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### Instruction:
Is the activation of the NF-κB-JNK pathway independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration?
### Response:
| This study sheds light on the mode of action of bFGF and identifies that the NF-κB-JNKs pathway is independent of the PI3K-JNKs pathway to accelerate fibroblast migration. In addition, bFGF and the relief of inflammation could be a favorable therapeutic approach for skin wound healing. |
### Instruction:
Does interleukin 20 regulate dendritic cell migration and expression of co-stimulatory molecules?
### Response:
| Taken together, our findings points to a possible, yet subtle, role of IL-20 in DCs migration. The biphasic response suggests that the aberrant IL-20 expression in psoriasis impedes DC migration, which could be a part of the processes that precipitates the dysregulated inflammatory response associated with this disease. |
### Instruction:
Does a1E reduce stemness and self-renewal in HPV 16-positive cervical cancer stem cells?
### Response:
| Taken together, A1E can inhibit CSCs and reduce the expression of stemness markers. Treating CSCs with A1E may be a potential therapy for cervical cancer. |
### Instruction:
Does simvastatin pretreatment enhance ischemia-induced neovascularization and blood flow recovery in streptozotocin-treated mice?
### Response:
| Simvastatin helped recover blood flow and reduce tissue damage in ischemic hindlimbs and also promoted new vessel formation in streptozotocin-treated mice, whereas ezetimibe did not. These results may help explain why statins and ezetimibe decrease cholesterol levels, whereas their pleiotropic effects on vasoprotective functions independent of low-density lipoprotein cholesterol lowering are different. |
### Instruction:
Does miR-320a mediate doxorubicin-induced cardiotoxicity by targeting VEGF signal pathway?
### Response:
| Our observations demonstrate that miR-320a play important roles in doxorubicin induced cardiotoxicity via vessel homeostasis in heart and thus, inhibition of miR-320a may be applied to the treatment of cardiac dysfunction induced by anthracycline. |
### Instruction:
Do right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients?
### Response:
| Long-term chronic migraine patients show abnormalities in anterior white matter tracts, particularly of the right hemisphere, involved in pain modulation emotion, cognition and resilience. Robustness in these areas is associated with a higher cognitive reserve, which in turn might result in a lower tendency to migraine chronification. |
### Instruction:
Does clofarabine have Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene Expression?
### Response:
| Our results showed that apoptotic and cytotoxic effects of clofarabine on T47D cell line were in time and dose dependent manner; therefore it could be considered a new candidate in breast cancer therapy. |
### Instruction:
Are oncogenic PI3K mutations as common as AKT1 and SMO mutations in meningioma?
### Response:
| This work identifies PI3K signaling as an important target for precision medicine trials in meningioma patients. |
### Instruction:
Is increased CSF neurogranin concentration specific to Alzheimer disease?
### Response:
| These results confirm an increase in CSF Ng concentration in patients with AD as previously reported and show that this is specific to AD and not seen in a range of other neurodegenerative diseases. |
### Instruction:
Does intracavernosal Prostaglandin Injection Prior to Circumcision allow More Precise Removal of Foreskin?
### Response:
| Circumcisions performed with ICI is a novel technique that allows accurate removal of foreskin and can be safely applied to current surgical technique for improved cosmetic results. |
### Instruction:
Do beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells?
### Response:
| In summary, our study confirmed the positive regulation by HMGB1 and Beclin1 on the α-synuclein degradation and on the starvation-induced autophagy in PC12 cells, implying both markers as prominent targets to promote the α-synuclein degradation. |
### Instruction:
Does hSP60 play a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis?
### Response:
| IL-1β induces expression of HSP60 in N9 microglial cells that further augments inflammation via TLR4-p38 MAPK axis. |
### Instruction:
Are young male sex workers at high risk for sexually transmitted infections , a cross-sectional study from Dutch STI clinics , the Netherlands , 2006-2012?
### Response:
| Health promotion activities should target MSW who are young, homo- or bisexual, those who are HIV-infected or who have never been tested for HIV, to increase early diagnosis, prevention and treatment. |
### Instruction:
Does self-reported Health Care Utilization of Patients with Inflammatory Bowel Disease correlate Perfectly with Medical Records?
### Response:
| We report a high concordance between costs of self-reported health care utilization and administrative data over the past year in IBD. Self-reported health care utilization reliably measures the consumption of health care in IBD. |
### Instruction:
Is high-dose flecainide the most effective treatment of fetal supraventricular tachycardia?
### Response:
| Flecainide is highly effective in achieving SR in hydropic and nonhydropic fetuses with supraventricular tachycardia in a median time of 3 days. In our opinion, flecainide should be considered as first-line therapy in fetal supraventricular tachycardia with and without hydrops. |
### Instruction:
Does low vascularity predict favourable outcomes in leiomyoma patients treated with uterine artery embolization?
### Response:
| Low vascularity and solitary leiomyoma indicated favourable outcomes in patients treated with UAE. |
### Instruction:
Does ultrasound associated with caffeine increase basal and beta-adrenoceptor response in adipocytes isolated from subcutaneous adipose tissue in pigs?
### Response:
| The results demonstrate that increased lipolysis of caffeine + US is due to an increase in basal and beta-adrenoceptor response by caffeine, and caffeine's effect is local, avoiding unwanted effects. |
### Instruction:
Does ketamine exposure during embryogenesis inhibit cellular proliferation in rat fetal cortical neurogenic regions?
### Response:
| These data suggest that exposure to ketamine during embryogenesis can dose-dependently inhibit the cellular proliferation in neurogenic regions of the rat fetal cortex. |
### Instruction:
Is podocyturia significantly elevated in untreated vs treated Fabry adult patients?
### Response:
| Patients with Fabry disease display heavy podocyturia; those untreated present significantly higher podocyturia, lower proteinuria and better renal function than those who are treated, suggesting that therapy may be started at advanced stages. Podocyturia may antedate proteinuria, and enzyme therapy may protect against podocyte loss. |
### Instruction:
Does knockdown of USP39 by lentivirus-mediated RNA interference suppress the growth of oral squamous cell carcinoma?
### Response:
| In conclusion, the inhibition of USP39 in CAL27 cells suppressed cell growth probably via induction cell cycle arrest and apoptosis. USP39 might act as an oncogenic factor in OSCC and could be a potential molecular target for OSCC gene therapy. |
### Instruction:
Is sedentary lifestyle in middle-aged women associated with severe menopausal symptoms and obesity?
### Response:
| There was a high prevalence of sedentary lifestyle in this middle-aged Latin American female sample which was associated with more severe menopausal symptoms and obesity. |
### Instruction:
Does down-regulation of microRNA-184 contribute to the development of cyanotic congenital heart diseases?
### Response:
| Our findings indicate that inhibition of microRNA-184 may contribute to the development of cyanotic CHD via decreasing proliferation and inducing apoptosis of cardiomyocytes. Moreover, miR-184 inhibition may promote hypoxia-induced apoptosis via activation of caspase-3 and caspase-9. Congenital down-regulation of miR-184 may be a mechanism leading to CHD development. |
### Instruction:
Is the macrophage activation product sCD163 associated with a less favourable metabolic profile in prepubertal children?
### Response:
| Childhood obesity may increase the risk of developing metabolic diseases later in life through chronic macrophage activation having deleterious effects on metabolism. |
### Instruction:
Does cD133 Expression at the Metastatic Site predict Patients ' Outcome in Colorectal Cancer with Synchronous Liver Metastasis?
### Response:
| Patients without CD133 expression in liver metastasis had significantly shorter survival, perhaps because mCD133- patients had a significantly higher rate of extrahepatic recurrence. |
### Instruction:
Is overexpression of Transmembrane Protein BST2 Associated with Poor Survival of Patients with Esophageal , Gastric , or Colorectal Cancer?
### Response:
| The results suggest that BST-2 is involved in tumor progression and serves as an independent prognostic classifier for patients with GC. Because BST-2 is expressed on the cell membrane, BST-2 could be a therapeutic target for GC, CRC, and ESCC. |
### Instruction:
Does kLF4 suppress Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis?
### Response:
| The study demonstrates that KLF4 plays a significant role in the pathogenesis of colorectal neoplasia. |
### Instruction:
Does dissociation mediate the association between intimate partner violence and posttraumatic stress among treatment-seeking incarcerated women?
### Response:
| This finding highlights the need for additional research concerning dissociation among women in prison and warrants consideration in future research and intervention efforts focused on trauma recovery among incarcerated women. |
### Instruction:
Does [ Lactate levels with regard to the pulse pressure in patients with shock ]?
### Response:
| Even when several studies emphasize the clinical significance of biomarkers in the diagnosis and management of patients with hypovolemic shock, it is necessary to do more studies in order to find the efficacy of the non-invasive screening in this type of pathology. |
### Instruction:
Does loss of REM sleep feature across nighttime in REM sleep behavior disorder?
### Response:
| Patients with PD or iRBD lost the physiologic nocturnal increase in REM sleep duration, and patients with RBD (either with or without PD) lost the increase of REMs frequency across the night, suggesting an alteration in the circadian system in RBD. This supports the hypothesis of a direct effect of melatonin on RBD symptoms by its chronobiotic activity. |
### Instruction:
Does homeopathic Rhus toxicodendron have dual effects on the inflammatory response in the mouse preosteoblastic cell line MC3T3-e1?
### Response:
| Homeopathic dilution of Rhus tox has a dual activity that increases COX-2 expression and decreases NO generation, thus modulating inflammation. Further study is needed to examine the cellular signaling mechanisms that are associated with inflammatory regulation by Rhus tox treatment in greater detail. |
### Instruction:
Does [ A novel homozygous mutation in PLA2G6 gene cause infantile neuroaxonal dystrophy in a case ]?
### Response:
| The psychomotor regression and tetraparesis of the patient was caused by infantile neuroaxonal dystrophy due to a novel homozygous mutation in the PLA2G6 gene, which was inherited from her parents. |
### Instruction:
Is upright activity within the first week after stroke associated with better functional outcome and health-related quality of life : A Norwegian multi-site study?
### Response:
| This study confirms the beneficial effect of upright activity applied during hospital stay in Norwegian stroke units. |
### Instruction:
Does diffusion-weighted Imaging ( DWI ) predict Upgrading of Gleason Score in Biopsy-proven Low-grade Prostate Cancers?
### Response:
| DWI may predict GS upgrading of biopsy-proven low-grade prostate cancers. The use of cancer ADC |
### Instruction:
Does artificial shrinkage of blastocoel using a laser pulse prior to vitrification improve clinical outcome?
### Response:
| This study demonstrated that the removal of blastocoel fluid before vitrification by laser pulse of in vitro-produced human blastocysts significantly improves blastocyst survival, clinical pregnancy, and implantation rates. |
### Instruction:
Are obesity-driven alterations in adipose-derived stem cells partially restored by weight loss?
### Response:
| This study demonstrates that an initial obese environment triggers a detrimental state in ASCs that is not completely recovered after weight loss. |
### Instruction:
Is the H3F3 K36M mutant antibody a sensitive and specific marker for the diagnosis of chondroblastoma?
### Response:
| Our data demonstrate the specificity and sensitivity of this immunomarker, and will be a useful adjunct for reaching a diagnosis of chondroblastoma. |
### Instruction:
Is recombinant human thyrotropin-stimulated thyroglobulin level at the time of radioactive iodine ablation an independent prognostic marker of differentiated thyroid carcinoma in the setting of prophylactic central neck dissection?
### Response:
| A low stimulated serum Tg level at rhTSH-aided RAI ablation may be a favourable prognostic marker in the setting of prophylactic CND. |
### Instruction:
Does the pre-operative rate of growth of colorectal metastases in patients selected for liver resection influence post-operative disease-free survival?
### Response:
| The rate of growth of colorectal liver metastases prior to surgery should not be used as a prognostic factor when considering the role of resection. |
### Instruction:
Do cardiovascular malformations caused by NOTCH1 mutations keep left : data on 428 probands with left-sided CHD and their families?
### Response:
| Pathogenic mutations in NOTCH1 were identified in 7% of familial LS-CHD and in 1% of sporadic LS-CHD. The penetrance is high; a cardiovascular malformation was found in 75% of NOTCH1 mutation carriers. The phenotypic spectrum includes LS-CHD, RS-CHD, CTD, and TAA. Testing NOTCH1 for an early diagnosis in LS-CHD/RS-CHD/CTD/TAA is warranted.Genet Med 18 9, 914-923. |
### Instruction:
Is alkaline phosphatase normalization a biomarker of improved survival in primary sclerosing cholangitis?
### Response:
| Alkaline phosphatase normalization, particularly if persistent, represents a robust biomarker of improved long-term survival and decreased risk of requiring liver transplantation in patients with primary sclerosing cholangitis. |
### Instruction:
Are novel alleles of the VERNALIZATION1 genes in wheat associated with modulation of DNA curvature and flexibility in the promoter region?
### Response:
| New allelic variants of the VRN-A1 and VRN-B1 genes were identified in hexaploid and tetraploid wheat. Mutations in A-tract and C-rich segments within the VRN-box of VRN-A1 are associated with modulation of the vernalization requirement and flowering time. New allelic variants will be useful in fundamental investigations into the regulation of VRN1 expression, and provide a valuable genetic resource for practical breeding of wheat. |
### Instruction:
Do development of a metabolites risk score for one-year mortality risk prediction in pancreatic adenocarcinoma patients?
### Response:
| The mass spectrometry-based metabolomic profiling of serum represents a valid tool for discovering novel candidate biomarkers with prognostic ability to predict one-year mortality risk in patients with pancreatic adenocarcinoma. |
### Instruction:
Does clinical DRUJ instability influence the long-term functional outcome of conservatively treated distal radius fractures?
### Response:
| The presence of clinical DRUJ instability does not seem to affect functional outcome of conservatively treated distal radius fractures at long-term follow-up. |
### Instruction:
Does novel cerebrotendinous xanthomatosis mutation cause familial early dementia in Colombia?
### Response:
| The mutation found in this family is responsible for the described dementia features. Early identification of familial history with mental retardation, xanthomas and cognitive impairment might prevent the progression to this treatable type of dementia. Even though this mutation lies in the most frequently mutated codon of CYP27A1 gene, it has not been reported previously. |
### Instruction:
Do casamino acids facilitate the secretion of recombinant dengue virus serotype-3 envelope domain III in Pichia pastoris?
### Response:
| The strategy described herein could enable fulfilling the mounting demand for recombinant EDIII as well as lay direction to future studies on secretory expression of recombinant proteins in P. pastoris with CA as a media supplement. |
### Instruction:
Is glucose-6-Phosphate Dehydrogenase Deficiency in Brazilian Children With Sickle Cell Anemia Associated With Clinical Ischemic Stroke or High-Risk Transcranial Doppler?
### Response:
| Our study demonstrated that G6PD molecular deficiency was not associated either with clinical ischemic stroke or high-risk TCD. Similarly, we found no associations between G6PD enzyme activity and stroke or high-risk TCD. Small sample size precludes definitive conclusions. |
### Instruction:
Does impact of grassland management regimes on bacterial endophyte diversity differ with grass species?
### Response:
| Endophytic bacteria play an important role in plant health and growth. However, studies addressing the influence of grassland management regimes on these bacteria in above-ground plant parts are still missing. In this study, we present first evidence that fertilizer application significantly impacted bacterial community structures in three agricultural important grass species, whereas mowing had only a minor effect. Moreover, this effect was plant-specific and thus not visible for all grass species in each year. Consequently, this study sheds new light into the complex interaction of microbes and plants. |
### Instruction:
Is high mobility group box 1 increased in the sera of psoriatic patients with disease progression?
### Response:
| Our data provide insights into a possible role of HMGB1 for inflammation in PV. |
### Instruction:
Does mTORC1 alter the expression of glycolytic genes by regulating KPNA2 abundances?
### Response:
| Identifying mTORC1-regulated proteins through proteomic method is a feasible way to study the downstream functions of mTORC1. In this study, we identified many mTORC1-regulated proteins using proteomic analysis by overlapping two different high vs low/no mTORC1 activity comparisons, TSC2(-/-) vs WT MEFs and TSC2(-/-) with/without rapamycin treatment. We found the abundances of many enzymes in glycolysis pathway and several proteins involved in protein nuclear import were positively regulated by mTORC1. More importantly, we first discovered that mTORC1 positively regulated the importer protein KPNA2, which participated in glycolysis regulation downstream of mTORC1 in a HIF1α-independent manner, indicating that mTORC1 regulates glycolysis through multiple ways. |
### Instruction:
Does overexpression of Vitreoscilla hemoglobin increase waterlogging tolerance in Arabidopsis and maize?
### Response:
| These results demonstrate that the exogenous VHb gene confers waterlogging tolerance to the transgenic maize line. In Maize in the place of to the transgenic maize line, the VHb gene is a useful molecular tool for the improvement of waterlogging and submergence-tolerance. |
### Instruction:
Does diabetic gastroparesis alter the biomagnetic signature of the gastric slow wave?
### Response:
| Gastric slow wave parameters obtained from MGG recordings distinguish gastroparesis patients from controls. Assessment of slow wave propagation may prove critical to characterization of underlying disease processes. Future studies should determine pathologic indicators from MGG associated with other functional gastric disorders, and whether multichannel EGG with appropriate signal processing also reveals pathology. |
### Instruction:
Is donor TSH level associated with clinical pregnancy among oocyte donation cycles?
### Response:
| Donor TSH level, independent of recipient TSH level, is associated with recipient clinical pregnancy. These findings suggest that thyroid function may impact the likelihood of pregnancy at the level of the oocyte. |
### Instruction:
Does maternal Serum Zinc Concentration during Pregnancy be Inversely Associated with Risk of Preterm Birth in a Chinese Population?
### Response:
| Maternal serum zinc concentration during pregnancy is inversely associated with risk of preterm birth in the Chinese population, and the results are driven by maternal SZC in the first trimester. |
### Instruction:
Is a high thyroid stimulating hormone level associated with diabetic peripheral neuropathy in type 2 diabetes patients?
### Response:
| TSH level is independently associated with DPN in Chinese population with T2DM. A high serum TSH level may be a potential risk factor for DPN. |
### Instruction:
Do in-hospital free fatty acids levels predict the severity of myocardial ischemia of acute coronary syndrome?
### Response:
| Higher in-hospital levels of FFAs persist and may reflect the severity of ischemia and necrosis during the subacute phase of ACS attack. |
### Instruction:
Is lactate Clearance in Septic Shock a Surrogate for Improved Microcirculatory Flow?
### Response:
| We observed no association between degree of LC and change in microcirculatory blood flow in patients with septic shock. These data suggest against the hypothesis that LC may be used as a surrogate marker of microcirculatory blood flow. |
### Instruction:
Does one year of training with FES have impressive beneficial effects in a 36-year-old woman with spinal cord injury?
### Response:
| These impressive improvements demonstrate that FES training offers several interesting clinical benefits in a patient with SCI. |
### Instruction:
Does recombinant Factor IX Fc Fusion Protein maintain Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice?
### Response:
| The activation by factor XIa or factor VIIa/tissue factor, inhibition by AT, interaction profiles with phospholipids, affinities for factor VIIIa within the context of the Xase complex, and thrombin generation profiles were similar for rFIXFc and rFIX. Xase complexes formed with either molecule exhibited similar kinetic profiles for factor Xa generation. In acute efficacy models, mice infused with rFIXFc or rFIX were equally protected from bleeding. However, in prophylactic efficacy models, protection from bleeding was maintained approximately three times longer in rFIXFc-dosed mice than in those given rFIX; this prolonged efficacy correlates with the previously observed half-life extension. We conclude that rFIXFc retains critical FIX procoagulant attributes and that the extension in rFIXFc half-life translates into prolonged efficacy in hemophilia B mice. |
### Instruction:
Does preoperative Aspects and Dimensions Used for Anatomical Score predict Treatment Failures in Laparoscopic Cryoablation of Small Renal Masses?
### Response:
| The PADUA score significantly predicts residual unablated tumor and DFS following LCA. Further studies are needed to validate the efficacy of the PADUA score in relation to oncologic outcomes following ablative procedures. |
### Instruction:
Does the Expression of MicroRNA-155 in Plasma and Tissue be Matched in Human Laryngeal Squamous Cell Carcinoma?
### Response:
| The expression of tissue and plasma miR-155 were significantly up-regulated in patients with LSCC. Our work will serve as a basis for further investigation, preferably large-scale validation in clinical trials. |
### Instruction:
Does phenethyl isothiocyanate ( PEITC ) suppress prostate cancer cell invasion epigenetically through regulating microRNA-194?
### Response:
| Our results indicate that miR-194 downregulates the expression of oncogenic MMP2 and MMP9 by targeting BMP1, which suggests a potential new mechanistic target by which PEITC suppresses prostate cancer cell invasiveness. |
### Instruction:
Is elevated urinary Na/K ratio among Lebanese elementary school children attributable to low K intake?
### Response:
| About 50 % of children exceeded the recommended daily upper intake for Na, while the majority was below K adequate intake. This unfavorable Na/K ratio is indicative of potentially negative health effects at later stages in life. Interventions aimed at reducing salt intake and increasing consumption of fruits and vegetables are warranted. |
### Instruction:
Does obesity inhibit the osteogenic differentiation of human adipose-derived stem cells?
### Response:
| Collectively, these results indicate that obesity reduces the osteogenic differentiation capacity of ASCs such that they may have a limited suitability as a cell source for tissue engineering. |
### Instruction:
Does traditional scores versus IRT estimate on forced-choice tests based on a dominance model?
### Response:
| A dominance model produces a linear relationship between TS and true scores, and the subjects with extreme thetas are better measured. |
### Instruction:
Is health literacy independently associated with self-care behavior in patients with heart failure?
### Response:
| Critical HL was independently associated with self-care behavior in HF patients. |
### Instruction:
Does postoperative CA19-9 Change be a Useful Predictor of Intrahepatic Cholangiocarcinoma Survival following Liver Resection?
### Response:
| Patients who have normalized CA19-9 levels postoperatively have longer survival outcomes. Therefore, normalized postoperative CA19-9 may be a useful clinical marker for ICC survival. |
### Instruction:
Does routine whole body CT of high energy trauma patients lead to excessive radiation exposure?
### Response:
| The risk of developing radiation induced cancer is significant for young people if exposed to relatively high dose radiation as is the case in WBCT. WBCT in high-energy trauma is important for planning of treatment in severely injured patients while it can be questioned in the seemingly not injured where it is used mainly to permit early discharge from the ED. |
### Instruction:
Does distribution and characteristics of slow-cycling cells in rat vocal fold?
### Response:
| Most slow-cycling cells resided in the epithelium, exhibiting various phenotypes in a relatively undifferentiated condition, and they are suspected to contribute to the tissue repair of the injured VFs. |
### Instruction:
Does reduction of proteinuria by therapeutic intervention improve the renal outcome of elderly patients with IgA nephropathy?
### Response:
| In elderly IgAN patients, the reduction of proteinuria by therapeutic interventions may lead to better renal outcomes without causing severe extrarenal complications. |
### Instruction:
Does nADPH Oxidase-4 Overexpression be Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma?
### Response:
| Ciliary dysfunction is increased in neutrophilic asthma associated with increased NOX4 expression and is attenuated by NADPH oxidase inhibition. |
### Instruction:
Is progression of cartilage degeneration and clinical symptoms in obese and overweight individuals dependent on the amount of weight loss : 48-month data from the Osteoarthritis Initiative?
### Response:
| WL over 48 months is associated with slowed knee cartilage degeneration and improved knee symptoms. |
### Instruction:
Does amphetamine manipulate monoamine oxidase-A level and behavior using theranostic aptamers of transcription factors AP-1/NF-kB?
### Response:
| Our data lead us to conclude that elevation of AP-1 or NF-kB indirectly decreases MAO-A protein levels which, in turn, diminishes MAO-A ability in the VTA of the mesolimbic dopaminergic pathway that has been implicated in cells under stress especially in the SN and VTA. This study has implications for design for the treatment of drug exposure and perhaps Parkinson's dementia. |
### Instruction:
Is obesity-induced p53 activation in insulin-dependent and independent tissues inhibited by beta-adrenergic agonist in diet-induced obese rats?
### Response:
| Results of the present study obviously showed that beta-adrenergic receptor agonist/cAMP prevented obesity-induced p53 activation. Although this effect in metabolic insulin target tissues tempted us to consider them as insulin sensitizers in obesity-related diabetes, p53 inhibition in non-insulin target tissues warned about the impairment of anti-cancer mechanisms in obese subjects. |
### Instruction:
Do [ Study of in vitro expression of human platelet ITGB3 gene nonsense mutation c.1476G > A ]?
### Response:
| The ITGB3 c.1476G>A mutation can decrease the transcription level and further affect GPIIIa synthesis and CD61 antigen expression. |
### Instruction:
Does walking-Induced Fatigue lead to Increased Falls Risk in Older Adults?
### Response:
| As most falls occur when an individual is moving and/or fatigued, assessing functional properties related to balance, gait, strength, and falls risk in older adults both at rest and following activity may provide additional insight. |
### Instruction:
Does pre-morbid glycemic control modify the interaction between acute hypoglycemia and mortality?
### Response:
| In critically ill patients, chronic pre-morbid hyperglycemia increases the risk of hypoglycemia and modifies the association between acute hypoglycemia and mortality. |
### Instruction:
Do neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype?
### Response:
| Neutrophils are crucially involved in cardiac repair after MI by polarizing macrophages towards a reparative phenotype. Therapeutic strategies to reduce acute neutrophil-driven inflammation after MI should be carefully balanced as they might interfere with the healing response and cardiac remodelling. |
### Instruction:
Does rGS10 deficiency ameliorate the severity of disease in experimental autoimmune encephalomyelitis?
### Response:
| These data demonstrate a critical role for RGS10 in mediating autoimmune disease through regulation of T lymphocyte function. This is the first study ever conducted to elucidate the function of RGS10 in effector lymphocytes in the context of EAE. The identification of RGS10 as an important regulator of inflammation might open possibilities for the development of more specific therapies for MS. |
### Instruction:
Does tumor Infiltrative Pattern predict Sites of Recurrence After Curative Gastrectomy for Stages 2 and 3 Gastric Cancer?
### Response:
| Evaluation of the INF type shows promise for its role as a predictor of postoperative recurrence sites in patients with GC. |
### Instruction:
Does the histone demethylase dKDM5/LID interact with the SIN3 histone deacetylase complex and shares functional similarities with SIN3?
### Response:
| We have provided genetic evidence to demonstrate functional cooperation between the histone demethylase dKDM5/LID and SIN3. Biochemical and transcriptome data further support functional links between these proteins. Together, the data provide a solid framework for analyzing the gene regulatory pathways through which SIN3 and dKDM5/LID control diverse biological processes in the organism. |
### Instruction:
Are classical scrapie prions associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep?
### Response:
| These findings show that scrapie prions are associated with monocytes and T lymphocytes circulating in the peripheral blood of sheep naturally infected with classical scrapie. Combined with our previous findings, we can now conclude that all three major subsets of PBMC can harbor prions during preclinical disease and thus, present logical targets for development of a sensitive assay to detect scrapie prions. In this regard, we have also demonstrated that sPMCA can be used to detect scrapie prions associated with PBMC. |
### Instruction:
Is qT interval , corrected for heart rate , associated with HbA1c concentration and autonomic function in diabetes?
### Response:
| Although there are concerns about hypoglycaemia in general in people with Type 1 diabetes, chronic hyperglycaemia, rather than intermittent hypoglycaemia, appears to be more deleterious to autonomic cardiac function, even in adolescence. Longer QTc was associated with higher HbA1c concentration, lower risk of hypoglycaemia and autonomic dysfunction. Longitudinal studies are warranted. |
### Instruction:
Does complement component C3a play a critical role in endothelial activation and leukocyte recruitment into the brain?
### Response:
| Our study provides the first evidence that C3a plays a critical role in cerebral endothelial activation and leukocyte recruitment during inflammation in the brain. |
### Instruction:
Do ferula gummosa Boiss flower and leaf extracts inhibit angiogenesis in vitro?
### Response:
| Our findings revealed that F. gummosa Boiss flower and leaf extracts may contain antiangiogenic compounds, which could be used in preparation of new therapeutic agents for inhibition of tumor angiogenesis. To the best of our knowledge, this is the first report of antiangiogenic effects of F. gummosa Boiss flower and leaf extracts and more studies are needed to identify the effective components of the extracts. |
### Instruction:
Does home nursing care with the self-care model improve self-efficacy of patients with chronic obstructive pulmonary disease?
### Response:
| According to the study results, home nursing care based on the Orem's self-care model is effective in improving self-efficacy of patients with chronic obstructive pulmonary disease. |
### Instruction:
Do human Adipose-Derived Mesenchymal Stromal/Stem Cells Remain Viable and Metabolically Active Following Needle Passage?
### Response:
| Human, culture-expanded AMSCs maintain their viability, proliferative capacity, and metabolic function following passage through needles as small as 30-gauge at constant flow rates of 4 mL/min, despite an early, nonspecific stress/cytoprotective response. These initial findings suggest that culture-expanded AMSCs should tolerate the injection process during most cell-based therapeutic interventions. |
### Instruction:
Does a Genetic Risk Score be Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery?
### Response:
| We identified two GRSs composed of BMI and WHR-associated SNPs with significant impact on weight loss after RYGB surgery using random forest analysis as a SNP selection tool. The GRS may be useful to pre-surgically evaluate the risks for patients undergoing RYGB surgery. |
### Instruction:
Is the protective or damaging effect of Tumor necrosis factor-α in acute liver injury concentration-dependent?
### Response:
| Our results suggested that TNF-α had a dual role in acute liver injury. It was regulated might via the corporate effect of NF-κB signal pawahway and anti-apoptosis. Meanwhile, our findings provide a reference for clinical treatment of acute liver injury. |
### Instruction:
Does microRNA-181b improve Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue?
### Response:
| Our data underscore the importance of adipose tissue EC function in controlling the development of insulin resistance. Delivery of miR-181b or Pleckstrin homology domain leucine-rich repeat protein phosphatase inhibitors may represent a new therapeutic approach to ameliorate insulin resistance by improving adipose tissue endothelial Akt-endothelial nitric oxide synthase-nitric oxide signaling. |
### Instruction:
Does myeloid interferon-γ receptor deficiency affect atherosclerosis in LDLR ( -/- ) mice?
### Response:
| Overall, our data argue against a role for myeloid IFNγR2 in atherosclerosis development. Since myeloid IFNγ signaling seems to be nonessential throughout atherogenesis, it is important to understand the mechanisms by which IFNγ acts in atherogenesis. In the future new studies should be performed considering other cell-specific targets. |
### Instruction:
Does a Missense LRRK2 Variant be a Risk Factor for Excessive Inflammatory Responses in Leprosy?
### Response:
| The results support a preferential association of LRRK2 variants with T1R. LRRK2 involvement in T1R is likely due to a pathological pro-inflammatory loop modulated by LRRK2 availability. Interestingly, the M2397T variant was reported in association with Crohn's disease with the same risk allele as in T1R suggesting common inflammatory mechanism in these two distinct diseases. |
### Instruction:
Does deletion of the hemopexin or heme oxygenase-2 gene aggravate brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage?
### Response:
| This study suggests that microglial cells contribute to hemoglobin-heme clearance after ICH; however, the resultant iron overloads in microglia appear to decrease Iba1 expression and to further inhibit microglial phagocytosis. |
### Instruction:
Does thymol accelerate the recovery of the skeletal muscle of mice injured with cardiotoxin?
### Response:
| This study suggests that thymol ameliorates inflammatory response and accelerates regeneration in cardiotoxin-induced muscle injury. |
### Instruction:
Does iatrogenic Subclinical Hyperthyroidism Promote Weight Loss?
### Response:
| Among total thyroidectomy patients, weight change did not differ between SCH patients and euthyroid patients at years 1 through 3. As such, the use of levothyroxine to induce SCH did not lead to long-term weight change when compared with euthyroid patients. |
### Instruction:
Is expression of MECOM associated with unfavorable prognosis in glioblastoma multiforme?
### Response:
| MECOM could be considered as an independent prognostic factor in GBM, predicting it as a potential and promising molecular drug target. |
### Instruction:
Does high dietary cholesterol intake during lactation promote development of fatty liver in offspring of mice?
### Response:
| These findings demonstrate that excessive maternal cholesterol intake during lactation enhances the susceptibility of the offspring to development of fatty liver. |
### Instruction:
Is elevated Serum Concentration of Chitinase 3-Like 1 an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients?
### Response:
| Our results suggest that elevated serum CHI3L1 concentration is an independent prognostic biomarker for poorer survival in lung cancer patients. |
### Instruction:
Does dabigatran but not rivaroxaban or apixaban treatment decrease fibrinolytic resistance in patients with atrial fibrillation?
### Response:
| Our data suggest that dabigatran, contrary to rivaroxaban and apixaban, reduces fibrinolytic resistance by virtue of its greater impact on TAFI activation. The profibrinolytic effect of dabigatran may play a role locally, at sites of fibrin formation, by making the nascent thrombus more susceptible to plasminogen-dependent degradation. |
### Instruction:
Do early thromboembolic events ≤1week after fast-track total hip and knee arthroplasty?
### Response:
| Incidence of "early" TEEs after fast-track THA and THA is low, but MIs may be further reduced by improving perioperative treatment of anemia. Further research is needed regarding interventions for prevention of "early" TEE in disposed patients. |
### Instruction:
Does a Polymorphism in the FGFR4 Gene be Associated With Risk of Neuroblastoma and Altered Receptor Degradation?
### Response:
| The FGFR4 Arg388 polymorphism is associated with an increased prevalence of neuroblastoma in children, and this association may be linked to differences in FGFR4 degradation rates. Our study provides the first evidence of a role for FGFR4 in neuroblastoma, suggesting that FGFR4 genotype and the pathways regulating FGFR4 trafficking and degradation may be relevant for neuroblastoma pathogenesis. |
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