced by the genomic sequence. Overall, the physiological response to the seCPT is controlled by an exquisite mix of genetic and epigenetic factors. |
### Instruction:
Does gREM1 be a Key Regulator of Synoviocyte Hyperplasia and Invasiveness?
### Response:
| GREM1 is highly expressed in RA joints, and functions as a regulator of survival, proliferation, migration, and invasion of RA-FLS. |
### Instruction:
Do evaluation of dental implant insertion torque using a manual ratchet?
### Response:
| Without the use of torque measuring devices, an average surgeon may achieve an average insertion torque of 63.26 + 6.8 Ncm. |
### Instruction:
Does behavior correlate of Post-Stroke Disability Using Data Mining and Infographics?
### Response:
| Data mining is promising to discover factors associated with post-stroke disability from a large population dataset. The findings can be potentially valuable for establishing the priorities for clinicians and researchers and for stroke patient education. The methods may generalize to other health conditions. |
### Instruction:
Is screen time associated with dietary intake in overweight Canadian children?
### Response:
| Screen time is associated with less desirable food choices, particularly in overweight children. |
### Instruction:
Does intensive lifestyle intervention including high-intensity interval training program improve insulin resistance and fasting plasma glucose in obese patients?
### Response:
| Following a 9-month intensive lifestyle intervention combining HIIT and MedD counseling, obese subjects experienced significant improvements of FPG and insulin resistance. This is the first study to expose the effects of a long-term program combining HIIT and MedD on glycemic control parameters among obese subjects. |
### Instruction:
Is mismatch repair deficiency in Lynch syndrome-associated colorectal adenomas more prevalent in older patients?
### Response:
| This study shows that MMR deficiency is associated significantly with increased age, in addition to two previously reported factors-larger size and high-grade dysplasia. When adenomas are analysed during LS screening, high sensitivity is expected if the adenomas are associated with any of these three factors. |
### Instruction:
Does cD49f promote proliferation of male dairy goat germline stem cells?
### Response:
| Taken together, our data suggest that CD49f plays novel and dynamic roles in regulating maintenance of pluripotency in mGSCs via Oct4 crosstalk and histone methylation dynamics,which may provide new solutions for mGSCs stability in vitro. |
### Instruction:
Does new approach to achieve high level enzyme production in Streptomyces lividans?
### Response:
| Streptomyces lividans is a frequently used platform for industrial enzyme production and a rational strain-development approach delivered significant improvement of protein production by this host. |
### Instruction:
Does fusion with stem cell make the hepatocellular carcinoma cells similar to liver tumor-initiating cells?
### Response:
| Fusion with stem cells transforms liver cancer cells into tumor initiating-like cells. Results indicate that fusion between cancer cell and stem cell may generate tumor initiating-like cells. |
### Instruction:
Does expression of HIF-1α and HIF-2α correlate to biological and clinical significance in papillary thyroid carcinoma?
### Response:
| Overexpression of HIF-1α and HIF-2α are associated with the carcinogenesis of PTC, served as potential biomarkers of PTC. |
### Instruction:
Does telomerase reverse transcriptase methylation predict lymph node metastasis and prognosis in patients with gastric cancer?
### Response:
| Our data suggested that hypermethylation of TERT promoter may contribute to gastric wall invasion, lymph node metastasis, lymphovascular/neural invasion, and poor prognosis in GC. GC patients with hypermethylation of TERT promoter could be eligible for close follow-up. |
### Instruction:
Does small interfering RNA expression inhibit avian infectious bronchitis virus replication and inflammatory response?
### Response:
| Small interfering RNA expression inhibits avian IBV replication and inflammatory response. |
### Instruction:
Does kIR2DL4 expression rather than its single nucleotide polymorphisms correlate with pre-eclampsia?
### Response:
| Decreased level of KIR2DL4 rather than its SNP is correlated with the susceptibility of pre-eclampsia. |
### Instruction:
Does amiloride suppress pilocarpine-induced seizures via ASICs other than NHE in rats?
### Response:
| Amiloride inhibited pilocarpine-induced SE and the anti-epileptic mechanism was associated with deactivation of the ASIC1a and ASIC3 instead of NHE in rats. |
### Instruction:
Does uric Acid-Induced Inflammation be Mediated by the Parathyroid Hormone:25-Hydroxyvitamin D Ratio in Obese Adolescents?
### Response:
| Hyperuricemia is strongly associated with PTH and hs-CRP levels independent of vitamin D status. The relationship between SUA and low-grade inflammation is mediated by the PTH:25(OH)D ratio in obese adolescents. |
### Instruction:
Do c-Myc and viral cofactor Kaposin B co-operate to elicit angiogenesis through modulating miRNome traits of endothelial cells?
### Response:
| Our study identifies known and novel c-Myc-regulated microRNAs and reveals that a c-Myc-oriented program is coordinated by Kaposin B in KSHV-infected cells. |
### Instruction:
Does curcumin attenuate high glucose-induced podocyte apoptosis by regulating functional connections between caveolin-1 phosphorylation and ROS?
### Response:
| Curcumin attenuates high glucose-induced podocyte apoptosis in vitro and diabetic nephropathy in vivo partly through regulating the functional connections between cav-1 phosphorylation and ROS. |
### Instruction:
Does admission serum lactate predict mortality in aneurysmal subarachnoid hemorrhage?
### Response:
| In aneurysmal SAH, elevated serum lactate levels on admission may have a predictive role for mortality and represent a marker of disease severity. Currently, lactic acid levels are not ordered on all patients with SAH but perhaps should be part of the routine initial blood work and may serve as an additional prognostic marker. |
### Instruction:
Is thulium laser enucleation of the prostate a safe and a highly effective modality for the treatment of benign prostatic hyperplasia - Our experience of 236 patients?
### Response:
| Thulium LASER is a safe and highly effective LASER in terms of blood loss, speed of tissue resection, drop in serum PSA, and versatility of prostatic resection. |
### Instruction:
Are neighborhood Characteristics Associated with Racial and Gender Variation in Walking among Older Adults : the Cardiovascular Health Study?
### Response:
| Female gender is more strongly associated with walking for African Americans than for Whites in low SES neighborhoods but had a similar association with walking for both African Americans and Whites in high SES neighborhoods. |
### Instruction:
Does the fibroblast Tiam1-osteopontin pathway modulate breast cancer invasion and metastasis?
### Response:
| These findings suggest a new therapeutic paradigm for preventing breast cancer metastasis. Pro-malignant signals from the tumor microenvironment with long-lasting effects on associated cancer cells may perpetuate the metastatic potential of developing cancers. Inhibition of these microenvironment signals represents a new therapeutic strategy against cancer metastasis that enables targeting of stromal cells with less genetic plasticity than associated cancer cells and opens new avenues for investigation of novel therapeutic targets and agents. |
### Instruction:
Does ruboxistaurin attenuate diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways?
### Response:
| These data suggest that the renoprotective effect of ruboxistaurin is possibly due to down-regulation of TGF-β1/Smad pathway and normalization of GRAP protein expression. |
### Instruction:
Does access to water provide economic relief through enhanced relationships in Kenya?
### Response:
| Access to water improved relationships, which encouraged economic growth. This information provides a critical component in understanding the interconnected nature between access to water, poverty and family relationships. Ultimately, this research suggests an increased need for access to quality water worldwide to improve both economic situations and relationships in low- and middle-income countries. |
### Instruction:
Do human endometrial regenerative cells attenuate renal ischemia reperfusion injury in mice?
### Response:
| This study demonstrates that the novel anti-inflammatory and immunoregulatory effects of ERCs are associated with attenuation of renal IRI, suggesting that the unique features of ERCs may make them a promising candidate for cell therapies in the treatment of ischemic acute kidney injury in patients. |
### Instruction:
Is diabetes an Important Risk Factor for Metastasis in Non- Muscle-Invasive Bladder Cancer?
### Response:
| Diabetic patients with non-muscle-invasive bladder cancer may suffer metastases earlier than expected although they are non invasive. Therefore such patients must be followed-up carefully and early cystectomy decision may be necessary. Further prospective studies with more patients are needed to confirm these findings. |
### Instruction:
Do enhanceosome transcription factors preferentially dimerize with high mobility group proteins?
### Response:
| It follows from our experiments that, except for homodimer formed by IRF proteins, the rest of the dimers were formed exclusively between one of the transcriptional activators (ATF-2/c-Jun and IRF) and a HMG I protein. NF- κB did not participate in forming dimers with other proteins. Dimers predicted in mouse were fully contained in those predicted in human, with exactly the same spacing and orientation. Intriguingly, in most of the cases the enhanceosome motifs have 1 bp wider spacing than the corresponding dimers predicted genome-wide, which is likely caused by the overall 3D structure constraints of the enhanceosome-bound complex. |
### Instruction:
Does watchful waiting as a treatment strategy for patients with a ventral hernia appear to be safe?
### Response:
| Watchful waiting appears to be a safe strategy in the treatment of incisional, umbilical and epigastric hernias. |
### Instruction:
Does artesunate demonstrate in vitro synergism with several antiviral agents against human cytomegalovirus?
### Response:
| These results suggest that the combination of ART with the antiviral agents tested in this study could be an interesting strategy for the treatment of HCMV infections to reduce toxicity and drug-resistance development. |
### Instruction:
Are non-responders in a quitline evaluation more likely to be smokers - a drop-out and long-term follow-up study of the Swedish National Tobacco Quitline?
### Response:
| Non-responders to a 12-month follow-up smoking cessation questionnaire in a quitline setting were more likely to be smokers 1.5-3 years later. We propose a conservative correction factor of 0.8 for self-reported abstinence in telephone-based cessation studies if the response rate is approximately 55-65 %. |
### Instruction:
Does reduced Antiviral Interferon Production in Poorly Controlled Asthma be Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids?
### Response:
| Antiviral type I IFN production is impaired in those with neutrophilic airway inflammation and in those prescribed high doses of inhaled corticosteroids. Our study is an important step toward identifying those with poorly controlled asthma who might respond best to inhaled IFN therapy during exacerbations. |
### Instruction:
Does c-Jun N-terminal kinase activation by nitrobenzoxadiazoles lead to late-stage autophagy inhibition?
### Response:
| Our demonstration that NBDs can act as late-phase autophagy inhibitors opens new opportunities to fully exploit their therapeutic potential. This may not rely solely on their effectiveness in inducing cell cycle arrest and apoptosis, but also on their ability to weaken the capacity of tumor cells to endure stress conditions via autophagy. In addition, this study provides evidence that JNK can participate in impairing autophagy. |
### Instruction:
Is calcium channel blocker use associated with lower fasting serum glucose among adults with diabetes from the REGARDS study?
### Response:
| CCB and in particular verapamil use was associated with lower fasting blood glucose levels among REGARDS participants with diabetes. |
### Instruction:
Does dexamethasone or Dexmedetomidine as Local Anesthetic Adjuvants for Ultrasound-guided Axillary Brachial Plexus block with Nerve Stimulation?
### Response:
| Dexamethasone 10 mg and dexmedetomidine 100 µg were equally effective in extending the duration of ropivacaine in ultrasound-guided axillary BPB with nerve stimulation. However, neither drug has significantly effects the onset time. |
### Instruction:
Does bicuspid aortic valve hemodynamics promote remodeling in porcine aortic wall concavity?
### Response:
| The hemodynamic stress environment present in the concavity of type-I LR-BAV AA does not cause any significant change in proteolytic enzyme expression and activity as compared to that present in the TAV AA. |
### Instruction:
Do radiographic technique and brackets affect measurements of proximal enamel thickness on mandibular incisors?
### Response:
| Angular changes in taking periapical radiographs of mandibular incisors and the presence of brackets significantly affect interproximal enamel measurements made with image analysis software. |
### Instruction:
Are school environmental factors predictive for exercise-induced symptoms in children?
### Response:
| This study showed an effect of cat allergen and environmental factors (humidity, air pressure) on the appearance of exercise related cough/bronchoconstriction during activity class in a natural environment at school in a large urban population of schoolchildren. |
### Instruction:
Is profile of oxidative stress markers dependent on vitamin D levels in patients with chronic hepatitis C?
### Response:
| Vitamin D insufficiency contributes to the inflammatory process and oxidative stress imbalance in patients with HCV. The profile of oxidative stress markers in these patients depends on vitamin D levels, which probably change intracellular signalling pathways and increase inflammation and liver injury. |
### Instruction:
Do fear of Movement and Low Self-Efficacy Are Important Barriers in Physical Activity after Renal Transplantation?
### Response:
| This study was the first to examine fear of movement and self-efficacy in relation to PA in RTR. Fear of movement was associated with a low PA level, and the larger part of this relation was mediated by low physical self-efficacy. Both fear of movement and physical self-efficacy level are important targets for intervention during rehabilitation after renal transplantation. |
### Instruction:
Does insulin stimulate Goose Liver Cell Growth by Activating PI3K-AKT-mTOR Signal Pathway?
### Response:
| These findings suggest that PI3K-Akt-mTOR pathway plays an essential role in insulin-regulated cell proliferation of goose hepatocyte. |
### Instruction:
Does bevacizumab specifically decrease elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients?
### Response:
| This pilot study provides evidence of systemic immunomodulatory effects of bevacizumab and identified circulating KIT+CD11b+ cells and IL-10 as candidate biomarkers of bevacizumab activity in metastatic breast cancer patients. |
### Instruction:
Does human Milk Analyser show that the lactation period affects protein levels in preterm breastmilk?
### Response:
| Variations in macronutrients were high in the breastmilk of women who delivered preterm babies and the protein content decreased with lactation. With adjustments, the MIRIS might provide a helpful tool for individualised fortification. |
### Instruction:
Does tNF-α and IL10 polymorphisms interaction increase the risk of ankylosing spondylitis in Chinese Han population?
### Response:
| IL10 rs1878672 and rs3024490 polymorphisms obviously increase the susceptibility to AS, but not TNF-α rs3093662. Both IL10 and TNF-α polymorphisms may affect the onset of AS. |
### Instruction:
Does the PTEN/Akt Signaling Pathway mediate Myocardial Apoptosis in Swine After Coronary Microembolization?
### Response:
| This study demonstrates, for the first time, that the PTEN/Akt signaling pathway contributes to cardiomyocyte apoptosis. The data generated from this study provide a rationale for the development of PTEN-based therapeutic strategies for CME-induced myocardial injury. |
### Instruction:
Does epidural analgesia increase the rate of inpatient falls after major upper abdominal and thoracic surgery : a retrospective case-control study?
### Response:
| Our study suggests that postoperative epidural analgesia for patients undergoing major upper abdominal and thoracic surgery is not associated with an increased risk of inpatient falls. |
### Instruction:
Is aCE-Inhibition Benefit on Lung Function in Heart Failure Modulated by ACE Insertion/Deletion Polymorphism?
### Response:
| ACE DD genotype is associated with higher vulnerability of the alveolar-capillary membrane to acute fluid overload in HF patients treated with ACE inhibitors. |
### Instruction:
Is the chronic damage in systemic lupus erythematosus driven by flares , glucocorticoids and antiphospholipid antibodies : results from a monocentric cohort?
### Response:
| In the present study chronic damage was identified in about one third of SLE patients. The association between SDI and the number of flares claim for a thigh-control of the disease activity in order to prevent the chronic damage. The possible role of antiphospholipid antibodies (aPL) in the development of neuropsychiatric and cardiovascular damage may suggest a more careful assessment of such aPL positive patients. |
### Instruction:
Is eRCP in potentially resectable malignant biliary obstruction frequently unsuccessful when performed outside of a comprehensive pancreaticobiliary center?
### Response:
| Patients who are candidates for pancreaticoduodenectomy frequently undergo ERCP. At a CMC, ERCP is often unsuccessful, is rarely accompanied by EUS, and often requires repeat endoscopy. Our findings support regionalizing the management of suspected pancreatic malignancy into dedicated specialty centers. J. Surg. Oncol. 2016;113:647-651. © 2016 Wiley Periodicals, Inc. |
### Instruction:
Are breakfast and fast food consumption associated with selected biomarkers in adolescents?
### Response:
| Breakfast and fast food consumption appear to be related to important metabolic syndrome biomarkers for chronic disease in a sample of healthy adolescents. The importance of this finding needs to be validated by examining the stability of this pattern over time and to assess the pattern in other populations. |
### Instruction:
Does aurora kinase targeting in lung cancer reduce KRAS-induced transformation?
### Response:
| Our results support our hypothesis that Aurora kinases are important KRAS targets in lung cancer and suggest Aurora kinase inhibition as a novel approach for KRAS-induced lung cancer therapy. |
### Instruction:
Does microRNA-133a inhibit Osteosarcoma Cells Proliferation and Invasion via Targeting IGF-1R?
### Response:
| MiR-133a suppresses osteosarcoma progression and metastasis by targeting IGF-1R in human osteosarcoma cells, providing a novel candidate prognostic factor and a potential anti-metastasis therapeutic target in osteosarcoma. |
### Instruction:
Does uNTREATED OBSTRUCTIVE SLEEP APNEA hinder RESPONSE TO BEVACIZUMAB IN AGE-RELATED MACULAR DEGENERATION?
### Response:
| Untreated OSA hinders the response of exudative AMD to intravitreal bevacizumab. Treatment of OSA with continuous positive airway pressure therapy yields a subsequent anatomical response and functional improvement while requiring significantly less injections. Identifying and treating underlying OSA earlier in patients with exudative AMD may yield better functional outcomes. |
### Instruction:
Do intrastromal corneal ring segments delay corneal grafting in patients with keratoconus?
### Response:
| ICRS implantation may be a surgical alternative to keratoplasty in patients with keratoconus. This procedure may delay or even eliminate the need for keratoplasty in such patients. |
### Instruction:
Do comparison of pain scores between patients undergoing panretinal photocoagulation using navigated or pattern scan laser systems?
### Response:
| Pain responses in patients undergoing PRP with a 30-ms pulse duration were significantly milder in the NAVILAS group than in the PASCAL group. |
### Instruction:
Does acute and chronic exposure to Tyrophagus putrescentiae induce allergic pulmonary response in a murine model?
### Response:
| Our data suggest that the intranasal exposure to Tp extract, with no systemic sensitization and no use of adjuvants, induces a robust allergic inflammation in the lungs of mice, in both acute and chronic models. Our Tp extract seems to be a potent allergen extract which may be used in asthma model studies. |
### Instruction:
Does the Escherichia coli yjfP Gene encode a Carboxylesterase Involved in Sugar Utilization during Diauxie?
### Response:
| Our results suggest that YjfP controls the intracellular concentration of acetyl sugars by redirecting them to the main metabolic circuits. Instead of detoxification, we propose that sugar acetylation is utilized by the cell for protection and to prevent the metabolism of a necessary minimal intracellular sugar pool. Those sugars can eventually be exported as a side effect of these mechanisms. |
### Instruction:
Does ability to detect high-grade squamous anal intraepithelial lesions at high resolution anoscopy improve over time?
### Response:
| The increase in ability to detect histological HSIL over time and with increasing experience has the potential to impact on delivery of clinical services and the interpretation of clinical trial data. Further studies are required to determine the extent of this effect on other clinicians practising HRA. |
### Instruction:
Does maraviroc-intensified combined antiretroviral therapy improve cognition in virally suppressed HIV-associated neurocognitive disorder?
### Response:
| This pilot study provides feasibility, tolerability, proof-of-concept and preliminary evidence for clinically relevant neurocognitive improvement in cART enhancement with maraviroc in virally suppressed HAND patients. Lack of concomitant brain metabolite and biomarker change may be related to complex dynamics of brain repair. |
### Instruction:
Does n30 Somatosensory Evoked Potential be Negatively Correlated with Motor Function in Parkinson 's Disease?
### Response:
| The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD. |
### Instruction:
Does undergoing Diagnostic Evaluation for Possible Cancer affect the Health-Related Quality of Life in Patients Presenting with Non-Specific Symptoms?
### Response:
| Patients with non-specific symptoms reported an affected HRQoL while undergoing a diagnostic evaluation for possible cancer. Morbidity, being unemployed and receiving a cancer diagnosis had the greatest effect on HRQoL around the time of diagnosis. |
### Instruction:
Do quantitative Alterations of Capillary Diameter Have a Predictive Value for Development of the Capillaroscopic Systemic Sclerosis Pattern?
### Response:
| The study showed that capillary diameter is an independent predictor for development of SSc-associated SRP. Progression to SRP is unlikely for subjects affected by RP when average capillary diameter is under 30 μm. Subsequently, the execution of the qualitative/quantitative integrated analysis should be part of the NVC followup of RP subjects. |
### Instruction:
Does computed Tomography Perfusion improve Diagnostic Accuracy in Acute Posterior Circulation Stroke?
### Response:
| Our findings in a large cohort of consecutive patients show that CTP detects significantly more ischemic strokes in the PC than CTA and NCCT alone. |
### Instruction:
Are unrecognized myocardial infarctions detected by cardiac magnetic resonance imaging associated with cardiac troponin I levels?
### Response:
| The independent association between levels of cTnI and UMI indicates a common pathophysiological pathway for the cTnI elevation and development of UMI. |
### Instruction:
Do pain and disability influence psychological and social factors at work among sick-listed patients with neck and back pain?
### Response:
| Sick-listed patients with neck and back pain who had concurrent anxiety or depression reported increased psychological and social challenges at work. To provide suitable treatment in the clinical setting, further attention should be paid to the interaction between anxiety or depression and perceived job strain. |
### Instruction:
Is hSPA6 an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL?
### Response:
| HSPA6 is a cigarette smoke-induced UC-susceptibility gene. The HSPA6 risk locus is associated with decreased HSPA6 expression. HSPA6 provides epithelial protection by stabilizing anti-apoptotic Bcl-XL, thereby contributing to the beneficial effect of cigarette smoking in UC. |
### Instruction:
Is downregulation of miR-129 in peripheral blood mononuclear cells a diagnostic and prognostic biomarker in prostate cancer?
### Response:
| Our results provide the first evidence that the miR-129 is significantly downregulated in prostate cancer patients and multivariate analysis confirmed that miR-129 is a novel independent prognostic factor for prostate cancer. Overexpression of miR-129 exerts tumor suppressive functions and abrogates prostate cancer growth. |
### Instruction:
Is untreated newly diagnosed essential hypertension associated with nonalcoholic fatty liver disease in a population of a hypertensive center?
### Response:
| Untreated, newly diagnosed essential HTN is independently associated with NAFLD. Ambulatory BP monitoring could be used for the diagnosis of essential HTN in patients with NAFLD. |
### Instruction:
Do anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis?
### Response:
| TNFα-dependent pathways control platelet activation and TF expression in RA. Further studies will verify whether the protective effect of TNFα inhibitors on cardiovascular events involves their ability to modulate platelet function. |
### Instruction:
Is apathy associated with poor prognosis in amyotrophic lateral sclerosis?
### Response:
| The presence of severe apathy is an independent, negative prognostic factor in ALS. |
### Instruction:
Does a null mutation in ANGPTL8 associate with either plasma glucose or type 2 diabetes in humans?
### Response:
| Disruption of ANGPTL8 function in humans does not seem to have a large effect on measures of glucose tolerance. |
### Instruction:
Does gene expression profiling identify candidate biomarkers for active and latent tuberculosis?
### Response:
| Our study demonstrated that gene expression profiles in the blood can be used to identify not only active TB patients, but also to differentiate latently infected patients from their healthy counterparts. Validation of the constructed computational model in a larger sample size would confirm the reliability of the biomarkers and facilitate the development of a cost-effective and sensitive molecular diagnostic platform for TB. |
### Instruction:
Does morroniside-Induced PP2A Activation antagonize Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration?
### Response:
| MOR attenuated OA-induced tau hyperphosphorylation via PP2A activation, and its mechanism might be related to the regulation of PP2Ac post-translational modification and upstream enzymes such as Src and PME-1. |
### Instruction:
Are histone H4 acetylation and the epigenetic reader Brd4 critical regulators of pluripotency in embryonic stem cells?
### Response:
| Together, our data demonstrate the fundamental role of Brd4 in monitoring cell differentiation through its interaction with acetylated histone marks and disruption of Brd4 may cause aberrant differentiation. |
### Instruction:
Does mirtazapine improve sleep disorders in Alzheimer 's disease : results from a double-blind , placebo-controlled pilot study?
### Response:
| This study showed no significant therapeutic effects of 15-mg mirtazapine in community-dwelling Alzheimer's disease patients with sleep disorders. Instead, this study found evidence of worsening of daytime sleep patterns. |
### Instruction:
Does tRPV6 play a new role in predicting survival of patients with esophageal squamous cell carcinoma?
### Response:
| TRPV6 is down-regulated in ESCC. As a predictive biomarker, TRPV6 plays a Janus-like role in predicting survival of male and female ESCC patients. |
### Instruction:
Do lung morphology assessment of cystic fibrosis using MRI with ultra-short echo time at submillimeter spatial resolution?
### Response:
| PETRA showed higher agreement in describing CF lung morphological changes than that of conventional sequences, whereas the Helbich-Bhalla scoring matched closely with that of CT. |
### Instruction:
Does analysis of the MIRIAD Data show Sex Differences in Hippocampal Atrophy Progression?
### Response:
| In the MIRIAD patients with probable AD, the HC atrophies at a significantly faster rate in women as compared to men. Female sex is a risk factor for faster descent into AD. The HI measure has potential for AD diagnosis, as a biomarker of AD progression and a therapeutic target in clinical trials. |
### Instruction:
Is the efficacy of fluticasone furoate administered in the morning or evening comparable in patients with persistent asthma?
### Response:
| AM and PM doses of once-daily FF 100 μg produced comparable improvements in lung function relative to placebo. |
### Instruction:
Does alcohol Drinking mediate the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma?
### Response:
| Polymorphisms on ADH1B and ALDH2 had significant indirect effects on hepatocellular carcinoma risk, mediated through alcohol drinking. |
### Instruction:
Does chemotherapy-Induced Fatigue correlate With Higher Fatigue Scores Before Treatment?
### Response:
| We conclude that fatigue induced by chemotherapy is common and consistently associated with higher fatigue scores before treatment. Screening for fatigue before chemotherapy may help to identify patients who are prone to develop CIF. |
### Instruction:
Does enzyme disintegration with spatial resolution reveal different distributions of sludge extracellular polymer substances?
### Response:
| Polygalacturonic acid-like matter hydrolysis caused significant release of polysaccharides. Polygalacturonase released polysaccharides while keeping proteins unreleased. Temperature and pH adjustment were as effective as enzyme at sludge disintegration. Cellulose hydrolysis led to massive release of all kinds of organic matters. A new conceptual sludge structure model regarding organic components is proposed. |
### Instruction:
Does critical Patient Severity Classification System predict outcomes in intensive care unit patients?
### Response:
| The CPSCS score can be used to efficiently predict ICU mortality and LOS in patients admitted to the medical and surgical ICUs, although only the high CPSCS score group had significantly high mortality than the low CPSCS score group in the medical ICU. |
### Instruction:
Does dexmedetomidine preconditioning inhibit the long term inflammation induced by renal ischemia/reperfusion injury in rats?
### Response:
| Dexmedetomidine has beneficial effects on long term inflammation induced by renal ischemia/reperfusion injury. Its mechanisms may be achieved through inhibiting the HMGB1/TLR4 pathway to exert protective effects. |
### Instruction:
Does remote limb ischemic post-conditioning attenuate ischemia-reperfusion injury in rat skin flapby limiting oxidative stress?
### Response:
| Three cycles of 5-min Limb remote ischemic post-conditioning rather than a single cycle of 15-min limb RIPoC has protective effect on flaps against ischemia-reperfusion injury by attenuating oxidative stress. |
### Instruction:
Does extraction of chronically implanted coronary sinus lead active fixation vs passive fixation leads?
### Response:
| In this largest study of CS lead extractions published to date, the overall success rate of the extraction of chronically implanted CS leads is high and the complication rate is similar in these lead models. The extraction of the model 4195 lead is clearly more challenging, but it can be accomplished in high-volume extraction centers with experienced operators. It is recommended that the model 4195 lead be extracted by experienced operators. |
### Instruction:
Is [ Diagnosis and treatment in patients with B-cell lymphoma unclassified that intermediate between diffuse large B-cell lymphoma and Burkitt 's lymphoma ]?
### Response:
| In the DHL group, both OS and EFS are significantly lower (the risk of poor outcome, including death, is higher) than those in the non-DHL group. It is conceivable that intensified chemotherapy with auto-SCT increases treatment results in patients with BCLU; however, a larger number of observations are needed to obtain valid data. |
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