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### Instruction:
Does magnetic Resonance Therapy improve Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder?
### Response:
| These open-label data show trends toward normalization of EEG and concomitant clinical improvement using magnetic stimulation for PTSD. |
### Instruction:
Does bee venom acupuncture alleviate trimellitic anhydride-induced atopic dermatitis-like skin lesions in mice?
### Response:
| These results indicate that BV injection at specific acupuncture points effectively alleviates AD-like skin lesions by inhibiting inflammatory and allergic responses in a TMA-induced contact hypersensitivity mouse model. |
### Instruction:
Does skeletal Tumor Burden on Baseline 18F-Fluoride PET/CT predict Bone Marrow Failure After 223Ra Therapy?
### Response:
| 223Ra was beneficial and reduced the risk of death even in patients with a high skeletal tumor burden. Fluoride PET/CT is able to determine which patients will benefit from 223Ra and which will develop BMF. |
### Instruction:
Is low resting heart rate associated with violence in late adolescence : a prospective birth cohort study in Brazil?
### Response:
| Low resting heart rate predicted violent and non-violent crime for males, and was cross-sectionally associated with crime for females. Biological factors may contribute to individual propensity to commit crime, even in a middle-income setting with high rates of violence. |
### Instruction:
Is the consumption of two or more fall risk-increasing drugs rather than polypharmacy associated with falls?
### Response:
| Among high risk fallers, the use of two or more FRID was an independent risk factor for falls instead of polypharmacy. Our findings will inform clinical practice in terms of medication reviews among older adults at higher risk of falls. Future intervention studies will seek to confirm whether avoidance or withdrawal of multiple FRID reduces the risk of future falls. Geriatr Gerontol Int 2016; ●●: ●●-●●. |
### Instruction:
Does pttg1 promote Growth of Breast Cancer through P27 Nuclear Exclusion?
### Response:
| Pttg1 may increase BC cell growth through nuclear exclusion of p27, which highlights a novel molecular regulatory machinery in tumorigenesis of BC. |
### Instruction:
Does nucleosome Assembly Protein 1-Like 1 ( Nap1l1 ) regulate the Proliferation of Murine Induced Pluripotent Stem Cells?
### Response:
| The results indicate that Nap1l1 promotes the proliferation of iPSC attributable to G2/M transition caused by downregulation of p27 and p21, and upregulation of cyclin B1, the activation of AKT or ERK is involved in the process. The present study has revealed a novel molecular mechanism involved in the proliferation of iPSC. |
### Instruction:
Does tIPE2 alleviate Systemic Lupus Erythematosus Through Regulating Macrophage Polarization?
### Response:
| TIPE2 alleviates experimental SLE through induction of macrophage polarization to a M2 phenotype, which may be used as a promising therapeutic strategy for treating SLE. |
### Instruction:
Does placental Growth Factor promote Ovarian Cancer Cell Invasion via ZEB2?
### Response:
| PLGF enhances OVC cell invasion through MAPK-p38-dependent activation of ZEB2. |
### Instruction:
Is vitamin D deficiency associated with high prevalence of diabetes in Kuwaiti adults : results from a national survey?
### Response:
| Data from Kuwaiti's first nutrition nutritional survey suggests a very high prevalence of vitamin D deficiency in Kuwaiti adults. Associations of low vitamin D status and high prevalence of diabetes point to the need of continuous monitoring of vitamin D status and further evaluating potential health consequences in this high-risk population. |
### Instruction:
Do effect of transcranial direct current stimulation on pain anxiety during burn wound care?
### Response:
| According to our study, cathodal cortical stimulation with tDCS is associated with significant reduction in pain anxiety in burn patients. |
### Instruction:
Are genetic variants of ADAM17 implicated in the pathological process of Kawasaki disease and secondary coronary artery lesions via the TGF-β/SMAD3 signaling pathway?
### Response:
| Our results suggest that ADAM17 contributes to the KD risk and is involved in secondary CAL formation via the TGF-β/SMAD3 signaling pathway. This further enriches our understanding of the importance of the signaling pathway in KD occurrence and outcomes. |
### Instruction:
Is respiratory function associated to marathon race time?
### Response:
| These results suggest a significant relationship between individual pulmonary function and marathon race time. Thus, a higher lung capacity per kg of body mass might be a key variable for marathon performance in amateur runners. |
### Instruction:
Does methylation profiling of choroid plexus tumors reveal 3 clinically distinct subgroups?
### Response:
| Methylation profiling of choroid plexus tumors reveals 3 distinct subgroups (ie, pediatric low-risk choroid plexus tumors [cluster 1], adult low-risk choroid plexus tumors [cluster 2], and pediatric high-risk choroid plexus tumors [cluster 3]) and may provide useful prognostic information in addition to histopathology. |
### Instruction:
Does treprostinil Iontophoresis improve Digital Blood Flow during Local Cooling in Systemic Sclerosis?
### Response:
| In patients with SSc, digital treprostinil iontophoresis shifts skin blood flow upward during local cooling of the hand and during the initial rewarming phase. Digital treprostinil iontophoresis should now be tested in larger scale studies. |
### Instruction:
Does estrogen receptor β regulate endometriotic cell survival through serum and glucocorticoid-regulated kinase activation?
### Response:
| ERβ leads to SGK1 overexpression in endometriosis, which contributes to the survival of endometriotic lesions through inhibition of apoptosis. |
### Instruction:
Does the Succinate Receptor GPR91 be Involved in Pressure Overload-Induced Ventricular Hypertrophy?
### Response:
| Our findings indicate that succinate-GPR91 signaling may be involved in RVH via PI3K/Akt signaling in vivo and in vitro. Therefore, GPR91 may be a novel therapeutic target for treating pressure overload-induced RVH. |
### Instruction:
Does platelet CD40 exacerbate Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes?
### Response:
| Platelet CD40 plays a crucial role in inflammation by stimulating leukocyte activation and recruitment and activation of endothelial cells, thereby promoting atherosclerosis. |
### Instruction:
Does interleukin-17A induce IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome?
### Response:
| Our results suggest that IL-17A triggers a key inflammatory mediator, IL-1β, from RPE cells, via NLRP3 inflammasome activation, holding therapeutic potential for AMD. |
### Instruction:
Does miR-211 inhibit cell proliferation and invasion of gastric cancer by down-regulating SOX4?
### Response:
| miR-211 could inhibit GC cell proliferation and invasion partially by down-regulating SOX4. MiR-211 might be a potential therapeutic target for GC treatment in the future. |
### Instruction:
Is increased expression of senescence markers p14 ( ARF ) and p16 ( INK4a ) in breast cancer associated with an increased risk of disease recurrence and poor survival outcome?
### Response:
| These finding suggest p16(INK4a) expression and p14(ARF) expression may play an important role in the progression of proliferative breast tissue to invasive cancer, and may be useful as prognostic factors. |
### Instruction:
Is malignancy a risk factor for postoperative infectious complications after elective colorectal resection?
### Response:
| Malignancy, age, tobacco history, and obesity increase the risk of ICs after colorectal resection. Improvement of the modifiable risk factors, increased compliance with an enhanced recovery after surgery (ERAS) program in the overall population, and optimization of immune function in patients with malignancy should be considered. |
### Instruction:
Does structural brain correlate of cognitive and behavioral impairment in MND?
### Response:
| Cortical thinning and WM degeneration are highly associated with neuropsychological and behavioral symptoms in patients with MND. DT MRI metrics seem to be the most sensitive markers of extra-motor deficits within the MND spectrum. |
### Instruction:
Do a case of butane hash oil ( marijuana wax ) -induced psychosis?
### Response:
| This study highlights the need for future research regarding the potential medical and psychiatric effects of new, high-potency forms of marijuana. Could cannabis have a dose-dependent impact on psychosis? What other potential psychiatric effects could emerge heretofore unseen in lower potency formulations? Given the recent legalization of marijuana, these questions merit timely exploration. |
### Instruction:
Does eph-B4 mediate vein graft adaptation by regulation of endothelial nitric oxide synthase?
### Response:
| eNOS is a mediator of vein graft adaptation to the arterial environment. Eph-B4 stimulates eNOS phosphorylation in vitro and may mediate vein graft adaptation by regulation of eNOS activity in vivo. |
### Instruction:
Does [ MiR-519 inhibit gastric cancer cell activity through regulation of HuR expression ]?
### Response:
| MiR-may inhibit the gastric cancer cell activity through suppression of HuR expression. |
### Instruction:
Does habitat specificity enhance genetic differentiation in two species of aquatic Podostemaceae in Japan?
### Response:
| The high-level genetic differentiations among populations of the two species may result from their limited dispersal. Their restricted habitats, which are primarily characterized by volcanic rocks in rapids and lower temperatures in winter, may enhance isolation among populations in distant rivers. |
### Instruction:
Are subchorionic hematomas increased in early pregnancy in women taking low-dose aspirin?
### Response:
| The use of ASA may be associated with an increased risk of developing a SCH during the first trimester. The increased frequencies of SCH in pregnancies of patients attending a fertility clinic compared to women from a general obstetrical practice was highly correlated with the use of ASA. |
### Instruction:
Does rapid multiplexed phenotypic screening identify drug resistance functions for three novel efflux pumps in Acinetobacter baumannii?
### Response:
| This method has broad potential for high-throughput phenotype characterization of putative drug efflux systems in a range of organisms. |
### Instruction:
Does standard susceptibility testing overlook potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia?
### Response:
| Despite lack of activity in standard MIC testing, azithromycin synergizes with cationic peptide antibiotics to kill SM in medium mimicking tissue fluid conditions. Azithromycin, alone or in combination with colistin, merits further exploration in therapy of drug-resistant SM infections. |
### Instruction:
Is the foot function index more sensitive to change than the Leeds Foot Impact Scale for evaluating rheumatoid arthritis patients after forefoot or hindfoot reconstruction?
### Response:
| The FFI showed a large responsiveness and the LFIS- RA showed moderate responsiveness in rheumatoid arthritis patients receiving forefoot or hindfoot surgery, without floor or ceiling effects in both questionnaires. |
### Instruction:
Is sofosbuvir-based treatment safe and effective in patients with chronic hepatitis C infection and end stage renal disease : a case series?
### Response:
| Full dose sofosbuvir/simeprevir or sofosbuvir/ledipasvir therapy for HCV-infected patients with end stage renal disease was well tolerated with no discontinuation owing to side effects and no significant adverse events. |
### Instruction:
Does intraocular Pressure Reduction be Associated with Reduced Venous Pulsation Pressure?
### Response:
| Change in VPP is strongly associated with change in IOP such that a reduced intraocular pressure is associated with a subsequent reduction in VPP. This indicates that reduced IOP alters some retinal vein properties however the nature and time course of these changes is not known. |
### Instruction:
Do two di-leucine motifs regulate trafficking and function of mouse ASIC2a?
### Response:
| We identified a LLDLL sequence in the C-terminal juxtamembrane region of ASIC2a. Deleting or mutating the LLDLL sequence increased total expression and surface levels of ASIC2a in CHO cells. Mutating either of the two LL motifs had a similar effect. We further assessed ASIC2a localization in organotypic hippocampal slice neurons. The LL motif mutants exhibited increased dendritic trafficking and elevated targeting to dendritic spines. Consistent with an efficient trafficking, the LL motif mutants increased acid-activated current density. In addition, mutating the second LL motif increased pH sensitivity of the channel. These data identify the LL motifs as a negative regulator of ASIC2a trafficking and function, and suggest novel regulatory mechanisms in acid signaling. |
### Instruction:
Does transcranial Direct Current Stimulation ( tDCS ) enhance the Excitability of Trigemino-Facial Reflex Circuits?
### Response:
| This study shows that 20 minute tDCS enhances the excitability of trigemino-facial reflex circuits. The finding of larger ipsilateral than contralateral effects suggests that sensitization through cutaneous trigeminal afferents adds on other possible mechanisms such as activation of cortico-nuclear or cortico-reticular connections. |
### Instruction:
Is higher brain BDNF gene expression associated with slower cognitive decline in older adults?
### Response:
| Higher brain BDNF expression is associated with slower cognitive decline and may also reduce the deleterious effects of AD pathology on cognitive decline. |
### Instruction:
Does prior Cannabis Use be Associated with Outcome after Intracerebral Hemorrhage?
### Response:
| In this multinational cohort, cannabis use was discovered in nearly 10% of patients with spontaneous ICH. Although there was no relationship between cannabis use and specific ICH characteristics, CB+ patients had milder ICH presentation and less disability at discharge. |
### Instruction:
Is sOCS3 epigenetically up-regulated in steroid resistant nephrotic children?
### Response:
| We demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients. |
### Instruction:
Does presence of Atrial Fibrillation at the Time of Dialysis Initiation be Associated with Mortality and Cardiovascular Events?
### Response:
| Patients with AF at the time of dialysis initiation show a poor prognosis and are at high risk of cardiovascular events. Therefore, AF should be taken into consideration in dialysis patients. |
### Instruction:
Does pelvic venous congestion with castration cause chronic prostatitis in rats?
### Response:
| This rat model of pelvic congestion with castration might assist in the development of new treatments for chronic prostatitis and frequency. |
### Instruction:
Does hepatitis E Virus Contribute to Hepatic Decompensation Among Patients With Advanced Chronic Hepatitis C?
### Response:
| HEV does not appear to be a significant cause of hepatic decompensation among persons with previously stable, advanced chronic hepatitis C in the United States. |
### Instruction:
Do standard Biocompatibility Studies Predict All Effects of PVA/CMC Anti-Adhesive Gel in vivo?
### Response:
| Comparing the standardized ISO10993 methods, anti-adhesive PVA/CMC gel displays good biocompatibility. However, those methods do not seem to be sensitive enough because the rabbit abdominal wall and the end-to-end anastomosis models display more effects with respect to the dosage and routes of the intra-abdominal resorption of PVA/CMC gel - with the recommended <2 ml PVA/CMC gel per kg body weight as a secure dosage. |
### Instruction:
Does astragalus injection attenuate bleomycin-induced pulmonary fibrosis via down-regulating Jagged1/Notch1 in lungs?
### Response:
| Astragalus injection (AI, 8 g/kg) may exert protective effects on bleomycin-induced pulmonary fibrosis via downregulating Jagged1/Notch1 in lung. |
### Instruction:
Is atopic dermatitis associated with actinic keratosis : cross-sectional results from the Rotterdam study?
### Response:
| AD in community-dwelling patients is not associated with AK. |
### Instruction:
Is early indoor aeroallergen exposure associated with development of sensitization or allergic rhinitis in high-risk children?
### Response:
| Perinatal indoor aeroallergen exposure does not seem to affect development of allergic sensitization or rhinitis during childhood questioning the relevance of allergen avoidance as a preventive measure. Other factors such as timing of allergen exposure or other environmental adjuvants may contribute in a more complex pathway to sensitization. |
### Instruction:
Do iNCREASED TISSUE TRANSGLUTAMINASE LEVELS ARE ASSOCIATED WITH INCREASED EPILEPTIFORM ACTIVITY IN ELECTROENCEPHALOGRAPHY AMONG PATIENTS WITH CELIAC DISEASE?
### Response:
| We have determined an increased epileptiform activity frequency among newly-diagnosed celiac disease patients compared with formerly-diagnosed celiac disease patients and control cases. Moreover the tissue transglutaminase levels were also correlated with the presence of epileptiform activity in electroencephalography. Among newly diagnosed celiac disease patients, clinicians should be aware of this association and be alert about any neurological symptoms. |
### Instruction:
Do lOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE?
### Response:
| A high proportion of patients with inflammatory bowel disease were vitamin D deficient, particularly patients with Crohn's disease. Both clinical disease activity and quality of life correlated significantly with lower levels of vitamin D, illustrating a clear need for supplementation in patients with inflammatory bowel disease. |
### Instruction:
Are adverse events after surgery for nonmalignant colon polyps common and associated with increased length of stay and costs?
### Response:
| AEs occur in approximately one-sixth of patients after SR for complex polyps. ER-accounting for rescue SR caused by malignancy, AEs, or incomplete resection-is associated with markedly lower costs than SR. These data should be used when counseling patients about treatment options for complex polyps. |
### Instruction:
Does hSP110 T17 simplify and improves the microsatellite instability testing in patients with colorectal cancer?
### Response:
| HT17 simplifies and improves the current standard molecular methods for detecting MSI in CRC. |
### Instruction:
Is bevacizumab safe in acute relapses of neuromyelitis optica?
### Response:
| Bevacizumab is a safe add-on therapy to high-dose corticosteroids for NMO/NMO spectrum disease patients presenting with an acute relapse. |
### Instruction:
Does intermittent Hypoxia-Induced Cardiovascular Remodeling be Reversed by Normoxia in a Mouse Model of Sleep Apnea?
### Response:
| The early structural cardiovascular remodeling induced by IH was normalized after IH removal, revealing a novel recovery model for studying the effects of OSA treatment. Our findings suggest the clinical relevance of early detection and effective treatment of OSA in patients to prevent the natural course of cardiovascular diseases. |
### Instruction:
Does levo-Tetrahydropalmatine attenuate Bone Cancer Pain by Inhibiting Microglial Cells Activation?
### Response:
| This study suggests the possible clinical utility of L-THP in the treatment of bone cancer pain. The analgesic effects of L-THP on bone cancer pain maybe underlying the inhibition of microglial cells activation and proinflammatory cytokines increase. |
### Instruction:
Are miRNA expression profiles and retinal blood vessel calibers associated with short-term particulate matter air pollution exposure?
### Response:
| PM10 exposure was associated with retinal arteriolar narrowing and venular widening. PM10 exposure affected miRNAs that are involved in inflammatory and oxidative stress pathways. We suggest that miRNA changes may be relevant to explain the association between PM10 and retinal vessel calibers. |
### Instruction:
Does inhibition of succinate dehydrogenase sensitize cyclin E-driven ovarian cancer to CDK inhibition?
### Response:
| Cyclin E-driven OvCa cells appeared addicted to glucose metabolism via TCA. Combined CDKi with modalities targeting TCA, like SDHA inhibition showed promising effects for this genotype. |
### Instruction:
Is up-Regulation of Plasma miR-23b Associated with Poor Prognosis of Gastric Cancer?
### Response:
| Our results indicated that plasma miR-23b was overexpressed in GC patients and high plasma miR-23b expression was associated with poor clinical outcome. Thus, plasma miR-23b may serve as a potential diagnostic biomarker and therapeutic target for GC. |
### Instruction:
Does late-onset IgA vasculitis in adult patients exhibit distinct clinical characteristics and outcomes?
### Response:
| Patients with late-onset IgA vasculitis in adults exhibit distinct clinical features characterized by greater renal involvement and worse renal outcomes. Thus, watchful follow-up might be needed for adult IgA vasculitis patients, in particular those with late-onset disease. |
### Instruction:
Is use of Diuretics associated with mortality in patients admitted to the emergency department : results from a cross-sectional study?
### Response:
| Use of diuretics is not associated with mortality in an unselected cohort of patients presenting in an emergency room. |
### Instruction:
Does thyroid Hormone Withdrawal Further exacerbate Oxidative Stress in Patients with Thyroid Carcinoma?
### Response:
| This study showed an increased oxidative stress in patients with DTC which is further exacerbated with acute hypothyroidism upon THW. This situation may have treatment implications such as antioxidant therapy, at least during THW. |
### Instruction:
Are serum Levels of Copeptin Decreased in Gestational Diabetes Mellitus?
### Response:
| Copeptin serum levels are significantly lower in GDM as compared to healthy pregnant controls. Further studies are needed to better clarify the pathophysiological role of copeptin in GDM. |
### Instruction:
Is cavitation of intercellular spaces critical to establishment of hydraulic properties of compression wood of Chamaecyparis obtusa seedlings?
### Response:
| Our observations suggest that cavitation of intercellular spaces is the critical event that affects not only the functions of intercellular spaces but also the hydraulic properties of compression wood. |
### Instruction:
Does disease Activity Explain It All : How Internalizing Symptoms and Caregiver Depressive Symptoms Relate to Health-related Quality of Life Among Youth with Inflammatory Bowel Disease?
### Response:
| Greater DA independently relates to poorer HRQoL. In addition, DA relates to greater child internalizing problems which in turn relate to higher levels of caregiver depressive symptoms and poorer HRQoL. Providers may consider a family-based approach to screen for internalizing problems, especially in patients with active disease, because caregiver and child mood symptoms may partially explain worsening child HRQoL. |
### Instruction:
Is increased dosage of infliximab a potential cause of Pneumocystis carinii pneumonia?
### Response:
| The administration of an increased dosage of infliximab can cause Pneumocystis carinii pneumonia in CD patients. |
### Instruction:
Are genetic loci for Epstein-Barr virus nuclear antigen-1 associated with risk of multiple sclerosis?
### Response:
| Our results suggest that apart from the confirmed HLA region, the association of anti-EBNA-1 IgG titer with MS risk is also mediated through non-HLA genes, and that studies aimed at identifying genetic loci influencing EBNA immune response provides a novel opportunity to identify new and characterize existing genetic risk factors for MS. |
### Instruction:
Does novel Atraumatic End-to-Side Repair Model exhibit Robust Collateral Sprouting Independent of Donor Fiber Injury?
### Response:
| The authors' findings provide strong evidence that collateral sprouting can be robustly initiated independent of donor nerve fiber injury. The authors' model can accelerate the understanding of the mechanism underlying end-to-side neurorrhaphy and the optimization of its clinical use. |
### Instruction:
Is a new allele conferring resistance to Lysinibacillus sphaericus detected in low frequency in Culex quinquefasciatus field populations?
### Response:
| The cqm1 REC-2 allele occurs in populations in Recife and was probably already present in the samples used to establish the laboratory resistant colony. The data generated indicates that cqm1 REC-2 can be selected in field populations, although its low frequency and distribution in Recife suggest that cqm1 REC-2 presents a lower risk of selection compared to cqm1 REC . |
### Instruction:
Is tobacco smoking associated with DNA methylation of diabetes susceptibility genes?
### Response:
| Tobacco smoking is associated with differential DNA methylation of the diabetes risk genes ANPEP, KCNQ1 and ZMIZ1. Our study highlights potential biological mechanisms connecting tobacco smoking to excess risk of type 2 diabetes. |
### Instruction:
Do effects of Hand Fellowship Training on Rates of Endoscopic and Open Carpal Tunnel Release?
### Response:
| Within the United States from 2003 to 2013, the rate of ECTR increased, as did complications. However, complication rates remained low in the first 2 years of practice. Hand fellowship-trained surgeons performed more ECTR than did non-hand fellowship-trained orthopedic surgeons, and both groups had similar complication rates. |
### Instruction:
Does androgen ablation elicit PP1-dependence for AR stabilization and transactivation in prostate cancer?
### Response:
| As summarized in a simplified model, our studies defined an essential PP1-mediated pathway for AR protein stabilization that can compensate the loss of androgen and established a mechanistic link between PP1 and androgen responsiveness. The amplified PP1-dependence for AR activation under the androgen ablated conditions provides a rationale to therapeutically target the PP1-AR module in the castration-resistant prostate cancer (CRPC). Our findings also suggested an alternative AR-targeting compounds screening strategy that aims to circumvent PP1-AR interaction. |
### Instruction:
Does eye-tracking reveal a slowdown of social context processing during intention attribution in patients with schizophrenia?
### Response:
| Difficulty may not have been equivalent between intention attribution and physical reasoning conditions. |
### Instruction:
Are cerebrospinal Fluid Markers of Alzheimer 's Disease Pathology and Microglial Activation Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer 's Disease?
### Response:
| Inflammation may play a role in neural damage in preclinical AD. |
### Instruction:
Do leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts?
### Response:
| We conclude that leptin selectively enhances the expression and secretion of certain matrix metalloproteinases in human gingival fibroblasts, and suggest that gingival fibroblasts may have an ECM-degrading phenotype during conditions of hyperleptinaemia (e.g., obesity, type 2 diabetes mellitus, exogenous leptin therapy). |
### Instruction:
Does low oxygen tension reverse antineoplastic effect of iron chelator deferasirox in human glioblastoma cells?
### Response:
| Taken together, these in vitro results could raise the question of the benefit of using iron chelators in their native forms under the hypoxic conditions often encountered in solid tumors such as GBM. Developing new chemistry or a new drug delivery system that would keep DFX active in hypoxic cells may be the next step toward their application. |
### Instruction:
Does recombinant Mouse β-Defensin 3 protect against Coxsackievirus B3-Induced Myocarditis in Mice?
### Response:
| rMBD3 was demonstrated to possess anti-CVB3 activity in vivo and in vitro. |
### Instruction:
Is neuroinflammation Associated with Brain Extracellular TAU-Protein Release after Spontaneous Subarachnoid Hemorrhage?
### Response:
| Neuroinflammation after aSAH is associated with intraparenchymal bleeding, deranged cerebral metabolism and TAU-protein release. The impact of potential anti-inflammatory treatment strategies on secondary brain injury after aSAH has to be investigated in future studies. |
### Instruction:
Does activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha facilitate Lymphangiogenesis in Lacrimal Glands in Dry Eye?
### Response:
| Dll4/Notch signaling and HIF-1α are closely related to lymphangiogenesis in DE-induced LGs. Lymphangiogenesis stimulated by Dll4/Notch and HIF-1α may play a role in protecting LGs from DE-induced inflammation by aiding the clearance of immune cells from LGs. |
### Instruction:
Do long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans?
### Response:
| A comprehensive annotation of lncRNAs is known to require an approach that is sensitive to low and tight tissue-specific expression. Here we show that increased inter-individual expression variability is an additional general lncRNA feature to consider when creating a comprehensive annotation of human lncRNAs or proposing their use as prognostic or disease markers. |
### Instruction:
Do endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes?
### Response:
| In a small muscular artery of mice of either sex, total endothelium-dependent relaxation is not affected by age. However, possibly due to changes in KCa channel function, the contribution of EDH to endothelium-dependent relaxations decreased with age. The contribution of endothelium-derived NO increases in old male mice. |
### Instruction:
Are elevated plasma fractalkine levels associated with higher levels of IL-6 , Apo-B , LDL-C and insulin , but not with body composition in a large female twin sample?
### Response:
| Higher FRACT levels correlated with elevated levels of IL-6, Apo-B, LDL-C and insulin, all known risk factors for several clinical related diseases suggesting a potential role of FRACT in inflammation and tissue injury. Variations of FRACT levels are not influenced by body composition and are not correlated with leptin indicating that fat mass alone is not responsible for elevation of FRACT seen in obese individuals. |
### Instruction:
Are laryngeal physiology and voice acoustics maintained after minimally invasive parathyroidectomy?
### Response:
| MIP can be performed with exquisite disease control and without significant effects on laryngeal physiology or voice acoustic measures. For the first time, both physiologic and acoustic data support the use of MIP. |
### Instruction:
Does aIM2 facilitate the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation?
### Response:
| Our results implied that AIM2 might act as an important DNA sensor and a potential biomarker for apopDNA-induced macrophage functional maturation and SLE disease. |
### Instruction:
Do nLRP3 inflammasomes show high expression in aorta of patients with atherosclerosis?
### Response:
| NLRP3 was overexpressed in aorta of patients with coronary atherosclerosis and the aortic NLRP3 expression is correlated with the severity of coronary artery disease and the atherosclerotic risk factors. |
### Instruction:
Do low agarose concentration and TGF-β3 distribute extracellular matrix in tissue-engineered cartilage?
### Response:
| Culturing with no or low agarose concentrations and TGF-β3 is favorable for cartilage tissue-engineering studies, because both stimulate the formation of a more homogeneous ECM and consequently result in improved mechanical properties. |
### Instruction:
Are many response criteria poor predictors of outcomes after cardiac resynchronization therapy : validation using data from the randomized trial?
### Response:
| Only some of the commonly used response criteria predict outcome in patients undergoing CRT. The predictive value varies substantially across different criteria, with a higher sensitivity observed for the clinical parameters and a higher specificity observed for echocardiographic parameters. Combining various criteria adds little to their prognostic value. The predictive accuracy of various criteria can be different in various subgroups due to multiple interactions with baseline characteristics. CLINICALTRIALS. GOV IDENTIFIER: NCT00814840. |
### Instruction:
Is tV time but not computer time associated with cardiometabolic risk in Dutch young adults?
### Response:
| We found a significantly positive association of TV time with cardiometabolic biomarkers. In addition, we found no evidence for WC as a mediator of this association. Our findings suggest a need to distinguish between TV time and computer time within future guidelines for screen time. |
### Instruction:
Are hSP27 expression levels associated with the sensitivity of hepatocellular carcinoma cells to 17-allylamino-17-demethoxygeldanamycin?
### Response:
| 17AAG inhibited the viability of hepatocellular carcinoma cells by degrading Hsp90 client proteins. The sensitivity of cells to 17AAG is associated with the level of Hsp27 expression. |
### Instruction:
Are genetic variants of phosphodiesterase 4D gene associated with an enhanced risk for ischemic stroke in young Chinese population?
### Response:
| Our findings suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D gene are significantly associated with IS in Chinese young population. |
### Instruction:
Does hypothermia prevent gliosis and angiogenesis development in an experimental model of ischemic proliferative retinopathy?
### Response:
| This work demonstrates that aberrant angiogenesis and exacerbated gliosis seem to be responsible for the increased thickness of the inner retina as a consequence of perinatal asphyxia, and that hypothermia is able to prevent these alterations. |
### Instruction:
Is fibroblast growth factor receptor 2c signaling required for intestinal cell differentiation in zebrafish?
### Response:
| In conclusion, we found that Fgfr2c signaling derived from mesenchymal cells is important for regulating the differentiation of zebrafish intestine epithelial cells by promoting cell cycle exit. The results of Fgfr2c knockdown in mib(ta52b) mutants indicated that Fgfr2c signaling is required for intestinal cell differentiation. These findings provide new evidences that Fgf signaling is required for the differentiation of intestinal cells in the zebrafish developing gut. |
### Instruction:
Does a novel low-molecular-weight compound enhance ectopic bone formation and fracture repair?
### Response:
| A single local dose of a low-molecular-weight compound, SVAK-12, enhanced bone-healing in the presence of low-dose exogenous rhBMP-2 (in the ectopic model) and endogenous rhBMPs (in the femoral fracture model). |
### Instruction:
Does sorafenib enhance radiation-induced apoptosis in hepatocellular carcinoma by inhibiting STAT3?
### Response:
| These results indicate that sorafenib sensitizes resistant HCC cells to radiation-induced apoptosis via downregulating phosphorylation of STAT3 in vitro and in vivo. |
### Instruction:
Does aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predispose to anxiety and alcoholism?
### Response:
| These novel data demonstrate the role of HDAC2-mediated epigenetic mechanisms in anxiety and alcoholism. |
### Instruction:
Does outdoor activity during class recess reduce myopia onset and progression in school children?
### Response:
| Outdoor activities during class recess in school have a significant effect on myopia onset and myopic shift. Such activities have a prominent effect on the control of myopia shift, especially in nonmyopic children. |
### Instruction:
Do animal studies trigger new insights on the use of methadone maintenance?
### Response:
| SSM reduces cocaine intake, blocks cocaine seeking and normalizes expression of genes known to regulate cocaine seeking. These findings suggest that SSM could be an effective pharmacological agent to assist cocaine detoxification and prevention of relapse to cocaine abuse in individuals not co-dependent on opioid. |
### Instruction:
Are elevated B lymphocyte stimulator levels associated with increased damage in an Irish systemic lupus erythematosus cohort?
### Response:
| BLyS blockade may be most beneficial if introduced early in the course of disease in young Caucasian patients presenting with renal, musculoskeletal and skin disease in an effort to reduce long-term damage. |
### Instruction:
Do an update review on HPV testing methods for cervical neoplasia?
### Response:
| The main HPV testing methods that have well-defined clinical applications at present are polymerase chain reaction (PCR) and Hybrid Capture II. Real-time PCR and mRNA testing are techniques of growing interest. The main clinical applications are in the triage of borderline Pap smears and in the follow-up after treatment for cervical pre-malignant lesions. Other applications such as use in primary screening are under consideration. |
### Instruction:
Does comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveal extensive diversity and region-specific polymorphisms?
### Response:
| We demonstrate that there is extensive kinesin genetic diversity among strains in East Africa and between East Africa and South Asia, with ample scope for influencing performance of rK39 diagnostic assays. We also show the importance of targeted comparative genomics in guiding optimisation of recombinant/synthetic diagnostic antigens. |
### Instruction:
Does aprikalim a potassium adenosine triphosphate channel opener reduce neurologic injury in a rabbit model of spinal cord ischemia?
### Response:
| Aprikalim reduces the severity of spinal cord ischemic injury in a rabbit model of spinal cord ischemia. |
### Instruction:
Are stents associated with increased risk of respiratory infections in patients undergoing airway interventions for malignant airways disease?
### Response:
| Therapeutic bronchoscopy with stent placement is associated with a higher risk of infection than is therapeutic bronchoscopy alone. If ablative techniques reopen the airway and there is a good chance that the tumor may respond to chemotherapy and/or radiation, a strategy of initially holding off on stenting may be warranted. |
### Instruction:
Does preoperative infliximab therapy increase morbidity and mortality after laparoscopic resection for inflammatory bowel disease?
### Response:
| This study is subject to the limitations of a retrospective design. |
### Instruction:
Does gefitinib enhance the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells?
### Response:
| Gefitinib can inhibit ABCG2-mediated PpIX efflux from malignant brain tumor cells to increase the intracellular PpIX and thereby enhance the PDT effect. |
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