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### Instruction:
Is higher augmentation index associated with tension-type headache and migraine in middle-aged/older humans with obesity?
### Response:
| Increased aortic AI but not stiffness is associated with TTH and migraine among middle-aged/older adults with obesity and high CVD risk. |
### Instruction:
Is vEGF-C expression a prognostic factor in locally advanced colon adenocarcinoma?
### Response:
| The study results indicate that expression of VEGF-C in cells of locally advanced pT3-4 adenocarcinoma of the colon does not affect the survival time of the patients. Increased expression of VEGF-C is accompanied by a significant increase in vessel density in the pT3-4 tumour stroma. Increased expression of VEGF-C in cancer cells is related to the tumour location in the left side of the colon and better tumour differentiation. |
### Instruction:
Does n-Acetylcysteine Amide protect Against Oxidative Stress-Induced Microparticle Release From Human Retinal Pigment Epithelial Cells?
### Response:
| This is the first evidence that oxidative stress induces cultured human RPE cells to release MPs that carry mCRPs on their surface. The levels of released MPs are strongly correlated with RPE apoptosis. N-acetylcysteine amide prevents oxidative stress-induced effects. Our findings indicate that oxidative stress reduces mCRPs on the RPE surface through releasing MPs. |
### Instruction:
Does duration of Posttraumatic Amnesia predict Neuropsychological and Global Outcome in Complicated Mild Traumatic Brain Injury?
### Response:
| Findings reinforce importance of careful measurement of duration of PTA to refine outcome prediction and allocation of resources to those with cmTBI. Future research would benefit from standardization in computed tomographic criteria and use of severity indices beyond Glasgow Coma Scale to characterize cmTBI. |
### Instruction:
Does neuropathogenicity of Two Saffold Virus Type 3 isolate in Mouse Models?
### Response:
| Both SAFV-3 isolates had neurotropism and mild neurovirulence but showed different cell tropisms in both neonatal and young mouse models. This animal model has the potential to recapitulate the potential neuropathogenicity of SAFV-3. |
### Instruction:
Does exacerbation of headache during dihydroergotamine for chronic migraine alter outcome?
### Response:
| After controlling for nausea and other factors, headache exacerbation with DHE infusions is not an independent predictor of poor headache outcome and clinicians should not interpret its presence as a reason to stop treatment. The focus of management should be on controlling nausea as it is the most important modifiable factor in achieving a good headache outcome with an inpatient course of IV DHE for chronic migraine. |
### Instruction:
Do reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury?
### Response:
| Taken together, these results reveal that after SCI, reactive astrocytes undergo M1 microglia/macrophages-induced necroptosis, partially through TLR/MyD88 signaling, and suggest that inhibiting astrocytic necroptosis may be beneficial for preventing secondary SCI. |
### Instruction:
Does high cost enhance cooperation through the interplay between evolution and self-organisation?
### Response:
| An emergent feedback between evolution and self-organisation leads to high degrees of cooperation at high costs, under simple and general conditions. We propose this as a general explanation for the evolution of cooperative behaviours under seemingly prohibitive conditions. |
### Instruction:
Does aminoacyl-Transfer RNA Synthetase Deficiency promote Angiogenesis via the Unfolded Protein Response Pathway?
### Response:
| Our results suggest that endoplasmic reticulum stress acts as a proangiogenic signal via unfolded protein response pathway-dependent upregulation of vegfaa. |
### Instruction:
Do [ Effects of inward rectifier potassium channel blockers on EPCs function ]?
### Response:
| Ba2+ and Cs+ play important roles in increasing EPCs functions, such as adhesion, migration and secretion. |
### Instruction:
Does pharmacologic blockade and genetic deletion of androgen receptor attenuate aortic aneurysm formation?
### Response:
| Pharmacologic and genetic AR blockade cause attenuation of AAA formation. Therapies for AR blockade used in prostate cancer may provide medical treatment to halt progression of AAAs in humans. |
### Instruction:
Do endoscopic and Laparoscopic Full-Thickness Resection of Endophytic Gastric Submucosal Tumors Very Close to the Esophagogastric Junction?
### Response:
| ELFR with laparoscopic two-layer suturing is a safe treatment option for patients with an SMT close to the EGJ, as major resection of the stomach is avoided. |
### Instruction:
Does helicobacter pylori Eradication reduce the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process?
### Response:
| Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation. |
### Instruction:
Do skills retention in Sudanese village midwives 1 year following Helping Babies Breathe training?
### Response:
| VMWs, despite a high illiteracy rate, absorbed and sustained HBB skills for at least a year. Regular, low intensity, manikin-based skills training with peers may have helped sustain FMV, but not hand-cleansing skills. |
### Instruction:
Does microRNA 429 regulate Mucin Gene Expression and Secretion in Murine Model of Colitis?
### Response:
| Our findings suggest that MIR429 modulates mucin secretion in human colorectal cells and mouse colitis tissues by up-regulating of MARCKS expression, thereby making MIR429 a candidate for anti-colitis therapy in human UC. |
### Instruction:
Are apolipoprotein E ε4 allele and malondialdehyde level independent risk factors for Alzheimer 's disease?
### Response:
| The presence of ε4 allele and elevated malondialdehyde levels are independent risk factors for Alzheimer's disease. These findings support the hypothesis that lipid peroxidation and ε4 allele contribute to the pathogenic cascade in Alzheimer's disease by different pathways. |
### Instruction:
Does prevalence and correlate of sleep problems among elderly Singaporeans?
### Response:
| The high probability of comorbid chronic conditions as well as higher disability among those with sleep problems makes this an important area of research. |
### Instruction:
Does the morphology of high frequency oscillations ( HFO ) improve delineating the epileptogenic zone?
### Response:
| HFO types 1 and 2 similarly reflect epileptogenicity. |
### Instruction:
Does prevalence and correlate of cell phone use among Texas drivers?
### Response:
| Despite its dangers, CPU remains popular among Texas drivers. CPU and texting bans should target public health campaigns towards female and younger drivers. |
### Instruction:
Do prepartum and Postpartum Maternal Depressive Symptoms Are Related to Children 's Brain Structure in Preschool?
### Response:
| Higher maternal depressive symptoms prenatally and postpartum are associated with altered gray matter structure in children; the observed white matter correlations appear to be uniquely related to the postpartum period. The reduced thickness and diffusivity suggest premature brain development in children exposed to higher maternal perinatal depressive symptoms. These results highlight the importance of ensuring optimal women's mental health throughout the perinatal period, because maternal depressive symptoms appear to increase children's vulnerability to nonoptimal brain development. |
### Instruction:
Do substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation?
### Response:
| We propose that the increases in the serum activin A, B and follistatin result from a combination of factors; the acute phase response, the reperfusion response and the use of heparin-based anti-coagulants. |
### Instruction:
Are permeation thresholds for hydrophilic small biomolecules across microvascular and epithelial barriers predictable on basis of conserved biophysical properties?
### Response:
| In silico modeling reveals that permeation thresholds, of small molecule hydrophiles, cations and anions across junctional pore complexes, are conserved in the physiologic state. |
### Instruction:
Does cHADS2 score predict risk of contrast-induced nephropathy in stable coronary artery disease patients undergoing percutaneous coronary interventions?
### Response:
| CHADS2 score could be a simple and useful predictor for CIN in patients undergoing elective PCI. |
### Instruction:
Is dynamic Change of Total Bilirubin after Portal Vein Embolization Predictive of Major Complications and Posthepatectomy Mortality in Patients with Hilar Cholangiocarcinoma?
### Response:
| Patients with increased total bilirubin in 5-14 days after PVE may indicate a higher risk of major complications and 30-day mortality if the major hepatectomy were performed. |
### Instruction:
Does lipofilling of the Breast Increase the Risk of Recurrence of Breast Cancer : A Matched Controlled Study?
### Response:
| The study results showed no increase in locoregional recurrence, systemic recurrence, or second breast cancer. These findings support the oncologic safety of lipofilling in breast reconstruction. |
### Instruction:
Does concurrent Risperidone Administration attenuate the Development of Locomotor Sensitization Following Sub-Chronic Phencyclidine in Rats?
### Response:
| These results demonstrate that concurrent risperidone is neuroprotective, and clearly suggests its functionality can be translated to a clinical setting for treating the so-called prodrome. |
### Instruction:
Does doxycycline protect Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis?
### Response:
| Dox exerts an anti-apoptosis function via the NF-κB-Bcl-2/Bax and Trx2-ASK1/JNK pathways in vitro. Therefore, Dox may represent a drug that could be used to attenuate thymic senescence, rescue thymic function, and promote T cell reconstitution. |
### Instruction:
Does solifenacin and Tamsulosin Combination Therapy decrease Urine Nerve Growth Factor/Creatinine Levels in Men?
### Response:
| Male patients with LUTS had decreased urinary NGF/Cr levels after treatment with combination solifenacin and tamsulosin in this novel pilot study. This corresponded with improvement in patient reported outcomes. |
### Instruction:
Do changes in social support predict emotional well-being in breast cancer survivors?
### Response:
| This study highlights the decline in social support among recently treated female breast cancer survivors and the importance of maintaining high-quality social support for emotional well-being. Copyright © 2016 John Wiley & Sons, Ltd. |
### Instruction:
Are ratios of central venous-to-arterial carbon dioxide content or tension to arteriovenous oxygen content better markers of global anaerobic metabolism than lactate in septic shock patients?
### Response:
| ∆ContCO2/∆ContO2 and ∆PCO2/∆ContO2 ratios are more reliable markers of global anaerobic metabolism than lactate. ScvO2 failed to predict the presence of global tissue hypoxia. |
### Instruction:
Does autologous cytokine-induced killer cell transfusion increase overall survival in advanced pancreatic cancer?
### Response:
| These results from this retrospective analysis appeared to imply that CBT might prolong survival in these high-risk PC patients. Prospective study is needed to corroborate this observation. |
### Instruction:
Does thrombus Permeability be Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke?
### Response:
| This study shows that simultaneous measurement of thrombus attenuation in noncontrast computed tomography and computed tomographic angiography allows for quantification of thrombus perviousness. Thrombus perviousness is strongly associated with improved functional outcome, smaller final infarct volume, and higher recanalization rate. |
### Instruction:
Does aspirin reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms : an analysis of the EMPHASIS-HF study?
### Response:
| Aspirin use in patients with chronic systolic heart failure and mild symptoms did not substantially reduce the overall beneficial effects of the MRA eplerenone contrary to what has been described in some studies with ACE inhibitors. |
### Instruction:
Is treatment of fecal retention important in the management of overactive bladder in children?
### Response:
| Investigation of fecal retention with the Leech scoring system and laxative treatment might be helpful in the management of OAB in children. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc. |
### Instruction:
Do methylenetetrahydrofolate reductase polymorphisms at 3'-untranslated region are associated with susceptibility to preterm birth?
### Response:
| In conclusion, rs1537515 and rs1537516 within the 3'-UTR of the MTHFR gene may be associated with susceptibility to PTB. |
### Instruction:
Does low Fecal Calprotectin correlate with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn 's Disease?
### Response:
| Low FC correlates well with histological remission and mucosal healing in colonic inflammatory bowel disease and is thus a clinically useful surrogate for inflammatory activity. |
### Instruction:
Does miR-130a-3p regulate cell migration and invasion via inhibition of Smad4 in gemcitabine resistant hepatoma cells?
### Response:
| Our findings provide a molecular insight on understanding drug resistance in HCC cells. Therefore, activation of miR-130a-3p or inactivation of Smad4 could be a novel approach for the treatment of HCC. |
### Instruction:
Does exome sequencing identify a mutation in TMC1 as a novel cause of autosomal recessive nonsyndromic hearing loss?
### Response:
| We found a new missense mutation in the T5-T6 domain of TMC1, which is highly conserved in many species. These data support the potential conserved role of p.P660L in human TMC1 function. |
### Instruction:
Does post-thaw ATP supplementation enhance cryoprotective effect of iodixanol in rat spermatozoa?
### Response:
| Iodixanol has cryoprotective effects during rat sperm freezing without any toxic effect. Moreover, the combinations of iodixanol and ATP have a beneficial role in maintaining function of frozen-thawed rat spermatozoa for long period of incubation post-thaw. |
### Instruction:
Does xanthohumol inhibit cellular proliferation in a breast cancer cell line ( MDA-MB231 ) through an intrinsic mitochondrial-dependent pathway?
### Response:
| Xanthohumol inhibited the proliferation of MDA-MB-231 cells through a mitochondria- and caspase-dependent apoptotic pathway. This result suggests that xanthohumol might serve as a novel therapeutic drug for breast cancer. |
### Instruction:
Does [ Autophagy inhibitor 3-methyladenine enhance the sensitivity of nasopharyngeal carcinoma cells to chemotherapy and radiotherapy ]?
### Response:
| 3-MA can sensitize HONE-1 cells to chemotherapy and radiotherapy, which is related to prevention of endoplasmic reticulum stress-induced autophagy in nasopharyngeal carcinoma cells. |
### Instruction:
Does early Vasospasm after Aneurysmal Subarachnoid Hemorrhage predict the Occurrence and Severity of Symptomatic Vasospasm and Delayed Cerebral Ischemia?
### Response:
| In view of the strong correlation with delayed symptomatic vasospasm and its ischemic complications, EAVS can be considered an alerting signal for severe symptomatic vasospasm. Therefore, more attention should be paid to the presence of EAVS on admission DSA. |
### Instruction:
Are pancreatic polypeptide and its central Y4 receptors essential for cued fear extinction and permanent suppression of fear?
### Response:
| Our findings suggests suppression of excessive arousal as a possible mechanism for the extinction-promoting effect of central Y4 receptors and provide strong evidence that fear extinction requires integration of vegetative stimuli with cortical and subcortical information, a process crucially depending on Y4 receptors. Importantly, in the lateral hypothalamus two peptide systems, PP and orexin, interact to generate an emotional response adapted to the current homeostatic state. Detailed investigations of feeding-relevant genes may thus deliver multiple intervention points for treating anxiety-related disorders. |
### Instruction:
Does serotonin promote exploitation in complex environments by accelerating decision-making?
### Response:
| Our results implicate 5-HT in a novel form of decision-making, demonstrate its fitness consequences, suggest that NSM and ADF act in concert to modulate locomotion in complex environments, and identify the synergistic action of a channel and a metabotropic receptor in accelerating C. elegans decision-making. |
### Instruction:
Does behavioral Pure-Tone Threshold shift Caused by Tympanic Membrane Electrodes?
### Response:
| Low-frequency threshold shifts occur when using TM electrodes and insert earphones. These findings are relevant to interpreting electrocochleographic responses to low-frequency stimuli. |
### Instruction:
Do selective Cannabinoid Receptor-1 Agonists Regulate Mast Cell Activation in an Oxazolone-Induced Atopic Dermatitis Model?
### Response:
| Our results indicate that CB1R agonists down-regulate mast cell activation and may be used for relieving inflammatory symptoms mediated by mast cell activation, such as atopic dermatitis, psoriasis, and contact dermatitis. |
### Instruction:
Is interaction of Wnt5a with Notch1 Critical for the Pathogenesis of Psoriasis?
### Response:
| Our data suggest that Wnt5a and Notch1 signaling exert counteracting influences on each other and are involved, in part, in the pathomechanism of psoriasis. |
### Instruction:
Do intubated Trauma Patients Require Full Trauma Team Activation when Effectively Triaged?
### Response:
| When appropriately triaged, selected intubated trauma patients do not require full trauma activation to receive timely, efficient care. |
### Instruction:
Does h3K4 tri-methylation breadth at transcription start sites impact the transcriptome of systemic lupus erythematosus?
### Response:
| We identified the immediate TSS downstream nucleosome as a crucial regulator responsible for transcription changes in SLE. This study applied a unique method to study the effect of H3K4me3 breadth on diseases and revealed new insights about epigenetic modifications in SLE, which could lead to novel treatments. |
### Instruction:
Does prevalence and correlate of Disruptive Mood Dysregulation Disorder Among Adolescents with Bipolar Disorder?
### Response:
| Despite the positioning of DMDD as phenotypically and biologically distinct from BD, these phenotypes commonly overlap in clinical settings. This overlap is not explained by BD-NOS or by nonfamilial BD. The association of ADHD with DMDDP in this sample draws into question whether arousal symptoms should have been retained as originally elaborated in the severe mood dysregulation phenotype. Strategies to mitigate the excessive functional impairment of this comorbidity are warranted. |
### Instruction:
Does mechanical Dispersion Assessed by Strain Echocardiography be Associated with Malignant Arrhythmias in Chagas Cardiomyopathy?
### Response:
| GLS and MD may add important information in the risk stratification of patients with ChD. The use of MD by strain echocardiography could be an attractive tool in the decision making for ICD placement as primary prevention for sudden cardiac death in patients with ChD. |
### Instruction:
Does increased pain relief with remifentanil improve the success rate of external cephalic version : a randomized controlled trial?
### Response:
| Remifentanil for analgesia decreased external cephalic version-related pain but did not increase the success rate of external cephalic version at term and appeared to be associated with an increased frequency of mild adverse effects. |
### Instruction:
Does over-Expression of CD200 protect Mice from Dextran Sodium Sulfate Induced Colitis?
### Response:
| The CD200:CD200R axis plays an immunoregulatory role in control of DSS induced colitis in mice. |
### Instruction:
Does smad7 Knockdown restore Aryl Hydrocarbon Receptor-mediated Protective Signals in the Gut?
### Response:
| The inverse correlation between Smad7 and AhR expression helps to propagate inflammatory signals in the gut. |
### Instruction:
Does measurement of fecal elastase improve performance of newborn screening for cystic fibrosis?
### Response:
| The algorithm for the diagnostic part of the newborn screening used in the CF centers is important and affects the performance of a CF-NBS program with regard to the ratio CF:CFSPID and the time until definite diagnosis. Our results suggest to include FE after initial sweat test failure in the CF-NBS guidelines to keep the proportion of CFSPID low and the time until definite diagnosis short. |
### Instruction:
Do pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype?
### Response:
| Panx1 seems to play an important role in murine cardiac electrophysiology and warrants further consideration in the context of hereditary forms of atrial fibrillation. |
### Instruction:
Is mixed lineage kinase domain-like protein a prognostic biomarker for cervical squamous cell cancer?
### Response:
| MLKL was a prognostic biomarker for cervical squamous cell carcinoma. |
### Instruction:
Does androgen Deprivation Followed by Acute Androgen Stimulation Selectively sensitize AR-Positive Prostate Cancer Cells to Ionizing Radiation?
### Response:
| These results suggest a potential cooperative effect and improved tumor growth delay with androgen-induced DSBs and radiation with implications for improving the therapeutic index of prostate cancer radiation therapy. Clin Cancer Res; 22(13); 3310-9. ©2016 AACRSee related commentary by Chua and Bristow, p. 3124. |
### Instruction:
Do population structure and associated phenotypes of Salmonella enterica serovars Derby and Mbandaka overlap with host range?
### Response:
| The results of this study lend support to the hypothesis that the differences in host ranges of S. Derby and S. Mbandaka are adaptations to pathogenesis, environmental persistence, as well as utilisation of metabolites abundant in their respective host environments. |
### Instruction:
Does percutaneous Coronary Intervention be More Beneficial Than Optimal Medical Therapy in Elderly Patients with Angina Pectoris?
### Response:
| Elective PCI reduced major adverse events and was found to be an effective treatment modality in elderly patients with angina pectoris and significant coronary artery stenosis, compared to OMT. |
### Instruction:
Do high BMI and low HDL-C predict the chemotherapy-related hepatic dysfunction in Chinese advanced NSCLC patients?
### Response:
| Higher BMI and lower HDL-C levels seem to be good independent predictive factors for chemotherapy-related hepatic dysfunction in advanced NSCLC. In addition, a negative correlation was presented between BMI and HDL-C. |
### Instruction:
Is hypermethylation of CpG sites at the promoter region associated with deregulation of mitochondrial ATPsyn-β and chemoresistance in acute myeloid leukemia?
### Response:
| Hypermethylation of ATPsyn-β gene promoter is associated with a down-regulated mRNA expression and chemoresistance in AML patients. |
### Instruction:
Does nur77-mediated TRAF6 signalling protect against LPS-induced sepsis in mice?
### Response:
| These in vivo observations reveals an important protective role for Nur77 in LPS-induced sepsis through its regulation to TRAF6 signalling, and highlights the potential clinical application of Nur77 as a molecular target in prevention and/or treatment of sepsis. |
### Instruction:
Does human herpesvirus 8 establish a latent infection in prostates of Tobago men resulting in increased macrophage infiltration?
### Response:
| HHV-8 establishes a chronic latent infection in the prostate, which is associated with an increased macrophage infiltrate. |
### Instruction:
Is muscle Quality More Impaired in Sarcopenic Patients With Chronic Obstructive Pulmonary Disease?
### Response:
| Type I muscle fiber proportion is lower in sarcopenic compared with nonsarcopenic patients with COPD. Longitudinal studies may elucidate if the loss of muscle oxidative phenotype drives or accelerates the process of muscle wasting. |
### Instruction:
Do wake-up Strokes Are Similar to Known-Onset Morning Strokes in Severity and Outcome?
### Response:
| While patients with wake-up stroke were similar to patients with known-onset morning stroke in many respects, patients with known onset morning stroke were significantly more likely to get treated with thrombolytic therapy and have higher in-hospital mortality. |
### Instruction:
Is whole-exome sequencing a powerful approach for establishing the etiological diagnosis in patients with intellectual disability and microcephaly?
### Response:
| We demonstrate that whole-exome sequencing is a powerful tool for the diagnostic evaluation of patients with highly heterogeneous neurodevelopmental disorders such as intellectual disability with microcephaly. Our results confirm that autosomal recessive disorders are highly prevalent among patients with microcephaly. |
### Instruction:
Does gualou Xiebai decoction inhibit cardiac dysfunction and inflammation in cardiac fibrosis rats?
### Response:
| Treatment with GXD improved cardiac function induced by myocardial fibrosis by inhibiting expression of inflammatory mediators associated with NF-κB. |
### Instruction:
Does blockade of Tim-1 and Tim-4 enhance Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice?
### Response:
| Blockade of Tim-4 aggravates atherosclerosis likely by prevention of phagocytosis of phosphatidylserine-expressing apoptotic cells and activated T cells by Tim-4-expressing cells, whereas Tim-1-associated effects on atherosclerosis are related to changes in Th1/Th2 balance and reduced circulating regulatory T cells. |
### Instruction:
Do extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation?
### Response:
| These studies establish a general inhibitory effect of EV on endothelial cell proangiogenic responses and identify a CD36-mediated mechanistic pathway through which EV inhibit MVEC migration and tube formation. |
### Instruction:
Does questionnaire-based survey suggest that the majority of Danish geriatricians are against euthanasia?
### Response:
| The majority of Danish geriatricians are opposed to EU and PAS. |
### Instruction:
Are h2AX phosphorylation and DNA damage kinase activity dispensable for herpes simplex virus replication?
### Response:
| H2AX phosphorylation represents a cell type-specific and virus type-specific host response to HSV infection with little impact on viral infection. |
### Instruction:
Do symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease?
### Response:
| In an analysis of a large cohort of subjects with IBD, we found a significant association between symptoms of depression or anxiety and clinical recurrence. Patients with IBD should therefore be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment. |
### Instruction:
Does testosterone modulate endothelial progenitor cells in rat corpus cavernosum?
### Response:
| The EPC markers were expressed in the cavernosal sinusoidal endothelial space, and the numbers of resident EPCs were regulated by testosterone. These results suggest that testosterone replacement therapy may improve erectile function by modulating EPCs in patients with hypogonadism. |
### Instruction:
Is serum CETP concentration associated with measures of body fat : The NEO study?
### Response:
| In this population-based study, there was no evidence for clinically relevant associations between several measures of body fat and serum CETP concentration. This finding implies that adipose tissue does not contribute to the CETP pool in serum. |
### Instruction:
Is type I Interferon response in olfactory bulb , the site of tick-borne flavivirus accumulation , primarily regulated by IPS-1?
### Response:
| We show that LGTV replication is restricted to the olfactory bulb and that IPS-1 is a very important player in the olfactory bulb in shaping the innate immune response by inhibiting early viral replication and viral spread throughout the central nervous system. In the absence of IPS-1, higher viral replication leads to the evasion of antiviral response by inhibiting interferon signaling. Our data suggest that the local microenvironment of distinct brain regions is critical to determine virus permissiveness. |
### Instruction:
Do claudin-1 expressions decrease in pterygium with respect to normal conjunctiva?
### Response:
| The loss of claudin-1 appears to be involved in the pathogenesis of pterygium and the future studies will elucidate the exact role of tight junction proteins in the invasive and recurrent nature of pterygium. |
### Instruction:
Do a phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema?
### Response:
| Autologous MSC treatment in severe emphysema is feasible and safe. The increase in CD31 expression after LVRS and MSC treatment suggests responsiveness of microvascular endothelial cells in the most severely affected parts of the lung. |
### Instruction:
Is higher emotional intelligence related to lower test anxiety among students?
### Response:
| The pattern of results suggests that efforts to improve intrapersonal and interpersonal skills, and mood might benefit students with high TA. Specifically, social commitment might counteract TA. |
### Instruction:
Does echistatin prevent posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway?
### Response:
| Echistatin could inhibit postoperative PCO occurrence and development in diabetic rabbit eyes, which may be related to down-regulation the expression of ILK and inhibition the PI3-K/Akt and ERK1/2 pathways. |
### Instruction:
Is methylation-silencing RCC1 expression associated with tumorigenesis and depth of invasion in gastric cancer?
### Response:
| Our data indicate that RCC1 expression is frequently lost in poorly differentiated gastric cell lines and gastric carcinoma tissues. Loss of RCC1 expression is correlated with tumor differentiation and depth of invasion. These findings suggest that RCC1 may play a tumor suppressor role in gastric carcinoma. |
### Instruction:
Does insulin-like growth factor 1 have multisystem effects on foetal and preterm infant development?
### Response:
| There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants. |
### Instruction:
Does artemisinin protect mice against burn sepsis through inhibiting NLRP3 inflammasome activation?
### Response:
| Artemisinin protects mice from burn sepsis by attenuating the inflammatory response and alleviating inflammatory infiltration in vital organs, likely through inhibiting the activation of NLRP3 inflammasome. |
### Instruction:
Does gastric bypass significantly improve quality of life in morbidly obese patients with type 2 diabetes?
### Response:
| For the first time, with a prospective matched control study, we demonstrate a significant improvement in HRQOL in obese diabetic patients who underwent RYGB, but not in those who were offered standard medical therapy and DSE. |
### Instruction:
Is performance success or failure influenced by weeks lost to injury and illness in elite Australian track and field athletes : A 5-year prospective study?
### Response:
| Injuries and illnesses, and their influence on training availability, during preparation are major determinants of an athlete's chance of performance goal success or failure at the international level. |
### Instruction:
Are persistent Vascular Remodeling and Leakiness Important Components of the Pathobiology of Re-bleeding in Hemophilic Joints : Two Informative Cases?
### Response:
| Vascular remodeling contributes to perpetuated hemophilic joint bleeding and therefore contributes to progressive arthropathy. Intra-articular or systemic administration of anti-angiogenic drugs, such as vascular endothelial growth factor antagonists, might be of benefit in such patients, but requires study. |
### Instruction:
Do oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype?
### Response:
| Our study suggests that liver tumor phenotype is defined by a combination of driving oncogenes but also the nature of chronic liver inflammation. (Hepatology 2016;63:1888-1899). |
### Instruction:
Does trimetazidine alter metabolic substrate oxidation in cardiac mitochondria of target patient population?
### Response:
| Using myocardial tissue from CAD patients, we found that trimetazidine (applied chronically in vivo or acutely in vitro) had no effect on cardiac fatty acid and carbohydrate oxidation, suggesting that the clinical effects of trimetazidine are unlikely to be due to its metabolic effects, but rather to an as yet unidentified intracardiac mechanism. |
### Instruction:
Does the diversification of the basic leucine zipper family in eukaryotes correlate with the evolution of multicellularity?
### Response:
| Our results reveal the ancestral opisthokont, holozoan and metazoan bZIP repertoire and provide insights into the progressive expansion and divergence of bZIPs in the five main eukaryotic kingdoms, suggesting that the early diversification of bZIPs in multiple eukaryotic lineages was a prerequisite for the evolution of complex multicellular organisms. |
### Instruction:
Is prosthetic alignment after total knee replacement associated with dissatisfaction or change in Oxford Knee Score : A multivariable regression analysis?
### Response:
| Neither mechanical axis, nor component alignment, is associated with dissatisfaction at one year following TKR. Patients get the best outcome when pain reduction and function improvement are optimal during the first three months and when the indication to embark on surgery is based on physical limitations rather than on a high pain score. |
### Instruction:
Does an integrative genome-wide transcriptome reveal that candesartan is neuroprotective and a candidate therapeutic for Alzheimer 's disease?
### Response:
| Our data may be interpreted as evidence of direct candesartan neuroprotection beyond its effects on blood pressure, revealing common and novel disease mechanisms that may underlie the in vitro gene alterations reported here and glutamate-induced cell injury in Alzheimer's disease. Our observations provide novel evidence for candesartan neuroprotection through early molecular mechanisms of injury in Alzheimer's disease, supporting testing this compound in controlled clinical studies in the early stages of the illness. |
### Instruction:
Is cardiac hypertrophy exacerbated in aged mice lacking the osteoprotegerin gene?
### Response:
| These results suggest that OPG plays a role in preserving myocardial structure and function with ageing through a reduction in apoptosis and preservation of the matrix structure. In addition, this appears to be independent of effects on the vasculature. |
### Instruction:
Does selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impair myofilament function in Mybpc3-targeted HCM mouse model?
### Response:
| These data provide evidence that in the KI HCM mouse model, β-AR stimulation leads to preferential PKA phosphorylation of PLN over cTnI, resulting in an impaired inotropic and lusitropic response. |
### Instruction:
Do comorbidities Drive Outcomes for Both Malignancy-Associated and Non-Malignancy-Associated Hemophagocytic Syndrome?
### Response:
| Malignancy-associated HPS, CCI ≥ 2, age > 50 years, and Medicare patients were associated with a worse in-hospital mortality. In multivariate analysis, greater comorbidity burden appeared to be the single most important predictor of mortality. This suggests that outcomes for adults with HPS are predicated by the extent of organ dysfunction at diagnosis. |
### Instruction:
Is younger gestational age associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia?
### Response:
| Compared to term infants, not only preterm but also late preterm and near-term CDH children carry an increased risk of ND delays. Motor performance appears most susceptible to earlier delivery. |
### Instruction:
Is routine contrast enema required for all infants prior to ostomy reversal : A 10-year single-center experience?
### Response:
| Routine CE is not required prior to small bowel ostomy reversal in infants. We recommend judicious use of enema studies in patients with NEC and high likelihood of stricture. |
### Instruction:
Does mRI-DWI improve the early diagnosis of brain abscess induced by Candida albicans in preterm infants?
### Response:
| MRI-DWI and dynamic MRI changes can improve the early diagnosis of brain abscess induced by Candida albicans in preterm infants. |
### Instruction:
Is dLC-1 an independent prognostic marker and potential therapeutic target in hepatocellular cancer?
### Response:
| DLC1 could be served as a tumor suppressor gene in the progression especially in the invasion and metastasis of HCC. DLC1 perhaps played its role by regulating the expression of Rho A, ROCK2 and moesin. Evaluation of the expression of DLC-1 might be a good prognostic marker for patients with HCC. |
### Instruction:
Do pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis?
### Response:
| We conclude that the ultrastructure and function of fibroblasts and myofibroblasts are affected by pirfenidone and nintedanib. Combination of the drugs reduced cell proliferation more than either of them individually. Human lung derived cell culture systems represent a potential platform for screening and testing drugs for fibrotic diseases. |
### Instruction:
Is sGK1 modulated by resistin in vascular smooth muscle cells and in the aorta following diet-induced obesity?
### Response:
| These data suggest that high levels of resistin observed during obesity may activate SGK1 in the vasculature and contribute to the development of obesity-related vascular disease. |
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