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### Instruction:
Is corticotropin-releasing factor present in intestinal tissue of patients with gastrointestinal dysfunction following shock and abdominal surgery?
### Response:
| The novel finding is the presence of CRF in the small bowel of both elective and emergency gastrointestinal surgery patients with concomitant gastrointestinal dysfunction. Circulating CRF is associated with poor gastric emptying, which prolongs ICU stay, whereas shock significantly impairs gastric emptying and gut permeability. |
### Instruction:
Is reduction of Plasma MicroRNA-21 Associated with Chemotherapeutic Response in Patients with Non-small Cell Lung Cancer?
### Response:
| Plasma miR-21 is a good biomarker for NSCLC, and could be used to predict responses to chemotherapy. |
### Instruction:
Do treatment of neck port-wine stain with intense pulsed light in Chinese population?
### Response:
| IPL is effective in neck PWS of Chinese population. Adverse effects were minimal and acceptable. |
### Instruction:
Does valgus hip with high antetorsion cause pain through posterior extraarticular FAI?
### Response:
| Valgus hips with increased antetorsion predispose to posterior extraarticular FAI and to a lesser degree anteroinferior spine impingement. |
### Instruction:
Is nurse-patient interaction a resource for hope , meaning in life and self-transcendence in nursing home patients?
### Response:
| Nurse-patient interaction influences hope, meaning in life and self-transcendence in cognitively intact nursing home patients and might be an important resource in relation to patients' health and global well-being. Thus, care providers are above all fundamental for nursing home patients. Advancing caregivers' interacting and communicating skills might facilitate patients' health and global well-being and inspire professional caregivers as they perform their daily care practices. More research of the effectiveness of such strategies is greatly needed. |
### Instruction:
Are high medial plantar pressures during barefoot running associated with increased risk of ankle inversion injury in Royal Marine recruits?
### Response:
| The findings from this study support existing literature, providing evidence that high medial concentration of vertical forces when running are associated with increased ankle inversion injury risk. This may be due to the lateral ankle ligaments being less accustomed to loading, resulting in relatively weak lateral ligaments, or ligaments less able to deal with fatigue than those of the control group. |
### Instruction:
Do an update on using vitamin E in Alzheimer 's disease?
### Response:
| Supplementation of AD patients with vitamin E increases its levels in biological fluids and decreases their susceptibility to oxidative stress. However, clinical interventional and observational studies demonstrated contradicting results regarding the benefit of vitamin E in AD. Available data do not provide any clear evidence that vitamin E beneficially influences AD and are not sufficient to recommend vitamin E for primary or secondary prevention of AD. The future of vitamin E supplementation in AD should be therefore regarded with caution. |
### Instruction:
Is repeated transanal endoscopic microsurgery feasible and safe?
### Response:
| Repeated TEM is feasible and safe and may be appropriate for selected patients. |
### Instruction:
Are color and spatial frequency related to visual pattern sensitivity in migraine?
### Response:
| Color, independent of luminance or particular color contrasts, can have therapeutic effects for people with visually triggered migraine as it can reduce the number of perceived illusions when viewing stripes or text. The effect was not color-specific and was greatest for the 12 cpd gratings. Given the significant associations between the achromatic discomfort measures and reports of visual triggers, and the lack of significant associations between the chromatic discomfort measures and reports of visual triggers, further research is recommended to explore the potential to reduce the number of visually triggered migraines with color in addition to alleviating visual discomfort. |
### Instruction:
Does apical CFTR expression in human nasal epithelium correlate with lung disease in cystic fibrosis?
### Response:
| CFTR expression in nasal epithelial cells is lower in subjects with CF compared to healthy subjects. The proportion of cells expressing F508del-CFTR at the apical membrane is variable between subjects and is positively correlated with FEV1% in F508del-CFTR homozygous subjects. |
### Instruction:
Do even low physical activity levels improve vascular function in overweight and obese postmenopausal women?
### Response:
| Even low-intensity PA improves antioxidant capacity, RHR, and saRHI in postmenopausal women. Advising postmenopausal women to increase their PA at any level seems warranted based on our preliminary and hypothesis-generating data. |
### Instruction:
Is while systolic cardiomyocyte function preserved , diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice?
### Response:
| Inhibition of CaMKIIδ appears to be safe under basal physiologic conditions. Specific conditions exist (e.g. during acidosis) under which CaMKII-inhibition might not be helpful or even detrimental. These conditions will have to be more clearly defined before CaMKII inhibition is used therapeutically. |
### Instruction:
Does iL28B polymorphism correlate with active hepatitis in patients with HBeAg-negative chronic hepatitis B?
### Response:
| HBV viral load and IL28B rs10853728 CC genotype correlated with hepatitis activity in HBeAg-positive and HBeAg-negative CHB, respectively. Both viral and host factors play roles in disease activity during different phases of CHB. |
### Instruction:
Is public perception of epilepsy in dogs more favorable than in humans?
### Response:
| These findings shed light on the variation in perceptions of seizures in dogs, which are interestingly more sympathetic towards dogs with epilepsy than towards humans with epilepsy. This highlights the potential future use of YouTube in investigating public views as well as in informing and educating. |
### Instruction:
Is soluble TWEAK associated with atherosclerotic burden in patients with chronic kidney disease?
### Response:
| A significant reduction in sTWEAK and increment in CD163 plasma levels were observed in patients with more severe atherosclerosis. Our results indicate that sTWEAK could be a novel biomarker of atherosclerotic burden in CKD patients. |
### Instruction:
Does angiopoietin-2 modulate eEOC-mediated renoprotection in AKI in a dose-dependent manner?
### Response:
| Ang-2 acts as modulator of eEOCs in AKI. The migration analysis indicates that the Ang-2 significantly alters indirect (paracrine) activity of eEOCs, thus promoting renoprotection in a dose-dependent manner. |
### Instruction:
Is the interleukin-6 -147 g/c polymorphism associated with increased risk of coronary artery disease in young South African Indian men?
### Response:
| The presence of the IL-6 -174 G allele influences levels of IL-6 and increases the risk of CAD in South African Indians. |
### Instruction:
Is an elevated maternal serum C-reactive protein in the context of intra-amniotic inflammation an indicator that the development of amnionitis , an intense fetal and AF inflammatory response are likely in patients with preterm labor : clinical implications?
### Response:
| An elevated maternal serum CRP concentration in the context of IAI is an indicator that the development of amnionitis, an intense fetal and AF inflammatory response are likely in patients with PTL. |
### Instruction:
Does health-related quality of life predict mortality in idiopathic pulmonary fibrosis?
### Response:
| There was no significant relationship between HRQL evaluated with the SGRQ and the subsequent mortality in IPF. The present negative result might suggest that HRQL is measuring an aspect other than one from physiological and functional impairment or disability. |
### Instruction:
Does right ventricle best predict the race performance in amateur ironman athletes?
### Response:
| In amateur IM-ATHL, RV end-diastolic area and percent body fat were independently related to race performance. RV end-diastolic area was the strongest predictor of race time. The role of the RV in endurance exercise may thus be more important than previously thought and needs to be further studied. |
### Instruction:
Does salubrinal reduce expression and activity of MMP13 in chondrocytes?
### Response:
| The results demonstrate that salubrinal downregulates expression and activity MMP13 through p38 and NFκB signaling, suggesting its potential usage to treat degenerative diseases such as osteoarthritis. |
### Instruction:
Do overweight and obese cardiac patients have better prognosis despite reporting worse perceived health and more conventional risk factors?
### Response:
| Overweight and obese CVD patients have better prognosis despite reporting worse health, more co-morbidities and risk factors, and poorer adherence to lifestyle advice. |
### Instruction:
Is exercise therapy evidence-based treatment of shoulder impingement syndrome . Current practice or recommendation only?
### Response:
| About half of patients reported that they had not received advice for rotator cuff exercise therapy before surgery even though with it surgery would probably have been avoided in many cases. Although symptoms in most patients had decreased after operation, several patients still suffered from pain and decreased function. Still several patients had not received advice for shoulder strengthening exercises that are important to recovery. |
### Instruction:
Is loss of constitutive activity correlated with increased thermostability of the human adenosine A2A receptor?
### Response:
| The loss of constitutive activity may be an important feature of these thermostabilized GPCRs. In addition, the constitutively active and agonist-induced active conformations of the A(2A)R are distinct. |
### Instruction:
Is high dietary magnesium intake associated with low insulin resistance in the Newfoundland population?
### Response:
| The results of this study indicate that higher dietary magnesium intake is strongly associated with the attenuation of insulin resistance and is more beneficial for overweight and obese individuals in the general population and pre-menopausal women. Moreover, the inverse correlation between insulin resistance and dietary magnesium intake is stronger when adjusting for %BF than BMI. |
### Instruction:
Does multidrug resistance-associated protein 1 decrease the concentrations of antiepileptic drugs in cortical extracellular fluid in amygdale kindling rats?
### Response:
| Up-regulation of MRP1 is responsible for the resistance of brain cells to antiepileptic drugs in the amygdale kindling rats. |
### Instruction:
Does inhibition of Hec1 expression enhance the sensitivity of human ovarian cancer cells to paclitaxel?
### Response:
| Hec1 overexpression is associated with the progression and poor prognosis of ovarian cancer. Inhibition of Hec1 expression can sensitize ovarian cancer cells to paclitaxel. |
### Instruction:
Does treatment with hydrogen sulfide alleviate streptozotocin-induced diabetic retinopathy in rats?
### Response:
| Treatment with H₂S alleviates STZ-induced diabetic retinopathy in rats possibly through abating oxidative stress and suppressing inflammation. |
### Instruction:
Does preoperative delay of more than 1 hour increase the risk of surgical site infection?
### Response:
| Preoperative in-room time prior to the start of surgical incision is an independent risk factor for SSI. All possible steps should be taken prior to entry into the operating theater to reduce in-room time and opening of surgical sterile instrumentation be delayed until the surgery is ready to proceed. |
### Instruction:
Are glucose-6-phosphate dehydrogenase deficient variants associated with reduced susceptibility to malaria in the Brazilian Amazon?
### Response:
| G6PD enzyme activity was directly related to susceptibility to malaria in the Brazilian Amazon, where P. vivax predominates. Severe G6PDd was associated with considerable higher risk of malaria-related transfusions. |
### Instruction:
Are mutations in genes encoding cardiac ion channels previously associated with sudden infant death syndrome ( SIDS ) present with high frequency in new exome data?
### Response:
| A very high prevalence of previously SIDS-associated variants was identified in exome data from population studies. Our findings indicate that the suggested disease-causing role of some of these variants is questionable. A cautious interpretation of these variants must be made when found in SIDS victims. |
### Instruction:
Is the allosteric modulation of thyroxine-binding globulin affinity entropy driven?
### Response:
| TBG allosteric regulation is entropy driven. The presence of multiple S states may allow more efficient T4 release due to protease activity. |
### Instruction:
Is blood transfusion requirement during liver transplantation an important risk factor for mortality?
### Response:
| Intraoperative blood transfusion requirement is an important risk factor for mortality after liver transplantation. The strongest risk factors for intraoperative blood transfusion requirement are warm ischemia time and bilirubin levels. Intraoperative blood loss and its risk factors should be incorporated into models to predict survival after liver transplantation. |
### Instruction:
Does fuyuan Decoction inhibit nitric oxide production via inactivation of nuclear factor-κB in SW1353 chondrosarcoma cells?
### Response:
| These findings suggested that FYD could inhibit NO production and iNOS expression in IL-1β-induced chondrocytes through suppressing NF-κB activation. |
### Instruction:
Are microvesicle protein levels associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease?
### Response:
| Cystatin C, Serpin F2 and CD14 MV levels are related to an elevated risk for future vascular events and mortality in patients with clinically manifest vascular disease. |
### Instruction:
Is coxa profunda a useful radiographic parameter for diagnosing pincer-type femoroacetabular impingement?
### Response:
| Coxa profunda should be considered a normal radiographic finding, at least in females. Coxa profunda is a nonspecific radiographic finding, seen in a variety of hip disorders and asymptomatic hips. The presence of coxa profunda is neither necessary nor sufficient to support a diagnosis of pincer-type femoroacetabular impingement. |
### Instruction:
Does inhibition of proteasomal glucocorticoid receptor degradation restore dexamethasone-mediated stabilization of the blood-brain barrier after traumatic brain injury?
### Response:
| The results indicate that the stabilizing effect of glucocorticoids on the blood-brain barrier is hampered after cerebral lesions by proteasomal glucocorticoid receptor degradation in brain endothelial cells and restored by inhibition of proteasomal degradation pathways. The results provide underlying mechanisms for the clinically observed inefficacy of glucocorticoids. The novel combined treatment strategy might help to attenuate trauma-induced brain edema formation and neuronal damage as secondary effects of brain trauma. |
### Instruction:
Are oestrogen receptors prognostic factors in malignant peritoneal mesothelioma?
### Response:
| The presence of ER-β (cytoplasm) is associated with poor prognosis. The favourable survival association observed in patients with ER-β (nuclear) raises a question about the molecular mechanisms of the tumorigenic roles of ER-β in each cellular compartment and requires further studies. |
### Instruction:
Does the prognostic nutritional index predict long-term outcomes of gastric cancer patients independent of tumor stage?
### Response:
| The PNI is a simple and useful marker for predicting the long-term outcomes of gastric cancer patients independent of the tumor stage. Based on our results, we suggest that the PNI should be included in the routine assessment of gastric cancer patients. |
### Instruction:
Does long interspersed nuclear element ORF-1 protein promote proliferation and resistance to chemotherapy in hepatocellular carcinoma?
### Response:
| LINE-1 ORF-1p promotes HepG2 cell proliferation and plays an important role in the resistance of chemotherapeutic drugs. By establishing novel roles and defining the mechanisms of LINE-1 ORF-1p in HCC chemotherapeutic drug resistance and cell proliferation regulation, this study indicates that LINE-1 ORF-1p is a potential target for overcoming HCC chemotherapeutic resistance. |
### Instruction:
Do chloride channel blockers suppress formation of engulfment pseudopodia in microglial cells?
### Response:
| These findings indicate that I(Cl,swell) contributes to formation of engulfment pseudopodia and participates in engulfment and particle uptake in microglial cells. |
### Instruction:
Do prevalence and risk factors for penile lesions/anomalies in a cohort of Brazilian men ≥ 40 years of age?
### Response:
| We estimated the prevalence and risk factors of commonly seen penile diseases in an adult cohort of Brazilian men. |
### Instruction:
Are prevalent and incident bacterial vaginosis associated with sexual and contraceptive behaviours in young Australian women?
### Response:
| This paper presents BV and AF prevalence and incidence estimates from a large prospective cohort of young Australian women predominantly recruited from primary-care clinics. These data support the concept that sexual activity is strongly associated with the development of BV and AF and that use of an OCC is associated with reduced risk. |
### Instruction:
Do adherent culture conditions enrich the side population obtained from the cochlear modiolus-derived stem/progenitor cells?
### Response:
| Employment of an adherent culture system, instead of a suspension culture system, resulted in the enrichment of the SP cells from SPCs while retaining their stemness and multipotency. |
### Instruction:
Does health information exchange reduce repeated diagnostic imaging for back pain?
### Response:
| Health information exchange use is associated with 64% lower odds of repeated diagnostic imaging in the emergency evaluation of back pain. Health information exchange effect on estimated costs was negligible. More studies are needed to evaluate specific strategies to increase health information exchange use and further decrease potentially unnecessary diagnostic imaging and associated costs of care. |
### Instruction:
Is semaphorin 3A a new early diagnostic biomarker of experimental and pediatric acute kidney injury?
### Response:
| Our results suggest that semaphorin 3A is an early, predictive biomarker in experimental and pediatric AKI, and may allow for the reliable early diagnosis and prognosis of AKI after CPB, much before the rise in serum creatinine. |
### Instruction:
Does alteration of the E-Cadherin/β-Catenin Complex be an Independent Poor Prognostic Factor in Lung Adenocarcinoma?
### Response:
| The alteration of the expression of the E-cadherin/β-catenin complex was associated with aggressive tumor behavior in lung adenocarcinoma. |
### Instruction:
Does the ROCK inhibitor eye drop accelerate corneal endothelium wound healing?
### Response:
| These findings show that rock inhibitor Y-27632 eye drops promote corneal endothelial wound healing in a primate animal model and suggest the possibility of Y-27632 as a novel therapeutic modality for certain forms of corneal endothelial dysfunction. (http://www.umin.ac.jp/ctr/ number, UMIN000003625.). |
### Instruction:
Is stem cell therapy a promising tool for refractory angina : a meta-analysis of randomized controlled trials?
### Response:
| Stem cell therapy appears to be effective and safe in the management of patients with refractory angina. The findings need confirmation in larger-scale studies with longer follow-up. |
### Instruction:
Do neuropsychological dysfunction in idiopathic hypoparathyroidism and its relationship with intracranial calcification and serum total calcium?
### Response:
| Neuropsychological dysfunctions are present in up to one-third of patients with IH and correlate with duration of illness, female gender, serum calcium and calcium-phosphorus product during follow-up but not with intracranial calcification. These dysfunctions may affect their daily functions, safety and drug compliance. |
### Instruction:
Does keratinocyte growth factor pretreatment prevent radiation-induced intestinal damage in a mouse model?
### Response:
| KGF pretreatment could improve radiation-induced intestinal injury including the epithelial structure and function in a mouse model. |
### Instruction:
Is high-sensitivity troponin T a prognostic marker for patients with aortic stenosis after valve replacement surgery?
### Response:
| hs-TnT can be a prognostic marker for patients with AS after valve replacement surgery. |
### Instruction:
Does autophagy inhibition promote gambogic acid-induced suppression of growth and apoptosis in glioblastoma cells?
### Response:
| Our results suggested that autophagic responses play roles as a self-protective mechanism in GA-treated glioblastoma cells, and autophagy inhibition could be a novel adjunctive strategy for enhancing chemotherapeutic effect of GA as an anti-malignant glioma agent. |
### Instruction:
Does left ventricular dyssynchrony predict clinical response to CRT - a long-term follow-up single-center prospective observational cohort study?
### Response:
| LVD at baseline as assessed by a straightforward echocardiographic approach predicts the long-term clinical response to CRT and is associated with a more pronounced reverse LV remodeling. |
### Instruction:
Does pinellia ternata Breitenbach attenuate ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma?
### Response:
| These results indicate that PTE has protective effects against allergic airway inflammation. |
### Instruction:
Is dental phobia no contraindication for oral implant therapy?
### Response:
| Implant therapy can be successfully performed in DP patients with PDPT as phobia is not negatively influenced by the invasive implant therapy. However, motivation for professional maintenance programs remains challenging. |
### Instruction:
Does atoh1 induce auditory hair cell recovery in mice after ototoxic injury?
### Response:
| Ad28.gfap.atoh1 promotes hair cell regeneration in cochlea ablated with kanamycin and furosemide resulting in moderate hearing recovery. |
### Instruction:
Does prevalence of psychoses in Stockholm County -- a population-based study using comprehensive healthcare register?
### Response:
| The 1-year prevalence of schizophrenia was 3.7/1000 and approximately twice as high for non-affective psychoses. The estimates were stable over time but varied substantially between local areas, corresponding to social and demographic factors. |
### Instruction:
Do commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods?
### Response:
| These results strongly support the current view that gut microorganisms modulate brain development and behavior. |
### Instruction:
Does parenteral nutrition increase susceptibility of ileum to invasion by E coli?
### Response:
| The data illustrate EVISC as a reproducible model for studying host-pathogen interactions and the effects of diet on susceptibility to infections. Specifically, the findings support our hypothesis that PN with the lack of enteral feeding decreases mucosal responsiveness to pathogen exposure and provides a plausible mechanism by which PN is associated with increased risk of infectious complication. |
### Instruction:
Does myocardial infarction cause inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus?
### Response:
| We conclude that in addition to local inflammation, AMI results in remote organ inflammation evidenced by (1) increased expression of mRNA for inflammatory cytokines, (2) marked upregulation of VCAM-1 in renal glomeruli, and (3) the recruitment and infiltration of leukocytes in the kidney. |
### Instruction:
Does ezetimibe inhibit hepatic Niemann-Pick C1-Like 1 to facilitate macrophage reverse cholesterol transport in mice?
### Response:
| In mice lacking intestinal cholesterol absorption, macrophage-to-feces RCT depends on efficient biliary sterol secretion, and ezetimibe promotes macrophage RCT by inhibiting hepatic NPC1L1 function. |
### Instruction:
Does inhalation exposure of nano-scaled titanium dioxide ( TiO2 ) particles alter the inflammatory responses in asthmatic mice?
### Response:
| We conclude that inhalation of TiO2 may aggravate respiratory diseases and that the adverse health effects are highly dependent on dose and timing of exposure. Our data imply that inhalation of NPs may increase the risk for individuals with allergic airway disease to develop symptoms of severe asthma. |
### Instruction:
Does aMP-activated protein kinase regulate endothelial cell angiotensin-converting enzyme expression via p53 and the post-transcriptional regulation of microRNA-143/145?
### Response:
| AMPKα2 suppresses endothelial ACE expression via the phosphorylation of p53 and upregulation of miR-143/145. Post-transcriptional regulation of miR-143/145 may contribute to the vascular complications associated with diabetes mellitus. |
### Instruction:
Do teachers ' ratings of childhood behaviours predict adolescent and adult crime among 3016 males and females?
### Response:
| Teachers in elementary schools rated behaviours that, from age 6 onward, significantly predicted criminal convictions into early adulthood. |
### Instruction:
Does repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduce nicotine cue craving?
### Response:
| One session of high-frequency rTMS (10 Hz) of the left DLPFC significantly reduced subjective craving induced by smoking cues in nicotine-dependent participants. Additional studies are needed to explore rTMS as an aid to smoking cessation. |
### Instruction:
Is pI3K/AKT signaling essential for communication between tissue-infiltrating mast cells , macrophages , and epithelial cells in colitis-induced cancer?
### Response:
| The PI3K/AKT pathway is active in cells infiltrating inflamed human colon tissue. This pathway sustains the recruitment of inflammatory cells through a positive feedback loop. The PI3K/AKT pathway is essential for tumor invasion and the malignant features of the piroxicam/IL-10(-/-) mouse model. LY294002 targets the PI3K pathway and hinders progressive colitis. These findings indicate that colitis and progression to cancer are dependent on stromal PI3K and sensitive to treatment with LY294002. |
### Instruction:
Does carvedilol treatment after myocardial infarct decrease cardiomyocytic apoptosis in the peri-infarct zone during cardioplegia-induced cardiac arrest?
### Response:
| In the failed heart, pretreatment with carvedilol could preserve cardiac contractility during cardioplegia-induced myocardial H/R injury by lessening inflammation-related genes and expression of cytokines, decreasing apoptosis-related proteins production and diminishing the occurrence of cardiomyocytic apoptosis in the peri-infarct zone. The cardinal pathways of the antiapoptotic mechanism of carvedilol were PI3K- and MEK-related pathways. |
### Instruction:
Is expression of MMP-13 associated with invasion and metastasis of papillary thyroid carcinoma?
### Response:
| The data suggest that MMP-13 is associated with thyroid tumour invasion and metastasis and it may be a potential target for therapeutic intervention. |
### Instruction:
Does activation of midbrain and ventral striatal regions implicate salience processing during a modified beads task?
### Response:
| Our data show that probabilistic reasoning shares neural substrates with executive functions. In addition, our finding that brain regions commonly associated with salience processing are active during probabilistic reasoning identifies a candidate mechanism that could underlie the behavioral link between dopamine-dependent aberrant salience and JTC in schizophrenia. Further studies with delusional schizophrenia patients will have to be performed to substantiate this link. |
### Instruction:
Is high expression of Lewis y antigen and CD44 correlated with resistance to chemotherapy in epithelial ovarian cancers?
### Response:
| Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients. |
### Instruction:
Does contralateral occlusion of the internal carotid artery increase the risk of patients undergoing carotid endarterectomy?
### Response:
| Patients undergoing CEA in the presence of an occluded contralateral carotid artery had increased perioperative and early postoperative risk. Our analysis is limited by heterogeneity in symptom status and practices of intraoperative cerebral protection among the studies. Careful consideration should be given in this subgroup of patients with regard to selection and perioperative and postoperative care to minimize the risk. |
### Instruction:
Does nine months of combined training improve ex vivo skeletal muscle metabolism in individuals with type 2 diabetes?
### Response:
| Nine months of AT and RT significantly improved most aspects of skeletal muscle mitochondrial content and substrate oxidation, whereas the combination improved all aspects. These exercise responses were associated with clinical improvements, indicating that long-term training, especially combination, is an effective lifestyle therapy for individuals with T2D by way of improving muscle substrate metabolism. |
### Instruction:
Does long noncoding RNAs associated with liver regeneration 1 accelerate hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling?
### Response:
| lncRNA-LALR1 promotes cell cycle progression and accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling. Pharmacological intervention targeting lncRNA-LALR1 may be therapeutically beneficial in liver failure and liver transplantation by inducing liver regeneration. |
### Instruction:
Does hepatitis B virus inhibit liver regeneration via epigenetic regulation of urokinase-type plasminogen activator?
### Response:
| Taken together, these results suggest that infection of HBV impairs liver regeneration through the epigenetic dysregulation of liver regeneration signals by HBx. |
### Instruction:
Are polymorphisms of the HTR3B gene associated with post-surgery emesis in a Chinese Han population?
### Response:
| The HTR3B rs3758987 SNP might serve as a predictor of post-operative vomiting in Chinese Han patients undergoing gynaecological laparoscopic surgery. |
### Instruction:
Are both total testosterone and sex hormone-binding globulin independent risk factors for metabolic syndrome : results from Fangchenggang Area Male Health and Examination Survey in China?
### Response:
| Total testosterone and SHBG are independent risk factors of metabolic syndrome. Prospective studies are needed to explore whether the association between sex hormones and metabolic syndrome was mediated by insulin resistance or obesity. |
### Instruction:
Does extracorporeal shockwave therapy show site-specific effects in osteoarthritis of the knee in rats?
### Response:
| ESWT shows site-specific effects at distal femur and proximal tibia in osteoarthritis of the knee in rats. The effects of ESWT are consistent at distal femur and proximal tibia, with no additive effects when both areas were simultaneously treated. |
### Instruction:
Does platelet-rich plasma enhance autograft revascularization and reinnervation in a dog model of anterior cruciate ligament reconstruction?
### Response:
| During graft remodeling, we observed a time-dependent change in gene expression after ACL reconstruction surgery. In addition, these results demonstrate that PRP alters the expression of some target genes at certain times, particularly during the early stages of graft remodeling. Platelet-rich plasma could promote revascularization and reinnervation, which might explain the enhancing effect of PRP on ACL graft maturation. |
### Instruction:
Does n-acetylcysteine administration improve patient outcome after liver resection?
### Response:
| In spite of promising experimental evidence, this study was not able to demonstrate any advantage in the routine administration of peri-operative NAC in patients undergoing a liver resection. |
### Instruction:
Does the ultra-potent and selective TLR8 agonist VTX-294 activate human newborn and adult leukocytes?
### Response:
| VTX-294 is a novel ultra-potent TLR8 agonist that activates newborn and adult leukocytes and is a candidate vaccine adjuvant in both early life and adulthood. |
### Instruction:
Does sOX2 overexpression correlate with poor prognosis in laryngeal squamous cell carcinoma?
### Response:
| SOX2 may contribute to the malignant progression of laryngeal squamous cell carcinoma (LSCC), and present as a useful prognostic marker and a potential therapeutic target for LSCC patients. |
### Instruction:
Is low sensitivity of type VII collagen enzyme-linked immunosorbent assay in epidermolysis bullosa acquisita : serration pattern analysis on skin biopsy required for diagnosis?
### Response:
| The coll VII ELISA has limited added value in SSS-negative EBA cases. The ELISA test is valuable in differentiating EBA from antilaminin-332 mucous membrane pemphigoid and anti-p200 pemphigoid and in its ability to monitor patients with EBA serologically. U-serration pattern analysis on immunofluorescence skin biopsy is the gold standard for the diagnosis of EBA. |
### Instruction:
Does physical activity correlate with arterial stiffness in community-dwelling individuals with stroke?
### Response:
| We found that arterial stiffness is elevated in community-dwelling, ambulatory individuals with stroke relative to healthy people. Multivariable regression analysis suggests that aerobic capacity (VO2 peak) may contribute to the variance of cfPWV after accounting for the effects of age and medication use. Whether intense risk modification and augmented physical activity will improve arterial stiffness in this population remains to be determined. |
### Instruction:
Is [ The use of adrenaline for the treatment of anaphylaxis : the use by first-aid personnel recommended ]?
### Response:
| The actual management of anaphylaxis does not fit with the International Guidelines. Anaphylaxis treatment protocols according to the international criteria should be applied in ED. Risk reduction strategies cannot rely only on the self-administration of epinephrine by the patient and should put forward a better efficiency of all first-aid care providers. A targeted educational intervention should be developed to improve the care of emergency medical services providers. They should have self-injectable-epinephrine available and should be coached to use it properly. |
### Instruction:
Is neocortical β-amyloid area associated with dementia and APOE in the oldest-old?
### Response:
| Lower levels of percent area in APOE ε2 carriers may reflect lower total β-amyloid and may contribute to APOE ε2 carriers' decreased risk of dementia, despite high β-amyloid plaque scores. The relationship between β-amyloid plaques and dementia in the oldest-old may vary by APOE genotype. |
### Instruction:
Is the effect of amyloid β on cognitive decline modulated by neural integrity in cognitively normal elderly?
### Response:
| Our findings indicate that cognitive trajectories deteriorate at a faster rate in cognitively normal individuals expressing Aβ burden and neurodegeneration within specific AD-sensitive regions. |
### Instruction:
Is aspirin associated with lower melanoma risk among postmenopausal Caucasian women : the Women 's Health Initiative?
### Response:
| Postmenopausal women who used ASA had a significantly lower risk of melanoma, and longer duration of ASA use was associated with greater protection. Although this study was limited by the observational design and self-report of NSAID use, the findings suggest that ASA may have a chemopreventive effect against the development of melanoma and warrant further clinical investigation. |
### Instruction:
Does an integrative genomic and transcriptomic analysis reveal potential targets associated with cell proliferation in uterine leiomyomas?
### Response:
| The integrative genomic and transcriptomic approach indicated that FGFR1 and IGFBP5 amplification, as well as the consequent up-regulation of the protein products, plays an important role in the aetiology of ULs and thus provides data for potential drug therapies development to target genes associated with cellular proliferation in ULs. |
### Instruction:
Do dietary nucleotides extend the life span in Sprague-Dawley rats?
### Response:
| Long-term feeding of NTs could dose-dependently increase life span in Sprague-Dawley rats, especially, the tumor-bearing ones. Moreover, the antioxidative property of NTs may be responsible for the increased life span. |
### Instruction:
Do predictive equations overestimate the resting metabolic rate in postmenopausal women?
### Response:
| None of the equations to approach, in this study showed precision in the estimative of RMR, all prediction equations overestimated RMR values in Brazilians' postmenopausal women, although the MSJ predictive equation showed the greater approximation of RMRmeasured for this population. |
### Instruction:
Does dehydration protection provided by a maternal cuticle improve offspring fitness in the moss Funaria hygrometrica?
### Response:
| This study represents the strongest evidence to date that the structure of the calyptra cuticle functions in dehydration protection of the immature moss sporophyte. The investment in a maternal calyptra with a multilayered cuticle increases offspring fitness and provides a functional explanation for calyptra retention across mosses. The moss calyptra may represent the earliest occurance of maternal protection via structural provisioning of a cuticle in green plants. |
### Instruction:
Does the folate precursor para-aminobenzoic acid elicit induced resistance against Cucumber mosaic virus and Xanthomonas axonopodis?
### Response:
| The present study is the first to demonstrate the effective elicitation of SAR by a folate precursor under field conditions. |
### Instruction:
Does brief psycho-education affect circadian variability in nicotine craving during cessation?
### Response:
| Results demonstrate that brief non-pharmacological interventions can affect circadian craving patterns during smoking cessation. Further investigation of mechanisms of change and of the impact of psycho-education on cessation outcomes is warranted. |
### Instruction:
Are polymorphisms of interleukin-1 Beta and interleukin-17Alpha genes associated with restless legs syndrome?
### Response:
| This study provides preliminary evidence of a genetic association between IL1B and IL17A genes and RLS. |
### Instruction:
Does undecaprenyl pyrophosphate phosphatase confer low-level resistance to bacitracin in Enterococcus faecalis?
### Response:
| The results demonstrate that low-level bacitracin resistance in E. faecalis is mediated by a BacA-type UppP. |
### Instruction:
Is mMR vaccination of children with egg allergy safe?
### Response:
| Based on our study, we conclude that the Priorix MMR vaccine may be administered just as safely to children diagnosed with egg allergy as to other children. We found no evidence in support of the current Danish recommendations. We therefore recommend that the Statens Serum Institut, the Danish Paediatric Society and/or the Danish Health and Medicines Authority reconsider these recommendations. |
### Instruction:
Does cDK2 knockdown enhance head and neck cancer cell radiosensitivity?
### Response:
| Our findings suggest that targeting of CDK2 radiosensitizes HNSCC cells growing as monolayer. Additional studies performed under more physiological conditions are warranted to clarify the potential of CDK2 as target in radiotherapy. |
### Instruction:
Is rNA in blood altered prior to hemorrhagic transformation in ischemic stroke?
### Response:
| Identified genes correspond to differences in inflammation and coagulation that may predispose to HT in ischemic stroke. Given the adverse impact of HT on stroke outcomes, further evaluation of the identified genes and pathways is warranted to determine their potential as therapeutic targets to reduce HT and as markers of HT risk. |
### Instruction:
Is new-onset atrial fibrillation a predictor of subsequent hyperthyroidism : a nationwide cohort study?
### Response:
| New-onset AF seems to be a predictor of hyperthyroidism. Increased focus on subsequent risk of hyperthyroidism in patients with new-onset AF is warranted. |
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